{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T01:24:17Z","timestamp":1775525057107,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002717","name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","award":["CNEPRU F00220130061"],"award-info":[{"award-number":["CNEPRU F00220130061"]}],"id":[{"id":"10.13039\/501100002717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00210-018-1592-3","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T20:28:21Z","timestamp":1543350501000},"page":"299-311","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Gadolinium chloride attenuates acetic acid-evoked colitis in mice by reducing neutrophil infiltration and pro-oxidative enzyme activity"],"prefix":"10.1007","volume":"392","author":[{"given":"Meriem","family":"Ferrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-6415","authenticated-orcid":false,"given":"Hichem","family":"Moulahoum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belkacem Mohamed Amine","family":"Boumaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souad","family":"Mouzaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"P\u00e9rianin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahia","family":"Djerdjouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"1592_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1527-3466.2001.tb00182.x","volume":"19","author":"LC Adding","year":"2006","unstructured":"Adding LC, Bannenberg GL, Gustafsson LE (2006) Basic experimental studies and clinical aspects of gadolinium salts and chelates. Cardiovasc Drug Rev 19:41\u201356. https:\/\/doi.org\/10.1111\/j.1527-3466.2001.tb00182.x","journal-title":"Cardiovasc Drug Rev"},{"key":"1592_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ejphar.2012.06.014","volume":"691","author":"I Amrouche-Mekkioui","year":"2012","unstructured":"Amrouche-Mekkioui I, Djerdjouri B (2012) N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice. Eur J Pharmacol 691:209\u2013217. https:\/\/doi.org\/10.1016\/j.ejphar.2012.06.014","journal-title":"Eur J Pharmacol"},{"key":"1592_CR3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.coi.2003.12.001","volume":"16","author":"BM Babior","year":"2004","unstructured":"Babior BM (2004) NADPH oxidase. Curr Opin Immunol 16:42\u201347. https:\/\/doi.org\/10.1016\/j.coi.2003.12.001","journal-title":"Curr Opin Immunol"},{"key":"1592_CR4","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.it.2007.06.002","volume":"28","author":"N Borregaard","year":"2007","unstructured":"Borregaard N, S\u00f8rensen OE, Theilgaard-M\u00f6nch K (2007) Neutrophil granules: a library of innate immunity proteins. Trends Immunol 28:340\u2013345. https:\/\/doi.org\/10.1016\/j.it.2007.06.002","journal-title":"Trends Immunol"},{"key":"1592_CR5","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/0003-2697(72)90335-1","volume":"46","author":"AF Boyne","year":"1972","unstructured":"Boyne AF, Ellman GL (1972) A methodology for analysis of tissue sulfhydryl components. Anal Biochem 46:639\u2013653. https:\/\/doi.org\/10.1016\/0003-2697(72)90335-1","journal-title":"Anal Biochem"},{"key":"1592_CR6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/abio.1976.9999","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1006\/abio.1976.9999","journal-title":"Anal Biochem"},{"key":"1592_CR7","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1097\/mib.0b013e318281f54e","volume":"19","author":"JC Brazil","year":"2013","unstructured":"Brazil JC, Louis NA, Parkos CA (2013) The role of polymorphonuclear leukocyte trafficking in the perpetuation of inflammation during inflammatory bowel disease. Inflamm Bowel Dis 19:1556\u20131565. https:\/\/doi.org\/10.1097\/mib.0b013e318281f54e","journal-title":"Inflamm Bowel Dis"},{"key":"1592_CR8","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V (2004) Neutrophil extracellular traps kill bacteria. Science 303:1532\u20131535. https:\/\/doi.org\/10.1126\/science.1092385","journal-title":"Science"},{"key":"1592_CR9","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.vetimm.2011.12.006","volume":"145","author":"I Conejeros","year":"2012","unstructured":"Conejeros I, Vel\u00e1squez ZD, Carretta MD, Alarc\u00f3n P, Hidalgo MA, Burgos RA (2012) 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. Vet Immunol Immunopathol 145:540\u2013545. https:\/\/doi.org\/10.1016\/j.vetimm.2011.12.006","journal-title":"Vet Immunol Immunopathol"},{"key":"1592_CR10","doi-asserted-by":"publisher","unstructured":"Dewald B, Baggiolini M (1986) [12] Methods for assessing exocytosis by neutrophil leukocytes. Elsevier. https:\/\/doi.org\/10.1016\/s0076-6879(86)32014-7","DOI":"10.1016\/s0076-6879(86)32014-7"},{"key":"1592_CR11","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1182\/blood.v97.2.339","volume":"97","author":"E Carlo Di","year":"2001","unstructured":"Di Carlo E (2001) The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood 97:339\u2013345. https:\/\/doi.org\/10.1182\/blood.v97.2.339","journal-title":"Blood"},{"key":"1592_CR12","doi-asserted-by":"publisher","unstructured":"Du C, Wang P, Yu Y, Chen F, Liu J, Li Y (2014) Gadolinium chloride improves the course of TNBS and DSS-induced colitis through protecting against colonic mucosal inflammation Sci Rep 4 https:\/\/doi.org\/10.1038\/srep06096","DOI":"10.1038\/srep06096"},{"key":"1592_CR13","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/0016-5085(95)90599-5","volume":"109","author":"CO Elson","year":"1995","unstructured":"Elson CO, Sartor RB, Tennyson GS, Riddell RH (1995) Experimental models of inflammatory bowel disease. Gastroenterology 109:1344\u20131367. https:\/\/doi.org\/10.1016\/0016-5085(95)90599-5","journal-title":"Gastroenterology"},{"key":"1592_CR14","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/0016-5085(92)70017-6","volume":"102","author":"RN Fedorak","year":"1992","unstructured":"Fedorak RN, Empey LR, Walker K (1992) Verapamil alters eicosanoid synthesis and accelerates healing during experimental colitis in rats. Gastroenterology 102:1229\u20131235. https:\/\/doi.org\/10.1016\/0016-5085(92)70017-6","journal-title":"Gastroenterology"},{"key":"1592_CR15","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.4049\/jimmunol.177.6.3507","volume":"177","author":"L Franchi","year":"2006","unstructured":"Franchi L, McDonald C, Kanneganti TD, Amer A, Nunez G (2006) Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense. J Immunol 177:3507\u20133513. https:\/\/doi.org\/10.4049\/jimmunol.177.6.3507","journal-title":"J Immunol"},{"key":"1592_CR16","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1097\/rli.0b013e3181852171","volume":"43","author":"T Frenzel","year":"2008","unstructured":"Frenzel T, Lengsfeld P, Schirmer H, H\u00fctter J, Weinmann H-J (2008) Stability of gadolinium-based magnetic resonance imaging contrast agents in human serum at 37\u00b0C. Investig Radiol 43:817\u2013828. https:\/\/doi.org\/10.1097\/rli.0b013e3181852171","journal-title":"Investig Radiol"},{"key":"1592_CR17","doi-asserted-by":"publisher","first-page":"659","DOI":"10.2353\/ajpath.2006.050599","volume":"168","author":"MG Frid","year":"2006","unstructured":"Frid MG, Brunetti JA, Burke DL, Carpenter TC, Davie NJ, Reeves JT, Roedersheimer MT, van Rooijen N, Stenmark KR (2006) Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte\/macrophage lineage. Am J Pathol 168:659\u2013669. https:\/\/doi.org\/10.2353\/ajpath.2006.050599","journal-title":"Am J Pathol"},{"key":"1592_CR18","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s00595-005-3162-9","volume":"36","author":"D Giakoustidis","year":"2006","unstructured":"Giakoustidis D, Papageorgiou G, Iliadis S, Giakoustidis A, Kostopoulou E, Kontos N, Botsoglou E, Tsantilas D, Papanikolaou V, Takoudas D (2006) The protective effect of \u03b1-tocopherol and GdCl3 against hepatic ischemia\/reperfusion injury. Surg Today 36:450\u2013456. https:\/\/doi.org\/10.1007\/s00595-005-3162-9","journal-title":"Surg Today"},{"key":"1592_CR19","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/s1091-255x(98)80033-4","volume":"2","author":"B Gloor","year":"1998","unstructured":"Gloor B (1998) Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice. J Gastrointest Surg 2:430\u2013435. https:\/\/doi.org\/10.1016\/s1091-255x(98)80033-4","journal-title":"J Gastrointest Surg"},{"key":"1592_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-m","volume":"196","author":"L G\u00f3th","year":"1991","unstructured":"G\u00f3th L (1991) A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 196:143\u2013151. https:\/\/doi.org\/10.1016\/0009-8981(91)90067-m","journal-title":"Clin Chim Acta"},{"key":"1592_CR21","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/jlb.52.3.296","volume":"52","author":"MJ Hardonk","year":"1992","unstructured":"Hardonk MJ, Dijkhuis FWJ, Hulstaert CE, Koudstaal J (1992) Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukoc Biol 52:296\u2013302. https:\/\/doi.org\/10.1002\/jlb.52.3.296","journal-title":"J Leukoc Biol"},{"key":"1592_CR22","doi-asserted-by":"publisher","first-page":"784","DOI":"10.2353\/ajpath.2006.060010","volume":"169","author":"F Hildebrand","year":"2006","unstructured":"Hildebrand F, Hubbard WJ, Choudhry MA, Frink M, Pape H-C, Kunkel SL, Chaudry IH (2006) Kupffer cells and their mediators. Am J Pathol 169:784\u2013794. https:\/\/doi.org\/10.2353\/ajpath.2006.060010","journal-title":"Am J Pathol"},{"key":"1592_CR23","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/meg.0b013e3282f246c2","volume":"20","author":"PM Irving","year":"2008","unstructured":"Irving PM, Macey MG, Feakins RM, Knowles CH, Frye JN, Liyanage SH, Dorudi S, Williams NS, Rampton DS (2008) Platelet\u2013leucocyte aggregates form in the mesenteric vasculature in patients with ulcerative colitis. Eur J Gastroenterol Hepatol 20:283\u2013289. https:\/\/doi.org\/10.1097\/meg.0b013e3282f246c2","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1592_CR24","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.transproceed.2006.02.067","volume":"38","author":"C Jahnke","year":"2006","unstructured":"Jahnke C, Mehrabi A, Golling M, Frankenberg M, Kashfi A, Nentwich H, Fonouni H, Nickkholgh A, Schemmer P, Gutt CN, Weitz J, Schmidt J, Gebhard MM, B\u00fcchler MW, Kraus T (2006) Evaluation of microperfusion disturbances in the transplanted liver after Kupffer cell destruction using GdCl3: an experimental porcine study. Transplant Proc 38:1588\u20131595. https:\/\/doi.org\/10.1016\/j.transproceed.2006.02.067","journal-title":"Transplant Proc"},{"key":"1592_CR25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1021\/np010323o","volume":"65","author":"S Johansson","year":"2002","unstructured":"Johansson S, G\u00f6ransson U, Luijendijk T, Backlund A, Claeson P, Bohlin L (2002) A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products. J Nat Prod 65:32\u201341. https:\/\/doi.org\/10.1021\/np010323o","journal-title":"J Nat Prod"},{"key":"1592_CR26","doi-asserted-by":"publisher","unstructured":"K\u00e1llay E, Bajna E, Kriwanek S, Bonner E, Peterlik M, Cross HS (2000) Role of Dietary Calcium in Growth Modulation of Human Colon Cancer Cells. Elsevier. https:\/\/doi.org\/10.1533\/9781845698188.6.324","DOI":"10.1533\/9781845698188.6.324"},{"key":"1592_CR27","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","volume":"28","author":"A Kaser","year":"2010","unstructured":"Kaser A, Zeissig S, Blumberg RS (2010) Inflammatory bowel disease. Annu Rev Immunol 28:573\u2013621. https:\/\/doi.org\/10.1146\/annurev-immunol-030409-101225","journal-title":"Annu Rev Immunol"},{"key":"1592_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nature10209","volume":"474","author":"B Khor","year":"2011","unstructured":"Khor B, Gardet A, Xavier RJ (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474:307\u2013317. https:\/\/doi.org\/10.1038\/nature10209","journal-title":"Nature"},{"key":"1592_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/01.shk.0000144423.40270.96","volume":"23","author":"M Kinoshita","year":"2005","unstructured":"Kinoshita M, Uchida T, Nakashima H, Ono S, Seki S, Hiraide H (2005) Opposite effects of enhanced tumor necrosis factor-alpha production from Kupffer cells by gadolinium chloride on liver injury\/mortality in endotoxemia of normal and partially hepatectomized mice. Shock 23:65\u201372. https:\/\/doi.org\/10.1097\/01.shk.0000144423.40270.96","journal-title":"Shock"},{"key":"1592_CR30","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","volume":"87","author":"JE Krawisz","year":"1984","unstructured":"Krawisz JE, Sharon P, Stenson WF (1984) Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87:1344\u20131350","journal-title":"Gastroenterology"},{"key":"1592_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/path.1409","volume":"201","author":"L Kruidenier","year":"2003","unstructured":"Kruidenier L, Kuiper I, Lamers CBHW, Verspaget HW (2003) Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants. J Pathol 201:28\u201336. https:\/\/doi.org\/10.1002\/path.1409","journal-title":"J Pathol"},{"key":"1592_CR32","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/0003-2697(89)90710-0","volume":"182","author":"W Kueng","year":"1989","unstructured":"Kueng W, Silber E, Eppenberger U (1989) Quantification of cells cultured on 96-well plates. Anal Biochem 182:16\u201319. https:\/\/doi.org\/10.1016\/0003-2697(89)90710-0","journal-title":"Anal Biochem"},{"key":"1592_CR33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.freeradbiomed.2007.03.028","volume":"43","author":"JD Lambeth","year":"2007","unstructured":"Lambeth JD, Kawahara T, Diebold B (2007) Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med 43:319\u2013331. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.03.028","journal-title":"Free Radic Biol Med"},{"key":"1592_CR34","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00441-017-2727-4","volume":"371","author":"T Lisman","year":"2018","unstructured":"Lisman T (2018) Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease. Cell Tissue Res 371:567\u2013576. https:\/\/doi.org\/10.1007\/s00441-017-2727-4","journal-title":"Cell Tissue Res"},{"key":"1592_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of Pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"Eur J Biochem"},{"key":"1592_CR36","doi-asserted-by":"publisher","unstructured":"McGahon AJ et al (1995) Chapter 9. The end of the (cell) line: methods for the study of apoptosis in vitro. Elsevier. https:\/\/doi.org\/10.1016\/s0091-679x(08)61929-9","DOI":"10.1016\/s0091-679x(08)61929-9"},{"key":"1592_CR37","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1182\/blood-2013-11-536755","volume":"123","author":"CGJ McKenzie","year":"2014","unstructured":"McKenzie CGJ, Kim M, Singh TK, Milev Y, Freedman J, Semple JW (2014) Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI). Blood 123:3496\u20133503. https:\/\/doi.org\/10.1182\/blood-2013-11-536755","journal-title":"Blood"},{"key":"1592_CR38","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1006\/niox.2000.0319","volume":"5","author":"KM Miranda","year":"2001","unstructured":"Miranda KM, Espey MG, Wink DA (2001) A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5:62\u201371. https:\/\/doi.org\/10.1006\/niox.2000.0319","journal-title":"Nitric Oxide"},{"key":"1592_CR39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/jlb.59.2.189","volume":"59","author":"JP Mizgerd","year":"1996","unstructured":"Mizgerd JP, Molina RM, Stearns RC, Brain JD, Warner AE (1996) Gadolinium induces macrophage apoptosis. J Leukoc Biol 59:189\u2013195. https:\/\/doi.org\/10.1002\/jlb.59.2.189","journal-title":"J Leukoc Biol"},{"key":"1592_CR40","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jtemb.2018.01.009","volume":"47","author":"H Moulahoum","year":"2018","unstructured":"Moulahoum H, Boumaza BMA, Ferrat M, Nagy AL, Olteanu DE, Bounaama A, Clichici S (2018) Aberrant crypt foci are regionally affected by zinc treatment in a 1,2-dimethylhydrazine induced colon carcinogenesis model. J Trace Elem Med Biol 47:21\u201330. https:\/\/doi.org\/10.1016\/j.jtemb.2018.01.009","journal-title":"J Trace Elem Med Biol"},{"key":"1592_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/312484","volume":"2014","author":"S Mouzaoui","year":"2014","unstructured":"Mouzaoui S, Djerdjouri B, Makhezer N, Kroviarski Y, El-Benna J, Dang PM-C (2014) Tumor necrosis factor-\u03b1-induced colitis increases NADPH oxidase 1 expression, oxidative stress, and neutrophil recruitment in the colon: preventive effect of Apocynin. Mediat Inflamm 2014:1\u201315. https:\/\/doi.org\/10.1155\/2014\/312484","journal-title":"Mediat Inflamm"},{"key":"1592_CR42","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1084\/jem.182.5.1281","volume":"182","author":"MF Neurath","year":"1995","unstructured":"Neurath MF (1995) Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 182:1281\u20131290. https:\/\/doi.org\/10.1084\/jem.182.5.1281","journal-title":"J Exp Med"},{"key":"1592_CR43","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/s0171-2985(11)80294-9","volume":"180","author":"S Oez","year":"1990","unstructured":"Oez S, Welte K, Platzer E, Kalden JR (1990) A simple assay for quantifying the inducible adherence of neutrophils. Immunobiology 180:308\u2013315. https:\/\/doi.org\/10.1016\/s0171-2985(11)80294-9","journal-title":"Immunobiology"},{"key":"1592_CR44","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"1592_CR45","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1620\/tjem.203.267","volume":"203","author":"H Okutan","year":"2004","unstructured":"Okutan H, Savas C, Ozguner IF, Yonden Z, Eren VC, Delibas N (2004) Lung injury after aortic occlusion-reperfusion in rats: the role of gadolinium chloride. Tohoku J Exp Med 203:267\u2013273. https:\/\/doi.org\/10.1620\/tjem.203.267","journal-title":"Tohoku J Exp Med"},{"key":"1592_CR46","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.intimp.2013.06.004","volume":"17","author":"C Page","year":"2013","unstructured":"Page C, Pitchford S (2013) Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation. Int Immunopharmacol 17:1176\u20131184. https:\/\/doi.org\/10.1016\/j.intimp.2013.06.004","journal-title":"Int Immunopharmacol"},{"key":"1592_CR47","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00281-008-0124-5","volume":"30","author":"K Rokutan","year":"2008","unstructured":"Rokutan K, Kawahara T, Kuwano Y, Tominaga K, Nishida K, Teshima-Kondo S (2008) Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol 30:315\u2013327. https:\/\/doi.org\/10.1007\/s00281-008-0124-5","journal-title":"Semin Immunopathol"},{"key":"1592_CR48","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/hep.26109","volume":"57","author":"L Rolas","year":"2013","unstructured":"Rolas L, Makhezer N, Hadjoudj S, el-Benna J, Djerdjouri B, Elkrief L, Moreau R, P\u00e9rianin A (2013) Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis. Hepatology 57:1163\u20131171. https:\/\/doi.org\/10.1002\/hep.26109","journal-title":"Hepatology"},{"key":"1592_CR49","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.smim.2009.10.001","volume":"21","author":"P Rosenstiel","year":"2009","unstructured":"Rosenstiel P, Sina C, Franke A, Schreiber S (2009) Towards a molecular risk map\u2014recent advances on the etiology of inflammatory bowel disease. Semin Immunol 21:334\u2013345. https:\/\/doi.org\/10.1016\/j.smim.2009.10.001","journal-title":"Semin Immunol"},{"key":"1592_CR50","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1189\/jlb.71.3.410","volume":"71","author":"BH Segal","year":"2002","unstructured":"Segal BH, Kuhns DB, Ding L, Gallin JI, Holland SM (2002) Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. J Leukoc Biol 71:410\u2013416","journal-title":"J Leukoc Biol"},{"key":"1592_CR51","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/carcin\/23.6.993","volume":"23","author":"DN Seril","year":"2002","unstructured":"Seril DN, Liao J, Ho K-LK, Yang CS, Yang G-Y (2002) Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine. Carcinogenesis 23:993\u20131001. https:\/\/doi.org\/10.1093\/carcin\/23.6.993","journal-title":"Carcinogenesis"},{"key":"1592_CR52","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1096\/fj.00-0554fje","volume":"15","author":"D Sindram","year":"2001","unstructured":"Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien P-A (2001) Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: a Kupffer cell-mediated injury. FASEB J 15:1230\u20131232. https:\/\/doi.org\/10.1096\/fj.00-0554fje","journal-title":"FASEB J"},{"key":"1592_CR53","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/s0016-5085(96)70055-0","volume":"111","author":"II Singer","year":"1996","unstructured":"Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE, Stenson WF (1996) Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 111:871\u2013885. https:\/\/doi.org\/10.1016\/s0016-5085(96)70055-0","journal-title":"Gastroenterology"},{"key":"1592_CR54","doi-asserted-by":"publisher","first-page":"L363","DOI":"10.1152\/ajplung.00003.2003","volume":"286","author":"B Singh","year":"2004","unstructured":"Singh B, Pearce JW, Gamage LN, Janardhan K, Caldwell S (2004) Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation. Am J Phys Lung Cell Mol Phys 286:L363\u2013L372. https:\/\/doi.org\/10.1152\/ajplung.00003.2003","journal-title":"Am J Phys Lung Cell Mol Phys"},{"key":"1592_CR55","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1177\/096032719801701108","volume":"17","author":"A Spencer","year":"1998","unstructured":"Spencer A, Wilson S, Harpur E (1998) Gadolinium chloride toxicity in the mouse. Hum Exp Toxicol 17:633\u2013637. https:\/\/doi.org\/10.1177\/096032719801701108","journal-title":"Hum Exp Toxicol"},{"key":"1592_CR56","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1476-9255-6-34","volume":"6","author":"JL Strande","year":"2009","unstructured":"Strande JL, Routhu KV, Hsu A, Nicolosi AC, Baker JE (2009) Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury. J Inflamm 6:34. https:\/\/doi.org\/10.1186\/1476-9255-6-34","journal-title":"J Inflamm"},{"key":"1592_CR57","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/j.1440-1746.1994.tb01558.x","volume":"9","author":"H Suzuki","year":"1994","unstructured":"Suzuki H et al (1994) Sulfhydryl blocker-induced colitis in the rat: immunological changes in thymus gland and colonic mucosa. J Gastroenterol Hepatol 9:544\u2013550","journal-title":"J Gastroenterol Hepatol"},{"key":"1592_CR58","doi-asserted-by":"publisher","first-page":"3 20 21","DOI":"10.1002\/0471142735.im0320s110","volume":"110","author":"M Swamydas","year":"2015","unstructured":"Swamydas M, Luo Y, Dorf ME, Lionakis MS (2015) Isolation of mouse neutrophils. Curr Protoc Immunol 110:3 20 21\u201323 20 15. https:\/\/doi.org\/10.1002\/0471142735.im0320s110","journal-title":"Curr Protoc Immunol"},{"key":"1592_CR59","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/path.1824","volume":"207","author":"I Szanto","year":"2005","unstructured":"Szanto I, Rubbia-Brandt L, Kiss P, Steger K, Banfi B, Kovari E, Herrmann F, Hadengue A, Krause KH (2005) Expression ofNOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol 207:164\u2013176. https:\/\/doi.org\/10.1002\/path.1824","journal-title":"J Pathol"},{"key":"1592_CR60","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1089\/ars.2012.4827","volume":"18","author":"CC Winterbourn","year":"2013","unstructured":"Winterbourn CC, Kettle AJ (2013) Redox reactions and microbial killing in the neutrophil phagosome. Antioxid Redox Signal 18:642\u2013660. https:\/\/doi.org\/10.1089\/ars.2012.4827","journal-title":"Antioxid Redox Signal"},{"key":"1592_CR61","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/s0022-2143(03)00132-x","volume":"142","author":"T Yamada","year":"2003","unstructured":"Yamada T, Takahashi S, Masuda K, Ohara H, Nakazawa T, Sano H, Ando T, Nakamura S, Kobayashi S, Kuno A, Aoki S, Nomura T, Joh T, Itoh M (2003) Kupffer-cell depletion attenuates colonic and extracolonic granulomatous inflammation in chronic colitis. J Lab Clin Med 142:268\u2013277. https:\/\/doi.org\/10.1016\/s0022-2143(03)00132-x","journal-title":"J Lab Clin Med"},{"key":"1592_CR62","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1126\/science.2466333","volume":"243","author":"X Yang","year":"1989","unstructured":"Yang X, Sachs F (1989) Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science 243:1068\u20131071. https:\/\/doi.org\/10.1126\/science.2466333","journal-title":"Science"},{"key":"1592_CR63","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.3109\/00365521.2010.490596","volume":"45","author":"X Yang","year":"2010","unstructured":"Yang X, Meng S, Jiang H, Chen T, Wu W (2010) Exosomes derived from interleukin-10-treated dendritic cells can inhibit trinitrobenzene sulfonic acid-induced rat colitis. Scand J Gastroenterol 45:1168\u20131177. https:\/\/doi.org\/10.3109\/00365521.2010.490596","journal-title":"Scand J Gastroenterol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-018-1592-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-018-1592-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-018-1592-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:09:08Z","timestamp":1694102948000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-018-1592-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["1592"],"URL":"https:\/\/doi.org\/10.1007\/s00210-018-1592-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"assertion":[{"value":"23 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}