{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:53:15Z","timestamp":1785711195520,"version":"3.56.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[1994,3]]},"DOI":"10.1007\/s002040050054","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T07:30:30Z","timestamp":1030260630000},"page":"193-202","source":"Crossref","is-referenced-by-count":30,"title":["Sensory irritation and pulmonary irritation of n-methyl ketones: receptor activation mechanisms and relationships with threshold limit values"],"prefix":"10.1007","volume":"68","author":[{"given":"Lea Frimann","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar Damg\u00e5rd","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"40680193204_CR1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/qsar.19900090103","volume":"9","author":"MH Abraham","year":"1990","unstructured":"Abraham MH, Whiting GS, Alarie Y, Morris JJ, Taylor PJ, Doherty RM, Taft RW, Nielsen GD (1990) Hydrogen bonding 12. A new QSAR for upper respiratory tract irritation by airborne chemicals in mice. Quant Struct-Act Relat 9: 6\u201310","journal-title":"Quant Struct-Act Relat"},{"key":"40680193204_CR2","volume-title":"Threshold limit values and biological exposure indices for 1991\u20131992","author":"ACGIH","year":"1991","unstructured":"ACGIH (1991) Threshold limit values and biological exposure indices for 1991\u20131992. American Conference of Governmental Industrial Hygienists, Cincinnati"},{"key":"40680193204_CR3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/10408447309082020","volume":"2","author":"Y Alarie","year":"1973","unstructured":"Alarie Y (1973) Sensory irritation by airborne chemicals. CRC Crit Rev Toxicol 2: 299\u2013363","journal-title":"CRC Crit Rev Toxicol"},{"key":"40680193204_CR4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1289\/ehp.81429","volume":"42","author":"Y Alarie","year":"1981","unstructured":"Alarie Y (1981a) Dose-response analysis in animal studies; prediction of human responses. Environ Health Perspect 42: 9\u201313.","journal-title":"Environ Health Perspect"},{"key":"40680193204_CR5","series-title":"Proceedings of the inhalation toxicology and technology symposium","first-page":"207","volume-title":"Toxicological evaluation of airborne chemical irritants and allergens using respiratory reflex reactions","author":"Y Alarie","year":"1981","unstructured":"Alarie Y (1981b) Toxicological evaluation of airborne chemical irritants and allergens using respiratory reflex reactions. In: Leong BKJ (ed) Proceedings of the inhalation toxicology and technology symposium. Ann Arbor Science Publishers, Collingwood, pp 207\u2013231"},{"key":"40680193204_CR6","volume-title":"Standard test method for estimating sensory irritancy of airborne chemicals","author":"ASTM","year":"1984","unstructured":"ASTM (1984) Standard test method for estimating sensory irritancy of airborne chemicals. American Society for Testing and Materials. Philadelphia, designation: E981\u201384"},{"key":"40680193204_CR7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0378-4274(81)90030-8","volume":"9","author":"J Ceaurriz de","year":"1981","unstructured":"Ceaurriz J de, Micillino JC, Bonnet P, Guenier JP (1981) Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett 9: 137\u2013143","journal-title":"Toxicol Lett"},{"key":"40680193204_CR8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0278-6915(84)90225-4","volume":"22","author":"J Ceaurriz de","year":"1984","unstructured":"Ceaurriz J de, Micillino JC, Marignac B, Bonnet P, Muller J, Guenier JP (1984) Quantitative evaluation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice. Food Chem Toxicol 22: 545\u2013549","journal-title":"Food Chem Toxicol"},{"key":"40680193204_CR9","volume-title":"Lectures on biostatistics","author":"D Colquhoun","year":"1971","unstructured":"Colquhoun D (1971) Lectures on biostatistics. Clarendon Press, Oxford"},{"key":"40680193204_CR10","unstructured":"Douglas RB (1974) Human reflex bronchoconstriction as an adjunct to conjunctival sensitivity in defining the threshold limit values of irritant gases and vapours. Thesis, TUC Centenary Institute of Occupational Health London School of Hygiene and Tropical Medicine, University of London"},{"key":"40680193204_CR11","doi-asserted-by":"crossref","DOI":"10.1515\/9783112706992","volume-title":"Theoretical drug design methods","author":"R Franke","year":"1984","unstructured":"Franke R (1984) Theoretical drug design methods. Elsevier, Amsterdam"},{"key":"40680193204_CR12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0034-5687(72)90050-3","volume":"16","author":"M Glogowska","year":"1972","unstructured":"Glogowska M, Richardson PS, Widdicombe JG, Winning AJ (1972) The role of the vagus nerves, peripheral chemoreceptors and other afferent pathways in the genesis of augmented breaths in cats and rabbits. Respir Physiol 16: 179\u2013196","journal-title":"Respir Physiol"},{"key":"40680193204_CR13","volume-title":"Statistical theory with engineering applications","author":"A Hald","year":"1960","unstructured":"Hald A (1960) Statistical theory with engineering applications. John Wiley & Sons Inc, New York"},{"key":"40680193204_CR14","volume-title":"Substituent constants for, correlation analysis in chemistry and biology","author":"C Hansch","year":"1979","unstructured":"Hansch C, Leo A (1979) Substituent constants for, correlation analysis in chemistry and biology. John Wiley, New York"},{"key":"40680193204_CR15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0773.1992.tb00546.x","volume":"71","author":"LF Hansen","year":"1992","unstructured":"Hansen LF, Knudsen A, Nielsen GD (1992) Sensory irritation effects of methyl ethyl ketone and its receptor activation mechanism. Pharmacol Toxicol 71: 201\u2013280","journal-title":"Pharmacol Toxicol"},{"key":"40680193204_CR16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/jo00891a006","volume":"40","author":"J Hine","year":"1975","unstructured":"Hine J, Mookerjee PK (1975) The intrinsic hydrophilic character of organic compounds. Correlations in terms of structural contributions. J Org Chem 40: 292\u2013298","journal-title":"J Org Chem"},{"key":"40680193204_CR17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1183\/09031936.93.01020176","volume":"1","author":"Y Jammes","year":"1988","unstructured":"Jammes Y (1988) Tonic sensory pathways of the respiratory system. Eur Respir J 1: 176\u2013183","journal-title":"Eur Respir J"},{"key":"40680193204_CR18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/15298668091425022","volume":"41","author":"LE Kane","year":"1980","unstructured":"Kane LE, Dombroske R, Alarie Y (1980) Evaluation of sensory irritation from some common industrial solvents. Am Ind Hyg Assoc J 41: 451\u2013455","journal-title":"Am Ind Hyg Assoc J"},{"key":"40680193204_CR19","volume-title":"Pharmacologic analysis of drug-receptor interaction","author":"TP Kenakin","year":"1987","unstructured":"Kenakin TP (1987) Pharmacologic analysis of drug-receptor interaction. Raven Press, New York"},{"key":"40680193204_CR20","first-page":"4709","volume-title":"Patty\u2019s industrial hygiene and toxicology","author":"WJ Krasavage","year":"1982","unstructured":"Krasavage WJ, O\u2019Donoghue JL, Divincenzo GD (1982) Ketones. In: Clayton GD, Clayton FE (eds) Patty\u2019s industrial hygiene and toxicology, vol. 2c, 3rd edn. John Wiley & Sons, New York, pp 4709\u20134800","edition":"3rd edn."},{"key":"40680193204_CR21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF00293686","volume":"61","author":"U Kristiansen","year":"1988","unstructured":"Kristiansen U, Nielsen GD (1988) Activation of the sensory irritant receptor by C7\u2013C11 n-alkanes. Arch Toxicol 61: 419\u2013425","journal-title":"Arch Toxicol"},{"key":"40680193204_CR22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-0773.1986.tb00135.x","volume":"59","author":"U Kristiansen","year":"1986","unstructured":"Kristiansen U, Hansen L, Nielsen GD, Holst E (1986) Sensory irritation and pulmonary irritation of cumene and n-propanol; mechanisms of receptor activation and desensitization. Acta Pharmacol Toxicol 59: 60\u201372","journal-title":"Acta Pharmacol Toxicol"},{"key":"40680193204_CR23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/08828032.1989.10390417","volume":"4","author":"U Kristiansen","year":"1989","unstructured":"Kristiansen U, Hansen LF, Nielsen GD (1989) Determination of vapors of cumene-propanol mixtures by single-beam infrared spectrophotometry. Appl Ind Hyg 4: 171\u2013174","journal-title":"Appl Ind Hyg"},{"key":"40680193204_CR24","volume-title":"Enzfitter","author":"RJ Leatherbarrow","year":"1987","unstructured":"Leatherbarrow RJ (1987) Enzfitter. Elsevier, Amsterdam"},{"key":"40680193204_CR25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0278-6915(84)90276-X","volume":"22","author":"J Muller","year":"1984","unstructured":"Muller J, Greff G (1984) Recherche de relations entre toxicite de molecules d\u2019interet industriel et proprietes physico-chemiques: test d\u2019irritation des voies aeriennes superieures applique a quatre familles chimiques. Food Chem Toxicol 22: 661\u2013664","journal-title":"Food Chem Toxicol"},{"key":"40680193204_CR26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/10408449109089879","volume":"21","author":"GD Nielsen","year":"1991","unstructured":"Nielsen GD (1991) Mechanisms of activation of the sensory irritant receptor by airborne chemicals. CRC Crit Rev Toxicol 21: 183\u2013208","journal-title":"CRC Crit Rev Toxicol"},{"key":"40680193204_CR27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0041-008X(82)90391-X","volume":"65","author":"GD Nielsen","year":"1982","unstructured":"Nielsen GD, Alarie Y (1982) Sensory irritation, pulmonary irritation, and respiratory stimulation by airborne benzene and alkylbenzenes: prediction of safe industrial exposure levels and correlation with their thermodynamic properties. Toxicol Appl Pharmacol 65: 459\u2013477","journal-title":"Toxicol Appl Pharmacol"},{"key":"40680193204_CR28","first-page":"119","volume":"12","author":"GD Nielsen","year":"1985","unstructured":"Nielsen GD, Bakbo JC (1985a) Exposure limits for irritants. Ann Am Conf Ind Hyg 12: 119\u2013135","journal-title":"Ann Am Conf Ind Hyg"},{"key":"40680193204_CR29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-0773.1985.tb00017.x","volume":"57","author":"GD Nielsen","year":"1985","unstructured":"Nielsen GD, Bakbo JC (1985b). Sensory irritating effects of allyl halides and a role for hydrogen bonding as a likely feature at the receptor site. Acta Pharmacol Toxicol 57: 106\u2013116","journal-title":"Acta Pharmacol Toxicol"},{"key":"40680193204_CR30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0009-2797(89)90037-9","volume":"71","author":"GD Nielsen","year":"1989","unstructured":"Nielsen GD, Yamagiwa M (1989) Structure-activity relationships of airway irritating aliphatic amines. Receptor activation mechanisms and predicted industrial exposure limits. Chem Biol Interact 71: 223\u2013244","journal-title":"Chem Biol Interact"},{"key":"40680193204_CR31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0773.1985.tb01271.x","volume":"56","author":"GD Nielsen","year":"1985","unstructured":"Nielsen GD, Olsen J, Bakbo JC, Holst E (1985) Propyl ether. II. Pulmonary irritation and anaesthesia. Acta Pharmacol Toxicol 56: 165\u2013175","journal-title":"Acta Pharmacol Toxicol"},{"key":"40680193204_CR32","first-page":"31","volume":"1","author":"GD Nielsen","year":"1990","unstructured":"Nielsen GD, Thomsen ES, Alarie Y (1990) Sensory irritant receptor compartment properties. Acta Pharm Nord 1: 31\u201344","journal-title":"Acta Pharm Nord"},{"key":"40680193204_CR33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-94-015-8088-5_8","volume-title":"Chemical, microbiological, health and comfort aspects of indoor air quality state of the art in SBS","author":"GD Nielsen","year":"1992","unstructured":"Nielsen GD, Hansen LF, Alarie Y (1992) Irritation of the upper airways. Mechanisms and structure-activity relationships. In: Kn\u00f6ppel H., Wolkoff P (eds) Chemical, microbiological, health and comfort aspects of indoor air quality state of the art in SBS. Kluwer Academic Publishers. Dordrecht, pp. 99\u2013114"},{"key":"40680193204_CR34","volume-title":"Toxicants and drugs. Kinetics and dynamics","author":"EJ O\u2019Flaherty","year":"1981","unstructured":"O\u2019Flaherty EJ (1981) Toxicants and drugs. Kinetics and dynamics. John Wiley & Sons, New York"},{"key":"40680193204_CR35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0009-2797(86)90007-4","volume":"57","author":"DW Roberts","year":"1986","unstructured":"Roberts DW (1986) QSAR for upper-respiratory tract irritation. Chem Biol Interact 57: 325\u2013345","journal-title":"Chem Biol Interact"},{"key":"40680193204_CR36","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/15298669391355017","volume":"54","author":"M Schaper","year":"1993","unstructured":"Schaper M (1993) Development of a database for sensory irritants and its use in establishing occupational exposure limits. Am Ind Hyg Assoc J 54: 488\u2013544","journal-title":"Am Ind Hyg Assoc J"},{"key":"40680193204_CR37","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2307\/4581834","volume":"51","author":"HH Schrenk","year":"1936","unstructured":"Schrenk HH, Yant WP, Patty FA (1936) Acute response of guinea pigs to vapors of some new commercial organic compounds. X. Hexanone. US Public Health Rep 51: 624\u2013631","journal-title":"US Public Health Rep"},{"key":"40680193204_CR38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(86)90183-6","volume":"376","author":"WL Silver","year":"1986","unstructured":"Silver WL, Mason JR, Adams MA, Smeraski CA (1986) Nasal trigeminal chemoreception: Responses to n-aliphatic alcohols. Brain Res 376: 221\u2013229","journal-title":"Brain Res"},{"key":"40680193204_CR39","first-page":"61","volume":"10","author":"HF Smyth","year":"1954","unstructured":"Smyth HF, Carpenter CP, Weil CS, Pozzani UC (1954) Range-finding toxicity data: list V. Arch Ind Hyg Occup Med 10: 61\u201368","journal-title":"Arch Ind Hyg Occup Med"},{"key":"40680193204_CR40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/00028896209343211","volume":"23","author":"HF Smyth","year":"1962","unstructured":"Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA (1962) range-finding toxicity data: List VI. Am Ind Hyg Assoc J 23: 95\u2013107","journal-title":"Am Ind Hyg Assoc J"},{"key":"40680193204_CR41","first-page":"1","volume":"176","author":"H Specht","year":"1940","unstructured":"Specht H, Miller JW, Valaer PJ, Sayers RR (1940) Acute response of guinea pigs to the inhalation of ketone vapors. National Inst. of Health Bulletin 176: 1\u201366","journal-title":"National Inst. of Health Bulletin"},{"issue":"Suppl 144","key":"40680193204_CR42","first-page":"1","volume":"68","author":"J Widdicombe","year":"1986","unstructured":"Widdicombe J (1986a) The neural reflexes in the airways. Eur J Respir Dis 68 [Suppl 144]: 1\u201333","journal-title":"Eur J Respir Dis"},{"key":"40680193204_CR43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0079-6123(08)62756-9","volume":"67","author":"J Widdicombe","year":"1986","unstructured":"Widdicombe J (1986b) Sensory innervation of the lungs and airways. Prog Brain Res 67: 49\u201364","journal-title":"Prog Brain Res"},{"key":"40680193204_CR44","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2307\/4581797","volume":"51","author":"WP Yant","year":"1936","unstructured":"Yant WP, Patty FA, Schrenk HH (1936) Acute response of guinea pigs to vapors of some new commercial organic compounds. IX. Pentanone. US Public Health Rep 51: 392\u2013399","journal-title":"US Public Health Rep"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002040050054\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:45:34Z","timestamp":1733186734000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s002040050054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["40680193204"],"URL":"https:\/\/doi.org\/10.1007\/s002040050054","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}