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This article does not contain any studies with human participants performed by any of the authors. All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals by the National Institutes of Health (USA) and approved by the Research Ethics Committee of Sun Yat-sen University (No. 017962).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}