{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T01:41:10Z","timestamp":1783215670614,"version":"3.54.6"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1007\/s00210-011-0711-1","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T09:39:10Z","timestamp":1322127550000},"page":"277-286","source":"Crossref","is-referenced-by-count":25,"title":["Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition"],"prefix":"10.1007","volume":"385","author":[{"given":"Neetu","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir","family":"Shrivastva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijai","family":"Lakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolee","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Palit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,24]]},"reference":[{"key":"711_CR1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-8741(02)00291-X","volume":"84","author":"A Anoop","year":"2003","unstructured":"Anoop A, Jegadeesan M (2003) Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus. J Ethnopharmacol 84:149\u2013156","journal-title":"J Ethnopharmacol"},{"key":"711_CR2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0076-6879(90)92064-K","volume":"192","author":"T Berglindh","year":"1990","unstructured":"Berglindh T (1990) Gastric glands and cells: preparation and in vitro methods. Methods Enzymol 192:93\u2013107","journal-title":"Methods Enzymol"},{"key":"711_CR3","first-page":"4634","volume":"59","author":"B Carlson","year":"1999","unstructured":"Carlson B, Lahusen T, Singh S, Loaiza-Perez A, Worland PJ, Pestell R, Albanese C, Sausville EA, Senderowicz AM (1999) Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res 59:4634\u20134641","journal-title":"Cancer Res"},{"key":"711_CR4","first-page":"1311","volume":"24","author":"CF Code","year":"1965","unstructured":"Code CF (1965) Histamine and gastric secretion: a later look. Fed Proc 24:1311\u20131321","journal-title":"Fed Proc"},{"key":"711_CR5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0003-2697(87)90108-4","volume":"163","author":"RS Crowther","year":"1987","unstructured":"Crowther RS, Wetmore RF (1987) Fluorometric assay of O-linked glycoproteins by reaction with 2-cyanoacetamide. Anal Biochem 163:170\u2013174","journal-title":"Anal Biochem"},{"key":"711_CR6","first-page":"145","volume":"67","author":"HT Debas","year":"1994","unstructured":"Debas HT, Carvajal SH (1994) Vagal regulation of acid secretion and gastrin release. Yale J Biol Med 67:145\u2013151","journal-title":"Yale J Biol Med"},{"key":"711_CR7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1476-5381.1974.tb09649.x","volume":"51","author":"PK Debnath","year":"1974","unstructured":"Debnath PK, Gode KD, Das DG, Sanyal AK (1974) Effects of propranolol on gastric secretion in albino rats. Br J Pharmacol 51:213\u2013216","journal-title":"Br J Pharmacol"},{"key":"711_CR8","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1023\/A:1005597220334","volume":"45","author":"N Erin","year":"2000","unstructured":"Erin N, Ercan F, Yegen BC, Arbak S, Okar I, Oktay S (2000) Role of capsaicin-sensitive nerves in gastric and hepatic injury induced by cold-restraint stress. Dig Dis Sci 45:1889\u20131899","journal-title":"Dig Dis Sci"},{"key":"711_CR9","unstructured":"Finney DJ (1952) A statistical treatment of the sigmoidal response curve. Cambridge University Press, New York, p. 318"},{"key":"711_CR10","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"G Grynkiewicz","year":"1985","unstructured":"Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440\u20133450","journal-title":"J Biol Chem"},{"key":"711_CR11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0040-4039(01)93556-7","volume":"20","author":"AD Harmon","year":"1979","unstructured":"Harmon AD, Weiss U, Silverton JV (1979) The structure of rohitukine, the main alkaloid of Amoora rohituka (Syn.) Aphanamixis polystachya (meliaceae). Tetrahedron Lett 20:721\u2013724","journal-title":"Tetrahedron Lett"},{"key":"711_CR12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0016-5085(81)90010-X","volume":"80","author":"RF Harty","year":"1981","unstructured":"Harty RF, Maico DG, McGuigan JE (1981) Role of calcium in antral gastrin release. Gastroenterology 80:491\u2013497","journal-title":"Gastroenterology"},{"key":"711_CR13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0303-7207(84)90044-3","volume":"37","author":"RF Harty","year":"1984","unstructured":"Harty RF, Maico DG, Brown CM, McGuigan JE (1984) Effects of calcium on cholinergic-stimulated gastrin release in the rat. Mol Cell Endocrinol 37:133\u2013138","journal-title":"Mol Cell Endocrinol"},{"key":"711_CR14","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/BF01918636","volume":"28","author":"G Kahlson","year":"1972","unstructured":"Kahlson G, Rosengren E (1972) Histamine: entering physiology. Experientia 28:993\u20131002","journal-title":"Experientia"},{"key":"711_CR15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1254\/jjp.29.670","volume":"29","author":"Y Kasuya","year":"1979","unstructured":"Kasuya Y, Urushidani T, Okabe S (1979) Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat. Jpn J Pharmacol 29:670\u2013673","journal-title":"Jpn J Pharmacol"},{"key":"711_CR16","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0016-5085(79)90281-6","volume":"77","author":"H Kitagawa","year":"1979","unstructured":"Kitagawa H, Fujiwara M, Osumi Y (1979) Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology 77:298\u2013302","journal-title":"Gastroenterology"},{"key":"711_CR17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-2999(95)00120-A","volume":"278","author":"SJ Konturek","year":"1995","unstructured":"Konturek SJ, Brzozowski T, Bielanski W, Schally AV (1995) Role of endogenous gastrin in gastroprotection. Eur J Pharmacol 278:203\u2013212","journal-title":"Eur J Pharmacol"},{"key":"711_CR18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.phymed.2005.10.002","volume":"14","author":"V Lakshmi","year":"2007","unstructured":"Lakshmi V, Pandey K, Kapil A, Singh N, Samant M, Dube A (2007) In vitro and in vivo leishmanicidal activity of Dysoxylum binectariferum and its fractions against Leishmania donovani. Phytomedicine 14:36\u201342","journal-title":"Phytomedicine"},{"key":"711_CR19","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/0016-5085(83)90442-0","volume":"85","author":"H Larsson","year":"1983","unstructured":"Larsson H, Carlsson E, Junggren U, Olbe L, Sjostrand SE, Skanberg I, Sundell G (1983) Inhibition of gastric acid secretion by omeprazole in the dog and rat. Gastroenterology 85:900\u2013907","journal-title":"Gastroenterology"},{"key":"711_CR20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0014-2999(96)00222-1","volume":"306","author":"O Letari","year":"1996","unstructured":"Letari O, Mennuni L, Revel L, Colombo S, Makovec F (1996) Cytosolic Ca2+ evaluation in rabbit parietal cells: a novel method to screen gastrin receptor antagonists. Eur J Pharmacol 306:325\u2013333","journal-title":"Eur J Pharmacol"},{"key":"711_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0090-6980(74)80072-9","volume":"7","author":"W Lippmann","year":"1974","unstructured":"Lippmann W (1974) Inhibition of indomethacin-induced gastric ulceration in the rat by perorally-administered synthetic and natural prostaglandin analogues. Prostaglandins 7:1\u201310","journal-title":"Prostaglandins"},{"key":"711_CR22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/expphysiol.1938.sp000768","volume":"28","author":"FC MacIntosh","year":"1938","unstructured":"MacIntosh FC (1938) Histamine as a normal stimulant of gastric secretion. Q J Exp Physiol 28:87\u201389","journal-title":"Q J Exp Physiol"},{"key":"711_CR23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0003-2697(68)90228-5","volume":"23","author":"CR McEwen","year":"1968","unstructured":"McEwen CR, Stallard RW, Juhos ET (1968) Separation of biological particles by centrifugal elutriation. Anal Biochem 23:369\u2013377","journal-title":"Anal Biochem"},{"key":"711_CR24","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0040-4020(01)90352-7","volume":"44","author":"RG Naik","year":"1988","unstructured":"Naik RG, Ramachandra G, Kattige SL, Bhat Z, Alreja B, De Souza NJ, Rupp RH (1988) An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from Dysoxylum binectariferum: isolation, structure and total synthesis. Tetrahedron 44:2081\u20132086","journal-title":"Tetrahedron"},{"key":"711_CR25","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1136\/gut.26.12.1284","volume":"26","author":"D Poynter","year":"1985","unstructured":"Poynter D, Pick CR, Harcourt RA, Selway SA, Ainge G, Harman IW, Spurling NW, Fluck PA, Cook JL (1985) Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat. Gut 26:1284\u20131295","journal-title":"Gut"},{"key":"711_CR26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0076-6879(90)92068-O","volume":"192","author":"WW Reenstra","year":"1990","unstructured":"Reenstra WW, Forte JG (1990) Isolation of H+, K(+)-ATPase-containing membranes from the gastric oxyntic cell. Methods Enzymol 192:151\u2013165","journal-title":"Methods Enzymol"},{"key":"711_CR27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0003-2697(74)90259-0","volume":"60","author":"H Sanui","year":"1974","unstructured":"Sanui H (1974) Measurement of inorganic orthophosphate in biological materials: extraction properties of butyl acetate. Anal Biochem 60:489\u2013504","journal-title":"Anal Biochem"},{"key":"711_CR28","first-page":"43","volume":"5","author":"H Shay","year":"1945","unstructured":"Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein H, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5:43\u201361","journal-title":"Gastroenterology"},{"key":"711_CR29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1172\/JCI108947","volume":"61","author":"AH Soll","year":"1978","unstructured":"Soll AH (1978) The actions of secretagogues on oxygen uptake by isolated mammalian parietal cells. J Clin Invest 61:370\u2013380","journal-title":"J Clin Invest"},{"key":"711_CR30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1043-6618(05)80109-4","volume":"23","author":"SK Srivastava","year":"1991","unstructured":"Srivastava SK, Nath C, Gupta MB, Vrat S, Sinha JN, Dhawan KN, Gupta GP (1991) Protection against gastric ulcer by verapamil. Pharmacol Res 23:81\u201386","journal-title":"Pharmacol Res"},{"key":"711_CR31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/ptr.831","volume":"15","author":"H Suleyman","year":"2001","unstructured":"Suleyman H, Demirezer LO, Buyukokuroglu ME, Akcay MF, Gepdiremen A, Banoglu ZN, Gocer F (2001) Antiulcerogenic effect of Hippophae rhamnoides L. Phytother Res 15:625\u2013627","journal-title":"Phytother Res"},{"key":"711_CR32","first-page":"147","volume":"59","author":"H Suleyman","year":"2004","unstructured":"Suleyman H, Demirezer LO, Kuruuzum-Uz A (2004) Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats. Pharmazie 59:147\u2013149","journal-title":"Pharmazie"},{"key":"711_CR33","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/BF01300266","volume":"31","author":"K Takeuchi","year":"1986","unstructured":"Takeuchi K, Ueki S, Okabe S (1986) Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci 31:1114\u20131122","journal-title":"Dig Dis Sci"},{"key":"711_CR34","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/00001574-198611000-00011","volume":"2","author":"KG Wormsley","year":"1986","unstructured":"Wormsley KG (1986) Ulcer disease: medical treatment. Curr Opin Gastroenterol 2:855\u2013868","journal-title":"Curr Opin Gastroenterol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-011-0711-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-011-0711-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-011-0711-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T21:22:59Z","timestamp":1639776179000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-011-0711-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,24]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["711"],"URL":"https:\/\/doi.org\/10.1007\/s00210-011-0711-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,24]]}}}