{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:36:06Z","timestamp":1793039766615,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26450407"],"award-info":[{"award-number":["26450407"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s00210-017-1396-x","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T08:40:47Z","timestamp":1498552847000},"page":"929-938","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Rho-kinase and the nitric oxide pathway modulate basilar arterial reactivity to acetylcholine and angiotensin II in streptozotocin-induced diabetic mice"],"prefix":"10.1007","volume":"390","author":[{"given":"Md. Zahorul","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong","family":"Van Dao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuya","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"1396_CR1","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s00210-014-1048-3","volume":"387","author":"H Adel","year":"2014","unstructured":"Adel H, Taye A, Khalifa MM (2014) Spironolactone improves endothelial dysfunction in streptozotocin-induced diabetic rats. Naunyn Schmiedeberg\u2019s Arch Pharmacol 387:1187\u20131197. doi:\n                    10.1007\/s00210-014-1048-3","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"1396_CR2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.brainres.2008.03.020","volume":"1209","author":"DM Arrick","year":"2008","unstructured":"Arrick DM, Sharpe GM, Sun H, Mayhan WG (2008) Losartan improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type 1 diabetic rats. Brain Res 1209:128\u2013135. doi:\n                    10.1016\/j.brainres.2008.03.020","journal-title":"Brain Res"},{"key":"1396_CR3","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1161\/01.ATV.0000172688.26838.9f","volume":"25","author":"Z Bagi","year":"2005","unstructured":"Bagi Z, Erdei N, Toth A, Li W, Hintze TH, Koller A, Kaley G (2005) Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins. Arterioscler Thromb Vasc Biol 25:1610\u20131616. doi:\n                    10.1161\/01.ATV.0000172688.26838.9f","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1396_CR4","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1111\/j.1476-5381.2011.01307.x","volume":"163","author":"Z Bagi","year":"2011","unstructured":"Bagi Z, Feher A, Cassuto J, Akula K, Labinskyy N, Kaley G, Koller A (2011) Increased availability of angiotensin AT1 receptors leads to sustained arterial constriction to angiotensin II in diabetes\u2014role for rho-kinase activation. Br J Pharmacol 163:1059\u20131068. doi:\n                    10.1111\/j.1476-5381.2011.01307.x","journal-title":"Br J Pharmacol"},{"key":"1396_CR5","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1161\/01.RES.0000014489.24705.71","volume":"90","author":"S Besnard","year":"2002","unstructured":"Besnard S, Bakouche J, Lemaigre-Dubreuil Y, Mariani J, Tedgui A, Henrion D (2002) Smooth muscle dysfunction in resistance arteries of the staggerer mouse, a mutant of the nuclear receptor ROR\u03b1. Circ Res 90:820\u2013825. doi:\n                    10.1161\/01.RES.0000014489.24705.71","journal-title":"Circ Res"},{"key":"1396_CR6","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1161\/01.RES.69.4.989","volume":"69","author":"PJ Boels","year":"1991","unstructured":"Boels PJ, Troschka M, R\u00fcegg JC, Pfitzer G (1991) Higher Ca2+ sensitivity of triton-skinned guinea pig mesenteric microarteries as compared with large arteries. Circ Res 69:989\u2013996. doi:\n                    10.1161\/01.RES.69.4.989","journal-title":"Circ Res"},{"key":"1396_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1475-2840-13-88","volume":"13","author":"B Chen","year":"2014","unstructured":"Chen B, Zhao Q, Ni R, Tang F, Shan L, Cepinskas I, Cepinskas G, Wang W, Schiller PW, Peng T (2014) Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes. Cardiovasc Diabetol 13:88. doi:\n                    10.1186\/1475-2840-13-88","journal-title":"Cardiovasc Diabetol"},{"key":"1396_CR8","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1161\/hy02t2.102960","volume":"39","author":"K Chitaley","year":"2002","unstructured":"Chitaley K, Webb RC (2002) Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling. Hypertension 39:438\u2013442. doi:\n                    10.1161\/hy02t2.102960","journal-title":"Hypertension"},{"key":"1396_CR9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.2337\/diab.25.4.268","volume":"25","author":"AR Christlieb","year":"1976","unstructured":"Christlieb AR, Janka HU, Kraus B, Gleason RE, Icasas-Cabral EA, Aiello LM, Cabral BV, Solano A (1976) Vascular reactivity to angiotensin II and to norepinephrine in diabetic subjects. Diabetes 25:268\u2013274. doi:\n                    10.2337\/diab.25.4.268","journal-title":"Diabetes"},{"key":"1396_CR10","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1152\/ajpheart.00939.2006","volume":"292","author":"SP Didion","year":"2007","unstructured":"Didion SP, Lynch CM, Faraci FM (2007) Cerebral vascular dysfunction in TallyHO mice: a new model of type II diabetes. Am J Physiol Heart Circ Physiol 292:1579\u20131583. doi:\n                    10.1152\/ajpheart.00939.2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1396_CR11","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1161\/01.STR.0000152952.42730.92","volume":"36","author":"SP Didion","year":"2005","unstructured":"Didion SP, Lynch CM, Baumbach GL, Faraci FM (2005) Impaired endothelium-dependent responses and enhanced influence of rho-kinase in cerebral arterioles in type II diabetes. Stroke 36:342\u2013347. doi:\n                    10.1161\/01.STR.0000152952.42730.92","journal-title":"Stroke"},{"key":"1396_CR12","doi-asserted-by":"publisher","first-page":"247861","DOI":"10.1155\/2010\/247861","volume":"2010","author":"AB El-Remessy","year":"2010","unstructured":"El-Remessy AB, Tawfik HE, Matragoon S, Pillai B, Caldwell RB, Caldwell RW (2010) Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of rho kinase activation. Exp Diabetes Res 2010:247861. doi:\n                    10.1155\/2010\/247861","journal-title":"Exp Diabetes Res"},{"key":"1396_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/sj.jcbfm.9600204","volume":"26","author":"FM Faraci","year":"2006","unstructured":"Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Sigmund CD, Didion SP (2006) Cerebral vascular effects of angiotensin II: new insights from genetic models. J Cereb Blood Flow Metab 26:449\u2013455. doi:\n                    10.1038\/sj.jcbfm.9600204","journal-title":"J Cereb Blood Flow Metab"},{"key":"1396_CR14","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0140-6736(12)60987-8","volume":"380","author":"E Ferrannini","year":"2012","unstructured":"Ferrannini E, Cushman WC (2012) Diabetes and hypertension: the bad companions. Lancet 380:601\u2013610. doi:\n                    10.1016\/S0140-6736(12)60987-8","journal-title":"Lancet"},{"key":"1396_CR15","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.cardiores.2005.04.008","volume":"67","author":"Z Guo","year":"2005","unstructured":"Guo Z, Su W, Allen S, Pang H, Daugherty A, Smart E, Gong MC (2005) COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db\/db mice. Cardiovasc Res 67:723\u2013735. doi:\n                    10.1016\/j.cardiores.2005.04.008","journal-title":"Cardiovasc Res"},{"key":"1396_CR16","first-page":"853","volume":"3","author":"HA Hadi","year":"2007","unstructured":"Hadi HA, Suwaidi JA (2007) Endothelial dysfunction in diabetes mellitus. Vasc Health Risk Manag 3:853\u2013876","journal-title":"Vasc Health Risk Manag"},{"key":"1396_CR17","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2174\/157016106777698469","volume":"l4","author":"MA Haidara","year":"2006","unstructured":"Haidara MA, Yassin HZ, Rateb M, Ammar H, Zorkani MA (2006) Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Curr Vasc Pharmaco l4:215\u2013227. doi:\n                    10.2174\/157016106777698469","journal-title":"Curr Vasc Pharmaco"},{"key":"1396_CR18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00210-012-0822-3","volume":"386","author":"N Hassan","year":"2013","unstructured":"Hassan N, El-Bassossy HM, Zakaria MN (2013) Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility. Naunyn Schmiedeberg's Arch Pharmacol 386:217\u2013226. doi:\n                    10.1007\/s00210-012-0822-3","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"1396_CR19","first-page":"1438","volume":"257","author":"MA Hill","year":"1989","unstructured":"Hill MA, Larkins RG (1989) Altered microvascular reactivity in streptozotocin-induced diabetes in rats. Am J Phys 257:1438\u20131445","journal-title":"Am J Phys"},{"key":"1396_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.lfs.2016.01.033","volume":"147","author":"MZ Islam","year":"2016","unstructured":"Islam MZ, Van Dao C, Shiraishi M, Miyamoto A (2016) Methylmercury affects cerebrovascular reactivity to angiotensin II and acetylcholine via rho-kinase and nitric oxide pathways in mice. Life Sci 147:30\u201338. doi:\n                    10.1016\/j.lfs.2016.01.033","journal-title":"Life Sci"},{"key":"1396_CR21","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1292\/jvms.14-0223","volume":"76","author":"MZ Islam","year":"2014","unstructured":"Islam MZ, Watanabe Y, Nguyen HT, Yamazaki-Himeno E, Obi T, Shiraishi M, Miyamoto A (2014) Vasomotor effects of acetylcholine, bradykinin, noradrenaline, 5-hydroxytryptamine, histamine and angiotensin II on the mouse basilar artery. J Vet Med Sci 76:1339\u20131345. doi:\n                    10.1292\/jvms.14-0223","journal-title":"J Vet Med Sci"},{"key":"1396_CR22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2005.05.026","volume":"185","author":"T Kobayashi","year":"2006","unstructured":"Kobayashi T, Oishi K, Hayashi Y, Matsumoto T, Kamata K (2006) Changes in aortic endothelial gene expression and relaxation responses following chronic short-term insulin treatment in diabetic rats. Atherosclerosis 185:47\u201357. doi:\n                    10.1016\/j.atherosclerosis.2005.05.026","journal-title":"Atherosclerosis"},{"key":"1396_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ecl.2013.09.007","volume":"43","author":"JC Kovacic","year":"2014","unstructured":"Kovacic JC, Castellano JM, Farkouh ME, Fuster V (2014) The relationships between cardiovascular disease and diabetes: focus on pathogenesis. Endocrinol Metab Clin N Am 43:41\u201357. doi:\n                    10.1016\/j.ecl.2013.09.007","journal-title":"Endocrinol Metab Clin N Am"},{"key":"1396_CR24","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrendo.2014.29","volume":"10","author":"M Laakso","year":"2014","unstructured":"Laakso M, Kuusisto J (2014) Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol 10:293\u2013302. doi:\n                    10.1038\/nrendo.2014.29","journal-title":"Nat Rev Endocrinol"},{"key":"1396_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ejphar.2011.03.018","volume":"659","author":"CH Leo","year":"2011","unstructured":"Leo CH, Hart JL, Woodman OL (2011) 3\u2032,4\u2032-Dihydroxyflavonol restores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes. Eur J Pharmacol 659:193\u2013198. doi:\n                    10.1016\/j.ejphar.2011.03.018","journal-title":"Eur J Pharmacol"},{"key":"1396_CR26","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1161\/01.RES.0000201960.04223.3c","volume":"98","author":"G Loirand","year":"2006","unstructured":"Loirand G, Guerin P, Pacaud P (2006) Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 98:322\u2013334. doi:\n                    10.1161\/01.RES.0000201960.04223.3c","journal-title":"Circ Res"},{"key":"1396_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/1479164116675490","volume":"14","author":"WG Mayhan","year":"2017","unstructured":"Mayhan WG, Arrick DM (2017) Tetrahydrobiopterin rescues impaired responses of cerebral resistance arterioles during type 1 diabetes. Diab Vasc Dis Res 14:33\u201339. doi:\n                    10.1177\/1479164116675490","journal-title":"Diab Vasc Dis Res"},{"key":"1396_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1042\/cs0870031","volume":"87","author":"PG McNally","year":"1994","unstructured":"McNally PG, Watt PA, Rimmer T, Burden AC, Hearnshaw JR, Thurston H (1994) Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes diabetes mellitus. Clin Sci (Lond) 87:31\u201336","journal-title":"Clin Sci (Lond)"},{"key":"1396_CR29","doi-asserted-by":"publisher","unstructured":"Merlini M, Shi Y, Keller S, Savarese G, Akhmedov A, Derungs R, Spescha RD, Kulic L, Nitsch RM, L\u00fcscher TF, Camici GG (2016) Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer\u2019s disease. Am J Physiol Heart Circ Physiol doi. doi:\n                    10.1152\/ajpheart.00607.2016","DOI":"10.1152\/ajpheart.00607.2016"},{"key":"1396_CR30","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00210-008-0261-3","volume":"377","author":"T Miike","year":"2008","unstructured":"Miike T, Kunishiro K, Kanda M, Azukizawa S, Kurahashi K, Shirahase H (2008) Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db\/db mice\u2014possible dysfunction of receptor and\/or receptor-G protein coupling. Naunyn Schmiedeberg\u2019s Arch Pharmacol 377:401\u2013410. doi:\n                    10.1007\/s00210-008-0261-3","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"1396_CR31","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1152\/ajpheart.00987.2008","volume":"296","author":"AA Miller","year":"2009","unstructured":"Miller AA, Drummond GR, De Silva TM, Mast AE, Hickey H, Williams JP, Broughton BR, Sobey CG (2009) NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. Am J Physiol Heart Circ Physiol 296:220\u2013225. doi:\n                    10.1152\/ajpheart.00987.2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1396_CR32","doi-asserted-by":"publisher","first-page":"8467","DOI":"10.1128\/MCB.22.24.8467-8477.2002","volume":"22","author":"XF Ming","year":"2002","unstructured":"Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang Z (2002) Rho GTPase\/rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B\/Akt in human endothelial cells. Mol Cell Biol 22:8467\u20138477. doi:\n                    10.1128\/MCB.22.24.8467-8477.2002","journal-title":"Mol Cell Biol"},{"key":"1396_CR33","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.vph.2006.06.018","volume":"46","author":"A Miyamoto","year":"2007","unstructured":"Miyamoto A, Hashiguchi Y, Obi T, Ishiguro S, Nishio A (2007) Ibuprofen or ozagrel increases NO release and L-nitro arginine induces TXA2 release from cultured porcine basilar arterial endothelial cells. Vasc Pharmacol 46:85\u201390. doi:\n                    10.1016\/j.vph.2006.06.018","journal-title":"Vasc Pharmacol"},{"key":"1396_CR34","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1210\/en.2008-1069","volume":"150","author":"C Nacci","year":"2009","unstructured":"Nacci C, Tarquinio M, De Benedictis L, Mauro A, Zigrino A, Carrat\u00f9 MR, Quon MJ, Montagnani M (2009) Endothelial dysfunction in mice with streptozotocin-induced type 1 diabetes is opposed by compensatory over expression of cyclooxygenase-2 in the vasculature. Endocrinology 150:849\u2013861. doi:\n                    10.1210\/en.2008-1069","journal-title":"Endocrinology"},{"key":"1396_CR35","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1093\/cvr\/cvs422","volume":"97","author":"H Nguyen","year":"2013","unstructured":"Nguyen H, Chiasson VL, Chatterjee P, Kopriva SE, Young KJ, Mitchell BM (2013) Interleukin-17 causes rho-kinase-mediated endothelial dysfunction and hypertension. Cardiovasc Res 97:696\u2013704. doi:\n                    10.1093\/cvr\/cvs422","journal-title":"Cardiovasc Res"},{"key":"1396_CR36","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.neuroscience.2012.07.018","volume":"222","author":"R Ning","year":"2012","unstructured":"Ning R, Chopp M, Yan T, Zacharek A, Zhang C, Roberts C, Cui X, Lu M, Chen J (2012) Tissue plasminogen activator treatment of stroke in type-1 diabetes rats. Neuroscience 222:326\u2013332. doi:\n                    10.1016\/j.neuroscience.2012.07.018","journal-title":"Neuroscience"},{"key":"1396_CR37","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1111\/j.1476-5381.1996.tb16732.x","volume":"117","author":"Y Nishimura","year":"1996","unstructured":"Nishimura Y (1996) Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. Br J Pharmacol 117:1325\u20131133","journal-title":"Br J Pharmacol"},{"key":"1396_CR38","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ejphar.2012.03.022","volume":"683","author":"K Nobe","year":"2012","unstructured":"Nobe K, Hashimoto T, Honda K (2012) Two distinct dysfunction in diabetic mouse mesenteric artery contraction are caused by changes in the RhoA-rho kinase signaling pathway. Eur J Pharmacol 683:217\u2013225. doi:\n                    10.1016\/j.ejphar.2012.03.022","journal-title":"Eur J Pharmacol"},{"key":"1396_CR39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejphar.2011.12.036","volume":"678","author":"L Pernomian","year":"2012","unstructured":"Pernomian L, Santos Gomes M, Baraldi Araujo Restini C, Naira Zambelli Ramalho L, Renato Tirapelli C, Maria de Oliveira A (2012) The role of reactive oxygen species in the modulation of the contraction induced by angiotensin II in carotid artery from diabetic rat. Eur J Pharmacol 678:15\u201325. doi:\n                    10.1016\/j.ejphar.2011.12.036","journal-title":"Eur J Pharmacol"},{"key":"1396_CR40","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s001250051140","volume":"42","author":"GM Pieper","year":"1999","unstructured":"Pieper GM (1999) Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 42:204\u2013213. doi:\n                    10.1007\/s001250051140","journal-title":"Diabetologia"},{"key":"1396_CR41","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1111\/j.1476-5381.2010.00955.x","volume":"161","author":"JF Pinho","year":"2010","unstructured":"Pinho JF, Medeiros MA, Capettini LS, Rezende BA, Campos PP, Andrade SP, Cortes SF, Cruz JS, Lemos VS (2010) Phosphatidylinositol 3-kinase-\u03b4 up-regulates L-type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes. Br J Pharmacol 161:1458\u20131471. doi:\n                    10.1111\/j.1476-5381.2010.00955.x","journal-title":"Br J Pharmacol"},{"key":"1396_CR42","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1161\/01.RES.0000196564.18314.23","volume":"97","author":"Y Rikitake","year":"2005","unstructured":"Rikitake Y, Liao JK (2005) Rho GTPases, statins, and nitric oxide. Circ Res 97:1232\u20131235. doi:\n                    10.1161\/01.RES.0000196564.18314.23","journal-title":"Circ Res"},{"key":"1396_CR43","first-page":"762","volume":"257","author":"D Sarubbi","year":"1989","unstructured":"Sarubbi D, McGiff JC, Quilley J (1989) Renal vascular responses and eicosanoid release in diabetic rats. Am J Phys 257:762\u2013768","journal-title":"Am J Phys"},{"key":"1396_CR44","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.2337\/diacare.26.7.2165","volume":"26","author":"MT Schram","year":"2003","unstructured":"Schram MT, Chaturvedi C, Schalkwijk C, Giorgino F, Ebeling P, Fuller JH, Stehouwer CD (2003) Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB prospective complications study. Diabetes Care 26:2165\u20132173. doi:\n                    10.2337\/diacare.26.7.2165","journal-title":"Diabetes Care"},{"key":"1396_CR45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12933-015-0217-0","volume":"14","author":"T Sonobe","year":"2015","unstructured":"Sonobe T, Tsuchimochi H, Schwenke DO, Pearson JT, Shirai M (2015) Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography. Cardiovasc Diabetol 14:51. doi:\n                    10.1186\/s12933-015-0217-0","journal-title":"Cardiovasc Diabetol"},{"key":"1396_CR46","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s00424-010-0786-4","volume":"459","author":"EH Tang","year":"2010","unstructured":"Tang EH, Vanhoutte PM (2010) Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch 459:995\u20131004. doi:\n                    10.1007\/s00424-010-0786-4","journal-title":"Pflugers Arch"},{"key":"1396_CR47","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.phrs.2005.11.002","volume":"53","author":"B Viswanad","year":"2006","unstructured":"Viswanad B, Srinivasan K, Kaul CL, Ramarao P (2006) Effect of tempol on altered angiotensin II and acetylcholine-mediated vascular responses in thoracic aorta isolated from rats with insulin resistance. Pharmacol Res 53:209\u2013215. doi:\n                    10.1016\/j.phrs.2005.11.002","journal-title":"Pharmacol Res"},{"key":"1396_CR48","doi-asserted-by":"publisher","first-page":"8628","DOI":"10.1074\/jbc.M109.057711","volume":"285","author":"Z Xie","year":"2010","unstructured":"Xie Z, Gong MC, Su W, Xie D, Turk J, Guo Z (2010) Role of calcium-independent phospholipase A2\u03b2 in high glucose-induced activation of RhoA, rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals. J Biol Chem 285:8628\u20138638. doi:\n                    10.1074\/jbc.M109.057711","journal-title":"J Biol Chem"},{"key":"1396_CR49","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/cvr\/cvs371","volume":"97","author":"L Yao","year":"2013","unstructured":"Yao L, Chandra S, Toque HA, Bhatta A, Rojas M, Caldwell RB, Caldwell RW (2013) Prevention of diabetes-induced arginase activation and vascular dysfunction by rho kinase (ROCK) knockout. Cardiovasc Res 97:509\u2013519. doi:\n                    10.1093\/cvr\/cvs371","journal-title":"Cardiovasc Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-017-1396-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-017-1396-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-017-1396-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T08:56:30Z","timestamp":1589619390000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-017-1396-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["1396"],"URL":"https:\/\/doi.org\/10.1007\/s00210-017-1396-x","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,27]]},"assertion":[{"value":"21 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}