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Its toxicological effects are closely tied to its structural characteristics, particularly its weak acid nature and strong metal-chelating ability, with iron being a critical target. By disrupting iron homeostasis, FA contributes to oxidative stress by enhancing reactive oxygen species (ROS) production and modulating antioxidant defence pathways. Furthermore, FA\u2019s interaction with iron positions it as a potential regulator of ferritinophagy and ferroptosis, two interconnected processes that link iron metabolism to cellular survival and death. Although FA has been associated with other cellular pathways, its precise role in iron-dependent pathways remains insufficiently defined. This review seeks to consolidate current knowledge on FA, emphasising its iron-chelating properties and their impact on iron-dependent mechanisms, including oxidative stress, ferritinophagy, and ferroptosis.\n                  <\/jats:p>","DOI":"10.1007\/s00204-026-04553-2","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:14:14Z","timestamp":1789816454000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of fusaric acid on oxidative stress, ferritinophagy, and ferroptosis pathways: a review"],"prefix":"10.1007","author":[{"given":"Anthia C.","family":"Govender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-213X","authenticated-orcid":false,"given":"Terisha","family":"Ghazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"4553_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/143636","volume":"2015","author":"D Ayers","year":"2015","unstructured":"Ayers D, Baron B, Hunter T (2015) miRNA influences in NRF2 pathway interactions within cancer models. 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