{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:44:26Z","timestamp":1792043066786,"version":"4.4.0"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00210-020-01957-4","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T23:21:07Z","timestamp":1597015267000},"page":"11-31","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["RETRACTED ARTICLE: Cardioprotective role of GTS-21 by attenuating the TLR4\/NF-\u03baB pathway in streptozotocin-induced diabetic cardiomyopathy in rats"],"prefix":"10.1007","volume":"394","author":[{"given":"Mahmoud E.","family":"Youssef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba M.","family":"Abdelrazek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser M.","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"1957_CR1","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1007\/s10753-019-01068-0","volume":"42","author":"SA Abdo","year":"2019","unstructured":"Abdo SA, Wadie W, Abdelsalam RM, Khattab MM (2019) Potential anti-inflammatory effect of escitalopram in iodoacetamide-induced colitis in depressed ovariectomized rats: role of alpha7-nAChR. Inflammation 42:2056\u20132064. https:\/\/doi.org\/10.1007\/s10753-019-01068-0","journal-title":"Inflammation"},{"key":"1957_CR2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s12031-009-9236-1","volume":"40","author":"A Akaike","year":"2010","unstructured":"Akaike A, Takada-Takatori Y, Kume T, Izumi Y (2010) Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci 40:211\u2013216. https:\/\/doi.org\/10.1007\/s12031-009-9236-1","journal-title":"J Mol Neurosci"},{"key":"1957_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.5681\/jcvtr.2014.019","volume":"6","author":"T Akgun","year":"2014","unstructured":"Akgun T, Kalkan S, Tigen MK (2014) Variations of QRS morphology in patients with dilated cardiomyopathy; clinical and prognostic implications. J Cardiovasc Thorac Res 6:85\u201389. https:\/\/doi.org\/10.5681\/jcvtr.2014.019","journal-title":"J Cardiovasc Thorac Res"},{"key":"1957_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ihj.2015.09.026","volume":"68","author":"Ali","year":"2016","unstructured":"Ali, Naqvi SA, Bismillah M, Wajid N (2016) Comparative analysis of biochemical parameters in diabetic and non-diabetic acute myocardial infarction patients. Indian heart journal 68:325\u2013331. https:\/\/doi.org\/10.1016\/j.ihj.2015.09.026","journal-title":"Indian heart journal"},{"key":"1957_CR5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.amjms.2019.10.005","volume":"359","author":"TM Ali","year":"2020","unstructured":"Ali TM, Abo-Salem OM, El Esawy BH, El Askary A (2020) The potential protective effects of diosmin on streptozotocin-induced diabetic cardiomyopathy in rats. Am J Med Sci 359:32\u201341. https:\/\/doi.org\/10.1016\/j.amjms.2019.10.005","journal-title":"Am J Med Sci"},{"key":"1957_CR6","doi-asserted-by":"publisher","first-page":"1092015","DOI":"10.1155\/2017\/1092015","volume":"2017","author":"NM Al-Rasheed","year":"2017","unstructured":"Al-Rasheed NM, Al-Rasheed NM, Hasan IH, Al-Amin MA, Al-Ajmi HN, Mohamad RA, Mahmoud AM (2017) Simvastatin ameliorates diabetic cardiomyopathy by attenuating oxidative stress and inflammation in rats. Oxid Med Cell Longev 2017:1092015\u20131092013. https:\/\/doi.org\/10.1155\/2017\/1092015","journal-title":"Oxid Med Cell Longev"},{"key":"1957_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2459\/JCM.0000000000000432","volume":"18","author":"M Araco","year":"2017","unstructured":"Araco M, Merlo M, Carr-White G, Sinagra G (2017) Genetic bases of dilated cardiomyopathy. J Cardiovasc Med 18:123\u2013130. https:\/\/doi.org\/10.2459\/JCM.0000000000000432","journal-title":"J Cardiovasc Med"},{"key":"1957_CR8","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/0006-8993(94)01449-r","volume":"674","author":"GW Arendash","year":"1995","unstructured":"Arendash GW, Sengstock GJ, Sanberg PR, Kem WR (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res 674:252\u2013259. https:\/\/doi.org\/10.1016\/0006-8993(94)01449-r","journal-title":"Brain Res"},{"key":"1957_CR9","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.hrthm.2019.01.019","volume":"16","author":"FR Assis","year":"2019","unstructured":"Assis FR et al (2019) Cardiac sympathectomy for refractory ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm 16:1003\u20131010. https:\/\/doi.org\/10.1016\/j.hrthm.2019.01.019","journal-title":"Heart Rhythm"},{"key":"1957_CR10","doi-asserted-by":"publisher","first-page":"173004","DOI":"10.1016\/j.ejphar.2020.173004","volume":"873","author":"S Babu","year":"2020","unstructured":"Babu S, Krishnan M, Rajagopal P, Periyasamy V, Veeraraghavan V, Govindan R, Jayaraman S (2020) Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1\/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats. Eur J Pharmacol 873:173004. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173004","journal-title":"Eur J Pharmacol"},{"key":"1957_CR11","first-page":"299","volume":"22","author":"M Beylot","year":"1996","unstructured":"Beylot M (1996) Regulation of in vivo ketogenesis: role of free fatty acids and control by epinephrine, thyroid hormones, insulin and glucagon. Diabetes Metab 22:299\u2013304","journal-title":"Diabetes Metab"},{"key":"1957_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.imlet.2017.09.011","volume":"195","author":"S Bhattacharyya","year":"2018","unstructured":"Bhattacharyya S, Varga J (2018) Endogenous ligands of TLR4 promote unresolving tissue fibrosis: implications for systemic sclerosis and its targeted therapy. Immunol Lett 195:9\u201317. https:\/\/doi.org\/10.1016\/j.imlet.2017.09.011","journal-title":"Immunol Lett"},{"key":"1957_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-immunol-032414-112240","volume":"33","author":"SW Brubaker","year":"2015","unstructured":"Brubaker SW, Bonham KS, Zanoni I, Kagan JC (2015) Innate immune pattern recognition: a cell biological perspective. Ann Rev Immunol 33:257\u2013290. https:\/\/doi.org\/10.1146\/annurev-immunol-032414-112240","journal-title":"Ann Rev Immunol"},{"key":"1957_CR14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11010-018-3394-9","volume":"451","author":"Y Bulani","year":"2019","unstructured":"Bulani Y, Srinivasan K, Sharma SS (2019) Attenuation of type-1 diabetes-induced cardiovascular dysfunctions by direct thrombin inhibitor in rats: a mechanistic study. Mol Cell Biochem 451:69\u201378. https:\/\/doi.org\/10.1007\/s11010-018-3394-9","journal-title":"Mol Cell Biochem"},{"key":"1957_CR15","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1007\/s00213-014-3509-2","volume":"231","author":"PM Callahan","year":"2014","unstructured":"Callahan PM, Terry AV Jr, Tehim A (2014) Effects of the nicotinic alpha7 receptor partial agonist GTS-21 on NMDA-glutamatergic receptor related deficits in sensorimotor gating and recognition memory in rats. Psychopharmacology 231:3695\u20133706. https:\/\/doi.org\/10.1007\/s00213-014-3509-2","journal-title":"Psychopharmacology"},{"key":"1957_CR16","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1038\/ijo.2011.275","volume":"36","author":"R Cancello","year":"2012","unstructured":"Cancello R et al (2012) The nicotinic acetylcholine receptor alpha7 in subcutaneous mature adipocytes: downregulation in human obesity and modulation by diet-induced weight loss. Int J Obes 36:1552\u20131557. https:\/\/doi.org\/10.1038\/ijo.2011.275","journal-title":"Int J Obes"},{"key":"1957_CR17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.lungcan.2018.12.029","volume":"128","author":"JL Cedillo","year":"2019","unstructured":"Cedillo JL et al (2019) Anti-tumoral activity of the human-specific duplicated form of alpha7-nicotinic receptor subunit in tobacco-induced lung cancer progression. Lung Cancer 128:134\u2013144. https:\/\/doi.org\/10.1016\/j.lungcan.2018.12.029","journal-title":"Lung Cancer"},{"key":"1957_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.11613\/bm.2013.033","volume":"23","author":"S Cernea","year":"2013","unstructured":"Cernea S, Dobreanu M (2013) Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochem Med 23:266\u2013280. https:\/\/doi.org\/10.11613\/bm.2013.033","journal-title":"Biochem Med"},{"key":"1957_CR19","doi-asserted-by":"publisher","first-page":"e0188797","DOI":"10.1371\/journal.pone.0188797","volume":"12","author":"PK Chatterjee","year":"2017","unstructured":"Chatterjee PK et al (2017) Activation of the cholinergic anti-inflammatory pathway by GTS-21 attenuates cisplatin-induced acute kidney injury in mice. PloS one 12:e0188797. https:\/\/doi.org\/10.1371\/journal.pone.0188797","journal-title":"PloS one"},{"key":"1957_CR20","first-page":"2534","volume":"8","author":"Chen","year":"2016","unstructured":"Chen et al (2016) JNK\/PI3K\/Akt signaling pathway is involved in myocardial ischemia\/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention. Am J Transl Res 8:2534\u20132548","journal-title":"Am J Transl Res"},{"key":"1957_CR21","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.3892\/mmr.2017.7166","volume":"16","author":"K Chen","year":"2017","unstructured":"Chen K, Sun Y, Diao Y, Ji L, Song D, Zhang T (2017) alpha7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4\/Myd88\/NFkappaB signaling pathway during cardiopulmonary bypass. Mol Med Rep 16:4770\u20134776. https:\/\/doi.org\/10.3892\/mmr.2017.7166","journal-title":"Mol Med Rep"},{"key":"1957_CR22","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1476-5381.2010.01034.x","volume":"162","author":"L del Barrio","year":"2011","unstructured":"del Barrio L et al (2011) Calcium signalling mediated through alpha7 and non-alpha7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release. Br J Pharmacol 162:94\u2013110. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.01034.x","journal-title":"Br J Pharmacol"},{"key":"1957_CR23","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ejphar.2018.06.034","volume":"833","author":"S Dewanjee","year":"2018","unstructured":"Dewanjee S et al (2018) Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets. Eur J Pharmacol 833:472\u2013523. https:\/\/doi.org\/10.1016\/j.ejphar.2018.06.034","journal-title":"Eur J Pharmacol"},{"key":"1957_CR24","doi-asserted-by":"publisher","first-page":"H732","DOI":"10.1152\/ajpheart.00948.2011","volume":"303","author":"B Dong","year":"2012","unstructured":"Dong B et al (2012) TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. Am J Physiol Heart Circ Physiol 303:H732\u2013H742. https:\/\/doi.org\/10.1152\/ajpheart.00948.2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1957_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.4022\/jafib.535","volume":"5","author":"R Ducas","year":"2013","unstructured":"Ducas R, Ariyarajah V (2013) Atrial fibrillation in patients with ischemic and non-ischemic left ventricular dysfunction. J Atrial Fibrillation 5:535. https:\/\/doi.org\/10.4022\/jafib.535","journal-title":"J Atrial Fibrillation"},{"key":"1957_CR26","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3389\/fendo.2018.00642","volume":"9","author":"S Ducheix","year":"2018","unstructured":"Ducheix S, Magre J, Cariou B, Prieur X (2018) Chronic O-glcnacylation and diabetic cardiomyopathy: the bitterness of glucose. Front Endocrinol 9:642. https:\/\/doi.org\/10.3389\/fendo.2018.00642","journal-title":"Front Endocrinol"},{"key":"1957_CR27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3727\/105221618X15216453076707","volume":"18","author":"L Ehrlich","year":"2018","unstructured":"Ehrlich L et al (2018) alpha7-nAChR knockout mice decreases biliary hyperplasia and liver fibrosis in cholestatic bile duct-ligated mice. Gene Expr 18:197\u2013207. https:\/\/doi.org\/10.3727\/105221618X15216453076707","journal-title":"Gene Expr"},{"key":"1957_CR28","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1124\/jpet.117.245068","volume":"365","author":"EG El Nebrisi","year":"2018","unstructured":"El Nebrisi EG et al (2018) Curcumin acts as a positive allosteric modulator of alpha7-nicotinic acetylcholine receptors and reverses nociception in mouse models of inflammatory pain. J Pharmacol Exp Ther 365:190\u2013200. https:\/\/doi.org\/10.1124\/jpet.117.245068","journal-title":"J Pharmacol Exp Ther"},{"key":"1957_CR29","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/j.biopha.2018.10.026","volume":"108","author":"L Fan","year":"2018","unstructured":"Fan L et al (2018) CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4\/NF-kappaB pathway in STZ-induced diabetic mice. Biomed Pharmacother 108:1640\u20131650. https:\/\/doi.org\/10.1016\/j.biopha.2018.10.026","journal-title":"Biomed Pharmacother"},{"key":"1957_CR30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.yjmcc.2017.03.002","volume":"105","author":"B Feng","year":"2017","unstructured":"Feng B, Chen S, Gordon AD, Chakrabarti S (2017) miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes. J Mol Cell Cardiol 105:70\u201376. https:\/\/doi.org\/10.1016\/j.yjmcc.2017.03.002","journal-title":"J Mol Cell Cardiol"},{"key":"1957_CR31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/35092578","volume":"413","author":"KA Fitzgerald","year":"2001","unstructured":"Fitzgerald KA et al (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413:78\u201383. https:\/\/doi.org\/10.1038\/35092578","journal-title":"Nature"},{"key":"1957_CR32","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1172\/JCI6709","volume":"104","author":"S Frantz","year":"1999","unstructured":"Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT, Kelly RA (1999) Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 104:271\u2013280. https:\/\/doi.org\/10.1172\/JCI6709","journal-title":"J Clin Invest"},{"key":"1957_CR33","first-page":"4673","volume":"9","author":"Y Gao","year":"2017","unstructured":"Gao Y et al (2017) GTS-21 attenuates LPS-induced renal injury via the cholinergic anti-inflammatory pathway in mice. Am J Transl Res 9:4673\u20134681","journal-title":"Am J Transl Res"},{"key":"1957_CR34","doi-asserted-by":"publisher","first-page":"e0214942","DOI":"10.1371\/journal.pone.0214942","volume":"14","author":"BK Garg","year":"2019","unstructured":"Garg BK, Loring RH (2019) GTS-21 has cell-specific anti-inflammatory effects independent of alpha7 nicotinic acetylcholine receptors. PloS one 14:e0214942. https:\/\/doi.org\/10.1371\/journal.pone.0214942","journal-title":"PloS one"},{"key":"1957_CR35","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/dom.12944","volume":"19","author":"M Garg","year":"2017","unstructured":"Garg M et al (2017) Liraglutide acutely suppresses glucagon, lipolysis and ketogenesis in type 1 diabetes. Diabetes Obes Metab 19:1306\u20131311. https:\/\/doi.org\/10.1111\/dom.12944","journal-title":"Diabetes Obes Metab"},{"key":"1957_CR36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.bcp.2019.03.006","volume":"163","author":"V Gianello","year":"2019","unstructured":"Gianello V et al (2019) The PDE4 inhibitor CHF6001 modulates pro-inflammatory cytokines, chemokines and Th1- and Th17-polarizing cytokines in human dendritic cells. Biochem Pharmacol 163:371\u2013380. https:\/\/doi.org\/10.1016\/j.bcp.2019.03.006","journal-title":"Biochem Pharmacol"},{"key":"1957_CR37","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.phymed.2014.02.007","volume":"21","author":"C Guo","year":"2014","unstructured":"Guo C, Zhang C, Li L, Wang Z, Xiao W, Yang Z (2014) Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats. Phytomedicine 21:807\u2013814. https:\/\/doi.org\/10.1016\/j.phymed.2014.02.007","journal-title":"Phytomedicine"},{"key":"1957_CR38","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1093\/europace\/eun393","volume":"11","author":"M Haghjoo","year":"2009","unstructured":"Haghjoo M et al (2009) ST-segment depression as a risk factor in hypertrophic cardiomyopathy. Europace 11:643\u2013649. https:\/\/doi.org\/10.1093\/europace\/eun393","journal-title":"Europace"},{"key":"1957_CR39","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMoa1002659","volume":"363","author":"CY Ho","year":"2010","unstructured":"Ho CY et al (2010) Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy. N Engl J Med 363:552\u2013563. https:\/\/doi.org\/10.1056\/NEJMoa1002659","journal-title":"N Engl J Med"},{"key":"1957_CR40","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3389\/fphar.2019.00998","volume":"10","author":"N Hou","year":"2019","unstructured":"Hou N et al (2019) Carvacrol attenuates diabetic cardiomyopathy by modulating the PI3K\/AKT\/GLUT4 pathway in diabetic mice. Front Pharmacol 10:998. https:\/\/doi.org\/10.3389\/fphar.2019.00998","journal-title":"Front Pharmacol"},{"key":"1957_CR41","doi-asserted-by":"publisher","first-page":"325875","DOI":"10.1155\/2014\/325875","volume":"2014","author":"Hu","year":"2014","unstructured":"Hu, Liu R, Li J, Yue Y, Cheng W, Zhang P (2014) Attenuation of collagen-induced arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21. BioMed Res Int 2014:325875. https:\/\/doi.org\/10.1155\/2014\/325875","journal-title":"BioMed Res Int"},{"key":"1957_CR42","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.7150\/ijbs.27173","volume":"14","author":"X Huang","year":"2018","unstructured":"Huang X, Liu G, Guo J, Su Z (2018) The PI3K\/AKT pathway in obesity and type 2 diabetes. Int J Biol Sci 14:1483\u20131496. https:\/\/doi.org\/10.7150\/ijbs.27173","journal-title":"Int J Biol Sci"},{"key":"1957_CR43","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.2337\/diacare.23.8.1172","volume":"23","author":"N Iqbal","year":"2000","unstructured":"Iqbal N, Zayed M, Boden G (2000) Thalidomide impairs insulin action on glucose uptake and glycogen synthesis in patients with type 2 diabetes. Diabetes Care 23:1172\u20131176. https:\/\/doi.org\/10.2337\/diacare.23.8.1172","journal-title":"Diabetes Care"},{"key":"1957_CR44","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nrendo.2015.216","volume":"12","author":"G Jia","year":"2016","unstructured":"Jia G, DeMarco VG, Sowers JR (2016) Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol 12:144\u2013153. https:\/\/doi.org\/10.1038\/nrendo.2015.216","journal-title":"Nat Rev Endocrinol"},{"key":"1957_CR45","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s10020-019-0091-4","volume":"25","author":"T Jiang","year":"2019","unstructured":"Jiang T et al (2019) Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through alpha7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats. Mol Med 25:22. https:\/\/doi.org\/10.1186\/s10020-019-0091-4","journal-title":"Mol Med"},{"key":"1957_CR46","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/SHK.0000000000000729","volume":"47","author":"S Kashiwagi","year":"2017","unstructured":"Kashiwagi S et al (2017) Prevention of burn-induced inflammatory responses and muscle wasting by GTS-21, a specific agonist for alpha7 nicotinic acetylcholine receptors. Shock 47:61\u201369. https:\/\/doi.org\/10.1097\/SHK.0000000000000729","journal-title":"Shock"},{"key":"1957_CR47","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/cns.12758","volume":"23","author":"P Ke","year":"2017","unstructured":"Ke P, Shao BZ, Xu ZQ, Chen XW, Wei W, Liu C (2017) Activating alpha7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of beta-arrestin-1. CNS Neurosci Ther 23:875\u2013884. https:\/\/doi.org\/10.1111\/cns.12758","journal-title":"CNS Neurosci Ther"},{"key":"1957_CR48","doi-asserted-by":"publisher","first-page":"221.229","DOI":"10.4049\/jimmunol.198.Supp.221.9","volume":"198","author":"M Kha","year":"2017","unstructured":"Kha M, Chow S, Cameron DJ, O\u2019Barr SA (2017) Alpha-7 nicotinic acetylcholine receptor agonist GTS-21 influences the inflammatory response in an animal model of heart failure. J Immunol 198:221.229\u2013221.229","journal-title":"J Immunol"},{"key":"1957_CR49","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/s0735-6757(99)90128-6","volume":"17","author":"IA Khan","year":"1999","unstructured":"Khan IA, Ajatta FO, Ansari AW (1999) Persistent ST segment elevation: a new ECG finding in hypertrophic cardiomyopathy. Am J Emerg Med 17:296\u2013299. https:\/\/doi.org\/10.1016\/s0735-6757(99)90128-6","journal-title":"Am J Emerg Med"},{"key":"1957_CR50","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/jdi.12964","volume":"10","author":"K Kimura","year":"2019","unstructured":"Kimura K, Inaba Y, Watanabe H, Matsukawa T, Matsumoto M, Inoue H (2019) Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis. J Diabetes Investig 10:659\u2013666. https:\/\/doi.org\/10.1111\/jdi.12964","journal-title":"J Diabetes Investig"},{"key":"1957_CR51","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/sj.npp.1300028","volume":"28","author":"H Kitagawa","year":"2003","unstructured":"Kitagawa H, Takenouchi T, Azuma R, Wesnes KA, Kramer WG, Clody DE, Burnett AL (2003) Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology 28:542\u2013551. https:\/\/doi.org\/10.1038\/sj.npp.1300028","journal-title":"Neuropsychopharmacology"},{"key":"1957_CR52","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1007\/s10753-018-0759-x","volume":"41","author":"W Kong","year":"2018","unstructured":"Kong W et al (2018) GTS-21 protected against LPS-induced Sepsis myocardial injury in mice through alpha7nAChR. Inflammation 41:1073\u20131083. https:\/\/doi.org\/10.1007\/s10753-018-0759-x","journal-title":"Inflammation"},{"key":"1957_CR53","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.bcp.2009.06.096","volume":"78","author":"M Kox","year":"2009","unstructured":"Kox M, van Velzen JF, Pompe JC, Hoedemaekers CW, van der Hoeven JG, Pickkers P (2009) GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation. Biochem Pharmacol 78:863\u2013872. https:\/\/doi.org\/10.1016\/j.bcp.2009.06.096","journal-title":"Biochem Pharmacol"},{"key":"1957_CR54","doi-asserted-by":"publisher","first-page":"e008032","DOI":"10.1161\/JAHA.117.008032","volume":"7","author":"D Kraus","year":"2018","unstructured":"Kraus D, von Jeinsen B, Tzikas S, Palapies L, Zeller T, Bickel C, Fette G, Lackner KJ, Drechsler C, Neumann JT, Baldus S, Blankenberg S, M\u00fcnzel T, Wanner C, Zeiher AM, Keller T (2018) Cardiac troponins for the diagnosis of acute myocardial infarction in chronic kidney disease. J Am Heart Assoc 7:e008032. https:\/\/doi.org\/10.1161\/JAHA.117.008032","journal-title":"J Am Heart Assoc"},{"key":"1957_CR55","doi-asserted-by":"publisher","first-page":"4087632","DOI":"10.1155\/2016\/4087632","volume":"2016","author":"J Krejci","year":"2016","unstructured":"Krejci J, Mlejnek D, Sochorova D, Nemec P (2016) Inflammatory cardiomyopathy: a current view on the pathophysiology, diagnosis, and treatment. BioMed Res Int 2016:4087632\u20134087611. https:\/\/doi.org\/10.1155\/2016\/4087632","journal-title":"BioMed Res Int"},{"key":"1957_CR56","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/BF00167110","volume":"40","author":"N Le Novere","year":"1995","unstructured":"Le Novere N, Changeux JP (1995) Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J Mol Evol 40:155\u2013172","journal-title":"J Mol Evol"},{"key":"1957_CR57","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/s0002-8703(97)70245-x","volume":"133","author":"M Lee","year":"1997","unstructured":"Lee M et al (1997) Diabetes mellitus and echocardiographic left ventricular function in free-living elderly men and women: the Cardiovascular Health Study. Am Heart J 133:36\u201343. https:\/\/doi.org\/10.1016\/s0002-8703(97)70245-x","journal-title":"Am Heart J"},{"key":"1957_CR58","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pnpbp.2017.01.001","volume":"75","author":"AS Lewis","year":"2017","unstructured":"Lewis AS, van Schalkwyk GI, Bloch MH (2017) Alpha-7 nicotinic agonists for cognitive deficits in neuropsychiatric disorders: a translational meta-analysis of rodent and human studies. Progress Neuropsychopharmacol Biol Psychiatry 75:45\u201353. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.01.001","journal-title":"Progress Neuropsychopharmacol Biol Psychiatry"},{"key":"1957_CR59","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1159\/000329982","volume":"27","author":"Q Li","year":"2011","unstructured":"Li Q, Zhou XD, Kolosov VP, Perelman JM (2011) Nicotine reduces TNF-alpha expression through a alpha7 nAChR\/MyD88\/NF-kB pathway in HBE16 airway epithelial cells. Cell Physiol Biochem 27:605\u2013612. https:\/\/doi.org\/10.1159\/000329982","journal-title":"Cell Physiol Biochem"},{"key":"1957_CR60","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.metabol.2017.11.002","volume":"79","author":"Li","year":"2018","unstructured":"Li et al (2018) Nicotinic acetylcholine receptor alpha7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease. Metabolism 79:52\u201363. https:\/\/doi.org\/10.1016\/j.metabol.2017.11.002","journal-title":"Metabolism"},{"key":"1957_CR61","doi-asserted-by":"publisher","first-page":"4746","DOI":"10.1111\/jcmm.14363","volume":"23","author":"ZH Lin","year":"2019","unstructured":"Lin ZH et al (2019) Eliciting alpha7-nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling. J Cell Mol Med 23:4746\u20134758. https:\/\/doi.org\/10.1111\/jcmm.14363","journal-title":"J Cell Mol Med"},{"key":"1957_CR62","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s12026-017-8901-7","volume":"65","author":"Z Liu","year":"2017","unstructured":"Liu Z, Wang X, Wang Y, Zhao M (2017) NLRP3 inflammasome activation regulated by NF-kappaB and DAPK contributed to paraquat-induced acute kidney injury. Immunol Res 65:687\u2013698. https:\/\/doi.org\/10.1007\/s12026-017-8901-7","journal-title":"Immunol Res"},{"key":"1957_CR63","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","volume":"42","author":"YC Lu","year":"2008","unstructured":"Lu YC, Yeh WC, Ohashi PS (2008) LPS\/TLR4 signal transduction pathway. Cytokine 42:145\u2013151. https:\/\/doi.org\/10.1016\/j.cyto.2008.01.006","journal-title":"Cytokine"},{"key":"1957_CR64","doi-asserted-by":"publisher","first-page":"350","DOI":"10.2119\/molmed.2013.00117","volume":"20","author":"B Lu","year":"2014","unstructured":"Lu B et al (2014) alpha7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release. Mol Med 20:350\u2013358. https:\/\/doi.org\/10.2119\/molmed.2013.00117","journal-title":"Mol Med"},{"key":"1957_CR65","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/cvr\/cvp305","volume":"85","author":"N Mariappan","year":"2010","unstructured":"Mariappan N, Elks CM, Sriramula S, Guggilam A, Liu Z, Borkhsenious O, Francis J (2010) NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc Res 85:473\u2013483. https:\/\/doi.org\/10.1093\/cvr\/cvp305","journal-title":"Cardiovasc Res"},{"key":"1957_CR66","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/jpet.109.154633","volume":"332","author":"MB Marrero","year":"2010","unstructured":"Marrero MB, Lucas R, Salet C, Hauser TA, Mazurov A, Lippiello PM, Bencherif M (2010) An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes. J Pharmacol Exp Ther 332:173\u2013180. https:\/\/doi.org\/10.1124\/jpet.109.154633","journal-title":"J Pharmacol Exp Ther"},{"key":"1957_CR67","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s11357-012-9428-4","volume":"35","author":"E Marzetti","year":"2013","unstructured":"Marzetti E et al (2013) Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age 35:1061\u20131075. https:\/\/doi.org\/10.1007\/s11357-012-9428-4","journal-title":"Age"},{"key":"1957_CR68","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.3892\/or.2018.6616","volume":"40","author":"Z Mei","year":"2018","unstructured":"Mei Z et al (2018) Alpha7nAchR agonist GTS21 reduces radiationinduced lung injury. Oncol Rep 40:2287\u20132297. https:\/\/doi.org\/10.3892\/or.2018.6616","journal-title":"Oncol Rep"},{"key":"1957_CR69","doi-asserted-by":"publisher","first-page":"243","DOI":"10.12865\/CHSJ.44.03.07","volume":"44","author":"R Mitrut","year":"2018","unstructured":"Mitrut R, Stepan AE, Pirici D (2018) Histopathological aspects of the myocardium in dilated cardiomyopathy. Curr Health Sci J 44:243\u2013249. https:\/\/doi.org\/10.12865\/CHSJ.44.03.07","journal-title":"Curr Health Sci J"},{"key":"1957_CR70","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","volume":"15","author":"M Nakamura","year":"2018","unstructured":"Nakamura M, Sadoshima J (2018) Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol 15:387\u2013407. https:\/\/doi.org\/10.1038\/s41569-018-0007-y","journal-title":"Nat Rev Cardiol"},{"key":"1957_CR71","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ahj.2016.09.002","volume":"184","author":"JD Newman","year":"2017","unstructured":"Newman JD et al (2017) Diabetes mellitus is a coronary heart disease risk equivalent for peripheral vascular disease. Am Heart J 184:114\u2013120. https:\/\/doi.org\/10.1016\/j.ahj.2016.09.002","journal-title":"Am Heart J"},{"key":"1957_CR72","doi-asserted-by":"publisher","first-page":"281.281","DOI":"10.1096\/fasebj.2018.32.1_supplement.281.1","volume":"32","author":"NA Nolan","year":"2018","unstructured":"Nolan NA, Robateau Z, Brown KC, Chen YC, Egleton RD, Tirona MR, Dasgupta P (2018) Memantine (a dual \u03b17-nAChR\/NMDAR antagonist) displays anti-angiogenic activity in human squamous cell lung cancer. FASEB J 32:281.281\u2013281.281. https:\/\/doi.org\/10.1096\/fasebj.2018.32.1_supplement.281.1","journal-title":"FASEB J"},{"key":"1957_CR73","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.dsx.2017.12.001","volume":"12","author":"EP Odum","year":"2018","unstructured":"Odum EP, Young EE (2018) Elevated cardiac troponin I, creatine kinase and myoglobin and their relationship with cardiovascular risk factors in patients with type 2 diabetes. Diabetes Metab Syndr 12:141\u2013145. https:\/\/doi.org\/10.1016\/j.dsx.2017.12.001","journal-title":"Diabetes Metab Syndr"},{"key":"1957_CR74","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00592-016-0949-7","volume":"54","author":"TJ Orchard","year":"2017","unstructured":"Orchard TJ, Costacou T (2017) Cardiovascular complications of type 1 diabetes: update on the renal link. Acta Diabetol 54:325\u2013334. https:\/\/doi.org\/10.1007\/s00592-016-0949-7","journal-title":"Acta Diabetol"},{"key":"1957_CR75","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1093\/europace\/euv380","volume":"18","author":"J Paavola","year":"2016","unstructured":"Paavola J et al (2016) Slowed depolarization and irregular repolarization in catecholaminergic polymorphic ventricular tachycardia: a study from cellular Ca2+ transients and action potentials to clinical monophasic action potentials and electrocardiography. Europace 18:1599\u20131607. https:\/\/doi.org\/10.1093\/europace\/euv380","journal-title":"Europace"},{"key":"1957_CR76","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1210\/en.2017-00294","volume":"158","author":"PB Pal","year":"2017","unstructured":"Pal PB, Sonowal H, Shukla K, Srivastava SK, Ramana KV (2017) Aldose Reductase mediates NLRP3 inflammasome-initiated innate immune response in hyperglycemia-induced Thp1 monocytes and male mice. Endocrinology 158:3661\u20133675. https:\/\/doi.org\/10.1210\/en.2017-00294","journal-title":"Endocrinology"},{"key":"1957_CR77","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1365-2567.2004.01976.x","volume":"113","author":"EM Palsson-McDermott","year":"2004","unstructured":"Palsson-McDermott EM, O'Neill LA (2004) Signal transduction by the lipopolysaccharide receptor, toll-like receptor-4. Immunology 113:153\u2013162. https:\/\/doi.org\/10.1111\/j.1365-2567.2004.01976.x","journal-title":"Immunology"},{"key":"1957_CR78","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1017\/cem.2017.409","volume":"20","author":"CJ Parr","year":"2018","unstructured":"Parr CJ, Sharma R, Garber PJ (2018) Apical hypertrophic cardiomyopathy treated as ST-elevation myocardial infarction. CJEM 20:S51\u2013S55. https:\/\/doi.org\/10.1017\/cem.2017.409","journal-title":"CJEM"},{"key":"1957_CR79","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/ehjci\/jey135","volume":"20","author":"B Raman","year":"2019","unstructured":"Raman B et al (2019) Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications. Eur Heart J Cardiovasc Imaging 20:157\u2013167. https:\/\/doi.org\/10.1093\/ehjci\/jey135","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1957_CR80","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.3390\/ijms13055751","volume":"13","author":"H Raza","year":"2012","unstructured":"Raza H, John A (2012) Streptozotocin-induced cytotoxicity, oxidative stress and mitochondrial dysfunction in human hepatoma HepG2 cells. Int J Mol Sci 13:5751\u20135767. https:\/\/doi.org\/10.3390\/ijms13055751","journal-title":"Int J Mol Sci"},{"key":"1957_CR81","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s42269-018-0020-7","volume":"42","author":"S Saber","year":"2018","unstructured":"Saber S (2018) Angiotensin II: a key mediator in the development of liver fibrosis and cancer. Bull Natl Res Centre 42:18. https:\/\/doi.org\/10.1186\/s42269-018-0020-7","journal-title":"Bull Natl Res Centre"},{"key":"1957_CR82","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1007\/s00210-019-01706-2","volume":"392","author":"S Saber","year":"2019","unstructured":"Saber S et al (2019) Telmisartan attenuates N-nitrosodiethylamine-induced hepatocellular carcinoma in mice by modulating the NF-kappaB-TAK1-ERK1\/2 axis in the context of PPARgamma agonistic activity. Naunyn Schmiedebergs Arch Pharmacol 392:1591\u20131604. https:\/\/doi.org\/10.1007\/s00210-019-01706-2","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1957_CR83","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s00424-018-2180-6","volume":"470","author":"SJ Schaller","year":"2018","unstructured":"Schaller SJ et al (2018) GTS-21 attenuates loss of body mass, muscle mass, and function in rats having systemic inflammation with and without disuse atrophy. Pflugers Archiv 470:1647\u20131657. https:\/\/doi.org\/10.1007\/s00424-018-2180-6","journal-title":"Pflugers Archiv"},{"key":"1957_CR84","doi-asserted-by":"publisher","first-page":"859","DOI":"10.3233\/JAD-150963","volume":"50","author":"S Shi","year":"2016","unstructured":"Shi S et al (2016) Gx-50 inhibits neuroinflammation via alpha7 nAChR activation of the JAK2\/STAT3 and PI3K\/AKT pathways. J Alzheimers Dis 50:859\u2013871. https:\/\/doi.org\/10.3233\/JAD-150963","journal-title":"J Alzheimers Dis"},{"key":"1957_CR85","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1476-5381.2010.00699.x","volume":"160","author":"SA Snoek","year":"2010","unstructured":"Snoek SA et al (2010) Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. Br J Pharmacol 160:322\u2013333. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00699.x","journal-title":"Br J Pharmacol"},{"key":"1957_CR86","doi-asserted-by":"publisher","first-page":"412","DOI":"10.2337\/dc16-2641","volume":"40","author":"SD Solomon","year":"2017","unstructured":"Solomon SD et al (2017) Diabetic retinopathy: a position statement by the American Diabetes Association. Diabetes Care 40:412\u2013418. https:\/\/doi.org\/10.2337\/dc16-2641","journal-title":"Diabetes Care"},{"key":"1957_CR87","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3389\/fimmu.2019.00565","volume":"10","author":"ACP Souza","year":"2019","unstructured":"Souza ACP et al (2019) Short-term high-fat diet consumption reduces hypothalamic expression of the nicotinic acetylcholine receptor alpha7 subunit (alpha7nAChR) and affects the anti-inflammatory response in a mouse model of sepsis. Front Immunol 10:565. https:\/\/doi.org\/10.3389\/fimmu.2019.00565","journal-title":"Front Immunol"},{"key":"1957_CR88","doi-asserted-by":"publisher","first-page":"154002","DOI":"10.1016\/j.metabol.2019.154002","volume":"102","author":"Y Sun","year":"2020","unstructured":"Sun Y et al (2020) Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function. Metabolism 102:154002. https:\/\/doi.org\/10.1016\/j.metabol.2019.154002","journal-title":"Metabolism"},{"key":"1957_CR89","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.neurobiolaging.2017.10.021","volume":"62","author":"K Takata","year":"2018","unstructured":"Takata K et al (2018) Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Abeta accumulation through suppression of neuronal gamma-secretase activity and promotion of microglial amyloid-beta phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer\u2019s disease. Neurobiol Aging 62:197\u2013209. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.10.021","journal-title":"Neurobiol Aging"},{"key":"1957_CR90","doi-asserted-by":"publisher","unstructured":"Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L (2020) Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol. https:\/\/doi.org\/10.1038\/s41569-020-0339-2","DOI":"10.1038\/s41569-020-0339-2"},{"key":"1957_CR91","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1016\/j.bbadis.2015.07.015","volume":"1852","author":"A Tao","year":"2015","unstructured":"Tao A et al (2015) Cardiomyocyte-fibroblast interaction contributes to diabetic cardiomyopathy in mice: role of HMGB1\/TLR4\/IL-33 axis. Biochim Biophys Acta 1852:2075\u20132085. https:\/\/doi.org\/10.1016\/j.bbadis.2015.07.015","journal-title":"Biochim Biophys Acta"},{"key":"1957_CR92","doi-asserted-by":"publisher","first-page":"H1036","DOI":"10.1152\/ajpheart.00340.2014","volume":"307","author":"CM Thomas","year":"2014","unstructured":"Thomas CM et al (2014) Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system. Am J Physiol Heart Circ Physiol 307:H1036\u2013H1045. https:\/\/doi.org\/10.1152\/ajpheart.00340.2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1957_CR93","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1017\/S0033583510000168","volume":"43","author":"AJ Thompson","year":"2010","unstructured":"Thompson AJ, Lester HA, Lummis SC (2010) The structural basis of function in Cys-loop receptors. Q Rev Biophys 43:449\u2013499. https:\/\/doi.org\/10.1017\/S0033583510000168","journal-title":"Q Rev Biophys"},{"key":"1957_CR94","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1677\/joe.0.0690455","volume":"69","author":"H Tjalve","year":"1976","unstructured":"Tjalve H, Wilander E, Johansson EB (1976) Distribution of labelled streptozotocin in mice: uptake and retention in pancreatic islets. J Endocrinol 69:455\u2013456. https:\/\/doi.org\/10.1677\/joe.0.0690455","journal-title":"J Endocrinol"},{"key":"1957_CR95","doi-asserted-by":"publisher","first-page":"3558","DOI":"10.1096\/fj.14-262493","volume":"29","author":"LD Truong","year":"2015","unstructured":"Truong LD, Trostel J, Garcia GE (2015) Absence of nicotinic acetylcholine receptor alpha7 subunit amplifies inflammation and accelerates onset of fibrosis: an inflammatory kidney model. FASEB J 29:3558\u20133570. https:\/\/doi.org\/10.1096\/fj.14-262493","journal-title":"FASEB J"},{"key":"1957_CR96","doi-asserted-by":"publisher","first-page":"L748","DOI":"10.1152\/ajplung.00393.2016","volume":"312","author":"A Vang","year":"2017","unstructured":"Vang A et al (2017) Effect of alpha7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure American journal of physiology. Lung Cell Mol Physiol 312:L748\u2013L759. https:\/\/doi.org\/10.1152\/ajplung.00393.2016","journal-title":"Lung Cell Mol Physiol"},{"key":"1957_CR97","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fimmu.2014.00316","volume":"5","author":"C Vaure","year":"2014","unstructured":"Vaure C, Liu Y (2014) A comparative review of toll-like receptor 4 expression and functionality in different animal species. Front Immunol 5:316. https:\/\/doi.org\/10.3389\/fimmu.2014.00316","journal-title":"Front Immunol"},{"key":"1957_CR98","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s003950050007","volume":"95","author":"S Villegas","year":"2000","unstructured":"Villegas S, Villarreal FJ, Dillmann WH (2000) Leukemia inhibitory factor and interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes. Basic Res Cardiol 95:47\u201354. https:\/\/doi.org\/10.1007\/s003950050007","journal-title":"Basic Res Cardiol"},{"key":"1957_CR99","doi-asserted-by":"publisher","first-page":"13997","DOI":"10.1038\/ncomms13997","volume":"8","author":"Wang","year":"2017","unstructured":"Wang et al (2017) Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2. Nat Commun 8:13997. https:\/\/doi.org\/10.1038\/ncomms13997","journal-title":"Nat Commun"},{"key":"1957_CR100","doi-asserted-by":"publisher","first-page":"110965","DOI":"10.1016\/j.fct.2019.110965","volume":"135","author":"Wang","year":"2020","unstructured":"Wang, He Y, Yu D, Jin L, Gong X, Zhang B (2020) Perilla oil regulates intestinal microbiota and alleviates insulin resistance through the PI3K\/AKT signaling pathway in type-2 diabetic KKAy mice. Food Chem Toxicol 135:110965. https:\/\/doi.org\/10.1016\/j.fct.2019.110965","journal-title":"Food Chem Toxicol"},{"key":"1957_CR101","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1080\/14728222.2019.1624721","volume":"23","author":"AM Warren","year":"2019","unstructured":"Warren AM, Knudsen ST, Cooper ME (2019) Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies. Expert Opin Ther Targets 23:579\u2013591. https:\/\/doi.org\/10.1080\/14728222.2019.1624721","journal-title":"Expert Opin Ther Targets"},{"key":"1957_CR102","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1161\/JAHA.117.006510","volume":"6","author":"SJ Wu","year":"2017","unstructured":"Wu SJ, Li YC, Shi ZW, Lin ZH, Rao ZH, Tai SC, Chu MP, Li L, Lin JF (2017) Alteration of cholinergic anti-inflammatory pathway in rat with ischemic cardiomyopathy-modified electrophysiological function of heart. J Am Heart Assoc 6:6. https:\/\/doi.org\/10.1161\/JAHA.117.006510","journal-title":"J Am Heart Assoc"},{"key":"1957_CR103","doi-asserted-by":"publisher","first-page":"155019","DOI":"10.1016\/j.cyto.2020.155019","volume":"128","author":"Wu","year":"2020","unstructured":"Wu et al (2020) GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through alpha7nAchRs in mice. Cytokine 128:155019. https:\/\/doi.org\/10.1016\/j.cyto.2020.155019","journal-title":"Cytokine"},{"key":"1957_CR104","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1111\/1440-1681.12819","volume":"44","author":"YH Yang","year":"2017","unstructured":"Yang YH et al (2017) Specific alpha7 nicotinic acetylcholine receptor agonist ameliorates isoproterenol-induced cardiac remodelling in mice through TGF-beta1\/Smad3 pathway. Clin Exp Pharmacol Physiol 44:1192\u20131200. https:\/\/doi.org\/10.1111\/1440-1681.12819","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1957_CR105","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/imm.13056","volume":"157","author":"Q Yang","year":"2019","unstructured":"Yang Q, Liu R, Yu Q, Bi Y, Liu G (2019) Metabolic regulation of inflammasomes in inflammation. Immunology 157:95\u2013109. https:\/\/doi.org\/10.1111\/imm.13056","journal-title":"Immunology"},{"key":"1957_CR106","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1111\/jcmm.14146","volume":"23","author":"L Yin","year":"2019","unstructured":"Yin L et al (2019) FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC beta2 pathway. J Cell Mol Med 23:2558\u20132567. https:\/\/doi.org\/10.1111\/jcmm.14146","journal-title":"J Cell Mol Med"},{"key":"1957_CR107","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/j.ijbiomac.2017.03.124","volume":"105","author":"C Ying","year":"2017","unstructured":"Ying C, Mao Y, Chen L, Wang S, Ling H, Li W, Zhou X (2017) Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats. Int J Biol Macromol 105:1587\u20131594. https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.03.124","journal-title":"Int J Biol Macromol"},{"key":"1957_CR108","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1365-2249.2006.03169.x","volume":"146","author":"H Yoshikawa","year":"2006","unstructured":"Yoshikawa H et al (2006) Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7. Clin Exp Immunol 146:116\u2013123. https:\/\/doi.org\/10.1111\/j.1365-2249.2006.03169.x","journal-title":"Clin Exp Immunol"},{"key":"1957_CR109","doi-asserted-by":"publisher","first-page":"679.671","DOI":"10.1096\/fasebj.2019.33.1_supplement.679.1","volume":"33","author":"ME Youssef","year":"2019","unstructured":"Youssef ME, El-Mas MM, Abdelrazek HM, El-Azab MF (2019) \u03b17-nAChR-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats. FASEB J 33:679.671. https:\/\/doi.org\/10.1096\/fasebj.2019.33.1_supplement.679.1","journal-title":"FASEB J"},{"key":"1957_CR110","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.3892\/mmr.2017.6456","volume":"15","author":"Yu","year":"2017","unstructured":"Yu, Zheng G (2017) Troxerutin protects against diabetic cardiomyopathy through NFkappaB\/AKT\/IRS1 in a rat model of type 2 diabetes. Mol Med Rep 15:3473\u20133478. https:\/\/doi.org\/10.3892\/mmr.2017.6456","journal-title":"Mol Med Rep"},{"key":"1957_CR111","doi-asserted-by":"publisher","first-page":"16304","DOI":"10.1074\/jbc.M212321200","volume":"278","author":"Yu","year":"2003","unstructured":"Yu, Kennedy RH, Liu SJ (2003) JAK2\/STAT3, not ERK1\/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes. J Biol Chem 278:16304\u201316309. https:\/\/doi.org\/10.1074\/jbc.M212321200","journal-title":"J Biol Chem"},{"key":"1957_CR112","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/01.shk.0000225404.51320.82","volume":"26","author":"M Yu","year":"2006","unstructured":"Yu M et al (2006) HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 26:174\u2013179. https:\/\/doi.org\/10.1097\/01.shk.0000225404.51320.82","journal-title":"Shock"},{"key":"1957_CR113","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.intimp.2015.10.005","volume":"29","author":"Y Yue","year":"2015","unstructured":"Yue Y et al (2015) GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-kappaB signaling pathway through the alpha7 nicotinic acetylcholine receptor. Int Immunopharmacol 29:504\u2013512. https:\/\/doi.org\/10.1016\/j.intimp.2015.10.005","journal-title":"Int Immunopharmacol"},{"key":"1957_CR114","doi-asserted-by":"publisher","first-page":"e918617","DOI":"10.12659\/MSM.918617","volume":"26","author":"Y Zhai","year":"2020","unstructured":"Zhai Y, Zhu Y, Liu J, Xie K, Yu J, Yu L, Deng H (2020) Dexmedetomidine post-conditioning alleviates cerebral ischemia-reperfusion injury in rats by inhibiting high mobility group protein B1 group (HMGB1)\/toll-like receptor 4 (TLR4)\/nuclear factor kappa B (NF-kappaB) signaling pathway. Med Sci Monit 26:e918617. https:\/\/doi.org\/10.12659\/MSM.918617","journal-title":"Med Sci Monit"},{"key":"1957_CR115","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/1479-5876-8-133","volume":"8","author":"Zhang","year":"2010","unstructured":"Zhang et al (2010) Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of Toll-like receptor-4. J Transl Med 8:133. https:\/\/doi.org\/10.1186\/1479-5876-8-133","journal-title":"J Transl Med"},{"key":"1957_CR116","doi-asserted-by":"publisher","first-page":"23010","DOI":"10.1038\/srep23010","volume":"6","author":"Zhang","year":"2016","unstructured":"Zhang et al (2016) Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFbeta1 and miR-29 pathways. Sci Rep 6:23010. https:\/\/doi.org\/10.1038\/srep23010","journal-title":"Sci Rep"},{"key":"1957_CR117","first-page":"971","volume":"9","author":"LY Zhang","year":"2017","unstructured":"Zhang LY, Bian H, Guo L, Zhu H (2017) Activation of the alpha7 nicotinic receptor promotes lipopolysaccharide-induced conversion of M1 microglia to M2. Am J Transl Res 9:971\u2013985","journal-title":"Am J Transl Res"},{"key":"1957_CR118","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1080\/22953337.1985.11719096","volume":"40","author":"D Zolenko","year":"1985","unstructured":"Zolenko D, Gaillard M, Vandenbosch R, Daenen G (1985) Pneumatosis cystoides intestinalis. Acta Clin Belg 40:292\u2013297","journal-title":"Acta Clin Belg"}],"updated-by":[{"DOI":"10.1007\/s00210-026-05995-2","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000}}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01957-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01957-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01957-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:45:19Z","timestamp":1792039519000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01957-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,10]]},"references-count":118,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["1957"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-01957-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,10]]},"assertion":[{"value":"20 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00210-026-05995-2","URL":"https:\/\/doi.org\/10.1007\/s00210-026-05995-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted under the approval of animal care committee guidelines, Suez Canal University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}