{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:45:50Z","timestamp":1780339550552,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan","award":["25670313"],"award-info":[{"award-number":["25670313"]}]},{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan","award":["15H04784"],"award-info":[{"award-number":["15H04784"]}]},{"DOI":"10.13039\/501100005611","name":"University of Fukui","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005611","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Indium compounds are used in manufacturing displays of mobile phones and televisions. These compounds cause interstitial pneumonia in workers and lung cancer in animals, but their precise mechanisms are unclear. In this study, we performed microarray analysis of gene expression in lung tissues of indium-exposed rats. Male Wistar rats (8-week-old) were exposed to indium oxide (In<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>, mean particle diameter 0.14\u00a0\u03bcm) and indium-tin oxide (ITO, mean particle diameter 0.95\u00a0\u03bcm) by intratracheal instillation (10\u00a0mg indium\/kg body weight\/instillation) twice a week and five times in total. These rats were sacrificed immediately, 3\u00a0weeks and 12\u00a0weeks after the last instillation. Hematoxylin and eosin and Masson\u2019s trichrome staining showed that indium compounds induced infiltration of neutrophils and macrophages into alveolar space, and fibrosis around bronchial epithelium and in alveolar wall. Microarray analysis revealed that In<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> and ITO significantly upregulated 233 and 676 genes at 12\u00a0weeks, respectively (&gt;\u2009twofold, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 by ANOVA\u2009+\u2009Tukey\u2019s test). In<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> and ITO largely upregulated <jats:italic>Lcn2<\/jats:italic> (lipocalin-2) (49.4- and 91.8-fold), <jats:italic>S100a9<\/jats:italic> (30.2- and 46.5-fold) and <jats:italic>S100a8<\/jats:italic> (11.5- and 22.0-fold), respectively. Metascape database predicted that these genes participate in immunomodulatory and inflammatory responses. Real-time PCR confirmed that these genes were upregulated by indium compounds throughout the experiments. In Western blotting, S100A9 expression was significantly increased by indium exposure, whereas LCN2 expression was only slightly increased. Fluorescent immunohistochemistry revealed that S100A9 and S100A8 were expressed in alveolar epithelial cells and neutrophils in indium-exposed rats. These results suggest that S100 proteins contribute to indium-induced lung diseases via neutrophil-mediated inflammatory responses.<\/jats:p>","DOI":"10.1007\/s00204-024-03897-x","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T17:17:00Z","timestamp":1731086220000},"page":"245-258","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microarray analysis of gene expression in lung tissues of indium-exposed rats: possible roles of S100 proteins in lung diseases"],"prefix":"10.1007","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-1498","authenticated-orcid":false,"given":"Yusuke","family":"Hiraku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyo","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharif","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"issue":"2","key":"3897_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1539\/joh.17-0146-OA","volume":"60","author":"T Afroz","year":"2018","unstructured":"Afroz T, Hiraku Y, Ma N, Ahmed S, Oikawa S, Kawanishi S, Murata M (2018) Nitrative DNA damage in cultured macrophages exposed to indium oxide. J Occup Health 60(2):148\u2013155. https:\/\/doi.org\/10.1539\/joh.17-0146-OA","journal-title":"J Occup Health"},{"key":"3897_CR2","doi-asserted-by":"publisher","first-page":"10741","DOI":"10.1038\/s41598-020-67488-3","volume":"10","author":"S Ahmed","year":"2020","unstructured":"Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y (2020) Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions. Sci Rep 10:10741. https:\/\/doi.org\/10.1038\/s41598-020-67488-3","journal-title":"Sci Rep"},{"issue":"1","key":"3897_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/ajim.22402","volume":"58","author":"S Choi","year":"2015","unstructured":"Choi S, Won YL, Kim D, Lee MY, Choi YJ, Park JS, Kim HR, Jung JI, Lee SG, Kim EA (2015) Interstitial lung disorders in the indium workers of Korea: an update study for the relationship with biological exposure indices. Am J Ind Med 58(1):61\u201368. https:\/\/doi.org\/10.1002\/ajim.22402","journal-title":"Am J Ind Med"},{"issue":"2","key":"3897_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1183\/09031936.00020306","volume":"29","author":"T Chonan","year":"2007","unstructured":"Chonan T, Taguchi O, Omae K (2007) Interstitial pulmonary disorders in indium-processing workers. Eur Respir J 29(2):317\u2013324. https:\/\/doi.org\/10.1183\/09031936.00020306","journal-title":"Eur Respir J"},{"issue":"5","key":"3897_CR5","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1164\/rccm.200907-1022CR","volume":"181","author":"KJ Cummings","year":"2010","unstructured":"Cummings KJ, Donat WE, Ettensohn DB, Roggli VL, Ingram P, Kreiss K (2010) Pulmonary alveolar proteinosis in workers at an indium processing facility. Am J Respir Crit Care Med 181(5):458\u2013464. https:\/\/doi.org\/10.1164\/rccm.200907-1022CR","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"3897_CR6","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1378\/chest.11-1880","volume":"141","author":"KJ Cummings","year":"2012","unstructured":"Cummings KJ, Nakano M, Omae K, Takeuchi K, Chonan T, Xiao YL, Harley RA, Roggli VL, Hebisawa A, Tallaksen RJ, Trapnell BC, Day GA, Saito R, Stanton ML, Suarthana E, Kreiss K (2012) Indium lung disease. Chest 141(6):1512\u20131521. https:\/\/doi.org\/10.1378\/chest.11-1880","journal-title":"Chest"},{"issue":"6","key":"3897_CR7","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1189\/jlb.0607397","volume":"83","author":"S Ghavami","year":"2008","unstructured":"Ghavami S, Rashedi I, Dattilo BM, Eshraghi M, Chazin WJ, Hashemi M, Wesselborg S, Kerkhoff C, Los M (2008) S100A8\/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. J Leukoc Biol 83(6):1484\u20131492. https:\/\/doi.org\/10.1189\/jlb.0607397","journal-title":"J Leukoc Biol"},{"issue":"4","key":"3897_CR8","doi-asserted-by":"publisher","first-page":"L726","DOI":"10.1152\/ajplung.00080.2021","volume":"321","author":"S Guardado","year":"2021","unstructured":"Guardado S, Ojeda-Juarez D, Kaul M, Nordgren TM (2021) Comprehensive review of lipocalin 2-mediated effects in lung inflammation. Am J Physiol Lung Cell Mol Physiol 321(4):L726\u2013L733. https:\/\/doi.org\/10.1152\/ajplung.00080.2021","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"3897_CR9","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.taap.2012.02.010","volume":"260","author":"F Guo","year":"2012","unstructured":"Guo F, Ma N, Horibe Y, Kawanishi S, Murata M, Hiraku Y (2012) Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells. Toxicol Appl Pharmacol 260(2):183\u2013192. https:\/\/doi.org\/10.1016\/j.taap.2012.02.010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"3897_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12989-016-0127-7","volume":"13","author":"Y Hiraku","year":"2016","unstructured":"Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M (2016) Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation. Part Fibre Toxicol 13(1):16. https:\/\/doi.org\/10.1186\/s12989-016-0127-7","journal-title":"Part Fibre Toxicol"},{"key":"3897_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mrgentox.2017.04.002","volume":"818","author":"Y Hiraku","year":"2017","unstructured":"Hiraku Y, Nishikawa Y, Ma N, Afroz T, Mizobuchi K, Ishiyama R, Matsunaga Y, Ichinose T, Kawanishi S, Murata M (2017) Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells. Mutat Res 818:7\u201316. https:\/\/doi.org\/10.1016\/j.mrgentox.2017.04.002","journal-title":"Mutat Res"},{"issue":"3","key":"3897_CR12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1539\/joh.13-0231-oa","volume":"56","author":"Y Hiraku","year":"2014","unstructured":"Hiraku Y, Sakai K, Shibata E, Kamijima M, Hisanaga N, Ma N, Kawanishi S, Murata M (2014) Formation of the nitrative DNA lesion 8-nitroguanine is associated with asbestos contents in human lung tissues: a pilot study. J Occup Health 56(3):186\u2013196. https:\/\/doi.org\/10.1539\/joh.13-0231-oa","journal-title":"J Occup Health"},{"issue":"1","key":"3897_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/1348-9585.12282","volume":"63","author":"Y Hiraku","year":"2021","unstructured":"Hiraku Y, Watanabe J, Kaneko A, Ichinose T, Murata M (2021) MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck. J Occup Health 63(1):e12282. https:\/\/doi.org\/10.1002\/1348-9585.12282","journal-title":"J Occup Health"},{"issue":"3","key":"3897_CR14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1539\/joh.45.137","volume":"45","author":"T Homma","year":"2003","unstructured":"Homma T, Ueno T, Sekizawa K, Tanaka A, Hirata M (2003) Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide. J Occup Health 45(3):137\u2013139. https:\/\/doi.org\/10.1539\/joh.45.137","journal-title":"J Occup Health"},{"issue":"7","key":"3897_CR15","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/1759-7714.12649","volume":"9","author":"H Huang","year":"2018","unstructured":"Huang H, Huang Q, Tang T, Gu L, Du J, Li Z, Lu X, Zhou X (2018) Clinical significance of calcium-binding protein S100A8 and S100A9 expression in non-small cell lung cancer. Thorac Cancer 9(7):800\u2013804. https:\/\/doi.org\/10.1111\/1759-7714.12649","journal-title":"Thorac Cancer"},{"issue":"4","key":"3897_CR16","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00408-020-00376-9","volume":"198","author":"SJ Huang","year":"2020","unstructured":"Huang SJ, Ding ZN, Xiang HX, Fu L, Fei J (2020) Association between serum S100A8\/S100A9 heterodimer and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease. Lung 198(4):645\u2013652. https:\/\/doi.org\/10.1007\/s00408-020-00376-9","journal-title":"Lung"},{"key":"3897_CR17","unstructured":"IARC (2006) Indium phosphide. IARC Monographs on the Evaluation of Carcinogic Risks to Humans, vol 86. Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide, p 197\u2013224"},{"key":"3897_CR18","unstructured":"IARC (2018) Indium tin oxide. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 118. Welding, Molybdenum Trioxide, and Indium Tin Oxide, p 283\u2013306"},{"issue":"8","key":"3897_CR19","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/rcm.6866","volume":"28","author":"YM Juang","year":"2014","unstructured":"Juang YM, Lai BH, Chien HJ, Ho M, Cheng TJ, Lai CC (2014) Changes in protein expression in rat bronchoalveolar lavage fluid after exposure to zinc oxide nanoparticles: an iTRAQ proteomic approach. Rapid Commun Mass Spectrom 28(8):974\u2013980. https:\/\/doi.org\/10.1002\/rcm.6866","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"4","key":"3897_CR20","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.3390\/ijms22041706","volume":"22","author":"OS Kotsiou","year":"2021","unstructured":"Kotsiou OS, Papagiannis D, Papadopoulou R, Gourgoulianis KI (2021) Calprotectin in lung diseases. Int J Mol Sci 22(4):1706. https:\/\/doi.org\/10.3390\/ijms22041706","journal-title":"Int J Mol Sci"},{"key":"3897_CR21","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cytogfr.2021.10.004","volume":"63","author":"L Mellett","year":"2022","unstructured":"Mellett L, Khader SA (2022) S100A8\/A9 in COVID-19 pathogenesis: impact on clinical outcomes. Cytokine Growth Factor Rev 63:90\u201397. https:\/\/doi.org\/10.1016\/j.cytogfr.2021.10.004","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"3897_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1539\/joh.10-0057-oa","volume":"53","author":"K Nagano","year":"2011","unstructured":"Nagano K, Nishizawa T, Umeda Y, Kasai T, Noguchi T, Gotoh K, Ikawa N, Eitaki Y, Kawasumi Y, Yamauchi T, Arito H, Fukushima S (2011) Inhalation carcinogenicity and chronic toxicity of indium-tin oxide in rats and mice. J Occup Health 53(3):175\u2013187. https:\/\/doi.org\/10.1539\/joh.10-0057-oa","journal-title":"J Occup Health"},{"issue":"3","key":"3897_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/1348-9585.12050","volume":"61","author":"M Nakano","year":"2019","unstructured":"Nakano M, Omae K, Tanaka A, Hirata M (2019) Possibility of lung cancer risk in indium-exposed workers: an 11-year multicenter cohort study. J Occup Health 61(3):251\u2013256. https:\/\/doi.org\/10.1002\/1348-9585.12050","journal-title":"J Occup Health"},{"issue":"5","key":"3897_CR24","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1378\/chest.13-2484","volume":"146","author":"M Nakano","year":"2014","unstructured":"Nakano M, Omae K, Uchida K, Michikawa T, Yoshioka N, Hirata M, Tanaka A (2014) Five-year cohort study: emphysematous progression of indium-exposed workers. Chest 146(5):1166\u20131175. https:\/\/doi.org\/10.1378\/chest.13-2484","journal-title":"Chest"},{"key":"3897_CR25","unstructured":"National Toxicology Program (2001) Toxicology and carcinogenesis studies of indium phosphide (CAS No. 22398-90-7) in F344\/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser(499):7\u2013340."},{"issue":"5","key":"3897_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00420-010-0575-6","volume":"84","author":"K Omae","year":"2011","unstructured":"Omae K, Nakano M, Tanaka A, Hirata M, Hamaguchi T, Chonan T (2011) Indium lung-case reports and epidemiology. Int Arch Occup Environ Health 84(5):471\u2013477. https:\/\/doi.org\/10.1007\/s00420-010-0575-6","journal-title":"Int Arch Occup Environ Health"},{"issue":"6","key":"3897_CR27","doi-asserted-by":"publisher","first-page":"L1021","DOI":"10.1152\/ajplung.00207.2020","volume":"319","author":"C Railwah","year":"2020","unstructured":"Railwah C, Lora A, Zahid K, Goldenberg H, Campos M, Wyman A, Jundi B, Ploszaj M, Rivas M, Dabo A, Majka SM, Foronjy R, El Gazzar M, Geraghty P (2020) Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 319(6):L1021\u2013L1035. https:\/\/doi.org\/10.1152\/ajplung.00207.2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"3897_CR28","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.4049\/jimmunol.170.6.3233","volume":"170","author":"C Ryckman","year":"2003","unstructured":"Ryckman C, Vandal K, Rouleau P, Talbot M, Tessier PA (2003) Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8\/A9 induce neutrophil chemotaxis and adhesion. J Immunol 170(6):3233\u20133242. https:\/\/doi.org\/10.4049\/jimmunol.170.6.3233","journal-title":"J Immunol"},{"key":"3897_CR29","doi-asserted-by":"publisher","first-page":"5488591","DOI":"10.1155\/2021\/5488591","volume":"2021","author":"Z Sattar","year":"2021","unstructured":"Sattar Z, Lora A, Jundi B, Railwah C, Geraghty P (2021) The S100 protein family as players and therapeutic targets in pulmonary diseases. Pulm Med 2021:5488591. https:\/\/doi.org\/10.1155\/2021\/5488591","journal-title":"Pulm Med"},{"issue":"1","key":"3897_CR30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/JLB.3COVCRA0720-359R","volume":"109","author":"H Shi","year":"2021","unstructured":"Shi H, Zuo Y, Yalavarthi S, Gockman K, Zuo M, Madison JA, Blair C, Woodward W, Lezak SP, Lugogo NL, Woods RJ, Lood C, Knight JS, Kanthi Y (2021) Neutrophil calprotectin identifies severe pulmonary disease in COVID-19. J Leukoc Biol 109(1):67\u201372. https:\/\/doi.org\/10.1002\/JLB.3COVCRA0720-359R","journal-title":"J Leukoc Biol"},{"issue":"1","key":"3897_CR31","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1539\/joh.l9097","volume":"52","author":"A Tanaka","year":"2010","unstructured":"Tanaka A, Hirata M, Homma T, Kiyohara Y (2010) Chronic pulmonary toxicity study of indium-tin oxide and indium oxide following intratracheal instillations into the lungs of hamsters. J Occup Health 52(1):14\u201322. https:\/\/doi.org\/10.1539\/joh.l9097","journal-title":"J Occup Health"},{"issue":"6","key":"3897_CR32","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.resinv.2021.05.008","volume":"59","author":"K Tanaka","year":"2021","unstructured":"Tanaka K, Enomoto N, Hozumi H, Isayama T, Naoi H, Aono Y, Katsumata M, Yasui H, Karayama M, Suzuki Y, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T (2021) Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis. Respir Investig 59(6):827\u2013836. https:\/\/doi.org\/10.1016\/j.resinv.2021.05.008","journal-title":"Respir Investig"},{"key":"3897_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/296149","volume":"2015","author":"MR Tardif","year":"2015","unstructured":"Tardif MR, Chapeton-Montes JA, Posvandzic A, Page N, Gilbert C, Tessier PA (2015) Secretion of S100A8, S100A9, and S100A12 by neutrophils involves reactive oxygen species and potassium efflux. J Immunol Res 2015:296149. https:\/\/doi.org\/10.1155\/2015\/296149","journal-title":"J Immunol Res"},{"issue":"1","key":"3897_CR34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/toxsci\/kfq363","volume":"120","author":"JG Teeguarden","year":"2011","unstructured":"Teeguarden JG, Webb-Robertson BJ, Waters KM, Murray AR, Kisin ER, Varnum SM, Jacobs JM, Pounds JG, Zanger RC, Shvedova AA (2011) Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice. Toxicol Sci 120(1):123\u2013135. https:\/\/doi.org\/10.1093\/toxsci\/kfq363","journal-title":"Toxicol Sci"},{"key":"3897_CR35","unstructured":"U.S. Geological Survey (2023) Indium. Mineral Commodity Summaries 2023. U.S. Geological Publishing Office, St. Louis, USA, p 88\u201389"},{"issue":"9","key":"3897_CR36","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/nm1638","volume":"13","author":"T Vogl","year":"2007","unstructured":"Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J (2007) Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nature Med 13(9):1042\u20131049. https:\/\/doi.org\/10.1038\/nm1638","journal-title":"Nature Med"},{"issue":"3","key":"3897_CR37","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/cei.12139","volume":"173","author":"X Xu","year":"2013","unstructured":"Xu X, Chen H, Zhu X, Ma Y, Liu Q, Xue Y, Chu H, Wu W, Wang J, Zou H (2013) S100A9 promotes human lung fibroblast cells activation through receptor for advanced glycation end-product-mediated extracellular-regulated kinase 1\/2, mitogen-activated protein-kinase and nuclear factor-\u03baB-dependent pathways. Clin Exp Immunol 173(3):523\u2013535. https:\/\/doi.org\/10.1111\/cei.12139","journal-title":"Clin Exp Immunol"},{"key":"3897_CR38","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1465-9921-11-70","volume":"11","author":"PC Zeidler-Erdely","year":"2010","unstructured":"Zeidler-Erdely PC, Kashon ML, Li S, Antonini JM (2010) Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A\/J and C57BL\/6J mice. Respir Res 11:70. https:\/\/doi.org\/10.1186\/1465-9921-11-70","journal-title":"Respir Res"},{"issue":"1","key":"3897_CR39","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10(1):1523. https:\/\/doi.org\/10.1038\/s41467-019-09234-6","journal-title":"Nat Commun"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03897-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-024-03897-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03897-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T17:27:32Z","timestamp":1737134852000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-024-03897-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3897"],"URL":"https:\/\/doi.org\/10.1007\/s00204-024-03897-x","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"1 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. The authors have no conflict of interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}