{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:36:14Z","timestamp":1772310974475,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"93.5-4.8"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s00210-019-01660-z","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T07:02:58Z","timestamp":1561186978000},"page":"1371-1382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pretreatment with vildagliptin boosts ischemic-postconditioning effects on cardioprotection and expression profile of genes regulating autophagy and mitochondrial fission\/fusion in diabetic heart with reperfusion injury"],"prefix":"10.1007","volume":"392","author":[{"given":"Lale","family":"Pirzeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahab","family":"Babapour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8092-7820","authenticated-orcid":false,"given":"Reza","family":"Badalzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Panahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"issue":"5","key":"1660_CR1","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/bph.12176","volume":"169","author":"N Apaijai","year":"2013","unstructured":"Apaijai N, Pintana H, Chattipakorn SC, Chattipakorn N (2013) Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats. Br J Pharmacol 169(5):1048\u20131057. \n                    https:\/\/doi.org\/10.1111\/bph.12176","journal-title":"Br J Pharmacol"},{"issue":"7","key":"1660_CR2","doi-asserted-by":"publisher","first-page":"e102374","DOI":"10.1371\/journal.pone.0102374","volume":"9","author":"N1 Apaijai","year":"2014","unstructured":"Apaijai N1, Chinda K, Palee S, Chattipakorn S, Chattipakorn N (2014) Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats. PLoS One 9(7):e102374. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0102374","journal-title":"PLoS One"},{"issue":"1","key":"1660_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s13105-016-0530-4","volume":"73","author":"R Badalzadeh","year":"2017","unstructured":"Badalzadeh R, Azimi A, Alihemmati A, Yousefi B (2017a) Chronic type-I diabetes could not impede the anti-inflammatory and antiapoptotic effects of combined postconditioning with ischemia and cyclosporine a in myocardial reperfusion injury. J Physiol Biochem 73(1):111\u2013120. \n                    https:\/\/doi.org\/10.1007\/s13105-016-0530-4","journal-title":"J Physiol Biochem"},{"issue":"10","key":"1660_CR4","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.22038\/IJBMS.2017.9444","volume":"20","author":"R Badalzadeh","year":"2017","unstructured":"Badalzadeh R, Tabatabaei SM, Mohammadi M, Khaki A, Mohammadnezhad D (2017b) Combined postconditioning with ischemia and cyclosporine-A restore oxidative stress and histopathological changes in reperfusion injury of diabetic myocardium. Iran J Basic Med Sci 20(10):1079\u20131087. \n                    https:\/\/doi.org\/10.22038\/IJBMS.2017.9444","journal-title":"Iran J Basic Med Sci"},{"issue":"2","key":"1660_CR5","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1177\/1074248417729881","volume":"23","author":"G Bayrami","year":"2018","unstructured":"Bayrami G, Karimi P, Agha-Hosseini F, Feyzizadeh S, Badalzadeh R (2018) Effect of ischemic postconditioning on myocardial function and infarct size following reperfusion injury in diabetic rats pretreated with vildagliptin. J Cardiovasc Pharmacol Ther 23(2):174\u2013183. \n                    https:\/\/doi.org\/10.1177\/1074248417729881","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"2","key":"1660_CR6","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ijcard.2012.10.046","volume":"168","author":"JA Finegold","year":"2013","unstructured":"Finegold JA, Asaria P, Francis DP (2013) Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations. Int J Cardiol 168(2):934\u2013945. \n                    https:\/\/doi.org\/10.1016\/j.ijcard.2012.10.046","journal-title":"Int J Cardiol"},{"key":"1660_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev-physiol-021909-135757","volume":"72","author":"RA Gottlieb","year":"2010","unstructured":"Gottlieb RA, Mentzer RM Jr (2010) Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol 72:45\u201359. \n                    https:\/\/doi.org\/10.1146\/annurev-physiol-021909-135757","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"1660_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00125-018-4801-1","volume":"62","author":"P Home","year":"2019","unstructured":"Home P (2019) Cardiovascular outcome trials of glucose-lowering medications: an update. Diabetologia. 62(3):357\u2013369. \n                    https:\/\/doi.org\/10.1007\/s00125-018-4801-1","journal-title":"Diabetologia."},{"key":"1660_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0076-6879(08)03613-6","volume":"452","author":"M Kadowaki","year":"2009","unstructured":"Kadowaki M, Karim MR (2009) Cytosolic LC3 ratio as a quantitative index of macroautophagy. Methods Enzymol 452:199\u2013213. \n                    https:\/\/doi.org\/10.1016\/S0076-6879(08)03613-6","journal-title":"Methods Enzymol"},{"issue":"2","key":"1660_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00210-017-1449-1","volume":"391","author":"JS Kim","year":"2018","unstructured":"Kim JS, Yi HK (2018) Schisandrin C enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms. Naunyn Schmiedeberg's Arch Pharmacol 391(2):197\u2013206. \n                    https:\/\/doi.org\/10.1007\/s00210-017-1449-1","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"issue":"1","key":"1660_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.21037\/acs.2018.01.10","volume":"7","author":"JGY Luc","year":"2018","unstructured":"Luc JGY, Choi JH, Rizvi SA, Phan K, MonchoEscriv\u00e0 E, Patel S, Reeves GR, Boyle AJ, Entwistle JW, Morris RJ, Massey HT, Tchantchaleishvili V (2018) Percutaneous coronary intervention versus coronary artery bypass grafting in heart transplant recipients with coronary allograft vasculopathy: a systematic review and meta-analysis of 1,520 patients. Ann Cardiothorac Surg 7(1):19\u201330. \n                    https:\/\/doi.org\/10.21037\/acs.2018.01.10","journal-title":"Ann Cardiothorac Surg"},{"issue":"2","key":"1660_CR12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bbadis.2014.05.010","volume":"1852","author":"Sai Ma","year":"2015","unstructured":"Ma S, Wang Y, Chen Y, Cao F (2015) The role of the autophagy in myocardial ischemia\/reperfusion injury. Biochim. Biophys Acta Mol Basis Dis 1852(2):271\u2013276. \n                    https:\/\/doi.org\/10.1016\/j.bbadis.2014.05.010","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"2","key":"1660_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1055\/s-0037-1613694","volume":"44","author":"S Maiocchi","year":"2018","unstructured":"Maiocchi S, Alwis I, Wu MCL, Yuan Y, Jackson SP (2018) Thromboinflammatory functions of platelets in ischemia-reperfusion injury and its dysregulation in diabetes. Semin Thromb Hemost 44(2):102\u2013113. \n                    https:\/\/doi.org\/10.1055\/s-0037-1613694","journal-title":"Semin Thromb Hemost"},{"issue":"11","key":"1660_CR14","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1111\/jcmm.13330","volume":"21","author":"C Maneechote","year":"2017","unstructured":"Maneechote C, Palee S, Chattipakorn SC, Chattipakorn N (2017) Roles of mitochondrial dynamics modulators in cardiac ischaemia\/reperfusion injury. J Cell Mol Med 21(11):2643\u20132653. \n                    https:\/\/doi.org\/10.1111\/jcmm.13330","journal-title":"J Cell Mol Med"},{"issue":"6","key":"1660_CR15","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","volume":"100","author":"Y Matsui","year":"2007","unstructured":"Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T (2007) Distinct roles of autophagy in the heart during ischemia and reperfusion. Circ Res 100(6):914\u2013922. \n                    https:\/\/doi.org\/10.1161\/01.RES.0000261924.76669.36","journal-title":"Circ Res"},{"key":"1660_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1475-2840-13-43","volume":"13","author":"T Miyoshi","year":"2014","unstructured":"Miyoshi T, Nakamura K, Yoshida M, Miura D, Oe H, Akagi S, Sugiyama H, Akazawa K, Yonezawa T, Wada J, Ito H (2014) Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats. Cardiovasc Diabetol 13:43. \n                    https:\/\/doi.org\/10.1186\/1475-2840-13-43","journal-title":"Cardiovasc Diabetol"},{"issue":"4","key":"1660_CR17","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell. 147(4):728\u2013741. \n                    https:\/\/doi.org\/10.1016\/j.cell.2011.10.026","journal-title":"Cell."},{"key":"1660_CR18","first-page":"155","volume":"3","author":"PE Munasinghe","year":"2016","unstructured":"Munasinghe PE, Katare R (2016) Maladaptive autophagy in diabetic heart disease. Int J ClinExpPhysiol 3:155\u2013165 \n                    http:\/\/www.ijcep.org\/text.asp?2016\/3\/4\/155\/196893","journal-title":"Int J ClinExpPhysiol"},{"issue":"14","key":"1660_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12933-015-0264-6","volume":"11","author":"H Murase","year":"2015","unstructured":"Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Ishikawa S, Tobisawa T, Ogasawara M, Nishizawa K, Miura T (2015) Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats. Cardiovasc Diabetol 11(14):103. \n                    https:\/\/doi.org\/10.1186\/s12933-015-0264-6","journal-title":"Cardiovasc Diabetol"},{"key":"1660_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/8237264","volume":"8237264","author":"VH Oidor-Chan","year":"2016","unstructured":"Oidor-Chan VH, Hong E, P\u00e9rez-Severiano F, Montes S, Torres-Narv\u00e1ez JC, Del Valle-Mondrag\u00f3n L, Pastel\u00edn-Hern\u00e1ndez G, S\u00e1nchez-Mendoza A (2016) Fenofibrate plus metformin produces cardioprotection in a type 2 diabetes and acute myocardial infarction model. PPAR Res 8237264:1\u201314. \n                    https:\/\/doi.org\/10.1155\/2016\/8237264","journal-title":"PPAR Res"},{"issue":"18","key":"1660_CR21","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1161\/CIRCULATIONAHA.109.906610","volume":"121","author":"SB Ong","year":"2010","unstructured":"Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM, Hausenloy DJ (2010) Inhibiting mitochondrial fission protects the heart against ischemia\/reperfusion injury. Circulation. 121(18):2012\u20132022. \n                    https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.906610","journal-title":"Circulation."},{"issue":"1","key":"1660_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/antiox7010013","volume":"7","author":"J Orcid","year":"2018","unstructured":"Orcid J, Cooper KF, Strich R (2018) Reactive oxygen species and mitochondrial dynamics: the yin and Yang of mitochondrial dysfunction and cancer progression. Antioxidants 7(1):13. \n                    https:\/\/doi.org\/10.3390\/antiox7010013","journal-title":"Antioxidants"},{"issue":"32","key":"1660_CR23","doi-asserted-by":"publisher","first-page":"e4543","DOI":"10.1097\/MD.0000000000004543","volume":"95","author":"SH Park","year":"2016","unstructured":"Park SH, Nam JY, Han E, Lee YH, Lee BW, Kim BS, Cha BS, Kim CS, Kang ES (2016) Efficacy of different dipeptidyl peptidase-4 (DPP-4) inhibitors on metabolic parameters in patients with type 2 diabetes undergoing dialysis. Medicine(Baltimore) 95(32):e4543. \n                    https:\/\/doi.org\/10.1097\/MD.0000000000004543","journal-title":"Medicine(Baltimore)"},{"issue":"2","key":"1660_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/FJC.0000000000000549","volume":"71","author":"D Qiming","year":"2018","unstructured":"Qiming D, Yunhui X, Pauline M, Jennifer K, Eric M, Sandrine P (2018) Preconditioning and postconditioning by cardiac glycosides in the mouse heart. J Cardiovasc Pharmacol 71(2):95\u2013103. \n                    https:\/\/doi.org\/10.1097\/FJC.0000000000000549","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"1660_CR25","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/cvr\/cvs123","volume":"94","author":"S Ravassa","year":"2012","unstructured":"Ravassa S, Zudaire A, D\u00edez J (2012) GLP-1 and cardioprotection: from bench to bedside. Cardiovasc Res 94(2):316\u2013323. \n                    https:\/\/doi.org\/10.1093\/cvr\/cvs123","journal-title":"Cardiovasc Res"},{"key":"1660_CR26","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.redox.2017.01.013","volume":"11","author":"S Rovira-Llopis","year":"2017","unstructured":"Rovira-Llopis S, Ba\u00f1uls C, Diaz-Morales N, Hernandez-Mijares A, Rocha M, Victor VM (2017) Mitochondrial dynamics in type 2 diabetes: pathophysiological implications. Redox Biol 11:637\u2013645. \n                    https:\/\/doi.org\/10.1016\/j.redox.2017.01.013","journal-title":"Redox Biol"},{"issue":"14","key":"1660_CR27","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1177\/2047487318756420","volume":"25","author":"F Saeid","year":"2018","unstructured":"Saeid F, Aniseh J, Reza B, Manouchehr VS (2018) Signaling mediators modulated by cardioprotective interventions in healthy and diabetic myocardium with ischaemia-reperfusion injury. Eur J Prev Cardiol 25(14):1463\u20131481. \n                    https:\/\/doi.org\/10.1177\/2047487318756420","journal-title":"Eur J Prev Cardiol"},{"issue":"167","key":"1660_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.regpep.2011.01.003","volume":"11","author":"E Tomas","year":"2011","unstructured":"Tomas E, Stanojevic V, Habener JF (2011) GLP-1-derived nonapeptide GLP-1(28-36) amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes. Regul Pept 11(167):177\u2013184. \n                    https:\/\/doi.org\/10.1016\/j.regpep.2011.01.003","journal-title":"Regul Pept"},{"issue":"3","key":"1660_CR29","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/JP271301","volume":"594","author":"C Vasquez-Trincado","year":"2016","unstructured":"Vasquez-Trincado C, Garcia-Carvajal I, Pennanen C (2016) Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol 594(3):509\u2013525. \n                    https:\/\/doi.org\/10.1113\/JP271301","journal-title":"J Physiol"},{"issue":"1","key":"1660_CR30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12933-016-0452-z","volume":"15","author":"J Xie","year":"2016","unstructured":"Xie J, Cui K, Hao H, Zhang Y, Lin H, Chen Z (2016) Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation. Cardiovasc Diabetol 15(1):136. \n                    https:\/\/doi.org\/10.1186\/s12933-016-0452-z","journal-title":"Cardiovasc Diabetol"},{"issue":"6","key":"1660_CR31","doi-asserted-by":"publisher","first-page":"675","DOI":"10.4103\/0253-7613.194847","volume":"48","author":"R Yavari","year":"2016","unstructured":"Yavari R, Badalzadeh R, Alipour MR, Tabatabaei SM (2016) Modulation of hippocampal gene expression of microRNA-146a\/microRNA-155-nuclear factor-kappa B inflammatory signaling by troxerutin in healthy and diabetic rats. Indian J Pharm 48(6):675\u2013680. \n                    https:\/\/doi.org\/10.4103\/0253-7613.194847","journal-title":"Indian J Pharm"},{"issue":"1","key":"1660_CR32","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12933-017-0551-5","volume":"16","author":"A Younis","year":"2017","unstructured":"Younis A, Eskenazi D, Goldkorn R, Leor J, Naftali-Shani N, Fisman EZ, Tenenbaum A, Goldenberg I, Klempfner R (2017) The addition of vildagliptin to metformin prevents the elevation of interleukin 1\u00df in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, open-label study. Cardiovasc Diabetol 16(1):69. \n                    https:\/\/doi.org\/10.1186\/s12933-017-0551-5","journal-title":"Cardiovasc Diabetol"},{"issue":"2","key":"1660_CR33","doi-asserted-by":"publisher","first-page":"H579","DOI":"10.1152\/ajpheart.01064.2002","volume":"285","author":"ZQ Zhao","year":"2003","unstructured":"Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J (2003) Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 285(2):H579\u2013H588. \n                    https:\/\/doi.org\/10.1152\/ajpheart.01064.2002","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-019-01660-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-019-01660-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-019-01660-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T23:04:15Z","timestamp":1592694255000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-019-01660-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,22]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["1660"],"URL":"https:\/\/doi.org\/10.1007\/s00210-019-01660-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,22]]},"assertion":[{"value":"21 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal procedures and experimental interventions were carried out in accordance with the ethical guidelines and approved by the local Ethical Committee for Animal Research.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}