{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:26:28Z","timestamp":1790425588544,"version":"4.1.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[1996,7]]},"DOI":"10.1007\/s002040050310","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T07:30:30Z","timestamp":1030260630000},"page":"527-539","source":"Crossref","is-referenced-by-count":34,"title":["Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: utilization of a PBPK model"],"prefix":"10.1007","volume":"70","author":[{"given":"Hisham A.","family":"El-Masri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Tessari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond S. H.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"60700527204_CR1","unstructured":"Agency for Toxic Substance and Disease Registry (ATSDR) (1989) Toxicology profile for trichloroethylene. ATSDR 1\u2013139"},{"key":"60700527204_CR2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0041-008X(79)90335-1","volume":"47","author":"ME Andersen","year":"1979","unstructured":"Andersen ME, Gargas ML, Jones RA, Jenkins Jr L (1979) The use of inhalation techniques to assess the kinetic constants of 1,1-dichloroethylene metabolism. Toxicol Appl Pharmacol 47: 395\u2013409","journal-title":"Toxicol Appl Pharmacol"},{"key":"60700527204_CR3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0041-008X(87)90035-4","volume":"89","author":"ME Andersen","year":"1987","unstructured":"Andersen ME, Gargas ML, Clewell III HJ, Severyn KM (1987) Quantitative evaluation of the metabolic interaction between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods. Toxicol Appl Pharmacol 89: 149\u2013157","journal-title":"Toxicol Appl Pharmacol"},{"key":"60700527204_CR4","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/0006-2952(82)90425-7","volume":"30","author":"AK Costa","year":"1982","unstructured":"Costa AK, Ivanetich KM (1982) Vinylidene chloride. Its metabolism by hepatic microsomal cytochrome P450 in vivo. Biochem Pharmacol 30: 2083\u20132092","journal-title":"Biochem Pharmacol"},{"key":"60700527204_CR5","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/0006-2952(84)90568-9","volume":"33","author":"W Dekant","year":"1984","unstructured":"Dekant W, Metzler M, Henschler D (1984) Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans. Biochem Pharmacol 33: 2021\u20132027","journal-title":"Biochem Pharmacol"},{"key":"60700527204_CR6","series-title":"UCRL-53740","volume-title":"Volatile organic compounds in groundwater west of LLNL","author":"MD Dresen","year":"1986","unstructured":"Dresen MD, Hoffman F (1986) Volatile organic compounds in groundwater west of LLNL, UCRL-53740. Lawrence Livermore National Laboratory, Livermore, Calif. (available form NTIS as DE860 14651)"},{"key":"60700527204_CR7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0041-008X(91)90167-D","volume":"109","author":"JW Fisher","year":"1991","unstructured":"Fisher JW, Gargas ML, Allen BC, Andersen ME (1991) Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite trichloroacetic acid in the rat and mouse. Toxicol Appl Pharmacol 109: 183\u2013196","journal-title":"Toxicol Appl Pharmacol"},{"key":"60700527204_CR8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0041-008X(86)90361-3","volume":"86","author":"ML Gargas","year":"1986","unstructured":"Gargas ML, Andersen ME, Clewell III HJ (1986) A physiologically based simulation approach for determining metabolic constants form gas uptake data. Toxicol Appl Pharmacol 86: 341\u2013352","journal-title":"Toxicol Appl Pharmacol"},{"key":"60700527204_CR9","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/0004-6981(75)90022-0","volume":"9","author":"EP Grimsud","year":"1975","unstructured":"Grimsud EP, Rasmussen RA (1975) Survey and analysis of hydrocarbons in the atmosphere by gas chromatography mass spectroscopy. Atmos Environ 9: 1014\u20131017","journal-title":"Atmos Environ"},{"key":"60700527204_CR10","first-page":"123","volume":"9","author":"J Hushon","year":"1978","unstructured":"Hushon J, Korneich M (1978) In advances in pharmacology and therapeutics Proc. 7th International conference in pharmacology. Toxicology 9: 123\u2013130","journal-title":"Toxicology"},{"issue":"2","key":"60700527204_CR11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0006-2952(92)90285-Q","volume":"43","author":"T Nakajima","year":"1992","unstructured":"Nakajima T, Wang R, Lovaara E, Park SS, Gelboin HV, Vainio H (1992) A comparative study on the contribution of cytochrome P450 isoenzymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem Pharmacol 43[2]: 251\u2013257","journal-title":"Biochem Pharmacol"},{"key":"60700527204_CR12","first-page":"382","volume":"37","author":"A Sato","year":"1980","unstructured":"Sato A, Nakajima T, Koyama Y (1980) Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats. Br J Ind Med 37: 382\u2013388","journal-title":"Br J Ind Med"},{"key":"60700527204_CR13","volume-title":"Environmental health criteria 50, Trichloroethylene","author":"World Health Organization (WHO)","year":"1985","unstructured":"World Health Organization (WHO) (1985) Environmental health criteria 50, Trichloroethylene. WHO, Geneva"},{"key":"60700527204_CR14","volume-title":"Environmental Health Criteria 100, Vinylidene chloride, ICPS","author":"World Health Organization (WHO)","year":"1990","unstructured":"World Health Organization (WHO) (1990) Environmental Health Criteria 100, Vinylidene chloride, ICPS. WHO, Geneva"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002040050310\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002040050310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:31:56Z","timestamp":1558639916000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s002040050310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["60700527204"],"URL":"https:\/\/doi.org\/10.1007\/s002040050310","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}