{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:19:27Z","timestamp":1779365967430,"version":"3.53.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406177\/2016-3"],"award-info":[{"award-number":["406177\/2016-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01239-16 and PPM-00383-18"],"award-info":[{"award-number":["APQ-01239-16 and PPM-00383-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/22046-8"],"award-info":[{"award-number":["2015\/22046-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00210-020-01906-1","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T05:02:41Z","timestamp":1590037361000},"page":"1899-1910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2"],"prefix":"10.1007","volume":"393","author":[{"given":"Bruna Pinheiro","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Tavares","family":"do Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno C\u00e9sar C\u00f4rrea","family":"Salles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Cristinne Mancini","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilene Lopes","family":"\u00c2ngelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Helena Lobo","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia Graciela","family":"Ruginsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Renato","family":"Tirapelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Borges","family":"de Ara\u00fajo Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-5792","authenticated-orcid":false,"given":"Carla Speroni","family":"Ceron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"issue":"2","key":"1906_CR1","first-page":"167-36","volume":"36","author":"B Aras","year":"2010","unstructured":"Aras B, Tu\u011fcu V, Eren G, Mutlu B, Uhri M, \u00d6zbek E, Ta\u015f\u00e7\u0131 AI (2010) Protective effect of pyrrolidine dithiocarbamate on kidney tissue in streptozotocin-induced diabetic rats. Turk J Urol 36(2):167-36\u2013167-175","journal-title":"Turk J Urol"},{"key":"1906_CR2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1586\/eem.09.70","volume":"5","author":"FC Brosius","year":"2010","unstructured":"Brosius FC, Khoury CC, Buller CL, Chen S (2010) Abnormalities in signaling pathways in diabetic nephropathy. Expert Rev Endocrinol Metab 5:51\u201364","journal-title":"Expert Rev Endocrinol Metab"},{"key":"1906_CR3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1476-5381.2011.01360.x","volume":"164","author":"SB Cau","year":"2011","unstructured":"Cau SB, Guimaraes DA, Rizzi E, Ceron CS, Souza LL, Tirapelli CR, Gerlach RF, Tanus-Santos JE (2011) Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension. Br J Pharmacol 164:372\u2013381","journal-title":"Br J Pharmacol"},{"key":"1906_CR4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/bcpt.12400","volume":"117","author":"SB Cau","year":"2015","unstructured":"Cau SB, Guimaraes DA, Rizzi E, Ceron CS, Gerlach RF, Tanus-Santos JE (2015) The nuclear factor kappaB inhibitor pyrrolidine dithiocarbamate prevents cardiac remodelling and matrix metalloproteinase-2 up-regulation in renovascular hypertension. Basic Clin Pharmacol Toxicol 117:234\u2013241","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1906_CR5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.matbio.2012.01.009","volume":"31","author":"CS Ceron","year":"2012","unstructured":"Ceron CS, Rizzi E, Guimaraes DA, Martins-Oliveira A, Cau SB, Ramos J, Gerlach RF, Tanus-Santos JE (2012) Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension. Matrix Biol 31:261\u2013270","journal-title":"Matrix Biol"},{"key":"1906_CR6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejphar.2018.02.008","volume":"825","author":"CS Ceron","year":"2018","unstructured":"Ceron CS, do Vale GT, Simplicio JA, Ricci ST, De Martinis BS, de Freitas A, Tirapelli CR (2018) Chronic ethanol consumption increases vascular oxidative stress and the mortality induced by sub-lethal sepsis: potential role of iNOS. Eur J Pharmacol 825:39\u201347","journal-title":"Eur J Pharmacol"},{"key":"1906_CR7","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1742-7843.2010.00573.x","volume":"107","author":"M Chabicovsky","year":"2010","unstructured":"Chabicovsky M, Prieschl-Grassauer E, Seipelt J, Muster T, Szolar OH, Hebar A, Doblhoff-Dier O (2010) Pre-clinical safety evaluation of pyrrolidine dithiocarbamate. Basic Clin Pharmacol Toxicol 107:758\u2013767","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1906_CR8","first-page":"412","volume":"3","author":"F Chen","year":"2012","unstructured":"Chen F, Haigh S, Barman S, Fulton DJ (2012) From form to function: the role of Nox4 in the cardiovascular system. Front Physiol 3:412","journal-title":"Front Physiol"},{"key":"1906_CR9","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/ndt\/gfh441","volume":"19","author":"FY Chow","year":"2004","unstructured":"Chow FY, Nikolic-Paterson DJ, Atkins RC, Tesch GH (2004) Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis. Nephrol Dial Traspl 19:2987\u20132996","journal-title":"Nephrol Dial Traspl"},{"key":"1906_CR10","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.biocel.2007.12.006","volume":"40","author":"IM Clark","year":"2008","unstructured":"Clark IM, Swingler TE, Sampieri CL, Edwards DR (2008) The regulation of matrix metalloproteinases and their inhibitors. Int J Biochem Cell Biol 40:1362\u20131378","journal-title":"Int J Biochem Cell Biol"},{"key":"1906_CR11","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1080\/13880209.2017.1333127","volume":"55","author":"PA Dar","year":"2017","unstructured":"Dar PA, Ali F, Sheikh IA, Ganie SA, Dar TA (2017) Amelioration of hyperglycaemia and modulation of antioxidant status by Alcea rosea seeds in alloxan-induced diabetic rats. Pharm Biol 55:1849\u20131855","journal-title":"Pharm Biol"},{"key":"1906_CR12","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","volume":"11","author":"JD Dignam","year":"1983","unstructured":"Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475\u20131489","journal-title":"Nucleic Acids Res"},{"key":"1906_CR13","doi-asserted-by":"crossref","first-page":"6532637","DOI":"10.1155\/2018\/6532637","volume":"2018","author":"NN do Nascimento Kaut","year":"2018","unstructured":"do Nascimento Kaut NN, ACS R, Araujo GR, Taylor JG, Silva ME, Pedrosa ML, Chaves MM, Rossoni Junior JV, Costa DC (2018) Baccharis trimera (Carqueja) improves metabolic and redox status in an experimental model of type 1 diabetes. Evid Based Complement Alternat Med 2018:6532637","journal-title":"Evid Based Complement Alternat Med"},{"key":"1906_CR14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2017.01.036","volume":"799","author":"GT do Vale","year":"2017","unstructured":"do Vale GT, Gonzaga NA, Simplicio JA, Tirapelli CR (2017) Nebivolol prevents ethanol-induced reactive oxygen species generation and lipoperoxidation in the rat kidney by regulating NADPH oxidase activation and expression. Eur J Pharmacol 799:33\u201340","journal-title":"Eur J Pharmacol"},{"key":"1906_CR15","doi-asserted-by":"crossref","first-page":"F298","DOI":"10.1152\/ajprenal.90628.2008","volume":"296","author":"CM Elks","year":"2009","unstructured":"Elks CM, Mariappan N, Haque M, Guggilam A, Majid DS, Francis J (2009) Chronic NF-{kappa}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR. Am J Physiol Renal Physiol 296:F298\u2013F305","journal-title":"Am J Physiol Renal Physiol"},{"key":"1906_CR16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","volume":"23","author":"JL Evans","year":"2002","unstructured":"Evans JL, Goldfine ID, Maddux BA, Grodsky GM (2002) Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23:599\u2013622","journal-title":"Endocr Rev"},{"key":"1906_CR17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/2193-1801-3-283","volume":"3","author":"FA Garcia","year":"2014","unstructured":"Garcia FA, Pinto SF, Cavalcante AF, Lucetti LT, Menezes SM, Felipe CF, Alves AP, Brito GA, Cerqueira GS, Viana GS (2014) Pentoxifylline decreases glycemia levels and TNF-alpha, iNOS and COX-2 expressions in diabetic rat pancreas. Springerplus 3:283","journal-title":"Springerplus"},{"key":"1906_CR18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12950-015-0080-5","volume":"12","author":"FA Garcia","year":"2015","unstructured":"Garcia FA, Reboucas JF, Balbino TQ, da Silva TG, de Carvalho-Junior CH, Cerqueira GS, Brito GA, Viana GS (2015) Pentoxifylline reduces the inflammatory process in diabetic rats: relationship with decreases of pro-inflammatory cytokines and inducible nitric oxide synthase. J Inflamm (Lond) 12:33","journal-title":"J Inflamm (Lond)"},{"key":"1906_CR19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1139\/apnm-2017-0461","volume":"43","author":"M Gargouri","year":"2018","unstructured":"Gargouri M, Hamed H, Akrouti A, Dauvergne X, Magne C, El Feki A (2018) Effects of Spirulina platensis on lipid peroxidation, antioxidant defenses, and tissue damage in kidney of alloxan-induced diabetic rats. Appl Physiol Nutr Metab 43:345\u2013354","journal-title":"Appl Physiol Nutr Metab"},{"key":"1906_CR20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejphar.2014.10.021","volume":"744","author":"A Hofni","year":"2014","unstructured":"Hofni A, El-Moselhy MA, Taye A, Khalifa MM (2014) Combination therapy with spironolactone and candesartan protects against streptozotocin-induced diabetic nephropathy in rats. Eur J Pharmacol 744:173\u2013182","journal-title":"Eur J Pharmacol"},{"key":"1906_CR21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.bjp.0703603","volume":"131","author":"HJ Hong","year":"2000","unstructured":"Hong HJ, Loh SH, Yen MH (2000) Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase. Br J Pharmacol 131:631\u2013637","journal-title":"Br J Pharmacol"},{"key":"1906_CR22","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1681\/ASN.V1281630","volume":"12","author":"N Ishii","year":"2001","unstructured":"Ishii N, Patel KP, Lane PH, Taylor T, Bian K, Murad F, Pollock JS, Carmines PK (2001) Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus. J Am Soc Nephrol 12:1630\u20131639","journal-title":"J Am Soc Nephrol"},{"key":"1906_CR23","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1681\/ASN.2013070810","volume":"25","author":"JC Jha","year":"2014","unstructured":"Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA (2014) Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy. J Am Soc Nephrol 25:1237\u20131254","journal-title":"J Am Soc Nephrol"},{"key":"1906_CR24","doi-asserted-by":"crossref","unstructured":"Khan S, Jena G (2014) Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-beta1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 73:127\u2013139","DOI":"10.1016\/j.fct.2014.08.010"},{"key":"1906_CR25","doi-asserted-by":"crossref","unstructured":"Khan S, Jena G, Tikoo K, Kumar V (2015) Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-kappaB\/iNOS signaling in diabetic rat. Biochimie 110:1\u201316","DOI":"10.1016\/j.biochi.2014.12.015"},{"key":"1906_CR26","volume":"12","author":"SS Kim","year":"2017","unstructured":"Kim SS, Shin N, Bae SS, Lee MY, Rhee H, Kim IY, Seong EY, Lee DW, Lee SB, Kwak IS, Lovett DH, Song SH (2017) Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy. PLoS One 12:e0171625","journal-title":"PLoS One"},{"key":"1906_CR27","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1038\/s41440-019-0326-3","volume":"42","author":"S Kim","year":"2019","unstructured":"Kim S, Jo CH, Kim GH (2019) Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats. Hypertens Res 42:1905\u20131915","journal-title":"Hypertens Res"},{"key":"1906_CR28","doi-asserted-by":"crossref","first-page":"F1121","DOI":"10.1152\/ajprenal.00265.2002","volume":"284","author":"R Komers","year":"2003","unstructured":"Komers R, Anderson S (2003) Paradoxes of nitric oxide in the diabetic kidney. Am J Physiol Renal Physiol 284:F1121\u2013F1137","journal-title":"Am J Physiol Renal Physiol"},{"key":"1906_CR29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2017.03.024","volume":"804","author":"LN Leite","year":"2017","unstructured":"Leite LN, do Vale GT, Simplicio JA, De Martinis BS, Carneiro FS, Tirapelli CR (2017) Ethanol-induced erectile dysfunction and increased expression of pro-inflammatory proteins in the rat cavernosal smooth muscle are mediated by NADPH oxidase-derived reactive oxygen species. Eur J Pharmacol 804:82\u201393","journal-title":"Eur J Pharmacol"},{"key":"1906_CR30","doi-asserted-by":"crossref","first-page":"L559","DOI":"10.1152\/ajplung.00090.2010","volume":"299","author":"X Lu","year":"2010","unstructured":"Lu X, Murphy TC, Nanes MS, Hart CM (2010) PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol 299:L559\u2013L566","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1906_CR31","volume":"12","author":"CW Lu","year":"2017","unstructured":"Lu CW, Lin Y, Lei YP, Wang L, He ZM, Xiong Y (2017) Pyrrolidine dithiocarbamate ameliorates endothelial dysfunction in thoracic aorta of diabetic rats by preserving vascular DDAH activity. PLoS One 12:e0179908","journal-title":"PLoS One"},{"key":"1906_CR32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12933-015-0239-7","volume":"14","author":"H Luo","year":"2015","unstructured":"Luo H, Wang X, Wang J, Chen C, Wang N, Xu Z, Chen S, Zeng C (2015) Chronic NF-kappaB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats. Cardiovasc Diabetol 14:76","journal-title":"Cardiovasc Diabetol"},{"key":"1906_CR33","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3390\/jcm4061207","volume":"4","author":"A Martinez-Castelao","year":"2015","unstructured":"Martinez-Castelao A, Navarro-Gonzalez JF, Gorriz JL, de Alvaro F (2015) The concept and the epidemiology of diabetic nephropathy have changed in recent years. J Clin Med 4:1207\u20131216","journal-title":"J Clin Med"},{"key":"1906_CR34","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.bcp.2013.03.023","volume":"85","author":"MV Nguyen","year":"2013","unstructured":"Nguyen MV, Lardy B, Rousset F, Hazane-Puch F, Zhang L, Trocme C, Serrander L, Krause KH, Morel F (2013) Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4. Biochem Pharmacol 85:1644\u20131654","journal-title":"Biochem Pharmacol"},{"key":"1906_CR35","first-page":"11","volume":"3","author":"M Pourghasem","year":"2014","unstructured":"Pourghasem M, Nasiri E, Shafi H (2014) Early renal histological changes in alloxan-induced diabetic rats. Int J Mol Cell Med 3:11\u201315","journal-title":"Int J Mol Cell Med"},{"key":"1906_CR36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vascn.2015.11.004","volume":"78","author":"M Radenkovic","year":"2016","unstructured":"Radenkovic M, Stojanovic M, Prostran M (2016) Experimental diabetes induced by alloxan and streptozotocin: the current state of the art. J Pharmacol Toxicol Methods 78:13\u201331","journal-title":"J Pharmacol Toxicol Methods"},{"key":"1906_CR37","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","volume":"115","author":"R Radi","year":"2018","unstructured":"Radi R (2018) Oxygen radicals, nitric oxide, and peroxynitrite: redox pathways in molecular medicine. Proc Natl Acad Sci U S A 115:5839\u20135848","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1906_CR38","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.2741\/3467","volume":"14","author":"G Rangan","year":"2009","unstructured":"Rangan G, Wang Y, Harris D (2009) NF-kappaB signalling in chronic kidney disease. Front Biosci (Landmark Ed) 14:3496\u20133522","journal-title":"Front Biosci (Landmark Ed)"},{"key":"1906_CR39","doi-asserted-by":"crossref","first-page":"222","DOI":"10.23876\/j.krcp.2018.37.3.222","volume":"37","author":"H Rhee","year":"2018","unstructured":"Rhee H, Han M, Kim SS, Kim IY, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH (2018) The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease. Kidney Res Clin Pract 37:222\u2013229","journal-title":"Kidney Res Clin Pract"},{"key":"1906_CR40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1758-5996-4-5","volume":"4","author":"C Ribeiro","year":"2012","unstructured":"Ribeiro C, Cambri LT, Dalia RA, Araujo MB, Ghezzi AC, Moura LP, Araujo GG, Botezelli JD, Mello MA (2012) Muscle protein metabolism in neonatal alloxan-administered rats: effects of continuous and intermittent swimming training. Diabetol Metab Syndr 4:5","journal-title":"Diabetol Metab Syndr"},{"key":"1906_CR41","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.2337\/db06-0477","volume":"55","author":"H Schmid","year":"2006","unstructured":"Schmid H, Boucherot A, Yasuda Y, Henger A, Brunner B, Eichinger F, Nitsche A, Kiss E, Bleich M, Grone HJ, Nelson PJ, Schlondorff D, Cohen CD, Kretzler M, European Renal c DNABC (2006) Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes 55:2993\u20133003","journal-title":"Diabetes"},{"key":"1906_CR42","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s00467-010-1503-4","volume":"25","author":"HW Schnaper","year":"2010","unstructured":"Schnaper HW, Hubchak SC, Runyan CE, Browne JA, Finer G, Liu X, Hayashida T (2010) A conceptual framework for the molecular pathogenesis of progressive kidney disease. Pediatr Nephrol 25:2223\u20132230","journal-title":"Pediatr Nephrol"},{"key":"1906_CR43","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1681\/ASN.2012111112","volume":"24","author":"M Sedeek","year":"2013","unstructured":"Sedeek M, Nasrallah R, Touyz RM, Hebert RL (2013) NADPH oxidases, reactive oxygen species, and the kidney: friend and foe. J Am Soc Nephrol 24:1512\u20131518","journal-title":"J Am Soc Nephrol"},{"key":"1906_CR44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/BJ20061903","volume":"406","author":"L Serrander","year":"2007","unstructured":"Serrander L, Cartier L, Bedard K, Banfi B, Lardy B, Plastre O, Sienkiewicz A, Forro L, Schlegel W, Krause KH (2007) NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J 406:105\u2013114","journal-title":"Biochem J"},{"key":"1906_CR45","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/jphp.12931","volume":"70","author":"R Shukla","year":"2018","unstructured":"Shukla R, Banerjee S, Tripathi YB (2018) Pueraria tuberosa extract inhibits iNOS and IL-6 through suppression of PKC-alpha and NF-kB pathway in diabetes-induced nephropathy. J Pharm Pharmacol 70:1102\u20131112","journal-title":"J Pharm Pharmacol"},{"key":"1906_CR46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.vph.2015.06.015","volume":"73","author":"JA Simplicio","year":"2015","unstructured":"Simplicio JA, Resstel LB, Tirapelli DP, D'Orleans-Juste P, Tirapelli CR (2015) Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vasc Pharmacol 73:124\u2013137","journal-title":"Vasc Pharmacol"},{"key":"1906_CR47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00394-006-0632-9","volume":"46","author":"F Song","year":"2007","unstructured":"Song F, Qi X, Chen W, Jia W, Yao P, Nussler AK, Sun X, Liu L (2007) Effect of Momordica grosvenori on oxidative stress pathways in renal mitochondria of normal and alloxan-induced diabetic mice. Involvement of heme oxygenase-1. Eur J Nutr 46:61\u201369","journal-title":"Eur J Nutr"},{"key":"1906_CR48","doi-asserted-by":"crossref","unstructured":"Ta MH, Rao P, Korgaonkar M, Foster SF, Peduto A, Harris DC, Rangan GK (2014) Pyrrolidine dithiocarbamate reduces the progression of total kidney volume and cyst enlargement in experimental polycystic kidney disease. Physiol Rep 2 12:12196\u201312210.","DOI":"10.14814\/phy2.12196"},{"key":"1906_CR49","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1440-1681.2007.04729.x","volume":"34","author":"GH Tesch","year":"2007","unstructured":"Tesch GH (2007) Role of macrophages in complications of type 2 diabetes. Clin Exp Pharmacol Physiol 34:1016\u20131019","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1906_CR50","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/CS20090557","volume":"118","author":"K Van der Heiden","year":"2010","unstructured":"Van der Heiden K, Cuhlmann S, Luong le A, Zakkar M, Evans PC (2010) Role of nuclear factor kappaB in cardiovascular health and disease. Clin Sci 118:593\u2013605","journal-title":"Clin Sci"},{"key":"1906_CR51","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jphs.2018.08.005","volume":"137","author":"Z Wang","year":"2018","unstructured":"Wang Z, Zhang J, Wang L, Li W, Chen L, Li J, Zhao D, Zhang H, Guo X (2018) Glycine mitigates renal oxidative stress by suppressing Nox4 expression in rats with streptozotocin-induced diabetes. J Pharmacol Sci 137:387\u2013394","journal-title":"J Pharmacol Sci"},{"key":"1906_CR52","doi-asserted-by":"crossref","first-page":"e12727","DOI":"10.1111\/jfbc.12727","volume":"43","author":"X Wang","year":"2019","unstructured":"Wang X, Qin A, Xiao F, Olatunji OJ, Zhang S, Pan D, Han W, Wang D, Ni Y (2019) N(6) -(2-hydroxyethyl)-adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation. J Food Biochem 43:e12727","journal-title":"J Food Biochem"},{"key":"1906_CR53","doi-asserted-by":"crossref","first-page":"C213","DOI":"10.1152\/ajpcell.00227.2011","volume":"303","author":"CR Williams","year":"2012","unstructured":"Williams CR, Lu X, Sutliff RL, Hart CM (2012) Rosiglitazone attenuates NF-kappaB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells. Am J Physiol Cell Physiol 303:C213\u2013C223","journal-title":"Am J Physiol Cell Physiol"},{"key":"1906_CR54","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.freeradbiomed.2018.06.042","volume":"124","author":"Q Yang","year":"2018","unstructured":"Yang Q, Wu FR, Wang JN, Gao L, Jiang L, Li HD, Ma Q, Liu XQ, Wei B, Zhou L, Wen J, Ma TT, Li J, Meng XM (2018) Nox4 in renal diseases: an update. Free Radic Biol Med 124:466\u2013472","journal-title":"Free Radic Biol Med"},{"key":"1906_CR55","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.taap.2012.08.029","volume":"264","author":"A Yogi","year":"2012","unstructured":"Yogi A, Callera GE, Mecawi AS, Batalhao ME, Carnio EC, Antunes-Rodrigues J, Queiroz RH, Touyz RM, Tirapelli CR (2012) Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: a role for angiotensin type 1 receptor. Toxicol Appl Pharmacol 264:470\u2013478","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01906-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01906-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01906-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T03:31:49Z","timestamp":1722915109000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-020-01906-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1906"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-01906-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,21]]},"assertion":[{"value":"1 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}