{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:12:19Z","timestamp":1792537939127,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00204-025-04252-4","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T19:19:03Z","timestamp":1765221543000},"page":"1177-1180","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage"],"prefix":"10.1007","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-3266","authenticated-orcid":false,"given":"Hartmut H.","family":"Glossmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"issue":"2","key":"4252_CR1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s00204-024-03912-1","volume":"99","author":"JH Ahn","year":"2025","unstructured":"Ahn JH et al (2025) Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model. Arch Toxicol 99(2):755\u2013773. https:\/\/doi.org\/10.1007\/s00204-024-03912-1","journal-title":"Arch Toxicol"},{"issue":"9","key":"4252_CR2","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41577-022-00694-4","volume":"22","author":"J Amersfoort","year":"2022","unstructured":"Amersfoort J, Eelen G, Carmeliet P (2022) Immunomodulation by endothelial cells: partnering up with the immune system? Nat Rev Immunol 22(9):576\u2013588. https:\/\/doi.org\/10.1038\/s41577-022-00694-4","journal-title":"Nat Rev Immunol"},{"issue":"83","key":"4252_CR3","doi-asserted-by":"publisher","first-page":"eadh3455","DOI":"10.1126\/sciimmunol.adh3455","volume":"8","author":"A Barmada","year":"2023","unstructured":"Barmada A, Klein J, Ramaswamy A, Brodsky NN et al (2023) Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine\u2013associated myocarditis. Sci Immunol 8(83):eadh3455. https:\/\/doi.org\/10.1126\/sciimmunol.adh3455","journal-title":"Sci Immunol"},{"key":"4252_CR4","doi-asserted-by":"publisher","first-page":"114047","DOI":"10.1016\/j.jconrel.2025.114047","volume":"386","author":"SM Bates","year":"2025","unstructured":"Bates SM et al (2025) The kinetics of endosomal disruption reveal differences in lipid nanoparticle-induced cellular toxicity. J Control Release 386:114047. https:\/\/doi.org\/10.1016\/j.jconrel.2025.114047","journal-title":"J Control Release"},{"issue":"13","key":"4252_CR5","doi-asserted-by":"publisher","first-page":"6940","DOI":"10.3390\/ijms23136940","volume":"23","author":"C Baumeier","year":"2022","unstructured":"Baumeier C et al (2022) Intramyocardial inflammation after COVID-19 vaccination: an endomyocardial biopsy-proven case series. Int J Mol Sci 23(13):6940. https:\/\/doi.org\/10.3390\/ijms23136940","journal-title":"Int J Mol Sci"},{"key":"4252_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2978","author":"N Buergin","year":"2023","unstructured":"Buergin N et al (2023) Sex-specific differences in myocardial injury incidence after COVID-19 mRNA-1273 booster vaccination. Eur J Heart Fail. https:\/\/doi.org\/10.1002\/ejhf.2978","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"4252_CR7","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3390\/v15020332","volume":"15","author":"A Bugatti","year":"2023","unstructured":"Bugatti A et al (2023) The D405N mutation in the spike protein of SARS-CoV-2 Omicron BA.5 inhibits spike\/integrin interactions and viral infection of human lung microvascular endothelial cells. Viruses 15(2):332. https:\/\/doi.org\/10.3390\/v15020332","journal-title":"Viruses"},{"issue":"1","key":"4252_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.1983.63.1.1","volume":"63","author":"EO Feigl","year":"1983","unstructured":"Feigl EO (1983) Coronary physiology. Physiol Rev 63(1):1\u2013205. https:\/\/doi.org\/10.1152\/physrev.1983.63.1.1","journal-title":"Physiol Rev"},{"key":"4252_CR500","doi-asserted-by":"publisher","unstructured":"Gregory DJ, Han F, Li P, Gritsenko MA, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS (2024) Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation. Mol Med 30(1):280. https:\/\/doi.org\/10.1186\/s10020-024-01052-x","DOI":"10.1186\/s10020-024-01052-x"},{"key":"4252_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09655-y","author":"AJ Grippin","year":"2025","unstructured":"Grippin AJ et al (2025) SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Nature. https:\/\/doi.org\/10.1038\/s41586-025-09655-y","journal-title":"Nature"},{"issue":"10","key":"4252_CR10","doi-asserted-by":"publisher","first-page":"e0311726","DOI":"10.1371\/journal.pone.0311726","volume":"19","author":"HE Jeon","year":"2024","unstructured":"Jeon HE et al (2024) SARS-CoV-2 mRNA vaccine intravenous administration induces myocarditis in chronic inflammation. PLoS ONE 19(10):e0311726. https:\/\/doi.org\/10.1371\/journal.pone.0311726","journal-title":"PLoS ONE"},{"issue":"39","key":"4252_CR11","doi-asserted-by":"publisher","first-page":"27077","DOI":"10.1021\/acsnano.4c11652","volume":"18","author":"SJ Kent","year":"2024","unstructured":"Kent SJ et al (2024) Blood distribution of SARS-CoV-2 lipid nanoparticle mRNA vaccine in humans. ACS Nano 18(39):27077\u201327089. https:\/\/doi.org\/10.1021\/acsnano.4c11652","journal-title":"ACS Nano"},{"issue":"11","key":"4252_CR12","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1093\/cid\/ciab707","volume":"74","author":"C Li","year":"2022","unstructured":"Li C et al (2022a) Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in a mouse model. Clinic Infect Diseases 74(11):1933\u20131950. https:\/\/doi.org\/10.1093\/cid\/ciab707","journal-title":"Clinic Infect Diseases"},{"key":"4252_CR13","doi-asserted-by":"publisher","first-page":"21690","DOI":"10.1038\/s41598-022-21690-7","volume":"12","author":"X Li","year":"2022","unstructured":"Li X et al (2022b) A comparative study of SARS-CoV-2 WT versus Omicron (B.1.1.529) spike on innate immune activation. Sci Rep 12:21690. https:\/\/doi.org\/10.1038\/s41598-022-21690-7","journal-title":"Sci Rep"},{"issue":"7","key":"4252_CR14","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1161\/ATVBAHA.112.251181","volume":"32","author":"Z Lu","year":"2012","unstructured":"Lu Z et al (2012) Toll-like receptor 4 activation in microvascular endothelial cells triggers a robust inflammatory response and cross-talk with mononuclear cells via interleukin-6. Arterioscler Thromb Vasc Biol 32(7):1696\u20131706. https:\/\/doi.org\/10.1161\/ATVBAHA.112.251181","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4252_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02528-1","author":"J Luo","year":"2025","unstructured":"Luo J et al (2025) Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning. Nat Biotechnol. https:\/\/doi.org\/10.1038\/s41587-024-02528-1","journal-title":"Nat Biotechnol"},{"issue":"8","key":"4252_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3390\/tropicalmed7080196","volume":"7","author":"S Mansanguan","year":"2022","unstructured":"Mansanguan S et al (2022) Cardiovascular manifestations of the BNT162b2 mRNA COVID-19 vaccine in adolescents. Tropical Med Infect Disease 7(8):196. https:\/\/doi.org\/10.3390\/tropicalmed7080196","journal-title":"Tropical Med Infect Disease"},{"issue":"1","key":"4252_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1161\/01.CIR.86.1.38","volume":"86","author":"K Rakusan","year":"1992","unstructured":"Rakusan K et al (1992) Morphometry of human coronary capillaries during normal growth and the effect of age in left ventricular pressure-overload hypertrophy. Circulation 86(1):38\u201346. https:\/\/doi.org\/10.1161\/01.CIR.86.1.38","journal-title":"Circulation"},{"issue":"8","key":"4252_CR18","doi-asserted-by":"publisher","first-page":"mjac058","DOI":"10.1093\/jmcb\/mjac058","volume":"14","author":"F Samsudin","year":"2022","unstructured":"Samsudin F et al (2022) SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade. J Mol Cell Biol 14(8):mjac058. https:\/\/doi.org\/10.1093\/jmcb\/mjac058","journal-title":"J Mol Cell Biol"},{"key":"4252_CR19","doi-asserted-by":"publisher","first-page":"e17923","DOI":"10.1038\/s44320-025-00093-6","volume":"17","author":"A Simonis","year":"2025","unstructured":"Simonis A, Theobald SJ, Zelcovsky A, Reinartz D, Drosten C (2025) Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages. EMBO Mol Med 17:e17923. https:\/\/doi.org\/10.1038\/s44320-025-00093-6","journal-title":"EMBO Mol Med"},{"issue":"8","key":"4252_CR20","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3390\/vaccines13080855","volume":"13","author":"J Szebeni","year":"2025","unstructured":"Szebeni J, Koller A (2025) Multisystem endothelial inflammation: a key driver of adverse events following mRNA-containing COVID-19 vaccines. Vaccines 13(8):855. https:\/\/doi.org\/10.3390\/vaccines13080855","journal-title":"Vaccines"},{"key":"4252_CR501","doi-asserted-by":"publisher","unstructured":"Zelkoski AE, Lu Z, Sukumar G, Dalgard C, Said H, Alameh MG, Mitre E, Malloy AMW (2025) Ionizable lipid nanoparticles of mRNA vaccines elicit NF-\u03baB and IRF responses through toll-like receptor 4. NPJ Vaccines 10(1):73. https:\/\/doi.org\/10.1038\/s41541-025-01124-x","DOI":"10.1038\/s41541-025-01124-x"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04252-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-025-04252-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04252-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T08:56:44Z","timestamp":1772873804000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-025-04252-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4252"],"URL":"https:\/\/doi.org\/10.1007\/s00204-025-04252-4","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"7 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}