{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:52:36Z","timestamp":1768618356190,"version":"3.49.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00210-020-01956-5","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T23:02:16Z","timestamp":1596409336000},"page":"2463-2472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Can aprepitant used for nausea and vomiting be good gastrointestinal complaints?"],"prefix":"10.1007","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-2343","authenticated-orcid":false,"given":"Rustem Anil","family":"Ugan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harun","family":"Un","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Kose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Cadirci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba","family":"Bal Tastan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Yayla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"1956_CR1","first-page":"120","volume":"5","author":"A Agro","year":"1993","unstructured":"Agro A, Stanisz AM (1993) Inhibition of murine intestinal inflammation by anti-substance P antibody. Reg Immunol 5:120\u2013126","journal-title":"Reg Immunol"},{"key":"1956_CR2","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.acthis.2015.07.006","volume":"117","author":"S Aksak Karamese","year":"2015","unstructured":"Aksak Karamese S, Toktay E, Unal D, Selli J, Karamese M, Malkoc I (2015) The protective effects of beta-carotene against ischemia\/reperfusion injury in rat ovarian tissue. Acta Histochem 117:790\u2013797. https:\/\/doi.org\/10.1016\/j.acthis.2015.07.006","journal-title":"Acta Histochem"},{"key":"1956_CR3","doi-asserted-by":"publisher","unstructured":"Alkan E, Ugan RA, Basar MM, Halici Z, Karakus E, Balbay MD, Un H (2017) Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats. Andrologia:49. https:\/\/doi.org\/10.1111\/and.12607","DOI":"10.1111\/and.12607"},{"key":"1956_CR4","doi-asserted-by":"publisher","first-page":"4189","DOI":"10.1200\/JCO.2010.34.4614","volume":"29","author":"E Basch","year":"2011","unstructured":"Basch E et al (2011) Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 29:4189\u20134198. https:\/\/doi.org\/10.1200\/JCO.2010.34.4614","journal-title":"J Clin Oncol"},{"key":"1956_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.brainresbull.2013.01.004","volume":"91","author":"SB Brancati","year":"2013","unstructured":"Brancati SB, Zadori ZS, Nemeth J, Gyires K (2013) Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats. Brain Res Bull 91:38\u201345. https:\/\/doi.org\/10.1016\/j.brainresbull.2013.01.004","journal-title":"Brain Res Bull"},{"key":"1956_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00210-018-1571-8","volume":"392","author":"E Cadirci","year":"2019","unstructured":"Cadirci E, Ugan RA, Dincer B, Gundogdu B, Cinar I, Akpinar E, Halici Z (2019) Urotensin receptors as a new target for CLP induced septic lung injury in mice. Naunyn Schmiedeberg's Arch Pharmacol 392:135\u2013145. https:\/\/doi.org\/10.1007\/s00210-018-1571-8","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"1956_CR7","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s40618-015-0282-y","volume":"38","author":"A Cayir","year":"2015","unstructured":"Cayir A et al (2015) The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus. J Endocrinol Investig 38:987\u2013998. https:\/\/doi.org\/10.1007\/s40618-015-0282-y","journal-title":"J Endocrinol Investig"},{"key":"1956_CR8","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1177\/0960327120916821","volume":"39","author":"I Cinar","year":"2020","unstructured":"Cinar I, Halici Z, Dincer B, Sirin B, Cadirci E (2020) The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction. Hum Exp Toxicol 39:1005\u20131018. https:\/\/doi.org\/10.1177\/0960327120916821","journal-title":"Hum Exp Toxicol"},{"key":"1956_CR9","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.nut.2016.01.010","volume":"32","author":"NE El-Ashmawy","year":"2016","unstructured":"El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM (2016) Gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats. Nutrition 32:849\u2013854. https:\/\/doi.org\/10.1016\/j.nut.2016.01.010","journal-title":"Nutrition"},{"key":"1956_CR10","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.peptides.2012.03.018","volume":"35","author":"N Erin","year":"2012","unstructured":"Erin N, Turker S, Elpek O, Yildirim B (2012) Differential changes in substance P, VIP as well as neprilysin levels in patients with gastritis or ulcer. Peptides 35:218\u2013224. https:\/\/doi.org\/10.1016\/j.peptides.2012.03.018","journal-title":"Peptides"},{"key":"1956_CR11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/Bf00506259","volume":"317","author":"F Erjavec","year":"1981","unstructured":"Erjavec F, Lembeck F, Florjancirman T, Skofitsch G, Donnerer J, Saria A, Holzer P (1981) Release of histamine by substance-P N-S. Arch Pharmacol 317:67\u201370. https:\/\/doi.org\/10.1007\/Bf00506259","journal-title":"Arch Pharmacol"},{"key":"1956_CR12","first-page":"457","volume":"38","author":"K Fukuhara","year":"2011","unstructured":"Fukuhara K, Terakura M, Katsuragi K (2011) Severe gastric and duodenal ulcer after chemotherapy of mFOLFOX6 and bevacizumab. Gan To Kagaku Ryoho 38:457\u2013459","journal-title":"Gan To Kagaku Ryoho"},{"key":"1956_CR13","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1111\/j.1476-5381.2008.00033.x","volume":"156","author":"M Gallicchio","year":"2009","unstructured":"Gallicchio M, Benetti E, Rosa AC, Fantozzi R (2009) Tachykinin receptor modulation of cyclooxygenase-2 expression in human polymorphonuclear leucocytes. Brit J Pharmacol 156:486\u2013496. https:\/\/doi.org\/10.1111\/j.1476-5381.2008.00033.x","journal-title":"Brit J Pharmacol"},{"key":"1956_CR14","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/sj.bjp.0706660","volume":"147","author":"M Gallicchio","year":"2006","unstructured":"Gallicchio M, Rosa AC, Benetti E, Collino M, Dianzani C, Fantozzi R (2006) Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells. Brit J Pharmacol 147:681\u2013689. https:\/\/doi.org\/10.1038\/sj.bjp.0706660","journal-title":"Brit J Pharmacol"},{"key":"1956_CR15","doi-asserted-by":"publisher","first-page":"10640","DOI":"10.1021\/bi00108a006","volume":"30","author":"NP Gerard","year":"1991","unstructured":"Gerard NP, Garraway LA, Eddy RL, Shows TB, Iijima H, Paquet JL, Gerard C (1991) Human substance-P receptor (Nk-1) - organization of the gene, chromosome localization, and functional expression of Cdna clones. Biochemistry-Us 30:10640\u201310646. https:\/\/doi.org\/10.1021\/bi00108a006","journal-title":"Biochemistry-Us"},{"key":"1956_CR16","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.cbi.2016.09.011","volume":"258","author":"Z Halici","year":"2016","unstructured":"Halici Z et al (2016) Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. Chem Biol Interact 258:266\u2013275. https:\/\/doi.org\/10.1016\/j.cbi.2016.09.011","journal-title":"Chem Biol Interact"},{"key":"1956_CR17","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.4049\/jimmunol.136.10.3856","volume":"136","author":"HP Hartung","year":"1986","unstructured":"Hartung HP, Wolters K, Toyka KV (1986) Substance-P - binding-properties and studies on cellular-responses in guinea-pig macrophages. J Immunol 136:3856\u20133863","journal-title":"J Immunol"},{"key":"1956_CR18","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1111\/j.1476-5381.1996.tb16068.x","volume":"119","author":"A Heinemann","year":"1996","unstructured":"Heinemann A, Jocic M, Herzeg G, Holzer P (1996) Tachykinin inhibition of acid-induced gastric hyperaemia in the rat. Brit J Pharmacol 119:1525\u20131532. https:\/\/doi.org\/10.1111\/j.1476-5381.1996.tb16068.x","journal-title":"Brit J Pharmacol"},{"key":"1956_CR19","doi-asserted-by":"publisher","first-page":"G309","DOI":"10.1152\/ajpgi.1986.250.3.G309","volume":"250","author":"B Holstein","year":"1986","unstructured":"Holstein B, Cederberg C (1986) Effects of tachykinins on gastric acid and pepsin secretion and on gastric outflow in the Atlantic cod, Gadus morhua. Am J Phys 250:G309\u2013G315. https:\/\/doi.org\/10.1152\/ajpgi.1986.250.3.G309","journal-title":"Am J Phys"},{"key":"1956_CR20","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/0016-5085(91)70006-J","volume":"100","author":"F Karmeli","year":"1991","unstructured":"Karmeli F, Eliakim R, Okon E, Rachmilewitz D (1991) Gastric-mucosal damage by ethanol is mediated by substance-P and prevented by ketotifen, a mast-cell stabilizer. Gastroenterology 100:1206\u20131216","journal-title":"Gastroenterology"},{"key":"1956_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0167-4889(96)00026-2","volume":"1312","author":"Y Kitsukawa","year":"1996","unstructured":"Kitsukawa Y, Turner RJ, Pradhan TK, Jensen RT (1996) Gastric chief cells possess NK1 receptors which mediate pepsinogen secretion and are regulated by agents that increase cAMP and phospholipase C. Bba-Mol Cell Res 1312:105\u2013116. https:\/\/doi.org\/10.1016\/0167-4889(96)00026-2","journal-title":"Bba-Mol Cell Res"},{"key":"1956_CR22","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2165\/00002018-199920060-00006","volume":"20","author":"R La Corte","year":"1999","unstructured":"La Corte R, Caselli M, Castellino G, Bajocchi G, Trotta F (1999) Prophylaxis and treatment of NSAID-induced gastroduodenal disorders. Drug Saf 20:527\u2013543. https:\/\/doi.org\/10.2165\/00002018-199920060-00006","journal-title":"Drug Saf"},{"key":"1956_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.autneu.2003.11.003","volume":"110","author":"M Larauche","year":"2004","unstructured":"Larauche M, Anton PM, Peiro G, Eutamene H, Bueno L, Fioramonti J (2004) Role of capsaicin-sensitive afferent nerves in different models of gastric inflammation in rats. Auton Neurosci 110:89\u201397. https:\/\/doi.org\/10.1016\/j.autneu.2003.11.003","journal-title":"Auton Neurosci"},{"key":"1956_CR24","doi-asserted-by":"publisher","first-page":"9475","DOI":"10.1073\/pnas.94.17.9475","volume":"94","author":"HZ Li","year":"1997","unstructured":"Li HZ et al (1997) A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization. P Natl Acad Sci USA 94:9475\u20139480. https:\/\/doi.org\/10.1073\/pnas.94.17.9475","journal-title":"P Natl Acad Sci USA"},{"key":"1956_CR25","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s10753-018-0888-2","volume":"42","author":"BK Liu","year":"2019","unstructured":"Liu BK, Jin XW, Lu HZ, Zhang X, Zhao ZH, Shao Y (2019a) The effects of neurokinin-1 receptor antagonist in an experimental autoimmune cystitis model resembling bladder pain syndrome\/interstitial cystitis. Inflammation 42:246\u2013254. https:\/\/doi.org\/10.1007\/s10753-018-0888-2","journal-title":"Inflammation"},{"key":"1956_CR26","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1080\/21691401.2019.1573177","volume":"47","author":"XP Liu","year":"2019","unstructured":"Liu XP, Zhu YL, Zheng W, Qian TL, Wang HY, Hou XJ (2019b) Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes. Artif Cell Nanomed B 47:1628\u20131634. https:\/\/doi.org\/10.1080\/21691401.2019.1573177","journal-title":"Artif Cell Nanomed B"},{"key":"1956_CR27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212delta delta C(T)) method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"1956_CR28","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00280-017-3426-2","volume":"80","author":"ZN Lu","year":"2017","unstructured":"Lu ZN, Tian B, Guo XL (2017) Repositioning of proton pump inhibitors in cancer therapy. Cancer Chemother Pharmacol 80:925\u2013937. https:\/\/doi.org\/10.1007\/s00280-017-3426-2","journal-title":"Cancer Chemother Pharmacol"},{"key":"1956_CR29","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/0006-291x(81)90727-0","volume":"99","author":"WA Marasco","year":"1981","unstructured":"Marasco WA, Showell HJ, Becker EL (1981) Substance-P binds to the formylpeptide chemotaxis receptor on the rabbit neutrophil. Biochem Bioph Res Co 99:1065\u20131072. https:\/\/doi.org\/10.1016\/0006-291x(81)90727-0","journal-title":"Biochem Bioph Res Co"},{"key":"1956_CR30","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1124\/dmd.108.021758","volume":"36","author":"E Minthorn","year":"2008","unstructured":"Minthorn E et al (2008) Pharmacokinetics and brain penetration of casopitant, a potent and selective neurokinin-1 receptor antagonist, in the ferret. Drug Metab Dispos 36:1846\u20131852. https:\/\/doi.org\/10.1124\/dmd.108.021758","journal-title":"Drug Metab Dispos"},{"key":"1956_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"1956_CR32","doi-asserted-by":"publisher","first-page":"441","DOI":"10.4103\/0970-9185.222511","volume":"33","author":"D Okafor","year":"2017","unstructured":"Okafor D, Kaye AD, Kaye RJ, Urman RD (2017) The role of neurokinin-1 (substance P) antagonists in the prevention of postoperative nausea and vomiting. J Anaesthesiol Clin Pharmacol 33:441\u2013445. https:\/\/doi.org\/10.4103\/0970-9185.222511","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"1956_CR33","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.4049\/jimmunol.131.4.1613","volume":"131","author":"DG Payan","year":"1983","unstructured":"Payan DG, Brewster DR, Goetzl EJ (1983) Specific stimulation of human lymphocytes-t by substance-P. J Immunol 131:1613\u20131615","journal-title":"J Immunol"},{"key":"1956_CR34","first-page":"1005","volume":"76","author":"K Ramakrishnan","year":"2007","unstructured":"Ramakrishnan K, Salinas RC (2007) Peptic ulcer disease. Am Fam Physician 76:1005\u20131012","journal-title":"Am Fam Physician"},{"key":"1956_CR35","doi-asserted-by":"publisher","first-page":"381434","DOI":"10.1100\/2012\/381434","volume":"2012","author":"M Rosso","year":"2012","unstructured":"Rosso M, Munoz M, Berger M (2012) The role of neurokinin-1 receptor in the microenvironment of inflammation and cancer. Sci World J 2012:381434. https:\/\/doi.org\/10.1100\/2012\/381434","journal-title":"Sci World J"},{"key":"1956_CR36","first-page":"G1064","volume":"277","author":"A Rydning","year":"1999","unstructured":"Rydning A, Lyng O, Aase S, Gronbech JE (1999) Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa. Am J Physiol-Gastr L 277:G1064\u2013G1073","journal-title":"Am J Physiol-Gastr L"},{"key":"1956_CR37","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/Pl00000720","volume":"57","author":"PT Schmidt","year":"2000","unstructured":"Schmidt PT, Holst JJ (2000) Tachykinins in regulation of gastric motility and secretion. Cell Mol Life Sci 57:579\u2013588. https:\/\/doi.org\/10.1007\/Pl00000720","journal-title":"Cell Mol Life Sci"},{"key":"1956_CR38","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25:192\u2013205. https:\/\/doi.org\/10.1016\/0003-2697(68)90092-4","journal-title":"Anal Biochem"},{"key":"1956_CR39","doi-asserted-by":"publisher","unstructured":"Shukla K, Raj P, Kumar A, Kumar M, Kaithwas G (2014) Effect of monotherapy and combination therapy of pantoprazole and aprepitant in gastric esophageal reflux disease in albino rats. Sci World J doi:Artn:183147. https:\/\/doi.org\/10.1155\/2014\/183147","DOI":"10.1155\/2014\/183147"},{"key":"1956_CR40","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/ar.20737","volume":"291","author":"G Sipos","year":"2008","unstructured":"Sipos G, Sipos P, Altdorfer K, Pongor E, Feher E (2008) Correlation and immunolocalization of substance P nerve fibers and activated immune cells in human chronic gastritis. Anat Rec (Hoboken) 291:1140\u20131148. https:\/\/doi.org\/10.1002\/ar.20737","journal-title":"Anat Rec (Hoboken)"},{"key":"1956_CR41","doi-asserted-by":"publisher","first-page":"112979","DOI":"10.1016\/j.jep.2020.112979","volume":"259","author":"H Song","year":"2020","unstructured":"Song H et al (2020) Traditional Chinese medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2\/MyD88 signaling pathway. J Ethnopharmacol 259:112979. https:\/\/doi.org\/10.1016\/j.jep.2020.112979","journal-title":"J Ethnopharmacol"},{"key":"1956_CR42","first-page":"255","volume":"54","author":"H Suleyman","year":"2002","unstructured":"Suleyman H, Altinkaynak K, Gocer F, Maras A, Akcay F, Onuk MD, Gepdiremen A (2002) Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue. Pol J Pharmacol 54:255\u2013259","journal-title":"Pol J Pharmacol"},{"key":"1956_CR43","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","volume":"34","author":"Y Sun","year":"1988","unstructured":"Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497\u2013500","journal-title":"Clin Chem"},{"key":"1956_CR44","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.ejphar.2017.11.011","volume":"818","author":"RA Ugan","year":"2018","unstructured":"Ugan RA, Cadirci E, Halici Z, Toktay E, Cinar I (2018) The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions. Eur J Pharmacol 818:457\u2013469. https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.011","journal-title":"Eur J Pharmacol"},{"key":"1956_CR45","doi-asserted-by":"publisher","first-page":"173168","DOI":"10.1016\/j.ejphar.2020.173168","volume":"880","author":"H Un","year":"2020","unstructured":"Un H, Ugan RA, Kose D, Bayir Y, Cadirci E, Selli J, Halici Z (2020) A novel effect of aprepitant: protection for cisplatin-induced nephrotoxicity and hepatotoxicity. Eur J Pharmacol 880:173168. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173168","journal-title":"Eur J Pharmacol"},{"key":"1956_CR46","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/j.1749-6632.1999.tb07907.x","volume":"897","author":"J Vanden Broeck","year":"1999","unstructured":"Vanden Broeck J, Torfs H, Poels J, Van Poyer W, Swinnen E, Ferket K, De Loof A (1999) Tachykinin-like peptides and their receptors - a review. Ann N Y Acad Sci 897:374\u2013387. https:\/\/doi.org\/10.1111\/j.1749-6632.1999.tb07907.x","journal-title":"Ann N Y Acad Sci"},{"key":"1956_CR47","doi-asserted-by":"publisher","first-page":"505","DOI":"10.3949\/ccjm.59.5.505","volume":"59","author":"D Walsh","year":"1992","unstructured":"Walsh D, Avashia J (1992) Glucocorticoids in clinical oncology. Cleve Clin J Med 59:505\u2013515. https:\/\/doi.org\/10.3949\/ccjm.59.5.505","journal-title":"Cleve Clin J Med"},{"key":"1956_CR48","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.jep.2011.07.042","volume":"137","author":"R Xue","year":"2011","unstructured":"Xue R, Cao Y, Han N, Lin X, Liu Z, Yin J (2011) Activity of DBXX granules on anti-gastric ulcer and decreasing the side effect of chemotherapy in S180 tumor-bearing mice. J Ethnopharmacol 137:1156\u20131160. https:\/\/doi.org\/10.1016\/j.jep.2011.07.042","journal-title":"J Ethnopharmacol"},{"key":"1956_CR49","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S1566-0702(02)00293-X","volume":"104","author":"L Yip","year":"2003","unstructured":"Yip L, Kwok YN, Buchan AM (2003) Cellular localization and distribution of neurokinin-1 receptors in the rat stomach. Auton Neurosci 104:95\u2013108. https:\/\/doi.org\/10.1016\/S1566-0702(02)00293-X","journal-title":"Auton Neurosci"},{"key":"1956_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00418-018-1715-4","volume":"151","author":"M Zalecki","year":"2019","unstructured":"Zalecki M (2019) Gastric ulcer induced changes in substance P and Nk1, Nk2, Nk3 receptors expression in different stomach localizations with regard to intrinsic neuronal system. Histochem Cell Biol 151:29\u201342. https:\/\/doi.org\/10.1007\/s00418-018-1715-4","journal-title":"Histochem Cell Biol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01956-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01956-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01956-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:39:36Z","timestamp":1696484376000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-020-01956-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,3]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1956"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-01956-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,3]]},"assertion":[{"value":"5 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}