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All tests were achieved using mature male and female mice (3\u00a0months old; 25\u201335\u00a0g), bred in the animal house facility (controlled temperature (22\u2009\u00b1\u20091\u00a0\u00b0C); 12\u00a0h light\/12\u00a0h dark cycle with standard lab chow and water ad libitum) of the National Institute of Health (NIH), Islamabad, Pakistan. The treatment of animals was in agreement with the Institutional Animal Care and Use Committee (IACUC) of the National Institute of Health, and the study protocols accepted by the ethics committee of National Institute of Health, Islamabad, Pakistan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"A statement regarding consent for publication is not applicable for this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}