{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:07:31Z","timestamp":1776078451877,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,12,22]],"date-time":"2013-12-22T00:00:00Z","timestamp":1387670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s00210-013-0949-x","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T06:56:55Z","timestamp":1387609015000},"page":"341-353","source":"Crossref","is-referenced-by-count":72,"title":["Renoprotective effects of montelukast, a cysteinyl leukotriene receptor antagonist, against methotrexate-induced kidney damage in rats"],"prefix":"10.1007","volume":"387","author":[{"given":"Ihab T.","family":"Abdel-Raheem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa F.","family":"Khedr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,12,22]]},"reference":[{"key":"949_CR1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cbf.1676","volume":"28","author":"P Abraham","year":"2010","unstructured":"Abraham P, Kolli VK, Rabi S (2010) Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats. Cell Biochem Funct 28:426\u2013433","journal-title":"Cell Biochem Funct"},{"key":"949_CR2","first-page":"391","volume":"21","author":"MK Alam","year":"2012","unstructured":"Alam MK, Sutradhar SR, Pandit H, Ahmed S, Bhattacharjee M, Miah AH et al (2012) Comparative study on methotrexate and hydroxychloroquine in the treatment of rheumatoid arthritis. Mymensingh Med J 21:391\u2013398","journal-title":"Mymensingh Med J"},{"key":"949_CR3","first-page":"1003","volume":"15","author":"I Asvadi","year":"2011","unstructured":"Asvadi I, Hajipour B, Asvadi A, Asl NA, Roshangar L, Khodadadi A (2011) Protective effect of pentoxyfilline in renal toxicity after methotrexate administration. Eur Rev Med Pharmacol Sci 15:1003\u20131009","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"949_CR4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/(SICI)1099-0844(1998120)16:4<283::AID-CBF801>3.0.CO;2-E","volume":"16","author":"RM Babiak","year":"1998","unstructured":"Babiak RM, Campello AP, Carnieri EG, Oliveira MB (1998) Methotrexate: pentose cycle and oxidative stress. Cell Biochem Funct 16:283\u2013293","journal-title":"Cell Biochem Funct"},{"key":"949_CR5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.18388\/abp.1995_4899","volume":"42","author":"D Banerjee","year":"1995","unstructured":"Banerjee D, Ercikan-Abali E, Waltham M, Schnieders B, Hochhauser D, Li WW et al (1995) Molecular mechanisms of resistance to antifolates, a review. Acta Biochim Pol 42:457\u2013464","journal-title":"Acta Biochim Pol"},{"key":"949_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00280-011-1692-y","volume":"69","author":"A Beytur","year":"2012","unstructured":"Beytur A, Ciftci O, Oguz F, Oguzturk H, Yilmaz F (2012a) Montelukast attenuates side effects of cisplatin including testicular, spermatological, and hormonal damage in male rats. Cancer Chemother Pharmacol 69:207\u2013213","journal-title":"Cancer Chemother Pharmacol"},{"key":"949_CR7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/0886022X.2011.647305","volume":"34","author":"A Beytur","year":"2012","unstructured":"Beytur A, K\u00f6se E, Sarihan ME, Sapmaz HI, Dogan Z, Cetin A et al (2012b) Beneficial effects of montelukast against cisplatin-induced acute renal damage in rats. Ren Fail 34:343\u2013349","journal-title":"Ren Fail"},{"key":"949_CR8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","author":"PP Bradley","year":"1982","unstructured":"Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206\u2013209","journal-title":"J Invest Dermatol"},{"key":"949_CR9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/(SICI)1099-0844(199712)15:4<259::AID-CBF749>3.0.CO;2-D","volume":"15","author":"NN Caetano","year":"1997","unstructured":"Caetano NN, Campello AP, Carnieri EG, Kluppel ML, Oliveira MB (1997) Effect of methotrexate (MTX) on NAD(P)+ dehydrogenases of HeLa cells: malic enzyme, 2-oxoglutarate and isocitrate dehydrogenases. Cell Biochem Funct 15:259\u2013264","journal-title":"Cell Biochem Funct"},{"key":"949_CR10","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1111\/j.2042-7158.2011.01359.x","volume":"63","author":"T \u00c7ak\u0131r","year":"2011","unstructured":"\u00c7ak\u0131r T, \u00d6zkan E, Dulundu E, Topalo\u011flu \u00dc, \u015eehirli A\u00d6, Ercan F et al (2011) Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pharm Pharmacol 63:1566\u20131571","journal-title":"J Pharm Pharmacol"},{"key":"949_CR11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/ndt\/gfl420","volume":"22","author":"A Cetinkaya","year":"2007","unstructured":"Cetinkaya A, Kurutas EB, Bulbuloglu E, Kantarceken B (2007) The effects of N-acetylcysteine on methotrexate-induced oxidative renal damage in rats. Nephrol Dial Transplant 22:284\u2013285","journal-title":"Nephrol Dial Transplant"},{"key":"949_CR12","author":"AJ Chan","year":"2013","unstructured":"Chan AJ, Rajakumar I (2013) High-dose methotrexate in adult oncology patients: a case\u2013control study assessing the risk association between drug interactions and methotrexate toxicity. J Oncol Pharm Prac. doi: 10.1177\/1078155213482602","journal-title":"J Oncol Pharm Prac"},{"key":"949_CR13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/clinchem\/45.1.7","volume":"45","author":"F Chen","year":"1999","unstructured":"Chen F, Castranova V, Shi X, Demers LM (1999) New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45:7\u201317","journal-title":"Clin Chem"},{"key":"949_CR14","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1100\/tsw.2011.122","volume":"11","author":"AK Coskun","year":"2011","unstructured":"Coskun AK, Yigiter M, Oral A, Odabasoglu F, Halici Z, Mentes O et al (2011) The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis. Scientific World Journal 11:1341\u20131356","journal-title":"Scientific World Journal"},{"key":"949_CR15","first-page":"750","volume":"112","author":"M Cuciureanu","year":"2008","unstructured":"Cuciureanu M, C\u0103runtu ID, Kuchar M, Nechifor M (2008) The influence of leukotriene receptors\u2019 antagonists on experimentally induced ulcer in rats. Rev Med Chir Soc Med Nat Iasi 112:750\u2013756","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"949_CR16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1254\/jphs.FP0070122","volume":"105","author":"GO Dengiz","year":"2007","unstructured":"Dengiz GO, Odabasoglu F, Halici Z, Cadirci E, Suleyman H (2007) Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats. J Pharmacol Sci 105:94\u2013102","journal-title":"J Pharmacol Sci"},{"key":"949_CR17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/08860220500244823","volume":"27","author":"E Devrim","year":"2005","unstructured":"Devrim E, Cetin R, Kili\u00e7o\u011flu B, Erg\u00fcder BI, Avci A, Durak I (2005) Methotrexate causes oxidative stress in rat kidney tissues. Ren Fail 27:771\u2013773","journal-title":"Ren Fail"},{"key":"949_CR18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"949_CR19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1665-2681(19)31810-1","volume":"8","author":"S El-Swefy","year":"2009","unstructured":"El-Swefy S, Hassanen SI (2009) Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats. Ann Hepatol 8:41\u201349","journal-title":"Ann Hepatol"},{"key":"949_CR20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/jcp.13.2.156","volume":"13","author":"JK Fawcett","year":"1960","unstructured":"Fawcett JK, Scott JE (1960) A rapid and precise method for the determination of urea. J Clin Pathol 13:156\u2013159","journal-title":"J Clin Pathol"},{"key":"949_CR21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1182\/blood.V95.1.256","volume":"95","author":"DJ Granville","year":"2000","unstructured":"Granville DJ, Carthy CM, Jiang H, Levy JG, McManus BM, Matroule JY et al (2000) Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfin. Blood 95:256\u2013262","journal-title":"Blood"},{"key":"949_CR22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ejphar.2012.03.018","volume":"683","author":"MM Helmy","year":"2012","unstructured":"Helmy MM, El-Gowelli HM (2012) Montelukast abrogates rhabdomyolysis-induced acute renal failure via rectifying detrimental changes in antioxidant profile and systemic cytokines and apoptotic factors production. Eur J Pharmacol 683:294\u2013300","journal-title":"Eur J Pharmacol"},{"key":"949_CR23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/pros.10089","volume":"51","author":"TC Hour","year":"2002","unstructured":"Hour TC, Chen J, Huang CY, Guan JY, Lu SH, Pu YS (2002) Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1\/CIP1) and C\/EBPbeta expressions and suppressing NF-kappaB activation. Prostate 51:211\u2013218","journal-title":"Prostate"},{"key":"949_CR24","first-page":"1072","volume":"46","author":"L Huang","year":"2011","unstructured":"Huang L, Xie JN, Liang JP, Li YH, Zhou Y (2011) Sophoridine inhibits NF-kappaB signaling pathway activation in kidney tissue of endotoxemia mice. Yao Xue Xue Bao 46:1072\u20131077","journal-title":"Yao Xue Xue Bao"},{"key":"949_CR25","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1038\/sj.onc.1204535","volume":"20","author":"S Huang","year":"2001","unstructured":"Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ (2001) Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20:4188\u20134197","journal-title":"Oncogene"},{"key":"949_CR26","first-page":"5334","volume":"60","author":"S Huang","year":"2000","unstructured":"Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ (2000) Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 60:5334\u20135339","journal-title":"Cancer Res"},{"key":"949_CR27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.5414\/CNP64315","volume":"64","author":"H Izzedine","year":"2005","unstructured":"Izzedine H, Launay-Vacher V, Karie S, Caramella C, de Person F, Deray G (2005) Is low-dose methotrexate nephrotoxic? Case report and review of the literature. Clin Nephrol 64:315\u2013319","journal-title":"Clin Nephrol"},{"key":"949_CR28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2165\/00002018-200124010-00003","volume":"24","author":"PE Kintzel","year":"2001","unstructured":"Kintzel PE (2001) Anticancer drug-induced kidney disorders. Drug Saf 24:19\u201338","journal-title":"Drug Saf"},{"key":"949_CR29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000192391","volume":"55","author":"VK Kolli","year":"2009","unstructured":"Kolli VK, Abraham P, Isaac B, Selvakumar D (2009) Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage. Chemotherapy 55:83\u201390","journal-title":"Chemotherapy"},{"key":"949_CR30","first-page":"503","volume":"16","author":"E Kose","year":"2012","unstructured":"Kose E, Beytur A, Dogan Z, Ekincioglu Z, Vardi N, Cinar K et al (2012) The effects of montelukast against amikacin-induced acute renal damage. Eur Rev Med Pharmacol Sci 16:503\u2013511","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"949_CR31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0027-5107(85)90216-7","volume":"148","author":"SL Marklund","year":"1985","unstructured":"Marklund SL (1985) Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB\/c mice. Mutat Res 148:129\u2013134","journal-title":"Mutat Res"},{"key":"949_CR32","author":"J May","year":"2013","unstructured":"May J, Carson KR, Butler S, Liu W, Bartlett NL, Wagner-Johnston ND, May J, Carson KR, Butler S, Liu W, Bartlett NL, Wagner-Johnston ND (2013) High incidence of methotrexate associated renal toxicity in patients with lymphoma: a retrospective analysis. Leuk Lymphoma. doi: 10.3109\/10428194.2013.840780","journal-title":"Leuk Lymphoma"},{"key":"949_CR33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","volume":"86","author":"M Mihara","year":"1978","unstructured":"Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271\u2013278","journal-title":"Anal Biochem"},{"key":"949_CR34","first-page":"973","volume":"61","author":"J Miyazaki","year":"2003","unstructured":"Miyazaki J, Kawai K (2003) Prevention and management of nephrotoxicity from anti-cancer agents. Nihon Rinsho 61:973\u2013977","journal-title":"Nihon Rinsho"},{"key":"949_CR35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1191\/0748233706th265oa","volume":"22","author":"F Oktem","year":"2006","unstructured":"Oktem F, Yilmaz HR, Ozguner F, Olgar S, Ayata A, Uzare E et al (2006) Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester. Toxicol Ind Health 22:241\u2013247","journal-title":"Toxicol Ind Health"},{"key":"949_CR36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3109\/0886022X.2012.761040","volume":"35","author":"A Otunctemur","year":"2013","unstructured":"Otunctemur A, Ozbek E, Cekmen M, Cakir SS, Dursun M, Polat EC et al (2013) Protective effect of montelukast which is cysteinyl-leukotriene receptor antagonist on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Ren Fail 35:403\u2013410","journal-title":"Ren Fail"},{"key":"949_CR37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4318\/tjg.2013.0711","volume":"24","author":"G Ozbak\u0131\u015f-Dengiz","year":"2013","unstructured":"Ozbak\u0131\u015f-Dengiz G, Cad\u0131rc\u0131 E, Yurdakan G (2013) Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model. Turk J Gastroenterol 24:88\u201392","journal-title":"Turk J Gastroenterol"},{"key":"949_CR38","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1592\/phco.2005.25.9.1271","volume":"25","author":"A Perez-Verdia","year":"2005","unstructured":"Perez-Verdia A, Angulo F, Hardwicke FL, Nugent KM (2005) Acute cardiac toxicity associated with high-dose intravenous methotrexate therapy: case report and review of the literature. Pharmacotherapy 25:1271\u20131276","journal-title":"Pharmacotherapy"},{"key":"949_CR39","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1046\/j.1365-2222.2003.01685.x","volume":"33","author":"M Peters-Golden","year":"2003","unstructured":"Peters-Golden M (2003) Do anti-leukotriene agents inhibit asthmatic inflammation. Clin Exp Allergy 33:721\u2013724","journal-title":"Clin Exp Allergy"},{"key":"949_CR40","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1172\/JCI200215606","volume":"110","author":"G Ramesh","year":"2002","unstructured":"Ramesh G, Reeves WB (2002) TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 110:835\u2013842","journal-title":"J Clin Invest"},{"key":"949_CR41","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22:659\u2013661","journal-title":"FASEB J"},{"key":"949_CR42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.plefa.2005.07.008","volume":"73","author":"G Sener","year":"2005","unstructured":"Sener G, Sehirli O, Cetinel S, Ercan F, Y\u00fcksel M, Gedik N et al (2005) Amelioration of sepsis-induced hepatic and ileal injury in rats by the leukotriene receptor blocker montelukast. Prostaglandins Leukot Essent Fatty Acids 73:453\u2013462","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"949_CR43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phrs.2006.02.007","volume":"54","author":"G Sener","year":"2006","unstructured":"Sener G, Sehirli O, Velio\u011flu-O\u011f\u00fcn\u00e7 A, Cetinel S, Gedik N, Caner M et al (2006a) Montelukast protects against renal ischemia\/reperfusion injury in rats. Pharmacol Res 54:65\u201371","journal-title":"Pharmacol Res"},{"key":"949_CR44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10565-006-0025-0","volume":"22","author":"G Sener","year":"2006","unstructured":"Sener G, Ek\u015fio\u011flu-Demiralp E, Cetiner M, Ercan F, Sirvanci S, Gedik N et al (2006b) L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death. Cell Biol Toxicol 22:47\u201360","journal-title":"Cell Biol Toxicol"},{"key":"949_CR45","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/00365516509077065","volume":"17","author":"C Slot","year":"1965","unstructured":"Slot C (1965) Plasma creatinine determination. A new and specific Jaffe reaction method. Scand J Clin Lab Invest 17:381\u2013387","journal-title":"Scand J Clin Lab Invest"},{"key":"949_CR46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00257626","volume":"24","author":"AN Stark","year":"1989","unstructured":"Stark AN, Jackson G, Carey PJ, Arfeen S, Proctor SJ (1989) Severe renal toxicity due to intermediate-dose methotrexate. Cancer Chemother Pharmacol 24:243\u2013245","journal-title":"Cancer Chemother Pharmacol"},{"key":"949_CR47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1472-8206.2011.00996.x","volume":"27","author":"GM Suddek","year":"2013","unstructured":"Suddek GM (2013) Montelukast ameliorates kidney function and urinary bladder sensitivity in experimentally induced renal dysfunction in rats. Fundam Clin Pharmacol 27:186\u2013191","journal-title":"Fundam Clin Pharmacol"},{"key":"949_CR48","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1100\/tsw.2010.229","volume":"10","author":"GR Tintinger","year":"2010","unstructured":"Tintinger GR, Feldman C, Theron AJ, Anderson R (2010) Montelukast: more than a cysteinyl leukotriene receptor antagonist. Scientific World Journal 10:2403\u20132413","journal-title":"Scientific World Journal"},{"key":"949_CR49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejphar.2006.11.009","volume":"557","author":"H Tu\u011ftepe","year":"2007","unstructured":"Tu\u011ftepe H, Sener G, Cetinel S, Velio\u011flu-O\u011f\u00fcn\u00e7 A, Ye\u011fen BC (2007) Oxidative renal damage in pyelonephritic rats is ameliorated by montelukast, a selective leukotriene CysLT1 receptor antagonist. Eur J Pharmacol 557:69\u201375","journal-title":"Eur J Pharmacol"},{"key":"949_CR50","doi-asserted-by":"crossref","first-page":"31092","DOI":"10.1074\/jbc.272.49.31092","volume":"272","author":"A Ueda","year":"1997","unstructured":"Ueda A, Ishigatsubo Y, Okubo T, Yoshimura T (1997) Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB\/Rel subunit specificity. J Biol Chem 272:31092\u201331099","journal-title":"J Biol Chem"},{"key":"949_CR51","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/sj.leu.2403233","volume":"18","author":"B Land Van\u2019t","year":"2004","unstructured":"Van\u2019t Land B, Blijlevens NM, Marteijn J, Timal S, Donnelly JP, de Witte TJ et al (2004) Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury. Leukemia 18:276\u2013284","journal-title":"Leukemia"},{"key":"949_CR52","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s13105-012-0219-2","volume":"69","author":"N Vardi","year":"2013","unstructured":"Vardi N, Parlakpinar H, Ates B, Cetin A, Otlu A (2013) The protective effects of Prunus armeniaca L (apricot) against methotrexate-induced oxidative damage and apoptosis in rat kidney. J Physiol Biochem 69:371\u2013381","journal-title":"J Physiol Biochem"},{"key":"949_CR53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.colsurfb.2007.05.020","volume":"60","author":"B Wang","year":"2007","unstructured":"Wang B, Peng L, Zhu L, Ren P (2007) Protective effect of total flavonoids from Spirodela polyrrhiza (L.) Schleid on human umbilical vein endothelial cell damage induced by hydrogen peroxide. Colloids Surf B Biointerfaces 60:36\u201340","journal-title":"Colloids Surf B Biointerfaces"},{"key":"949_CR54","first-page":"16","volume":"124","author":"ME Weinblatt","year":"2013","unstructured":"Weinblatt ME (2013) Methotrexate in rheumatoid arthritis: a quarter century of development. Trans Am Clin Climatol Assoc 124:16\u201325","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"949_CR55","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","volume":"338","author":"GN Welch","year":"1998","unstructured":"Welch GN, Loscalzo J (1998) Homocysteine and atherothrombosis. N Engl J Med 338:1042\u20131050","journal-title":"N Engl J Med"},{"key":"949_CR56","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1634\/theoncologist.11-6-694","volume":"11","author":"BC Widemann","year":"2006","unstructured":"Widemann BC, Adamson PC (2006) Understanding and managing methotrexate nephrotoxicity. Oncologist 11:694\u2013703","journal-title":"Oncologist"},{"key":"949_CR57","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1200\/JCO.2009.25.4540","volume":"28","author":"BC Widemann","year":"2010","unstructured":"Widemann BC, Balis FM, Kim A, Boron M, Jayaprakash N, Shalabi A et al (2010) Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome. J Clin Oncol 28:3979\u20133986","journal-title":"J Clin Oncol"},{"key":"949_CR58","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.4049\/jimmunol.132.6.3034","volume":"132","author":"JD Williams","year":"1984","unstructured":"Williams JD, Czop JK, Austen KF (1984) Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. J Immunol 132:3034\u20133040","journal-title":"J Immunol"},{"key":"949_CR59","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1139\/y06-003","volume":"84","author":"Y Wu","year":"2006","unstructured":"Wu Y, Zhou C, Tao J, Li S (2006) Montelukast prevents the decrease of interleukin-10 and inhibits NF-kappaB activation in inflammatory airway of asthmatic guinea pigs. Can J Physiol Pharmacol 84:531\u2013537","journal-title":"Can J Physiol Pharmacol"},{"key":"949_CR60","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00916413","volume":"8","author":"JM Zeller","year":"1984","unstructured":"Zeller JM, Buys CM, Gudewicz PW (1984) Effects of high-dose methotrexate on rat alveolar and inflammatory macrophage populations. Inflammation 8:231\u2013239","journal-title":"Inflammation"},{"key":"949_CR61","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.humpath.2006.01.002","volume":"37","author":"L Zheng","year":"2006","unstructured":"Zheng L, Sinniah R, Hsu SI (2006) Renal cell apoptosis and proliferation may be linked to nuclear factor-kappaB activation and expression of inducible nitric oxide synthase in patients with lupus nephritis. Hum Pathol 37:637\u2013647","journal-title":"Hum Pathol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-013-0949-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-013-0949-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-013-0949-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T07:35:27Z","timestamp":1688888127000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-013-0949-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,22]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["949"],"URL":"https:\/\/doi.org\/10.1007\/s00210-013-0949-x","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,22]]}}}