{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:26:10Z","timestamp":1772857570827,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00210-020-01973-4","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T04:11:44Z","timestamp":1600402304000},"page":"279-289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Raptinal silver nanoparticles: new therapeutic advances in hepatocellular carcinoma mouse model"],"prefix":"10.1007","volume":"394","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-9763","authenticated-orcid":false,"given":"Heba","family":"Taha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nourhan","family":"Elfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Haffez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeineb A.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"1973_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.msec.2018.08.027","volume":"93","author":"E Ahmadian","year":"2018","unstructured":"Ahmadian E, Dizaj SM, Rahimpour E, Hasanzadeh A, Eftekhari A, Hosain zadegan H et al (2018) Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line. Mater Sci Eng C 93:465\u2013471. https:\/\/doi.org\/10.1016\/j.msec.2018.08.027","journal-title":"Mater Sci Eng C"},{"issue":"4","key":"1973_CR2","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1016\/j.jksus.2020.04.002","volume":"32","author":"AA Al-kawmani","year":"2020","unstructured":"Al-kawmani AA, Alanazi KM, Farah MA, Ali MA, Hailan WAQ, Al-Hemaid FMA (2020) Apoptosis-inducing potential of biosynthesized silver nanoparticles in breast cancer cells. J King Saud Univ Sci 32(4):2480\u20132488. https:\/\/doi.org\/10.1016\/j.jksus.2020.04.002","journal-title":"J King Saud Univ Sci"},{"issue":"1","key":"1973_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-12834-1","volume":"7","author":"DS Bai","year":"2017","unstructured":"Bai DS, Zhang C, Chen P, Jin SJ, Jiang GQ (2017) The prognostic correlation of AFP level at diagnosis with pathological grade, progression, and survival of patients with hepatocellular carcinoma. Sci Rep 7(1):1\u20139. https:\/\/doi.org\/10.1038\/s41598-017-12834-1","journal-title":"Sci Rep"},{"issue":"8","key":"1973_CR4","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1093\/carcin\/bgp331","volume":"31","author":"DK Broz","year":"2010","unstructured":"Broz DK, Attardi LD (2010) In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis 31(8):1311\u20131318. https:\/\/doi.org\/10.1093\/carcin\/bgp331","journal-title":"Carcinogenesis"},{"issue":"2","key":"1973_CR5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1053\/j.seminoncol.2014.03.006","volume":"41","author":"BI Carr","year":"2014","unstructured":"Carr BI, Guerra V, Giannini EG, Farinati F, Ciccarese F, Ludovico Rapaccini G et al (2014) Association of abnormal plasma bilirubin with aggressive hepatocellular carcinoma phenotype. Semin Oncol 41(2):252\u2013258. https:\/\/doi.org\/10.1053\/j.seminoncol.2014.03.006","journal-title":"Semin Oncol"},{"issue":"sup1","key":"1973_CR6","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1080\/21691401.2018.1449118","volume":"46","author":"H Chugh","year":"2018","unstructured":"Chugh H, Sood D, Chandra I, Tomar V, Dhawan G, Chandra R (2018) Role of gold and silver nanoparticles in cancer nano-medicine. Artificial Cells Nanomed Biotechnol 46(sup1):1210\u20131220. https:\/\/doi.org\/10.1080\/21691401.2018.1449118","journal-title":"Artificial Cells Nanomed Biotechnol"},{"issue":"6","key":"1973_CR7","first-page":"670","volume":"52","author":"A Columbano","year":"1985","unstructured":"Columbano A, Ledda-Columbano GM, Coni PP, Faa G, Liguori C, Santa Cruz G, Pani P (1985) Occurrence of cell death (apoptosis) during the involution of liver hyperplasia. Lab Invest J Tech Meth Pathol 52(6):670\u2013675 Retrieved from http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4010225","journal-title":"Lab Invest J Tech Meth Pathol"},{"issue":"5","key":"1973_CR8","doi-asserted-by":"publisher","first-page":"787","DOI":"10.4254\/wjh.v7.i5.787","volume":"7","author":"G-L Deng","year":"2015","unstructured":"Deng G-L (2015) Chemotherapy and target therapy for hepatocellular carcinoma: new advances and challenges. World J Hepatol 7(5):787\u2013798. https:\/\/doi.org\/10.4254\/wjh.v7.i5.787","journal-title":"World J Hepatol"},{"issue":"1","key":"1973_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.etp.2014.09.005","volume":"67","author":"MM El Mahdy","year":"2015","unstructured":"El Mahdy MM, Eldin TAS, Aly HS, Mohammed FF, Shaalan MI (2015) Evaluation of hepatotoxic and genotoxic potential of silver nanoparticles in albino rats. Exp Toxicol Pathol 67(1):21\u201329. https:\/\/doi.org\/10.1016\/j.etp.2014.09.005","journal-title":"Exp Toxicol Pathol"},{"issue":"1\u20132","key":"1973_CR10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ijpharm.2017.06.044","volume":"529","author":"NS Farrag","year":"2017","unstructured":"Farrag NS, El-Sabagh HA, Al-mahallawi AM, Amin AM, AbdEl-Bary A, Mamdouh W (2017) Comparative study on radiolabeling and biodistribution of core-shell silver\/polymeric nanoparticles-based theranostics for tumor targeting. Int J Pharm 529(1\u20132):123\u2013133. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.06.044","journal-title":"Int J Pharm"},{"key":"1973_CR11","doi-asserted-by":"publisher","unstructured":"Fatemi M, Moshtaghian J, Ghaedi K, Dinani NJ (2017) Effects of silver nanoparticle on the developing liver of rat pups after maternal exposure. Iran J Pharmaceut Res. https:\/\/doi.org\/10.22037\/ijpr.2017.2020","DOI":"10.22037\/ijpr.2017.2020"},{"issue":"2","key":"1973_CR12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/PAS.0b013e3181805089","volume":"33","author":"G Goss","year":"2009","unstructured":"Goss G (2009) Theory and practice of histological techniques. Am J Surg Pathol 33(2):323. https:\/\/doi.org\/10.1097\/PAS.0b013e3181805089","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"1973_CR13","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3748\/wjg.v13.i7.985","volume":"13","author":"Y-S Guan","year":"2007","unstructured":"Guan Y-S (2007) p53 gene in treatment of hepatic carcinoma: status quo. World J Gastroenterol 13(7):985. https:\/\/doi.org\/10.3748\/wjg.v13.i7.985","journal-title":"World J Gastroenterol"},{"key":"1973_CR14","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.2147\/IJN.S111279","volume":"11","author":"S Gurunathan","year":"2016","unstructured":"Gurunathan S, Zhang X-F (2016) Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy. Int J Nanomedicine 11:3655\u20133675. https:\/\/doi.org\/10.2147\/IJN.S111279","journal-title":"Int J Nanomedicine"},{"issue":"49","key":"1973_CR15","doi-asserted-by":"publisher","first-page":"85599","DOI":"10.18632\/oncotarget.20343","volume":"8","author":"C He","year":"2017","unstructured":"He C, Zhang X, Li C, Peng W, Wen TF, Yan LN et al (2017) Changes of alpha-fetoprotein levels could predict recurrent hepatocellular carcinoma survival after trans-arterial chemoembolization. Oncotarget 8(49):85599\u201385611. https:\/\/doi.org\/10.18632\/oncotarget.20343","journal-title":"Oncotarget"},{"issue":"8","key":"1973_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-019-1790-z","volume":"10","author":"S Heimer","year":"2019","unstructured":"Heimer S, Knoll G, Schulze-Osthoff K, Ehrenschwender M (2019) Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis. Cell Death Dis 10(8):1\u201313. https:\/\/doi.org\/10.1038\/s41419-019-1790-z","journal-title":"Cell Death Dis"},{"key":"1973_CR17","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.80238","volume-title":"Nanomedicines","author":"N Ivanova","year":"2019","unstructured":"Ivanova N, Gugleva V, Dobreva M, Pehlivanov I, Stefanov S, Andonova V (2019) Silver nanoparticles as multi-functional drug delivery systems. In: Nanomedicines. https:\/\/doi.org\/10.5772\/intechopen.80238"},{"key":"1973_CR18","doi-asserted-by":"publisher","unstructured":"Kasprzak, A., & Adamek, A. (2018, December 1). Role of endoglin (CD105) in the progression of hepatocellular carcinoma and anti-angiogenic therapy. International Journal of Molecular Sciences, Vol. 19. https:\/\/doi.org\/10.3390\/ijms19123887","DOI":"10.3390\/ijms19123887"},{"key":"1973_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4290705","volume":"2018","author":"H Katas","year":"2018","unstructured":"Katas H, Moden NZ, Lim CS, Celesistinus T, Chan JY, Ganasan P, Suleman Ismail Abdalla S (2018) Biosynthesis and potential applications of silver and gold nanoparticles and their chitosan-based nanocomposites in nanomedicine. J Nanotechnol 2018:1\u201313. https:\/\/doi.org\/10.1155\/2018\/4290705","journal-title":"J Nanotechnol"},{"key":"1973_CR20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/B978-0-12-804274-8.00007-2","volume-title":"Liver Pathophysiology","author":"A Katoonizadeh","year":"2017","unstructured":"Katoonizadeh A (2017) Liver Regeneration. In: Liver Pathophysiology, pp 113\u2013123. https:\/\/doi.org\/10.1016\/B978-0-12-804274-8.00007-2"},{"issue":"9204","key":"1973_CR21","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0140-6736(99)00219-6","volume":"355","author":"MC Kew","year":"2000","unstructured":"Kew MC (2000) Serum aminotransferase concentration as evidence of hepatocellular damage. Lancet 355(9204):591\u2013592. https:\/\/doi.org\/10.1016\/S0140-6736(99)00219-6","journal-title":"Lancet"},{"issue":"1","key":"1973_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-9966-28-107","volume":"28","author":"YF Liu","year":"2009","unstructured":"Liu YF, Zha BS, Zhang HL, Zhu XJ, Li YH, Zhu J, Guan XH, Feng ZQ, Zhang JP (2009) Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. J Exp Clin Cancer Res 28(1):1\u201316. https:\/\/doi.org\/10.1186\/1756-9966-28-107","journal-title":"J Exp Clin Cancer Res"},{"key":"1973_CR23","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.2147\/IJN.S115473","volume":"11","author":"PD Liu","year":"2016","unstructured":"Liu PD, Jin H, Guo Z, Ma J, Zhao J, Li D, Wu H, Gu N (2016) Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma. Int J Nanomedicine 11:5003\u20135014. https:\/\/doi.org\/10.2147\/IJN.S115473","journal-title":"Int J Nanomedicine"},{"issue":"4","key":"1973_CR24","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3892\/ijo.2017.4105","volume":"51","author":"X Liu","year":"2017","unstructured":"Liu X, Xu J, Wang S, Yu X, Kou B, Chai M, Zang Y, Chen D (2017) Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo. Int J Oncol 51(4):1291\u20131299. https:\/\/doi.org\/10.3892\/ijo.2017.4105","journal-title":"Int J Oncol"},{"issue":"4","key":"1973_CR25","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","volume":"147","author":"T Luedde","year":"2014","unstructured":"Luedde T, Kaplowitz N, Schwabe RF (2014) Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology 147(4):765\u2013783.e4. https:\/\/doi.org\/10.1053\/j.gastro.2014.07.018","journal-title":"Gastroenterology"},{"issue":"1","key":"1973_CR26","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/1477-7819-11-212","volume":"11","author":"W Ma","year":"2013","unstructured":"Ma W, Wang H, Teng L (2013) Correlation analysis of preoperative serum alpha-fetoprotein (AFP) level and prognosis of hepatocellular carcinoma (HCC) after hepatectomy. World J Surg Oncol 11(1):212. https:\/\/doi.org\/10.1186\/1477-7819-11-212","journal-title":"World J Surg Oncol"},{"issue":"9","key":"1973_CR27","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1016\/j.celrep.2015.10.042","volume":"13","author":"R Palchaudhuri","year":"2015","unstructured":"Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ (2015) A small molecule that induces intrinsic pathway apoptosis with unparalleled speed. Cell Rep 13(9):2027\u20132036. https:\/\/doi.org\/10.1016\/j.celrep.2015.10.042","journal-title":"Cell Rep"},{"issue":"2","key":"1973_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4103\/0976-500X.72350","volume":"1","author":"S Parasuraman","year":"2010","unstructured":"Parasuraman S, Raveendran R, Kesavan R (2010) Blood sample collection in small laboratory animals. J Pharmacol Pharmacother 1(2):87\u201393. https:\/\/doi.org\/10.4103\/0976-500X.72350","journal-title":"J Pharmacol Pharmacother"},{"issue":"07\/2019","key":"1973_CR29","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.7754\/Clin.Lab.2019.181219","volume":"65","author":"A Radwan","year":"2019","unstructured":"Radwan A, Ismael O, Fawzy A, El-Mesallamy H (2019) Evaluation of serum integrin \u03b1v\u03b23 &amp; vitronectin in the early diagnosis of breast cancer. Clin Lab 65(07\/2019):1185\u20131193. https:\/\/doi.org\/10.7754\/Clin.Lab.2019.181219","journal-title":"Clin Lab"},{"issue":"3","key":"1973_CR30","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3390\/cancers12030664","volume":"12","author":"G Raja","year":"2020","unstructured":"Raja G, Jang Y-K, Suh J-S, Kim H-S, Ahn SH, Kim T-J (2020) Microcellular environmental regulation of silver nanoparticles in cancer therapy: a critical review. Cancers 12(3):664. https:\/\/doi.org\/10.3390\/cancers12030664","journal-title":"Cancers"},{"key":"1973_CR31","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1053\/j.gastro.2008.10.052","volume":"136","author":"CE Ruhl","year":"2009","unstructured":"Ruhl CE, Everhart JE (2009) Elevated serum alanine aminotransferase and \u03b3-glutamyltransferase and mortality in the United States population. Gastroenterology. 136:477\u2013485.e11. https:\/\/doi.org\/10.1053\/j.gastro.2008.10.052","journal-title":"Gastroenterology."},{"issue":"1","key":"1973_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3322\/caac.21208","volume":"64","author":"R Siegel","year":"2014","unstructured":"Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics, 2014. CA Cancer J Clin 64(1):9\u201329. https:\/\/doi.org\/10.3322\/caac.21208","journal-title":"CA Cancer J Clin"},{"key":"1973_CR33","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.toxrep.2018.02.013","volume":"5","author":"A Singh","year":"2018","unstructured":"Singh A, Dar MY, Joshi B, Sharma B, Shrivastava S, Shukla S (2018) Phytofabrication of silver nanoparticles: novel drug to overcome hepatocellular ailments. Toxicol Rep 5:333\u2013342. https:\/\/doi.org\/10.1016\/j.toxrep.2018.02.013","journal-title":"Toxicol Rep"},{"key":"1973_CR34","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.77075","volume-title":"Silver nanoparticles - fabrication, characterization and applications","author":"M Skonieczna","year":"2018","unstructured":"Skonieczna M, Hudy D (2018) Biological activity of silver nanoparticles and their applications in anticancer therapy. In: Silver nanoparticles - fabrication, characterization and applications. https:\/\/doi.org\/10.5772\/intechopen.77075"},{"key":"1973_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1177\/0023677215570086","volume":"49","author":"R Tolba","year":"2015","unstructured":"Tolba R, Kraus T, Liedtke C, Schwarz M, Weiskirchen R (2015) Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Lab Anim 49:59\u201369. https:\/\/doi.org\/10.1177\/0023677215570086","journal-title":"Lab Anim"},{"issue":"1","key":"1973_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/0471141755.ph1430s66","volume":"66","author":"T Uehara","year":"2014","unstructured":"Uehara T, Pogribny IP, Rusyn I (2014) The DEN and CCl 4 -induced mouse model of fibrosis and inflammation-associated hepatocellular carcinoma. Cur Protoc Pharmacol 66(1):1\u201310. https:\/\/doi.org\/10.1002\/0471141755.ph1430s66","journal-title":"Cur Protoc Pharmacol"},{"issue":"5","key":"1973_CR37","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1093\/carcin\/18.5.1027","volume":"18","author":"H van Gijssel","year":"1997","unstructured":"van Gijssel H (1997) p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion. Carcinogenesis 18(5):1027\u20131033. https:\/\/doi.org\/10.1093\/carcin\/18.5.1027","journal-title":"Carcinogenesis"},{"issue":"September","key":"1973_CR38","doi-asserted-by":"publisher","first-page":"102750","DOI":"10.1016\/j.micron.2019.102750","volume":"126","author":"H Xiao","year":"2019","unstructured":"Xiao H, Chen Y, Alnaggar M (2019) Silver nanoparticles induce cell death of colon cancer cells through impairing cytoskeleton and membrane nanostructure. Micron 126(September):102750. https:\/\/doi.org\/10.1016\/j.micron.2019.102750","journal-title":"Micron"},{"issue":"1","key":"1973_CR39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.cgh.2010.08.019","volume":"9","author":"JD Yang","year":"2011","unstructured":"Yang JD, Kim WR, Coelho R, Mettler TA, Benson JT, Sanderson SO, Therneau TM, Kim B, Roberts LR (2011) Cirrhosis is present in most patients with hepatitis B and hepatocellular carcinoma. Clin Gastroenterol Hepatol 9(1):64\u201370. https:\/\/doi.org\/10.1016\/j.cgh.2010.08.019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"June","key":"1973_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fchem.2020.00376","volume":"8","author":"SB Yaqoob","year":"2020","unstructured":"Yaqoob SB, Adnan R, Rameez Khan RM, Rashid M (2020) Gold, silver, and palladium nanoparticles: a chemical tool for biomedical applications. Front Chem 8(June):1\u201315. https:\/\/doi.org\/10.3389\/fchem.2020.00376","journal-title":"Front Chem"},{"key":"1973_CR41","doi-asserted-by":"publisher","first-page":"6487","DOI":"10.2147\/IJN.S135482","volume":"12","author":"Y-G Yuan","year":"2017","unstructured":"Yuan Y-G, Peng Q-L, Gurunathan S (2017) Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment. Int J Nanomedicine 12:6487\u20136502. https:\/\/doi.org\/10.2147\/IJN.S135482","journal-title":"Int J Nanomedicine"},{"key":"1973_CR42","first-page":"2018","volume-title":"Silver nanoparticles potentiates cytotoxicity and apoptotic potential of camptothecin in human cervical cancer cells","author":"Y Yuan","year":"2018","unstructured":"Yuan Y, Zhang S, Hwang J, Kong I (2018) Silver nanoparticles potentiates cytotoxicity and apoptotic potential of camptothecin in human cervical cancer cells, p 2018"},{"issue":"6","key":"1973_CR43","doi-asserted-by":"publisher","first-page":"e37782","DOI":"10.1371\/journal.pone.0037782","volume":"7","author":"S Zamorano","year":"2012","unstructured":"Zamorano S, Rojas-Rivera D, Lisbona F, Parra V, Court FA, Villegas R, Cheng EH, Korsmeyer SJ, Lavandero S, Hetz C (2012) A BAX\/BAK and cyclophilin D-independent intrinsic apoptosis pathway. PLoS One 7(6):e37782. https:\/\/doi.org\/10.1371\/journal.pone.0037782","journal-title":"PLoS One"},{"key":"1973_CR44","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.2147\/IJN.S198895","volume":"14","author":"H Zhang","year":"2019","unstructured":"Zhang H, Jacob JA, Jiang Z, Xu S, Sun K, Zhong Z, Varadharaju N, Shanmugam A (2019a) Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata. Int J Nanomedicine 14:3517\u20133524. https:\/\/doi.org\/10.2147\/IJN.S198895","journal-title":"Int J Nanomedicine"},{"key":"1973_CR45","doi-asserted-by":"publisher","unstructured":"Zhang LX, Lv Y, Xu AM, Wang HZ (2019b) The prognostic significance of serum gamma-glutamyltransferase levels and AST\/ALT in primary hepatic carcinoma. BMC Cancer 19(1). https:\/\/doi.org\/10.1186\/s12885-019-6011-8","DOI":"10.1186\/s12885-019-6011-8"},{"issue":"7","key":"1973_CR46","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.biopha.2013.04.003","volume":"67","author":"Q Zheng","year":"2013","unstructured":"Zheng Q, Yang H, Wei J, Tong J l, Shu Y q (2013) The role and mechanisms of nanoparticles to enhance radiosensitivity in hepatocellular cell. Biomed Pharmacother 67(7):569\u2013575. https:\/\/doi.org\/10.1016\/j.biopha.2013.04.003","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1973_CR47","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s11671-016-1419-4","volume":"11","author":"B Zhu","year":"2016","unstructured":"Zhu B, Li Y, Lin Z, Zhao M, Xu T, Wang C, Deng N (2016) Silver nanoparticles induce HePG-2 cells apoptosis through ROS-mediated signaling pathways. Nanoscale Res Lett 11(1):197\u2013198. https:\/\/doi.org\/10.1186\/s11671-016-1419-4","journal-title":"Nanoscale Res Lett"},{"issue":"4","key":"1973_CR48","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.18632\/oncotarget.22563","volume":"9","author":"E Zielinska","year":"2018","unstructured":"Zielinska E, Zauszkiewicz-Pawlak A, Wojcik M, Inkielewicz-Stepniak I (2018) Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma. Oncotarget 9(4):4675\u20134697. https:\/\/doi.org\/10.18632\/oncotarget.22563","journal-title":"Oncotarget"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01973-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-01973-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-01973-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:01:00Z","timestamp":1631923260000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-020-01973-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["1973"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-01973-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"assertion":[{"value":"18 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the studies were approved by the scientific research ethical committee at the Faculty of Pharmacy Helwan University, Cairo, Egypt (No. 17A2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}