{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:02:17Z","timestamp":1740106937599,"version":"3.37.3"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004482","name":"Kuwait University","doi-asserted-by":"publisher","award":["SRU02\/13"],"award-info":[{"award-number":["SRU02\/13"]}],"id":[{"id":"10.13039\/501100004482","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00210-016-1223-9","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:08:05Z","timestamp":1456438085000},"page":"539-551","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lutein modulates transcription dysregulation of adhesion molecules and spermatogenesis transcription factors induced by testicular ischemia reperfusion injury: it could be SAFE"],"prefix":"10.1007","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-0485","authenticated-orcid":false,"given":"May","family":"Al-Maghrebi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed M.","family":"Renno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda F.","family":"Al-Somali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina S.","family":"Botras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman N.","family":"Qadhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"1223_CR1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00383-009-2538-0","volume":"26","author":"BK Akta\u015f","year":"2010","unstructured":"Akta\u015f BK, Bulut S, Bulut S, Baykam MM, Ozden C, Senes M, Y\u00fccel D, Memi\u015f A (2010) The effects of N-acetylcysteine on testicular damage in experimental testicular ischemia\/reperfusion injury. Pediatr Surg Int 26:293\u2013298","journal-title":"Pediatr Surg Int"},{"key":"1223_CR2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbrc.2010.04.012","volume":"395","author":"M Al-Maghrebi","year":"2010","unstructured":"Al-Maghrebi M, Kehinde EO, Anim JT (2010) Long term testicular ischemia-reperfusion injury-induced apoptosis: involvement of survivin down-regulation. Biochem Biophys Res Commun 395:342\u2013347","journal-title":"Biochem Biophys Res Commun"},{"key":"1223_CR3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bbrc.2012.03.013","volume":"420","author":"M Al-Maghrebi","year":"2012","unstructured":"Al-Maghrebi M, Renno WM, Al-Ajmi N (2012) Epigallocatechin-3-gallate inhibits apoptosis and protects testicular seminiferous tubules from ischemia\/reperfusion-induced inflammation. Biochem Biophys Res Commun 420:434\u2013439","journal-title":"Biochem Biophys Res Commun"},{"key":"1223_CR4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/evj.12013","volume":"45","author":"J Almeida","year":"2013","unstructured":"Almeida J, Conley AJ, Ball BA (2013) Expression of anti-M\u00fcllerian hormone, CDKN1B, connexin 43, androgen receptor and steroidogenic enzymes in the equine cryptorchid testis. Equine Vet J 45:538\u2013545","journal-title":"Equine Vet J"},{"key":"1223_CR5","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2174\/092986712799320538","volume":"19","author":"D Altavilla","year":"2012","unstructured":"Altavilla D, Romeo C, Squadrito F (2012) Molecular pathways involved in the early and late damage induced by testis ischemia: evidence for a rational pharmacological modulation. Curr Med Chem 19:1219\u20131224","journal-title":"Curr Med Chem"},{"key":"1223_CR6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2605.1994.tb01239.x","volume":"17","author":"A-M Andersson","year":"1994","unstructured":"Andersson A-M, Edvardsen K, Skakkebaek NE (1994) Expression and localization of N- and E-cadherin in the human testis and epididymis. Int J Androl 17:174\u2013180","journal-title":"Int J Androl"},{"key":"1223_CR7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/002215540004800608","volume":"48","author":"C Batias","year":"2000","unstructured":"Batias C, Siffroi JP, Fenichel P, Pointis G, Segretain D (2000) Connexin43 gene expression and regulation in the rodent seminiferous epithelium. J Histochem Cytochem 48:793\u2013805","journal-title":"J Histochem Cytochem"},{"key":"1223_CR8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF00300074","volume":"21","author":"ML Blank","year":"1993","unstructured":"Blank ML, O\u2019Neill PO, Steigman CK, Cobb LM, Wilde RA, Havenstein PJ, Chaudry IH (1993) Reperfusion injury following testicular torsion and detorsion in prepubertal rats. Urol Res 21:389\u2013393","journal-title":"Urol Res"},{"key":"1223_CR9","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1128\/MCB.20.8.2865-2873.2000","volume":"20","author":"MJ Bouchard","year":"2000","unstructured":"Bouchard MJ, Dong Y, McDermott BM Jr, Lam DH, Brown KR, Shelanski M, Bellv\u00e9 AR, Racaniello VR (2000) Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions. Mol Cell Biol 20:2865\u20132873","journal-title":"Mol Cell Biol"},{"key":"1223_CR10","first-page":"461","volume-title":"The Sertoli cell","author":"SW Byers","year":"1993","unstructured":"Byers SW, Jegou B, MacCalman C, Blaschuk OW (1993) Sertoli cell adhesion molecules and the collective organization of the testis. In: Russell LD, Griswold MD (eds) The Sertoli cell. Cache River, Clearwater, FL, pp 461\u2013476"},{"key":"1223_CR11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ydbio.2010.07.014","volume":"346","author":"D Carette","year":"2010","unstructured":"Carette D, Weider K, Gilleron J, Giese S, Dompierre J, Bergmann M, Brehm R, Denizot JP, Segretain D, Pointis G (2010) Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility. Dev Biol 346:54\u201367","journal-title":"Dev Biol"},{"key":"1223_CR12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/10409230903061207","volume":"44","author":"CY Cheng","year":"2009","unstructured":"Cheng CY, Mruk DD (2009) An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective. Crit Rev Biochem Mol Biol 44:245\u2013263","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"1223_CR13","doi-asserted-by":"crossref","first-page":"257S","DOI":"10.1093\/jn\/134.1.257S","volume":"134","author":"BP Chew","year":"2004","unstructured":"Chew BP, Park JS (2004) Carotenoid action on the immune response. J Nutr 134:257S\u2013261S","journal-title":"J Nutr"},{"key":"1223_CR14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2164\/jandrol.111.013664","volume":"33","author":"K Chiba","year":"2012","unstructured":"Chiba K, Kondo Y, Yamaguchi K, Miyake H, Fujisawa M (2012) Inhibition of claudin-11 and occludin expression in rat Sertoli cells by mono-(2-ethylhexyl) phthalate through p44\/42 mitogen-activated protein kinase pathway. J Androl 33:368\u2013374","journal-title":"J Androl"},{"key":"1223_CR15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.acthis.2011.06.006","volume":"114","author":"G Contuk","year":"2012","unstructured":"Contuk G, Orun O, Demiralp-Ek\u015fio\u011flu E, Ercan F (2012) Morphological alterations and distribution of occludin in rat testes after bilateral vasectomy. Acta Histochem 114:244\u2013251","journal-title":"Acta Histochem"},{"key":"1223_CR16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/01.LAB.0000059928.82702.6D","volume":"83","author":"N Defamie","year":"2003","unstructured":"Defamie N, Berthaut I, Mograbi B, Chevallier D, Dadoune JP, Fenichel P, Segretain D, Pointis G (2003) Impaired gap junction connexin43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells. Lab Invest 83:449\u2013456","journal-title":"Lab Invest"},{"key":"1223_CR17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1387\/ijdb.041793ld","volume":"48","author":"LD Derycke","year":"2004","unstructured":"Derycke LD, Bracke ME (2004) N-cadherin in the spotlight of cell cell adhesion, differentiation, embryogenesis, invasion and signalling. Int J Dev Biol 48:463\u2013476","journal-title":"Int J Dev Biol"},{"key":"1223_CR18","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.lfs.2007.01.040","volume":"80","author":"GA Deuchar","year":"2007","unstructured":"Deuchar GA, Opie LH, Lecour S (2007) TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning. Life Sci 80:1686\u20131691","journal-title":"Life Sci"},{"key":"1223_CR19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00253-009-2420-y","volume":"86","author":"JM Fernandez-Sevilla","year":"2010","unstructured":"Fernandez-Sevilla JM, Fernandez FGA, Grima EM (2010) Biotechnological production of lutein and its applications. Appl Micro Biotechnol 86:27\u201340","journal-title":"Appl Micro Biotechnol"},{"key":"1223_CR20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mam.2004.02.020","volume":"25","author":"DW Filho","year":"2004","unstructured":"Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A (2004) Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med 25:199\u2013210","journal-title":"Mol Aspects Med"},{"key":"1223_CR21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0303-7207(01)00463-4","volume":"179","author":"GM Fimia","year":"2001","unstructured":"Fimia GM, Morlon A, Macho B, De Cesare D, Sassone-Corsi P (2001) Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT. Mol Cell Endocrinol 179:17\u201323","journal-title":"Mol Cell Endocrinol"},{"key":"1223_CR22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/355080a0","volume":"355","author":"NS Foulkes","year":"1992","unstructured":"Foulkes NS, Mellstrom B, Benusiglio E et al (1992) Developmental switch of CREM function during spermatogenesis: from antagonist to activator. Nature 355:80\u201384","journal-title":"Nature"},{"key":"1223_CR23","first-page":"935","volume":"29","author":"J Gerber","year":"2014","unstructured":"Gerber J, Weider K, Hambruch N, Brehm R (2014) Loss of connexin43 (Cx43) in Sertoli cells leads to spatio-temporal alterations in occludin expression. Histol Histopathol 29:935\u201394","journal-title":"Histol Histopathol"},{"key":"1223_CR24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/molehr\/6.6.487","volume":"6","author":"LO Goodwin","year":"2000","unstructured":"Goodwin LO, Karabinus DS, Pergolizzi RG (2000) Presence of N-cadherin transcripts in mature spermatozoa. Mol Hum Reprod 6:487\u2013497","journal-title":"Mol Hum Reprod"},{"key":"1223_CR25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)81553-6","volume":"99","author":"A Gow","year":"1999","unstructured":"Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE, Danias J, Bronstein JM, Kachar B, Lazzarini RA (1999) CNS myelin and Sertoli cell tight junction strands are absent in Osp\/claudin-11 null mice. Cell 99:649\u2013659","journal-title":"Cell"},{"key":"1223_CR26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02738619","volume":"10","author":"DB Hales","year":"1999","unstructured":"Hales DB, Diemer T, Hales KH (1999) Role of cytokines in testicular function. Endocrine 10:201\u2013217","journal-title":"Endocrine"},{"key":"1223_CR27","first-page":"29","volume":"19","author":"WY Hao","year":"2013","unstructured":"Hao WY, Shao CH, Feng YL, Hu JT, Li Q, Wang HQ, Wang PT (2013) Hypoxia reduces the proliferation and occludin expression of primary sertoli cells. Zhonghua Nan Ke Xue 19:29\u201334","journal-title":"Zhonghua Nan Ke Xue"},{"key":"1223_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10915810701876265","volume":"27","author":"KB Harikumar","year":"2008","unstructured":"Harikumar KB, Nimita CV, Preethi KC, Kuttan R, Shankaranarayana ML, Deshpande J (2008) Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta). Int J Toxicol 27:1\u20139","journal-title":"Int J Toxicol"},{"key":"1223_CR29","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.fertnstert.2013.04.034","volume":"100","author":"JT Haverfield","year":"2013","unstructured":"Haverfield JT, Meachem SJ, O'Bryan MK, McLachlan RI, Stanton PG (2013) Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls. Fertil Steril 100:658\u2013666","journal-title":"Fertil Steril"},{"key":"1223_CR30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jemt.20783","volume":"73","author":"L Hermo","year":"2010","unstructured":"Hermo L, Pelletier RM, Cyr DG, Smith CE (2010) Surfing the wave, cycle, life history, and genes\/proteins expressed by testicular germ cells. Part 4: intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane\/voltage-gated channels, methylation\/acetylation, and transcription factors. Microsc Res Tech 73:364\u2013408","journal-title":"Microsc Res Tech"},{"key":"1223_CR31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000178170","volume":"1","author":"SG Johnsen","year":"1970","unstructured":"Johnsen SG (1970) Testicular biopsy score count\u2014a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1:2\u20132","journal-title":"Hormones"},{"key":"1223_CR32","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1073\/pnas.0709854105","volume":"105","author":"DS Johnston","year":"2008","unstructured":"Johnston DS, Wright WW, Dicandeloro P, Wilson E, Kopf GS, Jelinsky SA (2008) Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells. Proc Natl Acad Sci U S A 105:8315\u20138320","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1223_CR33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrurol.2014.135","volume":"11","author":"E Karaguzel","year":"2014","unstructured":"Karaguzel E, Kadihasanoglu M, Kutlu O (2014) Mechanisms of testicular torsion and potential protective agents. Nat Rev Urol 11:391\u2013399","journal-title":"Nat Rev Urol"},{"key":"1223_CR34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.preteyeres.2012.03.002","volume":"31","author":"A Kijlstra","year":"2012","unstructured":"Kijlstra A, Tian Y, Kelly ER, Berendschot TT (2012) Lutein: more than just a filter for blue light. Prog Retin Eye Res 31:303\u2013315","journal-title":"Prog Retin Eye Res"},{"key":"1223_CR35","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.freeradbiomed.2008.06.019","volume":"45","author":"JH Kim","year":"2008","unstructured":"Kim JH, Na HJ, Kim CK, Kim JY, Ha KS, Lee H, Chung HT, Kwon HJ, Kwon YG, Kim YM (2008) The non-provitarnin A carotenoid, lutein, inhibits NF-kappa B-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase\/PTEN\/Akt and NF-kappa B-inducing kinase pathways: role of H2O2 in NF-kappa B activation. Free Radic Biol Med 45:885\u2013896","journal-title":"Free Radic Biol Med"},{"key":"1223_CR36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1530\/rep.1.00170","volume":"128","author":"S Kimmins","year":"2004","unstructured":"Kimmins S, Kotaja N, Davidson I, Sassone-Corsi P (2004) Testis-specific transcription mechanisms promoting male germ-cell differentiation. Reproduction 128:5\u201312","journal-title":"Reproduction"},{"key":"1223_CR37","doi-asserted-by":"crossref","first-page":"e1005368","DOI":"10.1371\/journal.pgen.1005368","volume":"11","author":"WS Kistler","year":"2015","unstructured":"Kistler WS, Baas D, Lemeille S, Paschaki M, Seguin-Estevez Q, Barras E, Ma W, Duteyrat JL, Morl\u00e9 L, Durand B, Reith W (2015) RFX2 is a major transcriptional regulator of spermiogenesis. PLoS Genet 11:e1005368\u20131005396","journal-title":"PLoS Genet"},{"key":"1223_CR38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.nutr.23.011702.073307","volume":"23","author":"NI Krinsky","year":"2003","unstructured":"Krinsky NI, Landrum JT, Bone RA (2003) Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr 23:171\u2013201","journal-title":"Annu Rev Nutr"},{"key":"1223_CR39","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1095\/biolreprod.111.092379","volume":"85","author":"C Lachance","year":"2011","unstructured":"Lachance C, Leclerc P (2011) Mediators of the Jak\/STAT signaling pathway in human spermatozoa. Biol Reprod 85:1222\u201312231","journal-title":"Biol Reprod"},{"key":"1223_CR40","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/jcp.24215","volume":"228","author":"C Lachance","year":"2013","unstructured":"Lachance C, Goupil S, Leclerc P (2013) Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity. J Cell Physiol 228:704\u2013713","journal-title":"J Cell Physiol"},{"key":"1223_CR41","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1161\/CIRCULATIONAHA.105.581058","volume":"112","author":"S Lecour","year":"2005","unstructured":"Lecour S, Suleman N, Deuchar GA, Somers S, Lacerda L, Huisamen B, Opie LH (2005) Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase). Circulation 112:3911\u20133918","journal-title":"Circulation"},{"key":"1223_CR42","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.yjmcc.2009.01.003","volume":"46","author":"S Lecour","year":"2009","unstructured":"Lecour S (2009) Multiple protective pathways against reperfusion injury: a SAFE path without Aktion? J Mol Cell Cardiol 46:607\u2013609","journal-title":"J Mol Cell Cardiol"},{"key":"1223_CR43","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1167\/iovs.08-2310","volume":"50","author":"SY Li","year":"2009","unstructured":"Li SY, Fu ZJ, Ma H, Jang WC, So KF, Wong D, Lo ACY (2009) Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia\/reperfusion. Invest Ophthalmol Vis Sci 50:836\u2013843","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1223_CR44","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.nbd.2011.10.008","volume":"45","author":"SY Li","year":"2012","unstructured":"Li SY, Yang D, Fu ZJ, Woo T, Wong D, Lo AC (2012) Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis 45:624\u2013632","journal-title":"Neurobiol Dis"},{"key":"1223_CR45","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.3892\/mmr.2014.2982","volume":"11","author":"ZG Liu","year":"2015","unstructured":"Liu ZG, Qi ZC, Liu WL, Wang WZ (2015) Lutein protects against ischemia\/reperfusion injury in rat kidneys. Mol Med Rep 11:2179\u20132184","journal-title":"Mol Med Rep"},{"key":"1223_CR46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mce.2005.12.021","volume":"16","author":"WY Lui","year":"2006","unstructured":"Lui WY, Lee WM (2006) Regulation of junction dynamics in the testis\u2014transcriptional and post-translational regulations of cell junction proteins. Mol Cell Endocrinol 16:25\u201335","journal-title":"Mol Cell Endocrinol"},{"key":"1223_CR47","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"1223_CR48","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1095\/biolreprod.102.013318","volume":"69","author":"JJ Lysiak","year":"2003","unstructured":"Lysiak JJ, Nguyen QAT, Kirby JL, Turner TT (2003) Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression. Biol Reprod 69:202\u2013210","journal-title":"Biol Reprod"},{"key":"1223_CR49","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0002-8223(93)91553-3","volume":"93","author":"AR Mangels","year":"1993","unstructured":"Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E (1993) Carotenoid content of fruits and vegetables: an evaluation of analytic data. J Am Diet Assoc 93:284\u2013296","journal-title":"J Am Diet Assoc"},{"key":"1223_CR50","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.physiol.65.092101.142249","volume":"65","author":"DL Mann","year":"2003","unstructured":"Mann DL (2003) Stress-activated cytokines and the heart: from adaptation to maladaptation. Annu Rev Physiol 65:81\u2013101","journal-title":"Annu Rev Physiol"},{"key":"1223_CR51","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1097-2765(01)00198-8","volume":"7","author":"I Martianov","year":"2001","unstructured":"Martianov I, Fimia GM, Dierich A, Parvinen M, Sassone-Corsi P, Davidson I (2001) Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF\/TRF2 gene. Mol Cell 7:509\u2013515","journal-title":"Mol Cell"},{"key":"1223_CR52","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1095\/biolreprod.109.078907","volume":"82","author":"S Mazaud-Guittot","year":"2010","unstructured":"Mazaud-Guittot S, Meugnier E, Pesenti S, Wu X, Vidal H, Gow A, Le Magueresse-Battistoni B (2010) Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis. Biol Reprod 82:202\u2013213","journal-title":"Biol Reprod"},{"key":"1223_CR53","first-page":"1","volume":"13","author":"F Mehraein","year":"2011","unstructured":"Mehraein F, Negahdar F (2011) Morphometric evaluation of seminiferous tubules in aged mice testes after melatonin administration. Cell J 13:1\u20134","journal-title":"Cell J"},{"key":"1223_CR54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1095\/biolreprod59.2.371","volume":"59","author":"A Meinhardt","year":"1998","unstructured":"Meinhardt A, Bacher M, Metz C, Bucala R, Wreford N, Lan H, Atkins R, Hedger M (1998) Local regulation of macrophage subsets in the adult rat testis: examination of the roles of the seminiferous tubules, testosterone, and macrophage-migration inhibitory factor. Biol Reprod 59:371\u2013378","journal-title":"Biol Reprod"},{"key":"1223_CR55","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1083\/jcb.145.3.579","volume":"145","author":"K Morita","year":"1991","unstructured":"Morita K, Sasaki H, Fujimoto K, Furuse M, Tsukita S (1991) Claudin-11\/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol 145:579\u2013588","journal-title":"J Cell Biol"},{"key":"1223_CR56","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1095\/biolreprod.102.014670","volume":"69","author":"S Mueller","year":"2003","unstructured":"Mueller S, Rosenquist TA, Takai Y, Bronson RA, Wimmer E (2003) Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration. Biol Reprod 69:1330\u20131340","journal-title":"Biol Reprod"},{"key":"1223_CR57","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.modgep.2004.12.007","volume":"5","author":"K Murphy","year":"2005","unstructured":"Murphy K, Carvajal L, Medico L, Pepling M (2005) Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes. Gene Expr Patterns 5:475\u2013482","journal-title":"Gene Expr Patterns"},{"key":"1223_CR58","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.fertnstert.2010.08.023","volume":"95","author":"WH Nah","year":"2011","unstructured":"Nah WH, Lee JE, Park HJ, Park NC, Gye MC (2011) Claudin-11 expression increased in spermatogenic defect in human testes. Fertil Steril 95:385\u2013388","journal-title":"Fertil Steril"},{"key":"1223_CR59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1369\/0022155414562045","volume":"63","author":"H Nakata","year":"2015","unstructured":"Nakata H, Wakayama T, Takai Y, Iseki S (2015) Quantitative analysis of the cellular composition in seminiferous tubules in normal and genetically modified infertile mice. J Histochem Cytochem 63:99\u2013113","journal-title":"J Histochem Cytochem"},{"key":"1223_CR60","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/380159a0","volume":"380","author":"F Nantel","year":"1996","unstructured":"Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksen K, Dietrich A, Parvinen M, Sassone-Corsi P (1996) Spermtogenesis deficiency and germ cell apoptosis in CREM-mutant mice. Nature 380:159\u2013162","journal-title":"Nature"},{"key":"1223_CR61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/aja.1001970102","volume":"197","author":"SC Newton","year":"1993","unstructured":"Newton SC, Blaschuk OW, Millette CF (1993) N-cadherin mediates Sertoli cell-spermatogenic cell adhesion. Dev Dynam 197:1\u201313","journal-title":"Dev Dynam"},{"key":"1223_CR62","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1248\/bpb.29.1764","volume":"29","author":"W Ogura","year":"2006","unstructured":"Ogura W, Itagaki S, Kurokawa T, Noda T, Hirano T, Mizuno S, Iseki K (2006) Protective effect of lutein on ischemia-reperfusion injury in rat small intestine. Biol Pharm Bull 29:1764\u20131766","journal-title":"Biol Pharm Bull"},{"key":"1223_CR63","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0891-5849(93)90037-U","volume":"15","author":"F Ojima","year":"1993","unstructured":"Ojima F, Sakamoto H, Ishiguro Y, Terao J (1993) Consumption of carotenoids in photosensitized oxidation of human plasma and plasma low-density lipoprotein. Free Radic Biol Med 15:377\u2013384","journal-title":"Free Radic Biol Med"},{"key":"1223_CR64","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0960-9822(02)00922-3","volume":"12","author":"K Ozaki-Kuroda","year":"2002","unstructured":"Ozaki-Kuroda K, Nakanishi H, Ohta H, Tanaka H, Kurihara H, Mueller S, Irie K, Ikeda W, Sakai T, Wimmer E, Nishimune Y, Takai Y (2002) Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Curr Biol 12:1145\u20131150","journal-title":"Curr Biol"},{"key":"1223_CR65","doi-asserted-by":"crossref","first-page":"e84354","DOI":"10.1371\/journal.pone.0084354","volume":"8","author":"C Paul","year":"2013","unstructured":"Paul C, Robaire B (2013) Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases. PLoS ONE 8:e84354\u2013e84363","journal-title":"PLoS ONE"},{"key":"1223_CR66","first-page":"4480","volume":"86","author":"V Pentikainen","year":"2001","unstructured":"Pentikainen V, Erkkila K, Suomalainen L, Otala M, Pentikainen MO, Parvinen M, Dunkel L (2001) TNFa down-regulates the Fas ligand and inhibits germ cell apoptosis in the human testis. J Clin Endocrinol Metab 86:4480\u20134488","journal-title":"J Clin Endocrinol Metab"},{"key":"1223_CR67","doi-asserted-by":"crossref","first-page":"567S","DOI":"10.1080\/07315724.2004.10719427","volume":"23","author":"JD Ribaya-Mercado","year":"2004","unstructured":"Ribaya-Mercado JD, Blumberg JB (2004) Lutein and zeaxanthin and their potential roles in disease prevention. J Am Coll Nutr 23:567S\u2013587S","journal-title":"J Am Coll Nutr"},{"key":"1223_CR68","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1091\/mbc.11.12.4131","volume":"11","author":"M Saitou","year":"2000","unstructured":"Saitou M, Furuse M, Sasaki H, Schulzke JD, Fromm M, Takano H, Noda T, Tsukita S (2000) Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 11:4131\u20134142","journal-title":"Mol Biol Cell"},{"key":"1223_CR69","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/(SICI)1098-2795(200006)56:2+<228::AID-MRD2>3.0.CO;2-B","volume":"56","author":"P Sassone-Corsi","year":"2000","unstructured":"Sassone-Corsi P (2000) CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells. Mol Reprod Dev 56:228\u2013229","journal-title":"Mol Reprod Dev"},{"key":"1223_CR70","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1210\/en.2002-220786","volume":"144","author":"MKY Siu","year":"2003","unstructured":"Siu MKY, Lee WM, Cheng CY (2003) The interplay of collagen IV, tumor necrosis factor-a, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis. Endocrinology 144:371\u2013387","journal-title":"Endocrinology"},{"key":"1223_CR71","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/bjo.82.8.907","volume":"82","author":"O Sommerburg","year":"1998","unstructured":"Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ (1998) Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol 82:907\u2013910","journal-title":"Br J Ophthalmol"},{"key":"1223_CR72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.abb.2010.05.015","volume":"27","author":"WK Subczynski","year":"2010","unstructured":"Subczynski WK, Wisniewska A, Widomska J (2010) Location of macular xanthophylls in the most vulnerable regions of photoreceptor outer-segment membranes. Arch Biochem Biophys 27:61\u201366","journal-title":"Arch Biochem Biophys"},{"key":"1223_CR73","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1095\/biolreprod.102.011189","volume":"68","author":"MO Suescun","year":"2003","unstructured":"Suescun MO, Rival C, Theas MS, Calandra RS, Lustig L (2003) Involvement of tumor necrosis factor-alpha in the pathogenesis of autoimmune orchitis in rats. Biol Reprod 68:2114\u20132121","journal-title":"Biol Reprod"},{"key":"1223_CR74","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/cvr\/cvn067","volume":"79","author":"N Suleman","year":"2008","unstructured":"Suleman N, Somers S, Smith R, Opie LH, Lecour SC (2008) Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning. Cardiovasc Res 79:127\u2013133","journal-title":"Cardiovasc Res"},{"key":"1223_CR75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/jcs.00167","volume":"116","author":"Y Takai","year":"2003","unstructured":"Takai Y, Nakanishi H (2003) Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 116:17\u201327","journal-title":"J Cell Sci"},{"key":"1223_CR76","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ydbio.2007.09.029","volume":"312","author":"M Takehashi","year":"2007","unstructured":"Takehashi M, Kanatsu-Shinohara M, Miki H, Lee J, Kazuki Y, Inoue K, Ogonuki N, Toyokuni S, Oshimura M, Ogura A, Shinohara T (2007) Production of knockout mice by gene targeting in multipotent germline stem cells. Dev Biol 312:344\u2013352","journal-title":"Dev Biol"},{"key":"1223_CR77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.toxlet.2003.10.031","volume":"150","author":"A ves-Rodrigues","year":"2004","unstructured":"ves-Rodrigues A, Shao A (2004) The science behind lutein. Toxicol Lett 150:57\u201383","journal-title":"Toxicol Lett"},{"key":"1223_CR78","first-page":"353","volume":"11","author":"DW Warren","year":"1990","unstructured":"Warren DW, Pasupuleti V, Lu Y, Platter BW, Horton R (1990) Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro. J Androl 11:353\u2013360","journal-title":"J Androl"},{"key":"1223_CR79","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.fertnstert.2007.04.044","volume":"89","author":"SM Wei","year":"2008","unstructured":"Wei SM, Yan ZZ, Zhou J (2008) Role of cAMP-responsive element modulator tau (CREMtau) in ipsilateral testicular injury after unilateral testicular torsion-detorsion. Fertil Steril 89:1737\u20131742","journal-title":"Fertil Steril"},{"key":"1223_CR80","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0070-2153(05)71008-5","volume":"71","author":"CH Wong","year":"2005","unstructured":"Wong CH, Cheng CY (2005) The blood\u2013testis barrier: its biology, regulation, and physiological role in spermatogenesis. Curr Top Dev Biol 71:263\u2013296","journal-title":"Curr Top Dev Biol"},{"key":"1223_CR81","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tips.2011.01.001","volume":"32","author":"EW Wong","year":"2011","unstructured":"Wong EW, Cheng CY (2011) Impacts of environmental toxicants on male reproductive dysfunction. Trends Pharmacol Sci 32:290\u2013299","journal-title":"Trends Pharmacol Sci"},{"key":"1223_CR82","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00417-012-2128-z","volume":"251","author":"TT Woo","year":"2013","unstructured":"Woo TT, Li SY, Lai WW, Wong D, Lo AC (2013) Neuroprotective effects of lutein in a rat model of retinal detachment. Graefes Arch Clin Exp Ophthalmol 251:41\u201351","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1223_CR83","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0022-5347(17)48926-9","volume":"133","author":"JP York","year":"1985","unstructured":"York JP, Drago JR (1985) Torsion and contralateral testicle. J Urol 133:294\u2013297","journal-title":"J Urol"},{"key":"1223_CR84","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1210\/endo.133.3.8103448","volume":"133","author":"TD Yule","year":"1993","unstructured":"Yule TD, Tung KSK (1993) Experimental autoimmune orchitis induced by testis and sperm antigen-specific T cell clones: an important pathogenic cytokine is tumor necrosis factor. Endocrinology 133:1098\u20131107","journal-title":"Endocrinology"},{"key":"1223_CR85","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1126\/science.1059188","volume":"292","author":"D Zhang","year":"2001","unstructured":"Zhang D, Penttila TL, Morris PL, Teichmann M, Roeder RG (2001) Spermiogenesis deficiency in mice lacking the TRF2 gene. Science 292:1153\u20131155","journal-title":"Science"},{"key":"1223_CR86","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1210\/en.2004-1194","volume":"146","author":"J Zhang","year":"2005","unstructured":"Zhang J, Wong CH, Xia W, Mruk DD, Lee NPY, Lee WM, Cheng CY (2005) Regulation of Sertoli\u2013germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-b-catenin protein complex which are possibly mediated by c-Src and MTMR2: an in vivo study using an androgen suppression model. Endocrinology 146:1268\u20131284","journal-title":"Endocrinology"},{"key":"1223_CR87","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1530\/REP-12-0336","volume":"145","author":"S Zhang","year":"2013","unstructured":"Zhang S, Zeng Y, Qu J, Luo Y, Wang X, Li W (2013a) Endogenous EGF maintains Sertoli germ cell anchoring junction integrity and is required for early recovery from acute testicular ischemia\/reperfusion injury. Reproduction 145:177\u2013189","journal-title":"Reproduction"},{"key":"1223_CR88","first-page":"306","volume":"19","author":"WX Zhang","year":"2013","unstructured":"Zhang WX, Qin JC, Wang R, Wang L, Zhang J (2013b) Radiation-induced oxidative stress and claudin-11 mRNA expression in the testis. Zhonghua Nan Ke Xue 19:306\u2013310","journal-title":"Zhonghua Nan Ke Xue"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-016-1223-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-016-1223-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-016-1223-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T20:49:46Z","timestamp":1567630186000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-016-1223-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":88,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1223"],"URL":"https:\/\/doi.org\/10.1007\/s00210-016-1223-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"type":"print","value":"0028-1298"},{"type":"electronic","value":"1432-1912"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}