{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:56:17Z","timestamp":1780444577711,"version":"3.54.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T00:00:00Z","timestamp":1268784000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmied Arch Pharmacol"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1007\/s00210-010-0494-9","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T08:15:41Z","timestamp":1268727341000},"page":"415-426","source":"Crossref","is-referenced-by-count":60,"title":["Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice"],"prefix":"10.1007","volume":"381","author":[{"given":"Monalisa Ribeiro","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Matos","family":"Ximenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Galberto Martins","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Kalyne A. M.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda A.","family":"de Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauce Socorro","family":"de Barros Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,17]]},"reference":[{"key":"494_CR1","unstructured":"Adams RP (2001) Identification of essential oils components by gas chromatography\/mass spectroscopy: Carol Stream: Allured Publishing Corporation, 455p"},{"issue":"3\/4","key":"494_CR2","first-page":"72","volume":"80","author":"RN Almeida","year":"1999","unstructured":"Almeida RN, Falc\u00e3o ACGM, Diniz RST, Quintans-J\u00fanior LJ, Polari RM, Barbosa-Filho JM, Agra MF, Duarte JC, Ferreira CD, Antoniolli AR, Ara\u00fajo CC (1999) Metodologia para avalia\u00e7\u00e3o de plantas com atividade no sistema nervoso central e alguns dados experimentais. Rev Bras Farm 80(3\/4):72\u201376","journal-title":"Rev Bras Farm"},{"key":"494_CR3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.phymed.2007.04.007","volume":"16","author":"MM Blanco","year":"2009","unstructured":"Blanco MM, Costa CA, Freire AO, Santos-Jr JG, Costa M (2009) Neurobehavioral effect of essential oil of Cymbopogon citratus in mice. Phytomedicine 16:265\u2013270","journal-title":"Phytomedicine"},{"key":"494_CR4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1590\/S0102-695X2007000400014","volume":"17","author":"AF Blank","year":"2007","unstructured":"Blank AF, Costa AG, Arrigoni-Blank MF, Cavalcanti SCH, Alves PB, Innecco R, Ehlert PAD, Sousa IF (2007) Influence of season, harvest time and drying on Java citronella (Cymbopogon winterianus Jowitt) volatile oil. Braz J Pharmacogn 17:557\u2013564","journal-title":"Braz J Pharmacogn"},{"key":"494_CR5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0091-3057(03)00112-6","volume":"3","author":"EA Carlini","year":"2003","unstructured":"Carlini EA (2003) Plants and the central nervous system. Pharmacol Biochem Behav 3:501\u2013512","journal-title":"Pharmacol Biochem Behav"},{"key":"494_CR6","unstructured":"Craveiro AA, Fernandes AG, Andrade CHS, Matos FJA, Alencar JW, Machado MIL (1981) \u00d3leos essenciais de plantas do Nordeste. Universidade Federal do Cear\u00e1, Fortaleza, pp 209"},{"key":"494_CR7","doi-asserted-by":"crossref","unstructured":"Crowell PL (1999) Prevention and therapy of cancer by dietary monoterpenes. J Nutr 129:775S\u2013778S","DOI":"10.1093\/jn\/129.3.775S"},{"key":"494_CR8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0924-8579(99)00067-9","volume":"12","author":"A Sarro De","year":"1999","unstructured":"De Sarro A, Naccari F, De Sarro G (1999a) Enhanced susceptibility of pentylenetetrazole kindled mice to quinolone effects. Int J Antimicrob Agents 12:239\u2013244","journal-title":"Int J Antimicrob Agents"},{"issue":"7","key":"494_CR9","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1128\/AAC.43.7.1729","volume":"43","author":"A Sarro De","year":"1999","unstructured":"De Sarro A, Cecchetti V, Fravolini V, Naccari F, Tabarrini O, De Sarro G (1999b) Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice. Antimicrob Agents Chemother 43(7):1729\u20131736","journal-title":"Antimicrob Agents Chemother"},{"key":"494_CR10","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.pnpbp.2006.06.003","volume":"30","author":"A Dhir","year":"2006","unstructured":"Dhir A, Naidu PS, Kulkarni SK (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog Neuro-Psychopharmacol Biol Psychiatry 30:1478\u20131485","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"494_CR11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3565(25)25801-3","volume":"129","author":"JM Fujimoto","year":"1960","unstructured":"Fujimoto JM, Pearce KB, Plaa GL (1960) Barbiturate metabolism as affected by certain agents acting on the liver. J Pharmacol Exp Ther 129:139\u2013143","journal-title":"J Pharmacol Exp Ther"},{"key":"494_CR12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/j.1528-1157.1992.tb06221.x","volume":"33","author":"K Gale","year":"1992","unstructured":"Gale K (1992) GABA and epilepsy: basic concepts from preclinical research. Epilepsia 33:S3\u2013S12","journal-title":"Epilepsia"},{"key":"494_CR13","first-page":"75","volume":"23","author":"CJ Game","year":"1975","unstructured":"Game CJ, Lodge D (1975) The pharmacology of the inhibition of dorsal horn neurones by impulses in myelinated cutaneous afferents in the cat. Exp Brain Res 23:75\u201384","journal-title":"Exp Brain Res"},{"key":"494_CR14","unstructured":"Gould MN (1997) Cancer chemoprevention and therapy by monoterpenes. Environ Health Perspect 105 (Suppl 4): 977\u2013979"},{"key":"494_CR15","unstructured":"Guenther E (1972) The essential oils. Robert E. Krieger Publishing Company Huntington, New York, 4:65\u201373"},{"issue":"2","key":"494_CR16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.euroneuro.2005.07.004","volume":"16","author":"YK Gupta","year":"2006","unstructured":"Gupta YK, Briyal S (2006) Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats. Eur Neuropsychopharmacol 16(2):85\u201391","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"494_CR17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000058044","volume":"65","author":"YK Gupta","year":"2002","unstructured":"Gupta YK, Chaudhary G, Srivastava AK (2002) Protective effect of resveratrol against pentylenetetrazol-induced seizures and its modulation by an adenosinergic system. Pharmacology 65(3):170\u2013174","journal-title":"Pharmacology"},{"key":"494_CR18","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0022-3565(24)29466-0","volume":"298","author":"RQ Huang","year":"2001","unstructured":"Huang RQ, Bell-Horner CL, Dibas MI, Covey DF, Drewe JA, Dillon GH (2001) Pentylenetetrazol-induced inhibition of recombinant gamma-aminobutyric acid type A (GABAA) receptors: mechanism and site of action. J Pharmacol Exp Ther 298:986\u2013995","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"494_CR19","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1476-5381.1992.tb14434.x","volume":"106","author":"JH Kehne","year":"1992","unstructured":"Kehne JH, Kane JM, Miller FP, Ketteler HJ, Braun DL, Senyah Y, Chaney SF, Abdallah A, Dudley MW, Ogden AM et al (1992) MDL 27, 531 selectively reverses strychnine-induced seizures in mice. Br J Pharmacol 106(4):910\u2013916","journal-title":"Br J Pharmacol"},{"key":"494_CR20","doi-asserted-by":"crossref","unstructured":"Khan GM, Smolders I, Lindekens H, Manil J, Ebinger G, Michotte Y (1999) Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. Eur J Pharmacol 373:153\u2013161","DOI":"10.1016\/S0014-2999(99)00209-5"},{"key":"494_CR21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/syn.10178","volume":"47","author":"T Kral","year":"2003","unstructured":"Kral T, Erdmann E, Sochivko D, Clusmann H, Schramm J, Dietrich D (2003) Down-regulation of mGluR8 in pilocarpine epileptic rats. Synapse 47:278\u2013284","journal-title":"Synapse"},{"key":"494_CR22","volume-title":"Plantas medicinais no Brasil: nativas e ex\u00f3ticas","author":"H Lorenzi","year":"2003","unstructured":"Lorenzi H, Matos FJA (2003) Plantas medicinais no Brasil: nativas e ex\u00f3ticas. Plantarum, Nova Odessa, S\u00e3o Paulo"},{"key":"494_CR23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0920-1211(02)00073-6","volume":"50","author":"W L\u00f6scher","year":"2002","unstructured":"L\u00f6scher W (2002) Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison for the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Res 50:105\u2013123","journal-title":"Epilepsy Res"},{"key":"494_CR24","unstructured":"Lucisano YM, Mantovani B (1984) Lysosomal enzyme release from polymorphonuclear leukocytes induced by immune complexes of IgM and of IgG. J Immunol 32: 2015-20"},{"key":"494_CR25","volume-title":"Plantas medicinais\u2014Guia de sele\u00e7\u00e3o e emprego de plantas medicinais do Nordeste do Brasil","author":"FJA Matos","year":"2007","unstructured":"Matos FJA (2007) Plantas medicinais\u2014Guia de sele\u00e7\u00e3o e emprego de plantas medicinais do Nordeste do Brasil, 3rd edn. Editora UFC, Fortaleza","edition":"3"},{"issue":"1","key":"494_CR26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0006-8993(97)01153-0","volume":"784","author":"S McGaraughty","year":"1998","unstructured":"McGaraughty S, Henry JL (1998) The effects of strychnine, bicuculline, and ketamine on immersion-inhibited dorsal horn convergent neurons in intact and spinalized rats. Brain Res 784(1):63\u201370","journal-title":"Brain Res"},{"key":"494_CR27","doi-asserted-by":"crossref","unstructured":"McGarvey DJ, Croteau R (1995) Terpenoid metabolism. Plant Cell 7: 1015\u20131026","DOI":"10.1105\/tpc.7.7.1015"},{"key":"494_CR28","first-page":"207","volume":"26","author":"BS Meldrum","year":"1981","unstructured":"Meldrum BS (1981) GABA agonists as antiepileptic agents. Adv Biochem Psychopharmacol 26:207\u2013217","journal-title":"Adv Biochem Psychopharmacol"},{"key":"494_CR29","first-page":"351","volume-title":"Basic and clinical pharmacology","author":"RA Nicoll","year":"2001","unstructured":"Nicoll RA (2001) Introduction to the pharmacology of CNS drugs. In: Katzung BG (ed) Basic and clinical pharmacology, 8th edn. Lange Medical Books\/McGraw-Hill, New York, pp 351\u2013363","edition":"8"},{"key":"494_CR30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/seiz.1999.0378","volume":"9","author":"WM Nsour","year":"2000","unstructured":"Nsour WM, Lau CB-S, Wong ICK (2000) Review on phytotherapy in epilepsy. Seizure 9:96\u2013107","journal-title":"Seizure"},{"key":"494_CR31","doi-asserted-by":"crossref","unstructured":"Oliveira AA, Almeida JP, Freitas RM, Nascimento VS, Aguiar LM, J\u00fanior HV, Fonseca FN, Viana GS, Sousa FC, Fonteles MM (2007) Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures. Cell Mol Neurobiol 27: 395\u2013406","DOI":"10.1007\/s10571-006-9132-y"},{"key":"494_CR32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.phymed.2007.09.018","volume":"15","author":"LJ Quintans-J\u00fanior","year":"2008","unstructured":"Quintans-J\u00fanior LJ, Souza TT, Leite BS, Lessa NMN, Bonjardim LR, Santos MRV, Alves PB, Blank AF, Antoniolli AR (2008) Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents. Phytomedicine 15:619\u2013624","journal-title":"Phytomedicine"},{"key":"494_CR33","doi-asserted-by":"crossref","first-page":"17151","DOI":"10.1073\/pnas.0806682105","volume":"105","author":"K Riazi","year":"2008","unstructured":"Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ (2008) Microglial activation and TNF\u03b1 production mediate altered CNS excitability following peripheral inflammation. PNAS 105:17151\u201317156","journal-title":"PNAS"},{"key":"494_CR34","unstructured":"Rang HP, Dale MM, Ritter JM, Moore PK (2003). Farmacologia, 5a. ed., Rio de Janeiro, Elsevier"},{"key":"494_CR35","doi-asserted-by":"crossref","unstructured":"Saint-Cricq de Gaulejac NS, Provost C, Vivas N (1999) Comparative study of polyphenol scavenging activities assessed by different methods. J Agric Food Chem 47: 425\u2013431","DOI":"10.1021\/jf980700b"},{"issue":"2","key":"494_CR36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1590\/S0102-695X2005000200004","volume":"15","author":"G Singi","year":"2005","unstructured":"Singi G, Damasceno DD, D\u2019Andr\u00e9a ED, Silva GA (2005) Acute effects of Allium sativum L. and Cymbopogon citratus (DC) Stapf hydroalcoholic extracts on arterial blood pressure of anesthetized rats. Braz J Pharmacogn 15(2):94\u201397","journal-title":"Braz J Pharmacogn"},{"issue":"1","key":"494_CR37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-2999(96)00830-8","volume":"319","author":"I Smolders","year":"1997","unstructured":"Smolders I, Van Belle K, Ebinger G, Michotte Y (1997a) Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. Eur J Pharmacol 319(1):21\u201329","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"494_CR38","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/sj.bjp.0701231","volume":"121","author":"I Smolders","year":"1997","unstructured":"Smolders I, Khan GM, Manil J, Ebinger G, Michotte Y (1997b) NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. Br J Pharmacol 121(6):1171\u20131179","journal-title":"Br J Pharmacol"},{"issue":"3","key":"494_CR39","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0022-3565(24)37159-9","volume":"283","author":"I Smolders","year":"1997","unstructured":"Smolders I, Khan GM, Lindekens H, Prikken S, Marvin CA, Manil J, Ebinger G, Michotte Y (1997c) Effectiveness of vigabatrin against focally evoked pilocarpine-induced seizures and concomitant changes in extracellular hippocampal and cerebellar glutamate, gamma-aminobutyric acid and dopamine levels, a microdialysis\u2013electrocorticography study in freely moving rats. J Pharmacol Exp Ther 283(3):1239\u20131248","journal-title":"J Pharmacol Exp Ther"},{"key":"494_CR40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1078\/094471102321621304","volume":"9","author":"TG Vale","year":"2002","unstructured":"Vale TG, Furtado EC, Santos JG Jr, Viana GSB (2002) Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown. Phytomedicine 9:709\u2013714","journal-title":"Phytomedicine"},{"key":"494_CR41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jep.2006.09.023","volume":"110","author":"SMM Vasconcelos","year":"2007","unstructured":"Vasconcelos SMM, Lima NM, Sales GTM, Cunha GMA, Aguiar LMV, Silveira ER, Rodrigues ACP, Macedo DS, Fonteles MMF, Sousa FCF, Viana GSB (2007) Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu. J Ethnopharmacol 110:271\u2013274","journal-title":"J Ethnopharmacol"},{"key":"494_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1535-7597.2005.05101.x","volume":"5","author":"A Vezzani","year":"2005","unstructured":"Vezzani A (2005) Inflammation and epilepsy. Epilepsy Curr 5:1\u20136","journal-title":"Epilepsy Curr"},{"key":"494_CR43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0378-8741(99)00168-3","volume":"70","author":"GSB Viana","year":"2000","unstructured":"Viana GSB, Vale TG, Pinho RSN, Matos FJA (2000) Antinociceptive effect of the essential oil from Cymbopogon citratus in mice. J Ethnopharmacol 70:323\u2013327","journal-title":"J Ethnopharmacol"},{"key":"494_CR44","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/S0022-3565(24)38314-4","volume":"289","author":"LA Walsh","year":"1999","unstructured":"Walsh LA, Li M, Zhao TJ, Chiu TH, Rosenberg HC (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J Pharmacol Exp Ther 289:1626\u20131633","journal-title":"J Pharmacol Exp Ther"},{"key":"494_CR45","first-page":"307","volume-title":"Medical neurosciences","author":"BF Westmoreland","year":"1994","unstructured":"Westmoreland BF, Benarroch EE, Dube JR, Regan TJ, Sandok BA (1994) Medical neurosciences. Mayo Foundation, Rochester, pp 307\u2013312"},{"issue":"Suppl 1","key":"494_CR46","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1111\/j.1528-1157.1997.tb04523.x","volume":"38","author":"HS White","year":"1997","unstructured":"White HS (1997) Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia 38(Suppl 1):S9\u2013S17","journal-title":"Epilepsia"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-010-0494-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-010-0494-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-010-0494-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:33:36Z","timestamp":1739972016000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-010-0494-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,17]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["494"],"URL":"https:\/\/doi.org\/10.1007\/s00210-010-0494-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,17]]}}}