{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T01:40:14Z","timestamp":1761961214319,"version":"build-2065373602"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmied Arch Pharmacol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s00210-010-0555-0","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T06:52:31Z","timestamp":1283237551000},"page":"399-407","source":"Crossref","is-referenced-by-count":18,"title":["Effects of the compounds MV8608 and MV8612 obtained from Mandevilla velutina in the model of hemorrhagic cystitis induced by cyclophosphamide in rats"],"prefix":"10.1007","volume":"382","author":[{"suffix":"Jr","given":"Andr\u00e9 A.","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo C.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I. A.","family":"Edelweiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago Giuliani","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o B.","family":"Calixto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda B.","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,9,1]]},"reference":[{"key":"555_CR1","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/S0022-5347(05)68870-2","volume":"161","author":"AM Assreuy","year":"1999","unstructured":"Assreuy AM, Martins GJ, Moreira ME, Brito GAC, Cavada BS, Ribeiro RA, Flores CA (1999) Prevention of cyclophosphamide-induced hemorrhagic cystitis by glucose-mannose binding plant lectins. J Urol 161:1988\u20131993","journal-title":"J Urol"},{"key":"555_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0022-5347(05)67495-2","volume":"164","author":"M Boucher","year":"2000","unstructured":"Boucher M, Meen M, Codron JP, Coudore F, Kemeny JL, Eschalier A (2000) Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain. J Urol 164:203\u2013208","journal-title":"J Urol"},{"key":"555_CR3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1476-5381.1985.tb11069.x","volume":"85","author":"JB Calixto","year":"1985","unstructured":"Calixto JB, Nicolau M, Yunes RA (1985) The selective antagonism of bradykinin action on rat isolated uterus by crude Mandevilla velutina extract. Br J Pharmacol 85:729\u2013731","journal-title":"Br J Pharmacol"},{"key":"555_CR4","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/0090-6980(91)90057-M","volume":"41","author":"JB Calixto","year":"1991","unstructured":"Calixto JB, Zanini Junior JC, Cruz AB, Yunes RA, Medeiros YS (1991) Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear edema in mice, but not rat stomach contraction. Prostaglandins 41:515\u2013526","journal-title":"Prostaglandins"},{"key":"555_CR5","first-page":"222","volume":"36","author":"JB Calixto","year":"1992","unstructured":"Calixto JB, Yunes RA, Cruz AB, Medeiros YS (1992) Effect of compounds from Mandevilla velutina on bradykinin-mediated contractile and relaxant responses of the isolated guinea pig trachea. Agents Actions 36:222\u2013229","journal-title":"Agents Actions"},{"key":"555_CR6","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.urology.2005.10.003","volume":"67","author":"YC Chow","year":"2006","unstructured":"Chow YC, Yang S, Huang CJ, Tzen CY, Huang PL, Su YH, Wang PS (2006) Epinephrine promotes hemostasis in rats with cyclophosphamide-induced hemorrhagic cystitis. Urology 67:636\u2013641","journal-title":"Urology"},{"key":"555_CR7","first-page":"565","volume":"232","author":"YC Chow","year":"2007","unstructured":"Chow YC, Yang S, Huang CJ, Tzen CY, Su YH, Wang PS (2007) Prophylactic intravesical instillation of epinephrine prevents cyclophosphamide-induced hemorrhagic cystitis in rats. Exp Biol Med (Maywood) 232:565\u2013570","journal-title":"Exp Biol Med (Maywood)"},{"key":"555_CR8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1046\/j.1464-410X.1996.01146.x","volume":"78","author":"LE Crocitto","year":"1996","unstructured":"Crocitto LE, Simpson JF, Wilson TG (1996) Bladder augmentation in the prevention of cyclophosphamide-induced haemorrhagic cystitis in the rat model. Br J Urol 78:530\u2013533","journal-title":"Br J Urol"},{"key":"555_CR9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0022-5347(17)49751-5","volume":"132","author":"A Freedman","year":"1984","unstructured":"Freedman A, Ehrlich RM, Ljung BM (1984) Prevention of cyclophosphamide cystitis with 2-mercaptoethane sodium sulfonate: a histologic study. J Urol 132:580\u2013582","journal-title":"J Urol"},{"issue":"2","key":"555_CR10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0022-5347(17)44929-9","volume":"136","author":"KJ Gray","year":"1986","unstructured":"Gray KJ, Engelmann UH, Johnson EH, Fishman IJ (1986) Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy. J Urol 136(2):497\u2013500, J Urol 136: 497\u2013500","journal-title":"J Urol"},{"key":"555_CR11","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/BF01986573","volume":"33","author":"MG Henriques","year":"1991","unstructured":"Henriques MG, Fernandes PD, Weg VB, Yunes RA, Cordeiro RS, Calixto JB (1991) Inhibition of rat paw edema and pleurisy by the extract from Mandevilla velutina. Agents Actions 33:272\u2013278","journal-title":"Agents Actions"},{"key":"555_CR12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/pbc.20617","volume":"49","author":"SL Khaw","year":"2007","unstructured":"Khaw SL, Downie PA, Waters KD, Ashley DM, Heath JA (2007) Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide. Pediatr Blood Cancer 49:341\u2013343","journal-title":"Pediatr Blood Cancer"},{"key":"555_CR13","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/S0022-5347(05)65932-0","volume":"166","author":"A Korkmaz","year":"2001","unstructured":"Korkmaz A, Oter S, Deveci S, Goksoy C, Bilgic H (2001) Prevention of further cyclophosphamide induced hemorrhagic cystitis by hyperbaric oxygen and mesna in guinea pigs. J Urol 166:1119\u20131123","journal-title":"J Urol"},{"key":"555_CR14","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1097\/01.ju.0000154344.80669.e3","volume":"173","author":"A Korkmaz","year":"2005","unstructured":"Korkmaz A, Oter S, Sadir S, Coskun O, Topal T, Ozler M, Bilgic H (2005) Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats. J Urol 173:1793\u20131796","journal-title":"J Urol"},{"key":"555_CR15","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s10565-006-0078-0","volume":"23","author":"A Korkmaz","year":"2007","unstructured":"Korkmaz A, Topal T, Oter S (2007) Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 23:303\u2013312","journal-title":"Cell Biol Toxicol"},{"key":"555_CR16","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/S0022-5347(17)36902-1","volume":"148","author":"DM Kranc","year":"1992","unstructured":"Kranc DM, Kim J, Straus F, Levine LA (1992) Prophylactic and therapeutic carboprost tromethamine bladder irrigation in rats with cyclophosphamide-induced hemorrhagic cystitis. J Urol 148:1326\u20131330","journal-title":"J Urol"},{"key":"555_CR17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/BF00240958","volume":"105","author":"M Lant\u00e9ri-Minet","year":"1995","unstructured":"Lant\u00e9ri-Minet M, Bon K, de Pommery J, Michiels JF, Men\u00e9trey D (1995) Cyclophosphamide cystitis as a model of visceral pain in rats: model elaboration and spinal structures involved as revealed by the expression of c-Fos and Krox-24 proteins. Exp Brain Res 105:220\u2013232","journal-title":"Exp Brain Res"},{"key":"555_CR18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0022-5347(17)36192-X","volume":"149","author":"LA Levine","year":"1993","unstructured":"Levine LA, Jarrard DF (1993) Treatment of cyclophosphamide-induced hemorrhagic cystitis with intravesical carboprost tromethamine. J Urol 149:719\u2013723","journal-title":"J Urol"},{"key":"555_CR19","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.juro.2006.11.072","volume":"177","author":"BE Linares-Fern\u00e1ndez","year":"2007","unstructured":"Linares-Fern\u00e1ndez BE, Alfieri AB (2007) Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK(1) receptors. J Urol 177:1531\u20131536","journal-title":"J Urol"},{"key":"555_CR20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.urology.2005.08.052","volume":"67","author":"H Masuda","year":"2006","unstructured":"Masuda H, Chancellor MB, Kihara K, Yoshimura N (2006) 15-deoxy-Delta12, 14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. Urology 67:435\u2013439","journal-title":"Urology"},{"key":"555_CR21","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1111\/j.1464-410X.2007.07111.x","volume":"100","author":"Y Matsuoka","year":"2007","unstructured":"Matsuoka Y, Masuda H, Yokoyama M, Kihara K (2007) Protective effects of heme oxygenase-1 against cyclophosphamide-induced haemorrhagic cystitis in rats. BJU Int 100:1402\u20131408","journal-title":"BJU Int"},{"key":"555_CR22","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.regpep.2006.04.011","volume":"136","author":"WM Mattos","year":"2006","unstructured":"Mattos WM, Campos MM, Fernandes ES, Richetti GP, Niero R, Yunes RA, Calixto JB (2006) Anti-edematogenic effects of velutinol A isolated from Mandevilla velutina: evidence for a selective inhibition of kinin B1 receptor-mediated responses. Regul Pept 136:98\u2013104","journal-title":"Regul Pept"},{"key":"555_CR23","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1590\/S0100-879X1999001000006","volume":"32","author":"MM Morais","year":"1999","unstructured":"Morais MM, Belarmino-Filho JN, Brito GA, Ribeiro RA (1999) Pharmacological and histopathological study of cyclophosphamide-induced hemorrhagic cystitis - comparison of the effects of dexamethasone and Mesna. Braz J Med Biol Res 32:1211\u20131215","journal-title":"Braz J Med Biol Res"},{"key":"555_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0014-2999(93)90177-J","volume":"243","author":"PC Neves","year":"1993","unstructured":"Neves PC, Neves MC, Cruz AB, Sant\u2019Ana AE, Yunes RA, Calixto JB (1993) Differential effects of Mandevilla velutina compounds on paw edema induced by phospholipase A2 and phospholipase C. Eur J Pharmacol 243:213\u2013219","journal-title":"Eur J Pharmacol"},{"key":"555_CR25","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00204-005-0647-7","volume":"79","author":"A Ozcan","year":"2005","unstructured":"Ozcan A, Korkmaz A, Oter S, Coskun O (2005) Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats. Arch Toxicol 79:461\u2013465","journal-title":"Arch Toxicol"},{"key":"555_CR26","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.4049\/jimmunol.172.3.1839","volume":"172","author":"GF Passos","year":"2004","unstructured":"Passos GF, Fernandes ES, Campos MM, Ara\u00fajo JG, Pesquero JL, Souza GE, Avellar MC, Teixeira MM, Calixto JB (2004) Kinin B1 receptor upregulation after lipopolysaccharide administration: role of proinflammatory cytokines and neutrophil influx. J Immunol 172:1839\u20131847","journal-title":"J Immunol"},{"key":"555_CR27","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1016\/S0022-5347(01)64907-3","volume":"157","author":"J Safron","year":"1997","unstructured":"Safron J, Rice D, Gordon D, Leaf C, White R (1997) Protective effects of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats. J Urol 157:1946\u20131950","journal-title":"J Urol"},{"issue":"2","key":"555_CR28","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/j.1464-410X.2008.07948.x","volume":"103","author":"M Sakura","year":"2008","unstructured":"Sakura M, Masuda H, Matsuoka Y, Yokoyama M, Kawakami S, Kihara K (2008) Rolipram, a specific type-4 phosphodiesterase inhibitor, inhibits cyclophosphamide-induced haemorrhagic cystitis in rats. BJU Int 103(2):264\u2013269","journal-title":"BJU Int"},{"key":"555_CR29","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0006-8993(02)03968-9","volume":"961","author":"AR Santos","year":"2003","unstructured":"Santos AR, Trentin AP, Ferreira J, Yunes RA, Calixto JB (2003) Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice. Brain Res 961:269\u2013276","journal-title":"Brain Res"},{"key":"555_CR30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1006\/gyno.1999.5680","volume":"76","author":"TM Wong","year":"2000","unstructured":"Wong TM, Yeo W, Chan LW, Mok TS (2000) Hemorrhagic pyelitis, ureteritis, and cystitis secondary to cyclophosphamide: case report and review of the literature. Gynecol Oncol 76:223\u2013225","journal-title":"Gynecol Oncol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-010-0555-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-010-0555-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-010-0555-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-010-0555-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T21:50:57Z","timestamp":1581976257000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-010-0555-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,1]]},"references-count":30,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["555"],"URL":"https:\/\/doi.org\/10.1007\/s00210-010-0555-0","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"type":"print","value":"0028-1298"},{"type":"electronic","value":"1432-1912"}],"subject":[],"published":{"date-parts":[[2010,9,1]]}}}