{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:06:28Z","timestamp":1769108788082,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2017GXNSFAA198214"],"award-info":[{"award-number":["2017GXNSFAA198214"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s00210-019-01661-y","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T11:19:38Z","timestamp":1557487178000},"page":"1121-1130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nobiletin protects against myocardial injury and myocardial apoptosis following coronary microembolization via activating PI3K\/Akt pathway in rats"],"prefix":"10.1007","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-291X","authenticated-orcid":false,"given":"Qing","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiulin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"issue":"6","key":"1661_CR1","doi-asserted-by":"publisher","first-page":"5408","DOI":"10.3892\/mmr.2016.5919","volume":"14","author":"J Bi","year":"2016","unstructured":"Bi J, Zhang H, Lu J, Lei W (2016) Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats[J]. Mol Med Rep 14(6):5408\u20135414","journal-title":"Mol Med Rep"},{"issue":"6","key":"1661_CR2","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00395-008-0745-9","volume":"103","author":"D B\u00f6se","year":"2008","unstructured":"B\u00f6se D, von Birgelen C, Zhou XY et al (2008) Impact of atherosclerotic plaque composition on coronary microembolization during percutaneous coronary interventions[J]. Basic Res Cardiol 103(6):587\u2013597","journal-title":"Basic Res Cardiol"},{"issue":"10","key":"1661_CR3","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1111\/jcmm.12342","volume":"18","author":"ZW Chen","year":"2014","unstructured":"Chen ZW, Qian JY, Ma JY, Chang SF, Yun H, Jin H, Sun AJ, Zou YZ, Ge JB (2014) TNF-\u03b1-induced cardiomyocyte apoptosis contributes to cardiac dysfunction after coronary microembolization in mini-pigs[J]. J Cell Mol Med 18(10):1953\u20131963","journal-title":"J Cell Mol Med"},{"issue":"6","key":"1661_CR4","first-page":"H2587","volume":"279","author":"H D\u00f6rge","year":"2000","unstructured":"D\u00f6rge H, Neumann T, Behrends M, Skyschally A, Schulz R, Kasper C, Erbel R, Heusch G (2000) Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation[J]. Am J Phys Heart Circ Phys 279(6):H2587\u2013H2592","journal-title":"Am J Phys Heart Circ Phys"},{"issue":"1","key":"1661_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1006\/jmcc.2001.1489","volume":"34","author":"H D\u00f6rge","year":"2002","unstructured":"D\u00f6rge H, Schulz R, Belosjorow S, Post H, van de Sand A, Konietzka I, Frede S, Hartung T, Vinten-Johansen J, Youker KA, Entman ML, Erbel R, Heusch G (2002) Coronary microembolization: the role of TNF-\u03b1 in contractile dysfunction[J]. J Mol Cell Cardiol 34(1):51\u201362","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"1661_CR6","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.bbrc.2018.02.003","volume":"496","author":"W He","year":"2018","unstructured":"He W, Su Q, Liang J, Sun Y, Wang X, Li L (2018) The protective effect of nicorandil on cardiomyocyte apoptosis after coronary microembolization by activating Nrf2\/HO-1 signaling pathway in rats[J]. Biochem Biophys Res Commun 496(4):1296\u20131301","journal-title":"Biochem Biophys Res Commun"},{"key":"1661_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijcard.2018.02.010","volume":"258","author":"G Heusch","year":"2018","unstructured":"Heusch G, Skyschally A, Kleinbongard P (2018) Coronary microembolization and microvascular dysfunction[J]. Int J Cardiol 258:17\u201323","journal-title":"Int J Cardiol"},{"key":"1661_CR8","first-page":"2918796","volume":"2016","author":"H Huang","year":"2016","unstructured":"Huang H, Li L, Shi W et al (2016) The multifunctional effects of nobiletin and its metabolites in vivo and in vitro[J]. Evid Based Complement Alternat Med 2016:2918796","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"1661_CR9","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s12013-011-9199-z","volume":"61","author":"L Li","year":"2011","unstructured":"Li L, Su Q, Wang Y, Dai R, Lu Y, Su B, Zhao Y (2011) Effect of atorvastatin (Lipitor) on myocardial apoptosis and caspase-8 activation following coronary microembolization[J]. Cell Biochem Biophys 61(2):399\u2013406","journal-title":"Cell Biochem Biophys"},{"issue":"2","key":"1661_CR10","first-page":"1470","volume":"16","author":"ZR Li","year":"2018","unstructured":"Li ZR, Yang L, Zhen J et al (2018) Nobiletin protects PC12 cells from ERS-induced apoptosis in OGD\/R injury via activation of the PI3K\/AKT pathway[J]. Exp Ther Med 16(2):1470\u20131476","journal-title":"Exp Ther Med"},{"issue":"1","key":"1661_CR11","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s12872-017-0704-1","volume":"17","author":"J Liang","year":"2017","unstructured":"Liang J, Li L, Sun Y, He W, Wang X, Su Q (2017) The protective effect of activating Nrf2\/HO-1 signaling pathway on cardiomyocyte apoptosis after coronary microembolization in rats[J]. BMC Cardiovasc Disord 17(1):272","journal-title":"BMC Cardiovasc Disord"},{"issue":"10","key":"1661_CR12","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.cjca.2015.01.013","volume":"31","author":"T Liu","year":"2015","unstructured":"Liu T, Zhou Y, Liu YC, Wang JY, Su Q, Tang ZL, Li L (2015) Coronary microembolization induces cardiomyocyte apoptosis through the LOX-1\u2013dependent endoplasmic reticulum stress pathway involving JNK\/P38 MAPK[J]. Can J Cardiol 31(10):1272\u20131281","journal-title":"Can J Cardiol"},{"issue":"2","key":"1661_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11130-006-0014-8","volume":"61","author":"Y Lu","year":"2006","unstructured":"Lu Y, Zhang C, Bucheli P, Wei D (2006) Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China[J]. Plant Foods Hum Nutr 61(2):55\u201363","journal-title":"Plant Foods Hum Nutr"},{"issue":"1","key":"1661_CR14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.neulet.2010.07.078","volume":"484","author":"Y Lu","year":"2010","unstructured":"Lu Y, Su M, Huang H, Lin-Li, Yuan CG (2010) Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide[J]. Neurosci Lett 484(1):6\u201311","journal-title":"Neurosci Lett"},{"issue":"9","key":"1661_CR15","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1161\/CIRCULATIONAHA.108.831453","volume":"119","author":"M Srinivasan","year":"2009","unstructured":"Srinivasan M, Rihal C, Holmes DR, Prasad A (2009) Adjunctive thrombectomy and distal protection in primary percutaneous coronary intervention: impact on microvascular perfusion and outcomes[J]. Circulation 119(9):1311\u20131319","journal-title":"Circulation"},{"issue":"59","key":"1661_CR16","doi-asserted-by":"publisher","first-page":"99347","DOI":"10.18632\/oncotarget.19966","volume":"8","author":"Q Su","year":"2017","unstructured":"Su Q, Li L, Zhao J et al (2017) Effects of nicorandil on PI3K\/Akt signaling pathway and its anti-apoptotic mechanisms in coronary microembolization in rats[J]. Oncotarget 8(59):99347\u201399358","journal-title":"Oncotarget"},{"issue":"4","key":"1661_CR17","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1159\/000490866","volume":"47","author":"Q Su","year":"2018","unstructured":"Su Q, Li L, Sun Y, Yang H, Ye Z, Zhao J (2018a) Effects of the TLR4\/Myd88\/NF-\u03baB signaling pathway on NLRP3 inflammasome in coronary microembolization-induced myocardial injury[J]. Cell Physiol Biochem 47(4):1497\u20131508","journal-title":"Cell Physiol Biochem"},{"key":"1661_CR18","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.biopha.2018.06.098","volume":"105","author":"Q Su","year":"2018","unstructured":"Su Q, Lv X, Sun Y, Yang H, Ye Z, Li L (2018b) Role of high mobility group A1\/nuclear factor-kappa B signaling in coronary microembolization-induced myocardial injury[J]. Biomed Pharmacother 105:1164\u20131171","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"1661_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.15420\/ecr.2017:23:14","volume":"12","author":"Y Sunagawa","year":"2017","unstructured":"Sunagawa Y, Funamoto M, Suzuki A et al (2017) A novel target molecule of nobiletin derived from citrus peels has a therapeutic potency against the development of heart failure[J]. Eur Cardiol Rev 12(2):105","journal-title":"Eur Cardiol Rev"},{"issue":"7","key":"1661_CR20","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1161\/01.RES.0000014451.75415.36","volume":"90","author":"M Thielmann","year":"2002","unstructured":"Thielmann M, D\u00f6rge H, Martin C et al (2002) Myocardial dysfunction with coronary microembolization: signal transduction through a sequence of nitric oxide, tumor necrosis factor-\u03b1, and sphingosine[J]. Circ Res 90(7):807\u2013813","journal-title":"Circ Res"},{"issue":"4","key":"1661_CR21","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1161\/01.RES.0000117306.10142.50","volume":"94","author":"D Torella","year":"2004","unstructured":"Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A (2004) Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression[J]. Circ Res 94(4):514\u2013524","journal-title":"Circ Res"},{"issue":"16","key":"1661_CR22","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.1111\/bph.13191","volume":"172","author":"S Vaiyapuri","year":"2015","unstructured":"Vaiyapuri S, Roweth H, Ali MS, Unsworth AJ, Stainer AR, Flora GD, Crescente M, Jones CI, Moraes LA, Gibbins JM (2015) Pharmacological actions of nobiletin in the modulation of platelet function[J]. Br J Pharmacol 172(16):4133\u20134145","journal-title":"Br J Pharmacol"},{"issue":"5","key":"1661_CR23","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1177\/1074248415624158","volume":"21","author":"J Wang","year":"2016","unstructured":"Wang J, Chen H, Su Q, Zhou Y, Liu T, Li L (2016) The PTEN\/Akt signaling pathway mediates myocardial apoptosis in swine after coronary microembolization[J]. J Cardiovasc Pharmacol Ther 21(5):471\u2013477","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"1","key":"1661_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.atherosclerosis.2004.07.034","volume":"178","author":"SC Whitman","year":"2005","unstructured":"Whitman SC, Kurowska EM, Manthey JA, Daugherty A (2005) Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages[J]. Atherosclerosis 178(1):25\u201332","journal-title":"Atherosclerosis"},{"issue":"2","key":"1661_CR25","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.bbrc.2017.08.064","volume":"492","author":"X Wu","year":"2017","unstructured":"Wu X, Zheng D, Qin Y, Liu Z, Zhang G, Zhu X, Zeng L, Liang Z (2017) Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats via restoring autophagy flux[J]. Biochem Biophys Res Commun 492(2):262\u2013268","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"1661_CR26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1515\/tnsci-2018-0031","volume":"9","author":"B Yang","year":"2018","unstructured":"Yang B, Wang J, Zhang N (2018) Effect of nobiletin on experimental model of epilepsy[J]. Transl Neurosci 9(1):211\u2013219","journal-title":"Transl Neurosci"},{"key":"1661_CR27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.brainres.2014.02.007","volume":"1559","author":"N Yasuda","year":"2014","unstructured":"Yasuda N, Ishii T, Oyama D, Fukuta T, Agato Y, Sato A, Shimizu K, Asai T, Asakawa T, Kan T, Yamada S, Ohizumi Y, Oku N (2014) Neuroprotective effect of nobiletin on cerebral ischemia\u2013reperfusion injury in transient middle cerebral artery-occluded rats[J]. Brain Res 1559:46\u201354","journal-title":"Brain Res"},{"key":"1661_CR28","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jep.2018.03.031","volume":"220","author":"X Yu","year":"2018","unstructured":"Yu X, Sun S, Guo Y, Liu Y, Yang D, Li G, L\u00fc S (2018) Citri Reticulatae Pericarpium (Chenpi): botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine[J]. J Ethnopharmacol 220:265\u2013282","journal-title":"J Ethnopharmacol"},{"key":"1661_CR29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainresbull.2013.04.009","volume":"96","author":"L Zhang","year":"2013","unstructured":"Zhang L, Zhao H, Zhang X, Chen L, Zhao X, Bai X, Zhang J (2013) Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat[J]. Brain Res Bull 96:45\u201353","journal-title":"Brain Res Bull"},{"issue":"1\u20132","key":"1661_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11010-016-2716-z","volume":"417","author":"N Zhang","year":"2016","unstructured":"Zhang N, Yang Z, Xiang SZ, Jin YG, Wei WY, Bian ZY, Deng W, Tang QZ (2016) Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy[J]. Mol Cell Biochem 417(1\u20132):87\u201396","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"1661_CR31","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1159\/000478960","volume":"42","author":"N Zhang","year":"2017","unstructured":"Zhang N, Wei WY, Yang Z, Che Y, Jin YG, Liao HH, Wang SS, Deng W, Tang QZ (2017) Nobiletin, a polymethoxy flavonoid, protects against cardiac hypertrophy induced by pressure-overload via inhibition of napdh oxidases and endoplasmic reticulum stress[J]. Cell Physiol Biochem 42(4):1313\u20131325","journal-title":"Cell Physiol Biochem"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-019-01661-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-019-01661-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-019-01661-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T23:06:25Z","timestamp":1588892785000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-019-01661-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["1661"],"URL":"https:\/\/doi.org\/10.1007\/s00210-019-01661-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]},"assertion":[{"value":"4 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Institutional Animal Care and Use Committees of Guangxi Medical University approved all experiments, and all procedures and processes in this study were conducted as set out by the National Institutes of Health Guidelines on the use of laboratory animals.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}