{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:58:29Z","timestamp":1775296709220,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"JSPS KAKENHI","award":["15K08673"],"award-info":[{"award-number":["15K08673"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00210-018-01596-w","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T11:54:53Z","timestamp":1544010893000},"page":"359-369","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition by general anesthetic propofol of compound action potentials in the frog sciatic nerve and its chemical structure"],"prefix":"10.1007","volume":"392","author":[{"given":"Nobuya","family":"Magori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsugumi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Kumamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"1596_CR1","first-page":"565","volume-title":"Goodman & Gilman\u2019s the pharmacological basis of therapeutics","author":"WA Catterall","year":"2011","unstructured":"Catterall WA, Mackie K (2011) Local anesthetics. In: Brunton LL, Chabner BA, Knollmann BC (eds) Goodman & Gilman\u2019s the pharmacological basis of therapeutics, 12th edn. McGraw-Hill, Medical Publishing Division, New York, USA, pp 565\u2013582","edition":"12"},{"key":"1596_CR2","unstructured":"ChemIDplus (2017) Bethesda, MD: National Library of medicine (US); [update daily; accessed 2017 October 18]. Available at: https:\/\/chem.nlm.nih.gov\/chemidplus\/"},{"key":"1596_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1213\/01.ane.0000287653.77372.d9","volume":"106","author":"SS Cheng","year":"2008","unstructured":"Cheng SS, Yeh J, Flood P (2008) Anesthesia matters: patients anesthetized with propofol have less postoperative pain than those anesthetized with isoflurane. Anesth Analg 106:264\u2013269","journal-title":"Anesth Analg"},{"key":"1596_CR4","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1248\/yakushi.129.485","volume":"129","author":"N Dalkilic","year":"2009","unstructured":"Dalkilic N, Tuncer S, Bariskaner H, Kiziltan E (2009) The effect of tramadol on the rat sciatic nerve conduction: a numerical analysis and conduction velocity distribution study. Yakugaku Zasshi 129:485\u2013493","journal-title":"Yakugaku Zasshi"},{"key":"1596_CR5","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1213\/00000539-198611000-00016","volume":"65","author":"VA Doze","year":"1986","unstructured":"Doze VA, Westphal LM, White PF (1986) Comparison of propofol with methohexital for outpatient anesthesia. Anesth Analg 65:1189\u20131195","journal-title":"Anesth Analg"},{"key":"1596_CR6","volume-title":"Pain, McGraw-Hill","author":"HL Fields","year":"1987","unstructured":"Fields HL (1987) Pain, McGraw-Hill. USA, New York"},{"key":"1596_CR7","doi-asserted-by":"publisher","first-page":"34781","DOI":"10.1074\/jbc.M110.143958","volume":"285","author":"MJM Fischer","year":"2010","unstructured":"Fischer MJM, Leffler A, Niedermirtl F, Kistner K, Eberhardt M, Reeh PW, Nau C (2010) The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem 285:34781\u201334792","journal-title":"J Biol Chem"},{"key":"1596_CR8","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/367607a0","volume":"367","author":"NP Franks","year":"1994","unstructured":"Franks NP, Lieb WR (1994) Molecular and cellular mechanisms of general anaesthesia. Nature 367:607\u2013614","journal-title":"Nature"},{"key":"1596_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0922-4106(91)90054-L","volume":"208","author":"C Frenkel","year":"1991","unstructured":"Frenkel C, Urban BW (1991) Human brain sodium channels as one of the molecular target sites for the new intravenous anaesthetic propofol (2,6-diisopropylphenol). Eur J Pharmacol 208:75\u201379","journal-title":"Eur J Pharmacol"},{"key":"1596_CR10","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1007\/s00217-004-0967-5","volume":"219","author":"CM Guedes","year":"2004","unstructured":"Guedes CM, Pinto AB, Moreira RFA, De Maria CAB (2004) Study of the aroma compounds of rose apple (Syzygium jambos Alston) fruit from Brazil. Eur Food Res Technol 219:460\u2013464","journal-title":"Eur Food Res Technol"},{"key":"1596_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1538\/expanim.62.87","volume":"62","author":"SA Gu\u00e9nette","year":"2013","unstructured":"Gu\u00e9nette SA, Giroux M-C, Vachon P (2013) Pain perception and anaesthesia in research frogs. Exp Anim 62:87\u201392","journal-title":"Exp Anim"},{"key":"1596_CR12","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/00207450590520948","volume":"115","author":"M G\u00fcven","year":"2005","unstructured":"G\u00fcven M, Mert T, G\u00fcnay I (2005) Effects of tramadol on nerve action potentials in rat: comparisons with benzocaine and lidocaine. Int J Neurosci 115:339\u2013349","journal-title":"Int J Neurosci"},{"key":"1596_CR13","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/j.1476-5381.1991.tb12479.x","volume":"104","author":"TG Hales","year":"1991","unstructured":"Hales TG, Lambert JJ (1991) The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br J Pharmacol 104:619\u2013628","journal-title":"Br J Pharmacol"},{"key":"1596_CR14","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3389\/fnhum.2013.00136","volume":"7","author":"SJ Hanrahan","year":"2013","unstructured":"Hanrahan SJ, Greger B, Parker RA, Ogura T, Obara S, Egan TD, House PA (2013) The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines. Front Hum Neurosci 7:136","journal-title":"Front Hum Neurosci"},{"key":"1596_CR15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ejphar.2017.11.047","volume":"819","author":"R Hirao","year":"2018","unstructured":"Hirao R, Fujita T, Sakai A, Kumamoto E (2018) Compound action potential inhibition produced by various antidepressants in the frog sciatic nerve. Eur J Pharmacol 819:122\u2013128","journal-title":"Eur J Pharmacol"},{"key":"1596_CR16","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/BF01042646","volume":"171","author":"E Honkanen","year":"1980","unstructured":"Honkanen E, Pyysalo T, Hirvi T (1980) The aroma of finnish wild raspberries, Rubus idaeus, L. Z Lebensm Unters Forsch 171:180\u2013182","journal-title":"Z Lebensm Unters Forsch"},{"key":"1596_CR17","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1021\/jm00186a013","volume":"23","author":"R James","year":"1980","unstructured":"James R, Glen JB (1980) Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents. J Med Chem 23:1350\u20131357","journal-title":"J Med Chem"},{"key":"1596_CR18","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1124\/jpet.106.111542","volume":"320","author":"PJ Jones","year":"2007","unstructured":"Jones PJ, Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK (2007) Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. J Pharmacol Exp Ther 320:828\u2013836","journal-title":"J Pharmacol Exp Ther"},{"key":"1596_CR19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/sj.bjp.0706868","volume":"149","author":"R Katsuki","year":"2006","unstructured":"Katsuki R, Fujita T, Koga A, Liu T, Nakatsuka T, Nakashima M, Kumamoto E (2006) Tramadol, but not its major metabolite (mono-O-demethyl tramadol) depresses compound action potentials in frog sciatic nerves. Br J Pharmacol 149:319\u2013327","journal-title":"Br J Pharmacol"},{"key":"1596_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.lfs.2013.01.012","volume":"92","author":"H Kawasaki","year":"2013","unstructured":"Kawasaki H, Mizuta K, Fujita T, Kumamoto E (2013) Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves. Life Sci 92:359\u2013367","journal-title":"Life Sci"},{"key":"1596_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0304-3940(93)90568-6","volume":"162","author":"J Kobayashi","year":"1993","unstructured":"Kobayashi J, Ohta M, Terada Y (1993) C fiber generates a slow Na+ spike in the frog sciatic nerve. Neurosci Lett 162:93\u201396","journal-title":"Neurosci Lett"},{"key":"1596_CR22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1272\/jnms.84.165","volume":"84","author":"M Kobayashi","year":"2017","unstructured":"Kobayashi M, Oi Y (2017) Actions of propofol on neurons in the cerebral cortex. J Nippon Med Sch 84:165\u2013169","journal-title":"J Nippon Med Sch"},{"key":"1596_CR23","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1111\/j.1476-5381.2010.00833.x","volume":"160","author":"T Kosugi","year":"2010","unstructured":"Kosugi T, Mizuta K, Fujita T, Nakashima M, Kumamoto E (2010) High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without \u03b12 adrenoceptor activation. Br J Pharmacol 160:1662\u20131676","journal-title":"Br J Pharmacol"},{"key":"1596_CR24","first-page":"89","volume-title":"Frogs: biology, ecology and uses","author":"E Kumamoto","year":"2012","unstructured":"Kumamoto E, Mizuta K, Fujita T (2012) Peripheral nervous system in the frog as a tool to examine the regulation of the transmission of neuronal information. In: Murray JL (ed) Frogs: biology, ecology and uses. Nova Science Publishers, Inc., New York, pp 89\u2013106"},{"key":"1596_CR25","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1152\/jn.1996.75.6.2294","volume":"75","author":"E Kumamoto","year":"1996","unstructured":"Kumamoto E, Murata Y (1996) Enhancement by lanthanide of general anesthetic-induced GABAA-receptor current in rat septal cholinergic neurons in culture. J Neurophysiol 75:2294\u20132299","journal-title":"J Neurophysiol"},{"key":"1596_CR26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.17245\/jdapm.2016.16.4.237","volume":"16","author":"H-S Lee","year":"2016","unstructured":"Lee H-S (2016) Recent advances in topical anesthesia. J Dent Anesth Pain Med 16:237\u2013244","journal-title":"J Dent Anesth Pain Med"},{"key":"1596_CR27","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.ejphar.2017.12.014","volume":"819","author":"N Magori","year":"2018","unstructured":"Magori N, Fujita T, Kumamoto E (2018) Hinokitiol inhibits compound action potentials in the frog sciatic nerve. Eur J Pharmacol 819:254\u2013260","journal-title":"Eur J Pharmacol"},{"key":"1596_CR28","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/j.1528-1167.2005.34904.x","volume":"46","author":"G Martella","year":"2005","unstructured":"Martella G, De Persis C, Bonsi P, Natoli S, Cuomo D, Bernardi G, Calabresi P, Pisani A (2005) Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity. Epilepsia 46:624\u2013635","journal-title":"Epilepsia"},{"key":"1596_CR29","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.lfs.2008.06.002","volume":"83","author":"K Mizuta","year":"2008","unstructured":"Mizuta K, Fujita T, Nakatsuka T, Kumamoto E (2008) Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures. Life Sci 83:198\u2013207","journal-title":"Life Sci"},{"key":"1596_CR30","first-page":"145","volume":"10","author":"K Mizuta","year":"2017","unstructured":"Mizuta K, Fujita T, Yamagata H, Kumamoto E (2017) Bisphenol A inhibits compound action potentials in the frog sciatic nerve in a manner independent of estrogen receptors. Biochem Biophys Rep 10:145\u2013151","journal-title":"Biochem Biophys Rep"},{"key":"1596_CR31","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0022-3565(24)36907-1","volume":"283","author":"R Nadeson","year":"1997","unstructured":"Nadeson R, Goodchild CS (1997) Antinociceptive properties of propofol: involvement of spinal cord \u03b3-aminobutyric acidA receptors. J Pharmacol Exp Ther 283:1181\u20131186","journal-title":"J Pharmacol Exp Ther"},{"key":"1596_CR32","doi-asserted-by":"publisher","first-page":"e00127","DOI":"10.1002\/prp2.127","volume":"3","author":"S Ohtsubo","year":"2015","unstructured":"Ohtsubo S, Fujita T, Matsushita A, Kumamoto E (2015) Inhibition of the compound action potentials of frog sciatic nerves by aroma oil compounds having various chemical structures. Pharmcol Res Perspect 3:e00127","journal-title":"Pharmcol Res Perspect"},{"key":"1596_CR33","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1111\/j.1476-5381.1995.tb16660.x","volume":"116","author":"BA Orser","year":"1995","unstructured":"Orser BA, Bertlik M, Wang L-Y, MacDonald JF (1995) Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. Br J Pharmacol 116:1761\u20131768","journal-title":"Br J Pharmacol"},{"key":"1596_CR34","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/00000542-199702000-00018","volume":"86","author":"L Ratnakumari","year":"1997","unstructured":"Ratnakumari L, Hemmings HC Jr (1997) Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes. Anesthesiology 86:428\u2013439","journal-title":"Anesthesiology"},{"key":"1596_CR35","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/00000542-199908000-00026","volume":"91","author":"B Rehberg","year":"1999","unstructured":"Rehberg B, Duch DS (1999) Suppression of central nervous system sodium channels by propofol. Anesthesiology 91:512\u2013520","journal-title":"Anesthesiology"},{"key":"1596_CR36","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/00000542-198809000-00011","volume":"69","author":"A Shafer","year":"1988","unstructured":"Shafer A, Doze VA, Shafer SL, White PF (1988) Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. Anesthesiology 69:348\u2013356","journal-title":"Anesthesiology"},{"key":"1596_CR37","first-page":"1859","volume":"18","author":"Q-Q Shi","year":"2014","unstructured":"Shi Q-Q, Sun X, Fang H (2014) A mechanism study on propofol\u2019s action on middle latency auditory evoked potential by neurons in ventral partition of medial geniculate body in rats. Eur Rev Med Pharmacol Sci 18:1859\u20131868","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1596_CR38","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1213\/00000539-199706000-00031","volume":"84","author":"M-H Shyr","year":"1997","unstructured":"Shyr M-H, Tsai TH, Yang C-H, Chen H-M, Ng H-F, Tan PPC (1997) Propofol anesthesia increases dopamine and serotonin activities at the somatosensory cortex in rats: a microdialysis study. Anesth Analg 84:1344\u20131348","journal-title":"Anesth Analg"},{"key":"1596_CR39","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ejphar.2010.10.072","volume":"653","author":"C-Y Song","year":"2011","unstructured":"Song C-Y, Xi H-J, Yang L, Qu L-H, Yue Z-Y, Zhou J, Cui X-G, Gao W, Wang N, Pan Z-W, Li W-Z (2011) Propofol inhibited the delayed rectifier potassium current (Ik) via activation of protein kinase C epsilon in rat parietal cortical neurons. Eur J Pharmacol 653:16\u201320","journal-title":"Eur J Pharmacol"},{"key":"1596_CR40","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.brainres.2005.02.048","volume":"1043","author":"Y-Y Sun","year":"2005","unstructured":"Sun Y-Y, Li K-C, Chen J (2005) Evidence for peripherally antinociceptive action of propofol in rats: behavioral and spinal neuronal responses to subcutaneous bee venom. Brain Res 1043:231\u2013235","journal-title":"Brain Res"},{"key":"1596_CR41","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.biopha.2018.04.041","volume":"103","author":"R Suzuki","year":"2018","unstructured":"Suzuki R, Fujita T, Mizuta K, Kumamoto E (2018) Inhibition by non-steroidal anti-inflammatory drugs of compound action potentials in frog sciatic nerve fibers. Biomed Pharmacother 103:326\u2013335","journal-title":"Biomed Pharmacother"},{"key":"1596_CR42","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1213\/ANE.0b013e31827f560d","volume":"116","author":"K Takechi","year":"2013","unstructured":"Takechi K, Carstens MI, Klein AH, Carstens E (2013) The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat. Anesth Analg 116:932\u2013938","journal-title":"Anesth Analg"},{"key":"1596_CR43","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/reg2.80","volume":"4","author":"MM Thygesen","year":"2017","unstructured":"Thygesen MM, Rasmussen MM, Madsen JG, Pedersen M, Lauridsen H (2017) Propofol (2, 6-diisopropylphenol) is an applicable immersion anesthetic in the axolotl with potential uses in hemodynamic and neurophysiological experiments. Regeneration 4:124\u2013131","journal-title":"Regeneration"},{"key":"1596_CR44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.brainres.2003.10.024","volume":"996","author":"HA Tokuno","year":"2004","unstructured":"Tokuno HA, Bradberry CW, Everill B, Agulian SK, Wilkes S, Baldwin RM, Tamagnan GD, Kocsis JD (2004) Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves. Brain Re 996:159\u2013167","journal-title":"Brain Re"},{"key":"1596_CR45","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.lfs.2013.01.011","volume":"92","author":"D Tomohiro","year":"2013","unstructured":"Tomohiro D, Mizuta K, Fujita T, Nishikubo Y, Kumamoto E (2013) Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. Life Sci 92:368\u2013378","journal-title":"Life Sci"},{"key":"1596_CR46","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0304-3940(01)02185-1","volume":"312","author":"S Tsutsumi","year":"2001","unstructured":"Tsutsumi S, Tomioka A, Sudo M, Nakamura A, Shirakura K, Takagishi K, Kohama K (2001) Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells. Neurosci Lett 312:45\u201349","journal-title":"Neurosci Lett"},{"key":"1596_CR47","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/540238","volume":"2014","author":"Y Uemura","year":"2014","unstructured":"Uemura Y, Fujita T, Ohtsubo S, Hirakawa N, Sakaguchi Y, Kumamoto E (2014) Effects of various antiepileptics used to alleviate neuropathic pain on compound action potential in frog sciatic nerves: comparison with those of local anesthetics. Biomed Res Int 2014:540238","journal-title":"Biomed Res Int"},{"key":"1596_CR48","first-page":"19","volume":"14","author":"JW Vanable","year":"1985","unstructured":"Vanable JW (1985) Benzocaine: an excellent amphibian anesthetic. Axolotl Newsletter 14:19\u201321","journal-title":"Axolotl Newsletter"},{"key":"1596_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2009.01.007","volume":"605","author":"I Vasileiou","year":"2009","unstructured":"Vasileiou I, Xanthos T, Koudouna E, Perrea D, Klonaris C, Katsargyris A, Papadimitriou L (2009) Propofol: a review of its non-anaesthetic effects. Eur J Pharmacol 605:1\u20138","journal-title":"Eur J Pharmacol"},{"key":"1596_CR50","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0014-2999(92)90147-V","volume":"218","author":"F Veintemilla","year":"1992","unstructured":"Veintemilla F, Elinder F, \u00c5rhem P (1992) Mechanisms of propofol action on ion currents in the myelinated axon of Xenopus laevis. Eur J Pharmacol 218:59\u201368","journal-title":"Eur J Pharmacol"},{"key":"1596_CR51","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.brainres.2015.11.030","volume":"1631","author":"M Wakita","year":"2016","unstructured":"Wakita M, Kotani N, Akaike N (2016) Effects of propofol on glycinergic neurotransmission in a single spinal nerve synapse preparation. Brain Res 1631:147\u2013156","journal-title":"Brain Res"},{"key":"1596_CR52","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev.pharmtox.41.1.23","volume":"41","author":"T Yamakura","year":"2001","unstructured":"Yamakura T, Bertaccini E, Trudell JR, Harris RA (2001) Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol 41:23\u201351","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1596_CR53","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0304-3940(95)11431-U","volume":"188","author":"T Yamakura","year":"1995","unstructured":"Yamakura T, Sakimura K, Shimoji K, Mishina M (1995) Effects of propofol on various AMPA-, kainate- and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes. Neurosci Lett 188:187\u2013190","journal-title":"Neurosci Lett"},{"key":"1596_CR54","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/AAP.0b013e3182485965","volume":"37","author":"E Yilmaz-Rastoder","year":"2012","unstructured":"Yilmaz-Rastoder E, Gold MS, Hough KA, Gebhart GF, Williams BA (2012) Effect of adjuvant drugs on the action of local anesthetics in isolated rat sciatic nerves. Reg Anesth Pain Med 37:403\u2013409","journal-title":"Reg Anesth Pain Med"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-018-01596-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-018-01596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-018-01596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:20:37Z","timestamp":1775294437000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-018-01596-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["1596"],"URL":"https:\/\/doi.org\/10.1007\/s00210-018-01596-w","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]},"assertion":[{"value":"14 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Animal Care and Use Committee of Saga University, Saga, Japan.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}