{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:14:26Z","timestamp":1779927266265,"version":"3.53.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s00210-019-01785-1","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T09:04:05Z","timestamp":1576659845000},"page":"777-784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adelmidrol protects against non-alcoholic steatohepatitis in mice"],"prefix":"10.1007","volume":"393","author":[{"given":"Mahitab Mohamed","family":"Nageeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monira Ismaeil","family":"Khatab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Ahmed","family":"Abdel-sameea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Abbas","family":"Teleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"1785_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/BF01972748","volume":"39","author":"L Aloe","year":"1993","unstructured":"Aloe L, Leon A, Levi-Montalcini R (1993) A proposed autacoid mechanism controlling mastocyte behaviour. Agents Actions 39:145\u2013147","journal-title":"Agents Actions"},{"issue":"1","key":"1785_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/liv.13643","volume":"38","author":"AR Ara\u00fajo","year":"2018","unstructured":"Ara\u00fajo AR, Rosso N, Bedogni G, Tiribelli C, Bellentani S (2018) Global epidemiology of non-alcoholic fatty liver disease\/non-alcoholic steatohepatitis: what we need in the future. Liver Int 38(1):47\u201351","journal-title":"Liver Int"},{"issue":"1","key":"1785_CR3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","volume":"257","author":"Y Arita","year":"1999","unstructured":"Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257(1):79\u201383","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"1785_CR4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/00024382-200405000-00002","volume":"21","author":"TV Arumugam","year":"2004","unstructured":"Arumugam TV, Shiels IA, Woodruff TM, Granger DN, Taylor SM (2004) The role of the complement system in ischemia-reperfusion injury. Shock 21(5):401\u2013409","journal-title":"Shock"},{"key":"1785_CR5","first-page":"593","volume-title":"Theory and practice of histological techniques","author":"JD Bancroft","year":"2002","unstructured":"Bancroft JD, Gamble M (2002) Theory and practice of histological techniques, 5th edn. Churchill Livingstone pub.: 172-5, Edinburgh, pp 593\u2013620","edition":"5"},{"key":"1785_CR6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.lfs.2015.02.003","volume":"127","author":"S Barbosa-da-Silva","year":"2015","unstructured":"Barbosa-da-Silva S, Souza-Mello V, Magliano DC, Marinho T, Aguila MB, Mandarim-de-Lacerda CA (2015) Singular effects of PPAR agonists on nonalcoholic fatty liver disease of diet-induced obese mice. Life Sci 127:73\u201381","journal-title":"Life Sci"},{"key":"1785_CR7","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Duron O, Kelly MB (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"key":"1785_CR8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/BF02172085","volume":"3","author":"B Bonavida","year":"1991","unstructured":"Bonavida B (1991) Immunomodulatory effect of tumor necrosis factor. Biotherapy 3:127\u2013133","journal-title":"Biotherapy"},{"key":"1785_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/path.4829","volume":"241","author":"JK Ching Lau","year":"2017","unstructured":"Ching Lau JK, Zhang X, Yu J (2017) Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances. J Pathol 241:36\u201344","journal-title":"J Pathol"},{"issue":"5","key":"1785_CR10","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1124\/mol.116.105668","volume":"90","author":"M Cordaro","year":"2016","unstructured":"Cordaro M, Impellizzeri D, Gugliandolo E, Siracusa R, Crupi R, Esposito E, Cuzzocrea S (2016) Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of inflammatory bowel disease. Mol Pharmacol 90(5):549\u2013561","journal-title":"Mol Pharmacol"},{"key":"1785_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1744-8069-7-3","volume":"7","author":"D De Filippis","year":"2011","unstructured":"De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T (2011) Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Mol Pain 7:3","journal-title":"Mol Pain"},{"issue":"1","key":"1785_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s13075-016-1189-5","volume":"18","author":"R Di Paola","year":"2016","unstructured":"Di Paola R, Fusco R, Impellizzeri D, Cordaro M, Britti D, Morittu VM, Evangelista M, Cuzzocrea S (2016) Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. Arthritis Res Ther 18(1):291","journal-title":"Arthritis Res Ther"},{"key":"1785_CR13","doi-asserted-by":"crossref","unstructured":"Fischer R, Maier O (2015) Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxidative Med Cell Longev 2015(610813)","DOI":"10.1155\/2015\/610813"},{"issue":"2","key":"1785_CR14","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s12072-013-9468-6","volume":"7","author":"M Ganz","year":"2013","unstructured":"Ganz M, Szabo G (2013) Immune and inflammatory pathways in NASH. Hepatol Int 7(2):771\u2013781","journal-title":"Hepatol Int"},{"key":"1785_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1124\/jpet.108.136903","volume":"326","author":"T Genovese","year":"2008","unstructured":"Genovese T, Esposito E, Mazzon E, Di Paola R, Meli R, Bramanti P, Piomeli D, Calignano A, Cuzzocrea S (2008) Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. J Pharmacol Exp Ther 326:12\u201323","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"1785_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2008.11.006","volume":"34","author":"JL Hanslick","year":"2009","unstructured":"Hanslick JL, Lau K, Noguchi KK, Olney JW, Zorumski CF, Mennerick S, Farber NB (2009) Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiol Dis 34(1):1\u201310","journal-title":"Neurobiol Dis"},{"key":"1785_CR17","first-page":"273","volume":"61","author":"KJ Helewski","year":"2010","unstructured":"Helewski KJ, Kowalczyk-Ziomek GI, Czecior E, Swietochowska E, Wielkoszynski T, Czuba ZP, Szliszka E, Krol W (2010) Administration of low doses of TNFa protects rat liver from ischemic damage and re-perfusion injury. J Physiol Pharmacol 61:273\u2013278","journal-title":"J Physiol Pharmacol"},{"key":"1785_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bcp.2016.09.001","volume":"119","author":"D Impellizzeri","year":"2016","unstructured":"Impellizzeri D, Di Paola R, Cordaro M, Gugliandolo E, Casili G, Morittu VM, Britti D, Esposito E, Cuzzocrea S (2016) Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation. Biochem Pharmacol 119:27\u201341","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"1785_CR19","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1111\/liv.13634","volume":"38","author":"MR Jain","year":"2018","unstructured":"Jain MR, Giri SR, Bhoi B, Trivedi C, Rath A, Rathod R, Ranvir R, Kadam S, Patel H, Swain P, Roy SS, Das N, Karmakar E, Wahli W, Patel PR (2018) Dual PPAR\u03b1\/\u03b3 agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models. Liver Int 38(6):1084\u20131094","journal-title":"Liver Int"},{"key":"1785_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13098-018-0307-8","volume":"10","author":"S Jensen","year":"2018","unstructured":"Jensen S, Hvid H, Damgaard J, Nygaard H, Ingvorsen C, Wulff EM, Lykkesfeldt J, Fledelius C (2018) Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague\u2013Dawley rats. Diabetol Metab Syndr 10:4","journal-title":"Diabetol Metab Syndr"},{"key":"1785_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0009-8981(99)00138-2","volume":"288","author":"T Koken","year":"1999","unstructured":"Koken T, Inal M (1999) The effect of nitric oxide on I\/R injury in rat liver. Clin Chim Acta 288:55\u201362","journal-title":"Clin Chim Acta"},{"issue":"3","key":"1785_CR22","doi-asserted-by":"publisher","first-page":"459","DOI":"10.18388\/abp.2016_1252","volume":"63","author":"DM Lebensztejn","year":"2016","unstructured":"Lebensztejn DM, Flisiak-Jackiewicz M, Bia\u0142okoz-Kalinowska I, Bobrus-Chociej A, Kowalska I (2016) Hepatokines and non-alcoholic fatty liver disease. Acta Biochim Pol 63(3):459\u2013467","journal-title":"Acta Biochim Pol"},{"issue":"2","key":"1785_CR23","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1160\/TH14-01-0007","volume":"112","author":"S Lenglet","year":"2014","unstructured":"Lenglet S, Montecucco F, Mach F, Schaller K, Gasche Y, Copin JC (2014) Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke. Thromb Haemost 112(2):363\u2013378","journal-title":"Thromb Haemost"},{"issue":"2","key":"1785_CR24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1053\/jhep.2000.9323","volume":"32","author":"A Lentsch","year":"2000","unstructured":"Lentsch A, Kato A, Yoshidome H, McMasters K, Edwards M (2000) Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia\/reperfusion injury. Hepatology 32(2):169\u2013173","journal-title":"Hepatology"},{"issue":"10","key":"1785_CR25","first-page":"266","volume":"4","author":"P Lizana","year":"2017","unstructured":"Lizana P, Galdames M, Rodrigo R (2017) Oxidative stress and endoplasmic reticulum stress as potential therapeutic targets in non-alcoholic fatty liver disease. React Oxygen Species 4(10):266\u2013274","journal-title":"React Oxygen Species"},{"issue":"2","key":"1785_CR26","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1006\/bbrc.1996.0587","volume":"221","author":"K Maeda","year":"1996","unstructured":"Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1). Biochem Biophys Res Commun 221(2):286\u2013289","journal-title":"Biochem Biophys Res Commun"},{"key":"1785_CR27","doi-asserted-by":"publisher","first-page":"5170402","DOI":"10.1155\/2016\/5170402","volume":"2016","author":"N Magee","year":"2016","unstructured":"Magee N, Zou A, Zhang Y (2016) Pathogenesis of nonalcoholic steatohepatitis: interactions between liver parenchymal and nonparenchymal cells. Biomed Res Int 2016:5170402","journal-title":"Biomed Res Int"},{"issue":"4","key":"1785_CR28","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1210\/en.2013-1823","volume":"155","author":"RG Mattace","year":"2014","unstructured":"Mattace RG, Santoro A, Russo R, Simeoli R, Paciello O, Di Carlo C, Diano S, Calignano A, Meli R (2014) Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats. Endocrinology. 155(4):1291\u20131301","journal-title":"Endocrinology."},{"issue":"6","key":"1785_CR29","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1161\/ATVBAHA.111.225383","volume":"31","author":"K Nakaya","year":"2011","unstructured":"Nakaya K, Tohyama J, Naik SU, Tanigawa H, MacPhee C, Billheimer JT, Rader DJ (2011) Peroxisome proliferator-activated receptor activation promotes macrophage reverse cholesterol transport through a liver X receptor\u2013dependent pathway. Arterioscler Thromb Vasc Biol 31(6):1276\u20131282","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1785_CR30","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0190-9622(87)70294-1","volume":"17","author":"M Nazzaro-Porro","year":"1987","unstructured":"Nazzaro-Porro M (1987) Azelaic acid. J Am Acad Dermatol 17:1033\u20131041","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"1785_CR31","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.3390\/cancers6031220","volume":"6","author":"I Okazaki","year":"2014","unstructured":"Okazaki I, Noro T, Tsutsui N, Yamanouchi E, Kuroda H, Nakano M, Yokomori H, Inagaki Y (2014) Fibrogenesis and carcinogenesis in nonalcoholic steatohepatitis (NASH): involvement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs). Cancers (Basel) 6(3):1220\u20131255","journal-title":"Cancers (Basel)"},{"key":"1785_CR32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1475-2840-12-46","volume":"12","author":"MS Peter","year":"2013","unstructured":"Peter MS, Markus R, Christian S, Christoph B, Guenter AR, Andreas L, Dierk HE (2013) Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats. Cardiovasc Diabetol 12:46","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"1785_CR33","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel S (1957) A colorimetricmethod for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28(1):56\u201363","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"1785_CR34","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1155\/2010\/248321","volume":"29","author":"N Sandhya","year":"2010","unstructured":"Sandhya N, Gokulakrishnan K, Ravikumar R, Mohan V, Balasubramanyam M (2010) Association of hypoadiponectinemia with hypoglutathionemia in NAFLD subjects with and without type 2 diabetes. Dis Markers 29(5):213\u2013221","journal-title":"Dis Markers"},{"key":"1785_CR35","doi-asserted-by":"publisher","first-page":"40220","DOI":"10.1038\/srep40220","volume":"7","author":"M Siersb\u00e6k","year":"2017","unstructured":"Siersb\u00e6k M, Varticovski L, Yang S, Baek S, Nielsen R, Mandrup S, Hager GL, Chung JH, Gr\u00f8ntved L (2017) High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss. Sci Rep 7:40220","journal-title":"Sci Rep"},{"key":"1785_CR36","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.2741\/2034","volume":"11","author":"GN Smith","year":"2006","unstructured":"Smith GN (2006) The role of collagenolytic matrix metalloproteinases in the loss of articular cartilage in osteoarthritis. Front Biosci 11:3081\u20133095","journal-title":"Front Biosci"},{"issue":"42","key":"1785_CR37","doi-asserted-by":"publisher","first-page":"15539","DOI":"10.3748\/wjg.v20.i42.15539","volume":"20","author":"Y Takahashi","year":"2014","unstructured":"Takahashi Y, Fukusato T (2014) Histopathology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis. World J Gastroenterol 20(42):15539\u201315548","journal-title":"World J Gastroenterol"},{"issue":"2","key":"1785_CR38","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1365-2796.2004.01426.x","volume":"257","author":"ME Trujillo","year":"2005","unstructured":"Trujillo ME, Scherer PE (2005) Adiponectin\u2013journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 257(2):167\u2013175","journal-title":"J Intern Med"},{"issue":"5","key":"1785_CR39","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s11894-016-0498-9","volume":"18","author":"V Uppal","year":"2016","unstructured":"Uppal V, Mansoor S, Furuya K (2016) Pediatric non-alcoholic fatty liver disease. Curr Gastroenterol Rep 18(5):24","journal-title":"Curr Gastroenterol Rep"},{"issue":"2","key":"1785_CR40","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.chemphyslip.2011.11.010","volume":"165","author":"L Yang","year":"2012","unstructured":"Yang L, Fan B, Yang K, Zhu H (2012) A simple and sensitive method for lipoprotein and lipids profiles analysis of individual micro-liter scale serum samples. Chem Phys Lipids 165(2):133\u2013141","journal-title":"Chem Phys Lipids"},{"issue":"5","key":"1785_CR41","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1042\/CS20070347","volume":"114","author":"W Zhu","year":"2008","unstructured":"Zhu W, Cheng KK, Vanhoutte PM, Lam KS, Xu A (2008) Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci 114(5):361\u2013374","journal-title":"Clin Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-019-01785-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-019-01785-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-019-01785-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:54:39Z","timestamp":1608166479000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-019-01785-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["1785"],"URL":"https:\/\/doi.org\/10.1007\/s00210-019-01785-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]},"assertion":[{"value":"25 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental protocols were approved by the Ethics Committee of Zagazig University. The study was approved by the local Animal Ethical Committee of Zagazig University, Egypt. All experimental procedures were carried out in accordance with the guidelines set forth by the National Institutes of Health (USA).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}