{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:31:53Z","timestamp":1772890313996,"version":"3.50.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970735"],"award-info":[{"award-number":["81970735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY18H010003"],"award-info":[{"award-number":["LY18H010003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00210-020-01920-3","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T12:03:18Z","timestamp":1592913798000},"page":"391-399","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Interleukin-38 overexpression prevents bleomycin-induced mouse pulmonary fibrosis"],"prefix":"10.1007","volume":"394","author":[{"given":"Zhiwei","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianli","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-6964","authenticated-orcid":false,"given":"Mingcai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"1920_CR1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1289\/ehp.7616119","volume":"16","author":"IY Adamson","year":"1976","unstructured":"Adamson IY (1976) Pulmonary toxicity of bleomycin. Environ Health Perspect 16:119\u2013126","journal-title":"Environ Health Perspect"},{"key":"1920_CR2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","volume":"41","author":"T Ashcroft","year":"1988","unstructured":"Ashcroft T, Simpson JM, Timbrell V (1988) Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41:467\u2013470","journal-title":"J Clin Pathol"},{"key":"1920_CR3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1359-6101(03)00060-1","volume":"14","author":"SP Atamas","year":"2003","unstructured":"Atamas SP, White B (2003) Cytokine regulation of pulmonary fibrosis in scleroderma. Cytokine Growth Factor Rev 14:537\u2013550","journal-title":"Cytokine Growth Factor Rev"},{"key":"1920_CR4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1365-2249.2011.04468.x","volume":"166","author":"NP Barlo","year":"2011","unstructured":"Barlo NP, van Moorsel CH, Korthagen NM, Heron M, Rijkers GT, Ruven HJ, van den Bosch JM, Grutters JC (2011) Genetic variability in the IL1RN gene and the balance between interleukin (IL)-1 receptor agonist and IL-1beta in idiopathic pulmonary fibrosis. Clin Exp Immunol 166:346\u2013351","journal-title":"Clin Exp Immunol"},{"key":"1920_CR5","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1089\/107999001753289505","volume":"21","author":"JT Bensen","year":"2001","unstructured":"Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (2001) Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J Interf Cytokine Res 21:899\u2013904","journal-title":"J Interf Cytokine Res"},{"key":"1920_CR6","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/j.1460-2075.1996.tb00542.x","volume":"15","author":"R Beyaert","year":"1996","unstructured":"Beyaert R, Cuenda A, Vanden Berghe W, Plaisance S, Lee JC, Haegeman G, Cohen P, Fiers W (1996) The p38\/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J 15:1914\u20131923","journal-title":"EMBO J"},{"key":"1920_CR7","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/annrheumdis-2016-210630","volume":"76","author":"MA Boutet","year":"2017","unstructured":"Boutet MA, Najm A, Bart G, Brion R, Touchais S, Trichet V, Layrolle P, Gabay C, Palmer G, Blanchard F, Le Goff B (2017) IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis 76:1304\u20131312","journal-title":"Ann Rheum Dis"},{"key":"1920_CR8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1164\/ajrccm.149.3.8118632","volume":"149","author":"BD Car","year":"1994","unstructured":"Car BD, Meloni F, Luisetti M, Semenzato G, Gialdroni-Grassi G, Walz A (1994) Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med 149:655\u2013659","journal-title":"Am J Respir Crit Care Med"},{"key":"1920_CR9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.taap.2013.11.012","volume":"275","author":"Y Chen","year":"2014","unstructured":"Chen Y, Li C, Weng D, Song L, Tang W, Dai W, Yu Y, Liu F, Zhao M, Lu C, Chen J (2014) Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL\/6 mice. Toxicol Appl Pharmacol 275:62\u201372","journal-title":"Toxicol Appl Pharmacol"},{"key":"1920_CR10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.imbio.2016.10.012","volume":"222","author":"M Chu","year":"2017","unstructured":"Chu M, Tam LS, Zhu J, Jiao D, Liu H, Cai Z, Dong J, Kai Lam CW, Wong CK (2017) In vivo anti-inflammatory activities of novel cytokine IL-38 in Murphy Roths Large (MRL)\/lpr mice. Immunobiology 222:483\u2013493","journal-title":"Immunobiology"},{"key":"1920_CR11","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1021\/cr980449z","volume":"99","author":"CA Claussen","year":"1999","unstructured":"Claussen CA, Long EC (1999) Nucleic acid recognition by metal complexes of bleomycin. Chem Rev 99:2797\u20132816","journal-title":"Chem Rev"},{"key":"1920_CR12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.smim.2013.10.008","volume":"25","author":"CA Dinarello","year":"2013","unstructured":"Dinarello CA, van der Meer JW (2013) Treating inflammation by blocking interleukin-1 in humans. Semin Immunol 25:469\u2013484","journal-title":"Semin Immunol"},{"key":"1920_CR13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.intimp.2015.11.015","volume":"30","author":"Q Gao","year":"2016","unstructured":"Gao Q, Li Y, Pan X, Yuan X, Peng X, Li M (2016) Lentivirus expressing soluble ST2 alleviates bleomycin-induced pulmonary fibrosis in mice. Int Immunopharmacol 30:188\u2013193","journal-title":"Int Immunopharmacol"},{"key":"1920_CR14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cytogfr.2018.01.001","volume":"39","author":"T Garraud","year":"2018","unstructured":"Garraud T, Harel M, Boutet MA, Le Goff B, Blanchard F (2018) The enigmatic role of IL-38 in inflammatory diseases. Cytokine Growth Factor Rev 39:26\u201335","journal-title":"Cytokine Growth Factor Rev"},{"key":"1920_CR15","first-page":"3786","volume":"117","author":"P Gasse","year":"2007","unstructured":"Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I (2007) IL-1R1\/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117:3786\u20133799","journal-title":"J Clin Invest"},{"key":"1920_CR16","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1111\/jcmm.14902","volume":"24","author":"Y Ge","year":"2020","unstructured":"Ge Y, Huang M, Wu Y, Dong N, Yao YM (2020) Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4(+) CD25(+) regulatory T cells. J Cell Mol Med 24:2027\u20132039","journal-title":"J Cell Mol Med"},{"key":"1920_CR17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJMra003200","volume":"345","author":"TJ Gross","year":"2001","unstructured":"Gross TJ, Hunninghake GW (2001) Idiopathic pulmonary fibrosis. N Engl J Med 345:517\u2013525","journal-title":"N Engl J Med"},{"issue":"835\u2013846","key":"1920_CR18","doi-asserted-by":"crossref","first-page":"e835","DOI":"10.1016\/j.celrep.2019.03.082","volume":"27","author":"Y Han","year":"2019","unstructured":"Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brune B, Weigert A (2019) IL-38 ameliorates skin inflammation and limits IL-17 production from gammadelta T cells. Cell Rep 27(835\u2013846):e835","journal-title":"Cell Rep"},{"key":"1920_CR19","first-page":"366","volume":"30","author":"C Huang","year":"2014","unstructured":"Huang C, Li Y, Fan X, Ma Y, Zhang M, Wang W (2014) IL-17A promotes pulmonary inflammation in rats with pulmonary fibrosis induced by bleomycin. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:366\u2013370","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"issue":"507\u2013511","key":"1920_CR20","first-page":"514","volume":"44","author":"RH Hubner","year":"2008","unstructured":"Hubner RH, Gitter W, El Mokhtari NE, Mathiak M, Both M, Bolte H, Freitag-Wolf S, Bewig B (2008) Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques 44(507\u2013511):514\u2013507","journal-title":"Biotechniques"},{"key":"1920_CR21","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1183\/09031936.00143708","volume":"34","author":"T Izumo","year":"2009","unstructured":"Izumo T, Kondo M, Nagai A (2009) Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis. Eur Respir J 34:1444\u20131451","journal-title":"Eur Respir J"},{"key":"1920_CR22","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI12568","volume":"107","author":"M Kolb","year":"2001","unstructured":"Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J (2001) Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 107:1529\u20131536","journal-title":"J Clin Invest"},{"key":"1920_CR23","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1007\/s10753-018-0820-9","volume":"41","author":"Y Li","year":"2018","unstructured":"Li Y, Gao Q, Xu K, Peng X, Yuan X, Jiang W, Li M (2018) Interleukin-37 attenuates bleomycin-induced pulmonary inflammation and fibrosis in mice. Inflammation 41:1772\u20131779","journal-title":"Inflammation"},{"key":"1920_CR24","doi-asserted-by":"crossref","first-page":"20597","DOI":"10.1074\/jbc.M010095200","volume":"276","author":"H Lin","year":"2001","unstructured":"Lin H, Ho AS, Haley-Vicente D, Zhang J, Bernal-Fussell J, Pace AM, Hansen D, Schweighofer K, Mize NK, Ford JE (2001) Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J Biol Chem 276:20597\u201320602","journal-title":"J Biol Chem"},{"key":"1920_CR25","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.4049\/jimmunol.153.8.3708","volume":"153","author":"Y Luo","year":"1994","unstructured":"Luo Y, Laning J, Hayashi M, Hancock PR, Rollins B, Dorf ME (1994) Serologic analysis of the mouse beta chemokine JE\/monocyte chemoattractant protein-1. J Immunol 153:3708\u20133716","journal-title":"J Immunol"},{"key":"1920_CR26","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1183\/09031936.00205009","volume":"37","author":"T Maron-Gutierrez","year":"2011","unstructured":"Maron-Gutierrez T, Castiglione RC, Xisto DG, Oliveira MG, Cruz FF, Pecanha R, Carreira-Junior H, Ornellas DS, Moraes MO, Takiya CM, Rocco PR, Morales MM (2011) Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis. Eur Respir J 37:1217\u20131225","journal-title":"Eur Respir J"},{"key":"1920_CR27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2739\/kurumemedj.MS652009","volume":"65","author":"M Matsuoka","year":"2019","unstructured":"Matsuoka M, Kawayama T, Tominaga M, Kaieda S, Tokunaga Y, Kaku Y, Imaoka H, Kinoshita T, Okamoto M, Akiba J, Hoshino T (2019) Attenuated airway eosinophilic inflammations in IL-38 knockout mouse model. Kurume Med J 65:37\u201346","journal-title":"Kurume Med J"},{"key":"1920_CR28","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/s41419-018-1143-3","volume":"9","author":"L Mercurio","year":"2018","unstructured":"Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, Dinarello CA, Albanesi C, Madonna S (2018) IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment. Cell Death Dis 9:1104","journal-title":"Cell Death Dis"},{"key":"1920_CR29","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.4049\/jimmunol.1004081","volume":"187","author":"S Mi","year":"2011","unstructured":"Mi S, Li Z, Yang HZ, Liu H, Wang JP, Ma YG, Wang XX, Liu HZ, Sun W, Hu ZW (2011) Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. J Immunol 187:3003\u20133014","journal-title":"J Immunol"},{"key":"1920_CR30","doi-asserted-by":"crossref","first-page":"L152","DOI":"10.1152\/ajplung.00313.2007","volume":"294","author":"BB Moore","year":"2008","unstructured":"Moore BB, Hogaboam CM (2008) Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294:L152\u2013L160","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1920_CR31","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.4049\/jimmunol.167.8.4368","volume":"167","author":"BB Moore","year":"2001","unstructured":"Moore BB, Paine R 3rd, Christensen PJ, Moore TA, Sitterding S, Ngan R, Wilke CA, Kuziel WA, Toews GB (2001) Protection from pulmonary fibrosis in the absence of CCR2 signaling. J Immunol 167:4368\u20134377","journal-title":"J Immunol"},{"key":"1920_CR32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI6094","volume":"104","author":"A Nakao","year":"1999","unstructured":"Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K, Iwamoto I (1999) Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 104:5\u201311","journal-title":"J Clin Invest"},{"key":"1920_CR33","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/emmm.201100604","volume":"4","author":"RJ O'Donoghue","year":"2012","unstructured":"O'Donoghue RJ, Knight DA, Richards CD, Prele CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE (2012) Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. EMBO Mol Med 4:939\u2013951","journal-title":"EMBO Mol Med"},{"key":"1920_CR34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cytogfr.2012.04.003","volume":"23","author":"S O'Reilly","year":"2012","unstructured":"O'Reilly S, Ciechomska M, Cant R, Hugle T, van Laar JM (2012) Interleukin-6, its role in fibrosing conditions. Cytokine Growth Factor Rev 23:99\u2013107","journal-title":"Cytokine Growth Factor Rev"},{"key":"1920_CR35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1165\/ajrcmb.20.4.3193","volume":"20","author":"LA Ortiz","year":"1999","unstructured":"Ortiz LA, Lasky J, Lungarella G, Cavarra E, Martorana P, Banks WA, Peschon JJ, Schmidts HL, Brody AR, Friedman M (1999) Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am J Respir Cell Mol Biol 20:825\u2013833","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1920_CR36","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.biopha.2018.12.028","volume":"110","author":"X Pan","year":"2019","unstructured":"Pan X, Xu K, Li Y, Wang X, Peng X, Li M, Li Y (2019) Interleukin-35 expression protects against cigarette smoke-induced lung inflammation in mice. Biomed Pharmacother 110:727\u2013732","journal-title":"Biomed Pharmacother"},{"key":"1920_CR37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/01902149209020649","volume":"18","author":"SH Phan","year":"1992","unstructured":"Phan SH, Kunkel SL (1992) Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res 18:29\u201343","journal-title":"Exp Lung Res"},{"key":"1920_CR38","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1183\/09031936.94.07030515","volume":"7","author":"PF Piguet","year":"1994","unstructured":"Piguet PF, Vesin C (1994) Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J 7:515\u2013518","journal-title":"Eur Respir J"},{"key":"1920_CR39","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.170.3.655","volume":"170","author":"PF Piguet","year":"1989","unstructured":"Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassalli P (1989) Tumor necrosis factor\/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 170:655\u2013663","journal-title":"J Exp Med"},{"key":"1920_CR40","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1002\/art.39328","volume":"67","author":"I Rudloff","year":"2015","unstructured":"Rudloff I, Godsell J, Nold-Petry CA, Harris J, Hoi A, Morand EF, Nold MF (2015) Brief report: Interleukin-38 exerts antiinflammatory functions and is associated with disease activity in systemic lupus erythematosus. Arthritis Rheumatol 67:3219\u20133225","journal-title":"Arthritis Rheumatol"},{"key":"1920_CR41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1165\/rcmb.2007-0299OC","volume":"38","author":"F Saito","year":"2008","unstructured":"Saito F, Tasaka S, Inoue K, Miyamoto K, Nakano Y, Ogawa Y, Yamada W, Shiraishi Y, Hasegawa N, Fujishima S, Takano H, Ishizaka A (2008) Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice. Am J Respir Cell Mol Biol 38:566\u2013571","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1920_CR42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1513\/pats.200601-008AW","volume":"3","author":"D Sheppard","year":"2006","unstructured":"Sheppard D (2006) Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 3:413\u2013417","journal-title":"Proc Am Thorac Soc"},{"key":"1920_CR43","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1378\/chest.120.2.617","volume":"120","author":"S Sleijfer","year":"2001","unstructured":"Sleijfer S (2001) Bleomycin-induced pneumonitis. Chest 120:617\u2013624","journal-title":"Chest"},{"key":"1920_CR44","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1034\/j.1399-3003.1999.14b23.x","volume":"14","author":"M Suga","year":"1999","unstructured":"Suga M, Iyonaga K, Ichiyasu H, Saita N, Yamasaki H, Ando M (1999) Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases. Eur Respir J 14:376\u2013382","journal-title":"Eur Respir J"},{"key":"1920_CR45","doi-asserted-by":"crossref","unstructured":"Sun X, Hou T, Cheung E, Iu TN, Tam VW, Chu IM, Tsang MS, Chan PK, Lam CW, Wong CK (2019) Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma. Cell Mol Immunol","DOI":"10.1038\/s41423-019-0300-7"},{"key":"1920_CR46","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/thoraxjnl-2013-203307","volume":"68","author":"HL Tan","year":"2013","unstructured":"Tan HL, Rosenthal M (2013) IL-17 in lung disease: friend or foe? Thorax 68:788\u2013790","journal-title":"Thorax"},{"key":"1920_CR47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1755-1536-5-11","volume":"5","author":"NW Todd","year":"2012","unstructured":"Todd NW, Luzina IG, Atamas SP (2012) Molecular and cellular mechanisms of pulmonary fibrosis. Fibrogenesis Tissue Repair 5:11","journal-title":"Fibrogenesis Tissue Repair"},{"key":"1920_CR48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.resinv.2017.06.001","volume":"55","author":"M Tominaga","year":"2017","unstructured":"Tominaga M, Okamoto M, Kawayama T, Matsuoka M, Kaieda S, Sakazaki Y, Kinoshita T, Mori D, Inoue A, Hoshino T (2017) Overexpression of IL-38 protein in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. Respir Investig 55:293\u2013299","journal-title":"Respir Investig"},{"key":"1920_CR49","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1073\/pnas.1121534109","volume":"109","author":"FL van de Veerdonk","year":"2012","unstructured":"van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, van der Meer JW, Hao R, Kalabokis V, Dinarello CA (2012) IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A 109:3001\u20133005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1920_CR50","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/thx.54.9.805","volume":"54","author":"Q Wang","year":"1999","unstructured":"Wang Q, Wang Y, Hyde DM, Gotwals PJ, Koteliansky VE, Ryan ST, Giri SN (1999) Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters. Thorax 54:805\u2013812","journal-title":"Thorax"},{"key":"1920_CR51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/mi.2008.85","volume":"2","author":"MS Wilson","year":"2009","unstructured":"Wilson MS, Wynn TA (2009) Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol 2:103\u2013121","journal-title":"Mucosal Immunol"},{"key":"1920_CR52","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20092121","volume":"207","author":"MS Wilson","year":"2010","unstructured":"Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA (2010) Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207:535\u2013552","journal-title":"J Exp Med"},{"key":"1920_CR53","doi-asserted-by":"crossref","first-page":"154963","DOI":"10.1016\/j.cyto.2019.154963","volume":"127","author":"C Xie","year":"2020","unstructured":"Xie C, Yan W, Quan R, Chen C, Tu L, Hou X, Fu Y (2020) Interleukin-38 is elevated in inflammatory bowel diseases and suppresses intestinal inflammation. Cytokine 127:154963","journal-title":"Cytokine"},{"key":"1920_CR54","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/infdis\/jiy289","volume":"218","author":"F Xu","year":"2018","unstructured":"Xu F, Lin S, Yan X, Wang C, Tu H, Yin Y, Cao J (2018) Interleukin 38 protects against lethal sepsis. J Infect Dis 218:1175\u20131184","journal-title":"J Infect Dis"},{"key":"1920_CR55","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbrc.2018.11.114","volume":"508","author":"K Xu","year":"2019","unstructured":"Xu K, Sun J, Chen S, Li Y, Peng X, Li M, Li Y (2019) Hydrodynamic delivery of IL-38 gene alleviates obesity-induced inflammation and insulin resistance. Biochem Biophys Res Commun 508:198\u2013202","journal-title":"Biochem Biophys Res Commun"},{"key":"1920_CR56","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.intimp.2016.09.023","volume":"40","author":"X Yuan","year":"2016","unstructured":"Yuan X, Li Y, Pan X, Peng X, Song G, Jiang W, Gao Q, Li M (2016) IL-38 alleviates concanavalin A-induced liver injury in mice. Int Immunopharmacol 40:452\u2013457","journal-title":"Int Immunopharmacol"},{"key":"1920_CR57","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.4049\/jimmunol.150.9.4188","volume":"150","author":"Y Zhang","year":"1993","unstructured":"Zhang Y, Lee TC, Guillemin B, Yu MC, Rom WN (1993) Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J Immunol 150:4188\u20134196","journal-title":"J Immunol"},{"key":"1920_CR58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1465-9921-11-34","volume":"11","author":"Y Zhu","year":"2010","unstructured":"Zhu Y, Liu Y, Zhou W, Xiang R, Jiang L, Huang K, Xiao Y, Guo Z, Gao J (2010) A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice. Respir Res 11:34","journal-title":"Respir Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01920-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01920-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01920-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:43:08Z","timestamp":1696279388000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-020-01920-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,23]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["1920"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-01920-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,23]]},"assertion":[{"value":"19 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal procedures were in accordance with the Guide for the Care and Use of Laboratory Animals (8th edition, NIH) and approved by The Laboratory Animal Ethics Committee of Ningbo University School of Medicine.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}