{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:37:32Z","timestamp":1793489852071,"version":"4.5.0"},"reference-count":367,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00204-025-04235-5","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:01:15Z","timestamp":1765353675000},"page":"837-874","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis"],"prefix":"10.1007","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-9498","authenticated-orcid":false,"given":"Anouk","family":"Verhoeven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-2752","authenticated-orcid":false,"given":"Julen","family":"Sanz-Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-8893","authenticated-orcid":false,"given":"Mathieu","family":"Vinken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"issue":"1","key":"4235_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1093\/toxsci\/kfad044","volume":"194","author":"GC Addicks","year":"2023","unstructured":"Addicks GC, Rowan-Carroll A, Reardon AJF, Leingartner K, Williams A, Meier MJ, Moffat I, Carrier R, Lorusso L, Wetmore BA, Yauk CL, Atlas E (2023) Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids. Toxicol Sci 194(1):38\u201352. https:\/\/doi.org\/10.1093\/toxsci\/kfad044","journal-title":"Toxicol Sci"},{"key":"4235_CR2","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.tox.2014.02.007","volume":"332","author":"Y Adeleye","year":"2015","unstructured":"Adeleye Y, Andersen M, Clewell R et al (2015) Implementing toxicity testing in the 21st century (TT21C): making safety decisions using toxicity pathways, and progress in a prototype risk assessment. Toxicology 332:102\u2013111. https:\/\/doi.org\/10.1016\/j.tox.2014.02.007","journal-title":"Toxicology"},{"key":"4235_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.mito.2018.02.009","volume":"46","author":"MM Adeva-Andany","year":"2019","unstructured":"Adeva-Andany MM, Carneiro-Freire N, Seco-Filgueira M et al (2019) Mitochondrial \u03b2-oxidation of saturated fatty acids in humans. Mitochondrion 46:73\u201390. https:\/\/doi.org\/10.1016\/j.mito.2018.02.009","journal-title":"Mitochondrion"},{"key":"4235_CR4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3389\/fgene.2018.00396","volume":"9","author":"A Aguayo-Orozco","year":"2018","unstructured":"Aguayo-Orozco A, Bois FY, Brunak S, Taboureau O (2018) Analysis of time-series gene expression data to explore mechanisms of chemical-induced hepatic steatosis toxicity. Front Genet 9:396. https:\/\/doi.org\/10.3389\/fgene.2018.00396","journal-title":"Front Genet"},{"issue":"1","key":"4235_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bcp.2015.09.004","volume":"98","author":"C Ahowesso","year":"2015","unstructured":"Ahowesso C, Black PN, Saini N, Montefusco D, Chekal J, Malosh C, Lindsley CW, Stauffer SR, DiRusso CC (2015) Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death. Biochem Pharmacol 98(1):167\u2013181. https:\/\/doi.org\/10.1016\/j.bcp.2015.09.004","journal-title":"Biochem Pharmacol"},{"key":"4235_CR6","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.bcp.2009.10.011","volume":"79","author":"CCP Aires","year":"2010","unstructured":"Aires CCP, IJlst L, Stet F et al (2010) Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. Biochem Pharmacol 79:792\u2013799. https:\/\/doi.org\/10.1016\/j.bcp.2009.10.011","journal-title":"Biochem Pharmacol"},{"key":"4235_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00204-021-03182-1","volume":"96","author":"J Alarcan","year":"2022","unstructured":"Alarcan J, de Sousa G, Katsanou ES et al (2022) Investigating the in vitro steatotic mixture effects of similarly and dissimilarly acting test compounds using an adverse outcome pathway-based approach. Arch Toxicol 96:211\u2013229. https:\/\/doi.org\/10.1007\/s00204-021-03182-1","journal-title":"Arch Toxicol"},{"key":"4235_CR8","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1007\/s00204-019-02492-9","volume":"93","author":"W Albrecht","year":"2019","unstructured":"Albrecht W, Kappenberg F, Brecklinghaus T et al (2019) Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93:1609\u20131637. https:\/\/doi.org\/10.1007\/s00204-019-02492-9","journal-title":"Arch Toxicol"},{"key":"4235_CR9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/metabo10060231","volume":"10","author":"J Aldana","year":"2020","unstructured":"Aldana J, Romero-Otero A, Cala MP (2020) Exploring the lipidome: current lipid extraction techniques for mass spectrometry analysis. Metabolites 10:231. https:\/\/doi.org\/10.3390\/metabo10060231","journal-title":"Metabolites"},{"key":"4235_CR10","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1177\/0192623314549960","volume":"43","author":"L Al-Eryani","year":"2015","unstructured":"Al-Eryani L, Wahlang B, Falkner KC et al (2015) Identification of environmental chemicals associated with the development of toxicant associated fatty liver disease in rodents. Toxicol Pathol 43:482\u2013497. https:\/\/doi.org\/10.1177\/0192623314549960","journal-title":"Toxicol Pathol"},{"issue":"2","key":"4235_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10565-020-09537-1","volume":"37","author":"J Allard","year":"2021","unstructured":"Allard J, Bucher S, Massart J, Ferron P-J, Le Guillou D, Loyant R, Daniel Y, Launay Y, Buron N, Begriche K, Borgne-Sanchez A, Fromenty B (2021) Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol 37(2):151\u2013175. https:\/\/doi.org\/10.1007\/s10565-020-09537-1","journal-title":"Cell Biol Toxicol"},{"key":"4235_CR12","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1517\/17425255.2011.577740","volume":"7","author":"DE Amacher","year":"2011","unstructured":"Amacher DE (2011) The mechanistic basis for the induction of hepatic steatosis by xenobiotics. Expert Opin Drug Metab Toxicol 7:949\u2013965. https:\/\/doi.org\/10.1517\/17425255.2011.577740","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"4235_CR13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1055\/s-0034-1375960","volume":"34","author":"D Amacher","year":"2014","unstructured":"Amacher D, Chalasani N (2014) Drug-induced hepatic steatosis. Semin Liver Dis 34:205\u2013214. https:\/\/doi.org\/10.1055\/s-0034-1375960","journal-title":"Semin Liver Dis"},{"key":"4235_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/toxsci\/kfs155","volume":"128","author":"MM Angrish","year":"2012","unstructured":"Angrish MM, Mets BD, Jones AD, Zacharewski TR (2012) Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-\u03c1-dioxin (TCDD)-elicited hepatic steatosis in C57BL\/6 mice. Toxicol Sci 128:377\u2013386. https:\/\/doi.org\/10.1093\/toxsci\/kfs155","journal-title":"Toxicol Sci"},{"key":"4235_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/toxsci\/kfx121","volume":"159","author":"MM Angrish","year":"2017","unstructured":"Angrish MM, McQueen CA, Cohen-Hubal E et al (2017) Mechanistic toxicity tests based on an adverse outcome pathway network for hepatic steatosis. Toxicol Sci off J Soc Toxicol 159:159\u2013169. https:\/\/doi.org\/10.1093\/toxsci\/kfx121","journal-title":"Toxicol Sci off J Soc Toxicol"},{"issue":"3","key":"4235_CR16","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/etc.34","volume":"29","author":"GT Ankley","year":"2010","unstructured":"Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR, Nichols JW, Russom CL, Schmieder PK, Serrrano JA, Tietge JE, Villeneuve DL (2010) Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem 29(3):730\u2013741. https:\/\/doi.org\/10.1002\/etc.34","journal-title":"Environ Toxicol Chem"},{"issue":"6","key":"4235_CR17","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1002\/hep.24290","volume":"53","author":"S Anth\u00e9rieu","year":"2011","unstructured":"Anth\u00e9rieu S, Rogue A, Fromenty B, Guillouzo A, Robin M-A (2011) Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells. Hepatology 53(6):1895\u20131905. https:\/\/doi.org\/10.1002\/hep.24290","journal-title":"Hepatology"},{"issue":"5","key":"4235_CR18","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1021\/acs.bioconjchem.7b00048","volume":"28","author":"H Appelqvist","year":"2017","unstructured":"Appelqvist H, Stranius K, B\u00f6rjesson K, Nilsson KPR, Dyrager C (2017) Specific imaging of intracellular lipid droplets using a benzothiadiazole derivative with solvatochromic properties. Bioconjug Chem 28(5):1363\u20131370. https:\/\/doi.org\/10.1021\/acs.bioconjchem.7b00048","journal-title":"Bioconjug Chem"},{"issue":"11","key":"4235_CR19","doi-asserted-by":"publisher","first-page":"22052","DOI":"10.3390\/ijms141122052","volume":"14","author":"M Arciello","year":"2013","unstructured":"Arciello M, Gori M, Maggio R, Barbaro B, Tarocchi M, Galli A, Balsano C (2013) Environmental pollution: a tangible risk for NAFLD pathogenesis. Int J Mol Sci 14(11):22052\u201322066. https:\/\/doi.org\/10.3390\/ijms141122052","journal-title":"Int J Mol Sci"},{"key":"4235_CR20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s40572-019-00231-x","volume":"6","author":"LE Armstrong","year":"2019","unstructured":"Armstrong LE, Guo GL (2019) Understanding environmental contaminants\u2019 direct effects on non-alcoholic fatty liver disease progression. Curr Environ Health Rep 6:95\u2013104. https:\/\/doi.org\/10.1007\/s40572-019-00231-x","journal-title":"Curr Environ Health Rep"},{"key":"4235_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152856","volume":"459","author":"E Arnesdotter","year":"2021","unstructured":"Arnesdotter E, Spinu N, Firman J, Ebbrell D, Cronin MTD, Vanhaecke T, Vinken M (2021) Derivation, characterisation and analysis of an adverse outcome pathway network for human hepatotoxicity. Toxicology 459:152856. https:\/\/doi.org\/10.1016\/j.tox.2021.152856","journal-title":"Toxicology"},{"key":"4235_CR22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-1-4939-6960-9_2","volume-title":"Cell viability assays: methods and protocols","author":"G Ates","year":"2017","unstructured":"Ates G, Vanhaecke T, Rogiers V, Rodrigues RM (2017) Assaying cellular viability using the neutral red uptake assay. In: Gilbert DF, Friedrich O (eds) Cell viability assays: methods and protocols. Springer, New York, New York, NY, pp 19\u201326"},{"key":"4235_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.taap.2017.03.022","volume":"324","author":"X Bai","year":"2017","unstructured":"Bai X, Hong W, Cai P, Chen Y, Xu C, Cao Di, Yu W, Zhao Z, Huang M, Jin J (2017) Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis. Toxicol Appl Pharmacol 324:12\u201325. https:\/\/doi.org\/10.1016\/j.taap.2017.03.022","journal-title":"Toxicol Appl Pharmacol"},{"key":"4235_CR24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12302-019-0195-z","volume":"31","author":"L Bajard","year":"2019","unstructured":"Bajard L, Melymuk L, Blaha L (2019) Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and adverse outcome pathways. Environ Sci Eur 31:14. https:\/\/doi.org\/10.1186\/s12302-019-0195-z","journal-title":"Environ Sci Eur"},{"key":"4235_CR25","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00204-021-03215-9","volume":"96","author":"N Ball","year":"2022","unstructured":"Ball N, Bars R, Botham PA et al (2022) A framework for chemical safety assessment incorporating new approach methodologies within REACH. Arch Toxicol 96:743\u2013766. https:\/\/doi.org\/10.1007\/s00204-021-03215-9","journal-title":"Arch Toxicol"},{"key":"4235_CR26","doi-asserted-by":"publisher","unstructured":"Bal-Price A (2018) Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX 306\u2013352. https:\/\/doi.org\/10.14573\/altex.1712081","DOI":"10.14573\/altex.1712081"},{"key":"4235_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2024.100160","volume":"11","author":"S Basak","year":"2024","unstructured":"Basak S, Murmu A, Matore BW, Roy PP, Singh J (2024) Thiazolidinedione an auspicious scaffold as PPAR-\u03b3 agonist: its possible mechanism to manoeuvre against insulin resistant diabetes mellitus. Eur J Med Chem Rep 11:100160. https:\/\/doi.org\/10.1016\/j.ejmcr.2024.100160","journal-title":"Eur J Med Chem Rep"},{"key":"4235_CR28","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41573-021-00367-2","volume":"21","author":"B Batchuluun","year":"2022","unstructured":"Batchuluun B, Pinkosky SL, Steinberg GR (2022) Lipogenesis inhibitors: therapeutic opportunities and challenges. Nat Rev Drug Discov 21:283\u2013305. https:\/\/doi.org\/10.1038\/s41573-021-00367-2","journal-title":"Nat Rev Drug Discov"},{"key":"4235_CR29","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/acs.chemrestox.1c00429","volume":"35","author":"M Bellouard","year":"2022","unstructured":"Bellouard M, Gasser M, Lenglet S et al (2022) Toxicity and metabolomic impact of cobalt, chromium, and nickel exposure on HepaRG hepatocytes. Chem Res Toxicol 35:807\u2013816. https:\/\/doi.org\/10.1021\/acs.chemrestox.1c00429","journal-title":"Chem Res Toxicol"},{"key":"4235_CR30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s42003-019-0675-0","volume":"2","author":"AY Belorusova","year":"2019","unstructured":"Belorusova AY, Evertsson E, Hovdal D et al (2019) Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands. Commun Biol 2:431. https:\/\/doi.org\/10.1038\/s42003-019-0675-0","journal-title":"Commun Biol"},{"issue":"4","key":"4235_CR31","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s00204-014-1197-7","volume":"88","author":"M Benet","year":"2014","unstructured":"Benet M, Moya M, Donato MT, Lahoz A, Herv\u00e1s D, Guzm\u00e1n C, G\u00f3mez-Lech\u00f3n MJ, Castell JV, Jover R (2014) A simple transcriptomic signature able to predict drug-induced hepatic steatosis. Arch Toxicol 88(4):967\u2013982. https:\/\/doi.org\/10.1007\/s00204-014-1197-7","journal-title":"Arch Toxicol"},{"key":"4235_CR32","doi-asserted-by":"crossref","unstructured":"Bennett MJ (2007) Assays of fatty acid \u03b2\u2010oxidation activity. In: Methods in Cell Biology. Elsevier, pp 179\u2013197","DOI":"10.1016\/S0091-679X(06)80009-9"},{"key":"4235_CR33","first-page":"335","volume":"116","author":"PD Berk","year":"2005","unstructured":"Berk PD, Zhou S, bradbury MW (2005) Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings. Trans Am Clin Climatol Assoc 116:335\u2013344","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"4235_CR34","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1016\/j.jmb.2013.05.010","volume":"425","author":"A Bernardes","year":"2013","unstructured":"Bernardes A, Souza PCT, Muniz JRC et al (2013) Molecular mechanism of peroxisome proliferator-activated receptor \u03b1 activation by WY14643: a new mode of ligand recognition and receptor stabilization. J Mol Biol 425:2878\u20132893. https:\/\/doi.org\/10.1016\/j.jmb.2013.05.010","journal-title":"J Mol Biol"},{"issue":"1","key":"4235_CR35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.toxlet.2015.03.009","volume":"235","author":"BD Bertuloso","year":"2015","unstructured":"Bertuloso BD, Podratz PL, Merlo E, de Ara\u00fajo JFP, Lima LCF, de Miguel EC, de Souza LN, Gava AL, de Oliveira M, Miranda-Alves L, Carneiro MTWD, Nogueira CR, Graceli JB (2015) Tributyltin chloride leads to adiposity and impairs metabolic functions in the rat liver and pancreas. Toxicol Lett 235(1):45\u201359. https:\/\/doi.org\/10.1016\/j.toxlet.2015.03.009","journal-title":"Toxicol Lett"},{"key":"4235_CR36","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1093\/toxsci\/kfh253","volume":"82","author":"MT Bility","year":"2004","unstructured":"Bility MT (2004) Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol Sci 82:170\u2013182. https:\/\/doi.org\/10.1093\/toxsci\/kfh253","journal-title":"Toxicol Sci"},{"issue":"8-9","key":"4235_CR37","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/S0399-8320(04)95062-2","volume":"28","author":"M Biour","year":"2004","unstructured":"Biour M, Ben Salem C, Chazouill\u00e8res O, Grang\u00e9 J-D, Serfati L, Poupon R (2004) H\u00e9patotoxicit\u00e9 des m\u00e9dicaments 14e mise \u00e0 jour du fichier bibliographique des atteintes h\u00e9patiques et des m\u00e9dicaments responsables. Gastroenterol Clin Biol 28(8\u20139):720\u2013759. https:\/\/doi.org\/10.1016\/S0399-8320(04)95062-2","journal-title":"Gastroenterol Clin Biol"},{"key":"4235_CR38","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1039\/C6MD00043F","volume":"7","author":"PN Black","year":"2016","unstructured":"Black PN, Ahowesso C, Montefusco D et al (2016) Fatty acid transport proteins: targeting FATP2 as a gatekeeper involved in the transport of exogenous fatty acids. MedChemComm 7:612\u2013622. https:\/\/doi.org\/10.1039\/C6MD00043F","journal-title":"MedChemComm"},{"key":"4235_CR39","doi-asserted-by":"publisher","unstructured":"Blum J, Br\u00fcll M, Hengstler J et al (2025) The long way from raw data to NAM-based information: Overview on data layers and processing steps. ALTEX 42:167\u2013180. https:\/\/doi.org\/10.14573\/altex.2412171","DOI":"10.14573\/altex.2412171"},{"key":"4235_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2020.101068","volume":"7","author":"J Boeckmans","year":"2020","unstructured":"Boeckmans J, Natale A, Rombaut M, Buyl K, Vanhaecke T, Rogiers V, Rodrigues RM, De Kock J (2020) Flow cytometric quantification of neutral lipids in a human skin stem cell-derived model of NASH. MethodsX 7:101068. https:\/\/doi.org\/10.1016\/j.mex.2020.101068","journal-title":"MethodsX"},{"key":"4235_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2025.102529","volume":"49","author":"A Borgne-Sanchez","year":"2025","unstructured":"Borgne-Sanchez A, Fromenty B (2025) Mitochondrial dysfunction in drug-induced hepatic steatosis: recent findings and current concept. Clin Res Hepatol Gastroenterol 49:102529. https:\/\/doi.org\/10.1016\/j.clinre.2025.102529","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"4235_CR42","doi-asserted-by":"publisher","first-page":"395","DOI":"10.14573\/altex.1912041","volume":"37","author":"P Bos","year":"2020","unstructured":"Bos P (2020) Towards an animal-free human health assessment: starting from the current regulatory needs. Altex 37:395\u2013408. https:\/\/doi.org\/10.14573\/altex.1912041","journal-title":"Altex"},{"key":"4235_CR43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.toxlet.2022.08.006","volume":"368","author":"T Brecklinghaus","year":"2022","unstructured":"Brecklinghaus T, Albrecht W, Duda J et al (2022) In vitro\/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay. Toxicol Lett 368:33\u201346. https:\/\/doi.org\/10.1016\/j.toxlet.2022.08.006","journal-title":"Toxicol Lett"},{"key":"4235_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/toxres\/tfac087","volume":"12","author":"S Brescia","year":"2023","unstructured":"Brescia S, Alexander-White C, Li H, Cayley A (2023) Risk assessment in the 21st century: where are we heading? Toxicol Res 12:1\u201311. https:\/\/doi.org\/10.1093\/toxres\/tfac087","journal-title":"Toxicol Res"},{"issue":"2","key":"4235_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021324","volume":"25","author":"K-B Bu","year":"2024","unstructured":"Bu K-B, Kim M, Shin MK, Lee S-H, Sung J-S (2024) Regulation of benzo[a]pyrene-induced hepatic lipid accumulation through CYP1B1-induced mTOR-mediated lipophagy. Int J Mol Sci 25(2):1324. https:\/\/doi.org\/10.3390\/ijms25021324","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4235_CR46","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4396403","volume":"2018","author":"S Bucher","year":"2018","unstructured":"Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, T\u00eate A, Sergent O, Lagadic-Gossmann D, Fromenty B (2018) Possible involvement of mitochondrial dysfunction and oxidative stress in a cellular model of NAFLD progression induced by benzo[a]pyrene\/ethanol coexposure. Oxid Med Cell Longev 2018(1):4396403. https:\/\/doi.org\/10.1155\/2018\/4396403","journal-title":"Oxid Med Cell Longev"},{"issue":"9","key":"4235_CR47","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/jat.3165","volume":"35","author":"N Burden","year":"2015","unstructured":"Burden N, Sewell F, Andersen ME, Boobis A, Chipman JK, Cronin MTD, Hutchinson TH, Kimber I, Whelan M (2015) Adverse outcome pathways can drive non-animal approaches for safety assessment. J Appl Toxicol 35(9):971\u2013975. https:\/\/doi.org\/10.1002\/jat.3165","journal-title":"J Appl Toxicol"},{"key":"4235_CR48","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1007\/s00204-020-02835-x","volume":"94","author":"F Caiment","year":"2020","unstructured":"Caiment F, Wolters J, Smit E et al (2020) Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C\/EBP\u03b1-controlled gene expression. Arch Toxicol 94:3463\u20133473. https:\/\/doi.org\/10.1007\/s00204-020-02835-x","journal-title":"Arch Toxicol"},{"key":"4235_CR49","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ejmech.2013.02.015","volume":"63","author":"A Carrieri","year":"2013","unstructured":"Carrieri A, Giudici M, Parente M, De Rosas M, Piemontese L, Fracchiolla G, Laghezza A, Tortorella P, Carbonara G, Lavecchia A, Gilardi F, Crestani M, Loiodice F (2013) Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors \u03b1\/\u03b3 agonists. Eur J Med Chem 63:321\u2013332. https:\/\/doi.org\/10.1016\/j.ejmech.2013.02.015","journal-title":"Eur J Med Chem"},{"key":"4235_CR50","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1093\/jn\/134.6.1340","volume":"134","author":"A Casaschi","year":"2004","unstructured":"Casaschi A, Maiyoh GK, Rubio BK et al (2004) The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells. J Nutr 134:1340\u20131346. https:\/\/doi.org\/10.1093\/jn\/134.6.1340","journal-title":"J Nutr"},{"issue":"9","key":"4235_CR51","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.1016\/j.bmc.2008.03.043","volume":"16","author":"A Casimiro-Garcia","year":"2008","unstructured":"Casimiro-Garcia A, Bigge CF, Davis JA, Padalino T, Pulaski J, Ohren JF, McConnell P, Kane CD, Royer LJ, Stevens KA, Auerbach BJ, Collard WT, McGregor C, Fakhoury SA, Schaum RP, Zhou H (2008) Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPAR\u03b1\/\u03b3 dual agonists, and X-ray crystallographic studies. Bioorg Med Chem 16(9):4883\u20134907. https:\/\/doi.org\/10.1016\/j.bmc.2008.03.043","journal-title":"Bioorg Med Chem"},{"key":"4235_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096580","volume":"9","author":"N Cedergreen","year":"2014","unstructured":"Cedergreen N (2014) Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology. PLoS ONE 9:e96580. https:\/\/doi.org\/10.1371\/journal.pone.0096580","journal-title":"PLoS ONE"},{"key":"4235_CR53","doi-asserted-by":"crossref","unstructured":"\u00c7etin Y (2025) Assessing the toxic potential of new entities: the role of cytotoxicity assays. In: Erkeko\u011flu P (ed) Biochemistry. IntechOpen","DOI":"10.5772\/intechopen.1008309"},{"key":"4235_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/9576503","volume":"2016","author":"R Chang","year":"2016","unstructured":"Chang R, Chou M-C, Hung L-Y et al (2016) Study of valproic acid-enhanced hepatocyte steatosis. Biomed Res Int 2016:1\u201311. https:\/\/doi.org\/10.1155\/2016\/9576503","journal-title":"Biomed Res Int"},{"key":"4235_CR55","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.14218\/JCTH.2023.00334","volume":"11","author":"Z Changizi","year":"2023","unstructured":"Changizi Z, Kajbaf F, Moslehi A (2023) An overview of the role of peroxisome proliferator-activated receptors in liver diseases. J Clin Transl Hepatol 11:1542\u20131552. https:\/\/doi.org\/10.14218\/JCTH.2023.00334","journal-title":"J Clin Transl Hepatol"},{"key":"4235_CR56","doi-asserted-by":"publisher","first-page":"11245","DOI":"10.1073\/pnas.0404297101","volume":"101","author":"G Chen","year":"2004","unstructured":"Chen G, Liang G, Ou J et al (2004) Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A 101:11245\u201311250. https:\/\/doi.org\/10.1073\/pnas.0404297101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"4235_CR57","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/13543784.2019.1657825","volume":"28","author":"L Chen","year":"2019","unstructured":"Chen L, Duan Y, Wei H, Ning H, Bi C, Zhao Y, Qin Y, Li Y (2019) Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1\/2 inhibitors. Expert Opin Investig Drugs 28(10):917\u2013930. https:\/\/doi.org\/10.1080\/13543784.2019.1657825","journal-title":"Expert Opin Investig Drugs"},{"key":"4235_CR58","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jtbi.2011.08.009","volume":"290","author":"F Cheng","year":"2011","unstructured":"Cheng F, Theodorescu D, Schulman IG, Lee JK (2011) In vitro transcriptomic prediction of hepatotoxicity for early drug discovery. J Theor Biol 290:27\u201336. https:\/\/doi.org\/10.1016\/j.jtbi.2011.08.009","journal-title":"J Theor Biol"},{"key":"4235_CR59","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3389","author":"C Cheng","year":"2018","unstructured":"Cheng C, Deng X, Xu K (2018) Increased expression of sterol regulatory element binding protein-2 alleviates autophagic dysfunction in NAFLD. Int J Mol Med. https:\/\/doi.org\/10.3892\/ijmm.2018.3389","journal-title":"Int J Mol Med"},{"key":"4235_CR60","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.regpep.2011.09.003","volume":"173","author":"CS Chiariello","year":"2012","unstructured":"Chiariello CS, LaComb JF, Bahou WF, Schmidt VA (2012) Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake. Regul Pept 173:36\u201346. https:\/\/doi.org\/10.1016\/j.regpep.2011.09.003","journal-title":"Regul Pept"},{"key":"4235_CR61","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.tem.2011.04.007","volume":"22","author":"SH Choi","year":"2011","unstructured":"Choi SH, Ginsberg HN (2011) Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. Trends Endocrinol Metab 22:353\u2013363. https:\/\/doi.org\/10.1016\/j.tem.2011.04.007","journal-title":"Trends Endocrinol Metab"},{"key":"4235_CR62","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/toxsci\/kfv049","volume":"145","author":"Y-J Choi","year":"2015","unstructured":"Choi Y-J, Lee C-H, Lee K-Y et al (2015) Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice. Toxicol Sci 145:273\u2013282. https:\/\/doi.org\/10.1093\/toxsci\/kfv049","journal-title":"Toxicol Sci"},{"issue":"23","key":"4235_CR63","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.1016\/j.bmcl.2009.10.012","volume":"19","author":"T Chonan","year":"2009","unstructured":"Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A (2009) 4-piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett 19(23):6645\u20136648. https:\/\/doi.org\/10.1016\/j.bmcl.2009.10.012","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"4235_CR64","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1016\/j.cmet.2021.06.012","volume":"33","author":"BL Clifford","year":"2021","unstructured":"Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlstr\u00f6m A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall H-U, Tarling EJ, Edwards PA, de Aguiar Vallim TQ (2021) FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab 33(8):1671-1684.e4. https:\/\/doi.org\/10.1016\/j.cmet.2021.06.012","journal-title":"Cell Metab"},{"issue":"4","key":"4235_CR65","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/ieam.4153","volume":"15","author":"K Coady","year":"2019","unstructured":"Coady K, Browne P, Embry M, Hill T, Leinala E, Steeger T, Ma\u015blankiewicz L, Hutchinson T (2019) When are adverse outcome pathways and associated assays \u201cfit for purpose\u201d for regulatory decision\u2010making and management of chemicals? Integr Environ Assess Manag 15(4):633\u2013647. https:\/\/doi.org\/10.1002\/ieam.4153","journal-title":"Integr Environ Assess Manag"},{"issue":"10","key":"4235_CR66","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1021\/jm0255116","volume":"45","author":"JL Collins","year":"2002","unstructured":"Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, Willson TM (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 45(10):1963\u20131966. https:\/\/doi.org\/10.1021\/jm0255116","journal-title":"J Med Chem"},{"issue":"16","key":"4235_CR67","doi-asserted-by":"publisher","first-page":"5401","DOI":"10.1021\/jacs.7b12817","volume":"140","author":"M Collot","year":"2018","unstructured":"Collot M, Fam TK, Ashokkumar P, Faklaris O, Galli T, Danglot L, Klymchenko AS (2018) Ultrabright and fluorogenic probes for multicolor imaging and tracking of lipid droplets in cells and tissues. J Am Chem Soc 140(16):5401\u20135411. https:\/\/doi.org\/10.1021\/jacs.7b12817","journal-title":"J Am Chem Soc"},{"key":"4235_CR68","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1177\/026119290703500408","volume":"35","author":"R Combes","year":"2007","unstructured":"Combes R (2007) Developing, validating and using test batteries and tiered (hierarchical) testing schemes. Altern Lab Anim 35:375\u2013378. https:\/\/doi.org\/10.1177\/026119290703500408","journal-title":"Altern Lab Anim"},{"issue":"1","key":"4235_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31025-0","volume":"8","author":"JM Correnti","year":"2018","unstructured":"Correnti JM, Gottshall L, Lin A, Williams B, Oranu A, Beck J, Chen J, Bennett MJ, Carr RM (2018) Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells. Sci Rep 8(1):12923. https:\/\/doi.org\/10.1038\/s41598-018-31025-0","journal-title":"Sci Rep"},{"key":"4235_CR70","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.comtox.2019.01.007","volume":"10","author":"JC Corton","year":"2019","unstructured":"Corton JC (2019) Frequent modulation of the sterol regulatory element binding protein (SREBP) by chemical exposure in the livers of rats. Comput Toxicol 10:113\u2013129. https:\/\/doi.org\/10.1016\/j.comtox.2019.01.007","journal-title":"Comput Toxicol"},{"key":"4235_CR71","doi-asserted-by":"publisher","first-page":"573","DOI":"10.2217\/pgs.10.37","volume":"11","author":"Y Cui","year":"2010","unstructured":"Cui Y, Paules RS (2010) Use of transcriptomics in understanding mechanisms of drug-induced toxicity. Pharmacogenomics 11:573\u2013585. https:\/\/doi.org\/10.2217\/pgs.10.37","journal-title":"Pharmacogenomics"},{"key":"4235_CR72","first-page":"95","volume":"2","author":"W Cui","year":"2010","unstructured":"Cui W, Chen SL, Hu K-Q (2010) Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells. Am J Transl Res 2:95\u2013104","journal-title":"Am J Transl Res"},{"issue":"3","key":"4235_CR73","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.molmet.2015.12.005","volume":"5","author":"S Daemen","year":"2016","unstructured":"Daemen S, Van Zandvoort MAM, Parekh SH, Hesselink MKC (2016) Microscopy tools for the investigation of intracellular lipid storage and dynamics. Mol Metab 5(3):153\u2013163. https:\/\/doi.org\/10.1016\/j.molmet.2015.12.005","journal-title":"Mol Metab"},{"key":"4235_CR74","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tox.2016.12.007","volume":"378","author":"KP Das","year":"2017","unstructured":"Das KP, Wood CR, Lin MT et al (2017) Perfluoroalkyl acids-induced liver steatosis: effects on genes controlling lipid homeostasis. Toxicology 378:37\u201352. https:\/\/doi.org\/10.1016\/j.tox.2016.12.007","journal-title":"Toxicology"},{"key":"4235_CR75","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.3390\/cells12081201","volume":"12","author":"Y Dauwe","year":"2023","unstructured":"Dauwe Y, Mary L, Oliviero F et al (2023) Steatosis and metabolic disorders associated with synergistic activation of the CAR\/RXR heterodimer by pesticides. Cells 12:1201. https:\/\/doi.org\/10.3390\/cells12081201","journal-title":"Cells"},{"key":"4235_CR76","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3390\/cells13110940","volume":"13","author":"Y Dauwe","year":"2024","unstructured":"Dauwe Y, Mary L, Oliviero F et al (2024) Synergistic steatosis induction in mice: exploring the interactions and underlying mechanisms between PFOA and tributyltin. Cells 13:940. https:\/\/doi.org\/10.3390\/cells13110940","journal-title":"Cells"},{"key":"4235_CR77","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1016\/j.jhep.2023.07.031","volume":"80","author":"A De","year":"2023","unstructured":"De A, Bhagat N, Mehta M et al (2023) Metabolic dysfunction-associated steatotic liver disease (MASLD) definition is better than MAFLD criteria for lean patients with NAFLD. J Hepatol 80:e61\u2013e62. https:\/\/doi.org\/10.1016\/j.jhep.2023.07.031","journal-title":"J Hepatol"},{"issue":"8","key":"4235_CR78","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/labinvest.3700590","volume":"87","author":"A De Gottardi","year":"2007","unstructured":"De Gottardi A, Vinciguerra M, Sgroi A, Moukil M, Ravier-Dall\u2019Antonia F, Pazienza V, Pugnale P, Foti M, Hadengue A (2007) Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes. Lab Invest 87(8):792\u2013806. https:\/\/doi.org\/10.1038\/labinvest.3700590","journal-title":"Lab Invest"},{"key":"4235_CR79","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-4939-2074-7_8","volume":"1250","author":"J De Kock","year":"2015","unstructured":"De Kock J, Rodrigues RM, Buyl K, Rogiers V (2015) Human skin-derived precursor cells: isolation, expansion, and hepatic differentiation. Methods Mol Biol 1250:113\u2013122. https:\/\/doi.org\/10.1007\/978-1-4939-2074-7_8","journal-title":"Methods Mol Biol"},{"key":"4235_CR80","doi-asserted-by":"publisher","first-page":"8089","DOI":"10.1038\/ncomms9089","volume":"6","author":"V Delfosse","year":"2015","unstructured":"Delfosse V, Dendele B, Huet T et al (2015) Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Nat Commun 6:8089. https:\/\/doi.org\/10.1038\/ncomms9089","journal-title":"Nat Commun"},{"issue":"7","key":"4235_CR82","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.micron.2008.01.001","volume":"39","author":"G Diaz","year":"2008","unstructured":"Diaz G, Melis M, Batetta B, Angius F, Falchi AM (2008) Hydrophobic characterization of intracellular lipids in situ by Nile Red red\/yellow emission ratio. Micron 39(7):819\u2013824. https:\/\/doi.org\/10.1016\/j.micron.2008.01.001","journal-title":"Micron"},{"key":"4235_CR83","doi-asserted-by":"publisher","unstructured":"Ding H, Yu J-H, Ge G et al (2021) RASAL2 deficiency attenuates hepatic steatosis by promoting hepatic VLDL secretion via the AKT\/TET1\/MTTP axis. J Clin Transl Hepatol 11:261\u2013272. https:\/\/doi.org\/10.14218\/JCTH.2022.00042","DOI":"10.14218\/JCTH.2022.00042"},{"issue":"3","key":"4235_CR84","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.cmet.2018.06.001","volume":"28","author":"AS Divakaruni","year":"2018","unstructured":"Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN (2018) Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis. Cell Metab 28(3):490-503.e7. https:\/\/doi.org\/10.1016\/j.cmet.2018.06.001","journal-title":"Cell Metab"},{"issue":"3","key":"4235_CR85","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cbi.2009.07.019","volume":"181","author":"MT Donato","year":"2009","unstructured":"Donato MT, Mart\u00ednez-Romero A, Jim\u00e9nez N, Negro A, Herrera G, Castell JV, O\u2019Connor J-E, G\u00f3mez-Lech\u00f3n MJ (2009) Cytometric analysis for drug-induced steatosis in HepG2 cells. Chem Biol Interact 181(3):417\u2013423. https:\/\/doi.org\/10.1016\/j.cbi.2009.07.019","journal-title":"Chem Biol Interact"},{"key":"4235_CR86","doi-asserted-by":"publisher","first-page":"11428","DOI":"10.3390\/ijms231911428","volume":"23","author":"MT Donato","year":"2022","unstructured":"Donato MT, Gallego-Ferrer G, Tolosa L (2022) In vitro models for studying chronic drug-induced liver injury. Int J Mol Sci 23:11428. https:\/\/doi.org\/10.3390\/ijms231911428","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4235_CR87","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/s1097-2765(03)00104-7","volume":"11","author":"M Downes","year":"2003","unstructured":"Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer J-L, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JGA, Noel JP, Nicolaou KC, Evans RM (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell 11(4):1079\u20131092. https:\/\/doi.org\/10.1016\/s1097-2765(03)00104-7","journal-title":"Mol Cell"},{"key":"4235_CR88","doi-asserted-by":"publisher","first-page":"2179334","DOI":"10.1080\/21623945.2023.2179334","volume":"12","author":"J Du","year":"2023","unstructured":"Du J, Zhao L, Kang Q et al (2023) An optimized method for Oil Red O staining with the salicylic acid ethanol solution. Adipocyte 12:2179334. https:\/\/doi.org\/10.1080\/21623945.2023.2179334","journal-title":"Adipocyte"},{"key":"4235_CR89","doi-asserted-by":"crossref","unstructured":"Dubikovskaya E, Chudnovskiy R, Karateev G et al (2014) Measurement of long-chain fatty acid uptake into adipocytes. In: Methods in Enzymology. Elsevier, pp 107\u2013134","DOI":"10.1016\/B978-0-12-800280-3.00007-4"},{"key":"4235_CR90","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.3748\/wjg.14.4120","volume":"14","author":"A-R El-Zayadi","year":"2008","unstructured":"El-Zayadi A-R (2008) Hepatic steatosis: a benign disease or a silent killer. World J Gastroenterol 14:4120. https:\/\/doi.org\/10.3748\/wjg.14.4120","journal-title":"World J Gastroenterol"},{"key":"4235_CR91","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0304-4165(02)00275-1","volume":"1573","author":"B Elzinga","year":"2002","unstructured":"Elzinga B (2002) The role of transhepatic bile salt flux in the control of hepatic secretion of triacylglycerol-rich lipoproteins in vivo in rodents. Biochim Biophys Acta Gen Subj 1573:9\u201320. https:\/\/doi.org\/10.1016\/S0304-4165(02)00275-1","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"4235_CR92","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.phrs.2010.07.004","volume":"62","author":"MC Ernst","year":"2010","unstructured":"Ernst MC, Sinal CJ, Pollak PT (2010) Influence of peroxisome proliferator-activated receptor-alpha (PPAR\u03b1) activity on adverse effects associated with amiodarone exposure in mice. Pharmacol Res 62:408\u2013415. https:\/\/doi.org\/10.1016\/j.phrs.2010.07.004","journal-title":"Pharmacol Res"},{"key":"4235_CR93","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2022.103967","volume":"95","author":"D Ezhilarasan","year":"2022","unstructured":"Ezhilarasan D, Mani U (2022) Valproic acid induced liver injury: an insight into molecular toxicological mechanism. Environ Toxicol Pharmacol 95:103967. https:\/\/doi.org\/10.1016\/j.etap.2022.103967","journal-title":"Environ Toxicol Pharmacol"},{"key":"4235_CR94","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.3390\/ma11091768","volume":"11","author":"TK Fam","year":"2018","unstructured":"Fam TK, Klymchenko AS, Collot M (2018) Recent advances in fluorescent probes for lipid droplets. Materials 11:1768. https:\/\/doi.org\/10.3390\/ma11091768","journal-title":"Materials"},{"key":"4235_CR95","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.970292","volume":"13","author":"C Fang","year":"2022","unstructured":"Fang C, Pan J, Qu N, Lei Y, Han J, Zhang J, Han D (2022) The AMPK pathway in fatty liver disease. Front Physiol 13:970292. https:\/\/doi.org\/10.3389\/fphys.2022.970292","journal-title":"Front Physiol"},{"key":"4235_CR96","unstructured":"FDA (2025) Roadmap to reducing animal testing in preclinical safety studies"},{"key":"4235_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114880","volume":"265","author":"D Feng","year":"2020","unstructured":"Feng D, Zhang H, Jiang X, Zou J, Li Q, Mai H, Su D, Ling W, Feng X (2020) Bisphenol A exposure induces gut microbiota dysbiosis and consequent activation of gut-liver axis leading to hepatic steatosis in CD-1 mice. Environ Pollut 265:114880. https:\/\/doi.org\/10.1016\/j.envpol.2020.114880","journal-title":"Environ Pollut"},{"key":"4235_CR98","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/toxres\/tfaa011","volume":"9","author":"I Fischer","year":"2020","unstructured":"Fischer I, Milton C, Wallace H (2020) Toxicity testing is evolving! Toxicol Res 9:67\u201380. https:\/\/doi.org\/10.1093\/toxres\/tfaa011","journal-title":"Toxicol Res"},{"key":"4235_CR99","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497\u2013509. https:\/\/doi.org\/10.1016\/S0021-9258(18)64849-5","journal-title":"J Biol Chem"},{"issue":"6","key":"4235_CR100","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1016\/j.bmc.2012.01.025","volume":"20","author":"G Fracchiolla","year":"2012","unstructured":"Fracchiolla G, Laghezza A, Piemontese L, Parente M, Lavecchia A, Pochetti G, Montanari R, Giovanni CD, Carbonara G, Tortorella P, Novellino E, Loiodice F (2012) Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors \u03b1\/\u03b3 dual agonists. Bioorg Med Chem 20(6):2141\u20132151. https:\/\/doi.org\/10.1016\/j.bmc.2012.01.025","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"4235_CR101","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jmb.2010.04.005","volume":"399","author":"X Fradera","year":"2010","unstructured":"Fradera X, Vu D, Nimz O, Skene R, Hosfield D, Wynands R, Cooke AJ, Hauns\u00f8 A, King A, Bennett DJ, McGuire R, Uitdehaag JCM (2010) X-ray structures of the LXR\u03b1 LBD in its homodimeric form and implications for heterodimer signaling. J Mol Biol 399(1):120\u2013132. https:\/\/doi.org\/10.1016\/j.jmb.2010.04.005","journal-title":"J Mol Biol"},{"key":"4235_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.115009","volume":"398","author":"ME Franco","year":"2020","unstructured":"Franco ME, Fernandez-Luna MT, Ramirez AJ, Lavado R (2020) Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens. Toxicol Appl Pharmacol 398:115009. https:\/\/doi.org\/10.1016\/j.taap.2020.115009","journal-title":"Toxicol Appl Pharmacol"},{"key":"4235_CR103","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.livres.2019.06.001","volume":"3","author":"B Fromenty","year":"2019","unstructured":"Fromenty B (2019) Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis. Liver Res 3:157\u2013169. https:\/\/doi.org\/10.1016\/j.livres.2019.06.001","journal-title":"Liver Res"},{"issue":"8","key":"4235_CR104","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.fitote.2011.08.019","volume":"82","author":"Q Fu","year":"2011","unstructured":"Fu Q, Huang X, Shu B, Xue M, Zhang P, Wang T, Liu Li, Jiang Z, Zhang L (2011) Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury. Fitoterapia 82(8):1241\u20131248. https:\/\/doi.org\/10.1016\/j.fitote.2011.08.019","journal-title":"Fitoterapia"},{"key":"4235_CR105","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.1038\/s41467-021-23958-4","volume":"12","author":"X Fu","year":"2021","unstructured":"Fu X, Deja S, Fletcher JA et al (2021) Measurement of lipogenic flux by deuterium resolved mass spectrometry. Nat Commun 12:3756. https:\/\/doi.org\/10.1038\/s41467-021-23958-4","journal-title":"Nat Commun"},{"issue":"19","key":"4235_CR106","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1016\/j.chroma.2010.11.066","volume":"1218","author":"B Fuchs","year":"2011","unstructured":"Fuchs B, S\u00fc\u00df R, Teuber K, Eibisch M, Schiller J (2011) Lipid analysis by thin-layer chromatography\u2014a review of the current state. J Chromatogr A 1218(19):2754\u20132774. https:\/\/doi.org\/10.1016\/j.chroma.2010.11.066","journal-title":"J Chromatogr A"},{"key":"4235_CR107","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/jat.1420","volume":"29","author":"H Fujimura","year":"2009","unstructured":"Fujimura H, Murakami N, Kurabe M, Toriumi W (2009) In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis. J Appl Toxicol 29:356\u2013363. https:\/\/doi.org\/10.1002\/jat.1420","journal-title":"J Appl Toxicol"},{"issue":"4","key":"4235_CR108","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1194\/jlr.M800480-JLR200","volume":"50","author":"MP Gaidhu","year":"2009","unstructured":"Gaidhu MP, Fediuc S, Anthony NM, So M, Mirpourian M, Perry RLS, Ceddia RB (2009) Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL. J Lipid Res 50(4):704\u2013715. https:\/\/doi.org\/10.1194\/jlr.M800480-JLR200","journal-title":"J Lipid Res"},{"key":"4235_CR109","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3390\/antiox9100980","volume":"9","author":"M Galicia-Moreno","year":"2020","unstructured":"Galicia-Moreno M, Lucano-Landeros S, Monroy-Ramirez HC et al (2020) Roles of Nrf2 in liver diseases: molecular, pharmacological, and epigenetic aspects. Antioxidants 9:980. https:\/\/doi.org\/10.3390\/antiox9100980","journal-title":"Antioxidants"},{"issue":"4","key":"4235_CR110","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040479","volume":"17","author":"R Gambino","year":"2016","unstructured":"Gambino R, Bugianesi E, Rosso C, Mezzabotta L, Pinach S, Alemanno N, Saba F, Cassader M (2016) Different serum free fatty acid profiles in NAFLD subjects and healthy controls after oral fat load. Int J Mol Sci 17(4):479. https:\/\/doi.org\/10.3390\/ijms17040479","journal-title":"Int J Mol Sci"},{"key":"4235_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2019.100989","volume":"75","author":"M Gao","year":"2019","unstructured":"Gao M, Huang X, Song B-L, Yang H (2019) The biogenesis of lipid droplets: lipids take center stage. Prog Lipid Res 75:100989. https:\/\/doi.org\/10.1016\/j.plipres.2019.100989","journal-title":"Prog Lipid Res"},{"key":"4235_CR112","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1042\/bst0320059","volume":"32","author":"GF Gibbons","year":"2004","unstructured":"Gibbons GF, Wiggins D, Brown A-M, Hebbachi A-M (2004) Synthesis and function of hepatic very-low-density lipoprotein. Biochem Soc Trans 32:59\u201364. https:\/\/doi.org\/10.1042\/bst0320059","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"4235_CR113","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.yexmp.2014.12.006","volume":"98","author":"PJ Giraudi","year":"2015","unstructured":"Giraudi PJ, Barbero Becerra VJ, Marin V, Chavez-Tapia NC, Tiribelli C, Rosso N (2015) The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation. Exp Mol Pathol 98(1):85\u201392. https:\/\/doi.org\/10.1016\/j.yexmp.2014.12.006","journal-title":"Exp Mol Pathol"},{"key":"4235_CR114","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nrgastro.2017.32","volume":"14","author":"NL Gluchowski","year":"2017","unstructured":"Gluchowski NL, Becuwe M, Walther TC, Farese RV (2017) Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol 14:343\u2013355. https:\/\/doi.org\/10.1038\/nrgastro.2017.32","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"4235_CR115","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040810","volume":"18","author":"K Goda","year":"2017","unstructured":"Goda K, Kobayashi A, Takahashi A, Takahashi T, Saito K, Maekawa K, Saito Y, Sugai S (2017) Evaluation of the potential risk of drugs to induce hepatotoxicity in human\u2014relationships between hepatic steatosis observed in non-clinical toxicity study and hepatotoxicity in humans. Int J Mol Sci 18(4):810. https:\/\/doi.org\/10.3390\/ijms18040810","journal-title":"Int J Mol Sci"},{"key":"4235_CR116","doi-asserted-by":"publisher","first-page":"292","DOI":"10.2174\/1389200033489424","volume":"4","author":"M Gomez-Lechon","year":"2003","unstructured":"Gomez-Lechon M, Donato M, Castell J, Jover R (2003) Human hepatocytes as a tool for studying toxicity and drug metabolism. Curr Drug Metab 4:292\u2013312. https:\/\/doi.org\/10.2174\/1389200033489424","journal-title":"Curr Drug Metab"},{"key":"4235_CR117","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/j.tiv.2010.07.018","volume":"24","author":"MJ G\u00f3mez-Lech\u00f3n","year":"2010","unstructured":"G\u00f3mez-Lech\u00f3n MJ, Tolosa L, Castell JV, Donato MT (2010) Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project. Toxicol in Vitro 24:1879\u20131889. https:\/\/doi.org\/10.1016\/j.tiv.2010.07.018","journal-title":"Toxicol in Vitro"},{"key":"4235_CR118","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.atherosclerosissup.2015.02.005","volume":"18","author":"I Gouni-Berthold","year":"2015","unstructured":"Gouni-Berthold I, Berthold HK (2015) Mipomersen and lomitapide: two new drugs for the treatment of homozygous familial hypercholesterolemia. Atheroscler Suppl 18:28\u201334. https:\/\/doi.org\/10.1016\/j.atherosclerosissup.2015.02.005","journal-title":"Atheroscler Suppl"},{"issue":"14","key":"4235_CR119","doi-asserted-by":"publisher","first-page":"6237","DOI":"10.1021\/jacs.1c10836","volume":"144","author":"GF Grabner","year":"2022","unstructured":"Grabner GF, Guttenberger N, Mayer N, Migglautsch-Sulzer AK, Lembacher-Fadum C, Fawzy N, Bulfon D, Hofer P, Z\u00fcllig T, Hartig L, Kulminskaya N, Chalhoub G, Schratter M, Radner FPW, Preiss-Landl K, Masser S, Lass A, Zechner R, Gruber K, Oberer M, Breinbauer R, Zimmermann R (2022) Small-molecule inhibitors targeting lipolysis in human adipocytes. J Am Chem Soc 144(14):6237\u20136250. https:\/\/doi.org\/10.1021\/jacs.1c10836","journal-title":"J Am Chem Soc"},{"key":"4235_CR120","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/cells10051016","volume":"10","author":"JD Griffin","year":"2021","unstructured":"Griffin JD, Bejarano E, Wang X-D, Greenberg AS (2021) Integrated action of autophagy and adipose tissue triglyceride lipase ameliorates diet-induced hepatic steatosis in liver-specific PLIN2 knockout mice. Cells 10:1016. https:\/\/doi.org\/10.3390\/cells10051016","journal-title":"Cells"},{"key":"4235_CR121","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.chemosphere.2014.09.068","volume":"120","author":"KJ Groh","year":"2015","unstructured":"Groh KJ, Carvalho RN, Chipman JK, Denslow ND, Halder M, Murphy CA, Roelofs D, Rolaki A, Schirmer K, Watanabe KH (2015) Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. challenges and research needs in ecotoxicology. Chemosphere 120:764\u2013777. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.09.068","journal-title":"Chemosphere"},{"key":"4235_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113860","volume":"177","author":"D Gr\u00fcnig","year":"2020","unstructured":"Gr\u00fcnig D, Szabo L, Marbet M, Kr\u00e4henb\u00fchl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860. https:\/\/doi.org\/10.1016\/j.bcp.2020.113860","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"4235_CR123","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cbi.2006.12.003","volume":"168","author":"A Guillouzo","year":"2007","unstructured":"Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168(1):66\u201373. https:\/\/doi.org\/10.1016\/j.cbi.2006.12.003","journal-title":"Chem Biol Interact"},{"issue":"11","key":"4235_CR124","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1007\/s00204-020-02868-2","volume":"94","author":"E Gustafson","year":"2020","unstructured":"Gustafson E, Debruyne C, De Troyer O, Rogiers V, Vinken M, Vanhaecke T (2020) Screening of repeated dose toxicity data in safety evaluation reports of cosmetic ingredients issued by the Scientific Committee on Consumer Safety between 2009 and 2019. Arch Toxicol 94(11):3723\u20133735. https:\/\/doi.org\/10.1007\/s00204-020-02868-2","journal-title":"Arch Toxicol"},{"issue":"5","key":"4235_CR125","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.jhep.2018.12.038","volume":"70","author":"T Gwag","year":"2019","unstructured":"Gwag T, Meng Z, Sui Y, Helsley RN, Park S-H, Wang S, Greenberg RN, Zhou C (2019) Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis. J Hepatol 70(5):930\u2013940. https:\/\/doi.org\/10.1016\/j.jhep.2018.12.038","journal-title":"J Hepatol"},{"key":"4235_CR126","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/S0022-2275(20)39131-8","volume":"37","author":"M Haghpassand","year":"1996","unstructured":"Haghpassand M, Wilder D, Moberly JB (1996) Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2). J Lipid Res 37:1468\u20131480. https:\/\/doi.org\/10.1016\/S0022-2275(20)39131-8","journal-title":"J Lipid Res"},{"key":"4235_CR127","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ab.2006.04.046","volume":"356","author":"M Hampf","year":"2006","unstructured":"Hampf M, Gossen M (2006) A protocol for combined Photinus and Renilla luciferase quantification compatible with protein assays. Anal Biochem 356:94\u201399. https:\/\/doi.org\/10.1016\/j.ab.2006.04.046","journal-title":"Anal Biochem"},{"key":"4235_CR128","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1021\/acs.chemrestox.9b00058","volume":"32","author":"Z Hao","year":"2019","unstructured":"Hao Z, Zhang Z, Lu D et al (2019) Organophosphorus flame retardants impair intracellular lipid metabolic function in human hepatocellular cells. Chem Res Toxicol 32:1250\u20131258. https:\/\/doi.org\/10.1021\/acs.chemrestox.9b00058","journal-title":"Chem Res Toxicol"},{"key":"4235_CR129","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1504\/IJRAM.2017.082570","volume":"20","author":"T Hartung","year":"2017","unstructured":"Hartung T (2017) Evolution of toxicological science: the need for change. Int J Risk Assess Manag 20:21. https:\/\/doi.org\/10.1504\/IJRAM.2017.082570","journal-title":"Int J Risk Assess Manag"},{"key":"4235_CR130","doi-asserted-by":"publisher","first-page":"37099","DOI":"10.1074\/jbc.M304481200","volume":"278","author":"HJ Harwood","year":"2003","unstructured":"Harwood HJ, Petras SF, Shelly LD et al (2003) Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem 278:37099\u201337111. https:\/\/doi.org\/10.1074\/jbc.M304481200","journal-title":"J Biol Chem"},{"key":"4235_CR131","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1194\/jlr.RA119000294","volume":"61","author":"KB Hasbargen","year":"2020","unstructured":"Hasbargen KB, Shen W-J, Zhang Y et al (2020) Slc43a3 is a regulator of free fatty acid flux1. J Lipid Res 61:734\u2013745. https:\/\/doi.org\/10.1194\/jlr.RA119000294","journal-title":"J Lipid Res"},{"key":"4235_CR132","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","volume":"19","author":"S Herzig","year":"2018","unstructured":"Herzig S, Shaw RJ (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19:121\u2013135. https:\/\/doi.org\/10.1038\/nrm.2017.95","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4235_CR133","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.taap.2018.03.013","volume":"354","author":"EVS Hessel","year":"2018","unstructured":"Hessel EVS, Staal YCM, Piersma AH (2018) Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing. Toxicol Appl Pharmacol 354:136\u2013152. https:\/\/doi.org\/10.1016\/j.taap.2018.03.013","journal-title":"Toxicol Appl Pharmacol"},{"key":"4235_CR134","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1016\/j.biotechadv.2015.08.004","volume":"33","author":"S Heux","year":"2015","unstructured":"Heux S, Meynial-Salles I, O\u2019Donohue MJ, Dumon C (2015) White biotechnology: state of the art strategies for the development of biocatalysts for biorefining. Biotechnol Adv 33:1653\u20131670. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.08.004","journal-title":"Biotechnol Adv"},{"key":"4235_CR135","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41574-019-0256-9","volume":"15","author":"L Hodson","year":"2019","unstructured":"Hodson L, Gunn PJ (2019) The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state. Nat Rev Endocrinol 15:689\u2013700. https:\/\/doi.org\/10.1038\/s41574-019-0256-9","journal-title":"Nat Rev Endocrinol"},{"key":"4235_CR136","doi-asserted-by":"publisher","unstructured":"Hoffmann S, Aiassa E, Angrish M et al (2022) Application of evidence-based methods to construct mechanism-driven chemical assessment Frameworks. ALTEX 39:499\u2013518. https:\/\/doi.org\/10.14573\/altex.2202141","DOI":"10.14573\/altex.2202141"},{"key":"4235_CR137","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1161\/CIRCRESAHA.116.304637","volume":"116","author":"AJ Hooper","year":"2015","unstructured":"Hooper AJ, Burnett JR, Watts GF (2015) Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein. Circ Res 116:193\u2013205. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.304637","journal-title":"Circ Res"},{"key":"4235_CR138","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2025.102389","volume":"16","author":"Y-T Hsieh","year":"2025","unstructured":"Hsieh Y-T, Kang T-H, Hung H-Y et al (2025) Identification of a 2-phenoxychromone derivative as a novel inhibitor of lipid droplet formation in hepatocytes and adipocytes. Results Chem 16:102389. https:\/\/doi.org\/10.1016\/j.rechem.2025.102389","journal-title":"Results Chem"},{"key":"4235_CR139","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bmcl.2007.11.013","volume":"18","author":"B Hu","year":"2008","unstructured":"Hu B, Quinet E, Unwalla R et al (2008) Carboxylic acid based quinolines as liver X receptor modulators that have LXR\u03b2 receptor binding selectivity. Bioorg Med Chem Lett 18:54\u201359. https:\/\/doi.org\/10.1016\/j.bmcl.2007.11.013","journal-title":"Bioorg Med Chem Lett"},{"key":"4235_CR140","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s11655-016-2617-8","volume":"23","author":"C Hu","year":"2017","unstructured":"Hu C, Sun L, Yang Q et al (2017) Ginsenosides from stems and leaves of ginseng prevent ethanol-induced lipid accumulation in human L02 hepatocytes. Chin J Integr Med 23:438\u2013444. https:\/\/doi.org\/10.1007\/s11655-016-2617-8","journal-title":"Chin J Integr Med"},{"issue":"8","key":"4235_CR141","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.jsps.2018.07.006","volume":"26","author":"W-C Huang","year":"2018","unstructured":"Huang W-C, Chen Y-L, Liu H-C, Wu S-J, Liou C-J (2018) Ginkgolide C reduced oleic acid-induced lipid accumulation in HepG2 cells. Saudi Pharm J 26(8):1178\u20131184. https:\/\/doi.org\/10.1016\/j.jsps.2018.07.006","journal-title":"Saudi Pharm J"},{"key":"4235_CR142","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","volume":"74","author":"CH Hurst","year":"2003","unstructured":"Hurst CH, Waxman DJ (2003) Activation of PPAR and PPAR by environmental phthalate monoesters. Toxicol Sci 74:297\u2013308. https:\/\/doi.org\/10.1093\/toxsci\/kfg145","journal-title":"Toxicol Sci"},{"key":"4235_CR143","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107842","volume":"9","author":"H Impheng","year":"2014","unstructured":"Impheng H, Pongcharoen S, Richert L et al (2014) The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. PLoS ONE 9:e107842. https:\/\/doi.org\/10.1371\/journal.pone.0107842","journal-title":"PLoS ONE"},{"key":"4235_CR144","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2022.880818","volume":"4","author":"MN Jacobs","year":"2022","unstructured":"Jacobs MN, Kubickova B, Boshoff E (2022) Candidate proficiency test chemicals to address industrial chemical applicability domains for in vitro human cytochrome P450 enzyme induction. Front Toxicol 4:880818. https:\/\/doi.org\/10.3389\/ftox.2022.880818","journal-title":"Front Toxicol"},{"key":"4235_CR145","doi-asserted-by":"publisher","first-page":"5440","DOI":"10.1039\/C7SC01400G","volume":"8","author":"M Jiang","year":"2017","unstructured":"Jiang M, Gu X, Lam JWY et al (2017) Two-photon AIE bio-probe with large Stokes shift for specific imaging of lipid droplets. Chem Sci 8:5440\u20135446. https:\/\/doi.org\/10.1039\/C7SC01400G","journal-title":"Chem Sci"},{"issue":"1","key":"4235_CR146","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49224-x","volume":"15","author":"SM Johnson","year":"2024","unstructured":"Johnson SM, Bao H, McMahon CE, Chen Y, Burr SD, Anderson AM, Madeyski-Bengtson K, Lind\u00e9n D, Han X, Liu J (2024) PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein. Nat Commun 15(1):4847. https:\/\/doi.org\/10.1038\/s41467-024-49224-x","journal-title":"Nat Commun"},{"issue":"6","key":"4235_CR147","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2025.167888","volume":"1871","author":"EK Johnston","year":"2025","unstructured":"Johnston EK, Fang Z, Soto-Guti\u00e9rrez A, Taner CB, Cook KE, Yang L, Abbott RD (2025) Engineering a three-dimensional liver steatosis model. Biochimica Et Biophysica Acta (BBA) - Mol Basis Disease 1871(6):167888. https:\/\/doi.org\/10.1016\/j.bbadis.2025.167888","journal-title":"Biochimica Et Biophysica Acta (BBA) - Mol Basis Disease"},{"key":"4235_CR148","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.bcp.2010.12.014","volume":"81","author":"DB Jump","year":"2011","unstructured":"Jump DB, Torres-Gonzalez M, Olson LK (2011) Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol 81:649\u2013660. https:\/\/doi.org\/10.1016\/j.bcp.2010.12.014","journal-title":"Biochem Pharmacol"},{"key":"4235_CR149","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.chembiol.2009.07.007","volume":"16","author":"S Kamisuki","year":"2009","unstructured":"Kamisuki S, Mao Q, Abu-Elheiga L et al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol 16:882\u2013892. https:\/\/doi.org\/10.1016\/j.chembiol.2009.07.007","journal-title":"Chem Biol"},{"key":"4235_CR150","doi-asserted-by":"publisher","first-page":"35775","DOI":"10.1074\/jbc.M403630200","volume":"279","author":"JP Kampf","year":"2004","unstructured":"Kampf JP, Kleinfeld AM (2004) Fatty acid transport in adipocytes monitored by imaging intracellular free fatty acid levels. J Biol Chem 279:35775\u201335780. https:\/\/doi.org\/10.1074\/jbc.M403630200","journal-title":"J Biol Chem"},{"key":"4235_CR151","doi-asserted-by":"publisher","first-page":"E1207","DOI":"10.1152\/ajpendo.00259.2007","volume":"293","author":"JP Kampf","year":"2007","unstructured":"Kampf JP, Parmley D, Kleinfeld AM (2007) Free fatty acid transport across adipocytes is mediated by an unknown membrane protein pump. Am J Physiol Endocrinol Metab 293:E1207\u2013E1214. https:\/\/doi.org\/10.1152\/ajpendo.00259.2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"4235_CR152","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.abb.2010.09.001","volume":"504","author":"Y Kawano","year":"2010","unstructured":"Kawano Y, Nishiumi S, Tanaka S, Nobutani K, Miki A, Yano Y, Seo Y, Kutsumi H, Ashida H, Azuma T, Yoshida M (2010) Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport. Arch Biochem Biophys 504(2):221\u2013227. https:\/\/doi.org\/10.1016\/j.abb.2010.09.001","journal-title":"Arch Biochem Biophys"},{"key":"4235_CR153","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3390\/biom8040174","volume":"8","author":"S Khoury","year":"2018","unstructured":"Khoury S, Canlet C, Lacroix MZ et al (2018) Quantification of lipids: model, reality, and compromise. Biomolecules 8:174. https:\/\/doi.org\/10.3390\/biom8040174","journal-title":"Biomolecules"},{"key":"4235_CR154","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1039\/c7tx00326a","volume":"7","author":"JE Klaunig","year":"2018","unstructured":"Klaunig JE, Li X, Wang Z (2018) Role of xenobiotics in the induction and progression of fatty liver disease. Toxicol Res 7:664\u2013680. https:\/\/doi.org\/10.1039\/c7tx00326a","journal-title":"Toxicol Res"},{"key":"4235_CR155","doi-asserted-by":"publisher","first-page":"6113","DOI":"10.3390\/ijms21176113","volume":"21","author":"A Kloska","year":"2020","unstructured":"Kloska A, W\u0119sierska M, Malinowska M et al (2020) Lipophagy and lipolysis status in lipid storage and lipid metabolism diseases. Int J Mol Sci 21:6113. https:\/\/doi.org\/10.3390\/ijms21176113","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4235_CR156","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1093\/toxsci\/kfy026","volume":"163","author":"C Knebel","year":"2018","unstructured":"Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, P\u00fcschel GP, Zanger UM, S\u00fcssmuth R, Lampen A, Marx-Stoelting P, Braeuning A (2018) Unexpected effects of propiconazole, tebuconazole, and their mixture on the receptors CAR and PXR in human liver cells. Toxicol Sci 163(1):170\u2013181. https:\/\/doi.org\/10.1093\/toxsci\/kfy026","journal-title":"Toxicol Sci"},{"key":"4235_CR157","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s00204-019-02445-2","volume":"93","author":"C Knebel","year":"2019","unstructured":"Knebel C, Buhrke T, S\u00fcssmuth R et al (2019a) Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines. Arch Toxicol 93:1311\u20131322. https:\/\/doi.org\/10.1007\/s00204-019-02445-2","journal-title":"Arch Toxicol"},{"key":"4235_CR158","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.fct.2018.11.039","volume":"123","author":"C Knebel","year":"2019","unstructured":"Knebel C, Heise T, Zanger UM, Lampen A, Marx-Stoelting P, Braeuning A (2019b) The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food Chem Toxicol 123:481\u2013491. https:\/\/doi.org\/10.1016\/j.fct.2018.11.039","journal-title":"Food Chem Toxicol"},{"key":"4235_CR159","doi-asserted-by":"publisher","unstructured":"Kolaric TO, Nincevic V, Kuna L et al (2021) Drug-induced fatty liver disease: pathogenesis and treatment. J Clin Transl Hepatol 9:731\u2013737. https:\/\/doi.org\/10.14218\/JCTH.2020.00091","DOI":"10.14218\/JCTH.2020.00091"},{"key":"4235_CR160","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s004180100297","volume":"116","author":"R Koopman","year":"2001","unstructured":"Koopman R, Schaart G, Hesselink MK (2001) Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids. Histochem Cell Biol 116:63\u201368. https:\/\/doi.org\/10.1007\/s004180100297","journal-title":"Histochem Cell Biol"},{"issue":"4","key":"4235_CR161","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.cmet.2011.07.013","volume":"14","author":"N Krahmer","year":"2011","unstructured":"Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman H, Schmidt-Supprian M, Vance D, Mann M, Farese R Jr., Walther T (2011) Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab 14(4):504\u2013515. https:\/\/doi.org\/10.1016\/j.cmet.2011.07.013","journal-title":"Cell Metab"},{"key":"4235_CR162","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/toxsci\/kfab069","volume":"183","author":"T Kralj","year":"2021","unstructured":"Kralj T, Brouwer KLR, Creek DJ (2021) Analytical and omics-based advances in the study of drug-induced liver injury. Toxicol Sci 183:1\u201313. https:\/\/doi.org\/10.1093\/toxsci\/kfab069","journal-title":"Toxicol Sci"},{"key":"4235_CR163","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1007\/s00204-019-02501-x","volume":"93","author":"NI Kramer","year":"2019","unstructured":"Kramer NI, Hoffmans Y, Wu S et al (2019) Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs. Arch Toxicol 93:2115\u20132125. https:\/\/doi.org\/10.1007\/s00204-019-02501-x","journal-title":"Arch Toxicol"},{"key":"4235_CR164","doi-asserted-by":"publisher","unstructured":"Krebs A, Waldmann T, Wilks MF et al (2019) Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data. ALTEX 36:682\u2013699. https:\/\/doi.org\/10.14573\/altex.1909271","DOI":"10.14573\/altex.1909271"},{"key":"4235_CR165","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/10937404.2010.483176","volume":"13","author":"D Krewski","year":"2010","unstructured":"Krewski D, Acosta D, Andersen M et al (2010) Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Crit Rev 13:51\u2013138. https:\/\/doi.org\/10.1080\/10937404.2010.483176","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"4235_CR166","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00204-019-02613-4","volume":"94","author":"D Krewski","year":"2020","unstructured":"Krewski D, Andersen ME, Tyshenko MG et al (2020) Toxicity testing in the 21st century: progress in the past decade and future perspectives. Arch Toxicol 94:1\u201358. https:\/\/doi.org\/10.1007\/s00204-019-02613-4","journal-title":"Arch Toxicol"},{"key":"4235_CR167","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.tem.2010.01.001","volume":"21","author":"JR Krycer","year":"2010","unstructured":"Krycer JR, Sharpe LJ, Luu W, Brown AJ (2010) The Akt\u2013SREBP nexus: cell signaling meets lipid metabolism. Trends Endocrinol Metab 21:268\u2013276. https:\/\/doi.org\/10.1016\/j.tem.2010.01.001","journal-title":"Trends Endocrinol Metab"},{"key":"4235_CR168","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112309","volume":"220","author":"T Ku","year":"2021","unstructured":"Ku T, Zhou M, Hou Y et al (2021) Tebuconazole induces liver injury coupled with ROS-mediated hepatic metabolism disorder. Ecotoxicol Environ Saf 220:112309. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112309","journal-title":"Ecotoxicol Environ Saf"},{"key":"4235_CR169","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1126880","volume":"14","author":"B Kubickova","year":"2023","unstructured":"Kubickova B, Jacobs MN (2023) Development of a reference and proficiency chemical list for human steatosis endpoints in vitro. Front Endocrinol 14:1126880. https:\/\/doi.org\/10.3389\/fendo.2023.1126880","journal-title":"Front Endocrinol"},{"key":"4235_CR170","doi-asserted-by":"publisher","first-page":"15547","DOI":"10.1074\/jbc.M113.473298","volume":"288","author":"O Kuda","year":"2013","unstructured":"Kuda O, Pietka TA, Demianova Z et al (2013) Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages. J Biol Chem 288:15547\u201315555. https:\/\/doi.org\/10.1074\/jbc.M113.473298","journal-title":"J Biol Chem"},{"issue":"10","key":"4235_CR171","doi-asserted-by":"publisher","DOI":"10.3390\/foods10102242","volume":"10","author":"H-C Kwon","year":"2021","unstructured":"Kwon H-C, Kim D-H, Jeong C-H, Kim Y-J, Han J-H, Lim S-J, Shin D-M, Kim D-W, Han S-G (2021) Tebuconazole fungicide induces lipid accumulation and oxidative stress in HepG2 cells. Foods 10(10):2242. https:\/\/doi.org\/10.3390\/foods10102242","journal-title":"Foods"},{"key":"4235_CR172","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.tiv.2018.01.023","volume":"48","author":"JA Kyffin","year":"2018","unstructured":"Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Mistry P, Webb SD (2018) Impact of cell types and culture methods on the functionality of in vitro liver systems \u2013 a review of cell systems for hepatotoxicity assessment. Toxicol in Vitro 48:262\u2013275. https:\/\/doi.org\/10.1016\/j.tiv.2018.01.023","journal-title":"Toxicol in Vitro"},{"key":"4235_CR173","unstructured":"Policy Labs (2025) Roadmap to Reduce Animal Testing \u2013 The EU Talks, the US Acts!"},{"key":"4235_CR174","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00204-020-02685-7","volume":"94","author":"A Lasch","year":"2020","unstructured":"Lasch A, Alarcan J, Lampen A et al (2020) Combinations of LXR and RXR agonists induce triglyceride accumulation in human HepaRG cells in a synergistic manner. Arch Toxicol 94:1303\u20131320. https:\/\/doi.org\/10.1007\/s00204-020-02685-7","journal-title":"Arch Toxicol"},{"key":"4235_CR175","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1007\/s00204-021-02997-2","volume":"95","author":"A Lasch","year":"2021","unstructured":"Lasch A, Marx-Stoelting P, Braeuning A, Lichtenstein D (2021) More than additive effects on liver triglyceride accumulation by combinations of steatotic and non-steatotic pesticides in HepaRG cells. Arch Toxicol 95:1397\u20131411. https:\/\/doi.org\/10.1007\/s00204-021-02997-2","journal-title":"Arch Toxicol"},{"key":"4235_CR176","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1021\/mp700121u","volume":"5","author":"JH Lee","year":"2008","unstructured":"Lee JH, Zhou J, Xie W (2008) PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks. Mol Pharm 5:60\u201366. https:\/\/doi.org\/10.1021\/mp700121u","journal-title":"Mol Pharm"},{"key":"4235_CR177","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1053\/j.gastro.2010.03.033","volume":"139","author":"JH Lee","year":"2010","unstructured":"Lee JH, Wada T, Febbraio M et al (2010) A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 139:653\u2013663. https:\/\/doi.org\/10.1053\/j.gastro.2010.03.033","journal-title":"Gastroenterology"},{"key":"4235_CR178","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.3390\/antiox10081314","volume":"10","author":"S-C Lee","year":"2021","unstructured":"Lee S-C, Jee S-C, Kim M et al (2021) Curcumin suppresses the lipid accumulation and oxidative stress induced by benzo[a]pyrene toxicity in HepG2 cells. Antioxidants 10:1314. https:\/\/doi.org\/10.3390\/antiox10081314","journal-title":"Antioxidants"},{"issue":"22","key":"4235_CR179","doi-asserted-by":"publisher","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","volume":"270","author":"JM Lehmann","year":"1995","unstructured":"Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3). J Biol Chem 270(22):12953\u201312956. https:\/\/doi.org\/10.1074\/jbc.270.22.12953","journal-title":"J Biol Chem"},{"key":"4235_CR180","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1007\/s00204-017-2045-3","volume":"91","author":"M Leist","year":"2017","unstructured":"Leist M, Ghallab A, Graepel R et al (2017) Adverse outcome pathways: opportunities, limitations and open questions. Arch Toxicol 91:3477\u20133505. https:\/\/doi.org\/10.1007\/s00204-017-2045-3","journal-title":"Arch Toxicol"},{"key":"4235_CR181","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1053\/jhep.2003.50309","volume":"38","author":"P Lett\u00e9ron","year":"2003","unstructured":"Lett\u00e9ron P, Sutton A, Mansouri A et al (2003) Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology 38:133\u2013140. https:\/\/doi.org\/10.1053\/jhep.2003.50309","journal-title":"Hepatology"},{"issue":"1","key":"4235_CR182","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00507-y","volume":"10","author":"X Li","year":"2020","unstructured":"Li X, Wang H (2020) Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease. Cell Biosci 10(1):140. https:\/\/doi.org\/10.1186\/s13578-020-00507-y","journal-title":"Cell Biosci"},{"issue":"6","key":"4235_CR183","doi-asserted-by":"publisher","first-page":"10492","DOI":"10.3390\/ijms150610492","volume":"15","author":"L Li","year":"2014","unstructured":"Li L, Han J, Wang Z, Liu J, Wei J, Xiong S, Zhao Z (2014) Mass spectrometry methodology in lipid analysis. Int J Mol Sci 15(6):10492\u201310507. https:\/\/doi.org\/10.3390\/ijms150610492","journal-title":"Int J Mol Sci"},{"key":"4235_CR184","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113986","volume":"179","author":"Y Li","year":"2023","unstructured":"Li Y, Liang N, Tang T et al (2023) Low-dose benzo[a]pyrene exposure induces hepatic lipid deposition through LCMT1\/PP2Ac-mediated autophagy inhibition. Food Chem Toxicol 179:113986. https:\/\/doi.org\/10.1016\/j.fct.2023.113986","journal-title":"Food Chem Toxicol"},{"key":"4235_CR185","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116390","volume":"278","author":"S Li","year":"2024","unstructured":"Li S, Qiao Z, Huang M, Lao Q, Zhang Q, Xing Yu, Pan S, Martin FL, Liu H, Pang W (2024) Combined exposure of polystyrene microplastics and benzo[a]pyrene in rat: study of the oxidative stress effects in the liver. Ecotoxicol Environ Saf 278:116390. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116390","journal-title":"Ecotoxicol Environ Saf"},{"key":"4235_CR186","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1194\/jlr.D400023-JLR200","volume":"46","author":"J Liao","year":"2005","unstructured":"Liao J, Sportsman R, Harris J, Stahl A (2005) Real-time quantification of fatty acid uptake using a novel fluorescence assay. J Lipid Res 46:597\u2013602. https:\/\/doi.org\/10.1194\/jlr.D400023-JLR200","journal-title":"J Lipid Res"},{"key":"4235_CR187","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111283","volume":"139","author":"D Lichtenstein","year":"2020","unstructured":"Lichtenstein D, Luckert C, Alarcan J et al (2020) An adverse outcome pathway-based approach to assess steatotic mixture effects of hepatotoxic pesticides in vitro. Food Chem Toxicol 139:111283. https:\/\/doi.org\/10.1016\/j.fct.2020.111283","journal-title":"Food Chem Toxicol"},{"key":"4235_CR188","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152857","volume":"459","author":"D Lichtenstein","year":"2021","unstructured":"Lichtenstein D, Lasch A, Alarcan J et al (2021) An eight-compound mixture but not corresponding concentrations of individual chemicals induces triglyceride accumulation in human liver cells. Toxicology 459:152857. https:\/\/doi.org\/10.1016\/j.tox.2021.152857","journal-title":"Toxicology"},{"key":"4235_CR189","doi-asserted-by":"publisher","first-page":"962","DOI":"10.17179\/EXCLI2020-2214","volume":"19","author":"KG Lima","year":"2020","unstructured":"Lima KG, Schneider Levorse VG, Rosa Garcia MC et al (2020) <article-title update=\u201cadded\u201d>Octyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-gamma gene expression. EXCLI J 19:962\u2013971. https:\/\/doi.org\/10.17179\/EXCLI2020-2214","journal-title":"EXCLI J"},{"key":"4235_CR190","first-page":"1","volume":"30","author":"KG Lima","year":"2021","unstructured":"Lima KG, Xavier LL, Cappellari AR et al (2021) A simple method of analyzing lipid droplets combining Oil Red O staining and confocal microscopy. Acta Microsc 30:1\u20139","journal-title":"Acta Microsc"},{"issue":"9","key":"4235_CR191","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.bbalip.2017.05.001","volume":"1862","author":"Y Lin","year":"2017","unstructured":"Lin Y, Ding D, Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J, Dong S (2017) Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. Biochimica Et Biophysica Acta (BBA) - Mol Cell Biol Lipids 1862(9):869\u2013882. https:\/\/doi.org\/10.1016\/j.bbalip.2017.05.001","journal-title":"Biochimica Et Biophysica Acta (BBA) - Mol Cell Biol Lipids"},{"key":"4235_CR192","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1073\/pnas.0630588100","volume":"100","author":"LL Listenberger","year":"2003","unstructured":"Listenberger LL, Han X, Lewis SE et al (2003) Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci 100:3077\u20133082. https:\/\/doi.org\/10.1073\/pnas.0630588100","journal-title":"Proc Natl Acad Sci"},{"key":"4235_CR193","doi-asserted-by":"publisher","unstructured":"Listenberger LL, Studer AM, Brown DA, Wolins NE (2016) Fluorescent detection of lipid droplets and associated proteins. Curr Protoc Cell Biol 71 https:\/\/doi.org\/10.1002\/cpcb.7","DOI":"10.1002\/cpcb.7"},{"key":"4235_CR194","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.tips.2018.12.001","volume":"40","author":"Z Liu","year":"2019","unstructured":"Liu Z, Huang R, Roberts R, Tong W (2019) Toxicogenomics \u2013 a 2020 vision. Trends Pharmacol Sci 40:92\u2013103. https:\/\/doi.org\/10.1016\/j.tips.2018.12.001","journal-title":"Trends Pharmacol Sci"},{"key":"4235_CR195","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115250","volume":"205","author":"J Liu","year":"2022","unstructured":"Liu J, Yao B, Gao L, Zhang Y, Huang S, Wang X (2022) Emerging role of carboxylesterases in nonalcoholic fatty liver disease. Biochem Pharmacol 205:115250. https:\/\/doi.org\/10.1016\/j.bcp.2022.115250","journal-title":"Biochem Pharmacol"},{"key":"4235_CR196","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106305","volume":"119","author":"J Liu","year":"2024","unstructured":"Liu J, Dang L, Yang J, He B, Zhao F, Xin W (2024a) HPP-1S attenuates oleic acid-induced steatosis in HepG2 cells and nonalcoholic fatty liver disease in a rat model of high-fat diet-induced obesity. J Funct Foods 119:106305. https:\/\/doi.org\/10.1016\/j.jff.2024.106305","journal-title":"J Funct Foods"},{"issue":"11","key":"4235_CR197","doi-asserted-by":"publisher","DOI":"10.1289\/EHP14634","volume":"132","author":"Y Liu","year":"2024","unstructured":"Liu Y, Ma X, Le Y, Feng J, Xu M, Wang W, Wang C (2024b) Organophosphorus flame retardants and metabolic disruption: an in silico, in vitro, and in vivo study focusing on adiponectin receptors. Environ Health Perspect 132(11):117003. https:\/\/doi.org\/10.1289\/EHP14634","journal-title":"Environ Health Perspect"},{"key":"4235_CR198","unstructured":"LiverTox (2012) Clinical course and diagnosis of drug induced liver disease. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases"},{"key":"4235_CR199","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1016\/j.bbamcr.2016.01.023","volume":"1863","author":"N Longo","year":"2016","unstructured":"Longo N, Frigeni M, Pasquali M (2016) Carnitine transport and fatty acid oxidation. Biochim Biophys Acta 1863:2422\u20132435. https:\/\/doi.org\/10.1016\/j.bbamcr.2016.01.023","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"4235_CR200","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105203","volume":"25","author":"E L\u00f3pez-Pascual","year":"2024","unstructured":"L\u00f3pez-Pascual E, Rienda I, Perez-Rojas J, Rapisarda A, Garcia-Llorens G, Jover R, Castell JV (2024) Drug-induced fatty liver disease (DIFLD): a comprehensive analysis of clinical, biochemical, and histopathological data for mechanisms identification and consistency with current adverse outcome pathways. Int J Mol Sci 25(10):5203. https:\/\/doi.org\/10.3390\/ijms25105203","journal-title":"Int J Mol Sci"},{"key":"4235_CR201","doi-asserted-by":"publisher","first-page":"4891","DOI":"10.1021\/cr078381n","volume":"107","author":"A Loudet","year":"2007","unstructured":"Loudet A, Burgess K (2007) BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Chem Rev 107:4891\u20134932. https:\/\/doi.org\/10.1021\/cr078381n","journal-title":"Chem Rev"},{"issue":"2","key":"4235_CR202","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.toxlet.2013.06.243","volume":"222","author":"C Luckert","year":"2013","unstructured":"Luckert C, Ehlers A, Buhrke T, Seidel A, Lampen A, Hessel S (2013) Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR. Toxicol Lett 222(2):180\u2013188. https:\/\/doi.org\/10.1016\/j.toxlet.2013.06.243","journal-title":"Toxicol Lett"},{"key":"4235_CR203","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1021\/acs.chemrestox.8b00112","volume":"31","author":"C Luckert","year":"2018","unstructured":"Luckert C, Braeuning A, de Sousa G et al (2018) Adverse outcome pathway-driven analysis of liver steatosis in vitro\u202f: a case study with cyproconazole. Chem Res Toxicol 31:784\u2013798. https:\/\/doi.org\/10.1021\/acs.chemrestox.8b00112","journal-title":"Chem Res Toxicol"},{"key":"4235_CR204","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.818159","volume":"13","author":"T Luo","year":"2022","unstructured":"Luo T, Jiang S, Zhou B, Song Q, Du J, Liu P, Wang X, Song H, Shao C (2022) Protective effect of isoorientin on oleic acid-induced oxidative damage and steatosis in rat liver cells. Front Pharmacol 13:818159. https:\/\/doi.org\/10.3389\/fphar.2022.818159","journal-title":"Front Pharmacol"},{"key":"4235_CR205","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2024.111008","volume":"274","author":"SA Lyons","year":"2024","unstructured":"Lyons SA, McClelland GB (2024) Commentary: tracing the fate of metabolic substrates during changes in whole-body energy expenditure in mice. Comp Biochem Physiol B Biochem Mol Biol 274:111008. https:\/\/doi.org\/10.1016\/j.cbpb.2024.111008","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"4235_CR206","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152585","volume":"445","author":"L Ma","year":"2020","unstructured":"Ma L, Wang Y, Chen X et al (2020a) Involvement of CYP2E1-ROS-CD36\/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro. Toxicology 445:152585. https:\/\/doi.org\/10.1016\/j.tox.2020.152585","journal-title":"Toxicology"},{"key":"4235_CR207","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1038\/s41598-020-58334-7","volume":"10","author":"Y Ma","year":"2020","unstructured":"Ma Y, Wang W, Devarakonda T et al (2020b) Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. Sci Rep 10:1450. https:\/\/doi.org\/10.1038\/s41598-020-58334-7","journal-title":"Sci Rep"},{"key":"4235_CR208","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2025.154210","volume":"517","author":"A Maerten","year":"2025","unstructured":"Maerten A, Drees A, Jiang J, Sanz-Serrano J, Devisscher L, Vinken M (2025) In vitro test battery for testing molecular initiating events in chemical-induced cholestasis. Toxicology 517:154210. https:\/\/doi.org\/10.1016\/j.tox.2025.154210","journal-title":"Toxicology"},{"key":"4235_CR209","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2217\/clp.09.9","volume":"4","author":"F Magkos","year":"2009","unstructured":"Magkos F, Mittendorfer B (2009) Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo. Clin Lipidol 4:215\u2013230. https:\/\/doi.org\/10.2217\/clp.09.9","journal-title":"Clin Lipidol"},{"issue":"2","key":"4235_CR210","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/toxsci\/kfad012","volume":"192","author":"KA Magurany","year":"2023","unstructured":"Magurany KA, Chang X, Clewell R, Coecke S, Haugabrooks E, Marty S (2023) A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment. Toxicol Sci 192(2):155\u2013177. https:\/\/doi.org\/10.1093\/toxsci\/kfad012","journal-title":"Toxicol Sci"},{"key":"4235_CR211","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118639","volume":"294","author":"ML Maia","year":"2022","unstructured":"Maia ML, Sousa S, Pestana D, Faria A, Teixeira D, Delerue-Matos C, Domingues VF, Calhau C (2022) Impact of brominated flame retardants on lipid metabolism: an in vitro approach. Environ Pollut 294:118639. https:\/\/doi.org\/10.1016\/j.envpol.2021.118639","journal-title":"Environ Pollut"},{"key":"4235_CR212","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s00204-022-03439-3","volume":"97","author":"JM Malinowska","year":"2023","unstructured":"Malinowska JM, Palosaari T, Sund J et al (2023) Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line. Arch Toxicol 97:721\u2013735. https:\/\/doi.org\/10.1007\/s00204-022-03439-3","journal-title":"Arch Toxicol"},{"key":"4235_CR213","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3390\/cells9051192","volume":"9","author":"P Marx-Stoelting","year":"2020","unstructured":"Marx-Stoelting P, Knebel C, Braeuning A (2020) The connection of azole fungicides with xeno-sensing nuclear receptors, drug metabolism and hepatotoxicity. Cells 9:1192. https:\/\/doi.org\/10.3390\/cells9051192","journal-title":"Cells"},{"key":"4235_CR214","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3945\/an.113.004648","volume":"4","author":"DG Mashek","year":"2013","unstructured":"Mashek DG (2013) Hepatic fatty acid trafficking: multiple forks in the road123. Adv Nutr 4:697\u2013710. https:\/\/doi.org\/10.3945\/an.113.004648","journal-title":"Adv Nutr"},{"key":"4235_CR215","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101115","volume":"50","author":"DG Mashek","year":"2021","unstructured":"Mashek DG (2021) Hepatic lipid droplets: a balancing act between energy storage and metabolic dysfunction in NAFLD. Mol Metab 50:101115. https:\/\/doi.org\/10.1016\/j.molmet.2020.101115","journal-title":"Mol Metab"},{"key":"4235_CR216","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/01.mol.0000226119.20307.2b","volume":"17","author":"DG Mashek","year":"2006","unstructured":"Mashek DG, Coleman RA (2006) Cellular fatty acid uptake: the contribution of metabolism. Curr Opin Lipidol 17:274\u2013278. https:\/\/doi.org\/10.1097\/01.mol.0000226119.20307.2b","journal-title":"Curr Opin Lipidol"},{"key":"4235_CR217","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s40139-013-0022-y","volume":"1","author":"J Massart","year":"2013","unstructured":"Massart J, Begriche K, Buron N et al (2013) Drug-induced inhibition of mitochondrial fatty acid oxidation and steatosis. Curr Pathobiol Rep 1:147\u2013157. https:\/\/doi.org\/10.1007\/s40139-013-0022-y","journal-title":"Curr Pathobiol Rep"},{"issue":"6","key":"4235_CR218","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165763","volume":"1866","author":"E Matuszyk","year":"2020","unstructured":"Matuszyk E, Sierka E, Rodewald M, Bae H, Meyer T, Kus E, Chlopicki S, Schmitt M, Popp J, Baranska M (2020) Differential response of liver sinusoidal endothelial cells and hepatocytes to oleic and palmitic acid revealed by Raman and CARS imaging. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Dis 1866(6):165763. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165763","journal-title":"Biochimica Et Biophysica Acta (BBA) - Molecular Basis Dis"},{"key":"4235_CR219","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1124\/jpet.104.072785","volume":"311","author":"TC McCarthy","year":"2004","unstructured":"McCarthy TC, Pollak PT, Hanniman EA, Sinal CJ (2004) Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation. J Pharmacol Exp Ther 311:864\u2013873. https:\/\/doi.org\/10.1124\/jpet.104.072785","journal-title":"J Pharmacol Exp Ther"},{"key":"4235_CR220","doi-asserted-by":"publisher","first-page":"188","DOI":"10.2174\/138620710790596736","volume":"13","author":"JM McKim","year":"2010","unstructured":"McKim JM (2010) Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance. Comb Chem High Throughput Screen 13:188\u2013206. https:\/\/doi.org\/10.2174\/138620710790596736","journal-title":"Comb Chem High Throughput Screen"},{"key":"4235_CR221","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1089\/109793301753407948","volume":"14","author":"MK McMillian","year":"2001","unstructured":"McMillian MK, Grant ER, Zhong Z et al (2001) Nile red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis. In Vitr Mol Toxicol 14:177\u2013190. https:\/\/doi.org\/10.1089\/109793301753407948","journal-title":"In Vitr Mol Toxicol"},{"key":"4235_CR222","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.diff.2011.05.011","volume":"82","author":"V Mehta","year":"2011","unstructured":"Mehta V, Vezina CM (2011) Potential protective mechanisms of aryl hydrocarbon receptor (AHR) signaling in benign prostatic hyperplasia. Differ Res Biol Divers 82:211\u2013219. https:\/\/doi.org\/10.1016\/j.diff.2011.05.011","journal-title":"Differ Res Biol Divers"},{"key":"4235_CR223","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3109\/10408444.2015.1089471","volume":"46","author":"CL Mellor","year":"2016","unstructured":"Mellor CL, Steinmetz FP, Cronin MTD (2016) The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways. Crit Rev Toxicol 46:138\u2013152. https:\/\/doi.org\/10.3109\/10408444.2015.1089471","journal-title":"Crit Rev Toxicol"},{"key":"4235_CR224","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.2147\/DMSO.S437865","volume":"16","author":"D Meng","year":"2023","unstructured":"Meng D, Zhang F, Yu W, Zhang X, Yin G, Liang P, Feng Y, Chen S, Liu H (2023) Biological role and related natural products of SIRT1 in nonalcoholic fatty liver. Diabetes Metab Syndr Obes 16:4043\u20134064. https:\/\/doi.org\/10.2147\/DMSO.S437865","journal-title":"Diabetes Metab Syndr Obes"},{"key":"4235_CR225","first-page":"86","volume":"21","author":"L Miele","year":"2017","unstructured":"Miele L, Liguori A, Marrone G et al (2017) Fatty liver and drugs: the two sides of the same coin. Eur Rev Med Pharmacol Sci 21:86\u201394","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4235_CR226","doi-asserted-by":"publisher","first-page":"12848","DOI":"10.1038\/ncomms12848","volume":"7","author":"MB Mobin","year":"2016","unstructured":"Mobin MB, Gerstberger S, Teupser D et al (2016) The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation. Nat Commun 7:12848. https:\/\/doi.org\/10.1038\/ncomms12848","journal-title":"Nat Commun"},{"key":"4235_CR227","doi-asserted-by":"publisher","first-page":"S627","DOI":"10.33549\/physiolres.933224","volume":"64","author":"A Moravcov\u00e1","year":"2015","unstructured":"Moravcov\u00e1 A, \u010cervinkov\u00e1 Z, Ku\u010dera O et al (2015) The effect of oleic and palmitic acid on induction of steatosis and cytotoxicity on rat hepatocytes in primary culture. Physiol Res 64:S627\u2013S636. https:\/\/doi.org\/10.33549\/physiolres.933224","journal-title":"Physiol Res"},{"issue":"5","key":"4235_CR228","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1021\/cb500014r","volume":"9","author":"PJ Morris","year":"2014","unstructured":"Morris PJ, Medina-Cleghorn D, Heslin A, King SM, Orr J, Mulvihill MM, Krauss RM, Nomura DK (2014) Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia. ACS Chem Biol 9(5):1097\u20131103. https:\/\/doi.org\/10.1021\/cb500014r","journal-title":"ACS Chem Biol"},{"key":"4235_CR229","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.slasd.2022.06.003","volume":"27","author":"SM Moss","year":"2022","unstructured":"Moss SM, Schilp J, Yaakov M et al (2022) Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels. SLAS Discov 27:358\u2013368. https:\/\/doi.org\/10.1016\/j.slasd.2022.06.003","journal-title":"SLAS Discov"},{"issue":"1","key":"4235_CR230","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s11418-023-01756-0","volume":"78","author":"A Nagatomo","year":"2024","unstructured":"Nagatomo A, Kohno M, Kawakami H, Manse Y, Morikawa T (2024) Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver. J Nat Med 78(1):180\u2013190. https:\/\/doi.org\/10.1007\/s11418-023-01756-0","journal-title":"J Nat Med"},{"key":"4235_CR231","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106616","volume":"156","author":"R Naidu","year":"2021","unstructured":"Naidu R, Biswas B, Willett IR et al (2021) Chemical pollution: a growing peril and potential catastrophic risk to humanity. Environ Int 156:106616. https:\/\/doi.org\/10.1016\/j.envint.2021.106616","journal-title":"Environ Int"},{"issue":"7","key":"4235_CR232","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s00204-019-02465-y","volume":"93","author":"A Natale","year":"2019","unstructured":"Natale A, Vanmol K, Arslan A, Van Vlierberghe S, Dubruel P, Van Erps J, Thienpont H, Buzgo M, Boeckmans J, De Kock J, Vanhaecke T, Rogiers V, Rodrigues RM (2019) Technological advancements for the development of stem cell-based models for hepatotoxicity testing. Arch Toxicol 93(7):1789\u20131805. https:\/\/doi.org\/10.1007\/s00204-019-02465-y","journal-title":"Arch Toxicol"},{"key":"4235_CR233","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117855","volume":"289","author":"CK Negi","year":"2021","unstructured":"Negi CK, Bajard L, Kohoutek J, Blaha L (2021) An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis. Environ Pollut 289:117855. https:\/\/doi.org\/10.1016\/j.envpol.2021.117855","journal-title":"Environ Pollut"},{"key":"4235_CR234","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tox.2015.08.007","volume":"337","author":"F Neusch\u00e4fer-Rube","year":"2015","unstructured":"Neusch\u00e4fer-Rube F, Schraplau A, Schewe B et al (2015) Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes. Toxicology 337:1\u20139. https:\/\/doi.org\/10.1016\/j.tox.2015.08.007","journal-title":"Toxicology"},{"key":"4235_CR235","doi-asserted-by":"publisher","first-page":"10133","DOI":"10.1021\/es2029334","volume":"45","author":"A Novotna","year":"2011","unstructured":"Novotna A, Pavek P, Dvorak Z (2011) Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization. Environ Sci Technol 45:10133\u201310139. https:\/\/doi.org\/10.1021\/es2029334","journal-title":"Environ Sci Technol"},{"key":"4235_CR236","doi-asserted-by":"publisher","DOI":"10.1787\/44bb06c1-en","volume-title":"Guidance document for the Use of adverse outcome pathways in developing integrated approaches to testing and assessment (IATA)","author":"OECD","year":"2017","unstructured":"OECD (2017) Guidance document for the Use of adverse outcome pathways in developing integrated approaches to testing and assessment (IATA). OECD Publishing, Paris"},{"key":"4235_CR237","unstructured":"OECD (2018a) Guidance document on good in vitro method practices (GIVIMP). OECD Publishing, paris"},{"key":"4235_CR238","unstructured":"OECD (2018b) Users\u2019 handbook supplement to the guidance document for developing and assessing adverse outcome pathways: Series on Testing and Assessment No. 233 and Series on Adverse Outcome Pathways No. 1."},{"key":"4235_CR239","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","volume":"20","author":"JA Olzmann","year":"2019","unstructured":"Olzmann JA, Carvalho P (2019) Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol 20:137\u2013155. https:\/\/doi.org\/10.1038\/s41580-018-0085-z","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4235_CR240","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.tox.2015.07.005","volume":"336","author":"K Oshida","year":"2015","unstructured":"Oshida K, Vasani N, Thomas RS, Applegate D, Gonzalez FJ, Aleksunes LM, Klaassen CD, Corton JC (2015) Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). Toxicology 336:99\u2013112. https:\/\/doi.org\/10.1016\/j.tox.2015.07.005","journal-title":"Toxicology"},{"key":"4235_CR241","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1172\/JCI32752","volume":"118","author":"T Ota","year":"2008","unstructured":"Ota T, Gayet C, Ginsberg HN (2008) Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest 118:316\u2013332. https:\/\/doi.org\/10.1172\/JCI32752","journal-title":"J Clin Invest"},{"issue":"4","key":"4235_CR242","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.ymgme.2012.10.007","volume":"107","author":"AA Palladino","year":"2012","unstructured":"Palladino AA, Chen J, Kallish S, Stanley CA, Bennett MJ (2012) Measurement of tissue acyl-CoAs using flow-injection tandem mass spectrometry: acyl-CoA profiles in short-chain fatty acid oxidation defects. Mol Genet Metab 107(4):679\u2013683. https:\/\/doi.org\/10.1016\/j.ymgme.2012.10.007","journal-title":"Mol Genet Metab"},{"key":"4235_CR243","doi-asserted-by":"publisher","first-page":"4413","DOI":"10.1074\/jbc.M107460200","volume":"277","author":"M Pan","year":"2002","unstructured":"Pan M, Liang J, Fisher EA, Ginsberg HN (2002) The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis. J Biol Chem 277:4413\u20134421. https:\/\/doi.org\/10.1074\/jbc.M107460200","journal-title":"J Biol Chem"},{"key":"4235_CR244","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2022.111678","volume":"552","author":"K Panzitt","year":"2022","unstructured":"Panzitt K, Zollner G, Marschall H-U, Wagner M (2022) Recent advances on FXR-targeting therapeutics. Mol Cell Endocrinol 552:111678. https:\/\/doi.org\/10.1016\/j.mce.2022.111678","journal-title":"Mol Cell Endocrinol"},{"key":"4235_CR245","doi-asserted-by":"publisher","first-page":"E28","DOI":"10.1152\/ajpendo.90897.2008","volume":"297","author":"CM Paton","year":"2009","unstructured":"Paton CM, Ntambi JM (2009) Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab 297:E28\u2013E37. https:\/\/doi.org\/10.1152\/ajpendo.90897.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"4235_CR246","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.122714","volume":"340","author":"C Perez-Diaz","year":"2024","unstructured":"Perez-Diaz C, Uriz-Mart\u00ednez M, Ortega-Rico C, Leno-Duran E, Barrios-Rodr\u00edguez R, Salcedo-Bellido I, Arrebola JP, Requena P (2024) Phthalate exposure and risk of metabolic syndrome components: a systematic review. Environ Pollut 340:122714. https:\/\/doi.org\/10.1016\/j.envpol.2023.122714","journal-title":"Environ Pollut"},{"issue":"9","key":"4235_CR247","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1002\/etc.4505","volume":"38","author":"EJ Perkins","year":"2019","unstructured":"Perkins EJ, Ashauer R, Burgoon L, Conolly R, Landesmann B, Mackay C, Murphy CA, Pollesch N, Wheeler JR, Zupanic A, Scholz S (2019) Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment. Environ Toxicol Chem 38(9):1850\u20131865. https:\/\/doi.org\/10.1002\/etc.4505","journal-title":"Environ Toxicol Chem"},{"key":"4235_CR248","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1080\/01926230590522121","volume":"33","author":"TS Peters","year":"2005","unstructured":"Peters TS (2005) Do preclinical testing strategies help predict human hepatotoxic potentials? Toxicol Pathol 33:146\u2013154. https:\/\/doi.org\/10.1080\/01926230590522121","journal-title":"Toxicol Pathol"},{"key":"4235_CR249","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.tiv.2018.02.018","volume":"50","author":"AH Piersma","year":"2018","unstructured":"Piersma AH, Burgdorf T, Louekari K, Desprez B, Taalman R, Landsiedel R, Barroso J, Rogiers V, Eskes C, Oelgeschl\u00e4ger M, Whelan M, Braeuning A, Vinggaard AM, Kienhuis A, van Benthem J, Ezendam J (2018) Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies. Toxicol in Vitro 50:62\u201374. https:\/\/doi.org\/10.1016\/j.tiv.2018.02.018","journal-title":"Toxicol in Vitro"},{"issue":"4","key":"4235_CR250","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.bbalip.2013.12.006","volume":"1841","author":"P Pingitore","year":"2014","unstructured":"Pingitore P, Pirazzi C, Mancina RM, Motta BM, Indiveri C, Pujia A, Montalcini T, Hedfalk K, Romeo S (2014) Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function. Biochim Biophys Acta 1841(4):574\u2013580. https:\/\/doi.org\/10.1016\/j.bbalip.2013.12.006","journal-title":"Biochim Biophys Acta"},{"key":"4235_CR251","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbalip.2004.06.004","volume":"1686","author":"J Pohl","year":"2004","unstructured":"Pohl J, Ring A, Hermann T, Stremmel W (2004a) Role of FATP in parenchymal cell fatty acid uptake. Biochim Biophys Acta 1686:1\u20136. https:\/\/doi.org\/10.1016\/j.bbalip.2004.06.004","journal-title":"Biochim Biophys Acta"},{"key":"4235_CR252","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1079\/PNS2004341","volume":"63","author":"J Pohl","year":"2004","unstructured":"Pohl J, Ring A, Herrmann T, Stremmel W (2004b) New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae. Proc Nutr Soc 63:259\u2013262. https:\/\/doi.org\/10.1079\/PNS2004341","journal-title":"Proc Nutr Soc"},{"issue":"1","key":"4235_CR253","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0168-8278(00)00085-4","volume":"34","author":"X Ponsoda","year":"2001","unstructured":"Ponsoda X, Pareja E, G\u00f3mez-Lech\u00f3n M-J, Fabra R, Carrasco E, Trullenque R, Castell JV (2001) Drug biotransformation by human hepatocytes. In vitro\/in vivo metabolism by cells from the same donor. J Hepatol 34(1):19\u201325. https:\/\/doi.org\/10.1016\/S0168-8278(00)00085-4","journal-title":"J Hepatol"},{"key":"4235_CR254","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2021.105133","volume":"73","author":"S Proen\u00e7a","year":"2021","unstructured":"Proen\u00e7a S, Escher BI, Fischer FC, Fisher C, Gr\u00e9goire S, Hewitt NJ, Nicol B, Paini A, Kramer NI (2021) Effective exposure of chemicals in in vitro cell systems: a review of chemical distribution models. Toxicol in Vitro 73:105133. https:\/\/doi.org\/10.1016\/j.tiv.2021.105133","journal-title":"Toxicol in Vitro"},{"key":"4235_CR255","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1194\/jlr.M020156","volume":"53","author":"J Qi","year":"2012","unstructured":"Qi J, Lang W, Geisler JG et al (2012) The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res 53:1106\u20131116. https:\/\/doi.org\/10.1194\/jlr.M020156","journal-title":"J Lipid Res"},{"key":"4235_CR256","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.1912","volume":"6","author":"B Qiu","year":"2016","unstructured":"Qiu B, Simon MC (2016) BODIPY 493\/503 staining of neutral lipid droplets for microscopy and quantification by flow cytometry. Bio-Protoc 6:e1912. https:\/\/doi.org\/10.21769\/BioProtoc.1912","journal-title":"Bio-Protoc"},{"key":"4235_CR257","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1155271","volume":"14","author":"G Quint\u00e1s","year":"2023","unstructured":"Quint\u00e1s G, Castell JV, Moreno-Torres M (2023) The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics. Front Pharmacol 14:1155271. https:\/\/doi.org\/10.3389\/fphar.2023.1155271","journal-title":"Front Pharmacol"},{"key":"4235_CR258","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bcp.2018.07.005","volume":"155","author":"AD Quiroga","year":"2018","unstructured":"Quiroga AD, Lehner R (2018) Pharmacological intervention of liver triacylglycerol lipolysis: the good, the bad and the ugly. Biochem Pharmacol 155:233\u2013241. https:\/\/doi.org\/10.1016\/j.bcp.2018.07.005","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"4235_CR259","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03003-w","volume":"11","author":"P Rada","year":"2020","unstructured":"Rada P, Gonz\u00e1lez-Rodr\u00edguez \u00c1, Garc\u00eda-Monz\u00f3n C, Valverde \u00c1M (2020) Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? Cell Death Dis 11(9):802. https:\/\/doi.org\/10.1038\/s41419-020-03003-w","journal-title":"Cell Death Dis"},{"key":"4235_CR260","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1055\/s-0029-1240011","volume":"29","author":"K Raja","year":"2009","unstructured":"Raja K, Thung S, Fiel MI, Chang C (2009) Drug-induced steatohepatitis leading to cirrhosis: long-term toxicity of amiodarone use. Semin Liver Dis 29:423\u2013428. https:\/\/doi.org\/10.1055\/s-0029-1240011","journal-title":"Semin Liver Dis"},{"issue":"11","key":"4235_CR261","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1007\/s00204-023-03572-7","volume":"97","author":"S Ramirez-Hincapie","year":"2023","unstructured":"Ramirez-Hincapie S, Birk B, Ternes P, Giri V, Zickgraf FM, Haake V, Herold M, Kamp H, Driemert P, Landsiedel R, Richling E, Funk-Weyer D, van Ravenzwaay B (2023) Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin. Arch Toxicol 97(11):2903\u20132917. https:\/\/doi.org\/10.1007\/s00204-023-03572-7","journal-title":"Arch Toxicol"},{"key":"4235_CR262","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1055\/s-2001-12928","volume":"21","author":"MS Rao","year":"2001","unstructured":"Rao MS, Reddy JK (2001) Peroxisomal beta-oxidation and steatohepatitis. Semin Liver Dis 21:43\u201355. https:\/\/doi.org\/10.1055\/s-2001-12928","journal-title":"Semin Liver Dis"},{"issue":"5","key":"4235_CR263","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1111\/j.1440-1746.2008.05733.x","volume":"24","author":"M Ricchi","year":"2009","unstructured":"Ricchi M, Odoardi MR, Carulli L, Anzivino C, Ballestri S, Pinetti A, Fantoni LI, Marra F, Bertolotti M, Banni S, Lonardo A, Carulli N, Loria P (2009) Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 24(5):830\u2013840. https:\/\/doi.org\/10.1111\/j.1440-1746.2008.05733.x","journal-title":"J Gastroenterol Hepatol"},{"key":"4235_CR264","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1021\/jm000494a","volume":"44","author":"JA Robl","year":"2001","unstructured":"Robl JA, Sulsky R, Sun C-Q et al (2001) A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. J Med Chem 44:851\u2013856. https:\/\/doi.org\/10.1021\/jm000494a","journal-title":"J Med Chem"},{"issue":"3","key":"4235_CR265","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00204-015-1483-z","volume":"90","author":"RM Rodrigues","year":"2016","unstructured":"Rodrigues RM, Branson S, De Boe V, Sachinidis A, Rogiers V, De Kock J, Vanhaecke T (2016) In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol 90(3):677\u2013689. https:\/\/doi.org\/10.1007\/s00204-015-1483-z","journal-title":"Arch Toxicol"},{"key":"4235_CR266","doi-asserted-by":"publisher","unstructured":"Rogers GW, Nadanaciva S, Swiss R et al (2014) Assessment of fatty acid beta oxidation in cells and isolated mitochondria. Curr Protoc Toxicol 60 https:\/\/doi.org\/10.1002\/0471140856.tx2503s60","DOI":"10.1002\/0471140856.tx2503s60"},{"key":"4235_CR267","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ab.2012.06.013","volume":"428","author":"MC Rudolph","year":"2012","unstructured":"Rudolph MC, Karl Maluf N, Wellberg EA et al (2012) Mammalian fatty acid synthase activity from crude tissue lysates tracing 13C-labeled substrates using gas chromatography\u2013mass spectrometry. Anal Biochem 428:158\u2013166. https:\/\/doi.org\/10.1016\/j.ab.2012.06.013","journal-title":"Anal Biochem"},{"issue":"2","key":"4235_CR268","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00204-023-03649-3","volume":"98","author":"F Sadrabadi","year":"2024","unstructured":"Sadrabadi F, Alarcan J, Sprenger H, Braeuning A, Buhrke T (2024) Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes. Arch Toxicol 98(2):507\u2013524. https:\/\/doi.org\/10.1007\/s00204-023-03649-3","journal-title":"Arch Toxicol"},{"key":"4235_CR269","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.bbrc.2015.08.055","volume":"465","author":"N Saini","year":"2015","unstructured":"Saini N, Black PN, Montefusco D, DiRusso CC (2015) Fatty acid transport protein-2 inhibitor Grassofermata\/CB5 protects cells against lipid accumulation and toxicity. Biochem Biophys Res Commun 465:534\u2013541. https:\/\/doi.org\/10.1016\/j.bbrc.2015.08.055","journal-title":"Biochem Biophys Res Commun"},{"key":"4235_CR270","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/brv.12178","volume":"91","author":"FWB Sanders","year":"2016","unstructured":"Sanders FWB, Griffin JL (2016) De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose. Biol Rev Camb Philos Soc 91:452\u2013468. https:\/\/doi.org\/10.1111\/brv.12178","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"7","key":"4235_CR271","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.11.008","volume":"79","author":"A Sandoval","year":"2010","unstructured":"Sandoval A, Chokshi A, Jesch ED, Black PN, DiRusso CC (2010) Identification and characterization of small compound inhibitors of human FATP2. Biochem Pharmacol 79(7):990. https:\/\/doi.org\/10.1016\/j.bcp.2009.11.008","journal-title":"Biochem Pharmacol"},{"key":"4235_CR272","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1017\/S2040174420000057","volume":"12","author":"KE Sant","year":"2021","unstructured":"Sant KE, Moreau HM, Williams LM et al (2021) Embryonic exposures to mono-2-ethylhexyl phthalate (MEHP) induce larval steatosis in zebrafish independent of Nrf2a signaling. J Dev Orig Health Dis 12:132\u2013140. https:\/\/doi.org\/10.1017\/S2040174420000057","journal-title":"J Dev Orig Health Dis"},{"key":"4235_CR273","doi-asserted-by":"publisher","first-page":"789","DOI":"10.5604\/16652681.1171749","volume":"14","author":"SK Satapathy","year":"2015","unstructured":"Satapathy SK, Kuwajima V, Nadelson J et al (2015) Drug-induced fatty liver disease: an overview of pathogenesis and management. Ann Hepatol 14:789\u2013806. https:\/\/doi.org\/10.5604\/16652681.1171749","journal-title":"Ann Hepatol"},{"key":"4235_CR274","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108082","volume":"178","author":"S Schmeisser","year":"2023","unstructured":"Schmeisser S, Miccoli A, Von Bergen M, Berggren E, Braeuning A, Busch W, Desaintes C, Gourmelon A, Grafstr\u00f6m R, Harrill J, Hartung T, Herzler M, Kass GEN, Kleinstreuer N, Leist M, Luijten M, Marx-Stoelting P, Poetz O, van Ravenzwaay B, Roggeband R, Rogiers V, Roth A, Sanders P, Thomas RS, Marie Vinggaard A, Vinken M, van de Water B, Luch A, Tralau T (2023) New approach methodologies in human regulatory toxicology \u2013 not if, but how and when! Environ Int 178:108082. https:\/\/doi.org\/10.1016\/j.envint.2023.108082","journal-title":"Environ Int"},{"issue":"1","key":"4235_CR275","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00204-016-1805-9","volume":"91","author":"BZ Schmidt","year":"2017","unstructured":"Schmidt BZ, Lehmann M, Gutbier S, Nembo E, Noel S, Smirnova L, Forsby A, Hescheler J, Avci HX, Hartung T, Leist M, Kobol\u00e1k J, Dinny\u00e9s A (2017) In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities. Arch Toxicol 91(1):1\u201333. https:\/\/doi.org\/10.1007\/s00204-016-1805-9","journal-title":"Arch Toxicol"},{"issue":"11","key":"4235_CR276","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1194\/jlr.D073197","volume":"58","author":"JG Schnitzler","year":"2017","unstructured":"Schnitzler JG, Bernelot Moens SJ, Tiessens F, Bakker GJ, Dallinga-Thie GM, Groen AK, Nieuwdorp M, Stroes ESG, Kroon J (2017) Nile red quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy. J Lipid Res 58(11):2210\u20132219. https:\/\/doi.org\/10.1194\/jlr.D073197","journal-title":"J Lipid Res"},{"issue":"10","key":"4235_CR277","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1083\/jcb.201803153","volume":"218","author":"MB Schott","year":"2019","unstructured":"Schott MB, Weller SG, Schulze RJ, Krueger EW, Drizyte-Miller K, Casey CA, McNiven MA (2019) Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. J Cell Biol 218(10):3320\u20133335. https:\/\/doi.org\/10.1083\/jcb.201803153","journal-title":"J Cell Biol"},{"issue":"22","key":"4235_CR278","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1101\/gad.850400","volume":"14","author":"JR Schultz","year":"2000","unstructured":"Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B (2000) Role of LXRs in control of lipogenesis. Genes Dev 14(22):2831\u20132838. https:\/\/doi.org\/10.1101\/gad.850400","journal-title":"Genes Dev"},{"key":"4235_CR279","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/hep4.1056","volume":"1","author":"RJ Schulze","year":"2017","unstructured":"Schulze RJ, Dri\u017eyt\u0117 K, Casey CA, McNiven MA (2017) Hepatic lipophagy: new insights into autophagic catabolism of lipid droplets in the liver. Hepatol Commun 1:359\u2013369. https:\/\/doi.org\/10.1002\/hep4.1056","journal-title":"Hepatol Commun"},{"issue":"1","key":"4235_CR280","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00204-024-03893-1","volume":"99","author":"L Sch\u00fcrmeyer","year":"2025","unstructured":"Sch\u00fcrmeyer L, Peng C, Albrecht W, Brecklinghaus T, Baur P, Hengstler JG, Schorning K (2025) Design of optimal concentrations for in vitro cytotoxicity experiments. Arch Toxicol 99(1):357\u2013376. https:\/\/doi.org\/10.1007\/s00204-024-03893-1","journal-title":"Arch Toxicol"},{"issue":"52","key":"4235_CR281","doi-asserted-by":"publisher","first-page":"40236","DOI":"10.1074\/jbc.M608048200","volume":"281","author":"M Schweiger","year":"2006","unstructured":"Schweiger M, Schreiber R, Haemmerle G, Lass A, Fledelius C, Jacobsen P, Tornqvist H, Zechner R, Zimmermann R (2006) Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem 281(52):40236\u201340241. https:\/\/doi.org\/10.1074\/jbc.M608048200","journal-title":"J Biol Chem"},{"key":"4235_CR282","doi-asserted-by":"crossref","unstructured":"Schweiger M, Eichmann TO, Taschler U et al (2014) Measurement of lipolysis. In: Methods in Enzymology. Elsevier, pp 171\u2013193","DOI":"10.1016\/B978-0-12-800280-3.00010-4"},{"key":"4235_CR283","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.jhep.2024.04.026","volume":"81","author":"A Segovia-Zafra","year":"2024","unstructured":"Segovia-Zafra A, Villanueva-Paz M, Serras AS et al (2024) Control compounds for preclinical drug-induced liver injury assessment: consensus-driven systematic review by the ProEuroDILI network. J Hepatol 81:630\u2013640. https:\/\/doi.org\/10.1016\/j.jhep.2024.04.026","journal-title":"J Hepatol"},{"issue":"7","key":"4235_CR284","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/s00217-025-04741-x","volume":"251","author":"T \u015eekerler","year":"2025","unstructured":"\u015eekerler T, G\u00fclmez G, Alg\u00fcl KF, G\u00f6ger F, \u015eenkarde\u015f \u0130, \u015een A, \u015eener A (2025) Anti-lipid accumulation and antioxidant effects of the root extract from Rubus discolor and its phytochemical analysis. Eur Food Res Technol 251(7):1817\u20131829. https:\/\/doi.org\/10.1007\/s00217-025-04741-x","journal-title":"Eur Food Res Technol"},{"issue":"4","key":"4235_CR285","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1021\/acsmedchemlett.8b00423","volume":"10","author":"V Sepe","year":"2018","unstructured":"Sepe V, Marchian\u00f2 S, Finamore C, Baronissi G, Di Leva FS, Carino A, Biagioli M, Fiorucci C, Cassiano C, Monti MC, del Gaudio F, Novellino E, Limongelli V, Fiorucci S, Zampella A (2018) Novel isoxazole derivatives with potent FXR agonistic activity prevent acetaminophen-induced liver injury. ACS Med Chem Lett 10(4):407\u2013412. https:\/\/doi.org\/10.1021\/acsmedchemlett.8b00423","journal-title":"ACS Med Chem Lett"},{"key":"4235_CR286","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1194\/jlr.M069583","volume":"57","author":"W Shao","year":"2016","unstructured":"Shao W, Machamer CE, Espenshade PJ (2016) Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res 57:1564\u20131573. https:\/\/doi.org\/10.1194\/jlr.M069583","journal-title":"J Lipid Res"},{"key":"4235_CR287","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1039\/C5AN01623A","volume":"141","author":"A Sharma","year":"2016","unstructured":"Sharma A, Umar S, Kar P et al (2016) A new type of biocompatible fluorescent probe AFN for fixed and live cell imaging of intracellular lipid droplets. Analyst 141:137\u2013143. https:\/\/doi.org\/10.1039\/C5AN01623A","journal-title":"Analyst"},{"key":"4235_CR288","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1194\/jlr.M400371-JLR200","volume":"46","author":"V Sheena","year":"2005","unstructured":"Sheena V, Hertz R, Nousbeck J et al (2005) Transcriptional regulation of human microsomal triglyceride transfer protein by hepatocyte nuclear factor-4\u03b1. J Lipid Res 46:328\u2013341. https:\/\/doi.org\/10.1194\/jlr.M400371-JLR200","journal-title":"J Lipid Res"},{"key":"4235_CR289","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nrendo.2017.91","volume":"13","author":"H Shimano","year":"2017","unstructured":"Shimano H, Sato R (2017) SREBP-regulated lipid metabolism: convergent physiology\u2014divergent pathophysiology. Nat Rev Endocrinol 13:710\u2013730. https:\/\/doi.org\/10.1038\/nrendo.2017.91","journal-title":"Nat Rev Endocrinol"},{"key":"4235_CR290","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00394-005-0576-5","volume":"45","author":"ES Shin","year":"2006","unstructured":"Shin ES, Cho SY, Lee EH et al (2006) Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L\u2013carnitine. Eur J Nutr 45:159\u2013164. https:\/\/doi.org\/10.1007\/s00394-005-0576-5","journal-title":"Eur J Nutr"},{"key":"4235_CR291","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.taap.2003.12.020","volume":"199","author":"J Shipley","year":"2004","unstructured":"Shipley J (2004) Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol 199:275\u2013284. https:\/\/doi.org\/10.1016\/j.taap.2003.12.020","journal-title":"Toxicol Appl Pharmacol"},{"key":"4235_CR292","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1124\/dmd.110.035105","volume":"39","author":"SJ Shukla","year":"2011","unstructured":"Shukla SJ, Sakamuru S, Huang R et al (2011) Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos 39:151\u2013159. https:\/\/doi.org\/10.1124\/dmd.110.035105","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"4235_CR293","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.advms.2016.05.001","volume":"61","author":"K Siemionow","year":"2016","unstructured":"Siemionow K, Teul J, Dr\u0105gowski P, Pa\u0142ka J, Miltyk W (2016) New potential biomarkers of acetaminophen-induced hepatotoxicity. Adv Med Sci 61(2):325\u2013330. https:\/\/doi.org\/10.1016\/j.advms.2016.05.001","journal-title":"Adv Med Sci"},{"key":"4235_CR294","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10545-008-0841-x","volume":"31","author":"MFB Silva","year":"2008","unstructured":"Silva MFB, Aires CCP, Luis PBM et al (2008) Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review. J Inherit Metab Dis 31:205\u2013216. https:\/\/doi.org\/10.1007\/s10545-008-0841-x","journal-title":"J Inherit Metab Dis"},{"key":"4235_CR295","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/nature07976","volume":"458","author":"R Singh","year":"2009","unstructured":"Singh R, Kaushik S, Wang Y et al (2009) Autophagy regulates lipid metabolism. Nature 458:1131\u20131135. https:\/\/doi.org\/10.1038\/nature07976","journal-title":"Nature"},{"key":"4235_CR296","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0163-7827(02)00067-X","volume":"42","author":"S Smith","year":"2003","unstructured":"Smith S, Witkowski A, Joshi AK (2003) Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res 42:289\u2013317. https:\/\/doi.org\/10.1016\/S0163-7827(02)00067-X","journal-title":"Prog Lipid Res"},{"key":"4235_CR297","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1113\/jphysiol.2004.081679","volume":"565","author":"AC Smith","year":"2005","unstructured":"Smith AC, Bruce CR, Dyck DJ (2005) AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle. J Physiol 565:537\u2013546. https:\/\/doi.org\/10.1113\/jphysiol.2004.081679","journal-title":"J Physiol"},{"key":"4235_CR298","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116500","volume":"229","author":"T Smutny","year":"2024","unstructured":"Smutny T, Smutna L, Lochman L et al (2024) Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes. Biochem Pharmacol 229:116500. https:\/\/doi.org\/10.1016\/j.bcp.2024.116500","journal-title":"Biochem Pharmacol"},{"key":"4235_CR299","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","volume":"61","author":"S Softic","year":"2016","unstructured":"Softic S, Cohen DE, Kahn CR (2016) Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Dig Dis Sci 61:1282\u20131293. https:\/\/doi.org\/10.1007\/s10620-016-4054-0","journal-title":"Dig Dis Sci"},{"key":"4235_CR300","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.aohep.2019.11.010","volume":"19","author":"A Solano-Urrusquieta","year":"2020","unstructured":"Solano-Urrusquieta A, Morales-Gonz\u00e1lez JA, Castro-Narro GE et al (2020) NRF-2 and nonalcoholic fatty liver disease. Ann Hepatol 19:458\u2013465. https:\/\/doi.org\/10.1016\/j.aohep.2019.11.010","journal-title":"Ann Hepatol"},{"key":"4235_CR301","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1039\/C2TX20051A","volume":"2","author":"VY Soldatow","year":"2013","unstructured":"Soldatow VY, LeCluyse EL, Griffith LG, Rusyn I (2013) In vitro models for liver toxicity testing. Toxicol Res 2:23\u201339. https:\/\/doi.org\/10.1039\/C2TX20051A","journal-title":"Toxicol Res"},{"key":"4235_CR302","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.102297","volume":"102","author":"H Song","year":"2023","unstructured":"Song H, Yang R, Zhang J et al (2023) Oleic acid-induced steatosis model establishment in LMH cells and its effect on lipid metabolism. Poult Sci 102:102297. https:\/\/doi.org\/10.1016\/j.psj.2022.102297","journal-title":"Poult Sci"},{"key":"4235_CR303","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1111\/j.1600-0854.2009.00980.x","volume":"10","author":"J Spandl","year":"2009","unstructured":"Spandl J, White DJ, Peychl J, Thiele C (2009) Live cell multicolor imaging of lipid droplets with a new dye, LD540. Traffic 10:1579\u20131584. https:\/\/doi.org\/10.1111\/j.1600-0854.2009.00980.x","journal-title":"Traffic"},{"key":"4235_CR304","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/598358","volume":"2011","author":"EE Spangenburg","year":"2011","unstructured":"Spangenburg EE, Pratt SJP, Wohlers LM, Lovering RM (2011) Use of BODIPY (493\/503) to visualize intramuscular lipid droplets in skeletal muscle. BioMed Res Int 2011:598358. https:\/\/doi.org\/10.1155\/2011\/598358","journal-title":"BioMed Res Int"},{"key":"4235_CR305","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/nbm.1419","volume":"23","author":"NK Srivastava","year":"2010","unstructured":"Srivastava NK, Pradhan S, Mittal B, Gowda GAN (2010) High resolution NMR based analysis of serum lipids in Duchenne muscular dystrophy patients and its possible diagnostic significance. NMR Biomed 23:13\u201322. https:\/\/doi.org\/10.1002\/nbm.1419","journal-title":"NMR Biomed"},{"key":"4235_CR306","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.tem.2008.11.001","volume":"20","author":"X Su","year":"2009","unstructured":"Su X, Abumrad NA (2009) Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab 20:72\u201377. https:\/\/doi.org\/10.1016\/j.tem.2008.11.001","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"4235_CR307","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086795","volume":"9","author":"E Szalowska","year":"2014","unstructured":"Szalowska E, Van Der Burg B, Man H-Y, Hendriksen PJM, Peijnenburg AACM (2014) Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices. PLoS ONE 9(1):e86795. https:\/\/doi.org\/10.1371\/journal.pone.0086795","journal-title":"PLoS ONE"},{"issue":"9","key":"4235_CR308","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22095038","volume":"22","author":"A Tabernilla","year":"2021","unstructured":"Tabernilla A, dos Santos Rodrigues B, Pieters A, Caufriez A, Leroy K, Van Campenhout R, Cooreman A, Gomes AR, Arnesdotter E, Gijbels E, Vinken M (2021) In vitro liver toxicity testing of chemicals: a pragmatic approach. Int J Mol Sci 22(9):5038. https:\/\/doi.org\/10.3390\/ijms22095038","journal-title":"Int J Mol Sci"},{"key":"4235_CR309","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116658","volume":"175","author":"Y Tang","year":"2024","unstructured":"Tang Y, Fan Y, Wang Y, Wang D, Huang Q, Chen T, Cao X, Wen C, Shen X, Li J, You Y (2024) A current understanding of FXR in NAFLD: the multifaceted regulatory role of FXR and novel lead discovery for drug development. Biomed Pharmacother 175:116658. https:\/\/doi.org\/10.1016\/j.biopha.2024.116658","journal-title":"Biomed Pharmacother"},{"key":"4235_CR310","doi-asserted-by":"publisher","DOI":"10.3389\/fddsv.2025.1536756","volume":"5","author":"K Taylor","year":"2025","unstructured":"Taylor K, Ram R, Ewart L, Goldring C, Russomanno G, Aithal GP, Kostrzewski T, Bauch C, Wilkinson JM, Modi S, Kenna JG, Bailey J (2025) Perspective: how complex in vitro models are addressing the challenges of predicting drug-induced liver injury. Front Drug Discov 5:1536756. https:\/\/doi.org\/10.3389\/fddsv.2025.1536756","journal-title":"Front Drug Discov"},{"issue":"8","key":"4235_CR311","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.2174\/138920012802850001","volume":"13","author":"M Teresa Donato","year":"2012","unstructured":"Teresa Donato M, Jose Gomez-Lechon M (2012) Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates. Curr Drug Metab 13(8):1160\u20131173. https:\/\/doi.org\/10.2174\/138920012802850001","journal-title":"Curr Drug Metab"},{"key":"4235_CR312","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.tcb.2020.11.006","volume":"31","author":"AR Thiam","year":"2021","unstructured":"Thiam AR, Ikonen E (2021) Lipid doplet nucleation. Trends Cell Biol 31:108\u2013118. https:\/\/doi.org\/10.1016\/j.tcb.2020.11.006","journal-title":"Trends Cell Biol"},{"key":"4235_CR313","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.yrtph.2014.09.009","volume":"70","author":"KE Tollefsen","year":"2014","unstructured":"Tollefsen KE, Scholz S, Cronin MT et al (2014) Applying adverse outcome pathways (AOPs) to support integrated approaches to testing and assessment (IATA). Regul Toxicol Pharmacol 70:629\u2013640. https:\/\/doi.org\/10.1016\/j.yrtph.2014.09.009","journal-title":"Regul Toxicol Pharmacol"},{"issue":"1","key":"4235_CR314","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/toxsci\/kfs083","volume":"127","author":"L Tolosa","year":"2012","unstructured":"Tolosa L, Pinto S, Donato MT, Lahoz A, Castell JV, O\u2019Connor JE, G\u00f3mez-Lech\u00f3n MJ (2012) Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs. Toxicol Sci 127(1):187\u2013198. https:\/\/doi.org\/10.1093\/toxsci\/kfs083","journal-title":"Toxicol Sci"},{"key":"4235_CR315","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3390\/biom10010118","volume":"10","author":"M Topolska","year":"2020","unstructured":"Topolska M, Mart\u00ednez-Monta\u00f1\u00e9s F, Ejsing CS (2020) A simple and direct assay for monitoring fatty acid synthase activity and product-specificity by high-resolution mass spectrometry. Biomolecules 10:118. https:\/\/doi.org\/10.3390\/biom10010118","journal-title":"Biomolecules"},{"key":"4235_CR316","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1080\/15548627.2017.1319544","volume":"13","author":"T-H Tsai","year":"2017","unstructured":"Tsai T-H, Chen E, Li L et al (2017) The constitutive lipid droplet protein PLIN2 regulates autophagy in liver. Autophagy 13:1130\u20131144. https:\/\/doi.org\/10.1080\/15548627.2017.1319544","journal-title":"Autophagy"},{"issue":"20","key":"4235_CR317","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1039\/C9CC09993J","volume":"56","author":"S Uchinomiya","year":"2020","unstructured":"Uchinomiya S, Matsunaga N, Kamoda K, Kawagoe R, Tsuruta A, Ohdo S, Ojida A (2020) Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells. Chem Commun 56(20):3023\u20133026. https:\/\/doi.org\/10.1039\/C9CC09993J","journal-title":"Chem Commun"},{"key":"4235_CR318","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.tox.2017.11.013","volume":"393","author":"SGJ van Breda","year":"2018","unstructured":"van Breda SGJ, Claessen SMH, van Herwijnen M, Theunissen DHJ, Jennen DGJ, de Kok TMCM, Kleinjans JCS (2018) Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology 393:160\u2013170. https:\/\/doi.org\/10.1016\/j.tox.2017.11.013","journal-title":"Toxicology"},{"key":"4235_CR81","doi-asserted-by":"crossref","unstructured":"Van Delft J, Mathijs K, Polman J et al (2014) Hepatotoxicity screening on in vitro models and the role of omics. In: Toxicogenomics-Based Cellular Models. Elsevier, pp 193\u2013212","DOI":"10.1016\/B978-0-12-397862-2.00010-3"},{"issue":"3","key":"4235_CR319","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1021\/tx4004165","volume":"27","author":"WF Van Den Hof","year":"2014","unstructured":"Van Den Hof WF, Coonen ML, Van Herwijnen M, den Van Hof WFPM, Coonen MLJ, Brauers K, Wodzig WKWH, van Delft JHM, Kleinjans JCS (2014) Classification of hepatotoxicants using HepG2 cells: a proof of principle study. Chem Res Toxicol 27(3):433\u2013442. https:\/\/doi.org\/10.1021\/tx4004165","journal-title":"Chem Res Toxicol"},{"key":"4235_CR320","unstructured":"Verheij ER, Stevens L, Morrison MC, et al 14C-Pathway probing as dynamic biomarker read-out: de novo lipogenesis using 14C-labeled acetate and accelerator mass spectrometry. https:\/\/www.tno-pharma.com\/LipoGenesis.pdf. Accessed 31 October 2024."},{"key":"4235_CR321","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2024.153814","volume":"505","author":"A Verhoeven","year":"2024","unstructured":"Verhoeven A, Van Ertvelde J, Boeckmans J, Gatzios A, Jover R, Lindeman B, Lopez-Soop G, Rodrigues RM, Rapisarda A, Sanz-Serrano J, Stinckens M, Sepehri S, Teunis M, Vinken M, Jiang J, Vanhaecke T (2024) A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis. Toxicology 505:153814. https:\/\/doi.org\/10.1016\/j.tox.2024.153814","journal-title":"Toxicology"},{"issue":"2","key":"4235_CR322","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1093\/toxsci\/kfu199","volume":"142","author":"DL Villeneuve","year":"2014","unstructured":"Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M (2014) Adverse outcome pathway (AOP) development I: strategies and principles. Toxicol Sci 142(2):312\u2013320. https:\/\/doi.org\/10.1093\/toxsci\/kfu199","journal-title":"Toxicol Sci"},{"key":"4235_CR323","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tox.2013.08.011","volume":"312","author":"M Vinken","year":"2013","unstructured":"Vinken M (2013) The adverse outcome pathway concept: a pragmatic tool in toxicology. Toxicology 312:158\u2013165. https:\/\/doi.org\/10.1016\/j.tox.2013.08.011","journal-title":"Toxicology"},{"key":"4235_CR324","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/978-1-4939-3609-0_14","volume":"1425","author":"M Vinken","year":"2016","unstructured":"Vinken M (2016) Adverse outcome pathways as tools to assess drug-induced toxicity. Methods Mol Biol Clifton NJ 1425:325\u2013337. https:\/\/doi.org\/10.1007\/978-1-4939-3609-0_14","journal-title":"Methods Mol Biol Clifton NJ"},{"key":"4235_CR325","doi-asserted-by":"publisher","first-page":"A1","DOI":"10.1016\/j.tiv.2018.03.017","volume":"50","author":"M Vinken","year":"2018","unstructured":"Vinken M (2018) Taking adverse outcome pathways to the next level. Toxicol Vitro Int J Publ Assoc BIBRA 50:A1\u2013A2. https:\/\/doi.org\/10.1016\/j.tiv.2018.03.017","journal-title":"Toxicol Vitro Int J Publ Assoc BIBRA"},{"key":"4235_CR326","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2024.100504","volume":"40","author":"M Vinken","year":"2024","unstructured":"Vinken M (2024) Adverse outcome pathway networks as the basis for the development of new approach methodologies: Liver toxicity as a case study. Curr Opin Toxicol 40:100504. https:\/\/doi.org\/10.1016\/j.cotox.2024.100504","journal-title":"Curr Opin Toxicol"},{"key":"4235_CR327","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1007\/s00204-018-2297-6","volume":"92","author":"M Vinken","year":"2018","unstructured":"Vinken M, Hengstler JG (2018) Characterization of hepatocyte-based in vitro systems for reliable toxicity testing. Arch Toxicol 92:2981\u20132986. https:\/\/doi.org\/10.1007\/s00204-018-2297-6","journal-title":"Arch Toxicol"},{"key":"4235_CR328","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104786","volume":"117","author":"M Vrolijk","year":"2020","unstructured":"Vrolijk M, Deluyker H, Bast A, de Boer A (2020) Analysis and reflection on the role of the 90-day oral toxicity study in European chemical risk assessment. Regul Toxicol Pharmacol 117:104786. https:\/\/doi.org\/10.1016\/j.yrtph.2020.104786","journal-title":"Regul Toxicol Pharmacol"},{"key":"4235_CR329","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/hep.24148","volume":"53","author":"M Wagner","year":"2011","unstructured":"Wagner M, Zollner G, Trauner M (2011) Nuclear receptors in liver disease. Hepatology 53:1023\u20131034. https:\/\/doi.org\/10.1002\/hep.24148","journal-title":"Hepatology"},{"key":"4235_CR330","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s40572-019-00232-w","volume":"6","author":"B Wahlang","year":"2019","unstructured":"Wahlang B, Jin J, Beier JI et al (2019) Mechanisms of environmental contributions to fatty liver disease. Curr Environ Health Rep 6:80\u201394. https:\/\/doi.org\/10.1007\/s40572-019-00232-w","journal-title":"Curr Environ Health Rep"},{"key":"4235_CR331","doi-asserted-by":"publisher","unstructured":"Walder L, Pallocca G, Bastos LF et al (2025) EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable. ALTEX 42:435\u2013450. https:\/\/doi.org\/10.14573\/altex.2503241","DOI":"10.14573\/altex.2503241"},{"key":"4235_CR332","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.biochi.2013.08.022","volume":"98","author":"RJA Wanders","year":"2014","unstructured":"Wanders RJA (2014) Metabolic functions of peroxisomes in health and disease. Biochimie 98:36\u201344. https:\/\/doi.org\/10.1016\/j.biochi.2013.08.022","journal-title":"Biochimie"},{"key":"4235_CR333","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1016\/j.bmc.2009.01.050","volume":"17","author":"X Wang","year":"2009","unstructured":"Wang X, Lin J, Chen Y et al (2009) Novel fatty acid synthase (FAS) inhibitors: design, synthesis, biological evaluation, and molecular docking studies. Bioorg Med Chem 17:1898\u20131904. https:\/\/doi.org\/10.1016\/j.bmc.2009.01.050","journal-title":"Bioorg Med Chem"},{"issue":"46","key":"4235_CR334","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704039","volume":"27","author":"D Wang","year":"2017","unstructured":"Wang D, Su H, Kwok RTK, Shan G, Leung ACS, Lee MMS, Sung HHY, Williams ID, Lam JWY, Tang BZ (2017) Facile synthesis of Red\/NIR AIE luminogens with simple structures, bright emissions, and high photostabilities, and their applications for specific imaging of lipid droplets and image\u2010guided photodynamic therapy. Adv Funct Mater 27(46):1704039. https:\/\/doi.org\/10.1002\/adfm.201704039","journal-title":"Adv Funct Mater"},{"key":"4235_CR335","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.envpol.2018.12.053","volume":"246","author":"D Wang","year":"2019","unstructured":"Wang D, Yan S, Yan J, Teng M, Meng Z, Li R, Zhou Z, Zhu W (2019a) Effects of triphenyl phosphate exposure during fetal development on obesity and metabolic dysfunctions in adult mice: impaired lipid metabolism and intestinal dysbiosis. Environ Pollut 246:630\u2013638. https:\/\/doi.org\/10.1016\/j.envpol.2018.12.053","journal-title":"Environ Pollut"},{"key":"4235_CR336","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.aca.2019.01.043","volume":"1061","author":"J Wang","year":"2019","unstructured":"Wang J, Wang C, Han X (2019b) Tutorial on lipidomics. Anal Chim Acta 1061:28\u201341. https:\/\/doi.org\/10.1016\/j.aca.2019.01.043","journal-title":"Anal Chim Acta"},{"key":"4235_CR337","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1272540","volume":"14","author":"X Wang","year":"2024","unstructured":"Wang X, Chen Y, Meng H, Meng F (2024) SREBPs as the potential target for solving the polypharmacy dilemma. Front Physiol 14:1272540. https:\/\/doi.org\/10.3389\/fphys.2023.1272540","journal-title":"Front Physiol"},{"key":"4235_CR338","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70243","volume":"39","author":"W Wasityastuti","year":"2025","unstructured":"Wasityastuti W, Tsany SF, Pasaribu HS et al (2025) Sulfo-N-succinimidyl oleate sodium as CD36 inhibitor: dose optimization and its effects on FFA uptake, inflammation, and ER stress in HepG2 cells. J Biochem Mol Toxicol 39:e70243. https:\/\/doi.org\/10.1002\/jbt.70243","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"4235_CR339","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010016","volume":"8","author":"R Weiskirchen","year":"2019","unstructured":"Weiskirchen R, Tacke F (2019) Relevance of autophagy in parenchymal and non-parenchymal liver cells for health and disease. Cells 8(1):16. https:\/\/doi.org\/10.3390\/cells8010016","journal-title":"Cells"},{"key":"4235_CR340","doi-asserted-by":"publisher","first-page":"G1150","DOI":"10.1152\/ajpgi.00456.2004","volume":"288","author":"A Werner","year":"2005","unstructured":"Werner A, Havinga R, Bos T et al (2005) Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles. Am J Physiol Gastrointest Liver Physiol 288:G1150\u2013G1158. https:\/\/doi.org\/10.1152\/ajpgi.00456.2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4235_CR341","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2024.153794","volume":"504","author":"L Wiklund","year":"2024","unstructured":"Wiklund L, P\u00edpal M, Weiss J, Beronius A (2024) Exploring a mechanism-based approach for the identification of endocrine disruptors using adverse outcome pathways (AOPs) and new approach methodologies (NAMs): a perfluorooctane sulfonic acid case study. Toxicology 504:153794. https:\/\/doi.org\/10.1016\/j.tox.2024.153794","journal-title":"Toxicology"},{"key":"4235_CR342","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cmet.2006.01.001","volume":"3","author":"C Wolfrum","year":"2006","unstructured":"Wolfrum C, Stoffel M (2006) Coactivation of Foxa2 through Pgc-1\u03b2 promotes liver fatty acid oxidation and triglyceride\/VLDL secretion. Cell Metab 3:99\u2013110. https:\/\/doi.org\/10.1016\/j.cmet.2006.01.001","journal-title":"Cell Metab"},{"key":"4235_CR343","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1111\/j.1742-4658.2012.08684.x","volume":"279","author":"HR Wurie","year":"2012","unstructured":"Wurie HR, Buckett L, Zammit VA (2012) Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells. FEBS J 279:3033\u20133047. https:\/\/doi.org\/10.1111\/j.1742-4658.2012.08684.x","journal-title":"FEBS J"},{"key":"4235_CR344","doi-asserted-by":"publisher","first-page":"7254","DOI":"10.1021\/bi400914c","volume":"52","author":"S Xu","year":"2013","unstructured":"Xu S, Jay A, Brunaldi K et al (2013) CD36 enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane. Biochemistry 52:7254\u20137261. https:\/\/doi.org\/10.1021\/bi400914c","journal-title":"Biochemistry"},{"key":"4235_CR345","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3389\/fphar.2019.00819","volume":"10","author":"S Xu","year":"2019","unstructured":"Xu S, Chen Y, Ma Y et al (2019) Lipidomic profiling reveals disruption of lipid metabolism in valproic acid-induced hepatotoxicity. Front Pharmacol 10:819. https:\/\/doi.org\/10.3389\/fphar.2019.00819","journal-title":"Front Pharmacol"},{"key":"4235_CR346","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/tox.22562","volume":"33","author":"H Yan","year":"2018","unstructured":"Yan H, Guo H, Cheng D et al (2018) Tributyltin reduces the levels of serum adiponectin and activity of AKT and induces metabolic syndrome in male mice. Environ Toxicol 33:752\u2013758. https:\/\/doi.org\/10.1002\/tox.22562","journal-title":"Environ Toxicol"},{"key":"4235_CR347","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.toxlet.2021.04.016","volume":"346","author":"L Yan","year":"2021","unstructured":"Yan L, Yang K, Wang S et al (2021) PXR-mediated expression of FABP4 promotes valproate-induced lipid accumulation in HepG2 cells. Toxicol Lett 346:47\u201356. https:\/\/doi.org\/10.1016\/j.toxlet.2021.04.016","journal-title":"Toxicol Lett"},{"issue":"1","key":"4235_CR348","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04710-8","volume":"6","author":"J Yang","year":"2023","unstructured":"Yang J, Hirai Y, Iida K, Ito S, Trumm M, Terada S, Sakai R, Tsuchiya T, Tabata O, Kamei K-I (2023a) Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease. Commun Biol 6(1):310. https:\/\/doi.org\/10.1038\/s42003-023-04710-8","journal-title":"Commun Biol"},{"key":"4235_CR349","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108138","volume":"178","author":"W Yang","year":"2023","unstructured":"Yang W, Ling X, He S, Cui H, Yang Z, An H, Wang L, Zou P, Chen Q, Liu J, Ao L, Cao J (2023b) PPAR\u03b1\/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: an integrated approach. Environ Int 178:108138. https:\/\/doi.org\/10.1016\/j.envint.2023.108138","journal-title":"Environ Int"},{"key":"4235_CR350","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.215792","volume":"510","author":"J Yang","year":"2024","unstructured":"Yang J, Ning J, Sun P, Nie Y, Li Y, Guo M, Zhou Y (2024) Fluorescent probes - illuminate the interplay network between lipid droplets and other organelles. Coord Chem Rev 510:215792. https:\/\/doi.org\/10.1016\/j.ccr.2024.215792","journal-title":"Coord Chem Rev"},{"key":"4235_CR351","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1564419","volume":"15","author":"L Yang","year":"2025","unstructured":"Yang L, Liao Z-Z, Ran L, Xiao X-H (2025) Progress of arylacetamide deacetylase research in metabolic diseases. Front Oncol 15:1564419. https:\/\/doi.org\/10.3389\/fonc.2025.1564419","journal-title":"Front Oncol"},{"key":"4235_CR352","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003782","volume":"16","author":"C-H Yao","year":"2018","unstructured":"Yao C-H, Liu G-Y, Wang R et al (2018) Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of \u03b2-oxidation. PLoS Biol 16:e2003782. https:\/\/doi.org\/10.1371\/journal.pbio.2003782","journal-title":"PLoS Biol"},{"key":"4235_CR353","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2011.06.002","volume":"14","author":"JL Yecies","year":"2011","unstructured":"Yecies JL, Zhang HH, Menon S et al (2011) Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 14:21\u201332. https:\/\/doi.org\/10.1016\/j.cmet.2011.06.002","journal-title":"Cell Metab"},{"key":"4235_CR354","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","volume":"19","author":"A Zadoorian","year":"2023","unstructured":"Zadoorian A, Du X, Yang H (2023) Lipid droplet biogenesis and functions in health and disease. Nat Rev Endocrinol 19:443\u2013459. https:\/\/doi.org\/10.1038\/s41574-023-00845-0","journal-title":"Nat Rev Endocrinol"},{"key":"4235_CR355","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1093\/jn\/133.11.3509","volume":"133","author":"KL Zambell","year":"2003","unstructured":"Zambell KL, Fitch MD, Fleming SE (2003) Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells. J Nutr 133:3509\u20133515. https:\/\/doi.org\/10.1093\/jn\/133.11.3509","journal-title":"J Nutr"},{"key":"4235_CR356","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nrm.2017.76","volume":"18","author":"R Zechner","year":"2017","unstructured":"Zechner R, Madeo F, Kratky D (2017) Cytosolic lipolysis and lipophagy: two sides of the same coin. Nat Rev Mol Cell Biol 18:671\u2013684. https:\/\/doi.org\/10.1038\/nrm.2017.76","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4235_CR357","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101428","volume":"57","author":"H Zeng","year":"2021","unstructured":"Zeng H, Qin H, Liao M et al (2021) CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing. Mol Metab 57:101428. https:\/\/doi.org\/10.1016\/j.molmet.2021.101428","journal-title":"Mol Metab"},{"key":"4235_CR358","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.taap.2010.03.016","volume":"245","author":"Y-KJ Zhang","year":"2010","unstructured":"Zhang Y-KJ, Yeager RL, Tanaka Y, Klaassen CD (2010) Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol 245:326\u2013334. https:\/\/doi.org\/10.1016\/j.taap.2010.03.016","journal-title":"Toxicol Appl Pharmacol"},{"key":"4235_CR359","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.aquatox.2015.11.028","volume":"170","author":"J Zhang","year":"2016","unstructured":"Zhang J, Sun P, Kong T, Yang F, Guan W (2016) Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquat Toxicol 170:208\u2013215. https:\/\/doi.org\/10.1016\/j.aquatox.2015.11.028","journal-title":"Aquat Toxicol"},{"issue":"12","key":"4235_CR360","doi-asserted-by":"publisher","first-page":"19541","DOI":"10.1002\/jcb.29262","volume":"120","author":"H Zhang","year":"2019","unstructured":"Zhang H, Wang J, Yang L, Yang W, Luo T, Yuan Y, Gu J, Zou H, Bian J, Liu Z, Liu X (2019a) Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells. J Cell Biochem 120(12):19541\u201319554. https:\/\/doi.org\/10.1002\/jcb.29262","journal-title":"J Cell Biochem"},{"key":"4235_CR361","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2019.06.003","volume":"581","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Mohsen A-W, Kochersperger C, Solo K, Schmidt AV, Vockley J, Goetzman ES (2019b) An acyl-CoA dehydrogenase microplate activity assay using recombinant porcine electron transfer flavoprotein. Anal Biochem 581:113332. https:\/\/doi.org\/10.1016\/j.ab.2019.06.003","journal-title":"Anal Biochem"},{"key":"4235_CR362","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.109611","volume":"184","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L (2019c) Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2\/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicol Environ Saf 184:109611. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109611","journal-title":"Ecotoxicol Environ Saf"},{"issue":"18","key":"4235_CR363","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186714","volume":"28","author":"M Zhang","year":"2023","unstructured":"Zhang M, Bai X, Du Q, Xu J, Wang D, Chen L, Dong K, Chen Z, Yang J (2023) The different mechanisms of lipid accumulation in hepatocytes induced by oleic acid\/palmitic acid and high-fat diet. Molecules 28(18):6714. https:\/\/doi.org\/10.3390\/molecules28186714","journal-title":"Molecules"},{"issue":"1","key":"4235_CR364","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243938","volume":"16","author":"N Zhao","year":"2021","unstructured":"Zhao N, Tan H, Wang L, Han Le, Cheng Y, Feng Y, Li T, Liu X (2021) Palmitate induces fat accumulation via repressing FoxO1-mediated ATGL-dependent lipolysis in HepG2 hepatocytes. PLoS ONE 16(1):e0243938. https:\/\/doi.org\/10.1371\/journal.pone.0243938","journal-title":"PLoS ONE"},{"issue":"11","key":"4235_CR365","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13110802","volume":"13","author":"Q-W Zheng","year":"2021","unstructured":"Zheng Q-W, Ding X-F, Cao H-J, Ni Q-Z, Zhu B, Ma N, Zhang F-K, Wang Y-K, Xu S, Chen T-W, Xia Ji, Qiu X-S, Yu D-Z, Xie D, Li J-J (2021) Ochratoxin A induces steatosis via PPAR\u03b3-CD36 axis. Toxins 13(11):802. https:\/\/doi.org\/10.3390\/toxins13110802","journal-title":"Toxins"},{"key":"4235_CR366","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2023.101813","volume":"78","author":"C Zhou","year":"2023","unstructured":"Zhou C, Ruiz HH, Ling L, Maurizi G, Sakamoto K, Liberini CG, Wang L, Stanley A, Egritag HE, Sanz SM, Lindtner C, Butera MA, Buettner C (2023) Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol-induced hepatic steatosis in rodents. Mol Metab 78:101813. https:\/\/doi.org\/10.1016\/j.molmet.2023.101813","journal-title":"Mol Metab"},{"key":"4235_CR367","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.toxlet.2019.10.010","volume":"319","author":"X-Y Zhu","year":"2020","unstructured":"Zhu X-Y, Xia H-G, Wang Z-H, Li B, Jiang H-Y, Li D-L, Jin R, Jin Y (2020) In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease. Toxicol Lett 319:85\u201394. https:\/\/doi.org\/10.1016\/j.toxlet.2019.10.010","journal-title":"Toxicol Lett"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04235-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-025-04235-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04235-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:02:16Z","timestamp":1772917336000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-025-04235-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":367,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4235"],"URL":"https:\/\/doi.org\/10.1007\/s00204-025-04235-5","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"2 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}