{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:37:23Z","timestamp":1792291043833,"version":"4.4.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["94S176"],"award-info":[{"award-number":["94S176"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00210-020-01877-3","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T06:02:37Z","timestamp":1589436157000},"page":"1825-1833","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Pretreatment with berberine protects against cisplatin-induced renal injury in male Wistar rats"],"prefix":"10.1007","volume":"393","author":[{"given":"Hesameddin","family":"Allameh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Fatemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Reza","family":"Malayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nesari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Mehrzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"1877_CR1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) [13] Catalase in vitro. Methods Enzymol 105:121\u2013126","journal-title":"Methods Enzymol"},{"key":"1877_CR2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.pharep.2015.03.002","volume":"67","author":"T Ahmed","year":"2015","unstructured":"Ahmed T, Gilani AU, Abdollahi M, Daglia M, Nabavi SF, Nabavi SM (2015) Berberine and neurodegeneration: a review of literature. Pharmacol Rep 67:970\u2013979 Eng","journal-title":"Pharmacol Rep"},{"key":"1877_CR3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2015.12.019","volume":"91","author":"M Assi","year":"2016","unstructured":"Assi M, Derbr\u00e9 F, Lefeuvre-Orfila L, R\u00e9billard A (2016) Antioxidant supplementation accelerates cachexia development by promoting tumor growth in C26 tumor-bearing mice. Free Radic Biol Med 91:204\u2013214","journal-title":"Free Radic Biol Med"},{"key":"1877_CR4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1742-7843.2007.00060.x","volume":"100","author":"A Atessahin","year":"2007","unstructured":"Atessahin A, Ceribasi AO, Yuce A, Bulmus O, Cikim G (2007) Role of ellagic acid against cisplatin-induced nephrotoxicity and oxidative stress in rats. Basic Clin Pharmacol Toxicol 100:121\u2013126 Eng","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1877_CR5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tox.2005.04.016","volume":"212","author":"A Atessahin","year":"2005","unstructured":"Atessahin A, Yilmaz S, Karahan I, Ceribasi AO, Karaoglu A (2005) Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology 212:116\u2013123 Eng","journal-title":"Toxicology"},{"key":"1877_CR6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/13813455.2015.1068336","volume":"121","author":"S Bakir","year":"2015","unstructured":"Bakir S, Yazgan UC, Ibiloglu I, Elbey B, Kizil M, Kelle M (2015) The protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissue. Arch Physiol Biochem 121:152\u2013156 Eng","journal-title":"Arch Physiol Biochem"},{"key":"1877_CR7","first-page":"563","volume":"22","author":"G Bazmandegan","year":"2019","unstructured":"Bazmandegan G, Amirteimoury M, Kaeidi A, Shamsizadeh A, Khademalhosseini M, Nematollahi MH, Hassanipour M, Fatemi I (2019) Sumatriptan ameliorates renal injury induced by cisplatin in mice. Iranian J Basic Med Sci 22:563","journal-title":"Iranian J Basic Med Sci"},{"key":"1877_CR8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","author":"PP Bradley","year":"1982","unstructured":"Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Investig Dermatol 78:206\u2013209","journal-title":"J Investig Dermatol"},{"key":"1877_CR9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","volume":"52","author":"JA Buege","year":"1978","unstructured":"Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302\u2013310","journal-title":"Methods Enzymol"},{"key":"1877_CR10","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.foodchem.2011.05.075","volume":"129","author":"N Chandrasekara","year":"2011","unstructured":"Chandrasekara N, Shahidi F (2011) Antioxidative potential of cashew phenolics in food and biological model systems as affected by roasting. Food Chem 129:1388\u20131396","journal-title":"Food Chem"},{"key":"1877_CR11","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.3892\/mmr.2016.5017","volume":"13","author":"X Chen","year":"2016","unstructured":"Chen X, Zhang Y, Zhu Z, Liu H, Guo H, Xiong C, Xie K, Zhang X, Su S (2016) Protective effect of berberine on doxorubicin-induced acute hepatorenal toxicity in rats. Mol Med Rep 13:3953\u20133960 Eng","journal-title":"Mol Med Rep"},{"key":"1877_CR12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2019.12.011","volume":"318","author":"Y Cheng","year":"2019","unstructured":"Cheng Y, Ji Y (2019) Mitochondria-targeting nanomedicine self-assembled from GSH-responsive paclitaxel-ss-berberine conjugate for synergetic cancer treatment with enhanced cytotoxicity. J Control Release 318:38\u201349 Eng","journal-title":"J Control Release"},{"key":"1877_CR13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2007.12.007","volume":"245","author":"YI Chirino","year":"2008","unstructured":"Chirino YI, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Cruz C, Pedraza-Chaverri J (2008) Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity. Toxicology 245:18\u201323 Eng","journal-title":"Toxicology"},{"key":"1877_CR14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/00015458.2018.1455418","volume":"119","author":"F Dehnamaki","year":"2019","unstructured":"Dehnamaki F, Karimi A, Pilevarian AA, Fatemi I, Hakimizadeh E, Kaeidi A, Allahtavakoli M, Rahmani MR, Khademalhosseini M, Bazmandegan G (2019) Treatment with troxerutin protects against cisplatin-induced kidney injury in mice. Acta Chir Belg 119:31\u201337","journal-title":"Acta Chir Belg"},{"key":"1877_CR15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/1568026613666131213155252","volume":"14","author":"G Derosa","year":"2014","unstructured":"Derosa G, Maffioli P (2014) Alkaloids in the nature: pharmacological applications in clinical practice of berberine and mate tea. Curr Top Med Chem 14:200\u2013206 Eng","journal-title":"Curr Top Med Chem"},{"key":"1877_CR16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fct.2013.09.003","volume":"62","author":"R Domitrovic","year":"2013","unstructured":"Domitrovic R, Cvijanovic O, Pernjak-Pugel E, Skoda M, Mikelic L, Crncevic-Orlic Z (2013) Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative\/nitrosative stress, inflammation, autophagy and apoptosis. Food Chem Toxicol 62:397\u2013406 Eng","journal-title":"Food Chem Toxicol"},{"key":"1877_CR17","doi-asserted-by":"crossref","first-page":"591654","DOI":"10.1155\/2012\/591654","volume":"2012","author":"H Dong","year":"2012","unstructured":"Dong H, Wang N, Zhao L, Lu F (2012) Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med 2012:591654 Eng","journal-title":"Evid Based Complement Alternat Med"},{"key":"1877_CR18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/0886022X.2017.1326384","volume":"39","author":"V Ehsani","year":"2017","unstructured":"Ehsani V, Amirteimoury M, Taghipour Z, Shamsizadeh A, Bazmandegan G, Rahnama A, Khajehasani F, Fatemi I (2017) Protective effect of hydroalcoholic extract of Pistacia vera against gentamicin-induced nephrotoxicity in rats. Ren Fail 39:519\u2013525","journal-title":"Ren Fail"},{"key":"1877_CR19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"1877_CR20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1749-8546-5-33","volume":"5","author":"Y Feng","year":"2010","unstructured":"Feng Y, Siu KY, Ye X, Wang N, Yuen MF, Leung CH, Tong Y, Kobayashi S (2010) Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin Med 5:33 Eng","journal-title":"Chin Med"},{"key":"1877_CR21","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00432-014-1665-8","volume":"140","author":"MO Germoush","year":"2014","unstructured":"Germoush MO, Mahmoud AM (2014) Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines. J Cancer Res Clin Oncol 140:1103\u20131109 Eng","journal-title":"J Cancer Res Clin Oncol"},{"key":"1877_CR22","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1080\/10286020.2017.1384819","volume":"20","author":"H Ghaznavi","year":"2018","unstructured":"Ghaznavi H, Fatemi I, Kalantari H, Hosseini Tabatabaei SMT, Mehrabani M, Gholamine B, Kalantar M, Mehrzadi S, Goudarzi M (2018) Ameliorative effects of gallic acid on gentamicin-induced nephrotoxicity in rats. J Asian Nat Prod Res 20:1182\u20131193","journal-title":"J Asian Nat Prod Res"},{"key":"1877_CR23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/2156587215621672","volume":"21","author":"H Ghaznavi","year":"2016","unstructured":"Ghaznavi H, Mehrzadi S, Dormanesh B, Tabatabaei SMTH, Vahedi H, Hosseinzadeh A, Pazoki-Toroudi H, Rashidian A (2016) Comparison of the protective effects of melatonin and silymarin against gentamicin-induced nephrotoxicity in rats. J Evid Based Complement Alternat Med 21:49\u201355","journal-title":"J Evid Based Complement Alternat Med"},{"key":"1877_CR24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12012-018-9446-2","volume":"18","author":"M Goudarzi","year":"2018","unstructured":"Goudarzi M, Fatemi I, Siahpoosh A, Sezavar SH, Mansouri E, Mehrzadi S (2018) Protective effect of ellagic acid against sodium arsenite-induced cardio- and hematotoxicity in rats. Cardiovasc Toxicol 18:337\u2013345 Eng","journal-title":"Cardiovasc Toxicol"},{"key":"1877_CR25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/fcp.12303","volume":"31","author":"M Goudarzi","year":"2017","unstructured":"Goudarzi M, Khodayar MJ, Hosseini Tabatabaei SMT, Ghaznavi H, Fatemi I, Mehrzadi S (2017) Pretreatment with melatonin protects against cyclophosphamide-induced oxidative stress and renal damage in mice. Fundam Clin Pharmacol 31:625\u2013635","journal-title":"Fundam Clin Pharmacol"},{"key":"1877_CR26","first-page":"1525","volume":"40","author":"Y Huang","year":"2018","unstructured":"Huang Y, Wang K, Gu C, Yu G, Zhao D, Mai W, Zhong Y, Liu S, Nie Y, Yang H (2018) Berberine, a natural plant alkaloid, synergistically sensitizes human liver cancer cells to sorafenib. Oncol Rep 40:1525\u20131532 Eng","journal-title":"Oncol Rep"},{"key":"1877_CR27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.biopha.2016.04.027","volume":"81","author":"SA Javad-Mousavi","year":"2016","unstructured":"Javad-Mousavi SA, Hemmati AA, Mehrzadi S, Hosseinzadeh A, Houshmand G, Nooshabadi MRR, Mehrabani M, Goudarzi M (2016) Protective effect of Berberis vulgaris fruit extract against Paraquat-induced pulmonary fibrosis in rats. Biomed Pharmacother 81:329\u2013336","journal-title":"Biomed Pharmacother"},{"key":"1877_CR28","doi-asserted-by":"crossref","unstructured":"Jin H, Ko YS, Park SW, Chang KC, Kim HJ (2019) 13-Ethylberberine induces apoptosis through the mitochondria-related apoptotic pathway in radiotherapy-resistant breast cancer cells. Molecules (Basel, Switzerland) 4:2448 Eng","DOI":"10.3390\/molecules24132448"},{"key":"1877_CR29","doi-asserted-by":"crossref","unstructured":"Kwon S, Chan AT (2020) Extracting the benefits of berberine for colorectal cancer. lancet Gastroenterol Hepatol 5:231\u2013233 Eng","DOI":"10.1016\/S2468-1253(19)30430-3"},{"key":"1877_CR30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3109\/13880209.2012.655377","volume":"50","author":"T Lao-ong","year":"2012","unstructured":"Lao-ong T, Chatuphonprasert W, Nemoto N, Jarukamjorn K (2012) Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine. Pharm Biol 50:1007\u20131012 Eng","journal-title":"Pharm Biol"},{"key":"1877_CR31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","volume":"233","author":"RL Levine","year":"1994","unstructured":"Levine RL, Williams JA, Stadtman EP, Shacter E (1994) Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 233:346\u2013357","journal-title":"Methods Enzymol"},{"key":"1877_CR32","doi-asserted-by":"crossref","first-page":"117228","DOI":"10.1016\/j.lfs.2019.117228","volume":"242","author":"J Liu","year":"2020","unstructured":"Liu J, Zhu Z, Liu Y, Wei L, Li B, Mao F, Zhang J, Wang Y, Liu Y (2020) MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells. Life Sci 242:117228 Eng","journal-title":"Life Sci"},{"key":"1877_CR33","doi-asserted-by":"crossref","first-page":"109794","DOI":"10.1016\/j.biopha.2019.109794","volume":"123","author":"TZ Lopes","year":"2020","unstructured":"Lopes TZ, de Moraes FR, Tedesco AC, Arni RK, Rahal P, Calmon MF (2020) Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells. Biomed Pharmacother 123:109794 Eng","journal-title":"Biomed Pharmacother"},{"key":"1877_CR34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0003-9861(87)90400-0","volume":"255","author":"JP Martin","year":"1987","unstructured":"Martin JP, Dailey M, Sugarman E (1987) Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys 255:329\u2013336","journal-title":"Arch Biochem Biophys"},{"key":"1877_CR35","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.pharep.2018.02.007","volume":"70","author":"S Mehrzadi","year":"2018","unstructured":"Mehrzadi S, Fatemi I, Malayeri AR, Khodadadi A, Mohammadi F, Mansouri E, Rashno M, Goudarzi M (2018) Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats. Pharmacol Rep 70:712\u2013719","journal-title":"Pharmacol Rep"},{"key":"1877_CR36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1139\/cjpp-2015-0277","volume":"94","author":"S Mehrzadi","year":"2015","unstructured":"Mehrzadi S, Kamrava SK, Dormanesh B, Motevalian M, Hosseinzadeh A, Hosseini Tabatabaei SMT, Ghaznavi H (2015) Melatonin synergistically enhances protective effect of atorvastatin against gentamicin-induced nephrotoxicity in rat kidney. Can J Physiol Pharmacol 94:265\u2013271","journal-title":"Can J Physiol Pharmacol"},{"key":"1877_CR37","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","volume":"2","author":"RP Miller","year":"2010","unstructured":"Miller RP, Tadagavadi RK, Ramesh G, Reeves WB (2010) Mechanisms of Cisplatin nephrotoxicity. Toxins 2:2490\u20132518 Eng","journal-title":"Toxins"},{"key":"1877_CR38","first-page":"124","volume":"5","author":"TB Mojarad","year":"2014","unstructured":"Mojarad TB, Roghani M (2014) The anticonvulsant and antioxidant effects of Berberine in Kainate-induced temporal lobe epilepsy in rats. Basic Clin Neurosci 5:124\u2013130 Eng","journal-title":"Basic Clin Neurosci"},{"key":"1877_CR39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.fct.2014.04.012","volume":"69","author":"MS Othman","year":"2014","unstructured":"Othman MS, Safwat G, Aboulkhair M, Moneim AEA (2014) The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats. Food Chem Toxicol 69:175\u2013181","journal-title":"Food Chem Toxicol"},{"key":"1877_CR40","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.7314\/APJCP.2015.16.13.5371","volume":"16","author":"V Pongkittiphan","year":"2015","unstructured":"Pongkittiphan V, Chavasiri W, Supabphol R (2015) Antioxidant effect of berberine and its phenolic derivatives against human fibrosarcoma cells. Asian Pac J Cancer Prev 16:5371\u20135376 Eng","journal-title":"Asian Pac J Cancer Prev"},{"key":"1877_CR41","first-page":"516","volume":"20","author":"SZK Rad","year":"2017","unstructured":"Rad SZK, Rameshrad M, Hosseinzadeh H (2017) Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: a review. Iran J Basic Med Sci 20:516","journal-title":"Iran J Basic Med Sci"},{"key":"1877_CR42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1742-7843.2005.pto_114.x","volume":"97","author":"S Saleh","year":"2005","unstructured":"Saleh S, El-Demerdash E (2005) Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide. Basic Clin Pharmacol Toxicol 97:91\u201397 Eng","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1877_CR43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1139\/Y09-136","volume":"88","author":"LK Sarna","year":"2010","unstructured":"Sarna LK, Wu N, Hwang SY, Siow YL, Karmin O (2010) Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophages. Can J Physiol Pharmacol 88:369\u2013378 eng","journal-title":"Can J Physiol Pharmacol"},{"key":"1877_CR44","doi-asserted-by":"crossref","first-page":"1221S","DOI":"10.1093\/jn\/126.suppl_4.1221S","volume":"126","author":"JL Schwartz","year":"1996","unstructured":"Schwartz JL (1996) The dual roles of nutrients as antioxidants and prooxidants: their effects on tumor cell growth. J Nutr 126:1221S\u20131227S","journal-title":"J Nutr"},{"key":"1877_CR45","first-page":"36","volume":"23","author":"Z Taghipour","year":"2019","unstructured":"Taghipour Z, Kaviani E, Kaeidi A, Shamsizadeh A, Hassanshahi J, Fatemi I (2019) Atorvastatin attenuates D-galactose-induced hepatorenal toxicity in mice: an experimental study with histopathological evaluations. Physiology and Pharmacology 23:36\u201343","journal-title":"Physiology and Pharmacology"},{"key":"1877_CR46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jep.2009.08.009","volume":"126","author":"J Tang","year":"2009","unstructured":"Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y (2009) Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J Ethnopharmacol 126:5\u201317 Eng","journal-title":"J Ethnopharmacol"},{"key":"1877_CR47","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bcp.2012.07.018","volume":"84","author":"M Tillhon","year":"2012","unstructured":"Tillhon M, Guaman Ortiz LM, Lombardi P, Scovassi AI (2012) Berberine: new perspectives for old remedies. Biochem Pharmacol 84:1260\u20131267 Eng","journal-title":"Biochem Pharmacol"},{"key":"1877_CR48","first-page":"922","volume":"252","author":"WR Tracey","year":"1990","unstructured":"Tracey WR, Linden J, Peach MJ, Johns RA (1990) Comparison of spectrophotometric and biological assays for nitric oxide (NO) and endothelium-derived relaxing factor (EDRF): nonspecificity of the diazotization reaction for NO and failure to detect EDRF. J Pharmacol Exp Ther 252:922\u2013928","journal-title":"J Pharmacol Exp Ther"},{"key":"1877_CR49","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.3892\/or.2017.5499","volume":"37","author":"J Wang","year":"2017","unstructured":"Wang J, Kang M, Wen Q, Qin YT, Wei ZX, Xiao JJ, Wang RS (2017) Berberine sensitizes nasopharyngeal carcinoma cells to radiation through inhibition of Sp1 and EMT. Oncol Rep 37:2425\u20132432 Eng","journal-title":"Oncol Rep"},{"key":"1877_CR50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MAJ.0b013e31812dfe1e","volume":"334","author":"X Yao","year":"2007","unstructured":"Yao X, Panichpisal K, Kurtzman N, Nugent K (2007) Cisplatin nephrotoxicity: a review. Am J Med Sci 334:115\u2013124 Eng","journal-title":"Am J Med Sci"},{"key":"1877_CR51","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.metabol.2008.01.013","volume":"57","author":"J Yin","year":"2008","unstructured":"Yin J, Xing H, Ye J (2008) Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 57:712\u2013717","journal-title":"Metabolism."},{"key":"1877_CR52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1248\/bpb.31.1169","volume":"31","author":"JY Zhou","year":"2008","unstructured":"Zhou JY, Zhou SW, Zhang KB, Tang JL, Guang LX, Ying Y, Xu Y, Zhang L, Li DD (2008) Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol Pharm Bull 31:1169\u20131176","journal-title":"Biol Pharm Bull"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01877-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01877-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01877-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T02:22:38Z","timestamp":1696126958000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-020-01877-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,14]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1877"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-01877-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,14]]},"assertion":[{"value":"25 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experiments were performed according to the Animal Ethics Committee Guidelines for the use of experimental animals (ethical code: IR.AJUMS.REC.1395.145).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}