{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:26:11Z","timestamp":1781382371211,"version":"3.54.1"},"reference-count":251,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["NWO-TTW P19-03"],"award-info":[{"award-number":["NWO-TTW P19-03"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The global burden of Inflammatory bowel disease (IBD) has been rising over the last decades. IBD is an intestinal disorder with a complex and largely unknown etiology. The disease is characterized by a chronically inflamed gastrointestinal tract, with intermittent phases of exacerbation and remission. This compromised intestinal barrier can contribute to, enhance, or even enable the toxicity of drugs, food-borne chemicals and particulate matter. This review discusses whether the rising prevalence of IBD in our society warrants the consideration of IBD patients as a specific population group in toxicological safety assessment. Various in vivo, ex vivo and in vitro models are discussed that can simulate hallmarks of IBD and may be used to study the effects of prevalent intestinal inflammation on the hazards of these various toxicants. In conclusion, risk assessments based on healthy individuals may not sufficiently cover IBD patient safety and it is suggested to consider this susceptible subgroup of the population in future toxicological assessments.<\/jats:p>","DOI":"10.1007\/s00204-024-03844-w","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T14:02:48Z","timestamp":1725890568000},"page":"3519-3541","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Elevated risk of adverse effects from foodborne contaminants and drugs in inflammatory bowel disease: a review"],"prefix":"10.1007","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1770-4153","authenticated-orcid":false,"given":"Tom","family":"Walraven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1471-8921","authenticated-orcid":false,"given":"Mathias","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2605-5590","authenticated-orcid":false,"given":"Jingxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-4703","authenticated-orcid":false,"given":"Joanne M.","family":"Donkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-9376","authenticated-orcid":false,"given":"Marjolijn","family":"Duijvestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evita","family":"van de Steeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-1815","authenticated-orcid":false,"given":"Nynke I.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-4272","authenticated-orcid":false,"given":"Hans","family":"Bouwmeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"issue":"11","key":"3844_CR1","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.3390\/nu12113408","volume":"12","author":"SY Ahmad","year":"2020","unstructured":"Ahmad SY, Friel J, Mackay D (2020) The effects of non-nutritive artificial sweeteners, aspartame and sucralose, on the Gut microbiome in healthy adults: secondary outcomes of a randomized double-blinded crossover clinical trial. Nutrients 12(11):3408. https:\/\/doi.org\/10.3390\/nu12113408","journal-title":"Nutrients"},{"issue":"33","key":"3844_CR2","doi-asserted-by":"publisher","first-page":"44587","DOI":"10.1007\/s11356-021-14700-0","volume":"28","author":"RH Alasfar","year":"2021","unstructured":"Alasfar RH, Isaifan RJ (2021) Aluminum environmental pollution: the silent killer. Environ Sci Pollut Res Int 28(33):44587\u201344597. https:\/\/doi.org\/10.1007\/s11356-021-14700-0","journal-title":"Environ Sci Pollut Res Int"},{"issue":"1","key":"3844_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","volume":"5","author":"S Alatab","year":"2020","unstructured":"Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, Sadeghi A, Nixon MR, Abdoli A, Abolhassani H et al (2020) The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 5(1):17\u201330. https:\/\/doi.org\/10.1016\/S2468-1253(19)30333-4","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"1","key":"3844_CR4","doi-asserted-by":"publisher","first-page":"15055","DOI":"10.1038\/s41598-021-94280-8","volume":"11","author":"A Amamou","year":"2021","unstructured":"Amamou A, Rouland M, Yaker L, Goichon A, Gu\u00e9rin C, Aziz M, Savoye G, Marion-Letellier R (2021) Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation. Sci Rep 11(1):15055. https:\/\/doi.org\/10.1038\/s41598-021-94280-8","journal-title":"Sci Rep"},{"issue":"2","key":"3844_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1039\/D1LC00669J","volume":"22","author":"HE Amirabadi","year":"2022","unstructured":"Amirabadi HE, Donkers JM, Wierenga E, Ingenhut B, Pieters L, Stevens L, Donkers T, Westerhout J, Masereeuw R, Bobeldijk-Pastorova I et al (2022) Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants. Lab Chip 22(2):326\u2013342. https:\/\/doi.org\/10.1039\/D1LC00669J","journal-title":"Lab Chip"},{"issue":"5","key":"3844_CR6","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/ibd.21455","volume":"17","author":"AN Ananthakrishnan","year":"2011","unstructured":"Ananthakrishnan AN, McGinley EL, Binion DG, Saeian K (2011) Ambient air pollution correlates with hospitalizations for inflammatory bowel disease: an ecologic analysis. Inflamm Bowel Dis 17(5):1138\u20131145. https:\/\/doi.org\/10.1002\/ibd.21455","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"3844_CR7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/ng.764","volume":"43","author":"CA Anderson","year":"2011","unstructured":"Anderson CA, Boucher G, Lees CW, Franke A, D\u2019Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A et al (2011) Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43(3):246\u2013252. https:\/\/doi.org\/10.1038\/ng.764","journal-title":"Nat Genet"},{"key":"3844_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.amsu.2016.07.019","volume":"11","author":"E Antoniou","year":"2016","unstructured":"Antoniou E, Margonis GA, Angelou A, Pikouli A, Argiri P, Karavokyros I, Papalois A, Pikoulis E (2016) The TNBS-induced colitis animal model: an overview. Ann Med Surg (lond) 11:9\u201315. https:\/\/doi.org\/10.1016\/j.amsu.2016.07.019","journal-title":"Ann Med Surg (lond)"},{"issue":"6","key":"3844_CR9","first-page":"1357","volume":"16","author":"Y Araki","year":"2006","unstructured":"Araki Y, Sugihara H, Hattori T (2006) In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis. Oncol Rep 16(6):1357\u20131362","journal-title":"Oncol Rep"},{"issue":"8","key":"3844_CR10","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2019.5809","volume":"17","author":"Authority (EFSA) EFS","year":"2019","unstructured":"Authority (EFSA) EFS (2019) Statement on the available outcomes of the human health assessment in the context of the pesticides peer review of the active substance chlorpyrifos. EFSA J 17(8):e05809. https:\/\/doi.org\/10.2903\/j.efsa.2019.5809","journal-title":"EFSA J"},{"issue":"4","key":"3844_CR11","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2023.7939","volume":"21","author":"Authority (EFSA) EFS, Carrasco Cabrera L, Di Piazza G, Dujardin B, Medina Pastor P","year":"2023","unstructured":"Authority (EFSA) EFS, Carrasco Cabrera L, Di Piazza G, Dujardin B, Medina Pastor P (2023) The 2021 European Union report on pesticide residues in food. EFSA J 21(4):e07939. https:\/\/doi.org\/10.2903\/j.efsa.2023.7939","journal-title":"EFSA J"},{"issue":"6","key":"3844_CR12","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1093\/ecco-jcc\/jjaa254","volume":"15","author":"AS Bancil","year":"2021","unstructured":"Bancil AS, Sandall AM, Rossi M, Chassaing B, Lindsay JO, Whelan K (2021) Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation: Mechanistic Insights in Inflammatory Bowel Disease. J Crohn\u2019s Colitis 15(6):1068\u20131079. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaa254","journal-title":"J Crohn\u2019s Colitis"},{"key":"3844_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113935","volume":"178","author":"P Barciela","year":"2023","unstructured":"Barciela P, Perez-Vazquez A, Prieto MA (2023) Azo dyes in the food industry: features, classification, toxicity, alternatives, and regulation. Food Chem Toxicol 178:113935. https:\/\/doi.org\/10.1016\/j.fct.2023.113935","journal-title":"Food Chem Toxicol"},{"issue":"Suppl 1","key":"3844_CR14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1159\/000341681","volume":"30","author":"C Bauer","year":"2012","unstructured":"Bauer C, Duewell P, Lehr H-A, Endres S, Schnurr M (2012) Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors. Dig Dis 30(Suppl 1):82\u201390. https:\/\/doi.org\/10.1159\/000341681","journal-title":"Dig Dis"},{"key":"3844_CR15","doi-asserted-by":"publisher","unstructured":"Benotti MJ, Trenholm RA, Vanderford BJ, Holady JC, Stanford BD, Snyder SA (2009) Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water. Environ Sci Technol 43(3):597\u2013603. https:\/\/doi.org\/10.1021\/es801845a","DOI":"10.1021\/es801845a"},{"issue":"5","key":"3844_CR16","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/j.1572-0241.2006.00381.x","volume":"101","author":"CN Bernstein","year":"2006","unstructured":"Bernstein CN, Rawsthorne P, Cheang M, Blanchard JF (2006) A population-based case control study of potential risk factors for IBD. Am J Gastroenterol 101(5):993\u20131002. https:\/\/doi.org\/10.1111\/j.1572-0241.2006.00381.x","journal-title":"Am J Gastroenterol"},{"key":"3844_CR17","doi-asserted-by":"crossref","unstructured":"Bischoff SC, Mailer R, Pabst O, Weier G, Sedlik W, Li Z, Chen JJ, Murphy DL, Gershon MD (2009) Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2, 4, 6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol-Gastroint Liver Physiol 296(3):G685\u2013G695","DOI":"10.1152\/ajpgi.90685.2008"},{"issue":"3","key":"3844_CR18","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3390\/cells11030335","volume":"11","author":"O Biskou","year":"2022","unstructured":"Biskou O, Meira de-Faria F, Walter SM, Winberg ME, Haapaniemi S, Myrelid P, S\u00f6derholm JD, Keita \u00c5V. (2022) Increased Numbers of Enteric Glial Cells in the Peyer\u2019s Patches and Enhanced Intestinal Permeability by Glial Cell Mediators in Patients with Ileal Crohn\u2019s Disease. Cells 11(3):335. https:\/\/doi.org\/10.3390\/cells11030335","journal-title":"Cells"},{"issue":"10","key":"3844_CR19","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1136\/gut.2007.134817","volume":"57","author":"A Bitton","year":"2008","unstructured":"Bitton A, Dobkin PL, Edwardes MD, Sewitch MJ, Meddings JB, Rawal S, Cohen A, Vermeire S, Dufresne L, Franchimont D, Wild GE (2008) Predicting relapse in Crohn\u2019s disease: a biopsychosocial model. Gut 57(10):1386\u20131392. https:\/\/doi.org\/10.1136\/gut.2007.134817","journal-title":"Gut"},{"key":"3844_CR20","doi-asserted-by":"publisher","first-page":"239784731772635","DOI":"10.1177\/2397847317726351","volume":"1","author":"D Bovard","year":"2017","unstructured":"Bovard D, Iskandar A, Luettich K, Hoeng J, Peitsch MC (2017) Organs-on-a-chip: a new paradigm for toxicological assessment and preclinical drug development. Toxicol Res Appl 1:2397847317726351. https:\/\/doi.org\/10.1177\/2397847317726351","journal-title":"Toxicol Res Appl"},{"issue":"8","key":"3844_CR21","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1136\/gut.2008.163667","volume":"58","author":"S Brand","year":"2009","unstructured":"Brand S (2009) Crohn\u2019s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn\u2019s disease. Gut 58(8):1152\u20131167. https:\/\/doi.org\/10.1136\/gut.2008.163667","journal-title":"Gut"},{"key":"3844_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.107732","volume":"172","author":"G Bredeck","year":"2023","unstructured":"Bredeck G, Busch M, Rossi A, Stahlmecke B, Fomba KW, Herrmann H, Schins RPF (2023) Inhalable Saharan dust induces oxidative stress, NLRP3 inflammasome activation, and inflammatory cytokine release. Environ Int 172:107732. https:\/\/doi.org\/10.1016\/j.envint.2023.107732","journal-title":"Environ Int"},{"key":"3844_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110536","volume":"193","author":"M Busch","year":"2021","unstructured":"Busch M, Bredeck G, K\u00e4mpfer AAM, Schins RPF (2021) Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine. Environ Res 193:110536. https:\/\/doi.org\/10.1016\/j.envres.2020.110536","journal-title":"Environ Res"},{"issue":"8","key":"3844_CR24","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/biom12081095","volume":"12","author":"M Busch","year":"2022","unstructured":"Busch M, Bredeck G, Waag F, Rahimi K, Ramachandran H, Bessel T, Barcikowski S, Herrmann A, Rossi A, Schins RPF (2022a) Assessing the NLRP3 inflammasome activating potential of a large panel of micro- and nanoplastics in THP-1 cells. Biomolecules 12(8):1095. https:\/\/doi.org\/10.3390\/biom12081095","journal-title":"Biomolecules"},{"key":"3844_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.898039","author":"M Busch","year":"2022","unstructured":"Busch M, Ramachandran H, Wahle T, Rossi A, Schins RPF (2022b) Investigating the role of the NLRP3 inflammasome pathway in acute intestinal inflammation: use of THP-1 knockout cell lines in an advanced triple culture model. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2022.898039","journal-title":"Front Immunol"},{"key":"3844_CR26","doi-asserted-by":"publisher","unstructured":"Busch M, Brouwer H, Aalderink G, Bredeck G, K\u00e4mpfer AAM, Schins RPF, Bouwmeester H (2023) Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models. Front Toxicol [Internet]. [accessed 2024 Mar 13] 5. https:\/\/doi.org\/10.3389\/ftox.2023.1112212","DOI":"10.3389\/ftox.2023.1112212"},{"issue":"1","key":"3844_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053647","volume":"8","author":"PM Cano","year":"2013","unstructured":"Cano PM, Seeboth J, Meurens F, Cognie J, Abrami R, Oswald IP, Guzylack-Piriou L (2013) Deoxynivalenol as a new factor in the persistence of intestinal inflammatory diseases: an emerging hypothesis through possible modulation of Th17-mediated Response. PLoS ONE 8(1):e53647. https:\/\/doi.org\/10.1371\/journal.pone.0053647","journal-title":"PLoS ONE"},{"issue":"6","key":"3844_CR28","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1093\/femsre\/fux048","volume":"41","author":"R Chandrasekaran","year":"2017","unstructured":"Chandrasekaran R, Lacy DB (2017) The role of toxins in Clostridium difficile infection. FEMS Microbiol Rev 41(6):723\u2013750","journal-title":"FEMS Microbiol Rev"},{"issue":"7541","key":"3844_CR29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature14232","volume":"519","author":"B Chassaing","year":"2015","unstructured":"Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT (2015) Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519(7541):92\u201396. https:\/\/doi.org\/10.1038\/nature14232","journal-title":"Nature"},{"key":"3844_CR30","doi-asserted-by":"publisher","unstructured":"Chassaing B, Aitken JD, Malleshappa M, Vijay-Kumar M (2014) Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol. 104:Unit-15.25. https:\/\/doi.org\/10.1002\/0471142735.im1525s104","DOI":"10.1002\/0471142735.im1525s104"},{"issue":"1","key":"3844_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.stem.2013.12.005","volume":"14","author":"KG Chen","year":"2014","unstructured":"Chen KG, Mallon BS, McKay RDG, Robey PG (2014) Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell 14(1):13\u201326. https:\/\/doi.org\/10.1016\/j.stem.2013.12.005","journal-title":"Cell Stem Cell"},{"key":"3844_CR32","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.impact.2017.07.005","volume":"8","author":"H Chen","year":"2017","unstructured":"Chen H, Zhao R, Wang B, Cai C, Zheng L, Wang H, Wang M, Ouyang H, Zhou X, Chai Z et al (2017) The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice. NanoImpact 8:80\u201388. https:\/\/doi.org\/10.1016\/j.impact.2017.07.005","journal-title":"NanoImpact"},{"key":"3844_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118464","volume":"249","author":"D Chen","year":"2024","unstructured":"Chen D, Parks CG, Hofmann JN, Beane Freeman LE, Sandler DP (2024) Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study. Environ Res 249:118464. https:\/\/doi.org\/10.1016\/j.envres.2024.118464","journal-title":"Environ Res"},{"key":"3844_CR34","doi-asserted-by":"publisher","unstructured":"Chen X, Wang S, Mao X, Xiang X, Ye S, Chen J, Zhu A, Meng Y, Yang X, Peng S et al. (2023) Adverse health effects of emerging contaminants on inflammatory bowel disease. Front Public Health. https:\/\/doi.org\/10.3389\/fpubh.2023.1140786","DOI":"10.3389\/fpubh.2023.1140786"},{"issue":"18","key":"3844_CR35","doi-asserted-by":"publisher","first-page":"4126","DOI":"10.1039\/D3LC00615H","volume":"23","author":"AE Cherwin","year":"2023","unstructured":"Cherwin AE, Templeton HN, Ehrlich AT, Patlin BH, Henry CS, Tobet SA (2023) Microfluidic organotypic device to test intestinal mucosal barrier permeability ex vivo. Lab Chip 23(18):4126\u20134133. https:\/\/doi.org\/10.1039\/D3LC00615H","journal-title":"Lab Chip"},{"issue":"8","key":"3844_CR36","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1039\/C9MT00144A","volume":"11","author":"GM Chiocchetti","year":"2019","unstructured":"Chiocchetti GM, V\u00e9lez D, Devesa V (2019) Inorganic arsenic causes intestinal barrier disruption. Metallomics 11(8):1411\u20131418. https:\/\/doi.org\/10.1039\/C9MT00144A","journal-title":"Metallomics"},{"issue":"2","key":"3844_CR37","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1096\/fj.201902396R","volume":"34","author":"E-K Choi","year":"2020","unstructured":"Choi E-K, Aring L, Das NK, Solanki S, Inohara N, Iwase S, Samuelson LC, Shah YM, Seo YA (2020) Impact of dietary manganese on experimental colitis in mice. FASEB J 34(2):2929\u20132943. https:\/\/doi.org\/10.1096\/fj.201902396R","journal-title":"FASEB J"},{"issue":"3","key":"3844_CR38","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/s12276-021-00571-5","volume":"53","author":"T-Y Choi","year":"2021","unstructured":"Choi T-Y, Choi T-I, Lee Y-R, Choe S-K, Kim C-H (2021) Zebrafish as an animal model for biomedical research. Exp Mol Med 53(3):310\u2013317. https:\/\/doi.org\/10.1038\/s12276-021-00571-5","journal-title":"Exp Mol Med"},{"issue":"7","key":"3844_CR39","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1053\/j.gastro.2004.03.013","volume":"126","author":"MD Coates","year":"2004","unstructured":"Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM (2004) Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126(7):1657\u20131664","journal-title":"Gastroenterology"},{"issue":"6","key":"3844_CR40","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/apt.14226","volume":"46","author":"M Coates","year":"2017","unstructured":"Coates M, Tekin I, Vrana K, Mawe G (2017) the many potential roles of intestinal serotonin (5-hydroxytryptamine, 5-HT) signalling in inflammatory bowel disease. Aliment Pharmacol Ther 46(6):569\u2013580","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"3844_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jcmgh.2017.02.010","volume":"4","author":"F Cominelli","year":"2017","unstructured":"Cominelli F, Arseneau KO, Rodriguez-Palacios A, Pizarro TT (2017) Uncovering pathogenic mechanisms of inflammatory bowel disease using mouse models of Crohn\u2019s disease-like ileitis: what is the right model? Cell Mol Gastroenterol Hepatol 4(1):19\u201332. https:\/\/doi.org\/10.1016\/j.jcmgh.2017.02.010","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3844_CR42","doi-asserted-by":"publisher","unstructured":"Coward S, Benchimol EI, Bernstein CN, Avina-Zubieta A, Bitton A, Carroll MW, Cui Y, Hoentjen F, Hracs L, Jacobson K et al (2022) Forecasting the Incidence and Prevalence of Inflammatory Bowel Disease: A Canadian nationwide analysis. Off J Am Coll Gastroenterol ACG. https:\/\/doi.org\/10.14309\/ajg.0000000000002687","DOI":"10.14309\/ajg.0000000000002687"},{"key":"3844_CR43","doi-asserted-by":"publisher","unstructured":"d\u2019Aldebert E, Quaranta M, S\u00e9bert M, Bonnet D, Kirzin S, Portier G, Duffas J-P, Chabot S, Lluel P, Allart S et al (2020) Characterization of human colon organoids from inflammatory bowel disease patients. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2020.00363","DOI":"10.3389\/fcell.2020.00363"},{"issue":"1","key":"3844_CR44","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12992-022-00820-w","volume":"18","author":"GG da Costa","year":"2022","unstructured":"da Costa GG, da Concei\u00e7\u00e3o NG, da Silva PA, Sim\u00f5es BFT (2022) Worldwide dietary patterns and their association with socioeconomic data: an ecological exploratory study. Glob Health 18(1):31. https:\/\/doi.org\/10.1186\/s12992-022-00820-w","journal-title":"Glob Health"},{"issue":"6","key":"3844_CR45","doi-asserted-by":"publisher","DOI":"10.1063\/1.4964813","volume":"10","author":"A Dawson","year":"2016","unstructured":"Dawson A, Dyer C, Macfie J, Davies J, Karsai L, Greenman J, Jacobsen M (2016) A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow. Biomicrofluidics 10(6):064101. https:\/\/doi.org\/10.1063\/1.4964813","journal-title":"Biomicrofluidics"},{"issue":"2","key":"3844_CR46","doi-asserted-by":"publisher","first-page":"355","DOI":"10.4315\/JFP-21-184","volume":"85","author":"MJ de Oliveira","year":"2022","unstructured":"de Oliveira MJ, Galea R, Nag R, Cummins E, Gatt R, Valdramidis V (2022) Nanoparticle food applications and their toxicity: current trends and needs in risk assessment strategies. J Food Prot 85(2):355\u2013372. https:\/\/doi.org\/10.4315\/JFP-21-184","journal-title":"J Food Prot"},{"issue":"3","key":"3844_CR47","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3109\/17435390.2010.519836","volume":"5","author":"S Dekkers","year":"2011","unstructured":"Dekkers S, Krystek P, Peters RJB, Lankveld DPK, Bokkers BGH, van Hoeven-Arentzen PH, Bouwmeester H, Oomen AG (2011) Presence and risks of nanosilica in food products. Nanotoxicology 5(3):393\u2013405. https:\/\/doi.org\/10.3109\/17435390.2010.519836","journal-title":"Nanotoxicology"},{"issue":"10","key":"3844_CR48","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1177\/1535370218782139","volume":"243","author":"JA DeLuca","year":"2018","unstructured":"DeLuca JA, Allred KF, Menon R, Riordan R, Weeks BR, Jayaraman A, Allred CD (2018) Bisphenol-A alters microbiota metabolites derived from aromatic amino acids and worsens disease activity during colitis. Exp Biol Med (maywood) 243(10):864\u2013875. https:\/\/doi.org\/10.1177\/1535370218782139","journal-title":"Exp Biol Med (maywood)"},{"key":"3844_CR49","first-page":"99","volume":"223","author":"LA Dieleman","year":"1997","unstructured":"Dieleman LA, Pe\u00f1a AS, Meuwissen SG, van RE. (1997) Role of animal models for the pathogenesis and treatment of inflammatory bowel disease. Scand J Gastroenterol Suppl 223:99\u2013104","journal-title":"Scand J Gastroenterol Suppl"},{"key":"3844_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.158017","volume":"850","author":"M Djouina","year":"2022","unstructured":"Djouina M, Waxin C, Lepr\u00eatre F, Tardivel M, Tillement O, Vasseur F, Figeac M, Bongiovanni A, Sebda S, Desreumaux P et al (2022) Gene\/environment interaction in the susceptibility of Crohn\u2019s disease patients to aluminum. Sci Total Environ 850:158017. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.158017","journal-title":"Sci Total Environ"},{"key":"3844_CR51","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.cotox.2020.11.002","volume":"25","author":"JM Donkers","year":"2021","unstructured":"Donkers JM, Eslami Amirabadi H, van de Steeg E (2021) Intestine-on-a-chip: next level in vitro research model of the human intestine. Curr Opin Toxicol 25:6\u201314. https:\/\/doi.org\/10.1016\/j.cotox.2020.11.002","journal-title":"Curr Opin Toxicol"},{"key":"3844_CR52","doi-asserted-by":"publisher","unstructured":"Donkers JM, Steeg E van de, Wiese M (2024) A host-microbial metabolite interaction gut-on-a-chip model of the adult human intestine demonstrates beneficial effects upon inulin treatment of gut microbiome. Microb Res Rep 3(2):null-null. https:\/\/doi.org\/10.20517\/mrr.2023.79","DOI":"10.20517\/mrr.2023.79"},{"issue":"1","key":"3844_CR53","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1038\/s41598-019-38524-8","volume":"9","author":"RH Dosh","year":"2019","unstructured":"Dosh RH, Jordan-Mahy N, Sammon C, Le Maitre CL (2019) Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease. Sci Rep 9(1):1812. https:\/\/doi.org\/10.1038\/s41598-019-38524-8","journal-title":"Sci Rep"},{"issue":"10","key":"3844_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276195","volume":"17","author":"I Dotti","year":"2022","unstructured":"Dotti I, Mayorgas A, Salas A (2022) Generation of human colon organoids from healthy and inflammatory bowel disease mucosa. PLoS ONE 17(10):e0276195. https:\/\/doi.org\/10.1371\/journal.pone.0276195","journal-title":"PLoS ONE"},{"issue":"5804","key":"3844_CR55","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1126\/science.1135245","volume":"314","author":"RH Duerr","year":"2006","unstructured":"Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A et al (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314(5804):1461\u20131463. https:\/\/doi.org\/10.1126\/science.1135245","journal-title":"Science"},{"issue":"11","key":"3844_CR56","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1128\/iai.61.11.4569-4574.1993","volume":"61","author":"L Eckmann","year":"1993","unstructured":"Eckmann L, Kagnoff MF, Fierer J (1993) Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immun 61(11):4569\u20134574. https:\/\/doi.org\/10.1128\/iai.61.11.4569-4574.1993","journal-title":"Infect Immun"},{"issue":"9","key":"3844_CR57","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2016.4545","volume":"14","author":"EFSA","year":"2016","unstructured":"EFSA (2016) Re-evaluation of titanium dioxide (E 171) as a food additive. EFSA J 14(9):e04545. https:\/\/doi.org\/10.2903\/j.efsa.2016.4545","journal-title":"EFSA J"},{"issue":"4","key":"3844_CR58","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2023.6857","volume":"21","author":"Enzymes and Processing Aids (CEP),","year":"2023","unstructured":"EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Lambr\u00e9 C, Barat Baviera JM, Bolognesi C, Chesson A, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, et al (2023) Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs. EFSA J 21(4):e06857. https:\/\/doi.org\/10.2903\/j.efsa.2023.6857","journal-title":"EFSA J"},{"issue":"5","key":"3844_CR59","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2021.6585","volume":"19","author":"EFSA, Younes M, Aquilina G, Castle","year":"2021","unstructured":"EFSA, Younes M, Aquilina G, Castle L, Engel K-H, Fowler P, Frutos Fernandez MJ, F\u00fcrst P, Gundert-Remy U, G\u00fcrtler R, et al (2021) Safety assessment of titanium dioxide (E171) as a food additive. EFSA J 19(5):e06585. https:\/\/doi.org\/10.2903\/j.efsa.2021.6585","journal-title":"EFSA J"},{"issue":"2","key":"3844_CR60","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.xphs.2018.09.024","volume":"108","author":"P Erdmann","year":"2019","unstructured":"Erdmann P, Bruckmueller H, Martin P, Busch D, Haenisch S, M\u00fcller J, Wiechowska-Kozlowska A, Partecke LI, Heidecke C-D, Cascorbi I (2019) Dysregulation of mucosal membrane transporters and drug-metabolizing enzymes in ulcerative colitis. J Pharm Sci 108(2):1035\u20131046","journal-title":"J Pharm Sci"},{"issue":"4","key":"3844_CR61","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00335-021-09863-7","volume":"32","author":"AC Ericsson","year":"2021","unstructured":"Ericsson AC, Franklin CL (2021) The gut microbiome of laboratory mice: considerations and best practices for translational research. Mamm Genome 32(4):239\u2013250. https:\/\/doi.org\/10.1007\/s00335-021-09863-7","journal-title":"Mamm Genome"},{"issue":"5","key":"3844_CR62","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1093\/ibd\/izab292","volume":"28","author":"HQ Estrada","year":"2022","unstructured":"Estrada HQ, Patel S, Rabizadeh S, Casero D, Targan SR, Barrett RJ (2022) Development of a personalized intestinal fibrosis model using human intestinal organoids derived from induced pluripotent stem cells. Inflamm Bowel Dis 28(5):667\u2013679. https:\/\/doi.org\/10.1093\/ibd\/izab292","journal-title":"Inflamm Bowel Dis"},{"issue":"10","key":"3844_CR63","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.addr.2012.09.042","volume":"65","author":"M Estudante","year":"2013","unstructured":"Estudante M, Morais JG, Soveral G, Benet LZ (2013) Intestinal drug transporters: an overview. Adv Drug Deliv Rev 65(10):1340\u20131356","journal-title":"Adv Drug Deliv Rev"},{"issue":"8","key":"3844_CR64","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1111\/j.1572-0241.2000.02262.x","volume":"95","author":"JB Felder","year":"2000","unstructured":"Felder JB, Korelitz BI, Rajapakse R, Schwarz S, Horatagis AP, Gleim G (2000) Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study. Am J Gastroenterol 95(8):1949\u20131954","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"3844_CR65","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1128\/jcm.00432-15","volume":"53","author":"WG Flight","year":"2015","unstructured":"Flight WG, Smith A, Paisey C, Marchesi JR, Bull MJ, Norville PJ, Mutton KJ, Webb AK, Bright-Thomas RJ, Jones AM, Mahenthiralingam E (2015) Rapid detection of emerging pathogens and loss of microbial diversity associated with severe lung disease in cystic fibrosis. J Clin Microbiol 53(7):2022\u20132029. https:\/\/doi.org\/10.1128\/jcm.00432-15","journal-title":"J Clin Microbiol"},{"key":"3844_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123006","volume":"400","author":"SY Foong","year":"2020","unstructured":"Foong SY, Ma NL, Lam SS, Peng W, Low F, Lee BHK, Alstrup AKO, Sonne C (2020) A recent global review of hazardous chlorpyrifos pesticide in fruit and vegetables: prevalence, remediation and actions needed. J Hazard Mater 400:123006. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.123006","journal-title":"J Hazard Mater"},{"issue":"10","key":"3844_CR67","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1111\/j.1365-2036.2004.02270.x","volume":"20","author":"K Forrest","year":"2004","unstructured":"Forrest K, Symmons D, Foster P (2004) Systematic review: is ingestion of paracetamol or non-steroidal anti-inflammatory drugs associated with exacerbations of inflammatory bowel disease? Aliment Pharmacol Ther 20(10):1035\u20131043","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"3844_CR68","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.4049\/jimmunol.166.4.2793","volume":"166","author":"MM Fort","year":"2001","unstructured":"Fort MM, Lesley R, Davidson NJ, Menon S, Brombacher F, Leach MW, Rennick DM (2001) IL-4 exacerbates disease in a Th1 cell transfer model of colitis1. J Immunol 166(4):2793\u20132800. https:\/\/doi.org\/10.4049\/jimmunol.166.4.2793","journal-title":"J Immunol"},{"issue":"1","key":"3844_CR69","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2350\/08-06-0479.1","volume":"13","author":"AE Furr","year":"2010","unstructured":"Furr AE, Ranganathan S, Finn OJ (2010) Aberrant expression of MUC1 mucin in pediatric inflammatory bowel disease. Pediatr Dev Pathol 13(1):24\u201331. https:\/\/doi.org\/10.2350\/08-06-0479.1","journal-title":"Pediatr Dev Pathol"},{"issue":"9","key":"3844_CR70","doi-asserted-by":"publisher","first-page":"4144","DOI":"10.1021\/acs.jafc.3c00252","volume":"71","author":"F Gan","year":"2023","unstructured":"Gan F, Lin Z, Tang J, Chen X, Huang K (2023) Deoxynivalenol at no-observed adverse-effect levels aggravates DSS-induced colitis through the JAK2\/STAT3 signaling pathway in mice. J Agric Food Chem 71(9):4144\u20134152. https:\/\/doi.org\/10.1021\/acs.jafc.3c00252","journal-title":"J Agric Food Chem"},{"issue":"4","key":"3844_CR71","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.3892\/ijmm.2016.2728","volume":"38","author":"S Gangemi","year":"2016","unstructured":"Gangemi S, Gofita E, Costa C, Teodoro M, Briguglio G, Nikitovic D, Tzanakakis G, Tsatsakis AM, Wilks MF, Spandidos DA, Fenga C (2016) Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review). Int J Mol Med 38(4):1012\u20131020. https:\/\/doi.org\/10.3892\/ijmm.2016.2728","journal-title":"Int J Mol Med"},{"issue":"8","key":"3844_CR72","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/1751-2980.12644","volume":"19","author":"T Geiss","year":"2018","unstructured":"Geiss T, Schaefert RM, Berens S, Hoffmann P, Gauss A (2018) Risk of depression in patients with inflammatory bowel disease. J Dig Dis 19(8):456\u2013467","journal-title":"J Dig Dis"},{"issue":"6","key":"3844_CR73","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1177\/2472630320924999","volume":"25","author":"L Gijzen","year":"2020","unstructured":"Gijzen L, Marescotti D, Raineri E, Nicolas A, Lanz HL, Guerrera D, van Vught R, Joore J, Vulto P, Peitsch MC et al (2020) An intestine-on-a-chip model of plug-and-play modularity to study inflammatory processes. SLAS Technol: Transl Life Sci Innovat 25(6):585\u2013597. https:\/\/doi.org\/10.1177\/2472630320924999","journal-title":"SLAS Technol: Transl Life Sci Innovat"},{"key":"3844_CR74","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6951091","volume":"2016","author":"D Gong","year":"2016","unstructured":"Gong D, Gong X, Wang L, Yu X, Dong Q (2016) Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease. Gastroenterology Research and Practice 2016:e6951091. https:\/\/doi.org\/10.1155\/2016\/6951091","journal-title":"Gastroenterology Research and Practice"},{"issue":"4","key":"3844_CR75","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1128\/AAC.12.4.540","volume":"12","author":"GL Goodhart","year":"1977","unstructured":"Goodhart GL (1977) Effect of aminoglycosides on the chemotactic response of human polymorphonuclear leukocytes. Antimicrob Agents Chemother 12(4):540\u2013542. https:\/\/doi.org\/10.1128\/AAC.12.4.540","journal-title":"Antimicrob Agents Chemother"},{"key":"3844_CR76","doi-asserted-by":"publisher","unstructured":"Grouls M, Janssen AWF, Duivenvoorde LPM, Hooiveld GJEJ, Bouwmeester H, van der Zande M (2022) Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate. Sci Rep 12(1). https:\/\/doi.org\/10.1038\/s41598-022-17296-8","DOI":"10.1038\/s41598-022-17296-8"},{"issue":"3","key":"3844_CR77","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41385-019-0252-3","volume":"13","author":"DC Gunasekera","year":"2020","unstructured":"Gunasekera DC, Ma J, Vacharathit V, Shah P, Ramakrishnan A, Uprety P, Shen Z, Sheh A, Brayton CF, Whary MT et al (2020) The development of colitis in Il10\u2212\/\u2212 mice is dependent on IL-22. Mucosal Immunol 13(3):493\u2013506. https:\/\/doi.org\/10.1038\/s41385-019-0252-3","journal-title":"Mucosal Immunol"},{"issue":"19","key":"3844_CR78","doi-asserted-by":"publisher","first-page":"9380","DOI":"10.1039\/D1FO01351C","volume":"12","author":"M Guo","year":"2021","unstructured":"Guo M, Liu X, Tan Y, Kang F, Zhu X, Fan X, Wang C, Wang R, Liu Y, Qin X et al (2021) Sucralose enhances the susceptibility to dextran sulfate sodium (DSS) induced colitis in mice with changes in gut microbiota. Food Funct 12(19):9380\u20139390. https:\/\/doi.org\/10.1039\/D1FO01351C","journal-title":"Food Funct"},{"issue":"4","key":"3844_CR79","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/gutjnl-2023-330971","volume":"73","author":"A Guo","year":"2024","unstructured":"Guo A, Ludvigsson J, Brants\u00e6ter AL, Klingberg S, \u00d6stensson M, St\u00f8rdal K, M\u00e5rild K (2024) Early-life diet and risk of inflammatory bowel disease: a pooled study in two Scandinavian birth cohorts. Gut 73(4):590\u2013600. https:\/\/doi.org\/10.1136\/gutjnl-2023-330971","journal-title":"Gut"},{"issue":"3","key":"3844_CR80","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/gut.49.3.443","volume":"49","author":"F Halter","year":"2001","unstructured":"Halter F, Tarnawski A, Schmassmann A, Peskar B (2001) Cyclooxygenase 2\u2014implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 49(3):443\u2013453","journal-title":"Gut"},{"issue":"2","key":"3844_CR81","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ng1954","volume":"39","author":"J Hampe","year":"2007","unstructured":"Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J et al (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39(2):207\u2013211. https:\/\/doi.org\/10.1038\/ng1954","journal-title":"Nat Genet"},{"key":"3844_CR82","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3389\/fimmu.2017.00501","volume":"8","author":"L Hanyang","year":"2017","unstructured":"Hanyang L, Xuanzhe L, Xuyang C, Yujia Q, Jiarong F, Jun S, Zhihua R (2017) Application of zebrafish models in inflammatory bowel disease. Front Immunol 8:501. https:\/\/doi.org\/10.3389\/fimmu.2017.00501","journal-title":"Front Immunol"},{"issue":"7","key":"3844_CR83","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/j.1365-2982.2010.01479.x","volume":"22","author":"S Haub","year":"2010","unstructured":"Haub S, Ritze Y, Bergheim I, Pabst O, Gershon M, Bischoff S (2010) Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter. Neurogastroenterol Motil 22(7):826-e229","journal-title":"Neurogastroenterol Motil"},{"issue":"7","key":"3844_CR84","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.cmet.2021.04.015","volume":"33","author":"Z He","year":"2021","unstructured":"He Z, Chen L, Catalan-Dibene J, Bongers G, Faith JJ, Suebsuwong C, DeVita RJ, Shen Z, Fox JG, Lafaille JJ et al (2021) Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23. Cell Metab 33(7):1358-1371.e5. https:\/\/doi.org\/10.1016\/j.cmet.2021.04.015","journal-title":"Cell Metab"},{"issue":"6","key":"3844_CR85","doi-asserted-by":"publisher","first-page":"G693","DOI":"10.1152\/ajpgi.00043.2021","volume":"321","author":"V Hentschel","year":"2021","unstructured":"Hentschel V, Seufferlein T, Armacki M (2021) Intestinal organoids in coculture: redefining the boundaries of gut mucosa ex vivo modeling. Am J Physiol-Gastroint Liver Physiol 321(6):G693\u2013G704. https:\/\/doi.org\/10.1152\/ajpgi.00043.2021","journal-title":"Am J Physiol-Gastroint Liver Physiol"},{"issue":"1","key":"3844_CR86","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12989-020-00387-7","volume":"17","author":"N Hirt","year":"2020","unstructured":"Hirt N, Body-Malapel M (2020) Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature. Part Fibre Toxicol 17(1):57. https:\/\/doi.org\/10.1186\/s12989-020-00387-7","journal-title":"Part Fibre Toxicol"},{"issue":"10","key":"3844_CR87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257824","volume":"16","author":"P Hoffmann","year":"2021","unstructured":"Hoffmann P, Burmester M, Langeheine M, Brehm R, Empl MT, Seeger B, Breves G (2021) Caco-2\/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells. PLoS ONE 16(10):e0257824. https:\/\/doi.org\/10.1371\/journal.pone.0257824","journal-title":"PLoS ONE"},{"issue":"13","key":"3844_CR88","doi-asserted-by":"publisher","first-page":"4723","DOI":"10.3390\/ijerph17134723","volume":"17","author":"S Hongsibsong","year":"2020","unstructured":"Hongsibsong S, Prapamontol T, Xu T, Hammock BD, Wang H, Chen Z-J, Xu Z-L (2020) Monitoring of the organophosphate pesticide chlorpyrifos in vegetable samples from local markets in Northern Thailand by developed immunoassay. Int J Environ Res Public Health 17(13):4723. https:\/\/doi.org\/10.3390\/ijerph17134723","journal-title":"Int J Environ Res Public Health"},{"key":"3844_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110596","volume":"131","author":"H-M Huang","year":"2019","unstructured":"Huang H-M, Pai M-H, Liu J-J, Yeh S-L, Hou Y-C (2019) Effects of dietary exposure to chlorpyrifos on immune cell populations and inflammatory responses in mice with dextran sulfate sodium-induced colitis. Food Chem Toxicol 131:110596. https:\/\/doi.org\/10.1016\/j.fct.2019.110596","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"3844_CR90","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00204-019-02615-2","volume":"94","author":"H-M Huang","year":"2020","unstructured":"Huang H-M, Pai M-H, Yeh S-L, Hou Y-C (2020) Dietary exposure to chlorpyrifos inhibits the polarization of regulatory T cells in C57BL\/6 mice with dextran sulfate sodium-induced colitis. Arch Toxicol 94(1):141\u2013150. https:\/\/doi.org\/10.1007\/s00204-019-02615-2","journal-title":"Arch Toxicol"},{"issue":"4","key":"3844_CR91","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1128\/mmbr.00017-13","volume":"77","author":"JJ Hunt","year":"2013","unstructured":"Hunt JJ, Ballard JD (2013) Variations in virulence and molecular biology among emerging strains of clostridium difficile. Microbiol Mol Biol Rev 77(4):567\u2013581. https:\/\/doi.org\/10.1128\/mmbr.00017-13","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"3844_CR92","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1136\/gut.2010.219683","volume":"60","author":"A Hviid","year":"2011","unstructured":"Hviid A, Svanstr\u00f6m H, Frisch M (2011) Antibiotic use and inflammatory bowel diseases in childhood. Gut 60(1):49\u201354","journal-title":"Gut"},{"issue":"8","key":"3844_CR93","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41576-022-00466-9","volume":"23","author":"DE Ingber","year":"2022","unstructured":"Ingber DE (2022) Human organs-on-chips for disease modelling, drug development and personalized medicine. Nat Rev Genet 23(8):467\u2013491. https:\/\/doi.org\/10.1038\/s41576-022-00466-9","journal-title":"Nat Rev Genet"},{"key":"3844_CR94","doi-asserted-by":"publisher","unstructured":"Jacobse J, Li J, Rings EHHM, Samsom JN, Goettel JA (2021) Intestinal regulatory t cells as specialized tissue-restricted immune cells in intestinal immune homeostasis and disease. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2021.716499","DOI":"10.3389\/fimmu.2021.716499"},{"issue":"9","key":"3844_CR95","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1124\/dmd.114.058065","volume":"42","author":"J Jahnel","year":"2014","unstructured":"Jahnel J, Fickert P, Hauer AC, H\u00f6genauer C, Avian A, Trauner M (2014) Inflammatory bowel disease alters intestinal bile acid transporter expression. Drug Metab Dispos 42(9):1423\u20131431","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"3844_CR96","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1093\/ibd\/izac212","volume":"29","author":"SA Jelinsky","year":"2023","unstructured":"Jelinsky SA, Derksen M, Bauman E, Verissimo CS, van Dooremalen WTM, Roos JL, Higuera Bar\u00f3n C, Caballero-Franco C, Johnson BG, Rooks MG et al (2023) Molecular and functional characterization of human intestinal organoids and monolayers for modeling epithelial barrier. Inflamm Bowel Dis 29(2):195\u2013206. https:\/\/doi.org\/10.1093\/ibd\/izac212","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"3844_CR97","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.cgh.2012.01.010","volume":"10","author":"T Jess","year":"2012","unstructured":"Jess T, Rungoe C, Peyrin-Biroulet L (2012) Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies. Clin Gastroenterol Hepatol 10(6):639\u2013645. https:\/\/doi.org\/10.1016\/j.cgh.2012.01.010","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"3844_CR98","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","volume":"63","author":"MEV Johansson","year":"2014","unstructured":"Johansson MEV, Gustafsson JK, Holm\u00e9n-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sj\u00f6vall H, Hansson GC (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63(2):281\u2013291. https:\/\/doi.org\/10.1136\/gutjnl-2012-303207","journal-title":"Gut"},{"issue":"4","key":"3844_CR99","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0091-3057(01)00745-6","volume":"71","author":"BJ Jones","year":"2002","unstructured":"Jones BJ, Blackburn TP (2002) The medical benefit of 5-HT research. Pharmacol Biochem Behav 71(4):555\u2013568","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"3844_CR100","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/gut.2010.223263","volume":"60","author":"M Joossens","year":"2011","unstructured":"Joossens M, Huys G, Cnockaert M, De Preter V, Verbeke K, Rutgeerts P, Vandamme P, Vermeire S (2011) Dysbiosis of the faecal microbiota in patients with Crohn\u2019s disease and their unaffected relatives. Gut 60(5):631\u2013637. https:\/\/doi.org\/10.1136\/gut.2010.223263","journal-title":"Gut"},{"issue":"3","key":"3844_CR101","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s44164-022-00017-w","volume":"1","author":"A Joshi","year":"2022","unstructured":"Joshi A, Soni A, Acharya S (2022) In vitro models and ex vivo systems used in inflammatory bowel disease. In Vitro Models 1(3):213\u2013227. https:\/\/doi.org\/10.1007\/s44164-022-00017-w","journal-title":"In Vitro Models"},{"issue":"7422","key":"3844_CR102","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Philip Schumm L, Sharma Y, Anderson CA et al (2012) Host\u2013microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491(7422):119\u2013124. https:\/\/doi.org\/10.1038\/nature11582","journal-title":"Nature"},{"key":"3844_CR103","unstructured":"Jr CAJ, Travers P, Walport M, Shlomchik MJ Jr, Travers P, Walport M, Shlomchik MJ (2001) Immunobiology, 5th edn. Garland Science, New York"},{"key":"3844_CR104","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.tiv.2017.08.011","volume":"45","author":"AAM K\u00e4mpfer","year":"2017","unstructured":"K\u00e4mpfer AAM, Urb\u00e1n P, Gioria S, Kanase N, Stone V, Kinsner-Ovaskainen A (2017) Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state. Toxicol in Vitro 45:31\u201343. https:\/\/doi.org\/10.1016\/j.tiv.2017.08.011","journal-title":"Toxicol in Vitro"},{"key":"3844_CR105","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.104738","volume":"63","author":"AAM K\u00e4mpfer","year":"2020","unstructured":"K\u00e4mpfer AAM, Urb\u00e1n P, La Spina R, Jim\u00e9nez IO, Kanase N, Stone V, Kinsner-Ovaskainen A (2020) Ongoing inflammation enhances the toxicity of engineered nanomaterials: application of an in vitro co-culture model of the healthy and inflamed intestine. Toxicol in Vitro 63:104738. https:\/\/doi.org\/10.1016\/j.tiv.2019.104738","journal-title":"Toxicol in Vitro"},{"key":"3844_CR106","doi-asserted-by":"publisher","DOI":"10.1007\/s44164-022-00025-w","author":"AAM K\u00e4mpfer","year":"2022","unstructured":"K\u00e4mpfer AAM, Shah U-K, Chu SL, Busch M, B\u00fcttner V, He R, Rothen-Rutishauser B, Schins RPF, Jenkins GJ (2022) Interlaboratory comparison of an intestinal triple culture to confirm transferability and reproducibility. In Vitro Models. https:\/\/doi.org\/10.1007\/s44164-022-00025-w","journal-title":"In Vitro Models"},{"key":"3844_CR107","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21201-7","author":"M Kasendra","year":"2018","unstructured":"Kasendra M, Tovaglieri A, Sontheimer-Phelps A, Jalili-Firoozinezhad S, Bein A, Chalkiadaki A, Scholl W, Zhang C, Rickner H, Richmond CA et al (2018) Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-018-21201-7","journal-title":"Sci Rep"},{"issue":"7","key":"3844_CR108","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1093\/ibd\/izz328","volume":"26","author":"G Katinios","year":"2020","unstructured":"Katinios G, Casado-Bedmar M, Walter SA, Vicario M, Gonz\u00e1lez-Castro AM, Bednarska O, S\u00f6derholm JD, Hjortswang H, Keita \u00c5V (2020) Increased colonic epithelial permeability and mucosal eosinophilia in ulcerative colitis in remission compared with irritable bowel syndrome and health. Inflamm Bowel Dis 26(7):974\u2013984. https:\/\/doi.org\/10.1093\/ibd\/izz328","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"3844_CR109","doi-asserted-by":"publisher","first-page":"513","DOI":"10.7326\/0003-4819-107-4-513","volume":"107","author":"HJ Kaufmann","year":"1987","unstructured":"Kaufmann HJ, Taubin HL (1987) Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med 107(4):513\u2013516. https:\/\/doi.org\/10.7326\/0003-4819-107-4-513","journal-title":"Ann Intern Med"},{"issue":"8","key":"3844_CR110","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1097\/MIB.0000000000000468","volume":"21","author":"LM Keubler","year":"2015","unstructured":"Keubler LM, Buettner M, H\u00e4ger C, Bleich A (2015) A multihit model: colitis lessons from the interleukin-10\u2013deficient mouse. Inflamm Bowel Dis 21(8):1967\u20131975. https:\/\/doi.org\/10.1097\/MIB.0000000000000468","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"3844_CR111","first-page":"169","volume":"14","author":"MA Khan","year":"2018","unstructured":"Khan MA, Howden CW (2018) The role of proton pump inhibitors in the management of upper gastrointestinal disorders. Gastroenterol Hepatol (n y) 14(3):169\u2013175","journal-title":"Gastroenterol Hepatol (n y)"},{"issue":"2","key":"3844_CR112","first-page":"295","volume":"93","author":"AJ Khan","year":"1979","unstructured":"Khan AJ, Evans HE, Glass L, Khan P, Chang CT, Nair SR (1979) Abnormal neutrophil chemotaxis and random migration induced by aminoglycoside antibiotics. J Lab Clin Med 93(2):295\u2013300","journal-title":"J Lab Clin Med"},{"issue":"2","key":"3844_CR113","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.cgh.2016.10.024","volume":"15","author":"S Khanna","year":"2017","unstructured":"Khanna S, Shin A, Kelly CP (2017) Management of clostridium difficile infection in inflammatory bowel disease: expert review from the clinical practice updates Committee of the AGA Institute. Clin Gastroenterol Hepatol 15(2):166\u2013174. https:\/\/doi.org\/10.1016\/j.cgh.2016.10.024","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3844_CR114","first-page":"102","volume":"70","author":"JB Kirsner","year":"1957","unstructured":"Kirsner JB, Elchlepp J (1957) The production of an experimental ulcerative colitis in rabbits. Trans Assoc Am Physicians 70:102\u2013119","journal-title":"Trans Assoc Am Physicians"},{"issue":"8","key":"3844_CR115","first-page":"511","volume":"11","author":"K Knight-Sepulveda","year":"2015","unstructured":"Knight-Sepulveda K, Kais S, Santaolalla R, Abreu MT (2015) Diet and inflammatory bowel disease. Gastroenterol Hepatol (n y) 11(8):511\u2013520","journal-title":"Gastroenterol Hepatol (n y)"},{"issue":"5","key":"3844_CR116","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1002\/ibd.21557","volume":"17","author":"I Koboziev","year":"2011","unstructured":"Koboziev I, Karlsson F, Zhang S, Grisham MB (2011) Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies. Inflamm Bowel Dis 17(5):1229\u20131245. https:\/\/doi.org\/10.1002\/ibd.21557","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"3844_CR117","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1172\/JCI10956","volume":"107","author":"MM Kosiewicz","year":"2001","unstructured":"Kosiewicz MM, Nast CC, Krishnan A, Rivera-Nieves J, Moskaluk CA, Matsumoto S, Kozaiwa K, Cominelli F (2001) Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn\u2019s disease. J Clin Invest 107(6):695\u2013702. https:\/\/doi.org\/10.1172\/JCI10956","journal-title":"J Clin Invest"},{"issue":"11","key":"3844_CR118","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1158\/1078-0432.CCR-06-2414","volume":"13","author":"IELM Kuppens","year":"2007","unstructured":"Kuppens IELM, Witteveen EO, Jewell RC, Radema SA, Paul EM, Mangum SG, Beijnen JH, Voest EE, Schellens JHM (2007) A phase I, randomized, open-label, parallel-cohort, dose-finding study of Elacridar (GF120918) and oral topotecan in cancer patients. Clin Cancer Res 13(11):3276\u20133285. https:\/\/doi.org\/10.1158\/1078-0432.CCR-06-2414","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3844_CR119","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1038\/s41467-022-35309-y","volume":"13","author":"YH Kwon","year":"2022","unstructured":"Kwon YH, Banskota S, Wang H, Rossi L, Grondin JA, Syed SA, Yousefi Y, Schertzer JD, Morrison KM, Wade MG et al (2022) Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nat Commun 13(1):7617. https:\/\/doi.org\/10.1038\/s41467-022-35309-y","journal-title":"Nat Commun"},{"key":"3844_CR120","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.envpol.2016.08.039","volume":"218","author":"K-P Lai","year":"2016","unstructured":"Lai K-P, Chung Y-T, Li R, Wan H-T, Wong CK-C (2016) Bisphenol A alters gut microbiome: comparative metagenomics analysis. Environ Pollut 218:923\u2013930. https:\/\/doi.org\/10.1016\/j.envpol.2016.08.039","journal-title":"Environ Pollut"},{"issue":"3","key":"3844_CR121","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3390\/cancers15030871","volume":"15","author":"V Laredo","year":"2023","unstructured":"Laredo V, Garc\u00eda-Mateo S, Mart\u00ednez-Dom\u00ednguez SJ, de la Cruz JL, Gargallo-Puyuelo CJ, Gomoll\u00f3n F (2023) Risk of cancer in patients with inflammatory bowel diseases and keys for patient management. Cancers 15(3):871. https:\/\/doi.org\/10.3390\/cancers15030871","journal-title":"Cancers"},{"issue":"2","key":"3844_CR122","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jcmgh.2018.09.002","volume":"7","author":"F Laudisi","year":"2019","unstructured":"Laudisi F, Di Fusco D, Dinallo V, Stolfi C, Di Grazia A, Marafini I, Colantoni A, Ortenzi A, Alteri C, Guerrieri F et al (2019) The food additive maltodextrin promotes endoplasmic reticulum stress-driven mucus depletion and exacerbates intestinal inflammation. Cell Mol Gastroenterol Hepatol 7(2):457\u2013473. https:\/\/doi.org\/10.1016\/j.jcmgh.2018.09.002","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"3844_CR123","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cgh.2019.07.005","volume":"18","author":"C Le Berre","year":"2020","unstructured":"Le Berre C, Ananthakrishnan AN, Danese S, Singh S, Peyrin-Biroulet L (2020) Ulcerative colitis and Crohn\u2019s disease have similar burden and goals for treatment. Clin Gastroenterol Hepatol 18(1):14\u201323. https:\/\/doi.org\/10.1016\/j.cgh.2019.07.005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"#cr-split#-3844_CR124.1","unstructured":"Lea T. 2015. Caco-2 Cell Line. In: Verhoeckx K, Cotter P, L\u00f3pez-Exp\u00f3sito I, Kleiveland C, Lea T, Mackie A, Requena T, Swiatecka D, Wichers H, editors (2022) The Impact of Food Bioactives on Health: in vitro and ex vivo models [Internet]. Cham (CH): Springer"},{"key":"#cr-split#-3844_CR124.2","unstructured":"[accessed 2022 Nov 30]. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK500149\/"},{"issue":"3","key":"3844_CR125","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/ijms19030730","volume":"19","author":"GR Lee","year":"2018","unstructured":"Lee GR (2018) The balance of Th17 versus treg cells in autoimmunity. Int J Mol Sci 19(3):730. https:\/\/doi.org\/10.3390\/ijms19030730","journal-title":"Int J Mol Sci"},{"issue":"8","key":"3844_CR126","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/imj.12179","volume":"43","author":"T Lee","year":"2013","unstructured":"Lee T, Russell L, Deng M, Gibson PR (2013) Association of doxycycline use with the development of gastroenteritis, irritable bowel syndrome and inflammatory bowel disease in A ustralians deployed abroad. Intern Med J 43(8):919\u2013926","journal-title":"Intern Med J"},{"issue":"11","key":"3844_CR127","doi-asserted-by":"publisher","first-page":"6013","DOI":"10.3390\/ijms22116013","volume":"22","author":"C Lee","year":"2021","unstructured":"Lee C, Hong S-N, Kim E-R, Chang D-K, Kim Y-H (2021) Epithelial Regeneration Ability of Crohn\u2019s Disease Assessed Using Patient-Derived Intestinal Organoids. Int J Mol Sci 22(11):6013. https:\/\/doi.org\/10.3390\/ijms22116013","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3844_CR128","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12967-019-1976-2","volume":"17","author":"CHC Leenaars","year":"2019","unstructured":"Leenaars CHC, Kouwenaar C, Stafleu FR, Bleich A, Ritskes-Hoitinga M, De Vries RBM, Meijboom FLB (2019) Animal to human translation: a systematic scoping review of reported concordance rates. J Transl Med 17(1):223. https:\/\/doi.org\/10.1186\/s12967-019-1976-2","journal-title":"J Transl Med"},{"issue":"15","key":"3844_CR129","first-page":"2838","volume":"19","author":"V Leso","year":"2015","unstructured":"Leso V, Ricciardi W, Iavicoli I (2015) Occupational risk factors in inflammatory bowel disease. Eur Rev Med Pharmacol Sci 19(15):2838\u20132851","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"3844_CR130","doi-asserted-by":"publisher","first-page":"13186","DOI":"10.1038\/s41598-021-92574-5","volume":"11","author":"P Lian","year":"2021","unstructured":"Lian P, Braber S, Varasteh S, Wichers HJ, Folkerts G (2021) Hypoxia and heat stress affect epithelial integrity in a Caco-2\/HT-29 co-culture. Sci Rep 11(1):13186. https:\/\/doi.org\/10.1038\/s41598-021-92574-5","journal-title":"Sci Rep"},{"issue":"6","key":"3844_CR131","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s13197-020-04242-7","volume":"57","author":"Q Liang","year":"2020","unstructured":"Liang Q, Ren X, Chalamaiah M, Ma H (2020) Simulated gastrointestinal digests of corn protein hydrolysate alleviate inflammation in caco-2 cells and a mouse model of colitis. J Food Sci Technol 57(6):2079\u20132088. https:\/\/doi.org\/10.1007\/s13197-020-04242-7","journal-title":"J Food Sci Technol"},{"key":"3844_CR132","doi-asserted-by":"publisher","unstructured":"Libertucci J, Dutta U, Kaur S, Jury J, Rossi L, Fontes ME, Shajib MS, Khan WI, Surette MG, Verdu EF, Armstrong D (2018) Inflammation-related differences in mucosa-associated microbiota and intestinal barrier function in colonic Crohn\u2019s disease. Am J Physiol-Gastrointestal and Liver Physiology. 315(3):G420\u2013G431. https:\/\/doi.org\/10.1152\/ajpgi.00411.2017","DOI":"10.1152\/ajpgi.00411.2017"},{"issue":"6","key":"3844_CR133","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1038\/s41385-018-0018-3","volume":"11","author":"X Lin","year":"2018","unstructured":"Lin X, Sun Q, Zhou L, He M, Dong X, Lai M, Liu M, Su Y, Jia C, Han Z et al (2018) Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses. Mucosal Immunol 11(6):1663\u20131673. https:\/\/doi.org\/10.1038\/s41385-018-0018-3","journal-title":"Mucosal Immunol"},{"issue":"7","key":"3844_CR134","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100481R","volume":"35","author":"R Linares","year":"2021","unstructured":"Linares R, Fern\u00e1ndez MF, Guti\u00e9rrez A, Garc\u00eda-Villalba R, Su\u00e1rez B, Zapater P, Mart\u00ednez-Bl\u00e1zquez JA, Caparr\u00f3s E, Tom\u00e1s-Barber\u00e1n FA, Franc\u00e9s R (2021) Endocrine disruption in Crohn\u2019s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products. FASEB J 35(7):e21697. https:\/\/doi.org\/10.1096\/fj.202100481R","journal-title":"FASEB J"},{"issue":"4","key":"3844_CR135","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1053\/j.gastro.2017.11.030","volume":"154","author":"SR Llewellyn","year":"2018","unstructured":"Llewellyn SR, Britton GJ, Contijoch EJ, Vennaro OH, Mortha A, Colombel J-F, Grinspan A, Clemente JC, Merad M, Faith JJ (2018) Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice. Gastroenterology 154(4):1037-1046.e2. https:\/\/doi.org\/10.1053\/j.gastro.2017.11.030","journal-title":"Gastroenterology"},{"issue":"6","key":"3844_CR136","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","volume":"126","author":"EV Loftus","year":"2004","unstructured":"Loftus EV (2004) Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126(6):1504\u20131517. https:\/\/doi.org\/10.1053\/j.gastro.2004.01.063","journal-title":"Gastroenterology"},{"issue":"6","key":"3844_CR137","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.cgh.2009.12.022","volume":"8","author":"L Lombardo","year":"2010","unstructured":"Lombardo L, Foti M, Ruggia O, Chiecchio A (2010) Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy. Clin Gastroenterol Hepatol 8(6):504\u2013508","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"3844_CR138","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/00042737-200102000-00003","volume":"13","author":"MCE Lomer","year":"2001","unstructured":"Lomer MCE, Harvey RSJ, Evans SM, Thompson RPH, Powell JJ (2001) Efficacy and tolerability of a low microparticle diet in a double blind, randomized, pilot study in Crohn\u2019s disease. Eur J Gastroenterol Hepatol 13(2):101","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"3844_CR139","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1079\/bjn20041276","volume":"92","author":"MCE Lomer","year":"2004","unstructured":"Lomer MCE, Hutchinson C, Volkert S, Greenfield SM, Catterall A, Thompson RPH, Powell JJ (2004) Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn\u2019s disease. Br J Nutr 92(6):947\u2013955. https:\/\/doi.org\/10.1079\/bjn20041276","journal-title":"Br J Nutr"},{"issue":"2","key":"3844_CR140","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","volume":"42","author":"Y-C Lu","year":"2008","unstructured":"Lu Y-C, Yeh W-C, Ohashi PS (2008) LPS\/TLR4 signal transduction pathway. Cytokine 42(2):145\u2013151. https:\/\/doi.org\/10.1016\/j.cyto.2008.01.006","journal-title":"Cytokine"},{"issue":"4","key":"3844_CR141","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/j.1572-0241.2002.05608.x","volume":"97","author":"U Mahadevan","year":"2002","unstructured":"Mahadevan U, Loftus EV Jr, Tremaine WJ, Sandborn WJ (2002) Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease. Am J Gastroenterol 97(4):910\u2013914","journal-title":"Am J Gastroenterol"},{"issue":"7351","key":"3844_CR142","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10208","volume":"474","author":"KJ Maloy","year":"2011","unstructured":"Maloy KJ, Powrie F (2011) Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474(7351):298\u2013306. https:\/\/doi.org\/10.1038\/nature10208","journal-title":"Nature"},{"issue":"3","key":"3844_CR143","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.toxicon.2010.04.016","volume":"56","author":"M Maresca","year":"2010","unstructured":"Maresca M, Fantini J (2010) Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases. Toxicon 56(3):282\u2013294. https:\/\/doi.org\/10.1016\/j.toxicon.2010.04.016","journal-title":"Toxicon"},{"key":"3844_CR144","doi-asserted-by":"publisher","unstructured":"Marescotti D, Lo Sasso G, Guerrera D, Renggli K, Ruiz Castro PA, Piault R, Jaquet V, Moine F, Luettich K, Frentzel S, et al. 2021. Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds. Frontiers in Pharmacology [Internet]. [accessed 2023 Oct 4] 12. https:\/\/www.frontiersin.org\/articles\/https:\/\/doi.org\/10.3389\/fphar.2021.639716","DOI":"10.3389\/fphar.2021.639716"},{"key":"3844_CR145","doi-asserted-by":"crossref","unstructured":"Margolis DJ, Fanelli M, Hoffstad O, Lewis JD. 2010. Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease. Official journal of the American College of Gastroenterology| ACG. 105(12):2610\u20132616.","DOI":"10.1038\/ajg.2010.303"},{"issue":"1","key":"3844_CR146","doi-asserted-by":"publisher","first-page":"12261","DOI":"10.1038\/s41598-018-30526-2","volume":"8","author":"D Maria-Ferreira","year":"2018","unstructured":"Maria-Ferreira D, Nascimento AM, Cipriani TR, Santana-Filho AP, da Watanabe P, S, Sant\u00b4Ana D de MG, Luciano FB, Bocate KCP, van den Wijngaard RM, Werner MF de P, Baggio CH. (2018) Rhamnogalacturonan, a chemically-defined polysaccharide, improves intestinal barrier function in DSS-induced colitis in mice and human Caco-2 cells. Sci Rep 8(1):12261. https:\/\/doi.org\/10.1038\/s41598-018-30526-2","journal-title":"Sci Rep"},{"issue":"5","key":"3844_CR147","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.stem.2021.04.005","volume":"28","author":"A Marsee","year":"2021","unstructured":"Marsee A, Roos FJM, Verstegen MMA, Marsee A, Roos F, Verstegen M, Clevers H, Vallier L, Takebe T, Huch M et al (2021) Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. Cell Stem Cell 28(5):816\u2013832. https:\/\/doi.org\/10.1016\/j.stem.2021.04.005","journal-title":"Cell Stem Cell"},{"key":"3844_CR148","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bbrc.2021.12.111","volume":"592","author":"H Matsuda","year":"2022","unstructured":"Matsuda H, Nibe-Shirakihara Y, Tamura A, Aonuma E, Arakawa S, Otsubo K, Nemoto Y, Nagaishi T, Tsuchiya K, Shimizu S et al (2022) Nickel particles are present in Crohn\u2019s disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. Biochem Biophys Res Commun 592:74\u201380. https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.111","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3844_CR149","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3164\/jcbn.10-79","volume":"48","author":"H Matsui","year":"2011","unstructured":"Matsui H, Shimokawa O, Kaneko T, Nagano Y, Rai K, Hyodo I (2011) The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine. J Clin Biochem Nutr 48(2):107\u2013111. https:\/\/doi.org\/10.3164\/jcbn.10-79","journal-title":"J Clin Biochem Nutr"},{"issue":"11","key":"3844_CR150","first-page":"3379","volume":"5","author":"JM Meerum Terwogt","year":"1999","unstructured":"Meerum Terwogt JM, Malingr\u00e9 MM, Beijnen JH, ten Bokkel Huinink WW, Rosing H, Koopman FJ, van Tellingen O, Swart M, Schellens JH (1999) Coadministration of oral cyclosporin A enables oral therapy with paclitaxel. Clin Cancer Res 5(11):3379\u20133384","journal-title":"Clin Cancer Res"},{"issue":"7","key":"3844_CR151","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1172\/JCI35073","volume":"118","author":"LB Meira","year":"2008","unstructured":"Meira LB, Bugni JM, Green SL, Lee C-W, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL et al (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest 118(7):2516\u20132525. https:\/\/doi.org\/10.1172\/JCI35073","journal-title":"J Clin Invest"},{"key":"3844_CR152","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112601","volume":"157","author":"R Mesnage","year":"2021","unstructured":"Mesnage R, Brandsma I, Moelijker N, Zhang G, Antoniou MN (2021) Genotoxicity evaluation of 2,4-D, dicamba and glyphosate alone or in combination with cell reporter assays for DNA damage, oxidative stress and unfolded protein response. Food Chem Toxicol 157:112601. https:\/\/doi.org\/10.1016\/j.fct.2021.112601","journal-title":"Food Chem Toxicol"},{"issue":"9","key":"3844_CR153","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1097\/01.mcg.0000139057.05297.d6","volume":"38","author":"AM Meyer","year":"2004","unstructured":"Meyer AM, Ramzan NN, Loftus EV Jr, Heigh RI, Leighton JA (2004) The diagnostic yield of stool pathogen studies during relapses of inflammatory bowel disease. J Clin Gastroenterol 38(9):772\u2013775","journal-title":"J Clin Gastroenterol"},{"issue":"S2","key":"3844_CR154","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/obr.12107","volume":"14","author":"CA Monteiro","year":"2013","unstructured":"Monteiro CA, Moubarac J-C, Cannon G, Ng SW, Popkin B (2013) Ultra-processed products are becoming dominant in the global food system. Obes Rev 14(S2):21\u201328. https:\/\/doi.org\/10.1111\/obr.12107","journal-title":"Obes Rev"},{"issue":"5","key":"3844_CR155","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1017\/S1368980018003762","volume":"22","author":"CA Monteiro","year":"2019","unstructured":"Monteiro CA, Cannon G, Levy RB, Moubarac J-C, Louzada ML, Rauber F, Khandpur N, Cediel G, Neri D, Martinez-Steele E et al (2019) Ultra-processed foods: what they are and how to identify them. Public Health Nutr 22(5):936\u2013941. https:\/\/doi.org\/10.1017\/S1368980018003762","journal-title":"Public Health Nutr"},{"issue":"4","key":"3844_CR156","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.xphs.2019.12.015","volume":"109","author":"D Nakai","year":"2020","unstructured":"Nakai D, Miyake M, Hashimoto A (2020) Comparison of the Intestinal Drug Permeation and Accumulation Between Normal Human Intestinal Tissues and Human Intestinal Tissues With Ulcerative Colitis. J Pharm Sci 109(4):1623\u20131626. https:\/\/doi.org\/10.1016\/j.xphs.2019.12.015","journal-title":"J Pharm Sci"},{"issue":"6","key":"3844_CR157","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.stemcr.2018.10.019","volume":"11","author":"R Negoro","year":"2018","unstructured":"Negoro R, Takayama K, Kawai K, Harada K, Sakurai F, Hirata K, Mizuguchi H (2018) Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies. Stem Cell Reports 11(6):1539\u20131550. https:\/\/doi.org\/10.1016\/j.stemcr.2018.10.019","journal-title":"Stem Cell Reports"},{"issue":"5","key":"3844_CR158","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","volume":"14","author":"MF Neurath","year":"2014","unstructured":"Neurath MF (2014) Cytokines in inflammatory bowel disease. Nat Rev Immunol 14(5):329\u2013342. https:\/\/doi.org\/10.1038\/nri3661","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"3844_CR159","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1093\/ecco-jcc\/jjac168","volume":"17","author":"M Nighot","year":"2023","unstructured":"Nighot M, Liao P-L, Morris N, McCarthy D, Dharmaprakash V, Ullah Khan I, Dalessio S, Saha K, Ganapathy AS, Wang A (2023) Long-Term Use of Proton Pump Inhibitors Disrupts Intestinal Tight Junction Barrier and Exaggerates Experimental Colitis. Journal of Crohn\u2019s and Colitis 17(4):565\u2013579","journal-title":"Journal of Crohn\u2019s and Colitis"},{"issue":"3","key":"3844_CR160","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00204-022-03234-0","volume":"96","author":"KS Nitsche","year":"2022","unstructured":"Nitsche KS, M\u00fcller I, Malcomber S, Carmichael PL, Bouwmeester H (2022) Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review. Arch Toxicol 96(3):711\u2013741. https:\/\/doi.org\/10.1007\/s00204-022-03234-0","journal-title":"Arch Toxicol"},{"issue":"3","key":"3844_CR161","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3748\/wjg.v22.i3.1078","volume":"22","author":"O Nitzan","year":"2016","unstructured":"Nitzan O, Elias M, Peretz A, Saliba W (2016) Role of antibiotics for treatment of inflammatory bowel disease. World J Gastroenterol 22(3):1078\u20131087. https:\/\/doi.org\/10.3748\/wjg.v22.i3.1078","journal-title":"World J Gastroenterol"},{"issue":"6","key":"3844_CR162","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3390\/metabo13060739","volume":"13","author":"H Niu","year":"2023","unstructured":"Niu H, Liu S, Jiang Y, Hu Y, Li Y, He L, Xing M, Li X, Wu L, Chen Z et al (2023) Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota. Metabolites 13(6):739. https:\/\/doi.org\/10.3390\/metabo13060739","journal-title":"Metabolites"},{"issue":"8","key":"3844_CR163","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1111\/j.1572-0241.2000.02241.x","volume":"95","author":"O\u2019brien J,","year":"2000","unstructured":"O\u2019brien J, (2000) Nonsteroidal anti-inflammatory drugs in patients with inflammatory bowel disease. Off J Am Coll Gastroenterol ACG 95(8):1859\u20131861","journal-title":"Off J Am Coll Gastroenterol ACG"},{"issue":"6837","key":"3844_CR164","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH et al (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease. Nature 411(6837):603\u2013606. https:\/\/doi.org\/10.1038\/35079114","journal-title":"Nature"},{"key":"3844_CR165","doi-asserted-by":"publisher","unstructured":"Ostanin DV, Bao J, Koboziev I, Gray L, Robinson-Jackson SA, Kosloski-Davidson M, Price VH, Grisham MB (2009) T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am J Physiol-Gastrointest Liver Physiol. 296(2):G135\u2013G146. https:\/\/doi.org\/10.1152\/ajpgi.90462.2008","DOI":"10.1152\/ajpgi.90462.2008"},{"issue":"Suppl 2","key":"3844_CR166","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1093\/cdn\/nzaa067_058","volume":"4","author":"M Paschall","year":"2020","unstructured":"Paschall M, Seo Y-A, Choi E (2020) Low dietary manganese levels exacerbate experimental colitis in mice. Curr Dev Nutr 4(Suppl 2):1831. https:\/\/doi.org\/10.1093\/cdn\/nzaa067_058","journal-title":"Curr Dev Nutr"},{"issue":"900","key":"3844_CR167","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1136\/pmj.76.900.611","volume":"76","author":"S Pathmakanthan","year":"2000","unstructured":"Pathmakanthan S, Hawkey CJ (2000) A lay doctor\u2019s guide to the inflammatory process in the gastrointestinal tract. Postgrad Med J 76(900):611\u2013617. https:\/\/doi.org\/10.1136\/pmj.76.900.611","journal-title":"Postgrad Med J"},{"issue":"1","key":"3844_CR168","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s44164-023-00047-y","volume":"2","author":"MB Paul","year":"2023","unstructured":"Paul MB, Schlief M, Daher H, Braeuning A, Sieg H, B\u00f6hmert L (2023) A human Caco-2-based co-culture model of the inflamed intestinal mucosa for particle toxicity studies. In Vitro Models 2(1):43\u201364. https:\/\/doi.org\/10.1007\/s44164-023-00047-y","journal-title":"In Vitro Models"},{"issue":"9","key":"3844_CR169","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1007\/s00204-020-02817-z","volume":"94","author":"D Payros","year":"2020","unstructured":"Payros D, M\u00e9nard S, Laffitte J, Neves M, Tremblay-Franco M, Luo S, Fouche E, Snini SP, Theodorou V, Pinton P, Oswald IP (2020) The food contaminant, deoxynivalenol, modulates the Thelper\/Treg balance and increases inflammatory bowel diseases. Arch Toxicol 94(9):3173\u20133184. https:\/\/doi.org\/10.1007\/s00204-020-02817-z","journal-title":"Arch Toxicol"},{"issue":"11","key":"3844_CR170","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1093\/ecco-jcc\/jjw088","volume":"10","author":"C Pereira","year":"2016","unstructured":"Pereira C, Coelho R, Gr\u00e1cio D, Dias C, Silva M, Peixoto A, Lopes P, Costa C, Teixeira JP, Macedo G, Magro F (2016) DNA damage and oxidative DNA damage in inflammatory bowel disease. J Crohn\u2019s Colitis 10(11):1316\u20131323. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjw088","journal-title":"J Crohn\u2019s Colitis"},{"issue":"3","key":"3844_CR171","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/mi.2013.78","volume":"7","author":"G Pineton de Chambrun","year":"2014","unstructured":"Pineton de Chambrun G, Body-Malapel M, Frey-Wagner I, Djouina M, Deknuydt F, Atrott K, Esquerre N, Altare F, Neut C, Arrieta MC et al (2014) Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice. Mucosal Immunol 7(3):589\u2013601. https:\/\/doi.org\/10.1038\/mi.2013.78","journal-title":"Mucosal Immunol"},{"issue":"1","key":"3844_CR172","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00280-004-0854-6","volume":"55","author":"AST Planting","year":"2005","unstructured":"Planting AST, Sonneveld P, van der Gaast A, Sparreboom A, van der Burg MEL, Luyten GPM, de Leeuw K, de Boer-Dennert M, Wissel PS, Jewell RC et al (2005) A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors. Cancer Chemother Pharmacol 55(1):91\u201399. https:\/\/doi.org\/10.1007\/s00280-004-0854-6","journal-title":"Cancer Chemother Pharmacol"},{"issue":"10","key":"3844_CR173","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1038\/s41596-021-00589-z","volume":"16","author":"J Puschhof","year":"2021","unstructured":"Puschhof J, Pleguezuelos-Manzano C, Martinez-Silgado A, Akkerman N, Saftien A, Boot C, de Waal A, Beumer J, Dutta D, Heo I, Clevers H (2021) Intestinal organoid cocultures with microbes. Nat Protoc 16(10):4633\u20134649. https:\/\/doi.org\/10.1038\/s41596-021-00589-z","journal-title":"Nat Protoc"},{"issue":"7","key":"3844_CR174","doi-asserted-by":"publisher","first-page":"826","DOI":"10.3109\/00365521.2014.919018","volume":"49","author":"H Qiu","year":"2014","unstructured":"Qiu H, Sun X, Sun M, He C, Li Z, Liu Z (2014) Serum bacterial toxins are related to the progression of inflammatory bowel disease. Scand J Gastroenterol 49(7):826\u2013833. https:\/\/doi.org\/10.3109\/00365521.2014.919018","journal-title":"Scand J Gastroenterol"},{"issue":"24","key":"3844_CR175","doi-asserted-by":"publisher","first-page":"13472","DOI":"10.3390\/ijms222413472","volume":"22","author":"S Rahman","year":"2021","unstructured":"Rahman S, Ghiboub M, Donkers JM, van de Steeg E, van Tol EAF, Hakvoort TBM, de Jonge WJ (2021) The progress of intestinal epithelial models from cell lines to Gut-on-chip. Int J Mol Sci 22(24):13472. https:\/\/doi.org\/10.3390\/ijms222413472","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3844_CR176","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/microorganisms10010167","volume":"10","author":"P Raoul","year":"2022","unstructured":"Raoul P, Cintoni M, Palombaro M, Basso L, Rinninella E, Gasbarrini A, Mele MC (2022) Food Additives, a Key Environmental Factor in the Development of IBD through Gut Dysbiosis. Microorganisms 10(1):167. https:\/\/doi.org\/10.3390\/microorganisms10010167","journal-title":"Microorganisms"},{"issue":"2","key":"3844_CR177","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/ibd\/izx014","volume":"24","author":"C Reinoso Webb","year":"2018","unstructured":"Reinoso Webb C, den Bakker H, Koboziev I, Jones-Hall Y, Rao Kottapalli K, Ostanin D, Furr KL, Mu Q, Luo XM, Grisham MB (2018) Differential susceptibility to T cell-induced colitis in mice: role of the intestinal microbiota. Inflamm Bowel Dis 24(2):361\u2013379. https:\/\/doi.org\/10.1093\/ibd\/izx014","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"3844_CR178","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1039\/C9AY02038A","volume":"12","author":"A Richardson","year":"2020","unstructured":"Richardson A, Schwerdtfeger LA, Eaton D, Mclean I, Henry CS, Tobet SA (2020) A microfluidic organotypic device for culture of mammalian intestines ex vivo. Anal Methods 12(3):297\u2013303. https:\/\/doi.org\/10.1039\/C9AY02038A","journal-title":"Anal Methods"},{"issue":"4","key":"3844_CR179","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1053\/gast.2003.50148","volume":"124","author":"J Rivera-Nieves","year":"2003","unstructured":"Rivera-Nieves J, Bamias G, Vidrich A, Marini M, Pizarro TT, McDuffie MJ, Moskaluk CA, Cohn SM, Cominelli F (2003) Emergence of perianal fistulizing disease in the SAMP1\/YitFc mouse, a spontaneous model of chronic ileitis. Gastroenterology 124(4):972\u2013982. https:\/\/doi.org\/10.1053\/gast.2003.50148","journal-title":"Gastroenterology"},{"issue":"5","key":"3844_CR180","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.3390\/nu11051033","volume":"11","author":"F Rizzello","year":"2019","unstructured":"Rizzello F, Spisni E, Giovanardi E, Imbesi V, Salice M, Alvisi P, Valerii MC, Gionchetti P (2019) Implications of the westernized diet in the onset and progression of IBD. Nutrients 11(5):1033. https:\/\/doi.org\/10.3390\/nu11051033","journal-title":"Nutrients"},{"issue":"5","key":"3844_CR181","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1093\/ibd\/izy060","volume":"24","author":"A Rodriguez-Palacios","year":"2018","unstructured":"Rodriguez-Palacios A, Harding A, Menghini P, Himmelman C, Retuerto M, Nickerson KP, Lam M, Croniger CM, McLean MH, Durum SK et al (2018) The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn\u2019s Disease-Like Ileitis. Inflamm Bowel Dis 24(5):1005\u20131020. https:\/\/doi.org\/10.1093\/ibd\/izy060","journal-title":"Inflamm Bowel Dis"},{"issue":"7","key":"3844_CR182","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1136\/gutjnl-2015-310297","volume":"66","author":"PA Ruiz","year":"2017","unstructured":"Ruiz PA, Mor\u00f3n B, Becker HM, Lang S, Atrott K, Spalinger MR, Scharl M, Wojtal KA, Fischbeck-Terhalle A, Frey-Wagner I et al (2017) Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome. Gut 66(7):1216\u20131224. https:\/\/doi.org\/10.1136\/gutjnl-2015-310297","journal-title":"Gut"},{"issue":"7937","key":"3844_CR183","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/s41586-022-05308-6","volume":"611","author":"LM Sanmarco","year":"2022","unstructured":"Sanmarco LM, Chao C-C, Wang Y-C, Kenison JE, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G et al (2022) Identification of environmental factors that promote intestinal inflammation. Nature 611(7937):801\u2013809. https:\/\/doi.org\/10.1038\/s41586-022-05308-6","journal-title":"Nature"},{"issue":"1","key":"3844_CR184","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/s41467-020-20351-5","volume":"12","author":"SK Sarvestani","year":"2021","unstructured":"Sarvestani SK, Signs S, Hu B, Yeu Y, Feng H, Ni Y, Hill DR, Fisher RC, Ferrandon S, DeHaan RK et al (2021) Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity. Nat Commun 12(1):262. https:\/\/doi.org\/10.1038\/s41467-020-20351-5","journal-title":"Nat Commun"},{"issue":"4","key":"3844_CR185","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s44164-022-00035-8","volume":"1","author":"S Schnur","year":"2022","unstructured":"Schnur S, Wahl V, Metz JK, Gillmann J, Hans F, Rotermund K, Z\u00e4h R-K, Br\u00fcck DA, Schneider M, Hittinger M (2022) Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay. In Vitro Models 1(4):365\u2013383. https:\/\/doi.org\/10.1007\/s44164-022-00035-8","journal-title":"In Vitro Models"},{"issue":"3\u20135","key":"3844_CR186","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jsbmb.2011.08.007","volume":"127","author":"TT Schug","year":"2011","unstructured":"Schug TT, Janesick A, Blumberg B, Heindel JJ (2011) Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Biol 127(3\u20135):204\u2013215. https:\/\/doi.org\/10.1016\/j.jsbmb.2011.08.007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3844_CR187","doi-asserted-by":"publisher","first-page":"175628482110202","DOI":"10.1177\/17562848211020285","volume":"14","author":"K Sehgal","year":"2021","unstructured":"Sehgal K, Yadav D, Khanna S (2021) The interplay of Clostridioides difficile infection and inflammatory bowel disease. Therap Adv Gastroenterol 14:17562848211020284. https:\/\/doi.org\/10.1177\/17562848211020285","journal-title":"Therap Adv Gastroenterol"},{"issue":"11","key":"3844_CR188","doi-asserted-by":"publisher","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","volume":"66","author":"RK Sellon","year":"1998","unstructured":"Sellon RK, Tonkonogy S, Schultz M, Dieleman LA, Grenther W, Balish E, Rennick DM, Sartor RB (1998) Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 66(11):5224\u20135231","journal-title":"Infect Immun"},{"key":"3844_CR189","doi-asserted-by":"publisher","unstructured":"Shafa M, Yang F, Fellner T, Rao MS, Baghbaderani BA (2018) Human-induced pluripotent stem cells manufactured using a current good manufacturing practice-compliant process differentiate into clinically relevant cells from three germ layers. Front Med. https:\/\/doi.org\/10.3389\/fmed.2018.00069","DOI":"10.3389\/fmed.2018.00069"},{"issue":"3","key":"3844_CR190","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/apha.12430","volume":"213","author":"M Shajib","year":"2015","unstructured":"Shajib M, Khan W (2015) The role of serotonin and its receptors in activation of immune responses and inflammation. Acta Physiol 213(3):561\u2013574","journal-title":"Acta Physiol"},{"issue":"11","key":"3844_CR191","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1007\/s42452-019-1485-1","volume":"1","author":"A Sharma","year":"2019","unstructured":"Sharma A, Kumar V, Shahzad B, Tanveer M, Sidhu GPS, Handa N, Kohli SK, Yadav P, Bali AS, Parihar RD et al (2019) Worldwide pesticide usage and its impacts on ecosystem. SN Appl Sci 1(11):1446. https:\/\/doi.org\/10.1007\/s42452-019-1485-1","journal-title":"SN Appl Sci"},{"issue":"12","key":"3844_CR192","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1038\/ajg.2010.398","volume":"105","author":"SY Shaw","year":"2010","unstructured":"Shaw SY, Blanchard JF, Bernstein CN (2010) Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease. Am J Gastroenterol 105(12):2687\u20132692. https:\/\/doi.org\/10.1038\/ajg.2010.398","journal-title":"Am J Gastroenterol"},{"key":"3844_CR193","unstructured":"Shawna Kraft P (2013) Chemotherapy-induced diarrhea: options for treatment and prevention [Internet]. https:\/\/jhoponline.com\/issue-archive\/2012-issues\/december-2012-vol-3-no-4\/15408-chemotherapy-unduced-diarrhea-options. Accessed 11 April 2024"},{"issue":"12","key":"3844_CR194","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1136\/gut.2011.239194","volume":"60","author":"YH Sheng","year":"2011","unstructured":"Sheng YH, Lourie R, Lind\u00e9n SK, Jeffery PL, Roche D, Tran TV, Png CW, Waterhouse N, Sutton P, Florin THJ, McGuckin MA (2011) The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut 60(12):1661\u20131670. https:\/\/doi.org\/10.1136\/gut.2011.239194","journal-title":"Gut"},{"issue":"45","key":"3844_CR195","doi-asserted-by":"publisher","first-page":"E10539","DOI":"10.1073\/pnas.1810819115","volume":"115","author":"W Shin","year":"2018","unstructured":"Shin W, Kim HJ (2018) Intestinal barrier dysfunction orchestrates the onset of inflammatory host\u2013microbiome cross-talk in a human gut inflammation-on-a-chip. Proc Natl Acad Sci 115(45):E10539\u2013E10547. https:\/\/doi.org\/10.1073\/pnas.1810819115","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"3844_CR196","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3390\/mi11070663","volume":"11","author":"YC Shin","year":"2020","unstructured":"Shin YC, Shin W, Koh D, Wu A, Ambrosini YM, Min S, Eckhardt SG, Fleming RYD, Kim S, Park S et al (2020) Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip. Micromachines 11(7):663. https:\/\/doi.org\/10.3390\/mi11070663","journal-title":"Micromachines"},{"issue":"3","key":"3844_CR197","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/s41596-021-00674-3","volume":"17","author":"W Shin","year":"2022","unstructured":"Shin W, Kim HJ (2022) 3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert. Nat Protoc 17(3):910\u2013939. https:\/\/doi.org\/10.1038\/s41596-021-00674-3","journal-title":"Nat Protoc"},{"issue":"3","key":"3844_CR198","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1365-2249.2007.03439.x","volume":"149","author":"M Shioya","year":"2007","unstructured":"Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y, Andoh A (2007) Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin Exp Immunol 149(3):480\u2013486. https:\/\/doi.org\/10.1111\/j.1365-2249.2007.03439.x","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"3844_CR199","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.cgh.2011.05.016","volume":"9","author":"S Singh","year":"2011","unstructured":"Singh S, Blanchard A, Walker JR, Graff LA, Miller N, Bernstein CN (2011) Common symptoms and stressors among individuals with inflammatory bowel diseases. Clin Gastroenterol Hepatol 9(9):769\u2013775. https:\/\/doi.org\/10.1016\/j.cgh.2011.05.016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3844_CR200","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.cyto.2015.10.008","volume":"77","author":"UP Singh","year":"2016","unstructured":"Singh UP, Singh NP, Murphy EA, Price RL, Fayad R, Nagarkatti M, Nagarkatti PS (2016) Chemokine and cytokine levels in inflammatory bowel disease patients. Cytokine 77:44\u201349. https:\/\/doi.org\/10.1016\/j.cyto.2015.10.008","journal-title":"Cytokine"},{"issue":"4","key":"3844_CR201","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nrc1318","volume":"4","author":"ST Sonis","year":"2004","unstructured":"Sonis ST (2004) The pathobiology of mucositis. Nat Rev Cancer 4(4):277\u2013284","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"3844_CR202","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1177\/1758834009355164","volume":"2","author":"A Stein","year":"2010","unstructured":"Stein A, Voigt W, Jordan K (2010) Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management. Ther Adv Med Oncol 2(1):51\u201363. https:\/\/doi.org\/10.1177\/1758834009355164","journal-title":"Ther Adv Med Oncol"},{"key":"3844_CR203","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.104989","volume":"137","author":"LJ Stevens","year":"2019","unstructured":"Stevens LJ, van Lipzig MMH, Erpelinck SLA, Pronk A, van Gorp J, Wortelboer HM, van de Steeg E (2019) A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes. Eur J Pharm Sci 137:104989. https:\/\/doi.org\/10.1016\/j.ejps.2019.104989","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"3844_CR204","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/19490976.2015.1017700","volume":"6","author":"J Suez","year":"2015","unstructured":"Suez J, Korem T, Zilberman-Schapira G, Segal E, Elinav E (2015) Non-caloric artificial sweeteners and the microbiome: findings and challenges. Gut Microbes 6(2):149\u2013155. https:\/\/doi.org\/10.1080\/19490976.2015.1017700","journal-title":"Gut Microbes"},{"issue":"1","key":"3844_CR205","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3109\/17435390.2015.1008065","volume":"10","author":"J Susewind","year":"2016","unstructured":"Susewind J, de Souza C-W, Repnik U, Collnot E-M, Schneider-Daum N, Griffiths GW, Lehr C-M (2016) A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials. Nanotoxicology 10(1):53\u201362. https:\/\/doi.org\/10.3109\/17435390.2015.1008065","journal-title":"Nanotoxicology"},{"issue":"1","key":"3844_CR206","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/s41598-021-04489-w","volume":"12","author":"A Tamargo","year":"2022","unstructured":"Tamargo A, Molinero N, Reinosa JJ, Alcolea-Rodriguez V, Portela R, Ba\u00f1ares MA, Fern\u00e1ndez JF, Moreno-Arribas MV (2022) PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion. Sci Rep 12(1):528. https:\/\/doi.org\/10.1038\/s41598-021-04489-w","journal-title":"Sci Rep"},{"issue":"12","key":"3844_CR207","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0289314","volume":"18","author":"C Tataru","year":"2023","unstructured":"Tataru C, Livni M, Marean-Reardon C, Franco MC, David M (2023) Cytokine induced inflammatory bowel disease model using organ-on-a-chip technology. PLoS ONE 18(12):e0289314. https:\/\/doi.org\/10.1371\/journal.pone.0289314","journal-title":"PLoS ONE"},{"issue":"1","key":"3844_CR208","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00365521.2017.1386711","volume":"53","author":"NA Theochari","year":"2018","unstructured":"Theochari NA, Stefanopoulos A, Mylonas KS, Economopoulos KP (2018) Antibiotics exposure and risk of inflammatory bowel disease: a systematic review. Scand J Gastroenterol 53(1):1\u20137","journal-title":"Scand J Gastroenterol"},{"issue":"8","key":"3844_CR209","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.3390\/ijms21082726","volume":"21","author":"M Toutounji","year":"2020","unstructured":"Toutounji M, Wanes D, El-Harakeh M, El-Sabban M, Rizk S, Naim HY (2020) Dextran sodium sulfate-induced impairment of protein trafficking and alterations in membrane composition in intestinal Caco-2 cell line. Int J Mol Sci 21(8):2726. https:\/\/doi.org\/10.3390\/ijms21082726","journal-title":"Int J Mol Sci"},{"issue":"3","key":"3844_CR210","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.cels.2020.02.008","volume":"10","author":"M Trapecar","year":"2020","unstructured":"Trapecar M, Communal C, Velazquez J, Maass CA, Huang Y-J, Schneider K, Wright CW, Butty V, Eng G, Yilmaz O et al (2020) Gut-Liver physiomimetics reveal paradoxical modulation of ibd-related inflammation by short-chain fatty acids. Cell Syst 10(3):223-239.e9. https:\/\/doi.org\/10.1016\/j.cels.2020.02.008","journal-title":"Cell Syst"},{"issue":"5","key":"3844_CR211","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1053\/j.gastro.2007.02.051","volume":"132","author":"M Tremelling","year":"2007","unstructured":"Tremelling M, Cummings F, Fisher SA, Mansfield J, Gwilliam R, Keniry A, Nimmo ER, Drummond H, Onnie CM, Prescott NJ et al (2007) IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology 132(5):1657\u20131664. https:\/\/doi.org\/10.1053\/j.gastro.2007.02.051","journal-title":"Gastroenterology"},{"issue":"1","key":"3844_CR212","doi-asserted-by":"publisher","first-page":"4363","DOI":"10.1038\/s41598-019-40776-3","volume":"9","author":"P Tu","year":"2019","unstructured":"Tu P, Gao B, Chi L, Lai Y, Bian X, Ru H, Lu K (2019) Subchronic low-dose 2,4-D exposure changed plasma acylcarnitine levels and induced gut microbiome perturbations in mice. Sci Rep 9(1):4363. https:\/\/doi.org\/10.1038\/s41598-019-40776-3","journal-title":"Sci Rep"},{"issue":"5","key":"3844_CR213","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","volume":"160","author":"D Turner","year":"2021","unstructured":"Turner D, Ricciuto A, Lewis A, D\u2019Amico F, Dhaliwal J, Griffiths AM, Bettenworth D, Sandborn WJ, Sands BE, Reinisch W et al (2021) STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology 160(5):1570\u20131583. https:\/\/doi.org\/10.1053\/j.gastro.2020.12.031","journal-title":"Gastroenterology"},{"issue":"12","key":"3844_CR214","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.2217\/pgs.09.128","volume":"10","author":"M Ufer","year":"2009","unstructured":"Ufer M, H\u00e4sler R, Jacobs G, Haenisch S, L\u00e4chelt S, Faltraco F, Sina C, Rosenstiel P, Nikolaus S, Schreiber S (2009) Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity. Pharmacogenomics 10(12):1941\u20131953","journal-title":"Pharmacogenomics"},{"issue":"4","key":"3844_CR215","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1124\/dmd.116.072231","volume":"45","author":"SFC Vaessen","year":"2017","unstructured":"Vaessen SFC, van Lipzig MMH, Pieters RHH, Krul CAM, Wortelboer HM, van de Steeg E (2017) Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells. Drug Metab Dispos 45(4):353\u2013360. https:\/\/doi.org\/10.1124\/dmd.116.072231","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"3844_CR216","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/s0962-8924(97)01215-4","volume":"8","author":"DJ Van Antwerp","year":"1998","unstructured":"Van Antwerp DJ, Martin SJ, Verma IM, Green DR (1998) Inhibition of TNF-induced apoptosis by NF-kappa B. Trends Cell Biol 8(3):107\u2013111. https:\/\/doi.org\/10.1016\/s0962-8924(97)01215-4","journal-title":"Trends Cell Biol"},{"issue":"8","key":"3844_CR217","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1097\/MIB.0000000000000392","volume":"21","author":"SR Vavricka","year":"2015","unstructured":"Vavricka SR, Schoepfer A, Scharl M, Lakatos PL, Navarini A, Rogler G (2015) Extraintestinal manifestations of inflammatory bowel disease. Inflamm Bowel Dis 21(8):1982\u20131992. https:\/\/doi.org\/10.1097\/MIB.0000000000000392","journal-title":"Inflamm Bowel Dis"},{"key":"3844_CR218","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1007\/s10620-013-2636-7","volume":"58","author":"N Verma","year":"2013","unstructured":"Verma N, Ahuja V, Paul J (2013) Profiling of ABC transporters during active ulcerative colitis and in vitro effect of inflammatory modulators. Dig Dis Sci 58:2282\u20132292","journal-title":"Dig Dis Sci"},{"issue":"6530","key":"3844_CR219","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1126\/science.abe5041","volume":"371","author":"AD Vethaak","year":"2021","unstructured":"Vethaak AD, Legler J (2021) Microplastics and human health. Science 371(6530):672\u2013674. https:\/\/doi.org\/10.1126\/science.abe5041","journal-title":"Science"},{"key":"3844_CR220","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tox.2013.08.011","volume":"312","author":"M Vinken","year":"2013","unstructured":"Vinken M (2013) The adverse outcome pathway concept: a pragmatic tool in toxicology. Toxicology 312:158\u2013165. https:\/\/doi.org\/10.1016\/j.tox.2013.08.011","journal-title":"Toxicology"},{"issue":"2","key":"3844_CR221","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/s0002-9440(10)62264-x","volume":"166","author":"F Wang","year":"2005","unstructured":"Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR (2005) Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 166(2):409\u2013419. https:\/\/doi.org\/10.1016\/s0002-9440(10)62264-x","journal-title":"Am J Pathol"},{"issue":"4","key":"3844_CR222","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1053\/j.gastro.2006.08.022","volume":"131","author":"F Wang","year":"2006","unstructured":"Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR (2006) IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 131(4):1153\u20131163. https:\/\/doi.org\/10.1053\/j.gastro.2006.08.022","journal-title":"Gastroenterology"},{"issue":"2","key":"3844_CR223","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.toxlet.2006.12.001","volume":"168","author":"J Wang","year":"2007","unstructured":"Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, Jia G, Gao Y, Li B, Sun J et al (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168(2):176\u2013185. https:\/\/doi.org\/10.1016\/j.toxlet.2006.12.001","journal-title":"Toxicol Lett"},{"issue":"1","key":"3844_CR224","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jcmgh.2017.02.011","volume":"4","author":"Y Wang","year":"2017","unstructured":"Wang Y, DiSalvo M, Gunasekara DB, Dutton J, Proctor A, Lebhar MS, Williamson IA, Speer J, Howard RL, Smiddy NM et al (2017) Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells. Cell Mol Gastroenterol Hepatol 4(1):165-182.e7. https:\/\/doi.org\/10.1016\/j.jcmgh.2017.02.011","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"3844_CR225","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1093\/ibd\/izy196","volume":"25","author":"X Wang","year":"2019","unstructured":"Wang X, Guo J, Liu Y, Yu H, Qin X (2019) Sucralose increased susceptibility to colitis in rats. Inflamm Bowel Dis 25(2):e3\u2013e4. https:\/\/doi.org\/10.1093\/ibd\/izy196","journal-title":"Inflamm Bowel Dis"},{"key":"3844_CR226","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113368","volume":"169","author":"S Wang","year":"2022","unstructured":"Wang S, Kang X, Alenius H, Wong SH, Karisola P, El-Nezami H (2022a) Oral exposure to Ag or TiO2 nanoparticles perturbed gut transcriptome and microbiota in a mouse model of ulcerative colitis. Food Chem Toxicol 169:113368. https:\/\/doi.org\/10.1016\/j.fct.2022.113368","journal-title":"Food Chem Toxicol"},{"key":"3844_CR227","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.113323","volume":"173","author":"J Wang","year":"2023","unstructured":"Wang J, Bakker W, de Haan L, Bouwmeester H (2023) Deoxynivalenol increases pro-inflammatory cytokine secretion and reduces primary bile acid transport in an inflamed intestinal in vitro co-culture model. Food Res Int 173:113323. https:\/\/doi.org\/10.1016\/j.foodres.2023.113323","journal-title":"Food Res Int"},{"key":"3844_CR228","doi-asserted-by":"publisher","unstructured":"Wang Y, Huang B, Jin T, Ocansey DKW, Jiang J, Mao F (2022) Intestinal fibrosis in inflammatory bowel disease and the prospects of mesenchymal stem cell therapy. Front Immunol 13. https:\/\/doi.org\/10.3389\/fimmu.2022.835005","DOI":"10.3389\/fimmu.2022.835005"},{"key":"3844_CR229","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ejps.2014.07.003","volume":"63","author":"J Westerhout","year":"2014","unstructured":"Westerhout J, van de Steeg E, Grossouw D, Zeijdner EE, Krul CAM, Verwei M, Wortelboer HM (2014) A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices. Eur J Pharm Sci 63:167\u2013177. https:\/\/doi.org\/10.1016\/j.ejps.2014.07.003","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"3844_CR230","doi-asserted-by":"publisher","first-page":"12918","DOI":"10.1038\/s41598-019-49452-y","volume":"9","author":"LJ Wilkins","year":"2019","unstructured":"Wilkins LJ, Monga M, Miller AW (2019) Defining dysbiosis for a cluster of chronic diseases. Sci Rep 9(1):12918. https:\/\/doi.org\/10.1038\/s41598-019-49452-y","journal-title":"Sci Rep"},{"issue":"1","key":"3844_CR231","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.gastro.2010.09.047","volume":"140","author":"MS Wilson","year":"2011","unstructured":"Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink-Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BL, Wynn TA (2011) Colitis and Intestinal Inflammation in IL10\u2212\/\u2212 Mice Results From IL-13R\u03b12\u2013Mediated Attenuation of IL-13 Activity. Gastroenterology 140(1):254-264.e2. https:\/\/doi.org\/10.1053\/j.gastro.2010.09.047","journal-title":"Gastroenterology"},{"issue":"9","key":"3844_CR232","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1124\/dmd.109.027367","volume":"37","author":"KA Wojtal","year":"2009","unstructured":"Wojtal KA, Eloranta JJ, Hruz P, Gutmann H, Drewe J, Staumann A, Beglinger C, Fried M, Kullak-Ublick GA, Vavricka SR (2009) Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients. Drug Metab Dispos 37(9):1871\u20131877","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"3844_CR233","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/ijms22010288","volume":"22","author":"MJ Workman","year":"2020","unstructured":"Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ (2020) Modeling Intestinal Epithelial Response to Interferon-\u03b3 in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. Int J Mol Sci 22(1):288. https:\/\/doi.org\/10.3390\/ijms22010288","journal-title":"Int J Mol Sci"},{"key":"3844_CR234","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.anaerobe.2013.03.011","volume":"24","author":"GD Wu","year":"2013","unstructured":"Wu GD, Bushmanc FD, Lewis JD (2013) Diet, the human gut microbiota, and IBD. Anaerobe 24:117\u2013120. https:\/\/doi.org\/10.1016\/j.anaerobe.2013.03.011","journal-title":"Anaerobe"},{"key":"3844_CR235","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00710","author":"L Xueting","year":"2020","unstructured":"Xueting L, Liu Y, Wang Y, Xue Li, Liu X, Guo M, Tan Y, Qin X, Wang X, Jiang M (2020) Sucralose promotes colitis-associated colorectal cancer risk in a murine model along with changes in microbiota. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2020.00710","journal-title":"Front Oncol"},{"issue":"6","key":"3844_CR236","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1080\/00365521.2018.1458146","volume":"53","author":"O Yakymenko","year":"2018","unstructured":"Yakymenko O, Schoultz I, Gullberg E, Str\u00f6m M, Almer S, Wallon C, Wang A, Keita \u00c5V, Campbell BJ, McKay DM, S\u00f6derholm JD (2018) Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn\u2019s disease via effects on epithelial lipid rafts. Scand J Gastroenterol 53(6):677\u2013684. https:\/\/doi.org\/10.1080\/00365521.2018.1458146","journal-title":"Scand J Gastroenterol"},{"key":"3844_CR237","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/659018","volume":"2015","author":"JK Yamamoto-Furusho","year":"2015","unstructured":"Yamamoto-Furusho JK, Asca\u00f1o-Guti\u00e9rrez I, Furuzawa-Carballeda J, Fonseca-Camarillo G (2015) Differential expression of MUC12, MUC16, and MUC20 in patients with active and remission ulcerative colitis. Mediators Inflamm 2015:659018. https:\/\/doi.org\/10.1155\/2015\/659018","journal-title":"Mediators Inflamm"},{"key":"3844_CR238","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8813558","volume":"2020","author":"J Yan","year":"2020","unstructured":"Yan J, Luo M, Chen Z, He B (2020) The Function and Role of the Th17\/Treg Cell Balance in Inflammatory Bowel Disease. J Immunol Res 2020:e8813558. https:\/\/doi.org\/10.1155\/2020\/8813558","journal-title":"J Immunol Res"},{"issue":"1","key":"3844_CR239","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1021\/acs.est.1c03924","volume":"56","author":"Z Yan","year":"2022","unstructured":"Yan Z, Liu Y, Zhang T, Zhang F, Ren H, Zhang Y (2022) Analysis of microplastics in human feces reveals a correlation between fecal microplastics and inflammatory bowel disease status. Environ Sci Technol 56(1):414\u2013421. https:\/\/doi.org\/10.1021\/acs.est.1c03924","journal-title":"Environ Sci Technol"},{"key":"3844_CR240","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.132160","volume":"287","author":"F Yin","year":"2022","unstructured":"Yin F, Huang X, Lin X, Chan TF, Lai KP, Li R (2022) Analyzing the synergistic adverse effects of BPA and its substitute, BHPF, on ulcerative colitis through comparative metabolomics. Chemosphere 287:132160. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132160","journal-title":"Chemosphere"},{"issue":"1","key":"3844_CR241","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3349\/ymj.2018.59.1.4","volume":"59","author":"MY Yoon","year":"2018","unstructured":"Yoon MY, Yoon SS (2018) Disruption of the gut ecosystem by antibiotics. Yonsei Med J 59(1):4\u201312","journal-title":"Yonsei Med J"},{"key":"3844_CR242","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1146\/annurev-pharmtox-011112-140309","volume":"53","author":"K Yoshida","year":"2013","unstructured":"Yoshida K, Maeda K, Sugiyama Y (2013) Hepatic and intestinal drug transporters: prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms. Annu Rev Pharmacol Toxicol 53:581\u2013612. https:\/\/doi.org\/10.1146\/annurev-pharmtox-011112-140309","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"6","key":"3844_CR243","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1053\/j.sempedsurg.2017.10.003","volume":"26","author":"YR Yu","year":"2017","unstructured":"Yu YR, Rodriguez JR (2017) Clinical presentation of Crohn\u2019s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes. Semin Pediatr Surg 26(6):349\u2013355. https:\/\/doi.org\/10.1053\/j.sempedsurg.2017.10.003","journal-title":"Semin Pediatr Surg"},{"issue":"3","key":"3844_CR244","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s11894-013-0315-7","volume":"15","author":"C Zallot","year":"2013","unstructured":"Zallot C, Peyrin-Biroulet L (2013) Deep remission in inflammatory bowel disease: looking beyond symptoms. Curr Gastroenterol Rep 15(3):315. https:\/\/doi.org\/10.1007\/s11894-013-0315-7","journal-title":"Curr Gastroenterol Rep"},{"key":"3844_CR245","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.801892","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Liu F, Xue J, Lee SA, Liu L, Riordan SM (2022) Bacterial species associated with human inflammatory bowel disease and their pathogenic mechanisms. Front Microbiol 13:801892. https:\/\/doi.org\/10.3389\/fmicb.2022.801892","journal-title":"Front Microbiol"},{"key":"3844_CR246","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.chemosphere.2016.03.055","volume":"153","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Zhang Y, Wang G, Han R, Xie X (2016) Effects of chlorpyrifos on the gut microbiome and urine metabolome in mouse (Mus musculus). Chemosphere 153:287\u2013293. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.03.055","journal-title":"Chemosphere"},{"key":"3844_CR247","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.138486","volume":"326","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Liu S, Xu H (2023) Effects of microplastic and engineered nanomaterials on inflammatory bowel disease: a review. Chemosphere 326:138486. https:\/\/doi.org\/10.1016\/j.chemosphere.2023.138486","journal-title":"Chemosphere"},{"key":"3844_CR248","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00276","author":"Y Zhen","year":"2019","unstructured":"Zhen Y, Zhang H (2019) NLRP3 inflammasome and inflammatory bowel disease. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2019.00276","journal-title":"Front Immunol"},{"key":"3844_CR249","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143085","volume":"750","author":"H Zheng","year":"2021","unstructured":"Zheng H, Wang J, Wei X, Chang L, Liu S (2021) Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis. Sci Total Environ 750:143085. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143085","journal-title":"Sci Total Environ"},{"issue":"9","key":"3844_CR250","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/toxics11090730","volume":"11","author":"N Zolotova","year":"2023","unstructured":"Zolotova N, Dzhalilova D, Tsvetkov I, Makarova O (2023) Influence of microplastics on morphological manifestations of experimental acute colitis. Toxics 11(9):730. https:\/\/doi.org\/10.3390\/toxics11090730","journal-title":"Toxics"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03844-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-024-03844-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03844-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T10:07:39Z","timestamp":1729246059000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-024-03844-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":251,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["3844"],"URL":"https:\/\/doi.org\/10.1007\/s00204-024-03844-w","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]},"assertion":[{"value":"4 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"TW, MB, JW, JD, EvdS, and NK declare no conflict of interests. HB is a board member of the Dutch Society of Toxicology, and a member of the Dutch Health Council. MD is the chair of the Dutch research organization Initiate on Crohn\u2019s and Colitis (ICC).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}