{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:21:18Z","timestamp":1790461278099,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[1994,4]]},"DOI":"10.1007\/s002040050059","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T07:30:30Z","timestamp":1030260630000},"page":"213-216","source":"Crossref","is-referenced-by-count":65,"title":["A review of the toxicology of salbutamol (albuterol)"],"prefix":"10.1007","volume":"68","author":[{"given":"Susan E.","family":"Libretto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"684213_CR1","doi-asserted-by":"crossref","unstructured":"Anon (1971) Salbutamol: a review. Drugs 1: 274\u2013302","DOI":"10.2165\/00003495-197101040-00002"},{"key":"684213_CR2","first-page":"71","volume":"15","author":"T Balaz","year":"1973","unstructured":"Balaz T (1973) Cardiotoxicity of sympathomimetic bronchodilator and vasodilating antihypertensive drugs in experimental animals. Excerpta Medica International Congress Series 15: 71\u201379","journal-title":"Excerpta Medica International Congress Series"},{"key":"684213_CR3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1677\/joe.0.0660093","volume":"66","author":"SM Barlow","year":"1975","unstructured":"Barlow SM, Morrison PG, Sullivan FM (1975) Effects of acute and chronic stress on plasma corticosterone levels in the pregnant and non-pregnant mouse. J Endocrinol 66: 93\u201399","journal-title":"J Endocrinol"},{"issue":"Suppl","key":"684213_CR4","first-page":"11","volume":"47","author":"RT Brittain","year":"1971","unstructured":"Brittain RT (1971) A comparison of the pharmacology of salbutamol with that of isoprenaline, orciprenaline and trimetoquinol. Postgrad Med J 47 [Suppl]: 11\u201316","journal-title":"Postgrad Med J"},{"key":"684213_CR5","first-page":"242","volume":"321","author":"OE Brodde","year":"1982","unstructured":"Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC (1982) Demonstration of \u03b21 and \u03b21-Adrenoreceptors in human heart by125I iodocyanopindolol (ICYP) binding (Abstract). Naunyn Schmiedebergs Arch Pharmacol 321 [Suppl] R61: 242","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"684213_CR6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/01.RES.53.6.752","volume":"53","author":"OE Brodde","year":"1983","unstructured":"Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC (1983) Coexistence of \u03b21 and \u03b22-adrenoreceptors in human right atrium. Direct identification by [125I]-iodocyanopindolol binding. Circ Res 53: 752\u2013758","journal-title":"Circ Res"},{"key":"684213_CR7","first-page":"497","volume":"20","author":"A Brown","year":"1978","unstructured":"Brown A, Blaiklock RG, Lehr D (1978) Comparative cardiotoxicity of three adrenergic agonists (Abstract). Pharmacologist 20: 497","journal-title":"Pharmacologist"},{"key":"684213_CR8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1476-5381.1969.tb07975.x","volume":"35","author":"VA Cullen","year":"1969","unstructured":"Cullen VA, Farmer JB, Jack D, Levy GP (1969) Salbutamol: a new selective \u03b2-adrenoreceptive receptor stimulant. Br J Pharmacol 35: 141\u2013151","journal-title":"Br J Pharmacol"},{"key":"684213_CR9","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0002-9378(72)90691-6","volume":"113","author":"M Fallahzadeh","year":"1972","unstructured":"Fallahzadeh M, Dockerty MB, Lee RA (1972) Leiomyoma of the ovary. Report of five cases and review of the literature. Am J Obstet Gynecol 113: 394\u2013398","journal-title":"Am J Obstet Gynecol"},{"key":"684213_CR10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/bmj.1.6113.649-a","volume":"1","author":"MJ Finkel","year":"1978","unstructured":"Finkel MJ (1978) Salbutamol: lack of evidence of tumour induction in man. BMJ 1: 649.","journal-title":"BMJ"},{"key":"684213_CR11","first-page":"229","volume-title":"Histopathology of preclinical toxicity studies. Interpretation and relevance in drug safety evaluation","author":"P Greaves","year":"1990","unstructured":"Greaves P (1990) Histopathology of preclinical toxicity studies. Interpretation and relevance in drug safety evaluation. Elsevier, Oxford, pp 229\u2013277"},{"key":"684213_CR12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0300-483X(83)90026-4","volume":"27","author":"D Jack","year":"1983","unstructured":"Jack D, Poynter D, Spurling NW (1983) Beta-adrenoceptor stimulants and mesovarian leiomyomas in the rat. Toxicology 27: 315\u2013320","journal-title":"Toxicology"},{"key":"684213_CR13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1258\/002367781780952933","volume":"15","author":"A Kast","year":"1981","unstructured":"Kast A, Nishikawa J (1981) The effect of fasting on oral acute toxicity of drugs in rats and mice. Lab Anim 15: 359\u2013364","journal-title":"Lab Anim"},{"key":"684213_CR14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/10915819309140618","volume":"12","author":"WA Kelly","year":"1993","unstructured":"Kelly WA, Marler RJ, Weikel JH (1993) Drug-induced mesovarial leiomyomas in the rat\u2014a review and additional data. J Am Coll Toxicol 12: 13\u201322","journal-title":"J Am Coll Toxicol"},{"key":"684213_CR15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/214597a0","volume":"214","author":"AM Lands","year":"1967","unstructured":"Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214: 597\u2013598","journal-title":"Nature"},{"key":"684213_CR16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000169631","volume":"58","author":"G Magnusson","year":"1973","unstructured":"Magnusson G, Hansson E (1973) Myocardial necrosis in the rat: a comparison between isoprenaline, orciprenaline, salbutamol and terbutaline. Cardiology 58: 174\u2013180","journal-title":"Cardiology"},{"issue":"Suppl","key":"684213_CR17","first-page":"16","volume":"47","author":"WG Nayler","year":"1971","unstructured":"Nayler WG (1971) Some observations on the pharmacological effects of salbutamol, with particular reference to the cardiovascular system. Postgrad Med J 47 [Suppl]: 16\u201321","journal-title":"Postgrad Med J"},{"key":"684213_CR18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/cvr\/6.6.725","volume":"6","author":"WG Nayler","year":"1972","unstructured":"Nayler WG, McInnes I (1972) Salbutamol and orciprenaline-induced changes in myocardial function. Cardiovas Res 6: 725\u2013733","journal-title":"Cardiovas Res"},{"key":"684213_CR19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/0300985871008005-00607","volume":"8","author":"LW Nelson","year":"1971","unstructured":"Nelson LW, Kelly WA (1971) Mesovarial leiomyomas in rats in a chronic toxicity study of soterenol hydrochloride. Vet Pathol 8: 452\u2013457","journal-title":"Vet Pathol"},{"key":"684213_CR20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0041-008X(72)90113-5","volume":"23","author":"LW Nelson","year":"1972","unstructured":"Nelson LW, Kelly WA, Werkel JH (1972) Mesovarial leiomyomas in rats in a chronic toxicity study of mesuprine hydrochloride. Toxicol Appl Pharmacol 23: 731\u2013737","journal-title":"Toxicol Appl Pharmacol"},{"key":"684213_CR21","first-page":"191","volume":"22","author":"R Nishioeda","year":"1981","unstructured":"Nishioeda R, Tamagawa M, Minami T, Hatori M, Tanaka N (1981) Acute toxicity of procaterol hydrochloride in rat offspring. Pharmacometrics 22: 191\u2013197","journal-title":"Pharmacometrics"},{"issue":"Suppl","key":"684213_CR22","first-page":"21","volume":"47","author":"D Poynter","year":"1971","unstructured":"Poynter D, Spurling NW (1971) Some cardiac effects of beta-adrenergic stimulants in animals. Postgrad Med J 47 [Suppl]: 21\u201324","journal-title":"Postgrad Med J"},{"key":"684213_CR23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/bmj.1.6104.46-a","volume":"1","author":"D Poynter","year":"1978","unstructured":"Poynter D, Harris DM, Jack D (1978) Salbutamol: lack of evidence of tumour induction in man. BMJ 1: 46\u201347","journal-title":"BMJ"},{"key":"684213_CR24","first-page":"464","volume":"11","author":"TW Rall","year":"1959","unstructured":"Rall TW, Sutherland EW (1959) Action of epinephrine and norepinephrine in broken cell preparations. Pharmacol Rev 11: 464\u2013465","journal-title":"Pharmacol Rev"},{"issue":"II","key":"684213_CR25","first-page":"A57","volume":"39","author":"I Spahr-Schopfer","year":"1992","unstructured":"Spahr-Schopfer I, Lerman J, Cutz E, Dolovich M (1992) Airway mucosal damage induced by high dose Ventolin\u00ae aerosol in rabbits (Abstract). Can J Anaesth 39 II [Suppl]: A57","journal-title":"Can J Anaesth"},{"key":"684213_CR26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0002-8703(69)90131-8","volume":"77","author":"HC Stanton","year":"1969","unstructured":"Stanton HC, Brenner G, Mayfield ED (1969) Studies on isoproterenol-induced cardiomegaly in rats. Am Heart J 77: 72\u201380","journal-title":"Am Heart J"},{"key":"684213_CR27","first-page":"399","volume":"39","author":"B Starosciak","year":"1983","unstructured":"Starosciak B, Pachecka J, Dobrzanski WT, Bicz W (1983) Investigation of mutagenic activity of some drugs produced by \u201cPolfa\u201d with the use of microbial genetics methods. Farm Pol 39: 399\u2013402","journal-title":"Farm Pol"},{"key":"684213_CR28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0024-3205(83)90796-8","volume":"33","author":"FL Stiles","year":"1983","unstructured":"Stiles FL, Taylor S, Lefkowitz RJ (1983) Human cardiac beta-adrenergic receptors: subtype heterogeneity delineated by direct radioligand binding. Life Sci 33: 467\u2013473","journal-title":"Life Sci"},{"key":"684213_CR29","first-page":"265","volume":"12","author":"EW Sutherland","year":"1960","unstructured":"Sutherland EW, Rall TW (1960) The relation of adenosine-3\u2032,5\u2032-phosphate and phosphorylase to the actions of catecholamines and other hormones. Pharmacol Rev 12: 265\u2013299","journal-title":"Pharmacol Rev"},{"key":"684213_CR30","first-page":"336","volume":"12","author":"KT Szabo","year":"1975","unstructured":"Szabo KT, Difebbo ME, Kang YJ (1975) Effects of several \u03b2-receptor agonists on fetal development in various species of laboratory animals: preliminary report (Abstract). Teratology 12: 336\u2013337","journal-title":"Teratology"},{"key":"684213_CR31","first-page":"379","volume":"47","author":"IIA Tabachnick","year":"1981","unstructured":"Tabachnick IIA (1981) A summary of the pharmacology and toxicology of albuterol (Proventil\u00ae) Ann Allergy 47: 379\u2013383","journal-title":"Ann Allergy"},{"key":"684213_CR32","first-page":"469","volume":"13","author":"K Yamada","year":"1977","unstructured":"Yamada K, Koshiura R, Mukawa A, Shimo T, Kubo S, Uesaka I (1977) The comparative toxicity test on cardiotoxic actions among C-78, clorprenaline, isoproterenol, salbutamol and terbutaline. Pharmacometrics 13: 469\u2013496","journal-title":"Pharmacometrics"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002040050059\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:17:16Z","timestamp":1558639036000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s002040050059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["684213"],"URL":"https:\/\/doi.org\/10.1007\/s002040050059","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}