{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:30:38Z","timestamp":1766485838300,"version":"3.37.3"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00204-024-03860-w","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T10:02:34Z","timestamp":1725357754000},"page":"4013-4019","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated blood-ethanol concentration promotes reduction of aliphatic ketones (acetone and ethyl methyl ketone) to secondary alcohols along with slower oxidation to aliphatic diols"],"prefix":"10.1007","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-0081","authenticated-orcid":false,"given":"A. W.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"issue":"3","key":"3860_CR1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1520\/JFS12166J","volume":"27","author":"CB Alexander","year":"1982","unstructured":"Alexander CB, McBay AJ, Hudson RP (1982) Isopropanol and isopropanol deaths-ten years\u2019 experience. J Forensic Sci 27(3):541\u2013548","journal-title":"J Forensic Sci"},{"issue":"4","key":"3860_CR2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3109\/15563659009038588","volume":"28","author":"DN Bailey","year":"1990","unstructured":"Bailey DN (1990) Detection of isopropanol in acetonemic patients not exposed to isopropanol. J Toxicol Clin Toxicol 28(4):459\u2013466","journal-title":"J Toxicol Clin Toxicol"},{"issue":"9","key":"3860_CR3","first-page":"1","volume":"18","author":"GA Beauchamp","year":"2016","unstructured":"Beauchamp GA, Valento M (2016) Toxic alcohol ingestion: prompt recognition and management in the emergency department. Emerg Med Pract 18(9):1\u201320","journal-title":"Emerg Med Pract"},{"issue":"2","key":"3860_CR4","first-page":"361","volume":"18","author":"RK Bonnichsen","year":"1948","unstructured":"Bonnichsen RK, Wassen AM (1948) Crystalline alcohol dehydrogenase from horse liver. Arch Biochem 18(2):361\u2013363","journal-title":"Arch Biochem"},{"key":"3860_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1006\/rwfs.2000.0408","volume-title":"Encyclopedia of forensic sciences","author":"W Bonte","year":"2000","unstructured":"Bonte W (2000) Congener analysis. In: Siegel JA, Saukko PJ, Knupfer GC (eds) Encyclopedia of forensic sciences, vol 1. Academic Press, London, pp 93\u2013102"},{"key":"3860_CR6","first-page":"323","volume":"15","author":"W Bonte","year":"1978","unstructured":"Bonte W, Decker J, Busse J (1978) Congener content of high proof alcoholic beverages. Blutalkohol 15:323\u2013338","journal-title":"Blutalkohol"},{"issue":"1","key":"3860_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41387-018-0058-5","volume":"8","author":"F Bovey","year":"2018","unstructured":"Bovey F, Cros J, Tuzson B, Seyssel K, Schneiter P, Emmenegger L, Tappy L (2018) Breath acetone as a marker of energy balance: an exploratory study in healthy humans. Nutr Diabetes 8(1):50. https:\/\/doi.org\/10.1038\/s41387-018-0058-5","journal-title":"Nutr Diabetes"},{"issue":"4","key":"3860_CR8","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0733-8627(20)30246-7","volume":"8","author":"KK Burkhart","year":"1990","unstructured":"Burkhart KK, Kulig KW (1990) The other alcohols: Methanol, ethylene glycol, and isopropanol. Emerg Med Clin North Am 8(4):913\u2013928","journal-title":"Emerg Med Clin North Am"},{"issue":"2","key":"3860_CR9","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S1665-2681(19)32143-X","volume":"2","author":"J Caballeria","year":"2003","unstructured":"Caballeria J (2003) Current concepts in alcohol metabolism. Ann Hepatol 2(2):60\u201368","journal-title":"Ann Hepatol"},{"issue":"4","key":"3860_CR10","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","volume":"16","author":"AI Cederbaum","year":"2012","unstructured":"Cederbaum AI (2012) Alcohol metabolism. Clin Liver Dis 16(4):667\u2013685","journal-title":"Clin Liver Dis"},{"issue":"6","key":"3860_CR11","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1111\/j.1530-0277.1988.tb01347.x","volume":"12","author":"T Ehrig","year":"1988","unstructured":"Ehrig T, Bohren KM, Wermuth B, von Wartburg JP (1988) Degradation of aliphatic alcohols by human liver alcohol dehydrogenase: effect of ethanol and pharmacokinetic implications. Alcohol Clin Exp Res 12(6):789\u2013794","journal-title":"Alcohol Clin Exp Res"},{"key":"3860_CR12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-3-642-96008-6_3","volume-title":"New and upcoming markers of alcohol consumption","author":"T Gilg","year":"2001","unstructured":"Gilg T (2001) Methanol and congeners as markers of alcohol use and abuse. In: Wurst FW (ed) New and upcoming markers of alcohol consumption. Steinkopff Verlag, Darmstadt, pp 35\u201352"},{"issue":"4","key":"3860_CR13","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3390\/ijerph7041285","volume":"7","author":"R Guo","year":"2010","unstructured":"Guo R, Ren J (2010) Alcohol and acetaldehyde in public health: from marvel to menace. Int J Environ Res Public Health 7(4):1285\u20131301","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"3860_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/BF02340834","volume":"105","author":"HT Haffner","year":"1992","unstructured":"Haffner HT, Wehner HD, Scheytt KD, Besserer K (1992) The elimination kinetics of methanol and the influence of ethanol. Int J Legal Med 105(2):111\u2013114","journal-title":"Int J Legal Med"},{"issue":"2","key":"3860_CR15","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0379-0738(96)01901-9","volume":"79","author":"HT Haffner","year":"1996","unstructured":"Haffner HT, Graw M, Besserer K, Blickle U, Henssge C (1996) Endogenous methanol: variability in concentration and rate of production. Evidence of a deep compartment? Forensic Sci Int 79(2):145\u2013154","journal-title":"Forensic Sci Int"},{"issue":"1\u20132","key":"3860_CR16","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0379-0738(97)02119-1","volume":"86","author":"HT Haffner","year":"1997","unstructured":"Haffner HT, Besserer K, Graw M, Voges S (1997) Methanol elimination in non-alcoholics: inter- and intraindividual variation. Forensic Sci Int 86(1\u20132):69\u201376","journal-title":"Forensic Sci Int"},{"issue":"1","key":"3860_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s004140050106","volume":"111","author":"HT Haffner","year":"1998","unstructured":"Haffner HT, Graw M, Besserer K, Stranger J (1998) Curvilinear increase in methanol concentration after inhibition of oxidation by ethanol: significance for the investigation of endogenous methanol concentration and formation. Int J Legal Med 111(1):27\u201331","journal-title":"Int J Legal Med"},{"issue":"1","key":"3860_CR18","first-page":"67","volume":"24","author":"RD Hawkins","year":"1972","unstructured":"Hawkins RD, Kalant H (1972) The metabolism of ethanol and its metabolic effects. Pharmacol Rev 24(1):67\u2013157","journal-title":"Pharmacol Rev"},{"issue":"3","key":"3860_CR19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1600-0773.1987.tb01737.x","volume":"60","author":"AW Jones","year":"1987","unstructured":"Jones AW (1987) Elimination half-life of methanol during hangover. Pharmacol Toxicol 60(3):217\u2013220","journal-title":"Pharmacol Toxicol"},{"issue":"8774","key":"3860_CR20","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/0140-6736(91)91956-U","volume":"338","author":"AW Jones","year":"1991","unstructured":"Jones AW (1991) 2,3-butanediol in blood from drinking technical alcohol containing 2-butanone. Lancet 338(8774):1090","journal-title":"Lancet"},{"issue":"1","key":"3860_CR21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/jat\/24.1.8","volume":"24","author":"AW Jones","year":"2000","unstructured":"Jones AW (2000) Elimination half-life of acetone in humans: case reports and review of the literature. J Anal Toxicol 24(1):8\u201310","journal-title":"J Anal Toxicol"},{"issue":"2","key":"3860_CR22","first-page":"117","volume":"33","author":"AW Jones","year":"2021","unstructured":"Jones AW (2021) Clinical and forensic toxicology of methanol. Forensic Sci Rev 33(2):117\u2013143","journal-title":"Forensic Sci Rev"},{"key":"3860_CR23","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1002\/9781119648628.ch52","volume-title":"Handbook of forensic medicine","author":"AW Jones","year":"2022","unstructured":"Jones AW (2022) Aliphatic alcohols. In: Madea B (ed) Handbook of forensic medicine, 2nd edn. John Wiley & Sons, London, pp 1167\u20131196","edition":"2"},{"issue":"5","key":"3860_CR24","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1520\/JFS12748J","volume":"34","author":"AW Jones","year":"1989","unstructured":"Jones AW, Schuberth J (1989) Computer-aided headspace gas chromatography applied to blood-alcohol analysis: importance of online process control. J Forensic Sci 34(5):1116\u20131127","journal-title":"J Forensic Sci"},{"issue":"4","key":"3860_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/jat\/13.4.199","volume":"13","author":"AW Jones","year":"1989","unstructured":"Jones AW, Lund M, Andersson E (1989) Drinking drivers in Sweden who consume denatured alcohol preparations: an analytical-toxicological study. J Anal Toxicol 13(4):199\u2013203","journal-title":"J Anal Toxicol"},{"issue":"8","key":"3860_CR26","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/clinchem\/37.8.1453","volume":"37","author":"AW Jones","year":"1991","unstructured":"Jones AW, Nilsson L, Gladh SA, Karlsson K, Beck-Friis J (1991) 2,3-Butanediol in plasma from an alcoholic mistakenly identified as ethylene glycol by gas-chromatographic analysis. Clin Chem 37(8):1453\u20131455","journal-title":"Clin Chem"},{"issue":"3","key":"3860_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/jat\/17.3.182","volume":"17","author":"AW Jones","year":"1993","unstructured":"Jones AW, Sagarduy A, Ericsson E, Arnqvist HJ (1993) Concentrations of acetone in venous blood samples from drunk drivers, type-I diabetic outpatients, and healthy blood donors. J Anal Toxicol 17(3):182\u2013185","journal-title":"J Anal Toxicol"},{"issue":"4","key":"3860_CR28","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1520\/JFS13851J","volume":"40","author":"AW Jones","year":"1995","unstructured":"Jones AW, Andersson L (1995) Biotransformation of acetone to isopropanol observed in a motorist involved in a sobriety check. J Forensic Sci 40(4):686\u2013687","journal-title":"J Forensic Sci"},{"issue":"2","key":"3860_CR29","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0304-4165(03)00051-5","volume":"1621","author":"MP Kalapos","year":"2003","unstructured":"Kalapos MP (2003) On the mammalian acetone metabolism: from chemistry to clinical implications. Biochim Biophys Acta 1621(2):122\u2013139","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"3860_CR30","doi-asserted-by":"publisher","first-page":"208","DOI":"10.2215\/CJN.03220807","volume":"3","author":"JA Kraut","year":"2008","unstructured":"Kraut JA, Kurtz I (2008) Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol 3(1):208\u2013225","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"3860_CR31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1056\/NEJMra1615295","volume":"378","author":"JA Kraut","year":"2018","unstructured":"Kraut JA, Mullins ME (2018) Toxic alcohols. N Engl J Med 378(3):270\u2013280","journal-title":"N Engl J Med"},{"issue":"1","key":"3860_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0016-5085(66)80107-5","volume":"50","author":"CS Lieber","year":"1966","unstructured":"Lieber CS (1966) Hepatic and metabolic effects of alcohol. Gastroenterology 50(1):119\u2013133","journal-title":"Gastroenterology"},{"issue":"1","key":"3860_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cld.2004.10.005","volume":"9","author":"CS Lieber","year":"2005","unstructured":"Lieber CS (2005) Metabolism of alcohol. Clin Liver Dis 9(1):1\u201335","journal-title":"Clin Liver Dis"},{"issue":"1","key":"3860_CR34","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/0003-9861(70)90009-3","volume":"140","author":"JC Mani","year":"1970","unstructured":"Mani JC, Pietruszko R, Theorell H (1970) Methanol activity of alcohol dehydrogenases from human liver, horse liver, and yeast. Arch Biochem Biophys 140(1):52\u201359","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"3860_CR35","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/bcp.12824","volume":"81","author":"K McMartin","year":"2016","unstructured":"McMartin K, Jacobsen D, Hovda KE (2016) Antidotes for poisoning by alcohols that form toxic metabolites. Br J Clin Pharmacol 81(3):505\u2013515","journal-title":"Br J Clin Pharmacol"},{"issue":"2","key":"3860_CR36","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3109\/15563659509000464","volume":"33","author":"MS Monaghan","year":"1995","unstructured":"Monaghan MS, Olsen KM, Ackerman BH, Fuller GL, Porter WH, Pappas AA (1995) Measurement of serum isopropanol and the acetone metabolite by proton nuclear magnetic resonance: application to pharmacokinetic evaluation in a simulated overdose model. J Toxicol Clin Toxicol 33(2):141\u2013149","journal-title":"J Toxicol Clin Toxicol"},{"issue":"2","key":"3860_CR37","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/clinchem\/31.2.326","volume":"31","author":"M Natowicz","year":"1985","unstructured":"Natowicz M, Donahue J, Gorman L, Kane M, McKissick J, Shaw L (1985) Pharmacokinetic analysis of a case of isopropanol intoxication. Clin Chem 31(2):326\u2013328","journal-title":"Clin Chem"},{"issue":"4","key":"3860_CR38","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.metabol.2015.12.007","volume":"65","author":"EA Nyenwe","year":"2016","unstructured":"Nyenwe EA, Kitabchi AE (2016) The evolution of diabetic ketoacidosis: an update of its etiology, pathogenesis and management. Metabolism 65(4):507\u2013521","journal-title":"Metabolism"},{"issue":"6","key":"3860_CR39","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2337\/diab.35.6.668","volume":"35","author":"GA Reichard Jr","year":"1986","unstructured":"Reichard GA Jr, Skutches CL, Hoeldtke RD, Owen OE (1986) Acetone metabolism in humans during diabetic ketoacidosis. Diabetes 35(6):668\u2013674","journal-title":"Diabetes"},{"key":"3860_CR40","doi-asserted-by":"publisher","first-page":"024002","DOI":"10.1088\/1752-7163\/aa66d3","volume":"11","author":"V Ruzs\u00e1nyil","year":"2017","unstructured":"Ruzs\u00e1nyil V, Kalapos MP (2017) Breath acetone as a potential marker in clinical practice. J Breath Res 11:024002","journal-title":"J Breath Res"},{"issue":"3","key":"3860_CR41","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1080\/02791072.2017.1290302","volume":"49","author":"A Sharma","year":"2017","unstructured":"Sharma A, Morrow JD (2017) Isopropyl alcohol swabs as a preferred substance of abuse. J Psychoactive Drugs 49(3):258\u2013261","journal-title":"J Psychoactive Drugs"},{"issue":"5","key":"3860_CR42","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3109\/15563650.2014.914527","volume":"52","author":"RJ Slaughter","year":"2014","unstructured":"Slaughter RJ, Mason RW, Beasley DM, Vale JA, Schep LJ (2014) Isopropanol poisoning. Clin Toxicol (Phila) 52(5):470\u2013478","journal-title":"Clin Toxicol (Phila)"},{"issue":"8","key":"3860_CR43","doi-asserted-by":"publisher","first-page":"N23","DOI":"10.1088\/0967-3334\/32\/8\/N01","volume":"32","author":"P Spanel","year":"2011","unstructured":"Spanel P, Dryahina K, Rejskova A, Chippendale TW, Smith D (2011) Breath acetone concentration; biological variability and the influence of diet. Physiol Meas 32(8):N23-31","journal-title":"Physiol Meas"},{"key":"3860_CR44","first-page":"31","volume":"20","author":"H Theorell","year":"1958","unstructured":"Theorell H (1958) Kinetics and equilibria in the liver alcohol dehydrogenase system. Adv Enzymol Relat Subj Biochem 20:31\u201349","journal-title":"Adv Enzymol Relat Subj Biochem"},{"key":"3860_CR45","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3891\/acta.chem.scand.05-1105","volume":"5","author":"H Theorell","year":"1951","unstructured":"Theorell H, Bonnichsen R (1951) Studies on liver alcohol dehydrogenase. 1. Equilibria and initial reaction velocities. Acta Chem Scand 5:1105\u20131126","journal-title":"Acta Chem Scand"},{"issue":"7","key":"3860_CR46","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/anatox\/35.7.501","volume":"35","author":"NB Tiscione","year":"2011","unstructured":"Tiscione NB, Alford I, Yeatman DT, Shan X (2011) Ethanol analysis by headspace gas chromatography with simultaneous flame-ionization and mass spectrometry detection. J Anal Toxicol 35(7):501\u2013511","journal-title":"J Anal Toxicol"},{"issue":"3","key":"3860_CR47","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/ajcp\/93.3.357","volume":"93","author":"MT Watts","year":"1990","unstructured":"Watts MT, McDonald OL (1990) The effect of sodium chloride concentration, water content, and protein on the gas chromatographic headspace analysis of ethanol in plasma. Am J Clin Pathol 93(3):357\u2013362","journal-title":"Am J Clin Pathol"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03860-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-024-03860-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03860-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:03:41Z","timestamp":1729602221000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-024-03860-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["3860"],"URL":"https:\/\/doi.org\/10.1007\/s00204-024-03860-w","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"type":"print","value":"0340-5761"},{"type":"electronic","value":"1432-0738"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"17 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author does not consider that there are any conflicts of interest to declare in relation to this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective study made use of a forensic toxicology database and the selected cases were unidentified, and therefore, no formal ethical approval was deemed necessary.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}