{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:09:37Z","timestamp":1790356177548,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T00:00:00Z","timestamp":1207958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmied Arch Pharmacol"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s00210-008-0281-z","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T09:04:51Z","timestamp":1207904691000},"page":"139-147","source":"Crossref","is-referenced-by-count":41,"title":["The in vivo gastrointestinal activity of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity"],"prefix":"10.1007","volume":"378","author":[{"given":"D. T.","family":"Beattie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-P.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Marquess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sandlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. P. A.","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,4,12]]},"reference":[{"key":"281_CR1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/BF01297028","volume":"36","author":"TL Abell","year":"1991","unstructured":"Abell TL, Camilleri M, DiMagno EP, Hench VS, Zinsmeister AR, Malagelada JR (1991) Long-term efficacy of oral cisapride in symptomatic upper gut dysmotility. Dig Dis Sci 36:616\u2013620","journal-title":"Dig Dis Sci"},{"key":"281_CR2","first-page":"27","volume":"19","author":"DW Adelson","year":"2004","unstructured":"Adelson DW, Million M (2004) Tracking the moveable feast: sonomicrometry and gastrointestinal motility. News Physiol Sci 19:27\u201332","journal-title":"News Physiol Sci"},{"key":"281_CR3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2165\/00003088-200241130-00002","volume":"41","author":"S Appel-Dingemanse","year":"2002","unstructured":"Appel-Dingemanse S (2002) Clinical pharmacokinetics of tegaserod, a serotonin 5-HT4 receptor partial agonist with promotile activity. Clin Pharmacokinet 41:1021\u20131042","journal-title":"Clin Pharmacokinet"},{"key":"281_CR4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.vascn.2005.08.004","volume":"53","author":"SR Armstrong","year":"2006","unstructured":"Armstrong SR, McCullough JL, Beattie DT (2006) Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat. J Pharmacol Toxicol Methods 53:198\u2013205","journal-title":"J Pharmacol Toxicol Methods"},{"key":"281_CR5","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/ajhp\/62.7.700","volume":"62","author":"DE Baker","year":"2005","unstructured":"Baker DE (2005) Rationale for using serotonergic agents to treat irritable bowel syndrome. Am J Health-Syst Pharm 62:700\u2013711","journal-title":"Am J Health-Syst Pharm"},{"key":"281_CR6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/107424840200700202","volume":"7","author":"JT Barbey","year":"2002","unstructured":"Barbey JT, Lazzara R, Zipes DP (2002) Spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride. J Cardiovasc Pharmacol Ther 7:65\u201376","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"281_CR7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1152\/jappl.1972.32.4.567","volume":"32","author":"P Bass","year":"1972","unstructured":"Bass P, Wiley J (1972) Contractile force transducer for recording muscle activity in unanesthetized animals. J Appl Physiol 32:567\u2013569","journal-title":"J Appl Physiol"},{"key":"281_CR8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00169544","volume":"343","author":"GS Baxter","year":"1991","unstructured":"Baxter GS, Craig DA, Clarke DE (1991) 5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 343:439\u2013446","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"281_CR9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/sj.bjp.0705929","volume":"143","author":"DT Beattie","year":"2004","unstructured":"Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N, Humphrey PPA (2004) The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol 143:549\u2013560","journal-title":"Br J Pharmacol"},{"key":"281_CR10","unstructured":"Beattie DT, Zamora F, Armstrong SR, Pulido-Rios T, Humphrey PPA (2007) Tegaserod, but not TD-5108, has effects in porcine and canine isolated coronary arteries. Br Pharmacol Soc December meeting P063"},{"key":"281_CR11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2982.2001.00280.x","volume":"13","author":"MR Briejer","year":"2001","unstructured":"Briejer MR, Prins NH, Schuurkes AJ (2001) Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs. Neurogastroenterol Motil 13:465\u2013472","journal-title":"Neurogastroenterol Motil"},{"key":"281_CR12","first-page":"44","volume":"10","author":"M Deruyttere","year":"1987","unstructured":"Deruyttere M, Lepoutre L, Heylen H, Samain H, Pennoit H (1987) Cisapride in the management of chronic functional dyspepsia: a multicenter, double-blind, placebo-controlled study. Clin Ther 10:44\u201351","journal-title":"Clin Ther"},{"key":"281_CR13","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1021\/jm00024a002","volume":"38","author":"LM Gaster","year":"1995","unstructured":"Gaster LM, Joiner GF, King FD, Wyman PA, Sutton JM, Bingham S, Ellis ES, Sanger GF, Wardle KA (1995) N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide hydrochloride: the first antagonist amide with oral activity. J Med Chem 38:4760\u20134763","journal-title":"J Med Chem"},{"key":"281_CR14","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1097\/01.mcg.0000156403.37240.30","volume":"39","author":"MD Gershon","year":"2005","unstructured":"Gershon MD (2005) Nerves, reflexes, and the enteric nervous system. J Clin Gastroenterol 39:S184\u2013S193","journal-title":"J Clin Gastroenterol"},{"key":"281_CR15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","volume":"132","author":"MD Gershon","year":"2007","unstructured":"Gershon MD, Tack J (2007) The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132:397\u2013414","journal-title":"Gastroenterology"},{"key":"281_CR16","unstructured":"Goldberg M, Li YP, Garofalo B, Valmonte A, Kitt M (2007a) TD-5108, a selective 5-HT4 agonist with high intrinsic activity, increases bowel movement frequency and provides significant overall relief in patients with chronic constipation. Submitted to the American College of Gastroenterology Annual Scientific Meeting and Postgraduate Course, Philadelphia, PA, October 12\u201317"},{"key":"281_CR17","unstructured":"Goldberg MR, Wong SL, Ganju J, Li YP, Ballow CH, Kitt MM (2007b) TD-5108, a selective 5-HT4 agonist with high intrinsic activity, shows immediate and sustained prokinetic activity in healthy subjects. Abstract 318363, Digestive Disease Week, Washington, DC, May 19\u201324"},{"key":"281_CR18","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1124\/jpet.103.053512","volume":"307","author":"JR Grider","year":"2003","unstructured":"Grider JR (2003) Neurotransmitters mediating the intestinal peristaltic reflex in the mouse. J Pharmacol Exp Ther 307:460\u2013467","journal-title":"J Pharmacol Exp Ther"},{"key":"281_CR19","first-page":"240","volume":"264","author":"GW Gullikson","year":"1993","unstructured":"Gullikson GW, Virina MA, Loeffler RF, Yang DC, Goldstin B, Wang SX, Moummi C, Flynn DL, Zabrowski DL (1993) SC-49518 enhances gastric emptying of solid and liquid meals and stimulates gastrointestinal motility in dogs by a 5-hydroxytryptamine4 receptor mechanism. J Pharmacol Exp Ther 264:240\u2013248","journal-title":"J Pharmacol Exp Ther"},{"key":"281_CR20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0300-9629(97)00085-6","volume":"118","author":"MB Hansen","year":"1997","unstructured":"Hansen MB, Skadhauge E (1997) Signal transduction pathways for serotonin as an intestinal secretagogue. Comp Biochem Physiol 118:283\u2013290","journal-title":"Comp Biochem Physiol"},{"key":"281_CR21","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3349\/ymj.2003.44.4.653","volume":"44","author":"SW Ji","year":"2003","unstructured":"Ji SW, Park H, Cho JS, Lim JH, Lee SI (2003) Investigation into the effects of mosapride on motility of guinea pig stomach, ileum, and colon. Yonsei Med J 44:653\u2013664","journal-title":"Yonsei Med J"},{"key":"281_CR22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-3565(24)37929-7","volume":"288","author":"JG Jin","year":"1999","unstructured":"Jin JG, Foxx-Orenstein AE, Grider JR (1999) Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. J Pharmacol Exp Ther 288:93\u201397","journal-title":"J Pharmacol Exp Ther"},{"key":"281_CR23","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1136\/gut.28.8.1033","volume":"28","author":"SA Muller-Lissner","year":"1987","unstructured":"Muller-Lissner SA (1987) Treatment of chronic constipation with cisapride and placebo. Gut 28:1033\u20131038","journal-title":"Gut"},{"key":"281_CR24","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1053\/j.gastro.2007.04.057","volume":"132","author":"PJ Pasricha","year":"2007","unstructured":"Pasricha PJ (2007) Desperately seeking serotonin\u2026 A commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders. Gastroenterol 132:2287\u20132290","journal-title":"Gastroenterol"},{"key":"281_CR25","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1476-5381.1991.tb12301.x","volume":"102","author":"JJ Reeves","year":"1991","unstructured":"Reeves JJ, Bunce KT, Humphrey PPA (1991) Investigation into the 5-hydroxytryptamine receptor mediating smooth muscle relaxation in the rat oesophagus. Br J Pharmacol 102:1067\u20131072","journal-title":"Br J Pharmacol"},{"key":"281_CR26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2982.1998.00106.x","volume":"10","author":"GJ Sanger","year":"1998","unstructured":"Sanger GJ, Banner SE, Smith MI, Wardle KA (1998) SB-207266: 5-HT4 receptor antagonism in human isolated gut and prevention of 5-HT-evoked sensitization of peristalsis and increased defaecation in animal models. Neurogastroenterol Motil 10:271\u2013279","journal-title":"Neurogastroenterol Motil"},{"key":"281_CR27","unstructured":"Smith JA, Beattie DT, Cuthbert AW, Ropenga A, Marquess D, Shaw J, Vickery R, Humphrey PP (2007) TD-5108, a selective, high intrinsic activity 5-HT4 receptor agonist\u2014in vitro profile at human recombinant 5-HT4 receptor splice variant and human isolated colon. Digestive Disease Week, Washington, DC, no. W1222"},{"key":"281_CR28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1476-5381.1994.tb16186.x","volume":"113","author":"FS Tam","year":"1994","unstructured":"Tam FS, Hillier K, Bunce KT (1994) Characterization of the 5-hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle. Br J Pharmacol 113:143\u2013150","journal-title":"Br J Pharmacol"},{"key":"281_CR29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-2999(01)01543-6","volume":"434","author":"S Tazawa","year":"2002","unstructured":"Tazawa S, Masuda N, Koizumi T, Kitazawa M, Nakane T, Miyata H (2002) KDR-5169, a new gastrointestinal prokinetic agent, enhances gastric contractile and emptying activities in dogs and rats. Eur J Pharmacol 434:169\u2013176","journal-title":"Eur J Pharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-008-0281-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-008-0281-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-008-0281-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T16:38:44Z","timestamp":1738168724000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-008-0281-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,12]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["281"],"URL":"https:\/\/doi.org\/10.1007\/s00210-008-0281-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,12]]}}}