{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:15:58Z","timestamp":1786979758768,"version":"build-2736575974"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100011229","name":"State Key Laboratory of Integrated Pest Management","doi-asserted-by":"publisher","award":["No. IPM2112"],"award-info":[{"award-number":["No. IPM2112"]}],"id":[{"id":"10.13039\/501100011229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31970416"],"award-info":[{"award-number":["No. 31970416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00204-024-03934-9","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T02:10:16Z","timestamp":1734919816000},"page":"1237-1252","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Involvement of gut microbiota in chlorpyrifos-induced subchronic toxicity in mice"],"prefix":"10.1007","volume":"99","author":[{"given":"Xiaohua","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-2886","authenticated-orcid":false,"given":"Yi-Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"3934_CR1","doi-asserted-by":"publisher","first-page":"115122","DOI":"10.1016\/j.ecoenv.2023.115122","volume":"262","author":"AB Abdel-Naim","year":"2023","unstructured":"Abdel-Naim AB, Hassanein EHM, Binmahfouz LS, Bagher AM, Hareeri RH, Algandaby MM, Fadladdin YAJ, Aleya L, Abdel-Daim MM (2023) Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2\/HO-1 axis. Ecotoxicol Environ Saf 262:115122. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115122","journal-title":"Ecotoxicol Environ Saf"},{"key":"3934_CR2","doi-asserted-by":"publisher","first-page":"121281","DOI":"10.1016\/j.lfs.2022.121281","volume":"313","author":"MS Abduh","year":"2023","unstructured":"Abduh MS, Alruhaimi RS, Alqhtani HA, Hussein OE, Abukhalil MH, Kamel EM, Mahmoud AM (2023) Rosmarinic acid mitigates chlorpyrifos-induced oxidative stress, inflammation, and kidney injury in rats by modulating SIRT1 and Nrf2\/HO-1 signaling. Life Sci 313:121281. https:\/\/doi.org\/10.1016\/j.lfs.2022.121281","journal-title":"Life Sci"},{"issue":"7","key":"3934_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3390\/biom9070261","volume":"9","author":"G Albasher","year":"2019","unstructured":"Albasher G, Almeer R, Al-Otibi FO, Al-Kubaisi N, Mahmoud AM (2019) Ameliorative effect of beta vulgaris root extract on chlorpyrifos-induced oxidative stress, inflammation and liver injury in rats. Biomolecules 9(7):261. https:\/\/doi.org\/10.3390\/biom9070261","journal-title":"Biomolecules"},{"issue":"11","key":"3934_CR4","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.3390\/nu15112610","volume":"15","author":"GH Baek","year":"2023","unstructured":"Baek GH, Yoo KM, Kim S-Y, Lee DH, Chung H, Jung S-C, Park S-K, Kim J-S (2023) Collagen peptide exerts an anti-obesity effect by influencing the firmicutes\/bacteroidetes ratio in the gut. Nutrients 15(11):2610. https:\/\/doi.org\/10.3390\/nu15112610","journal-title":"Nutrients"},{"key":"3934_CR5","doi-asserted-by":"publisher","first-page":"7489","DOI":"10.1038\/ncomms8489","volume":"6","author":"C-J Chang","year":"2015","unstructured":"Chang C-J, Lin C-S, Lu C-C, Martel J, Ko Y-F, Ojcius DM, Tseng S-F, Wu T-R, Chen Y-YM, Young JD, Lai H-C (2015) Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun 6:7489. https:\/\/doi.org\/10.1038\/ncomms8489","journal-title":"Nat Commun"},{"key":"3934_CR6","doi-asserted-by":"publisher","first-page":"688780","DOI":"10.3389\/fphys.2021.688780","volume":"12","author":"T Chen","year":"2021","unstructured":"Chen T, Li R, Chen P (2021) Gut microbiota and chemical-induced acute liver injury. Front Physiol 12:688780. https:\/\/doi.org\/10.3389\/fphys.2021.688780","journal-title":"Front Physiol"},{"issue":"11","key":"3934_CR7","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1016\/j.chom.2021.09.009","volume":"29","author":"O Chipashvili","year":"2021","unstructured":"Chipashvili O, Utter DR, Bedree JK, Ma Y, Schulte F, Mascarin G, Alayyoubi Y, Chouhan D, Hardt M, Bidlack F, Hasturk H, He X, McLean JS, Bor B (2021) Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation. Cell Host Microbe 29(11):1649-1662.e7. https:\/\/doi.org\/10.1016\/j.chom.2021.09.009","journal-title":"Cell Host Microbe"},{"issue":"2","key":"3934_CR8","doi-asserted-by":"publisher","first-page":"423","DOI":"10.47162\/RJME.61.2.11","volume":"61","author":"C Cobilinschi","year":"2020","unstructured":"Cobilinschi C, \u0162incu RC, Cobilinschi CO, Neagu TP, Becheanu G, Sinescu RD, Checheri\u0163\u0103 IA, Grin\u0163escu IM, Lasc\u0103r I (2020) Histopathological features of low-dose organophosphate exposure. Rom J Morphol Embryol 61(2):423\u2013432. https:\/\/doi.org\/10.47162\/RJME.61.2.11","journal-title":"Rom J Morphol Embryol"},{"key":"3934_CR9","doi-asserted-by":"publisher","first-page":"113068","DOI":"10.1016\/j.fct.2022.113068","volume":"164","author":"M Coremen","year":"2022","unstructured":"Coremen M, Turkyilmaz IB, Us H, Us AS, Celik S, Ozel AE, Bulan OK, Yanardag R (2022) Lupeol inhibits pesticides induced hepatotoxicity via reducing oxidative stress and inflammatory markers in rats. Food Chem Toxicol 164:113068. https:\/\/doi.org\/10.1016\/j.fct.2022.113068","journal-title":"Food Chem Toxicol"},{"key":"3934_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.scitotenv.2015.11.162","volume":"544","author":"Y Deng","year":"2016","unstructured":"Deng Y, Zhang Y, Lu Y, Zhao Y, Ren H (2016) Hepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice. Sci Total Environ 544:507\u2013514. https:\/\/doi.org\/10.1016\/j.scitotenv.2015.11.162","journal-title":"Sci Total Environ"},{"issue":"2","key":"3934_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408440802272158","volume":"38","author":"DL Eaton","year":"2008","unstructured":"Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS (2008) Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol 38(2):1\u2013125. https:\/\/doi.org\/10.1080\/10408440802272158","journal-title":"Crit Rev Toxicol"},{"issue":"3","key":"3934_CR12","doi-asserted-by":"publisher","first-page":"e01087","DOI":"10.1128\/mBio.01087-19","volume":"10","author":"MA Engevik","year":"2019","unstructured":"Engevik MA, Luk B, Chang-Graham AL, Hall A, Herrmann B, Ruan W, Endres BT, Shi Z, Garey KW, Hyser JM, Versalovic J (2019) Bifidobacterium dentium fortifies the intestinal mucus layer via autophagy and calcium signaling pathways. eBio 10(3):e01087-19. https:\/\/doi.org\/10.1128\/mBio.01087-19","journal-title":"eBio"},{"key":"3934_CR13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-4614-1463-6_3","volume":"215","author":"SY Gebremariam","year":"2012","unstructured":"Gebremariam SY, Beutel MW, Yonge DR, Flury M, Harsh JB (2012) Adsorption and desorption of chlorpyrifos to soils and sediments. Rev Environ Contam Toxicol 215:123\u2013175. https:\/\/doi.org\/10.1007\/978-1-4614-1463-6_3","journal-title":"Rev Environ Contam Toxicol"},{"issue":"1","key":"3934_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jhep.2018.02.024","volume":"69","author":"S Gong","year":"2018","unstructured":"Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y, Kaplowitz N, Chen P (2018) Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol 69(1):51\u201359. https:\/\/doi.org\/10.1016\/j.jhep.2018.02.024","journal-title":"J Hepatol"},{"key":"3934_CR15","doi-asserted-by":"publisher","first-page":"114938","DOI":"10.1016\/j.ecoenv.2023.114938","volume":"257","author":"C Han","year":"2023","unstructured":"Han C, Sheng J, Pei H, Sheng Y, Wang J, Zhou X, Li W, Cao C, Yang Y (2023) Environmental toxin chlorpyrifos induces liver injury by activating P53-mediated ferroptosis via GSDMD-mtROS. Ecotoxicol Environ Saf 257:114938. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114938","journal-title":"Ecotoxicol Environ Saf"},{"key":"3934_CR16","doi-asserted-by":"publisher","first-page":"1019430","DOI":"10.3389\/fnut.2022.1019430","volume":"9","author":"J Hou","year":"2022","unstructured":"Hou J, Xiang J, Li D, Liu X, Pan W (2022) Gut microbial response to host metabolic phenotypes. Front Nutr 9:1019430. https:\/\/doi.org\/10.3389\/fnut.2022.1019430","journal-title":"Front Nutr"},{"key":"3934_CR17","doi-asserted-by":"publisher","first-page":"110731","DOI":"10.1016\/j.ecoenv.2020.110731","volume":"200","author":"X Huang","year":"2020","unstructured":"Huang X, Cui H, Duan W (2020) Ecotoxicity of chlorpyrifos to aquatic organisms: a review. Ecotoxicol Environ Saf 200:110731. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110731","journal-title":"Ecotoxicol Environ Saf"},{"issue":"11","key":"3934_CR18","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1136\/gutjnl-2016-312297","volume":"65","author":"G Ianiro","year":"2016","unstructured":"Ianiro G, Tilg H, Gasbarrini A (2016) Antibiotics as deep modulators of gut microbiota: between good and evil. Gut 65(11):1906\u20131915. https:\/\/doi.org\/10.1136\/gutjnl-2016-312297","journal-title":"Gut"},{"key":"3934_CR19","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.pestbp.2019.06.006","volume":"159","author":"KA Ibrahim","year":"2019","unstructured":"Ibrahim KA, Khwanes SA, El-Desouky MA, Elhakim HKA (2019) Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression. Pestic Biochem Physiol 159:127\u2013135. https:\/\/doi.org\/10.1016\/j.pestbp.2019.06.006","journal-title":"Pestic Biochem Physiol"},{"issue":"6","key":"3934_CR20","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1007\/s12072-019-09987-8","volume":"13","author":"C Iino","year":"2019","unstructured":"Iino C, Endo T, Mikami K, Hasegawa T, Kimura M, Sawada N, Nakaji S, Fukuda S (2019) Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study. Hepatol Int 13(6):748\u2013756. https:\/\/doi.org\/10.1007\/s12072-019-09987-8","journal-title":"Hepatol Int"},{"issue":"6","key":"3934_CR21","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","volume":"22","author":"K Ishak","year":"1995","unstructured":"Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RN (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22(6):696\u2013699. https:\/\/doi.org\/10.1016\/0168-8278(95)80226-6","journal-title":"J Hepatol"},{"issue":"6","key":"3934_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/toxics9060137","volume":"9","author":"AA Ismail","year":"2021","unstructured":"Ismail AA, Hendy O, Abdel Rasoul G, Olson JR, Bonner MR, Rohlman DS (2021) Acute and cumulative effects of repeated exposure to chlorpyrifos on the liver and kidney function among egyptian adolescents. Toxics 9(6):137. https:\/\/doi.org\/10.3390\/toxics9060137","journal-title":"Toxics"},{"issue":"5","key":"3934_CR23","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1007\/s11356-012-1283-4","volume":"20","author":"C Joly","year":"2013","unstructured":"Joly C, Gay-Qu\u00e9heillard J, L\u00e9k\u00e9 A, Chardon K, Delanaud S, Bach V, Khorsi-Cauet H (2013) Impact of chronic exposure to low doses of chlorpyrifos on the intestinal microbiota in the simulator of the human intestinal microbial ecosystem (SHIME) and in the rat. Environ Sci Pollut Res Int 20(5):2726\u20132734. https:\/\/doi.org\/10.1007\/s11356-012-1283-4","journal-title":"Environ Sci Pollut Res Int"},{"issue":"4","key":"3934_CR24","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/cld.1014","volume":"17","author":"M Krishna","year":"2021","unstructured":"Krishna M (2021) Histological grading and staging of chronic hepatitis. Clin Liver Dis (Hoboken) 17(4):222\u2013226. https:\/\/doi.org\/10.1002\/cld.1014","journal-title":"Clin Liver Dis (Hoboken)"},{"issue":"11","key":"3934_CR25","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/s41564-021-00970-4","volume":"6","author":"MF Laursen","year":"2021","unstructured":"Laursen MF, Sakanaka M, von Burg N, M\u00f6rbe U, Andersen D, Moll JM, Pekmez CT, Rivollier A, Michaelsen KF, M\u00f8lgaard C, Lind MV, Dragsted LO, Katayama T, Frandsen HL, Vinggaard AM, Bahl MI, Brix S, Agace W, Licht TR, Roager HM (2021) Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut. Nat Microbiol 6(11):1367\u20131382. https:\/\/doi.org\/10.1038\/s41564-021-00970-4","journal-title":"Nat Microbiol"},{"key":"3934_CR26","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.chemosphere.2019.05.020","volume":"229","author":"J Li","year":"2019","unstructured":"Li J, Pang G, Ren F, Fang B (2019) Chlorpyrifos-induced reproductive toxicity in rats could be partly relieved under high-fat diet. Chemosphere 229:94\u2013102. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.05.020","journal-title":"Chemosphere"},{"issue":"9","key":"3934_CR27","doi-asserted-by":"publisher","first-page":"e120","DOI":"10.1161\/CIRCRESAHA.122.320184","volume":"131","author":"HB Li","year":"2022","unstructured":"Li HB, Xu ML, Xu XD, Tang YY, Jiang HL, Li L, Xia WJ, Cui N, Bai J, Dai ZM, Han B, Li Y, Peng B, Dong YY, Aryal S, Manandhar I, Eladawi MA, Shukla R, Kang YM, Joe B, Yang T (2022a) Faecalibacterium prausnitzii attenuates CKD via butyrate-renal GPR43 axis. Circ Res 131(9):e120\u2013e134. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.320184","journal-title":"Circ Res"},{"key":"3934_CR28","doi-asserted-by":"publisher","first-page":"120415","DOI":"10.1016\/j.envpol.2022.120415","volume":"315","author":"P Li","year":"2022","unstructured":"Li P, Ma X, Liu D, Wei Y, Li P, Hou H, Yao J, Chen A, Liang Y, Zhou Z, Wang P (2022b) A microbiome abundant environment remodels the intestinal microbiota and improves resistance to obesity induced by chlorpyrifos in mice. Environ Pollut 315:120415. https:\/\/doi.org\/10.1016\/j.envpol.2022.120415","journal-title":"Environ Pollut"},{"issue":"21","key":"3934_CR29","doi-asserted-by":"publisher","first-page":"15968","DOI":"10.3390\/ijms242115968","volume":"24","author":"S Liu","year":"2023","unstructured":"Liu S, Zhu X, Pei H, Zhao Y, Zong Y, Chen W, He Z, Du R (2023) Ginseng stem-and-leaf saponins mitigate chlorpyrifos-evoked intestinal toxicity in vivo and in vitro: oxidative stress, inflammatory response and apoptosis. Int J Mol Sci 24(21):15968. https:\/\/doi.org\/10.3390\/ijms242115968","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3934_CR30","doi-asserted-by":"publisher","first-page":"fuad039","DOI":"10.1093\/femsre\/fuad039","volume":"47","author":"R Mart\u00edn","year":"2023","unstructured":"Mart\u00edn R, Rios-Covian D, Huillet E, Auger S, Khazaal S, Berm\u00fadez-Humar\u00e1n LG, Sokol H, Chatel J-M, Langella P (2023) Faecalibacterium: a bacterial genus with promising human health applications. FEMS Microbiol Rev 47(4):fuad039. https:\/\/doi.org\/10.1093\/femsre\/fuad039","journal-title":"FEMS Microbiol Rev"},{"issue":"1","key":"3934_CR31","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/s42003-021-01990-w","volume":"4","author":"R Mesnage","year":"2021","unstructured":"Mesnage R, Teixeira M, Mandrioli D, Falcioni L, Ibragim M, Ducarmon QR, Zwittink RD, Amiel C, Panoff J-M, Bourne E, Savage E, Mein CA, Belpoggi F, Antoniou MN (2021) Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats. Commun Biol 4(1):471. https:\/\/doi.org\/10.1038\/s42003-021-01990-w","journal-title":"Commun Biol"},{"key":"3934_CR32","doi-asserted-by":"publisher","first-page":"150402","DOI":"10.1016\/j.scitotenv.2021.150402","volume":"805","author":"D Montero","year":"2022","unstructured":"Montero D, Rimoldi S, Torrecillas S, Rapp J, Moroni F, Herrera A, G\u00f3mez M, Fern\u00e1ndez-Montero \u00c1, Terova G (2022) Impact of polypropylene microplastics and chemical pollutants on European sea bass (Dicentrarchus labrax) gut microbiota and health. Sci Total Environ 805:150402. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.150402","journal-title":"Sci Total Environ"},{"issue":"9","key":"3934_CR33","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1177\/0748233711425073","volume":"28","author":"S Mostafalou","year":"2012","unstructured":"Mostafalou S, Eghbal MA, Nili-Ahmadabadi A, Baeeri M, Abdollahi M (2012) Biochemical evidence on the potential role of organophosphates in hepatic glucose metabolism toward insulin resistance through inflammatory signaling and free radical pathways. Toxicol Ind Health 28(9):840\u2013851. https:\/\/doi.org\/10.1177\/0748233711425073","journal-title":"Toxicol Ind Health"},{"issue":"9","key":"3934_CR34","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1039\/d1em00178g","volume":"23","author":"AR Nandhini","year":"2021","unstructured":"Nandhini AR, Harshiny M, Gummadi SN (2021) Chlorpyrifos in environment and food: a critical review of detection methods and degradation pathways. Environ Sci Process Impacts 23(9):1255\u20131277. https:\/\/doi.org\/10.1039\/d1em00178g","journal-title":"Environ Sci Process Impacts"},{"key":"3934_CR35","doi-asserted-by":"publisher","first-page":"105138","DOI":"10.1016\/j.pestbp.2022.105138","volume":"185","author":"NK Nandi","year":"2022","unstructured":"Nandi NK, Vyas A, Akhtar MJ, Kumar B (2022) The growing concern of chlorpyrifos exposures on human and environmental health. Pestic Biochem Physiol 185:105138. https:\/\/doi.org\/10.1016\/j.pestbp.2022.105138","journal-title":"Pestic Biochem Physiol"},{"issue":"6","key":"3934_CR36","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/bcpt.13945","volume":"133","author":"R Nejati","year":"2023","unstructured":"Nejati R, Nematollahi A, Doraghi HK, Sayadi M, Alipanah H (2023) Probiotic bacteria alleviate chlorpyrifos-induced rat testicular and renal toxicity: a possible mechanism based on antioxidant and anti-inflammatory activity. Basic Clin Pharmacol Toxicol 133(6):743\u2013756. https:\/\/doi.org\/10.1111\/bcpt.13945","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"6","key":"3934_CR37","doi-asserted-by":"publisher","first-page":"109113","DOI":"10.1016\/j.celrep.2021.109113","volume":"35","author":"DJ Platt","year":"2021","unstructured":"Platt DJ, Lawrence D, Rodgers R, Schriefer L, Qian W, Miner CA, Menos AM, Kennedy EA, Peterson ST, Stinson WA, Baldridge MT, Miner JJ (2021) Transferrable protection by gut microbes against STING-associated lung disease. Cell Rep 35(6):109113. https:\/\/doi.org\/10.1016\/j.celrep.2021.109113","journal-title":"Cell Rep"},{"issue":"23","key":"3934_CR38","doi-asserted-by":"publisher","first-page":"22529","DOI":"10.1007\/s11356-018-2332-4","volume":"25","author":"M R\u00e9quil\u00e9","year":"2018","unstructured":"R\u00e9quil\u00e9 M, Gonz\u00e0lez Alvarez DO, Delanaud S, Rhazi L, Bach V, Depeint F, Khorsi-Cauet H (2018) Use of a combination of in vitro models to investigate the impact of chlorpyrifos and inulin on the intestinal microbiota and the permeability of the intestinal mucosa. Environ Sci Pollut Res Int 25(23):22529\u201322540. https:\/\/doi.org\/10.1007\/s11356-018-2332-4","journal-title":"Environ Sci Pollut Res Int"},{"key":"3934_CR39","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.neuro.2019.09.013","volume":"75","author":"P Roman","year":"2019","unstructured":"Roman P, Cardona D, Sempere L, Carvajal F (2019) Microbiota and organophosphates. Neurotoxicology 75:200\u2013208. https:\/\/doi.org\/10.1016\/j.neuro.2019.09.013","journal-title":"Neurotoxicology"},{"issue":"10","key":"3934_CR40","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.2174\/1389201024666221025094643","volume":"24","author":"B Roshanravan","year":"2023","unstructured":"Roshanravan B, Farkhondeh T, Darroudi M, Samarghandian S (2023) Protective effect of chrysin against chlorpyrifos-induced hepatotoxicity in rats: biochemical and histopathological approaches in a sub-chronic study. Curr Pharm Biotechnol 24(10):1291\u20131296. https:\/\/doi.org\/10.2174\/1389201024666221025094643","journal-title":"Curr Pharm Biotechnol"},{"key":"3934_CR41","doi-asserted-by":"publisher","first-page":"618582","DOI":"10.3389\/fphys.2021.618582","volume":"12","author":"M Saoudi","year":"2021","unstructured":"Saoudi M, Badraoui R, Rahmouni F, Jamoussi K, El Feki A (2021) Antioxidant and protective effects of artemisia campestris essential oil against chlorpyrifos-induced kidney and liver injuries in rats. Front Physiol 12:618582. https:\/\/doi.org\/10.3389\/fphys.2021.618582","journal-title":"Front Physiol"},{"issue":"6","key":"3934_CR42","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.jhep.2023.07.005","volume":"79","author":"Q Song","year":"2023","unstructured":"Song Q, Zhang X, Liu W, Wei H, Liang W, Zhou Y, Ding Y, Ji F, Ho-Kwan Cheung A, Wong N, Yu J (2023) Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma. J Hepatol 79(6):1352\u20131365. https:\/\/doi.org\/10.1016\/j.jhep.2023.07.005","journal-title":"J Hepatol"},{"key":"3934_CR43","doi-asserted-by":"publisher","first-page":"114470","DOI":"10.1016\/j.ecoenv.2022.114470","volume":"250","author":"Y Sun","year":"2023","unstructured":"Sun Y, Pei J, Chen X, Lin M, Pan Y, Zhang Y, Bai W, Zhou X, Zhang W (2023) The role of the gut microbiota in depressive-like behavior induced by chlorpyrifos in mice. Ecotoxicol Environ Saf 250:114470. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114470","journal-title":"Ecotoxicol Environ Saf"},{"key":"3934_CR44","doi-asserted-by":"publisher","first-page":"104938","DOI":"10.1016\/j.pestbp.2021.104938","volume":"178","author":"MAI Taha","year":"2021","unstructured":"Taha MAI, Badawy MEI, Abdel-Razik RK, Younis HM, Abo-El-Saad MM (2021) Mitochondrial dysfunction and oxidative stress in liver of male albino rats after exposing to sub-chronic intoxication of chlorpyrifos, cypermethrin, and imidacloprid. Pestic Biochem Physiol 178:104938. https:\/\/doi.org\/10.1016\/j.pestbp.2021.104938","journal-title":"Pestic Biochem Physiol"},{"issue":"20","key":"3934_CR45","doi-asserted-by":"publisher","first-page":"6204","DOI":"10.1128\/AEM.01510-16","volume":"82","author":"M Trinder","year":"2016","unstructured":"Trinder M, McDowell TW, Daisley BA, Ali SN, Leong HS, Sumarah MW, Reid G (2016) Probiotic lactobacillus rhamnosus reduces organophosphate pesticide absorption and toxicity to Drosophila melanogaster. Appl Environ Microbiol 82(20):6204\u20136213. https:\/\/doi.org\/10.1128\/AEM.01510-16","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"3934_CR46","doi-asserted-by":"publisher","first-page":"142649","DOI":"10.1016\/j.scitotenv.2020.142649","volume":"755","author":"H Ubaid Ur Rahman","year":"2021","unstructured":"Ubaid Ur Rahman H, Asghar W, Nazir W, Sandhu MA, Ahmed A, Khalid N (2021) A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: evidence of mechanisms, exposures and mitigation strategies. Sci Total Environ 755(2):142649. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.142649","journal-title":"Sci Total Environ"},{"issue":"6","key":"3934_CR47","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.fct.2010.03.051","volume":"48","author":"FG Uzun","year":"2010","unstructured":"Uzun FG, Demir F, Kalender S, Bas H, Kalender Y (2010) Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food Chem Toxicol 48(6):1714\u20131720. https:\/\/doi.org\/10.1016\/j.fct.2010.03.051","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"3934_CR48","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1136\/gutjnl-2019-319766","volume":"69","author":"X Wang","year":"2020","unstructured":"Wang X, Yang S, Li S, Zhao L, Hao Y, Qin J, Zhang L, Zhang C, Bian W, Zuo L, Gao X, Zhu B, Lei XG, Gu Z, Cui W, Xu X, Li Z, Zhu B, Li Y, Chen S, Guo H, Zhang H, Sun J, Zhang M, Hui Y, Zhang X, Liu X, Sun B, Wang L, Qiu Q, Zhang Y, Li X, Liu W, Xue R, Wu H, Shao D, Li J, Zhou Y, Li S, Yang R, Pedersen OB, Yu Z, Ehrlich SD, Ren F (2020) Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut 69(12):2131\u20132142. https:\/\/doi.org\/10.1136\/gutjnl-2019-319766","journal-title":"Gut"},{"issue":"23","key":"3934_CR49","doi-asserted-by":"publisher","first-page":"7771","DOI":"10.3390\/molecules28237771","volume":"28","author":"R Wang","year":"2023","unstructured":"Wang R, Zhang K, Liu K, Pei H, Shi K, He Z, Zong Y, Du R (2023) Protective effect of baicalin on chlorpyrifos-induced liver injury and its mechanism. Molecules 28(23):7771. https:\/\/doi.org\/10.3390\/molecules28237771","journal-title":"Molecules"},{"issue":"3","key":"3934_CR50","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/ismej.2014.177","volume":"9","author":"J Xu","year":"2015","unstructured":"Xu J, Lian F, Zhao L, Zhao Y, Chen X, Zhang X, Guo Y, Zhang C, Zhou Q, Xue Z, Pang X, Zhao L, Tong X (2015) Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. ISME J 9(3):552\u2013562. https:\/\/doi.org\/10.1038\/ismej.2014.177","journal-title":"ISME J"},{"key":"3934_CR51","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.chemosphere.2019.04.088","volume":"227","author":"X Yuan","year":"2019","unstructured":"Yuan X, Pan Z, Jin C, Ni Y, Fu Z, Jin Y (2019) Gut microbiota: an underestimated and unintended recipient for pesticide-induced toxicity. Chemosphere 227:425\u2013434. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.04.088","journal-title":"Chemosphere"},{"issue":"5","key":"3934_CR52","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.chom.2023.04.002","volume":"31","author":"Y Zeng","year":"2023","unstructured":"Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z, Zhao X, Chen P, Gong S (2023) Liberation of daidzein by gut microbial \u03b2-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice. Cell Host Microbe 31(5):766-780.e7. https:\/\/doi.org\/10.1016\/j.chom.2023.04.002","journal-title":"Cell Host Microbe"},{"issue":"1","key":"3934_CR53","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/toxres\/tfaa108","volume":"10","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Jia Q, Hu C, Han M, Guo Q, Li S, Bo C, Zhang Y, Qi X, Sai L, Peng C (2021) Effects of chlorpyrifos exposure on liver inflammation and intestinal flora structure in mice. Toxicol Res (Camb) 10(1):141\u2013149. https:\/\/doi.org\/10.1093\/toxres\/tfaa108","journal-title":"Toxicol Res (Camb)"},{"key":"3934_CR54","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.chemosphere.2016.03.055","volume":"153","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Zhang Y, Wang G, Han R, Xie X (2016) Effects of chlorpyrifos on the gut microbiome and urine metabolome in mouse (Mus musculus). Chemosphere 153:287\u2013293. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.03.055","journal-title":"Chemosphere"},{"issue":"172","key":"3934_CR55","doi-asserted-by":"publisher","first-page":"172ra22","DOI":"10.1126\/scitranslmed.3005114","volume":"5","author":"X Zheng","year":"2013","unstructured":"Zheng X, Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Jia W, Luther M, Su M, Nicholson JK, Jia W (2013) Melamine-induced renal toxicity is mediated by the gut microbiota. Sci Transl Med 5(172):172ra22. https:\/\/doi.org\/10.1126\/scitranslmed.3005114","journal-title":"Sci Transl Med"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03934-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-024-03934-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03934-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T02:36:15Z","timestamp":1739327775000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-024-03934-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["3934"],"URL":"https:\/\/doi.org\/10.1007\/s00204-024-03934-9","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"30 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal procedures were performed in accordance with current China legislation and approved by the Animal and Medical Ethics Committee, which is affiliated with the Institute of Zoology, Chinese Academy of Sciences. All procedures were carried in accordance with the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}