{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:02Z","timestamp":1786979762821,"version":"build-2736575974"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s00210-014-0968-2","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T02:44:28Z","timestamp":1394678668000},"page":"559-567","source":"Crossref","is-referenced-by-count":40,"title":["Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats"],"prefix":"10.1007","volume":"387","author":[{"given":"Shimaa M.","family":"Elshazly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr A. A.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"968_CR1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/hep.22708","volume":"49","author":"G Aram","year":"2009","unstructured":"Aram G, Potter JJ, Liu X, Wang L, Torbenson MS, Mezey E (2009) Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology 49:911\u2013919. doi: 10.1002\/hep.22708","journal-title":"Hepatology"},{"key":"968_CR2","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.jada.2008.08.014","volume":"108","author":"S Barnes","year":"2008","unstructured":"Barnes S (2008) Nutritional genomics, polyphenols, diets, and their impact on dietetics. J Am Diet Assoc 108:1888\u20131895. doi: 10.1016\/j.jada.2008.08.014","journal-title":"J Am Diet Assoc"},{"key":"968_CR3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1055\/s-2001-17558","volume":"21","author":"R Bataller","year":"2001","unstructured":"Bataller R, Brenner DA (2001) Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 21:437\u2013451. doi: 10.1055\/s-2001-17558","journal-title":"Semin Liver Dis"},{"key":"968_CR4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209\u2013218. doi: 10.1172\/JCI24282","journal-title":"J Clin Invest"},{"key":"968_CR5","doi-asserted-by":"crossref","first-page":"3248S","DOI":"10.1093\/jn\/133.10.3248S","volume":"133","author":"GR Beecher","year":"2003","unstructured":"Beecher GR (2003) Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 133:3248S\u20133254S","journal-title":"J Nutr"},{"key":"968_CR6","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Kelly BM, Duron O (1963) Improved method for the determination of blood gluatathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"key":"968_CR7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/hep.20051","volume":"39","author":"A Canbay","year":"2004","unstructured":"Canbay A, Friedman S, Gores GJ (2004) Apoptosis: the nexus of liver injury and fibrosis. Hepatology 39:273\u2013278. doi: 10.1002\/hep.20051","journal-title":"Hepatology"},{"key":"968_CR8","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1021\/jf904549s","volume":"58","author":"MC Chen","year":"2010","unstructured":"Chen MC, Ye YY, Ji G, Liu JW (2010) Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells. J Agric Food Chem 58:3330\u20133335. doi: 10.1021\/jf904549s","journal-title":"J Agric Food Chem"},{"key":"968_CR9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/clinchem\/23.4.754","volume":"23","author":"V Chromy","year":"1977","unstructured":"Chromy V, Fischer J (1977) Photometric determination of total protein in lipemic sera. Clin Chem 23:754\u2013756","journal-title":"Clin Chem"},{"key":"968_CR10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-5793(95)00764-Z","volume":"369","author":"V Darley-Usmar","year":"1995","unstructured":"Darley-Usmar V, Wiseman H, Halliwell B (1995) Nitric oxide and oxygen radicals: a question of balance. FEBS Lett 369:131\u2013135","journal-title":"FEBS Lett"},{"key":"968_CR11","doi-asserted-by":"crossref","first-page":"33881","DOI":"10.1074\/jbc.274.48.33881","volume":"274","author":"PJ Bleser De","year":"1999","unstructured":"De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A (1999) Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J Biol Chem 274:33881\u201333887","journal-title":"J Biol Chem"},{"key":"968_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.numecd.2009.05.015","volume":"20","author":"D Rio Del","year":"2010","unstructured":"Del Rio D, Costa LG, Lean ME, Crozier A (2010) Polyphenols and health: what compounds are involved? Nutr Metab Cardiovasc Dis 20:1\u20136. doi: 10.1016\/j.numecd.2009.05.015","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"968_CR13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3748\/wjg.v5.i5.397","volume":"5","author":"WD Du","year":"1999","unstructured":"Du WD, Zhang YE, Zhai WR, Zhou XM (1999) Dynamic changes of type I, III and IV collagen synthesis and distribution of collagen-producing cells in carbon tetrachloride-induced rat liver fibrosis. World J Gastroenterol 5:397\u2013403","journal-title":"World J Gastroenterol"},{"key":"968_CR14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/phrs.2000.0772","volume":"43","author":"AS El-Khatib","year":"2001","unstructured":"El-Khatib AS, Moustafa AM, Abdel-Aziz AA, Al-Shabanah OA, El-Kashef HA (2001) Effects of aminoguanidine and desferrioxamine on some vascular and biochemical changes associated with streptozotocin-induced hyperglycaemia in rats. Pharmacol Res 43:233\u2013240. doi: 10.1006\/phrs.2000.0772","journal-title":"Pharmacol Res"},{"key":"968_CR15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijpharm.2006.04.023","volume":"319","author":"MS El-Samaligy","year":"2006","unstructured":"El-Samaligy MS, Afifi NN, Mahmoud EA (2006) Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance. Int J Pharm 319:121\u2013129. doi: 10.1016\/j.ijpharm.2006.04.023","journal-title":"Int J Pharm"},{"key":"968_CR16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.lfs.2008.11.012","volume":"84","author":"EO Farombi","year":"2009","unstructured":"Farombi EO, Shrotriya S, Surh YJ (2009) Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1. Life Sci 84:149\u2013155. doi: 10.1016\/j.lfs.2008.11.012","journal-title":"Life Sci"},{"key":"968_CR17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0168-8278(97)80189-4","volume":"27","author":"PR Galle","year":"1997","unstructured":"Galle PR (1997) Apoptosis in liver disease. J Hepatol 27:405\u2013412","journal-title":"J Hepatol"},{"key":"968_CR18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0009-8981(03)00285-7","volume":"335","author":"J George","year":"2003","unstructured":"George J (2003) Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats. Clin Chim Acta 335:39\u201347","journal-title":"Clin Chim Acta"},{"key":"968_CR19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(00)00352-8","volume":"156","author":"J George","year":"2001","unstructured":"George J, Rao KR, Stern R, Chandrakasan G (2001) Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen. Toxicology 156:129\u2013138","journal-title":"Toxicology"},{"key":"968_CR20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(00)02010-X","volume":"482","author":"RA Gottlieb","year":"2000","unstructured":"Gottlieb RA (2000) Mitochondria: execution central. FEBS Lett 482:6\u201312","journal-title":"FEBS Lett"},{"key":"968_CR21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/toxsci\/57.2.240","volume":"57","author":"TL Horn","year":"2000","unstructured":"Horn TL, Bhattacharjee A, Schook LB, Rutherford MS (2000) Altered hepatic mRNA expression of apoptotic genes during dimethylnitrosamine exposure. Toxicol Sci 57:240\u2013249","journal-title":"Toxicol Sci"},{"key":"968_CR22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jcpa.2005.01.011","volume":"133","author":"M Ide","year":"2005","unstructured":"Ide M, Kuwamura M, Kotani T, Sawamoto O, Yamate J (2005) Effects of gadolinium chloride (GdCl(3)) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions. J Comp Pathol 133:92\u2013102. doi: 10.1016\/j.jcpa.2005.01.011","journal-title":"J Comp Pathol"},{"key":"968_CR23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","volume":"6","author":"G Kroemer","year":"2000","unstructured":"Kroemer G, Reed JC (2000) Mitochondrial control of cell death. Nat Med 6:513\u2013519. doi: 10.1038\/74994","journal-title":"Nat Med"},{"key":"968_CR24","first-page":"201","volume":"26","author":"TM Leung","year":"2011","unstructured":"Leung TM, Fung ML, Liong EC, Lau TY, Nanji AA, Tipoe GL (2011) Role of nitric oxide in the regulation of fibrogenic factors in experimental liver fibrosis in mice. Histol Histopathol 26:201\u2013211","journal-title":"Histol Histopathol"},{"key":"968_CR25","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1440-1746.1999.01928.x","volume":"14","author":"D Li","year":"1999","unstructured":"Li D, Friedman SL (1999) Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J Gastroenterol Hepatol 14:618\u2013633","journal-title":"J Gastroenterol Hepatol"},{"key":"968_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-12-1","volume":"12","author":"C Liu","year":"2012","unstructured":"Liu C, Wang G, Chen G, Mu Y, Zhang L, Hu X, Sun M, Liu C, Liu P (2012) Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis. BMC Complement Altern Med 12:1\u20138. doi: 10.1186\/1472-6882-12-51","journal-title":"BMC Complement Altern Med"},{"key":"968_CR27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402\u2013408. doi: 10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"968_CR28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev.pharmtox.45.120403.095906","volume":"45","author":"S Lotersztajn","year":"2005","unstructured":"Lotersztajn S, Julien B, Teixeira-Clerc F, Grenard P, Mallat A (2005) Hepatic fibrosis: molecular mechanisms and drug targets. Annu Rev Pharmacol Toxicol 45:605\u2013628. doi: 10.1146\/annurev.pharmtox.45.120403.095906","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"968_CR29","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1478-3231.2006.01364.x","volume":"26","author":"G Novitskiy","year":"2006","unstructured":"Novitskiy G, Potter JJ, Wang L, Mezey E (2006) Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis. Liver Int 26:1248\u20131257. doi: 10.1111\/j.1478-3231.2006.01364.x","journal-title":"Liver Int"},{"key":"968_CR30","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/hep.1840160426","volume":"16","author":"M Parola","year":"1992","unstructured":"Parola M, Leonarduzzi G, Biasi F, Albano E, Biocca ME, Poli G, Dianzani MU (1992) Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis. Hepatology 16:1014\u20131021","journal-title":"Hepatology"},{"key":"968_CR31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0098-2997(00)00004-2","volume":"21","author":"G Poli","year":"2000","unstructured":"Poli G (2000) Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med 21:49\u201398","journal-title":"Mol Aspects Med"},{"key":"968_CR32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0168-8278(96)80238-8","volume":"25","author":"HL Reeves","year":"1996","unstructured":"Reeves HL, Burt AD, Wood S, Day CP (1996) Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis. J Hepatol 25:677\u2013683","journal-title":"J Hepatol"},{"key":"968_CR33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel S (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56\u201363","journal-title":"Am J Clin Pathol"},{"key":"968_CR34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.etp.2009.03.010","volume":"62","author":"J Renugadevi","year":"2010","unstructured":"Renugadevi J, Prabu SM (2010) Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol 62:171\u2013181. doi: 10.1016\/j.etp.2009.03.010","journal-title":"Exp Toxicol Pathol"},{"key":"968_CR35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.nutr.22.111401.144957","volume":"22","author":"JA Ross","year":"2002","unstructured":"Ross JA, Kasum CM (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22:19\u201334. doi: 10.1146\/annurev.nutr.22.111401.144957","journal-title":"Annu Rev Nutr"},{"key":"968_CR36","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0168-8278(02)00266-0","volume":"37","author":"P Sanz-Cameno","year":"2002","unstructured":"Sanz-Cameno P, Medina J, Garcia-Buey L, Garcia-Sanchez A, Borque MJ, Martin-Vilchez S, Gamallo C, Jones EA, Moreno-Otero R (2002) Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis. J Hepatol 37:723\u2013729","journal-title":"J Hepatol"},{"key":"968_CR37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","volume":"90","author":"K Satoh","year":"1978","unstructured":"Satoh K (1978) Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta 90:37\u201343","journal-title":"Clin Chim Acta"},{"key":"968_CR38","doi-asserted-by":"crossref","first-page":"102S","DOI":"10.1097\/01.alc.0000189275.97419.58","volume":"29","author":"SV Siegmund","year":"2005","unstructured":"Siegmund SV, Brenner DA (2005) Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res 29:102S\u2013109S","journal-title":"Alcohol Clin Exp Res"},{"key":"968_CR39","first-page":"684","volume":"27","author":"NP Skakun","year":"1982","unstructured":"Skakun NP, Vysotskii I (1982) Effect of tetracycline antibiotics on lipid peroxidation. Antibiotiki 27:684\u2013687","journal-title":"Antibiotiki"},{"key":"968_CR40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1258\/0004563011900696","volume":"38","author":"O Sonntag","year":"2001","unstructured":"Sonntag O, Scholer A (2001) Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies. Ann Clin Biochem 38:376\u2013385","journal-title":"Ann Clin Biochem"},{"key":"968_CR41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3181\/00379727-115-29134","volume":"115","author":"DA Sorg","year":"1964","unstructured":"Sorg DA, Buckner B (1964) A simple method of obtaining venous blood from small laboratory animals. Proc Soc Exp Biol Med 115:1131\u20131132","journal-title":"Proc Soc Exp Biol Med"},{"key":"968_CR42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0742-8413(97)00198-9","volume":"119","author":"CP Soto","year":"1998","unstructured":"Soto CP, Perez BL, Favari LP, Reyes JL (1998) Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 119:125\u2013129","journal-title":"Comp Biochem Physiol C Pharmacol Toxicol Endocrinol"},{"key":"968_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0676.2001.210101.x","volume":"21","author":"G Svegliati-Baroni","year":"2001","unstructured":"Svegliati-Baroni G, Saccomanno S, van Goor H, Jansen P, Benedetti A, Moshage H (2001) Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver 21:1\u201312","journal-title":"Liver"},{"key":"968_CR44","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2210-5-2","volume":"5","author":"N Tirkey","year":"2005","unstructured":"Tirkey N, Pilkhwal S, Kuhad A, Chopra K (2005) Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol 5:2. doi: 10.1186\/1471-2210-5-2","journal-title":"BMC Pharmacol"},{"key":"968_CR45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/hep.20326","volume":"40","author":"A Venkatraman","year":"2004","unstructured":"Venkatraman A, Shiva S, Wigley A, Ulasova E, Chhieng D, Bailey SM, Darley-Usmar VM (2004) The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice. Hepatology 40:565\u2013573. doi: 10.1002\/hep.20326","journal-title":"Hepatology"},{"key":"968_CR46","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jep.2009.10.001","volume":"127","author":"JH Wang","year":"2010","unstructured":"Wang JH, Shin JW, Son JY, Cho JH, Son CG (2010) Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats. J Ethnopharmacol 127:534\u2013542. doi: 10.1016\/j.jep.2009.10.001","journal-title":"J Ethnopharmacol"},{"key":"968_CR47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0009-8981(74)90357-X","volume":"53","author":"D Webster","year":"1974","unstructured":"Webster D, Bignell AH, Attwood EC (1974) An assessment of the suitability of bromocresol green for the determination of serum albumin. Clin Chim Acta 53:101\u2013108","journal-title":"Clin Chim Acta"},{"key":"968_CR48","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3748\/wjg.v7.i1.42","volume":"7","author":"HL Weng","year":"2001","unstructured":"Weng HL, Cai WM, Liu RH (2001) Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis. World J Gastroenterol 7:42\u201348","journal-title":"World J Gastroenterol"},{"key":"968_CR49","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1093\/carcin\/17.11.2385","volume":"17","author":"G Williamson","year":"1996","unstructured":"Williamson G, Plumb GW, Uda Y, Price KR, Rhodes MJ (1996) Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Carcinogenesis 17:2385\u20132387","journal-title":"Carcinogenesis"},{"key":"968_CR50","first-page":"1D","volume":"21","author":"DS Young","year":"1975","unstructured":"Young DS, Pestaner LC, Gibberman V (1975) Effects of drugs on clinical laboratory tests. Clin Chem 21:1D\u2013432D","journal-title":"Clin Chem"},{"key":"968_CR51","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/ptr.2449","volume":"22","author":"M Zielinska-Przyjemska","year":"2008","unstructured":"Zielinska-Przyjemska M, Ignatowicz E (2008) Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism. Phytother Res 22:1557\u20131562. doi: 10.1002\/ptr.2449","journal-title":"Phytother Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-014-0968-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-014-0968-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-014-0968-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T04:08:04Z","timestamp":1597550884000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-014-0968-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["968"],"URL":"https:\/\/doi.org\/10.1007\/s00210-014-0968-2","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]}}}