{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:34:58Z","timestamp":1770816898105,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","award":["K\/ZDS\/006233"],"award-info":[{"award-number":["K\/ZDS\/006233"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Center in Poland","award":["DEC-2011\/02\/A\/NZ4\/00031"],"award-info":[{"award-number":["DEC-2011\/02\/A\/NZ4\/00031"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00210-018-1516-2","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T01:34:28Z","timestamp":1527212068000},"page":"875-881","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice"],"prefix":"10.1007","volume":"391","author":[{"given":"Magdalena","family":"Kota\u0144ska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil J.","family":"Kuder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Szczepa\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Sapa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kie\u0107-Kononowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"key":"1516_CR1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1124\/jpet.115.222828","volume":"353","author":"K Al-Barazanji","year":"2015","unstructured":"Al-Barazanji K, McNulty J, Binz J, Generaux C, Benson W, Young A, Chen L (2015) Synergistic effects of GPR119 agonist with metformin on weight loss in diet-induced obese mice. J Pharmacol Exp Ther 353:496\u2013504","journal-title":"J Pharmacol Exp Ther"},{"key":"1516_CR2","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/ijo.2008.135","volume":"32","author":"N Barak","year":"2008","unstructured":"Barak N, Greenway FL, Fujioka K, Aronne LJ, Kushner RF (2008) Effect of histaminergic manipulation on weight in obese adults: a randomized placebo controlled trial. Int J Obes 32:1559\u20131565","journal-title":"Int J Obes"},{"key":"1516_CR3","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/sj.bjp.0705964","volume":"143","author":"AJ Barbier","year":"2004","unstructured":"Barbier AJ, Berridge C, Dugovic C, Laposky AD, Wilson SJ, Boggs J, Aluisio L, Lord B, Mazur C, Pudiak CM, Langlois X, Xiao W, Apodaca R, Carruthers NI, Lovenberg TW (2004) Acute awake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol 143:649\u2013661","journal-title":"Br J Pharmacol"},{"issue":"10","key":"1516_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141327","volume":"10","author":"M Dudek","year":"2015","unstructured":"Dudek M, Knutelska J, Bednarski M, Nowi\u0144ski L, Zygmunt M, Mordyl B, G\u0142uch-Lutwin M, Kazek G, Sapa J, Pytka K (2015a) A comparison of the anorectic effect and safety of the alpha2-adrenoceptor ligands guanafacine and yohimbine in rats with diet-induced obesity. PLoS One 10(10):e0141327","journal-title":"PLoS One"},{"key":"1516_CR5","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s11011-015-9736-3","volume":"30","author":"M Dudek","year":"2015","unstructured":"Dudek M, Marcinkowska M, Bucki A, Olczyk A, Ko\u0142aczkowski M (2015b) Idalopirdine\u2014a small molecule antagonist of 5-HT6 with therapeutic potential against obesity. Metab Brain Dis 30:1487\u20131494","journal-title":"Metab Brain Dis"},{"key":"1516_CR6","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s11011-016-9840-z","volume":"31","author":"M Dudek","year":"2016","unstructured":"Dudek M, Kuder K, Ko\u0142aczkowski M, Olczyk A, \u017bmudzka E, Rak A, Bednarski M, Pytka K, Sapa J, Kie\u0107-Kononowicz K (2016) H3 histamine receptor antagonist pitolisantpitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis 31:1023\u20131029","journal-title":"Metab Brain Dis"},{"key":"1516_CR7","unstructured":"EMA (2015) \n                    http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Public_assessment_report\/human\/002616\/WC500204749.pdf"},{"key":"1516_CR8","first-page":"289","volume-title":"Presynaptic receptors for dopamine, histamine, and serotonin pharmacology of neurotransmitter release handbook of experimental pharmacology 184","author":"TJ Feuerstein","year":"2008","unstructured":"Feuerstein TJ (2008) Presynaptic receptors for dopamine, histamine, and serotonin pharmacology of neurotransmitter release handbook of experimental pharmacology 184. Springer-Verlag, Berlin Heidelberg, pp 289\u2013338"},{"key":"1516_CR9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1517\/13543784.14.3.223","volume":"14","author":"AA Hancock","year":"2005","unstructured":"Hancock AA, Brune ME (2005) Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists\/inverse agonists. Expert Opinert Opin Investig Drugs 14:223\u2013241","journal-title":"Expert Opinert Opin Investig Drugs"},{"key":"1516_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fnins.2017.00050","volume":"11","author":"M Kota\u0144ska","year":"2017","unstructured":"Kota\u0144ska M, \u015aniecikowska J, Jastrz\u0119bska-Wiesek M, Ko\u0142aczkowski M, Pytka K (2017) Metabolic and cardiovascular benefits and risks of EMD386088-A 5-HT6 receptor partial agonist and dopamine transporter inhibitor. Front Neurosci 11:50","journal-title":"Front Neurosci"},{"issue":"8","key":"1516_CR11","doi-asserted-by":"publisher","first-page":"e104160","DOI":"10.1371\/journal.pone.0104160","volume":"9","author":"J Lian","year":"2014","unstructured":"Lian J, Huang X-F, Pai N, Deng C (2014) Preventing olanzapine-induced weight gain using betahistine: a study in a rat model with chronic olanzapine treatment. PlosOne 9(8):e104160","journal-title":"PlosOne"},{"key":"1516_CR12","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1038\/sj.ijo.0803036","volume":"29","author":"K Malml\u00f6f","year":"2005","unstructured":"Malml\u00f6f K, Zaragoza F, Golozoubova V, Refsgaard HH, Cremers T, Raun K, Wulff S, Jahansen PB, Westerink B, Rimvall K (2005) Influence of selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight. Int J Obes 29:1402\u20131412","journal-title":"Int J Obes"},{"key":"1516_CR13","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1038\/oby.2006.252","volume":"14","author":"K Malml\u00f6f","year":"2006","unstructured":"Malml\u00f6f K, Golozoubova V, Peschke B, Wulff BS, Resfsgaard HHF, Johansen PB, Cremers T, Rimvall K (2006) Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. Obesity 14:2154\u20132162","journal-title":"Obesity"},{"key":"1516_CR14","doi-asserted-by":"crossref","unstructured":"Meier G, Apelt J, Reichert U, Gra\u00dfmann S, Ligneau X, Elz S, Leurquin F, Ganellin CR, Schwartz J-Ch, Schunack W, Stark H (2001). Influence of imidazole replacement in different structural classes of histamine H3-receptor antagonists. Eur J Pharm Sci 13(3); 249-259","DOI":"10.1016\/S0928-0987(01)00106-3"},{"key":"1516_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pbb.2017.10.013","volume":"163","author":"CF Moore","year":"2017","unstructured":"Moore CF, Schalen GS, Mancino S, Sabino V, Cottone P (2017) A behavioral and pharmacological characterizations of palatable diet alternation in mice. Pharmacol Biochem Behav 163:1\u20138","journal-title":"Pharmacol Biochem Behav"},{"key":"1516_CR16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/bph.12429","volume":"171","author":"T Nakamura","year":"2014","unstructured":"Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K (2014) The expression and function of histamine H3 receptors in pancreatic beta cells. Br J Pharmacol 171:171\u2013185","journal-title":"Br J Pharmacol"},{"key":"1516_CR17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1124\/jpet.110.171306","volume":"336","author":"MB Passani","year":"2011","unstructured":"Passani MB, Blandina P, Torrealba F (2011) The histamine H3 receptor and eating behavior. J Pharmacol Exp Therap 336:24\u201329","journal-title":"J Pharmacol Exp Therap"},{"key":"1516_CR18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neuropharm.2015.07.002","volume":"106","author":"G Provensi","year":"2016","unstructured":"Provensi G, Blandina P, Passani MB (2016) The histaminergic system as a target for the prevention of obesity and metabolic syndrome. Neuropharmacol 106:3\u201312","journal-title":"Neuropharmacol"},{"key":"1516_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejphar.2011.01.015","volume":"655","author":"A Tahara","year":"2011","unstructured":"Tahara A, Matsuyama-Yokono A, Shibasaki M (2011) Effects of antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice. Eur J Phamacol 655:108\u2013116","journal-title":"Eur J Phamacol"},{"key":"1516_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/bph.12149","volume":"169","author":"M Uguen","year":"2013","unstructured":"Uguen M, Perrin D, Belliard S, Ligneau X, Beardsley PM, Lecomte JM, Schwartz JC (2013) Preclinical evaluation of the abuse potential of pitolisant, a histamine H3 receptor inverse agonisr\/antagonist compared with modafinil. Br J Pharmacol 169:632\u2013644","journal-title":"Br J Pharmacol"},{"key":"1516_CR21","doi-asserted-by":"publisher","first-page":"461","DOI":"10.2741\/s279","volume":"S4","author":"J Walter","year":"2012","unstructured":"Walter J, Stark H (2012) Histamine receptor subtypes: a century of national drug design. Front Biosci S4:461\u2013488","journal-title":"Front Biosci"},{"key":"1516_CR22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.2353\/ajpath.2010.091198","volume":"177","author":"K-Y Wang","year":"2010","unstructured":"Wang K-Y, Tanimoto A, Yamada S, Guo X, Ding Y, Watanabe T, Watanabe T, Kohno K, Hirano K-I, Tsukada H, Sasaguri Y (2010) Histamine regulation in glucose and lipid metabolism via histamine receptors. Am J Pathol 177:713\u2013722","journal-title":"Am J Pathol"},{"key":"1516_CR23","unstructured":"Yates SL, Tedford CE, Brunden KR (2002) The use of histamine H3 receptor inverse agonists for the control of appetite and treatment of obesity 2002. Gliatech, Inc.: WO2002015905A1"},{"key":"1516_CR24","doi-asserted-by":"publisher","first-page":"13866","DOI":"10.1073\/pnas.0506104103","volume":"103","author":"R Yoshimoto","year":"2006","unstructured":"Yoshimoto R, Miyamoto Y, Shimamura K, Ishihara A, Takahashi K, Kotani H, Chen AS, Chen HY, MacNeil DJ, Kanatani A, Tokita S (2006) Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. PNAS 103:13866\u201313871","journal-title":"PNAS"},{"key":"1516_CR25","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1007\/s00011-012-0528-5","volume":"61","author":"DD Zhang","year":"2012","unstructured":"Zhang DD, Sisignano M, Schuh CD, Sander K, Stark H, Scholich K (2012) Overdose of the histamine H3 inverse agonist pitolisant increases thermal pain thresholds. Inflam Res 61:1283\u20131291","journal-title":"Inflam Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-018-1516-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-018-1516-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-018-1516-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T19:05:34Z","timestamp":1558724734000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-018-1516-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,25]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["1516"],"URL":"https:\/\/doi.org\/10.1007\/s00210-018-1516-2","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,25]]},"assertion":[{"value":"12 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}