{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:25:42Z","timestamp":1790771142684,"version":"4.1.0"},"reference-count":106,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s00210-011-0704-0","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T03:33:44Z","timestamp":1319686424000},"page":"145-170","source":"Crossref","is-referenced-by-count":52,"title":["Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics"],"prefix":"10.1007","volume":"385","author":[{"given":"Heidrun","family":"Appl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Holzammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Haen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Stra\u00dfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"704_CR1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1124\/jpet.107.131987","volume":"325","author":"MR Ahmed","year":"2008","unstructured":"Ahmed MR, Gurevich VV, Dalby KN, Benovic JL, Gurevich EV (2008) Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation. J Pharmacol Exp Ther 325:276\u2013283","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR2","doi-asserted-by":"crossref","unstructured":"Anisuzzaman AS, Nishimune A, Yoshiki H, Uwada J, Muramatsu I (2011) Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex. J Pharmacol Exp Ther 339:186\u2013193","DOI":"10.1124\/jpet.111.182857"},{"issue":"26","key":"704_CR3","first-page":"28","volume":"92","author":"LA Antell","year":"1989","unstructured":"Antell LA, Murabito AS, Karlstadt RG (1989) Depression not associated with cimetidine. Pa Med 92(26):28","journal-title":"Pa Med"},{"key":"704_CR4","doi-asserted-by":"crossref","unstructured":"Asenjo Lobos C, Komossa K, Rummel-Kluge C, Hunger H, Schmid F, Schwarz S, Leucht S (2010) Clozapine versus other atypical antipsychotics for schizophrenia. Cochrane Database Syst Rev 10:CD006633","DOI":"10.1002\/14651858.CD006633.pub2"},{"key":"704_CR5","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1124\/mol.60.5.1133","volume":"60","author":"RA Bakker","year":"2001","unstructured":"Bakker RA, Schoonus BJ, Smit MJ, Timmerman H, Leurs R (2001) Histamine H1-receptor activation of nuclear factor-\u03baB: roles for G\u03b2\u03b3- and G\u03b1q\/11-subunits in constitutive and agonist-mediated signaling. Mol Pharmacol 60:1133\u20131142","journal-title":"Mol Pharmacol"},{"key":"704_CR6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1124\/jpet.106.118869","volume":"322","author":"RA Bakker","year":"2007","unstructured":"Bakker RA, Nicholas MW, Smith TT, Burstein ES, Hacksell U, Timmerman H, Leurs R, Brann MR, Weiner DM (2007) In vitro pharmacology of clinically used central nervous system-active drugs as inverse H1 receptor agonists. J Pharmacol Exp Ther 322:172\u2013179","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.60.1.1","volume":"60","author":"JA Ballesteros","year":"2001","unstructured":"Ballesteros JA, Shi L, Javitch JA (2001) Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure\u2013function analysis of rhodopsin-like receptors. Mol Pharmacol 60:1\u201319","journal-title":"Mol Pharmacol"},{"key":"704_CR8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2004-832687","volume":"37","author":"P Baumann","year":"2004","unstructured":"Baumann P, Hiemke C, Ulrich S, Eckermann G, Gaertner I, Gerlach M, Kuss HJ, Laux G, M\u00fcller-Oerlinghausen B, Rao ML, Riederer P, Zernig G (2004) The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry. Pharmacopsychiatry 37:243\u2013265","journal-title":"Pharmacopsychiatry"},{"key":"704_CR9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/00365528309181573","volume":"18","author":"U Becker","year":"1983","unstructured":"Becker U, Faurschou P, Jensen J, Beck Pedersen P, Ranl\u00f8v PJ (1983) Efficacy of trimipramine and cimetidine in the treatment of duodenal ulcer. A double-blind comparison. Scand J Gastroenterol 18:137\u2013143","journal-title":"Scand J Gastroenterol"},{"key":"704_CR10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF02190274","volume":"246","author":"M Berger","year":"1996","unstructured":"Berger M, Gastpar M (1996) Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci 246:235\u2013239","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"704_CR11","first-page":"46","volume":"58","author":"A Berstad","year":"1980","unstructured":"Berstad A, Bjerke K, Carlsen E, Aadland E (1980) Treatment of duodenal ulcer with antacids in combination with trimipramine or cimetidine. Scand J Gastroenterol Suppl 58:46\u201352","journal-title":"Scand J Gastroenterol Suppl"},{"key":"704_CR12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/070674378102600412","volume":"26","author":"RF Billings","year":"1981","unstructured":"Billings RF, Tang SW, Rakoff VM (1981) Depression associated with cimetidine. Can J Psychiatry 26:260\u2013261","journal-title":"Can J Psychiatry"},{"key":"704_CR13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0002-9343(85)90565-0","volume":"79","author":"AL Blum","year":"1985","unstructured":"Blum AL (1985) Therapeutic approach to ulcer healing. Am J Med 79:8\u201314","journal-title":"Am J Med"},{"key":"704_CR14","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0022-3565(25)12207-6","volume":"275","author":"ZC Chao","year":"1995","unstructured":"Chao ZC, Uetrecht JP (1995) Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells. J Pharmacol Exp Ther 275:1476\u20131483","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR15","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Y Cheng","year":"1973","unstructured":"Cheng Y, Prusoff WH (1973) Relationship between the inhibition constant (K i) and the concentration of inhibitor which causes 50 per cent inhibition (I 50) of an enzymatic reaction. Biochem Pharmacol 22:3099\u20133108","journal-title":"Biochem Pharmacol"},{"key":"704_CR16","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1126\/science.1150577","volume":"318","author":"V Cherezov","year":"2007","unstructured":"Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC (2007) High-resolution crystal structure of an engineered human \u03b22-adrenergic G protein-coupled receptor. Science 318:1258\u20131265","journal-title":"Science"},{"key":"704_CR17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1476-5381.2009.00227.x","volume":"157","author":"WM Connelly","year":"2009","unstructured":"Connelly WM, Shenton FC, Lethbridge N, Leurs R, Waldvogel HJ, Faull RL, Lees G, Chazot PL (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157:55\u201363","journal-title":"Br J Pharmacol"},{"key":"704_CR18","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.M110.166868","volume":"286","author":"S Copsel","year":"2011","unstructured":"Copsel S, Garcia C, Diez F, Vermeulem M, Baldi A, Bianciotti LG, Russel FGM, Shayo C, Davio C (2011) Multidrug resistance protein 4 (MRP4\/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem 286:6979\u20136988","journal-title":"J Biol Chem"},{"key":"704_CR19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0026-895X(25)10820-1","volume":"37","author":"T Costa","year":"1990","unstructured":"Costa T, Lang J, Gless C, Herz A (1990) Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions. Mol Pharmacol 37:383\u2013394-","journal-title":"Mol Pharmacol"},{"key":"704_CR20","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1176\/ajp.137.11.1451","volume":"137","author":"MK Crowder","year":"1980","unstructured":"Crowder MK, Pate JK (1980) A case report of cimetidine-induce depressive syndrome. Am J Psychiatry 137:1451","journal-title":"Am J Psychiatry"},{"key":"704_CR21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/287548a0","volume":"287","author":"M Dam Trung Tuong","year":"1980","unstructured":"Dam Trung Tuong M, Garbarg M, Schwartz JC (1980) Pharmacological specificity of brain histamine H2 receptors differs in intact cells and cell-free preparations. Nature 287:548\u2013551","journal-title":"Nature"},{"key":"704_CR22","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1124\/mol.109.058651","volume":"76","author":"K-F Deml","year":"2009","unstructured":"Deml K-F, Beermann S, Neumann D, Stra\u00dfer A, Seifert R (2009) Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Mol Pharmacol 76:1019\u20131030","journal-title":"Mol Pharmacol"},{"key":"704_CR23","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1517\/14740338.4.4.731","volume":"4","author":"J Fitzsimons","year":"2005","unstructured":"Fitzsimons J, Berk M, Lambert T, Bourin M, Dodd S (2005) A review of clozapine safety. Expert Opin Drug Saf 4:731\u2013744","journal-title":"Expert Opin Drug Saf"},{"key":"704_CR24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hup.917","volume":"23","author":"RJ Flanagan","year":"2008","unstructured":"Flanagan RJ, Dunk L (2008a) Haematological toxicity of drugs used in psychiatry. Hum Psychopharmacol Clin Exp 23:27\u201341","journal-title":"Hum Psychopharmacol Clin Exp"},{"key":"704_CR25","doi-asserted-by":"crossref","unstructured":"Flanagan RJ, Dunk L (2008b) Haematological toxicity of drugs used in psychiatry. Hum Psychopharmacol 23(Suppl 1):27\u201341","DOI":"10.1002\/hup.917"},{"key":"704_CR26","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1124\/mol.106.026716","volume":"70","author":"S Galandrin","year":"2006","unstructured":"Galandrin S, Bouvier M (2006) Distinct signalling profiles of \u03b21 and \u03b22 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 70:1575\u20131584","journal-title":"Mol Pharmacol"},{"key":"704_CR27","doi-asserted-by":"crossref","first-page":"20840","DOI":"10.1016\/S0021-9258(19)36764-X","volume":"267","author":"I Gantz","year":"1992","unstructured":"Gantz I, DelValle J, Wang L, Tashiro T, Munzert G, Guo Y, Konda Y, Yamada T (1992) Molecular basis for the interaction of histamine with the histamine H2 receptor. J Biol Chem 267:20840\u201320843","journal-title":"J Biol Chem"},{"key":"704_CR28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0026-895X(25)15161-4","volume":"22","author":"C Gespach","year":"1982","unstructured":"Gespach C, Saal F, Cost H, Abita JP (1982) Identification and characterization of surface receptors for histamine in the human promyelocytic leukemia cell line HL-60. Comparison with human peripheral neutrophils. Mol Pharmacol 22:547\u2013553","journal-title":"Mol Pharmacol"},{"key":"704_CR29","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/jm800841w","volume":"51","author":"P Ghorai","year":"2008","unstructured":"Ghorai P, Kraus A, Keller M, Goette C, Igel P, Schneider E, Schnell D, Bernhardt G, Dove S, Zabel M, Elz S, Seifert R, Buschauer A (2008) Acylguanidines as bioisosteres of guanidines: N G -acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. J Med Chem 51:7193\u20137204","journal-title":"J Med Chem"},{"key":"704_CR30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0922-4106(89)90031-X","volume":"172","author":"P Gierschik","year":"1989","unstructured":"Gierschik P, Sidiropoulos D, Steisslinger M, Jakbos KH (1989) Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors. Eur J Pharmacol 172:481\u2013492","journal-title":"Eur J Pharmacol"},{"key":"704_CR31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/269163a0","volume":"269","author":"JP Green","year":"1977","unstructured":"Green JP, Maayani S (1977) Tricyclic antidepressant drugs block histamine H2 receptor in brain. Nature 269:163\u2013165","journal-title":"Nature"},{"key":"704_CR32","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1515\/CCLM.2003.240","volume":"41","author":"U Gutteck","year":"2003","unstructured":"Gutteck U, Rentsch KM (2003) Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography\u2013electrospray ionization mass spectrometry. Clin Chem Lab Med 41:1571\u20131579","journal-title":"Clin Chem Lab Med"},{"key":"704_CR33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(24)01328-0","volume":"49","author":"SJ Hill","year":"1997","unstructured":"Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL (1997) International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacol Rev 49:253\u2013278","journal-title":"Pharmacol Rev"},{"key":"704_CR34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0002-9343(92)90076-N","volume":"92","author":"WM Hui","year":"1992","unstructured":"Hui WM, Lam SK, Lok AS, Ng MM, Lai CL (1992) Maintenance therapy for duodenal ulcer: a randomized controlled comparison of seven forms of treatment. Am J Med 92:265\u2013274","journal-title":"Am J Med"},{"key":"704_CR35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.mp.4000664","volume":"5","author":"C Ito","year":"2000","unstructured":"Ito C, Morisset S, Krebs MO, Oli\u00e9 JP, L\u00f4o H, Poirier MF, Lannfelt L, Schwartz JC, Arrang JM (2000) Histamine H2 receptor gene variants: lack of association with schizophrenia. Mol Psychiatry 5:159\u2013164","journal-title":"Mol Psychiatry"},{"key":"704_CR36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1192\/bjp.134.3.315","volume":"134","author":"J Johnson","year":"1979","unstructured":"Johnson J, Bailey S (1979) Cimetidine and psychiatric complications. Br J Psychiatry 134:315\u2013316","journal-title":"Br J Psychiatry"},{"key":"704_CR37","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1021\/ci700474a","volume":"48","author":"A Jongejan","year":"2008","unstructured":"Jongejan A, Lim HD, Smits RA, de Esch IJ, Haaksma E, Leurs R (2008) Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations. J Chem Inf Model 48:1455\u20131463","journal-title":"J Chem Inf Model"},{"key":"704_CR38","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1365-2125.1984.tb02420.x","volume":"17","author":"KA J\u00f6nsson","year":"1984","unstructured":"J\u00f6nsson KA, Eriksson SE, Kagevi I, Norlander B, Bodemar G, Walan A (1984) No detectable concentrations of oxmetidine but measurable concentrations of cimetidine in cerebrospinal fluid (CSF) during multiple dose treatment. Br J Clin Pharmacol 17:781\u2013782","journal-title":"Br J Clin Pharmacol"},{"key":"704_CR39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0140-6736(85)91932-4","volume":"1","author":"I Kagevi","year":"1985","unstructured":"Kagevi I, Wahlby L (1985) CSF concentrations of ranitidine. Lancet 1:164\u2013165","journal-title":"Lancet"},{"key":"704_CR40","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2125.1987.tb03261.x","volume":"24","author":"I Kagevi","year":"1987","unstructured":"Kagevi I, Thorhallsson E, Wahlby L (1987) CSF concentrations of famotidine. Br J Clin Pharmacol 24:849\u2013850","journal-title":"Br J Clin Pharmacol"},{"key":"704_CR41","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0140-6736(90)91237-5","volume":"335","author":"R Kaminsky","year":"1990","unstructured":"Kaminsky R, Moriarty TM, Bodine J, Wolf DE, Davidson M (1990) Effect of famotidine on deficit symptoms of schizophrenia. Lancet 335:1351\u20131352","journal-title":"Lancet"},{"key":"704_CR42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(83)90420-X","volume":"94","author":"S Kanba","year":"1983","unstructured":"Kanba S, Richelson E (1983) Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain tissue. Eur J Pharmacol 94:313\u2013318","journal-title":"Eur J Pharmacol"},{"key":"704_CR43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/272329a0","volume":"272","author":"PD Kanof","year":"1978","unstructured":"Kanof PD, Greengard P (1978) Brain histamine receptors as targets for antidepressant drugs. Nature 272:329\u2013333","journal-title":"Nature"},{"key":"704_CR44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature08506","volume":"462","author":"MJ Keiser","year":"2009","unstructured":"Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KLH, Edwards DD, Shoichet BK, Roth BL (2009) Predicting new molecular targets for known drugs. Nature 462:175\u2013182","journal-title":"Nature"},{"key":"704_CR45","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1124\/mol.60.6.1210","volume":"60","author":"MT Kelley","year":"2001","unstructured":"Kelley MT, B\u00fcrckst\u00fcmmer T, Wenzel-Seifert K, Dove S, Buschauer A, Seifert R (2001) Distinct interaction of human and guinea pig histamine H2 receptor with guanidine-type agonists. Mol Pharmacol 60:1210\u20131225","journal-title":"Mol Pharmacol"},{"key":"704_CR46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1124\/jpet.110.173948","volume":"36","author":"T Kenakin","year":"2011","unstructured":"Kenakin T (2011) Functional selectivity and biased receptor signalling. J Pharmacol Exp Ther 36:296\u2013302","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00210-008-0313-8","volume":"378","author":"P Kleemann","year":"2008","unstructured":"Kleemann P, Papa D, Vigil-Cruz S, Seifert R (2008) Functional reconstitution of the human chemokine receptor CXCR4 with Gi\/Go-proteins in Sf9 insect cells. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 378:261\u2013274","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"704_CR48","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tips.2007.06.003","volume":"28","author":"BK Kobilka","year":"2007","unstructured":"Kobilka BK, Deupi X (2007) Conformaional complexity of G-protein-coupled receptors. Trends Pharmacol Sci 28:397\u2013406","journal-title":"Trends Pharmacol Sci"},{"key":"704_CR49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","volume":"28","author":"WK Kroeze","year":"2003","unstructured":"Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL (2003) H1-histamine receptor affinity predicts short-term weight gain for typicaland atypical antipsychotic drugs. Neuropsychopharmacology 28:519\u2013526","journal-title":"Neuropsychopharmacology"},{"key":"704_CR50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/JCP.0b013e3181e6a082","volume":"30","author":"L Lahdelma","year":"2010","unstructured":"Lahdelma L, Oja S, Korhonen M, Andersson LC (2010) Clozapine is cytotoxic to primary cultures of human bone marrow mesenchymal stromal cells. J Clin Psychopharmacol 30:461\u2013463","journal-title":"J Clin Psychopharmacol"},{"key":"704_CR51","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.tips.2011.02.004","volume":"32","author":"R Leurs","year":"2011","unstructured":"Leurs R, Vischer HF, Wijtmans M, de Esch IJ (2011) En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family. Trends Pharmacol Sci 32:250\u2013257","journal-title":"Trends Pharmacol Sci"},{"key":"704_CR52","unstructured":"Lexi-comp (2010) http:\/\/www.lexi.com\/"},{"key":"704_CR53","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1124\/jpet.105.087965","volume":"314","author":"HD Lim","year":"2005","unstructured":"Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4-receptor. Identification of 4-methylhistamine as the first potent and selective H4-receptor agonist. J Pharmacol Exp Ther 314:1310\u20131321","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR54","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/jpet.108.140343","volume":"327","author":"HD Lim","year":"2008","unstructured":"Lim HD, Jongejan A, Bakker RA, Haaksma E, de Esch IJP, Leurs R (2008) Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. J Pharmacol Exp Ther 327:88\u201396","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR55","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1124\/mol.109.063040","volume":"77","author":"HD Lim","year":"2010","unstructured":"Lim HD, de Graaf C, Jiang W, Sadek P, McGovern PM, Istyastono EP, Bakker RA, de Esch IJ, Thurmond RL, Leurs R (2010) Molecular determinants of ligand binding to H4R species variants. Mol Pharmacol 77:734\u2013743","journal-title":"Mol Pharmacol"},{"key":"704_CR56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0022-3565(24)29309-5","volume":"299","author":"C Liu","year":"2001","unstructured":"Liu C, Wilson SJ, Kuei C, Lovenberg TW (2001) Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther 299:121\u2013130","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR57","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1345\/aph.1A045","volume":"36","author":"EL Marcu","year":"2002","unstructured":"Marcu EL, Clarfield AM, Kleinman Y, Bits H, Darmon D, Da\u2019as N (2002) Agranulocytosis associated with initiation of famotidine therapy. Ann Pharmacother 36:267\u2013271","journal-title":"Ann Pharmacother"},{"key":"704_CR58","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2741\/210","volume":"3","author":"AA Moya-Garcia","year":"2011","unstructured":"Moya-Garcia AA, Rodriguez CE, Morilla I, Sanchez-Jimenez F, Ranea JA (2011) The function of histamine receptor H4R in the brain revealed by interaction partners. Front Biosci 3:1058\u20131066","journal-title":"Front Biosci"},{"key":"704_CR59","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/0024-3205(88)90339-6","volume":"42","author":"C Nath","year":"1988","unstructured":"Nath C, Gulati A, Dhawan KN, Gupta GP (1988) Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice. Life Sci 42:2413\u20132417","journal-title":"Life Sci"},{"key":"704_CR60","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0006-2952(92)90375-S","volume":"44","author":"T Nonaka","year":"1992","unstructured":"Nonaka T, Mio M, Doi M, Tasaka K (1992) Histamine-induced differentiation of HL-60 cells. The role of protein kinase A. Biochem Pharmacol 44:1115\u20131121","journal-title":"Biochem Pharmacol"},{"key":"704_CR61","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/hup.1181","volume":"26","author":"PMM Nooijen","year":"2011","unstructured":"Nooijen PMM, Carvalho F, Flanagan RJ (2011) Haematological toxicity of clozapine and some other drugs used in psychiatry. Hum Psychopharmacol Clin Exp 26:112\u2013119","journal-title":"Hum Psychopharmacol Clin Exp"},{"key":"704_CR62","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1006\/bbrc.1994.2295","volume":"203","author":"K Ohta","year":"1994","unstructured":"Ohta K, Kayashi H, Mizuguchi H, Kagamiyama H, Fujimoto K, Fukui H (1994) Site-directed mutagenesis of the histamine H1 receptor: roles of aspartatic acid107, asparagine108 and threonine194. Biochem Biophys Res Commun 203:1096\u20131101","journal-title":"Biochem Biophys Res Commun"},{"key":"704_CR63","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF02246112","volume":"117","author":"OV Olesen","year":"1995","unstructured":"Olesen OV, Thomsen K, Jensen PN, Wulff CH, Rasmussen NA, Refshammer C, S\u00f8rensen J, Bysted M, Christensen J, Rosenberg R (1995) Clozapine serum levels and side effects during steady-state treatment of schizophrenic patients: a cross-sectional study. Psychopharmacology (Berl) 117:371\u2013378","journal-title":"Psychopharmacology (Berl)"},{"key":"704_CR64","first-page":"466","volume":"1","author":"PR Orange","year":"1996","unstructured":"Orange PR, Heath PR, Wright SR, Ramchand CN, Kolkeiwicz L, Pearson RC (1996) Individuals with schizophrenia have an increased incidence of the H2R649G allele for the histamine H2 receptor gene. Mol Psychiatry 1:466\u2013469","journal-title":"Mol Psychiatry"},{"key":"704_CR65","first-page":"145","volume":"19","author":"LK Oyewumi","year":"1994","unstructured":"Oyewumi LK, Vollick D, Merskey H, Plumb C (1994) Famotidine as an adjunct treatment of resistant schizophrenia. J Psychiatry Neurosci 19:145\u2013150","journal-title":"J Psychiatry Neurosci"},{"key":"704_CR66","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bcp.2006.06.006","volume":"72","author":"A Pereira","year":"2006","unstructured":"Pereira A, Dean B (2006) Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells. Biochem Pharmacol 72:783\u2013793","journal-title":"Biochem Pharmacol"},{"key":"704_CR67","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00210-006-0111-0","volume":"374","author":"HH Pertz","year":"2006","unstructured":"Pertz HH, G\u00f6rnemann T, Schurad B, Seifert R, Stra\u00dfer A (2006) Striking differences of action of lisuride stereoisomers at histamine H1 receptors. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 374:215\u2013222","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"704_CR68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00000441-198311000-00005","volume":"286","author":"JR Pierce Jr","year":"1983","unstructured":"Pierce JR Jr (1983) Cimetidine-associated depression and loss of libido in a woman. Am J Med Sci 286:31\u201334","journal-title":"Am J Med Sci"},{"key":"704_CR69","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1124\/jpet.107.120014","volume":"321","author":"H Preuss","year":"2007","unstructured":"Preuss H, Ghorai P, Kraus A, Dove S, Buschauer A, Seifert R (2007) Constitutive activity and ligand selectivity of human, guinea pig, rat, and canine histamine H2 receptors. J Pharmacol Exp Ther 321:983\u2013995","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR70","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature06325","volume":"450","author":"SG Rasmussen","year":"2007","unstructured":"Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK (2007) Crystal structure of the human \u03b22-adrenergic G protein-coupled receptor. Nature 450:383\u2013387","journal-title":"Nature"},{"key":"704_CR71","unstructured":"Richelson E (1982) Pharmacology of antidepressants in use in the United States. J Clin Psychiatry 43:4\u201313"},{"key":"704_CR72","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1001\/archinte.1984.00350150170037","volume":"144","author":"RK Ries","year":"1984","unstructured":"Ries RK, Gilbert DA, Katon W (1984) Tricyclic antidepressant therapy for peptic ulcer disease. Arch Intern Med 144:566\u2013569","journal-title":"Arch Intern Med"},{"key":"704_CR73","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1126\/science.1150609","volume":"318","author":"DM Rosenbaum","year":"2007","unstructured":"Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK (2007) GPCR engineering yields high-resolution structural insights into \u03b22-adrenergic receptor function. Science 318:1266\u20131273","journal-title":"Science"},{"key":"704_CR74","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature07330","volume":"455","author":"P Scheerer","year":"2008","unstructured":"Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature 455:497\u2013503","journal-title":"Nature"},{"key":"704_CR75","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1476-5381.1947.tb00336.x","volume":"2","author":"HO Schild","year":"1947","unstructured":"Schild HO (1947) pA, a new scale for the measurement of drug antagonism. Br J Pharmacol Chemother 2:189\u2013206","journal-title":"Br J Pharmacol Chemother"},{"key":"704_CR76","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bcp.2009.05.015","volume":"78","author":"EH Schneider","year":"2009","unstructured":"Schneider EH, Seifert R (2009) Histamine H4 receptor-RGS fusion proteins expressed in Sf9 cells: a sensitive and reliable approach for the functional characterization of histamine H4 receptor ligands. Biochem Pharmacol 78:607\u2013616","journal-title":"Biochem Pharmacol"},{"key":"704_CR77","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.pharmthera.2010.07.005","volume":"128","author":"EH Schneider","year":"2010","unstructured":"Schneider EH, Seifert R (2010a) Sf9 cells: a versatile model system to investigate the pharmacological properties of G protein-coupled recetors. Pharmacol Ther 128:387\u2013418","journal-title":"Pharmacol Ther"},{"key":"704_CR78","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/B978-0-12-381296-4.00028-2","volume":"485","author":"EH Schneider","year":"2010","unstructured":"Schneider EH, Seifert R (2010b) Coexpression systems as models for the analysis of constitutive GPCR activity. Methods Enzymol 485:527\u2013557","journal-title":"Methods Enzymol"},{"key":"704_CR79","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/B978-0-12-381296-4.00025-7","volume":"485","author":"EH Schneider","year":"2010","unstructured":"Schneider EH, Seifert R (2010c) Fusion proteins as model systems for the analysis of constitutive GPCR activity. Methods Enzymol 485:459\u2013480","journal-title":"Methods Enzymol"},{"key":"704_CR80","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1021\/bi802050d","volume":"48","author":"EH Schneider","year":"2009","unstructured":"Schneider EH, Schnell D, Papa D, Seifert R (2009) High constitutive activity and a G protein-independent high-affinity state of the human histamine H4 receptor. Biochemistry 48:1424\u20131438","journal-title":"Biochemistry"},{"key":"704_CR81","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1124\/jpet.110.165977","volume":"334","author":"EH Schneider","year":"2010","unstructured":"Schneider EH, Strasser A, Thurmond RL, Seifert R (2010) Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidizole-, and thienopyrrole-derived histamine H4 receptor ligands. J Pharmacol Exp Ther 334:513\u2013521","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR82","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neulet.2010.01.065","volume":"472","author":"D Schnell","year":"2010","unstructured":"Schnell D, Seifert R (2010) Modulation of histamine H3 receptor function by monovalent ions. Neurosci Lett 472:114\u2013118","journal-title":"Neurosci Lett"},{"key":"704_CR83","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1124\/jpet.109.162339","volume":"332","author":"D Schnell","year":"2010","unstructured":"Schnell D, Burleigh K, Trick J, Seifert R (2010a) No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi\/Go protein heterotrimers. J Pharmacol Exp Ther 332:996\u20131005","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR84","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.bcp.2010.07.027","volume":"80","author":"D Schnell","year":"2010","unstructured":"Schnell D, Strasser A, Seifert R (2010b) Comparison of the pharmacological properties of human and rat histamine H3-receptors. Biochem Pharmacol 80:1437\u20131449","journal-title":"Biochem Pharmacol"},{"key":"704_CR85","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00210-011-0612-3","volume":"383","author":"D Schnell","year":"2011","unstructured":"Schnell D, Brunskole I, Ladova K, Schneider EH, Igel P, Dove S, Buschauer A, Seifert R (2011) Expression and functional properties of canine, rat, and murine histamine H4 receptors in Sf9 insect cells. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 383:457\u2013470","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"704_CR86","first-page":"447","volume":"58","author":"M Schulz","year":"2003","unstructured":"Schulz M, Schmoldt A (2003) Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 58:447\u2013474","journal-title":"Pharmazie"},{"key":"704_CR87","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0165-6147(81)90285-6","volume":"2","author":"JC Schwartz","year":"1981","unstructured":"Schwartz JC, Garbarg M, Quach TT (1981) Histamine receptors in brain as targets for tricyclic antidepressants. Trends Pharmacol Sci 2:122\u2013125","journal-title":"Trends Pharmacol Sci"},{"key":"704_CR88","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0022-3565(24)29447-7","volume":"298","author":"R Seifert","year":"2001","unstructured":"Seifert R (2001) Monovalent anions differentially modulate coupling of the \u03b22-adrenoceptor to Gs\u03b1 splice variants. J Pharmacol Exp Ther 298:840\u2013847","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR89","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00210-002-0588-0","volume":"366","author":"R Seifert","year":"2002","unstructured":"Seifert R, Wenzel-Seifert K (2002) Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 366:381\u2013416","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"704_CR90","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0026-895X(25)08905-9","volume":"42","author":"R Seifert","year":"1992","unstructured":"Seifert R, H\u00f6er A, Schwaner I, Buschauer A (1992) Histamine increases cytosolic Ca2+ in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist\/antagonist profile and induces functional differentiation. Mol Pharmacol 42:235\u2013241","journal-title":"Mol Pharmacol"},{"key":"704_CR91","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1046\/j.1432-1327.1998.2550369.x","volume":"255","author":"R Seifert","year":"1998","unstructured":"Seifert R, Lee TW, Lam VT, Kobilka BK (1998) Reconstitution of \u03b22-adrenoceptor-GTP-binding-protein interaction in Sf9 cells\u2014high coupling efficiency in a \u03b22-adrenoceptor-Gs\u03b1 fusion protein. Eur J Biochem 255:369\u2013382","journal-title":"Eur J Biochem"},{"key":"704_CR92","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1124\/jpet.103.049619","volume":"305","author":"R Seifert","year":"2003","unstructured":"Seifert R, Wenzel-Seifert K, B\u00fcrckst\u00fcmmer T, Pertz HH, Schunack W, Dove S, Buschauer A, Elz S (2003) Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1 receptor. J Pharmacol Exp Ther 305:1104\u20131115","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR93","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/mol.111.071266","volume":"79","author":"R Seifert","year":"2011","unstructured":"Seifert R, Schneider EH, Dove S, Brunskole I, Neumann D, Strasser A, Buschauer A (2011) Pradoxical effects of the \u201cstandard\u201d histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity. Mol Pharmacol 79:631\u2013638","journal-title":"Mol Pharmacol"},{"key":"704_CR94","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/cmdc.200800074","volume":"3","author":"J Selent","year":"2008","unstructured":"Selent J, Lopez L, Sanz F, Pastor M (2008) Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new \u03b22 adrenergic receptor template. Chem Med Chem 3:1194\u20131198","journal-title":"Chem Med Chem"},{"key":"704_CR95","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature10236","volume":"475","author":"T Shimamura","year":"2011","unstructured":"Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S (2011) Structure of the human histamine H1 receptor complex with doxepine. Nature 475:65\u201370","journal-title":"Nature"},{"key":"704_CR96","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1124\/jpet.107.129601","volume":"324","author":"A Stra\u00dfer","year":"2008","unstructured":"Stra\u00dfer A, Striegl B, Wittmann HJ, Seifert R (2008) Pharmacological profile of histaprodifens at four recombinant histamine H1 receptor species isoforms. J Pharmacol Exp Ther 324:60\u201371","journal-title":"J Pharmacol Exp Ther"},{"key":"704_CR97","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1124\/mol.108.053009","volume":"75","author":"A Stra\u00dfer","year":"2009","unstructured":"Stra\u00dfer A, Wittmann HJ, Kunze M, Elz S, Seifert R (2009) Molecular basis for the selective interaction of syntheticagonists with the human histamine H1-receptor compared with the guinea pig H1-receptor. Mol Pharmacol 75:454\u2013465","journal-title":"Mol Pharmacol"},{"key":"704_CR98","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.2042-7158.2011.01307.x","volume":"63","author":"S Sutor","year":"2011","unstructured":"Sutor S, Heilmann J, Seifert R (2011) Impact of fusion to Gi\u03b12 and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB1R and CB2R. J Pharm Pharmacol 63:1043\u20131055","journal-title":"J Pharm Pharmacol"},{"key":"704_CR99","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0074-7742(09)85008-3","volume":"85","author":"N Takino","year":"2009","unstructured":"Takino N, Sakurai E, Kuramasu A, Okamura N, Yanai K (2009) Roles of histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward: a study of receptors gene knockout mice. Int RevNeurobiol 85:109\u2013116","journal-title":"Int RevNeurobiol"},{"key":"704_CR100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2465","volume":"7","author":"RL Thurmond","year":"2008","unstructured":"Thurmond RL, Gelfand EW, Dunford PJ (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat Rev Drug Discov 7:41\u201353","journal-title":"Nat Rev Drug Discov"},{"key":"704_CR101","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1517\/14728220903188438","volume":"18","author":"E Tiligada","year":"2009","unstructured":"Tiligada E, Zampeli E, Sander K, Stark H (2009) Histamine H3 and H4 receptors as novel drug targets. Expert Opin Investig Drugs 18:1519\u20131531","journal-title":"Expert Opin Investig Drugs"},{"key":"704_CR102","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1471-4159.1992.tb08903.x","volume":"59","author":"E Traiffort","year":"1992","unstructured":"Traiffort E, Pollard H, Moreau J, Ruat M, Schwartz JC, Martinez-Mir MI, Palacios JM (1992) Pharmacological characterization and autoradiographic localization of histamine H2 receptors in human brain identified with [125I]iodoaminopotentidine. J Neurochem 59:290\u2013299","journal-title":"J Neurochem"},{"key":"704_CR103","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/mol.58.5.954","volume":"58","author":"K Wenzel-Seifert","year":"2000","unstructured":"Wenzel-Seifert K, Seifert R (2000) Molecular analysis of \u03b22-adrenoceptor coupling to Gs-, Gi-, and Gq-proteins. Mol Pharmacol 58:954\u2013966","journal-title":"Mol Pharmacol"},{"key":"704_CR104","doi-asserted-by":"crossref","first-page":"29994","DOI":"10.1074\/jbc.274.42.29994","volume":"274","author":"K Wieland","year":"1999","unstructured":"Wieland K, ter Laak AM, Smit MJ, K\u00fchne R, Timmermann H, Leurs R (1999) Mutational analysis of the antagonist-binding site of the histamine H1 receptor. J Biol Chem 274:29994\u201330000","journal-title":"J Biol Chem"},{"key":"704_CR105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1600-0447.1985.tb08082.x","volume":"320","author":"JA Wilson","year":"1985","unstructured":"Wilson JA, Boyd EJ, Wormsley KG (1985) Effects of some polycyclic drugs on gastric secretion and on the healing of duodenal ulcers. Acta Psychiatr Scand Suppl 320:93\u201397","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"704_CR106","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00210-011-0671-5","volume":"384","author":"HJ Wittmann","year":"2011","unstructured":"Wittmann HJ, Elz S, Seifert R, Strasser A (2011) N \u03b1-methylated phenylhistamines exhibit affinity to the hH4R\u2014a pharmacological and molecular modelling study. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 384:287\u2013299","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-011-0704-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-011-0704-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-011-0704-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T05:37:35Z","timestamp":1741844255000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-011-0704-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,28]]},"references-count":106,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["704"],"URL":"https:\/\/doi.org\/10.1007\/s00210-011-0704-0","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,28]]}}}