{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:37:46Z","timestamp":1759333066583},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[1994,1]]},"DOI":"10.1007\/s002040050025","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T07:30:30Z","timestamp":1030260630000},"page":"24-31","source":"Crossref","is-referenced-by-count":39,"title":["Metabolic alterations in hepatocytes promoted by the herbicides paraquat, dinoseb and 2,4-D"],"prefix":"10.1007","volume":"68","author":[{"given":"C. M.","family":"Palmeira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. M. C.","family":"Madeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"40680015204_CR1","doi-asserted-by":"crossref","first-page":"C385","DOI":"10.1152\/ajpcell.1985.249.5.C385","volume":"249","author":"TY Aw","year":"1985","unstructured":"Aw TY, Jones DP (1985) ATP concentration gradient in cytosol of liver cells during hypoxia. Am J Physiol 249: C385-C392","journal-title":"Am J Physiol"},{"key":"40680015204_CR2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1021\/ar00009a003","volume":"24","author":"TA Baillie","year":"1991","unstructured":"Baillie TA, Slatter JG (1991) Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo. Accounts of Chemical Research 24: 264\u2013270","journal-title":"Accounts of Chemical Research"},{"key":"40680015204_CR3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/hep.1840050529","volume":"5","author":"G Bellomo","year":"1985","unstructured":"Bellomo G, Orrenius S (1985) Altered thiol and calcium homeostasis in oxidative hepatocellular injury. Hepatology 5: 876\u2013882","journal-title":"Hepatology"},{"key":"40680015204_CR4","first-page":"275","volume":"10","author":"AR Boobis","year":"1989","unstructured":"Boobis AR, Fawthrop DJ, Davies DS (1989) Mechanisms of cell death. TIPS 10: 275\u2013280","journal-title":"TIPS"},{"key":"40680015204_CR5","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(82)90393-8","volume":"31","author":"R Brigelius","year":"1982","unstructured":"Brigelius R, Lenzen R, Sies H (1982) Increase in hepatic mixed disulphide and glutathione disulphide levels elicited by paraquat. Biochem Pharmacol 31: 1637\u20131641","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-2952(83)90667-6","volume":"32","author":"E Cadenas","year":"1983","unstructured":"Cadenas E, Brigelius R, Sies H (1983) Paraquat-induced chemiluminescence of microsomal fractions. Biochem Pharmacol 32: 147\u2013150","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR7","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1016\/0006-2952(87)90021-9","volume":"36","author":"AF Casini","year":"1987","unstructured":"Casini AF, Maellaro E, Pompella A, Ferrali M, Comporti M (1987) Lipid peroxidation proteins thiols and calcium homeostasis in bromobenzene-induced liver damage. Biochem Pharmacol 36: 3689\u20133695","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0940-2993(11)80202-2","volume":"44","author":"R Dargel","year":"1992","unstructured":"Dargel R (1992) Lipid peroxidation\u2014a common pathogenetic mechanism? Exp Toxicol Pathol 44: 169\u2013181","journal-title":"Exp Toxicol Pathol"},{"key":"40680015204_CR9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0003-9861(91)90454-Q","volume":"289","author":"JA DeGray","year":"1991","unstructured":"DeGray JA, Rao DNR, Mason RP (1991) Reduction of paraquat and related bipyridylium compounds to free radical metabolites by rat hepatocytes. Arch Biochem Biophys 289: 145\u2013152","journal-title":"Arch Biochem Biophys"},{"key":"40680015204_CR10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0163-7258(91)90029-L","volume":"52","author":"LD DeLeve","year":"1991","unstructured":"DeLeve LD, Kaplowitz N (1991) Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52: 287\u2013305","journal-title":"Pharmacol Ther"},{"key":"40680015204_CR11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0003-9861(84)90206-6","volume":"235","author":"D DiMonte","year":"1984","unstructured":"DiMonte D, Ross D, Bellomo G, Eklow L, Orrenius S (1984) Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch Biochem Biophys 235: 334\u2013342","journal-title":"Arch Biochem Biophys"},{"key":"40680015204_CR12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0006-291X(86)91211-8","volume":"137","author":"D DiMonte","year":"1986","unstructured":"DiMonte D, Jewell SA, Ekstrom G, Sandy MS, Smith MT (1986) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes. Biochem Biophys Res Commun 137: 310\u2013315","journal-title":"Biochem Biophys Res Commun"},{"key":"40680015204_CR13","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/0006-2952(90)90603-I","volume":"39","author":"IA Donatus","year":"1990","unstructured":"Donatus IA, Sardjoko, Vermeulen NPE (1990) Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes. Biochem Pharmacol 39: 1869\u20131875","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF01977355","volume":"65","author":"DJ Fawthrop","year":"1991","unstructured":"Fawthrop DJ, Boobis AR, Davies DS (1991) Mechanisms of cell death. Arch Toxicol 65: 437\u2013444","journal-title":"Arch Toxicol"},{"key":"40680015204_CR15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/BF01981506","volume":"66","author":"S Ghatineh","year":"1992","unstructured":"Ghatineh S, Morgan W, Preece NE, Timbrell JA (1992) A biochemical and NMR spectroscopic study of hydrazine in the isolated hepatocyte. Arch Toxicol 66: 660\u2013668","journal-title":"Arch Toxicol"},{"key":"40680015204_CR16","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0003-9861(86)90305-X","volume":"246","author":"B Halliwell","year":"1986","unstructured":"Halliwell B, Gutteridge JC (1986) Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 246: 501\u2013514","journal-title":"Arch Biochem Biophys"},{"key":"40680015204_CR17","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.2042-7158.1991.tb03468.x","volume":"43","author":"S Hara","year":"1991","unstructured":"Hara S, Endo T, Kurriwa F, Kano S (1991) Mechanism of paraquat-stimulated lipid peroxidation in mouse brain and pulmonary microsomes. J Pharm Pharmacol 43: 731\u2013733","journal-title":"J Pharm Pharmacol"},{"key":"40680015204_CR18","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0006-2952(91)90648-O","volume":"41","author":"AW Harman","year":"1991","unstructured":"Harman AW, Kyle ME, Serroni A, Farber JL (1991) The killing of cultured hepatocytes by n-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen. Biochem Pharmacol 41: 1111\u20131117","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR19","first-page":"214","volume":"74","author":"PJ Hissin","year":"1976","unstructured":"Hissin PJ, Hilf R (1976) A fluorometric method for the determination of oxidized and reduced glutathione in tissues. Anal Chem 74: 214\u2013220","journal-title":"Anal Chem"},{"key":"40680015204_CR20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1432-1033.1977.tb11368.x","volume":"74","author":"J Hogberg","year":"1977","unstructured":"Hogberg J, Kristoferson A (1977) A correlation between glutathione levels and cellular damage in isolated hepatocytes. Eur J Biochem 74: 77\u201382","journal-title":"Eur J Biochem"},{"key":"40680015204_CR21","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0006-2952(91)90299-K","volume":"42","author":"JA Holme","year":"1991","unstructured":"Holme JA, Hongslo JK, Bjorge C, Nelson SD (1991) Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes. Biochem Pharmacol 42: 1137\u20131142","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR22","doi-asserted-by":"crossref","first-page":"C663","DOI":"10.1152\/ajpcell.1986.250.5.C663","volume":"250","author":"DP Jones","year":"1986","unstructured":"Jones DP (1986) Intracellular diffusion gradients of O2 and ATP. Am J Physiol 250: C663-C675","journal-title":"Am J Physiol"},{"key":"40680015204_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-2952(86)90544-7","volume":"35","author":"H Kappus","year":"1986","unstructured":"Kappus H (1986) Overview of enzyme systems involved in bio-reduction of drugs and in redox cycling. Biochem Pharmacol 35: 1\u20136","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR24","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/S0021-9258(19)77964-2","volume":"263","author":"J Krall","year":"1988","unstructured":"Krall J, Bagley AC, Mullenbach GT, Hallewell RA, Lynch RE (1988) Superoxide mediates the toxicity of paraquat for cultured mammalian cells. J Biol Chem 263: 1910\u20131914","journal-title":"J Biol Chem"},{"key":"40680015204_CR25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1432-1033.1982.tb07014.x","volume":"129","author":"N Kraus-Friedman","year":"1982","unstructured":"Kraus-Friedman N, Biber J, Muren H, Carafoli E (1982) Calcium uptake in isolated hepatic plasma membrane vesicles. Eur J Biochem 129: 7\u201312","journal-title":"Eur J Biochem"},{"key":"40680015204_CR26","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/0006-2952(90)90370-Z","volume":"40","author":"ED Kroese","year":"1990","unstructured":"Kroese ED, Bannenberg G, Dogterom P, Noach ABJ, Nagelkerke JF, Meerman JHN (1990) Lipid peroxidation and protein thiol depletion are not involved in the cytotoxicity of N-hydroxy-2-acetylaminofluorene in isolated rat hepatocytes. Biochem Pharmacol 40: 1885\u20131892","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/325078a0","volume":"325","author":"JJ Lemasters","year":"1987","unstructured":"Lemasters JJ, DiGiuseppi J, Nieminen A-L, Herman B (1987) Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes. Nature 325: 78\u201381","journal-title":"Nature"},{"key":"40680015204_CR28","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/0006-2952(90)90515-M","volume":"39","author":"E Maellaro","year":"1990","unstructured":"Maellaro E, Casini AF, Del Bello B, Comporti M (1990) Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents. Biochem Pharmacol 39: 1513\u20131521","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR29","first-page":"60","volume-title":"Methods in enzymology","author":"P Mold\u00e9us","year":"1978","unstructured":"Mold\u00e9us P, Hogberg J, Orrenius S (1978) Isolation and use of liver cells. In: Fleischer S, Packer L (eds) Methods in enzymology, vol 52, Academic Press, New York, pp 60\u201371"},{"key":"40680015204_CR30","first-page":"159","volume":"43","author":"Y Nakagawa","year":"1992","unstructured":"Nakagawa Y, Mold\u00e9us P, Moore GA (1992) Cytotoxicity of ortho-phenylphenol in isolated rat hepatocytes. Biochem Pharmacol 43: 159\u2013165","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1096\/fasebj.3.1.2910738","volume":"3","author":"P Nicotera","year":"1989","unstructured":"Nicotera P, Thor H, Orrenius S (1989) Cytosolic-free Ca2+ and cell killing in hepatoma lclc7 cells exposed to chemical anoxia. FASEB J 3: 59\u201364","journal-title":"FASEB J"},{"key":"40680015204_CR32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0143-4160(88)90004-8","volume":"9","author":"AL Nieminen","year":"1988","unstructured":"Nieminen AL, Gores GJ, Wray BE, Tanaka Y, Herman B, Lemasters JJ (1988) Calcium dependence of bleb formation and cell death in hepatocytes. Cell Calcium 9: 237\u2013246","journal-title":"Cell Calcium"},{"issue":"supplement","key":"40680015204_CR33","first-page":"15","volume":"6","author":"S Orrenius","year":"1985","unstructured":"Orrenius S (1985) Biochemical mechanisms of cytotoxicity. TIPS 6 [FEST supplement]: 15\u201320","journal-title":"TIPS"},{"key":"40680015204_CR34","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0006-2952(92)90234-A","volume":"43","author":"B Peter","year":"1992","unstructured":"Peter B, Wartena M, Kampinga HH, Konings WT (1992) Role of lipid peroxidation and DNA damage in paraquat toxicity and the interaction of paraquat with ionizing radiation. Biochem Pharmacol 43: 705\u2013715","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0003-9861(89)90181-1","volume":"273","author":"FAM Redegeld","year":"1989","unstructured":"Redegeld FAM, Moison RMW, Koster ASJ, Noordhoek J (1989) Alterations in energy status by menadione metabolism in hepatocytes from fasted and fed rats. Arch Biochem Biophys 273: 215\u2013222","journal-title":"Arch Biochem Biophys"},{"key":"40680015204_CR36","first-page":"25S","volume":"36","author":"DJ Reed","year":"1984","unstructured":"Reed DJ, Fariss MW (1984) Glutathione depletion and susceptibility. Pharmacol Rev 36: 25S-33S","journal-title":"Pharmacol Rev"},{"key":"40680015204_CR37","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1016\/0006-2952(88)90318-8","volume":"37","author":"FA Reitman","year":"1988","unstructured":"Reitman FA, Shertzer HG, Berger ML (1988) Toxicity of methylating agents in isolated hepatocytes. Biochem Pharmacol 37: 3183\u20133188","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR38","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/0006-2952(86)90392-8","volume":"35","author":"MS Sandy","year":"1986","unstructured":"Sandy MS, Moldeus P, Ross D, Smith MT (1986) Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity. Studies with a compromised isolated hepatocyte model system. Biochem Pharmacol 35: 3095\u20133101","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0003-9861(91)90416-G","volume":"289","author":"JM Silva","year":"1991","unstructured":"Silva JM, McGirr L, O'Brien P (1991) Prevention of nitrofurantoininduced cytotoxicity in isolated hepatocytes by fructose. Arch Biochem Biophys. 289: 313\u2013318","journal-title":"Arch Biochem Biophys"},{"key":"40680015204_CR40","first-page":"944","volume":"249","author":"PF Smith","year":"1989","unstructured":"Smith PF, Hoke GD, Alberts DW, Bugelski PJ, Lupo S, Mirabelli CKM, Rush G (1989) Mechanism of toxicity of an experimental bidentate phosphine gold complexed antineoplastic agent in isolated rat hepatocytes. J Pharmacol Exp Ther 249: 944\u2013950","journal-title":"J Pharmacol Exp Ther"},{"key":"40680015204_CR41","first-page":"1317","volume-title":"Handbook of pesticide toxicology, vol 3","author":"JT Stevens","year":"1991","unstructured":"Stevens JT, Sumner DD (1991) Herbicides. In: Hayes WJ, Laws ER (eds) Handbook of pesticide toxicology, vol 3, Academic Press, New York, pp 1317\u20131391."},{"key":"40680015204_CR42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0003-2697(85)90405-1","volume":"146","author":"V Stocchi","year":"1985","unstructured":"Stocchi V, Cucchiarini L, Magnani M, Chiarantini L, Palma P, Crescentini G (1985) Simultaneous extraction and reverse-phase highperformance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells. Anal Biochem 146: 118\u2013124","journal-title":"Anal Biochem"},{"key":"40680015204_CR43","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/0006-2952(92)90076-U","volume":"44","author":"ZE Suntres","year":"1992","unstructured":"Suntres ZE, Hepworth SR, Shek PN (1992) Protective effect of liposome-associated \u03b1-tocopherol against paraquat-induced acute lung toxicity. Biochem Phamacol 44: 1811\u20131818","journal-title":"Biochem Phamacol"},{"key":"40680015204_CR44","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/0006-2952(88)90582-5","volume":"37","author":"D Thompson","year":"1988","unstructured":"Thompson D, Mold\u00e9us P (1988) Cytotoxicity of butylated hydroxyanisole and butylated hydroxytoluene in isolated rat hepatocytes. Biochem Pharmacol 37: 2201\u20132207","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR45","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/0006-2952(87)90132-8","volume":"36","author":"R Straat Van de","year":"1987","unstructured":"Van de Straat R, de Vries, J, Debets AJJ, Vermeulen NPE (1987) The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress. Biochem Pharmacol 36: 2065\u20132070","journal-title":"Biochem Pharmacol"},{"key":"40680015204_CR46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0891-5849(90)90120-8","volume":"9","author":"LA Videla","year":"1990","unstructured":"Videla LA, Barros SB, Junqueira VBC (1990) Lindane-induced liver oxidative stress. Free Rad Biol Med 9: 169\u2013179","journal-title":"Free Rad Biol Med"},{"key":"40680015204_CR47","first-page":"75","volume-title":"The pesticide book","author":"GW Ware","year":"1978","unstructured":"Ware GW (1978) Chemicals used in the control of plants. In: The pesticide book. WH Freeman, San Franscisco, pp 75\u201394"},{"key":"40680015204_CR48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0891-5849(91)90182-3","volume":"11","author":"H Zer","year":"1991","unstructured":"Zer H, Freedman JH, Peisach J, Chevion M (1991) Inverse correlation between resistance towards copper and towards the redox-cycling compound paraquat: a study in copper-tolerant hepatocytes in tissue culture. Free Rad Biol Med 11: 9\u201316","journal-title":"Free Rad Biol Med"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002040050025\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T11:24:55Z","timestamp":1620041095000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s002040050025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["40680015204"],"URL":"https:\/\/doi.org\/10.1007\/s002040050025","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}