{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:52:49Z","timestamp":1772938369556,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00204-025-04253-3","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T19:18:32Z","timestamp":1765221512000},"page":"1171-1175","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pheochromocytoma in rats: a weak link in the assessment of talc carcinogenicity?"],"prefix":"10.1007","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-3823","authenticated-orcid":false,"given":"Andrey A.","family":"Korchevskiy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"issue":"2","key":"4253_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.14744\/SEMB.2020.18794","volume":"54","author":"N Aygun","year":"2020","unstructured":"Aygun N, Uludag M (2020) Pheochromocytoma and paraganglioma: from epidemiology to clinical findings. Sisli Etfal Hastan Tip Bul 54(2):159\u2013168. https:\/\/doi.org\/10.14744\/SEMB.2020.18794","journal-title":"Sisli Etfal Hastan Tip Bul"},{"issue":"4","key":"4253_CR2","doi-asserted-by":"publisher","first-page":"e230466","DOI":"10.1530\/EC-23-0466","volume":"13","author":"SML Burciulescu","year":"2024","unstructured":"Burciulescu SML, Gheorghiu ML, Muresan A, Gherlan I, Patocs A, Badiu C (2024) Bilateral pheochromocytomas: clinical presentation and morbidity rate related to surgery technique and genetic status. Endocr Connect 13(4):e230466. https:\/\/doi.org\/10.1530\/EC-23-0466","journal-title":"Endocr Connect"},{"key":"4253_CR3","unstructured":"ECHA\/RCA European Chemicals Agency, Committee for Risk Assessment (RAC) (2025) Opinion proposing harmonized classification and labelling at EU level of Talc (Mg3H2(SiO3)4). EC Number: 238-877-9; CAS Number: 14807-96-6; CLH-O-0000007513-76-01\/F. Adopted 20 Sept 2024; Published 09 Jul 2025"},{"issue":"2","key":"4253_CR4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1164\/rccm.202407-1376rl","volume":"211","author":"AJ Ghio","year":"2024","unstructured":"Ghio AJ (2024) Talc, pleurodesis, and cancer. Am J Respir Crit Care Med 211(2):295\u2013296. https:\/\/doi.org\/10.1164\/rccm.202407-1376rl","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"4253_CR5","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1080\/10408440903190861","volume":"39","author":"H Greim","year":"2009","unstructured":"Greim H, Hartwig A, Reuter U, Richter-Reichhelm HB, Thielmann HW (2009) Chemically induced pheochromocytomas in rats: mechanisms and relevance for human risk assessment. Crit Rev Toxicol 39(8):695\u2013718. https:\/\/doi.org\/10.1080\/10408440903190861","journal-title":"Crit Rev Toxicol"},{"key":"4253_CR6","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1177\/019262339802600318","volume":"26","author":"JK Haseman","year":"1998","unstructured":"Haseman JK, Hailey JR, Morris RW (1998) Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National toxicology program update. Toxicol Pathol 26:428\u2013441. https:\/\/doi.org\/10.1177\/019262339802600318","journal-title":"Toxicol Pathol"},{"key":"4253_CR7","unstructured":"IARC International Agency for Research on Cancer (2010) Carbon black, titanium dioxide, and talc. In: IARC Working group on the evaluation of carcinogenic risks to humans, vol 9. Lyon February 7\u201314, 2006"},{"key":"4253_CR300","unstructured":"IARC (International Agency for Research on Cancer) (2019) IARC Monographs on the Identification of Carcinogenic Hazards toHumans. Preamble. Lyon, France. Amended January 2019"},{"key":"4253_CR8","unstructured":"IARC International Agency for Research on Cancer (2025) Talc and Acrylonitrile. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. vol 136. Advance publication, 30 June 2025"},{"issue":"12","key":"4253_CR9","doi-asserted-by":"publisher","first-page":"e0168413","DOI":"10.1371\/journal.pone.0168413","volume":"11","author":"KY Kim","year":"2016","unstructured":"Kim KY, Kim JH, Hong AR, Seong MW, Lee KE, Kim SJ, Kim SW, Shin CS, Kim SY (2016) Disentangling of malignancy from benign pheochromocytomas\/paragangliomas. PLoS ONE 11(12):e0168413. https:\/\/doi.org\/10.1371\/journal.pone.0168413","journal-title":"PLoS ONE"},{"issue":"3","key":"4253_CR10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0272-0590(88)90284-9","volume":"10","author":"PE Morrow","year":"1988","unstructured":"Morrow PE (1988) Possible mechanisms to explain dust overloading of the lungs. Fundam Appl Toxicol 10(3):369\u2013384. https:\/\/doi.org\/10.1016\/0272-0590(88)90284-9","journal-title":"Fundam Appl Toxicol"},{"key":"4253_CR11","unstructured":"[NTP] National Toxicology Program (1993) NTP toxicology and carcinogenesis studies of Talc (CAS 14807-96-6)(Non-Asbestiform) in F344\/N rats and B6C3F1 mice (Inhalation studies). NTP TR 421. September 1993"},{"issue":"2","key":"4253_CR12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1006\/rtph.1995.1034","volume":"21","author":"G Oberd\u00f6rster","year":"1995","unstructured":"Oberd\u00f6rster G (1995) The NTP Talc inhalation study: a critical appraisal focused on lung particle overload. Reg Toxicol Pharmacol 21(2):233\u2013241. https:\/\/doi.org\/10.1006\/rtph.1995.1034","journal-title":"Reg Toxicol Pharmacol"},{"issue":"2","key":"4253_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/019262302753559605","volume":"30","author":"K Ozaki","year":"2002","unstructured":"Ozaki K, Haseman JK, Hailey JR, Maronpot RR, Nyska A (2002) Association of adrenal pheochromocytoma and lung pathology in inhalation studies with particulate compounds in the male F344 rat\u2013the National toxicology program experience. Toxicol Pathol 30(2):263\u2013270. https:\/\/doi.org\/10.1080\/019262302753559605","journal-title":"Toxicol Pathol"},{"key":"4253_CR14","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/bjc.1980.70","volume":"41","author":"IF Purchase","year":"1980","unstructured":"Purchase IF (1980) Inter-species comparisons of carcinogenicity. Br J Cancer 41:454\u2013468. https:\/\/doi.org\/10.1038\/bjc.1980.70","journal-title":"Br J Cancer"},{"issue":"1","key":"4253_CR15","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0027-5107(93)90006-2","volume":"286","author":"RW Tennant","year":"1993","unstructured":"Tennant RW (1993) Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard. Mutat Res 286(1):111\u2013118. https:\/\/doi.org\/10.1016\/0027-5107(93)90006-2","journal-title":"Mutat Res"},{"issue":"1","key":"4253_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/toxsci\/51.1.9","volume":"51","author":"AS Tischler","year":"1999","unstructured":"Tischler AS, Powers JF, Pignatello M, Tsokas P, Downing JC, McClain RM (1999) Vitamin D3-induced proliferative lesions in the rat adrenal medulla. Toxicol Sci 51(1):9\u201318. https:\/\/doi.org\/10.1093\/toxsci\/51.1.9","journal-title":"Toxicol Sci"},{"issue":"8","key":"4253_CR17","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1111\/bcp.15790","volume":"89","author":"JW Van der Laan","year":"2023","unstructured":"Van der Laan JW, Andersson M, Beken S, Bonelli M, Brendler-Schwaab S et al (2023) EMA commentary on the ICH guideline for testing for carcinogenicity of pharmaceuticals. Br J Clin Pharmacol 89(8):2341\u20132348. https:\/\/doi.org\/10.1111\/bcp.15790","journal-title":"Br J Clin Pharmacol"},{"key":"4253_CR19","doi-asserted-by":"publisher","unstructured":"Warheit DB, Kreiling R, Levy LS (2016) Toxicology relevance of the rat lung tumor response to particle overload for human risk assessment-Update and interpretation of new data since ILSI 2000 374:42\u201359. https:\/\/doi.org\/10.1016\/j.tox.2016.11.013","DOI":"10.1016\/j.tox.2016.11.013"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04253-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-025-04253-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-025-04253-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T08:56:48Z","timestamp":1772873808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-025-04253-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4253"],"URL":"https:\/\/doi.org\/10.1007\/s00204-025-04253-3","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"11 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Andrey Korchevskiy is a co-owner and salaried employee of Chemistry & Industrial Hygiene, Inc. (Lakewood, Colorado). He has participated as an expert and\/or consultant in litigation related to asbestos and talc exposures. In general, no time for the writing of this letter was billed to any clients of the authors. No copies of the letter were provided to any clients prior to publication. No feedback or comments were received from any party outside of the authorship team during the preparation of the letter. The letter reflects only opinions of the author and not the organization he represents. Debbie Vaughan performed only administrative tasks and helped to organize references in this letter. She performs different tasks as a researcher for projects with various clients of C&IH, but she has never communicated any information about this letter to any client(s).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}