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Ltd. The other authors declare they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted in accordance with relevant institutional and national guidelines and were approved by the Animal Care and Use Committee of Chiba University (approval numbers: 6-212, 7-94, and 8-170). This manuscript does not contain clinical studies or patient data.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}