{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:22:36Z","timestamp":1773199356292,"version":"3.50.1"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["207111\/2014-6"],"award-info":[{"award-number":["207111\/2014-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303247\/2019-3"],"award-info":[{"award-number":["303247\/2019-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00210-020-01943-w","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T09:02:50Z","timestamp":1594458170000},"page":"2301-2314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders"],"prefix":"10.1007","volume":"393","author":[{"given":"Antonia Amanda Cardoso de","family":"Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto de Oliveira","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rusbene Bruno Fonseca","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia dos Santos","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano da Silva","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalton","family":"Dittz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Marcelo de","family":"Castro e Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-6497","authenticated-orcid":false,"given":"Paulo Michel Pinheiro","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"1943_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.brainres.2012.01.070","volume":"1448","author":"AAC Almeida","year":"2012","unstructured":"Almeida AAC, Costa JP, Carvalho RBF, Sousa DP, Freitas RM (2012) Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action. Brain Res 1448:56\u201362. https:\/\/doi.org\/10.1016\/j.brainres.2012.01.070","journal-title":"Brain Res"},{"key":"1943_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.pbb.2014.01.006","volume":"118","author":"AAC Almeida","year":"2014","unstructured":"Almeida AAC, Carvalho RBF, Silva OA, Sousa DP, Freitas RM (2014a) Potential antioxidant and anxiolytic effects of (+)-limonene epoxide in mice after marble-burying test. Pharmacol Biochem Behav 118:69\u201378. https:\/\/doi.org\/10.1016\/j.pbb.2014.01.006","journal-title":"Pharmacol Biochem Behav"},{"key":"1943_CR3","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.brainres.2012.01.070","volume":"19","author":"AAC Almeida","year":"2014","unstructured":"Almeida AAC, Carvalho RBF, Sousa DP, Souza GF, Oliveira JS, Freitas RM (2014b) Evaluation of acute toxicity the (+)-limonene epoxide in adult mice. Rev Cubana Plant Med 19:160\u2013171. https:\/\/doi.org\/10.1016\/j.brainres.2012.01.070","journal-title":"Rev Cubana Plant Med"},{"key":"1943_CR4","first-page":"99","volume":"51","author":"S Alvarado-Rico","year":"2010","unstructured":"Alvarado-Rico S, Castro L (2010) Histologia del h\u00edgado das ratas tratadas con una infusi\u00f3n de hojas de higuera (Ficus carica). Rev Cient Eletr Med Vet 51:99\u2013103 http:\/\/saber.ucv.ve\/ojs\/index.php\/revisfcv\/article\/view\/15617\/144814482280","journal-title":"Rev Cient Eletr Med Vet"},{"key":"1943_CR5","first-page":"11","volume":"35","author":"HZ Amenya","year":"2011","unstructured":"Amenya HZ, Thoithi GN, Thaiyah AG, Mbaria JM, Gahtumbi PK (2011) In vitro and acute in vivo toxicity and of aqueous and chloroformic extracts of Rapanea melanophloeos (L.) Mez in brine shrimp and Sprague Dawley rats. Kenya Veterinarian 35:11\u201318 https:\/\/www.ajol.info\/index.php\/kenvet\/article\/view\/87551","journal-title":"Kenya Veterinarian"},{"key":"1943_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.pnpbp.2014.10.009","volume":"57","author":"L Antkiewicz-Michaluk","year":"2015","unstructured":"Antkiewicz-Michaluk L, W\u0105sik A, Mo\u017cd\u017ce\u0144 E, Roma\u0144ska I, Michaluk J (2015) Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Prog Neuro-Psychopharmacol Biol Psychiatry 57:146\u2013154. https:\/\/doi.org\/10.1016\/j.pnpbp.2014.10.009","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"1943_CR7","unstructured":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (ANVISA) (2013) Guia para a condu\u00e7\u00e3o de estudos n\u00e3o cl\u00ednicos de toxicologia e seguran\u00e7a farmacol\u00f3gica necess\u00e1ria ao desenvolvimento de medicamentos.http:\/\/portal.anvisa.gov.br\/resultado-de busca?p_p_id=101&p_p_lifecycle=0& p_p_state=maximized&p_p_mode=view&p_p_col_id=column1&p_p_col_count=1&_101_struts_action=%2Fasset_publisher%2Fview_content&_101_assetEntryId=3274317&_101_type=document. (acessed 15 april 2017)"},{"key":"1943_CR8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.jep.2017.01.006","volume":"198","author":"EJF Ara\u00fajo","year":"2017","unstructured":"Ara\u00fajo EJF, Almeida AAC, Silva AO et al (2017) Behavioral effects induced by antitumor clerodane diterpenes from Casearia sylvestris and in silico interactions with neuron receptors. J Ethnopharmacol 198:460\u2013467. https:\/\/doi.org\/10.1016\/j.jep.2017.01.006","journal-title":"J Ethnopharmacol"},{"key":"1943_CR9","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.biopha.2018.04.130","volume":"103","author":"EJF Ara\u00fajo","year":"2018","unstructured":"Ara\u00fajo EJF, Rezende Junior LM, Lima LKF et al (2018) Pathophysiological investigations, anxiolytic effects and interaction of a semisynthetic riparin with benzodiazepine receptors. Biomed Pharmacother 103:973\u2013981. https:\/\/doi.org\/10.1016\/j.biopha.2018.04.130","journal-title":"Biomed Pharmacother"},{"key":"1943_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.fct.2012.11.021","volume":"52","author":"B Bakoma","year":"2013","unstructured":"Bakoma B, Berk\u00e9rb B, Eklu-Gadegbekua K, Agbonona A, Aklikokoua K, Gbeassora M, Creppyc EE, Mooreb N (2013) Acute and sub-chronic (28 days) oral toxicity evaluation of hydroethanolic extract of Bridelia ferruginea Benth root bark in male rodent animals. Food Chem Toxicol 52:176\u2013179. https:\/\/doi.org\/10.1016\/j.fct.2012.11.021","journal-title":"Food Chem Toxicol"},{"key":"1943_CR11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.pbb.2019.06.006","volume":"183","author":"SR Bampi","year":"2019","unstructured":"Bampi SR, Casaril AM, Sabedra Sousa FS, Pesarico AP, Vieira B, Lenard\u00e3o EJ, Savegnago L (2019) Repeated administration of a selenium-containing indolyl compound attenuates behavioural alterations by streptozotocin through modulation of oxidative stress in mice. Pharmacol Biochem Behav 183:46\u201355. https:\/\/doi.org\/10.1016\/j.pbb.2019.06.006","journal-title":"Pharmacol Biochem Behav"},{"key":"1943_CR12","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.pharep.2016.06.011","volume":"68","author":"B Blaszczyk","year":"2016","unstructured":"Blaszczyk B, Czuczwar SJ (2016) Epilepsy coexisting with depression. Pharmacol Rep 68:1084\u20131092. https:\/\/doi.org\/10.1016\/j.pharep.2016.06.011","journal-title":"Pharmacol Rep"},{"key":"1943_CR13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.neulet.2011.02.010","volume":"497","author":"H Blumenfeld","year":"2011","unstructured":"Blumenfeld H (2011) New strategies for preventing epileptogenesis: perspective and overview. Neurosci Lett 497:153\u2013154. https:\/\/doi.org\/10.1016\/j.neulet.2011.02.010","journal-title":"Neurosci Lett"},{"key":"1943_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.4034\/RBCS\/2011.15.02.11","volume":"15","author":"ACSC Branco","year":"2011","unstructured":"Branco ACSC, Diniz MFFM, Almeida RN, Santos HB, De Oliveira KM, Ramalho JA, Dantas JG (2011) Biochemical and hematological parameters of Wistar rats and swiss mice in the professor Thomas George animal laboratory. Rev Bras Cienc Sa\u00fade 15:209\u2013214. https:\/\/doi.org\/10.4034\/RBCS\/2011.15.02.11","journal-title":"Rev Bras Cienc Sa\u00fade"},{"key":"1943_CR15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/01480540500262763","volume":"28","author":"R Brand\u00e3o","year":"2005","unstructured":"Brand\u00e3o R, Lara FS, Pagliosa LB, Soares FA, Rocha JB, Nogueira CW, Farina M (2005) Hemolytic effects of sodium selenite and mercuric chloride in human blood. Drug Chem Toxicol 28:397\u2013407. https:\/\/doi.org\/10.1080\/01480540500262763","journal-title":"Drug Chem Toxicol"},{"key":"1943_CR16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/s0378-8741(01)00192-1","volume":"76","author":"EN Bum","year":"2001","unstructured":"Bum EN, Schmutz M, Meyer C, Rakotonirina A, Bopelet M, Portet C, Jeker A, Rakotonirina SV, Olpe HR, Herrling P (2001) Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae). J Ethnopharmacol 76:145\u2013150. https:\/\/doi.org\/10.1016\/s0378-8741(01)00192-1","journal-title":"J Ethnopharmacol"},{"key":"1943_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1021\/cn5000056","volume":"5","author":"NE Calcaterra","year":"2014","unstructured":"Calcaterra NE, Barrow JC (2014) Classics in chemical neuroscience: diazepam (valium). ACS Chem Neurosci 5:253\u2013260. https:\/\/doi.org\/10.1021\/cn5000056","journal-title":"ACS Chem Neurosci"},{"key":"1943_CR18","doi-asserted-by":"publisher","first-page":"e3769","DOI":"10.3791\/3769","volume":"59","author":"A Can","year":"2012","unstructured":"Can A, Dao DT, Terrillion CE, Piantadosi SC, Bhat S, Gould TD (2012) The tail suspension test. J Vis Exp 59:e3769. https:\/\/doi.org\/10.3791\/3769","journal-title":"J Vis Exp"},{"key":"1943_CR19","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1177\/0269881117725915","volume":"9","author":"RL Carhart-Harris","year":"2017","unstructured":"Carhart-Harris RL, Nutt DJ (2017) Serotonin and brain function: a tale of two receptors. J Psychopharmacol 9:1091\u20131120. https:\/\/doi.org\/10.1177\/0269881117725915","journal-title":"J Psychopharmacol"},{"key":"1943_CR20","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.5897\/AJPP2013.3598","volume":"7","author":"CC Carvalho","year":"2013","unstructured":"Carvalho CC, Machado KN, Ferreira PMP, Pessoa C, Fonseca THS, Gomes MA, Nascimento AM (2013) Biological screening of extracts of Brazilian Asteraceae plants. Afr J Pharm Pharmacol 7:2000\u20132005. https:\/\/doi.org\/10.5897\/AJPP2013.3598","journal-title":"Afr J Pharm Pharmacol"},{"key":"1943_CR21","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1590\/0001-3765201620150553","volume":"88","author":"FRS Carvalho","year":"2016","unstructured":"Carvalho FRS, Moura AG, Rodrigues GF et al (2016) Are salty liquid food flavorings in vitro antitumor substances? An Acad Bras Cienc 88:1419\u20131430. https:\/\/doi.org\/10.1590\/0001-3765201620150553","journal-title":"An Acad Bras Cienc"},{"key":"1943_CR22","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4034\/RBCS.2012.16.03.04","volume":"3","author":"DA Costa","year":"2012","unstructured":"Costa DA, Oliveira GAL, Costa JP, Souza GF, Sousa DP, Freitas RM (2012) Evaluation of acute toxicity and anxiolytic effect of a synthetic derivative of carvone. Rev Bras Cienc Sa\u00fade 3:303\u2013310. https:\/\/doi.org\/10.4034\/RBCS.2012.16.03.04","journal-title":"Rev Bras Cienc Sa\u00fade"},{"key":"1943_CR23","first-page":"357","volume":"3","author":"LC Cunha","year":"2013","unstructured":"Cunha LC, Melo DFA, Pereira ME et al (2013) Assessment of acute toxicity of water extract from Apeiba tibourbou Aubl (Tiliaceae) in mice and rats. Rev Cienc Farm B\u00e1sica Apl 3:357\u2013362","journal-title":"Rev Cienc Farm B\u00e1sica Apl"},{"key":"1943_CR24","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1590\/S0100-40422001000600004","volume":"6","author":"JP David","year":"2001","unstructured":"David JP, Silva EF, Moura DL, Guedes MLS, Assun\u00e7\u00e3o RJ, David JM (2001) Lignans and triterpenes from cytotoxic extract of Eriope blanchetii. Quim Nova 6:730\u2013733. https:\/\/doi.org\/10.1590\/S0100-40422001000600004","journal-title":"Quim Nova"},{"key":"1943_CR25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.phrs.2016.01.021","volume":"112","author":"RC Dutra","year":"2016","unstructured":"Dutra RC, Campos MM, Santos ARS, Calixto JB (2016) Medicinal plants in Brazil: pharmacological studies, drug discovery, challenges and perspectives. Pharm Res 112:4\u201329. https:\/\/doi.org\/10.1016\/j.phrs.2016.01.021","journal-title":"Pharm Res"},{"key":"1943_CR26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cca.2014.10.031","volume":"30","author":"M Emdin","year":"2015","unstructured":"Emdin M, Fatini C, Mirizzi G, Poletti R, Borrelli C, Prontera C, Latini R, Passino C, Clerico A, Vergaro G (2015) Biomarkers of activation of renin-angiotensin-aldosterone system in heart failure: how useful, how feasible? Clin Chim Acta 30:85\u201393. https:\/\/doi.org\/10.1016\/j.cca.2014.10.031","journal-title":"Clin Chim Acta"},{"key":"1943_CR27","doi-asserted-by":"publisher","first-page":"e16076","DOI":"10.1590\/s2175-97902017000216076","volume":"53","author":"PMP Ferreira","year":"2017","unstructured":"Ferreira PMP, Pessoa C (2017) Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challenges. Braz J Pharm Sci 53:e16076. https:\/\/doi.org\/10.1590\/s2175-97902017000216076","journal-title":"Braz J Pharm Sci"},{"key":"1943_CR28","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1590\/0001-3765201520130345","volume":"87","author":"PMP Ferreira","year":"2015","unstructured":"Ferreira PMP, Costa PM, Costa AM et al (2015) Cytotoxic and toxicological effects of phthalimide derivatives on tumor and normal murine cells. An Acad Bras Cienc 87:313\u2013330. https:\/\/doi.org\/10.1590\/0001-3765201520130345","journal-title":"An Acad Bras Cienc"},{"key":"1943_CR29","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jep.2016.04.011","volume":"186","author":"PMP Ferreira","year":"2016","unstructured":"Ferreira PMP, Bezerra DP, Silva JN et al (2016) Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and its component Casearin X: in vivo and ex vivo methods and microscopy examinations. J Ethnopharmacol 186:270\u2013279. https:\/\/doi.org\/10.1016\/j.jep.2016.04.011","journal-title":"J Ethnopharmacol"},{"key":"1943_CR30","doi-asserted-by":"publisher","first-page":"112004","DOI":"10.1016\/j.jep.2019.112004","volume":"241","author":"PMP Ferreira","year":"2019","unstructured":"Ferreira PMP, Santos DB, Silva JN et al (2019) Toxicological findings about an anticancer fraction with casearins described by traditional and alternative techniques as support to the Brazilian Unified Health System (SUS). J Ethnopharmacol 241:112004. https:\/\/doi.org\/10.1016\/j.jep.2019.112004","journal-title":"J Ethnopharmacol"},{"key":"1943_CR31","volume-title":"Statistics for toxicologists. In Principles and methods in toxicology","author":"S Gad","year":"2014","unstructured":"Gad S (2014) Statistics for toxicologists. In Principles and methods in toxicology. Taylor & Francis Group, Philadelphia"},{"key":"1943_CR32","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbr.2012.10.015","volume":"238","author":"S Gao","year":"2013","unstructured":"Gao S, Cui YL, Yua CQ, Wang QS, Zhang Y (2013) Tetrandrine exerts antidepressant-like effects in animal models: role of brain-derived neurotrophic fator. Behav Brain Res 238:79\u201385. https:\/\/doi.org\/10.1016\/j.bbr.2012.10.015","journal-title":"Behav Brain Res"},{"key":"1943_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/212964","volume":"2015","author":"AL Gomes-J\u00fanior","year":"2015","unstructured":"Gomes-J\u00fanior AL, Paz MF, Silva LI et al (2015) Serum oxidative stress markers and genotoxic profile induced by chemotherapy in patients with breast cancer: a pilot study. Oxidative Med Cell Longev 2015:1\u201311. https:\/\/doi.org\/10.1155\/2015\/212964","journal-title":"Oxidative Med Cell Longev"},{"key":"1943_CR34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.lfs.2015.02.021","volume":"128","author":"SL Guzm\u00e1n-Guti\u00e9rrez","year":"2015","unstructured":"Guzm\u00e1n-Guti\u00e9rrez SL, Bonilla-Jaime H, G\u00f3mez-Cansino R, Reyes-Chilp R (2015) Linalool and \u03b2-pinene exert their antidepressant-like activity through the monoaminergic pathway. Life Sci 128:24\u201329. https:\/\/doi.org\/10.1016\/j.lfs.2015.02.021","journal-title":"Life Sci"},{"key":"1943_CR35","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.foodres.2015.07.027","volume":"76","author":"S Hall","year":"2015","unstructured":"Hall S, Desbrow B, Anoopkumar-Dukie S, Davey AK, Arora D, McDermott C, Schubert MM, Perkins AV, Kiefel MJ, Grant GD (2015) A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression. Food Res Int 76:626\u2013636. https:\/\/doi.org\/10.1016\/j.foodres.2015.07.027","journal-title":"Food Res Int"},{"key":"1943_CR36","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1021\/es60130a004","volume":"12","author":"MA Hamilton","year":"1977","unstructured":"Hamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 12:714\u2013719. https:\/\/doi.org\/10.1021\/es60130a004","journal-title":"Environ Sci Technol"},{"key":"1943_CR37","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.phymed.2010.10.001","volume":"18","author":"AT Hariri","year":"2011","unstructured":"Hariri AT, Moallem SA, Mahmoudi M, Hosseinzadeh H (2011) The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomed 18:499\u2013504. https:\/\/doi.org\/10.1016\/j.phymed.2010.10.001","journal-title":"Phytomed"},{"key":"1943_CR38","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.toxicon.2014.10.020","volume":"92","author":"AL Harvey","year":"2014","unstructured":"Harvey AL (2014) Toxins and drug discovery. Toxicon 92:193\u2013200. https:\/\/doi.org\/10.1016\/j.toxicon.2014.10.020","journal-title":"Toxicon"},{"key":"1943_CR39","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.taap.2007.10.022","volume":"277","author":"KA Houck","year":"2008","unstructured":"Houck KA, Kavlock RJ (2008) Understanding mechanisms of toxicity: insights from drug discovery research. Toxicol Appl Pharmacol 277:163\u2013178. https:\/\/doi.org\/10.1016\/j.taap.2007.10.022","journal-title":"Toxicol Appl Pharmacol"},{"key":"1943_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3823\/2059","volume":"9","author":"T Islam","year":"2016","unstructured":"Islam T, Santos JVO, Ferreira JRO et al (2016) A possible phytol-cytoprotective trait through reactive species-induced oxidative stress ebbing pathway. Int Arch Med 9:1\u201311. https:\/\/doi.org\/10.3823\/2059","journal-title":"Int Arch Med"},{"key":"1943_CR41","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jcis.2014.05.060","volume":"431","author":"A Jaworska","year":"2014","unstructured":"Jaworska A, Malek K (2014) A comparison between adsorption mechanism of tricyclic antidepressants on silver nanoparticles and binding modes on receptors. Surface-enhanced Raman spectroscopy studies. J Colloid Interface Sci 431:117\u2013124. https:\/\/doi.org\/10.1016\/j.jcis.2014.05.060","journal-title":"J Colloid Interface Sci"},{"key":"1943_CR42","first-page":"1187","volume":"62","author":"M Kesim","year":"2012","unstructured":"Kesim M, Yulug E, Kadioglu M, Erkoseoglu I, Aykan DA, Kalyoncu NI, Yaris E (2012) The effect of simvastatin on picrotoxin-induced seizure in mice. J Pak Med Assoc 62:1187\u20131191","journal-title":"J Pak Med Assoc"},{"key":"1943_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/10937404.2013.769418","volume":"16","author":"YW Kim","year":"2013","unstructured":"Kim YW, Kim MJ, Chung BY, Bang DY, Lim SK, Choi SM, Lim DS, Cho MC, Yoon K, Kim HS, Kim KB, Kim YS, Kwack SJ, Lee BM (2013) Safety evaluation and risk assessment of d-limonene. J Toxicol Environ Health 16:17\u201338. https:\/\/doi.org\/10.1080\/10937404.2013.769418","journal-title":"J Toxicol Environ Health"},{"key":"1943_CR44","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.pbb.2015.11.013","volume":"141","author":"M Kubacka","year":"2016","unstructured":"Kubacka M, Mogilski S, Bednarski M, Nowi\u0144ski L, Dudek M, \u017bmudzka E, Siwek A, Waszkielewicz AM, Marona H, Sata\u0142a G, Bojarski A, Filipek B, Pytka K (2016) Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action Pharmacol. Biochem Behav 141:28\u201341. https:\/\/doi.org\/10.1016\/j.pbb.2015.11.013","journal-title":"Biochem Behav"},{"key":"1943_CR45","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1001\/jama.287.17.2215","volume":"287","author":"KE Lasser","year":"2002","unstructured":"Lasser KE, Allen PD, Woolhandler SJ, Himmelstein DU, Wolfe SM, Bor DH (2002) Timing of new black box warnings and withdrawals for prescription medications. JAMA 287:2215\u20132220. https:\/\/doi.org\/10.1001\/jama.287.17.2215","journal-title":"JAMA"},{"key":"1943_CR46","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1872-034X.2008.00419.x","volume":"23","author":"WM Lee","year":"2003","unstructured":"Lee WM (2003) Acetaminophen-related acute liver failure in the United States. Semin Liver Dis 23:217\u2013226. https:\/\/doi.org\/10.1111\/j.1872-034X.2008.00419.x","journal-title":"Semin Liver Dis"},{"key":"1943_CR47","first-page":"65","volume":"246","author":"J Lehmann","year":"1988","unstructured":"Lehmann J, Hutchson AJ, Mcpherson S, Mondadori C, Schmutz MC (1988) GS 19755, a selective and compettitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J Parmacol Exp Ther 246:65\u201372","journal-title":"J Parmacol Exp Ther"},{"key":"1943_CR48","doi-asserted-by":"publisher","unstructured":"Lima SMA, Ara\u00fajo LCC, Sit\u00f4nio MM, Freitas ACC, Moura SL, Correia MTS, Malta DJN, Gon\u00e7alves-Silva T (2012) Anti-inflammatory and analgesic potential of Caesalpinia f\u00e9rrea. Rev Bras 22:169\u2013175. https:\/\/doi.org\/10.1590\/S0102-695X2011005000197","DOI":"10.1590\/S0102-695X2011005000197"},{"key":"1943_CR49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.eplepsyres.2006.03.014","volume":"69","author":"W L\u00f6scher","year":"2006","unstructured":"L\u00f6scher W, Schmidt D (2006) New horizons in the development of antiepileptic drugs: innovative strategies. Epilepsy Res 69:183\u2013272. https:\/\/doi.org\/10.1016\/j.eplepsyres.2006.03.014","journal-title":"Epilepsy Res"},{"key":"1943_CR50","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.fct.2014.03.044","volume":"69","author":"L Lu","year":"2014","unstructured":"Lu L, Fan Y, Yao W, Xie W, Guo J, Yan Y, Yang F, Xu L (2014) Safety assessment of the fermented Phylloporia ribis (Lonicera japonica Thunb.) mycelia by oral acute toxicity study in mice and 90-day feeding study in rats. Food Chem Toxicol 69:18\u201324. https:\/\/doi.org\/10.1016\/j.fct.2014.03.044","journal-title":"Food Chem Toxicol"},{"key":"1943_CR51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1590\/S0102-695X2000000100003","volume":"9","author":"PL Lucio","year":"2000","unstructured":"Lucio PL, Rosalen N, Sharapin ARMS, Souza BARM (2000) Avalia\u00e7\u00e3o toxicol\u00f3gica aguda e screening hipocr\u00e1tico da epiisopilosina, alcal\u00f3ide secund\u00e1rio de Pilocarpus microphyllus Stapf. Rev Bras 9:23\u201325. https:\/\/doi.org\/10.1590\/S0102-695X2000000100003","journal-title":"Rev Bras"},{"key":"1943_CR52","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jep.2013.10.063","volume":"1","author":"MR Martins","year":"2014","unstructured":"Martins MR, Arantes S, Candeias F, Tinoco MT, Cruz-Morais J (2014) Antioxidant, antimicrobial and toxicological properties of Schinus molle L. essential oils. J Ethnopharmacol 1:485\u2013492. https:\/\/doi.org\/10.1016\/j.jep.2013.10.063","journal-title":"J Ethnopharmacol"},{"key":"1943_CR53","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1016\/j.ridd.2010.05.005","volume":"31","author":"JL Matson","year":"2010","unstructured":"Matson JL, Mahan S (2010) Antipsychotic drug side effects for persons with intellectual disability. Res Dev Disabil 31:1570\u20131576. https:\/\/doi.org\/10.1016\/j.ridd.2010.05.005","journal-title":"Res Dev Disabil"},{"key":"1943_CR54","doi-asserted-by":"publisher","unstructured":"McLaughlin JL, Rogers LL (1998) The use of biological assays to evaluate botanicals. Drug Inf J 32:513\u2013524. https:\/\/doi.org\/10.1177\/009286159803200223","DOI":"10.1177\/009286159803200223"},{"key":"1943_CR55","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1055\/s-2007-971236","volume":"45","author":"BN Meyer","year":"1982","unstructured":"Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL (1982) Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med 45:31\u201334. https:\/\/doi.org\/10.1055\/s-2007-971236","journal-title":"Planta Med"},{"key":"1943_CR56","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1055\/s-0032-1328173","volume":"10","author":"GP Morais","year":"2016","unstructured":"Morais GP, Alencar MVOB, Islam T et al (2016) Toxicogenetic profile of rats treated with aqueous extract from Morinda citrifolia fruits. J Med Plant Res 10:18\u201328. https:\/\/doi.org\/10.1055\/s-0032-1328173","journal-title":"J Med Plant Res"},{"key":"1943_CR57","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neulet.2014.11.025","volume":"585","author":"LCGAI Moreno","year":"2015","unstructured":"Moreno LCGAI, Cavalcanti IMF, Satyal P, Santos-Magalhaes NS, Rolim HML, Freitas RM (2015) Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice. Neurosci Lett 585:38\u201342. https:\/\/doi.org\/10.1016\/j.neulet.2014.11.025","journal-title":"Neurosci Lett"},{"key":"1943_CR58","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/S0140-6736(14)60456-6","volume":"385","author":"SL Mosh\u00e9","year":"2015","unstructured":"Mosh\u00e9 SL, Perucca E, Ryvlin P, Tomson T (2015) Epilepsy: new advances. Lancet 385:884\u2013898. https:\/\/doi.org\/10.1016\/S0140-6736(14)60456-6","journal-title":"Lancet"},{"key":"1943_CR59","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbr.2016.03.036","volume":"307","author":"P Mosi\u0144ska","year":"2016","unstructured":"Mosi\u0144ska P, Soca\u0142a K, Nieoczym D, Laudon M, Storr M, Fichna J, Wla\u017a P (2016) Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice. Behav Brain Res 307:199\u2013207. https:\/\/doi.org\/10.1016\/j.bbr.2016.03.036","journal-title":"Behav Brain Res"},{"key":"1943_CR60","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363. https:\/\/doi.org\/10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"1943_CR61","first-page":"42","volume":"8","author":"JD Nogueira Neto","year":"2012","unstructured":"Nogueira Neto JD, Almeida AAC, Silva OA, Carvalho RBF, Sousa DP, Freitas RM (2012) Avalia\u00e7\u00e3o da toxicidade aguda e das propriedades ansiol\u00edticas do nerolidol em camundongos. J Biol Pharm Agr Management 8:42\u201356","journal-title":"J Biol Pharm Agr Management"},{"key":"1943_CR62","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1590\/1415-4714.2014v17n3p528-10","volume":"17","author":"EA Nunes","year":"2014","unstructured":"Nunes EA, Hallak JEC (2014) Modelos animais em psiquiatria: avan\u00e7os e desafios. Rev Latinoam Psicopatol Fundam 17:528\u2013543. https:\/\/doi.org\/10.1590\/1415-4714.2014v17n3p528-10","journal-title":"Rev Latinoam Psicopatol Fundam"},{"key":"1943_CR63","unstructured":"Organization for Economic Co-Operation and Development (OECD) (2018). Test No. 452: chronic toxicity studies. https:\/\/www.oecd.org\/env\/test-no-452-chronic-toxicity-studies-9789264071209-en.htm. (Accessed 19 July 2019)"},{"key":"1943_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1006\/rtph.2000.1399","volume":"32","author":"H Olson","year":"2000","unstructured":"Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sanders J, Sipes G, Bracken W, Dorato M, van Deun K, Smith P, Berger B, Heller A (2000) Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol 32:56\u201367. https:\/\/doi.org\/10.1006\/rtph.2000.1399","journal-title":"Regul Toxicol Pharmacol"},{"key":"1943_CR65","first-page":"327","volume":"229","author":"RD Porsolt","year":"1987","unstructured":"Porsolt RD, Anton NB, Jalfre M (1987) Behavioural despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327\u2013336","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"1943_CR66","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.pharep.2015.08.007","volume":"68","author":"K Pytka","year":"2016","unstructured":"Pytka K, Podkowa K, Rapacz A, Podkowa A, Zmudzka E, Olczyk A, Sapa J, Filipek B (2016) The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect. Pharmacol Rep 68:263\u2013274. https:\/\/doi.org\/10.1016\/j.pharep.2015.08.007","journal-title":"Pharmacol Rep"},{"key":"1943_CR67","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/j.fct.2007.06.007","volume":"45","author":"SK Ramaiah","year":"2007","unstructured":"Ramaiah SK (2007) A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. Food Chem Toxicol 45:1551\u20131557. https:\/\/doi.org\/10.1016\/j.fct.2007.06.007","journal-title":"Food Chem Toxicol"},{"key":"1943_CR68","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.toxrep.2015.01.001","volume":"2","author":"CAF Ramos","year":"2015","unstructured":"Ramos CAF, S\u00e1 RCDS, Alves MF et al (2015) Histopathological and biochemical assessment of d-limonene-induced liver injury in rats. Toxicol Rep 2:482\u2013488. https:\/\/doi.org\/10.1016\/j.toxrep.2015.01.001","journal-title":"Toxicol Rep"},{"key":"1943_CR69","volume-title":"Farmacologia","author":"HP Rang","year":"2007","unstructured":"Rang HP, Dale MM (2007) Farmacologia. Guanabara Koogan, Rio de Janeiro"},{"key":"1943_CR70","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.neuint.2011.05.007","volume":"59","author":"P Rojas","year":"2011","unstructured":"Rojas P, Serrano-Garc\u00eda N, Medina-Campos ON, Pedraza-Chaverri J, Ogren SO, Rojas C (2011) Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress. Neurochem Int 59:628\u2013636. https:\/\/doi.org\/10.1016\/j.neuint.2011.05.007","journal-title":"Neurochem Int"},{"key":"1943_CR71","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.pbb.2010.04.023","volume":"96","author":"L Saxona","year":"2010","unstructured":"Saxona L, Borga S, Hiltunenb AJ (2010) Reduction of aggression during benzodiazepine withdrawal: effects of flumazenil. Pharmacol Biochem Behav 96:148\u2013151. https:\/\/doi.org\/10.1016\/j.pbb.2010.04.023","journal-title":"Pharmacol Biochem Behav"},{"key":"1943_CR72","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.yrtph.2016.11.022","volume":"83","author":"NAAM Shalan","year":"2017","unstructured":"Shalan NAAM, Mustapha NM, Mohamed S (2017) Chronic toxicity evaluation of Morinda citrifolia fruit and leaf in mice. Regul Toxicol Pharmacol 83:46\u201353. https:\/\/doi.org\/10.1016\/j.yrtph.2016.11.022","journal-title":"Regul Toxicol Pharmacol"},{"key":"1943_CR73","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.yrtph","volume":"17","author":"T Shimada","year":"2002","unstructured":"Shimada T, Shindo M, Miyazawa M (2002) Diferen\u00e7as de esp\u00e9cies no matabolismo de (+) - e (-) - limonenos e seus metabolitos, carve\u00f3is e carv\u00f5es, pelas enzimas do citocromo P450 em microssomas hep\u00e1ticos de ratos, cobaias, coelhos, c\u00e3es e macacos. Drug Metab Pharmacokinet 17:507\u2013515. https:\/\/doi.org\/10.1016\/j.yrtph","journal-title":"Drug Metab Pharmacokinet"},{"key":"1943_CR74","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1590\/S1984-82502012000200011","volume":"48","author":"ER Silva","year":"2012","unstructured":"Silva ER, Diedrich D, Bolzan RC, Giacomelli SR (2012) Toxicological and pharmacological evaluation of Discaria americana Gillies & Hook (Rhamnaceae) in mice. Braz J Pharm Sci 48:273\u2013280. https:\/\/doi.org\/10.1590\/S1984-82502012000200011","journal-title":"Braz J Pharm Sci"},{"key":"1943_CR75","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1590\/1809-4392201501746","volume":"46","author":"SL Silva","year":"2016","unstructured":"Silva SL, Nascimento AA, Ribeiro EFB et al (2016) Preclinical acute toxicological evaluation of the methanolic stem bark extract of Parahancornia amapa (Apocynaceae). Acta Amaz 46:73\u201380. https:\/\/doi.org\/10.1590\/1809-4392201501746","journal-title":"Acta Amaz"},{"key":"1943_CR76","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.nurt.2006.11.009","volume":"4","author":"M Smith","year":"2007","unstructured":"Smith M, Wilcox KS, White HS (2007) Discovery of antiepileptic drugs. J Am Soc Exp Neuro Ther 4:12\u201317. https:\/\/doi.org\/10.1016\/j.nurt.2006.11.009","journal-title":"J Am Soc Exp Neuro Ther"},{"key":"1943_CR77","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00428203","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367\u2013370. https:\/\/doi.org\/10.1007\/BF00428203","journal-title":"Psychopharmacology"},{"key":"1943_CR78","doi-asserted-by":"publisher","first-page":"172743","DOI":"10.1016\/j.pbb.2019.172743","volume":"184","author":"K Szczechowiak","year":"2019","unstructured":"Szczechowiak K, Diniz BS, Leszek J (2019) Diet and Alzheimer\u2019s dementia \u2013 nutritional approach to modulate inflammation. Pharmacol Biochem Behav 184:172743. https:\/\/doi.org\/10.1016\/j.pbb.2019.172743","journal-title":"Pharmacol Biochem Behav"},{"key":"1943_CR79","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.pbb.2019.02.011","volume":"179","author":"B Tsang","year":"2019","unstructured":"Tsang B, Ansari R, Gerlai R (2019) Dose dependent behavioral effects of acute alcohol administration in zebrafish fry. Pharmacol Biochem Behav 179:124\u2013133. https:\/\/doi.org\/10.1016\/j.pbb.2019.02.011","journal-title":"Pharmacol Biochem Behav"},{"key":"1943_CR80","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1176\/appi.ajp.2013.13050709","volume":"4","author":"CS Voican","year":"2014","unstructured":"Voican CS, Corruble E, Naveau S, Perlemuter G (2014) Antidepressant-induced liver injury: a review for clinicians. Am J Psychiatry 4:404\u2013415. https:\/\/doi.org\/10.1176\/appi.ajp.2013.13050709","journal-title":"Am J Psychiatry"},{"key":"1943_CR81","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jep.2015.12.029","volume":"179","author":"YL Wang","year":"2016","unstructured":"Wang YL, Wang JX, Hu XX, Chen L, Qiu ZK, Zhao N, Yu ZD, Sun SZ, Xu YY, Guo Y, Liu C, Zhang YZ, Li YF, Yu CX (2016) Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba. J Ethnopharmacol 179:9\u201315. https:\/\/doi.org\/10.1016\/j.jep.2015.12.029","journal-title":"J Ethnopharmacol"},{"key":"1943_CR82","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ejphar.2012.11.063","volume":"700","author":"A Wasik","year":"2013","unstructured":"Wasik A, Mozdzen E, Romanska I, Michaluk J, Antkiewicz-Michaluk L (2013) Antidepressant-like activity of the endogenous amine, 1-methyl-1,2,3,4 tetrahydroisoquinoline in the behavioral despair test in the rat, and its neurochemical correlates: a comparison with the classical antidepressant, imipramine. Eur J Pharmacol 700:110\u2013117. https:\/\/doi.org\/10.1016\/j.ejphar.2012.11.063","journal-title":"Eur J Pharmacol"},{"key":"1943_CR83","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.kjms.2015.10.009","volume":"31","author":"S Yan","year":"2015","unstructured":"Yan S, You ZL, Zhao QY, Peng C, He G, Gou XJ, Lin B (2015) Antidepressant-like effects of sanyuansan in the mouse forced swim test, tail suspension test, and chronic mild stress model. Kaohsiung J Med Sci 31:605\u2013612. https:\/\/doi.org\/10.1016\/j.kjms.2015.10.009","journal-title":"Kaohsiung J Med Sci"},{"key":"1943_CR84","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.bbr.2011.12.017","volume":"228","author":"L Zhen","year":"2012","unstructured":"Zhen L, Zhu J, Zhao X, Huang W, Ane Y, Li S, Du X, Lin M, Wang Q, Xu Y, Pa J (2012) The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system. Behav Brain Res 228:359\u2013366. https:\/\/doi.org\/10.1016\/j.bbr.2011.12.017","journal-title":"Behav Brain Res"},{"key":"1943_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2011.12.035","volume":"1439","author":"H Zhu","year":"2012","unstructured":"Zhu H, Chen M, Yu W et al (2012) Time-dependent changes in BDNF expression of pentylenetetrazole-induced hippocampal astrocytes in vitro. Brain Res 1439:1\u20136. https:\/\/doi.org\/10.1016\/j.brainres.2011.12.035","journal-title":"Brain Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01943-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01943-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01943-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T23:09:54Z","timestamp":1625958594000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-020-01943-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,11]]},"references-count":85,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1943"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-01943-w","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,11]]},"assertion":[{"value":"28 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures were approved by the Committee on Animal Research at UFPI (#091\/2014) and followed Brazilian (<i>Col\u00e9gio Brasileiro de Experimenta\u00e7\u00e3o Animal<\/i> - COBEA) and International rules on the care and use of experimental animals (Directive 2010\/63\/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}