{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:59:26Z","timestamp":1757609966686,"version":"3.44.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00204-025-04101-4","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T14:10:46Z","timestamp":1749219046000},"page":"3825-3837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic alterations in coronary cell lines exposed to sirolimus and paclitaxel"],"prefix":"10.1007","volume":"99","author":[{"given":"Elaine Aparecida","family":"de Camargo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda Nicioli","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo","family":"de Castro Marcondes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"David Corr\u00eaa","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Wilson","family":"Nadruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"D\u00e9cio","family":"Salvadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-3379","authenticated-orcid":false,"given":"Daisy Maria F\u00e1vero","family":"Salvadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"issue":"5","key":"4101_CR1","doi-asserted-by":"publisher","first-page":"e355","DOI":"10.4244\/EIJV17I5A60","volume":"17","author":"F Alfonso","year":"2021","unstructured":"Alfonso F, Kastrati A (2021) Clinical burden and implications of coronary interventions for in-stent restenosis. EuroIntervention 17(5):e355\u2013e357. https:\/\/doi.org\/10.4244\/EIJV17I5A60","journal-title":"EuroIntervention"},{"issue":"2","key":"4101_CR2","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.4244\/EIJ-D-21-01034","volume":"18","author":"F Alfonso","year":"2022","unstructured":"Alfonso F, Coughlan JJ, Giacoppo D, Kastrati A, Byrne RA (2022) Management of in-stent restenosis. EuroIntervention 18(2):e103\u2013e123. https:\/\/doi.org\/10.4244\/EIJ-D-21-01034","journal-title":"EuroIntervention"},{"issue":"1","key":"4101_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1113\/expphysiol.2005.031765","volume":"91","author":"SL Alper","year":"2006","unstructured":"Alper SL (2006) Molecular physiology of SLC4 anion exchangers. Exp Physiol 91(1):153\u2013161. https:\/\/doi.org\/10.1113\/expphysiol.2005.031765","journal-title":"Exp Physiol"},{"issue":"1","key":"4101_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2012.08.025","volume":"225","author":"S Banerjee","year":"2012","unstructured":"Banerjee S, Xu H, Fuh E, Nguyen KT, Garcia JA, Brilakis ES, Bhatt DL (2012) Endothelial progenitor cell response to antiproliferative drug exposure. Atherosclerosis 225(1):91\u201398. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.08.025","journal-title":"Atherosclerosis"},{"issue":"3","key":"4101_CR5","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/cvr\/cvn024","volume":"78","author":"A Barilli","year":"2008","unstructured":"Barilli A, Visigalli R, Sala R, Gazzola GC, Parolari A, Tremoli E, Bonomini S, Simon A, Closs EI, Dall\u2019Asta V, Bussolati O (2008) In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function. Cardiovasc Res 78(3):563\u2013571. https:\/\/doi.org\/10.1093\/cvr\/cvn024","journal-title":"Cardiovasc Res"},{"key":"4101_CR49","doi-asserted-by":"publisher","first-page":"175287","DOI":"10.1016\/j.ejphar.2022.175287","volume":"933","author":"JN Blom","year":"2024","unstructured":"Blom JN, Wang X, Lu X, Kim MY, Wang G, Feng Q (2022) Inhibition of intraflagellar transport protein-88 promotes epithelial-to-mesenchymal transition and reduces cardiac remodeling post-myocardial infarction. Eur J Pharmacol 933:175287. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175287","journal-title":"Eur J Pharmacol"},{"issue":"51","key":"4101_CR6","doi-asserted-by":"publisher","first-page":"42397","DOI":"10.1074\/jbc.M506724200","volume":"280","author":"S Bohman","year":"2005","unstructured":"Bohman S, Matsumoto T, Suh K, Dimberg A, Jakobsson L, Yuspa S, Claesson-Welsh L (2005) Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis. J Biol Chem 280(51):42397\u201342404. https:\/\/doi.org\/10.1074\/jbc.M506724200","journal-title":"J Biol Chem"},{"issue":"7","key":"4101_CR7","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1161\/hq0701.092104","volume":"21","author":"RC Braun-Dullaeus","year":"2001","unstructured":"Braun-Dullaeus RC, Mann MJ, Seay U, Zhang L, von Der Leyen HE, Morris RE, Dzau VJ (2001) Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin. Arterioscler Thromb Vasc Biol 21(7):1152\u20131158. https:\/\/doi.org\/10.1161\/hq0701.092104","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"47","key":"4101_CR8","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1093\/eurheartj\/ehv511","volume":"36","author":"RA Byrne","year":"2015","unstructured":"Byrne RA, Joner M, Kastrati A (2015) Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Gr\u00fcntzig Lecture ESC 2014. Eur Heart J 36(47):3320\u20133331. https:\/\/doi.org\/10.1093\/eurheartj\/ehv511","journal-title":"Eur Heart J"},{"issue":"3","key":"4101_CR9","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.bioactmat.2020.09.005","volume":"6","author":"Y Chen","year":"2020","unstructured":"Chen Y, Zeng Y, Zhu X, Miao L, Liang X, Duan J, Li H, Tian X, Pang L, Wei Y, Yang J (2020) Significant difference between sirolimus and paclitaxel nanoparticles in anti-proliferation effect in normoxia and hypoxia: the basis of better selection of atherosclerosis treatment. Bioact Mater 6(3):880\u2013889. https:\/\/doi.org\/10.1016\/j.bioactmat.2020.09.005","journal-title":"Bioact Mater"},{"issue":"4","key":"4101_CR10","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1007\/s00210-023-02757-2","volume":"397","author":"R Chen","year":"2024","unstructured":"Chen R, Fang T, Liu N, Shi X, Wang J, Yu H (2024) Transglutaminase 3 suppresses proliferation and cisplatin resistance of cervical cancer cells by inactivation of the PI3K\/AKT pathway. Naunyn Schmiedebergs Arch Pharmacol 397(4):2269\u20132280. https:\/\/doi.org\/10.1007\/s00210-023-02757-2","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4101_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1385\/MB:26:3:249","volume":"26","author":"AR Collins","year":"2004","unstructured":"Collins AR (2004) The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 26:249\u2013261. https:\/\/doi.org\/10.1385\/MB:26:3:249","journal-title":"Mol Biotechnol"},{"issue":"Suppl 3","key":"4101_CR12","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1289\/ehp.96104s3465","volume":"104","author":"AR Collins","year":"1996","unstructured":"Collins AR, Dusinsk\u00e1 M, Gedik CM, St\u0115tina R (1996) Oxidative damage to DNA: do we have a reliable biomarker? Environ Health Perspect 104(Suppl 3):465\u2013469. https:\/\/doi.org\/10.1289\/ehp.96104s3465","journal-title":"Environ Health Perspect"},{"issue":"Pt C","key":"4101_CR13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.pnpbp.2017.06.036","volume":"80","author":"P Czarny","year":"2018","unstructured":"Czarny P, Wigner P, Galecki P, Sliwinski T (2018) The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression. Prog Neuropsychopharmacol Biol Psychiatry 80(Pt C):309\u2013321. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.06.036","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"4","key":"4101_CR14","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","volume":"99","author":"DP Del Re","year":"2019","unstructured":"Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN (2019) Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev 99(4):1765\u20131817. https:\/\/doi.org\/10.1152\/physrev.00022.2018","journal-title":"Physiol Rev"},{"issue":"1\u20132","key":"4101_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.canlet.2012.01.016","volume":"327","author":"M Dizdaroglu","year":"2012","unstructured":"Dizdaroglu M (2012) Oxidatively induced DNA damage: mechanisms, repair and disease. Cancer Lett 327(1\u20132):26\u201347. https:\/\/doi.org\/10.1016\/j.canlet.2012.01.016","journal-title":"Cancer Lett"},{"key":"4101_CR50","doi-asserted-by":"publisher","first-page":"864","DOI":"10.3892\/or.2020.7474","volume":"43","author":"Y Feng","year":"2020","unstructured":"Feng Y, Ji D, Huang Y, Ji B, Zhang Y, Li J, Peng W, Zhang C, Zhang D, Sun Y, Xu Z (2020) TGM3 functions as a tumor suppressor by repressing epithelial\u2011to\u2011mesenchymal transition and the PI3K\/AKT signaling pathway in colorectal cancer. Oncol Rep 43:864\u2013876. https:\/\/doi.org\/10.3892\/or.2020.7474","journal-title":"Oncol Rep"},{"issue":"10","key":"4101_CR16","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1161\/ATVBAHA.113.301659","volume":"33","author":"A Habib","year":"2013","unstructured":"Habib A, Karmali V, Polavarapu R, Akahori H, Cheng Q, Pachura K, Kolodgie FD, Finn AV (2013) Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-\u03b1 activation and disruption of the p120-vascular endothelial cadherin interaction. Arterioscler Thromb Vasc Biol 33(10):2425\u20132431. https:\/\/doi.org\/10.1161\/ATVBAHA.113.301659","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"4101_CR17","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3390\/ijms25021295","volume":"25","author":"JY Kan","year":"2024","unstructured":"Kan JY, Shih SL, Yang SF, Chu PY, Chen FM, Li CL, Wu YC, Yeh YT, Hou MF, Chiang CP (2024) Exosomal microRNA-92b is a diagnostic biomarker in breast cancer and targets survival-related MTSS1L to promote tumorigenesis. Int J Mol Sci 25(2):1295. https:\/\/doi.org\/10.3390\/ijms25021295","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4101_CR18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.21470\/1678-9741-2020-0179","volume":"37","author":"Y Kang","year":"2022","unstructured":"Kang Y, Cai Y, Pan W (2022) Rapamycin and paclitaxel affect human aortic smooth muscle cells-derived foam cells viability and proliferation. Braz J Cardiovasc Surg 37(2):200\u2013206. https:\/\/doi.org\/10.21470\/1678-9741-2020-0179","journal-title":"Braz J Cardiovasc Surg"},{"key":"4101_CR19","doi-asserted-by":"publisher","first-page":"5569","DOI":"10.1038\/s41586-018-0716-5","volume":"37","author":"S Lee","year":"2018","unstructured":"Lee S, Axelsen TV, Jessen N, Pedersen SF, Vahl P, Boedtkjer E (2018) Na+, HCO3\u2212-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice. Oncogene 37:5569\u20135584. https:\/\/doi.org\/10.1038\/s41586-018-0716-5","journal-title":"Oncogene"},{"issue":"2","key":"4101_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23654","volume":"38","author":"J Li","year":"2024","unstructured":"Li J, Zhang J, Chu Z, Han H, Zhang Y (2024) FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway. J Biochem Mol Toxicol 38(2):e23654. https:\/\/doi.org\/10.1002\/jbt.23654","journal-title":"J Biochem Mol Toxicol"},{"issue":"9","key":"4101_CR21","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1002\/ijc.25815","volume":"128","author":"P Lonkar","year":"2011","unstructured":"Lonkar P, Dedon PC (2011) Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. Int J Cancer 128(9):1999\u20132009. https:\/\/doi.org\/10.1002\/ijc.25815","journal-title":"Int J Cancer"},{"key":"4101_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-024-05761-y","author":"X Mao","year":"2024","unstructured":"Mao X, Huang W, Xue Q, Zhang X (2024) Prognostic impact and immunotherapeutic implications of NETosis-related prognostic model in clear cell renal cell carcinoma. J Cancer Res Clin Oncol. https:\/\/doi.org\/10.1007\/s00432-024-05761-y","journal-title":"J Cancer Res Clin Oncol"},{"key":"4101_CR23","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1038\/s41596-020-0398-1","volume":"15","author":"P M\u00f8ller","year":"2020","unstructured":"M\u00f8ller P, Azqueta A, Boutet-Robinet E, Koppen G, Bonassi S, Milic M, Gajski G, Costa S, Teixeira JP, Pereira CC, Dusinska M, Godschalk R, Brunborg G, Gutzkow KB, Giovanelli L, Cooke MS, Richling E, Laffon B, Valdiglesias V, Basaran N, Del Bo C, Zegura B, Novak M, Stopper H, Vodicka P, Vodenkova S, Andrade VM, Sramkova M, Gabelova A, Collins A, Langie SAS (2020) Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results. Nat Protocol 15:3817\u20133826. https:\/\/doi.org\/10.1038\/s41596-020-0398-1","journal-title":"Nat Protocol"},{"key":"4101_CR24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cardiores.2005.05.011","volume":"68","author":"W Nadruz Jr","year":"2005","unstructured":"Nadruz W Jr, Corat MA, Marin TM, Guimar\u00e3es Pereira GA, Franchini KG (2005) Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: role in the activation of the cardiac hypertrophic genetic program. Cardiovasc Res 68:87\u201397. https:\/\/doi.org\/10.1016\/j.cardiores.2005.05.011","journal-title":"Cardiovasc Res"},{"issue":"1","key":"4101_CR51","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1038\/s41598-023-28475-6","volume":"13","author":"W Niu","year":"2023","unstructured":"Niu W, Zhang T, Ma L (2023) Correlation analysis between immune-related genes and cell infiltration revealed prostate cancer immunotherapy biomarkers linked to T cells gamma delta. Sci Rep 13(1):2459. https:\/\/doi.org\/10.1038\/s41598-023-28475-6","journal-title":"Sci Rep"},{"key":"4101_CR25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ejphar.2005.09.042","volume":"524","author":"TJ Parry","year":"2005","unstructured":"Parry TJ, Brosius R, Thyagarajan R, Carter D, Argentieri D, Falotico R, Siekierka J (2005) Drug-eluting stents: sirolimus and paclitaxel differentially affect cultured cells and injured arteries. Eur J Pharmacol 524:19\u201329. https:\/\/doi.org\/10.1016\/j.ejphar.2005.09.042","journal-title":"Eur J Pharmacol"},{"key":"4101_CR26","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.molmet.2015.01.003","volume":"4","author":"D Patel","year":"2015","unstructured":"Patel D, Ythier D, Brozzi F, Eizirik DL, Thorens B (2015) Clic4, a novel protein that sensitizes \u03b2-cells to apoptosis. Mol Metab 4:253\u2013264. https:\/\/doi.org\/10.1016\/j.molmet.2015.01.003","journal-title":"Mol Metab"},{"key":"4101_CR27","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1126\/sciadv.abo1244","volume":"8","author":"D Ponnalagu","year":"2022","unstructured":"Ponnalagu D, Hamilton S, Sanghvi S, Antelo D, Schwieterman N, Hansra I, Xu X, Gao E, Edwards JC, Bansal SS, Wold LE, Terentyev D, Janssen PML, Hund TJ, Khan M, Kohut AR, Koch WJ, Singh H (2022) CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection. Sci Adv 8:1244. https:\/\/doi.org\/10.1126\/sciadv.abo1244","journal-title":"Sci Adv"},{"key":"4101_CR28","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1016\/j.febslet.2011.09.030","volume":"585","author":"K Raman","year":"2011","unstructured":"Raman K, Nguyen TK, Kuberan B (2011) Is N-sulfation just a gateway modification during heparan sulfate biosynthesis? FEBS Lett 585:3420\u20133423. https:\/\/doi.org\/10.1016\/j.febslet.2011.09.030","journal-title":"FEBS Lett"},{"key":"4101_CR29","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004952","volume":"3","author":"S Sarrazin","year":"2011","unstructured":"Sarrazin S, Lamanna WC, Esko JD (2011) Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol 3:a004952. https:\/\/doi.org\/10.1101\/cshperspect.a004952","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"4101_CR30","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/s41598-023-27679-0","volume":"13","author":"KT Sawicki","year":"2023","unstructured":"Sawicki KT, Nannini DR, Bielinski SJ, Larson NB, Lloyd-Jones DM, Psaty B, Taylor KD, Shah SJ, Rasmussen-Torvik LJ, Wilkins JT, McNally EM, Patel RB (2023) Secretory leukocyte protease inhibitor and risk of heart failure in the Multi-Ethnic Study of Atherosclerosis. Sci Rep 13:604. https:\/\/doi.org\/10.1038\/s41598-023-27679-0","journal-title":"Sci Rep"},{"key":"4101_CR31","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1007\/s00270-013-0583-5","volume":"36","author":"J Schmehl","year":"2013","unstructured":"Schmehl J, von der Ruhr J, Dobratz M, Kehlbach R, Braun I, Greiner TO, Claussen CD, Behnisch B (2013) Balloon coating with rapamycin using an on-site coating device. Cardiovasc Intervent Radiol 36:756\u2013763. https:\/\/doi.org\/10.1007\/s00270-013-0583-5","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4101_CR32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007023","volume":"12","author":"E Shlofmitz","year":"2019","unstructured":"Shlofmitz E, Iantorno M, Waksman R (2019) Restenosis of drug-eluting stents: a new classification system based on disease mechanism to guide treatment and state-of-the-art review. Circ Cardiovasc Interv 12:e007023. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.118.007023","journal-title":"Circ Cardiovasc Interv"},{"key":"4101_CR33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","volume":"175","author":"NP Singh","year":"1988","unstructured":"Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184\u2013191","journal-title":"Exp Cell Res"},{"issue":"1","key":"4101_CR52","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s11357-022-00648-7","volume":"45","author":"K Takaya","year":"2023","unstructured":"Takaya K, Asou T, Kishi K (2023) Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging. Geroscience 45(1):427\u2013437. https:\/\/doi.org\/10.1007\/s11357-022-00648-7","journal-title":"Geroscience"},{"key":"4101_CR34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/978-1-4684-5877-0_17","volume":"283","author":"RR Tice","year":"1991","unstructured":"Tice RR, Andrews PW, Hirai O, Singh NP (1991) The single cell gel (SCG) assay: an electrophoretic technique for the detection of DNA damage in individual cells. Adv Exp Med Biol 283:157\u2013164. https:\/\/doi.org\/10.1007\/978-1-4684-5877-0_17","journal-title":"Adv Exp Med Biol"},{"key":"4101_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10456-009-9139-3","volume":"12","author":"JJ Tung","year":"2009","unstructured":"Tung JJ, Hobert O, Berryman M, Kitajewski J (2009) Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro. Angiogenesis 12:209\u2013220. https:\/\/doi.org\/10.1007\/s10456-009-9139-3","journal-title":"Angiogenesis"},{"key":"4101_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067040","volume":"8","author":"ST Tzeng","year":"2013","unstructured":"Tzeng ST, Tsai MH, Chen CL, Lee JX, Jao TM, Yu SL, Yen SJ, Yang YC (2013) NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer. PLoS ONE 8:e67040. https:\/\/doi.org\/10.1371\/journal.pone.0067040","journal-title":"PLoS ONE"},{"key":"4101_CR37","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.2353\/ajpath.2009.080625","volume":"174","author":"B Ulmasov","year":"2009","unstructured":"Ulmasov B, Bruno J, Gordon N, Hartnett ME, Edwards JC (2009) Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway. Am J Pathol 174:1084\u20131096. https:\/\/doi.org\/10.2353\/ajpath.2009.080625","journal-title":"Am J Pathol"},{"key":"4101_CR38","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.4049\/jimmunol.1302552","volume":"192","author":"Y Wang","year":"2014","unstructured":"Wang Y, Hu L, Tong X, Ye X (2014) Casein kinase 1\u03b31 inhibits the RIG-I\/TLR signaling pathway through phosphorylating p65 and promoting its degradation. J Immunol 192:1855\u20131861. https:\/\/doi.org\/10.4049\/jimmunol.1302552","journal-title":"J Immunol"},{"key":"4101_CR39","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.3892\/ijo.2018.4521","volume":"53","author":"Z Wang","year":"2018","unstructured":"Wang Z, Zhao X, Wang W, Liu Y, Li Y, Gao J, Wang C, Zhou M, Liu R, Xu G, Zhou Q (2018) ZBTB7 evokes 5-fluorouracil resistance in colorectal cancer through the NF-\u03baB signaling pathway. Int J Oncol 53:2102\u20132110. https:\/\/doi.org\/10.3892\/ijo.2018.4521","journal-title":"Int J Oncol"},{"key":"4101_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2025.119903","author":"L Wang","year":"2025","unstructured":"Wang L, Na L, Chen Y, Qiao Y, Song Y, Zhang X, Zhao H, Ran W, Li G, Xing X (2025) GPSM1 interacts and cooperates with MMP19 to promote proliferation and EMT in colorectal cancer cells. Biochim Biophys Acta Mol Cell Res. https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119903","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"4101_CR41","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/1476-4598-12-151","volume":"12","author":"X Wu","year":"2013","unstructured":"Wu X, Cao W, Wang X, Zhang J, Lv Z, Qin X, Wu Y, Chen W (2013) TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer. Mol Cancer 12:151. https:\/\/doi.org\/10.1186\/1476-4598-12-151","journal-title":"Mol Cancer"},{"key":"4101_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115208","volume":"165","author":"J Xu","year":"2023","unstructured":"Xu J, Sun Y, Fu W, Fu S (2023) MYCT1 in cancer development: gene structure, regulation, and biological implications for diagnosis and treatment. Biomed Pharmacother 165:115208. https:\/\/doi.org\/10.1016\/j.biopha.2023.115208","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"4101_CR53","doi-asserted-by":"publisher","first-page":"8306","DOI":"10.18632\/aging.202638","volume":"13","author":"Y Yang","year":"2021","unstructured":"Yang Y, Xu X (2021) Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration. Aging (Albany NY) 13(6):8306\u20138319. https:\/\/doi.org\/10.18632\/aging.202638","journal-title":"Aging (Albany NY)"},{"key":"4101_CR43","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3892\/mmr.2012.846","volume":"5","author":"X Yang","year":"2012","unstructured":"Yang X, Zu X, Tang J, Xiong W, Zhang Y, Liu F, Jiang Y (2012) Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: implications for the role of Zbtb7 in cell cycle regulation. Mol Med Rep 5:1475\u20131480. https:\/\/doi.org\/10.3892\/mmr.2012.846","journal-title":"Mol Med Rep"},{"key":"4101_CR44","first-page":"3378","volume":"7","author":"ZX Zhang","year":"2014","unstructured":"Zhang ZX, Zhang Y (2014) Glutathione S-transferase M1 (GSTM1) null genotype and coronary artery disease risk: a meta-analysis. Int J Clin Exp Med 7:3378\u20133384","journal-title":"Int J Clin Exp Med"},{"key":"4101_CR45","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/ijms24021231","volume":"24","author":"H Zhang","year":"2023","unstructured":"Zhang H, Chen B, Waliullah ASM, Aramaki S, Ping Y, Takanashi Y, Zhang C, Zhai Q, Yan J, Oyama S, Kahyo T, Setou M (2023) A new potential therapeutic target for cancer in ubiquitin-like proteins-UBL3. Int J Mol Sci 24:1231. https:\/\/doi.org\/10.3390\/ijms24021231","journal-title":"Int J Mol Sci"},{"key":"4101_CR46","doi-asserted-by":"publisher","first-page":"15166","DOI":"10.3390\/ijms242015166","volume":"24","author":"J Zhong","year":"2023","unstructured":"Zhong J, Dong J, Ruan W, Duan X (2023) Potential theranostic roles of SLC4 molecules in human diseases. Int J Mol Sci 24:15166. https:\/\/doi.org\/10.3390\/ijms242015166","journal-title":"Int J Mol Sci"},{"key":"4101_CR47","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41419-024-06626-5","volume":"15","author":"K Zhou","year":"2024","unstructured":"Zhou K, Wu C, Cheng W, Zhang B, Wei R, Cheng D, Li Y, Cao Y, Zhang W, Yao Z, Zhang X (2024a) Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation. Cell Death Dis 15:252. https:\/\/doi.org\/10.1038\/s41419-024-06626-5","journal-title":"Cell Death Dis"},{"key":"4101_CR48","doi-asserted-by":"publisher","first-page":"13556","DOI":"10.1038\/s41598-024-64542-2","volume":"14","author":"X Zhou","year":"2024","unstructured":"Zhou X, Chen H, Huang D, Guan G, Ma X, Cai W, Liao J, Guan T (2024b) Reduced expression of cathepsin F predicts poor prognosis in patients with clear cell renal cell carcinoma. Sci Rep 14:13556. https:\/\/doi.org\/10.1038\/s41598-024-64542-2","journal-title":"Sci Rep"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04101-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-025-04101-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04101-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:42:43Z","timestamp":1756903363000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-025-04101-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4101"],"URL":"https:\/\/doi.org\/10.1007\/s00204-025-04101-4","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"type":"print","value":"0340-5761"},{"type":"electronic","value":"1432-0738"}],"subject":[],"published":{"date-parts":[[2025,6,6]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}