{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:02:47Z","timestamp":1740106967612,"version":"3.37.3"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00210-020-02006-w","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T15:02:49Z","timestamp":1604156569000},"page":"697-705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide"],"prefix":"10.1007","volume":"394","author":[{"given":"D\u00e9bora Luiza","family":"Quintilhano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Romani","family":"Miksza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winny Beatriz","family":"de Souza Galia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahira Oliveira Ramalho Costa","family":"Ramalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Ferraz","family":"Lucena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00edra Mello Rezende","family":"Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda Rodrigues","family":"Graciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helenir Medri","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-937X","authenticated-orcid":false,"given":"Gisele Lopes","family":"Bertolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"2006_CR1","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","volume":"132","author":"LL Baggio","year":"2007","unstructured":"Baggio LL, Drucker DJ (2007) Biology of Incretins: GLP-1 and GIP. Gastroenterology 132:2131\u20132157. https:\/\/doi.org\/10.1053\/j.gastro.2007.03.054","journal-title":"Gastroenterology"},{"key":"2006_CR2","first-page":"257","volume":"39","author":"N Bennani-Baiti","year":"2009","unstructured":"Bennani-Baiti N, Walsh D (2009) What is cancer anorexia-cachexia syndrome? A historical perspective. J R Coll Physicians Edinb 39:257\u2013262","journal-title":"J R Coll Physicians Edinb"},{"key":"2006_CR3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/dom.12253","volume":"16","author":"GB Bolli","year":"2014","unstructured":"Bolli GB, Owens DR (2014) Lixisenatide, a novel GLP-1 receptor agonist: efficacy, safety and clinical implications for type 2 diabetes mellitus. Diabetes Obes Metab 16:588\u2013601. https:\/\/doi.org\/10.1111\/dom.12253","journal-title":"Diabetes Obes Metab"},{"key":"2006_CR4","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1677\/jme.0.0290347","volume":"29","author":"A Bulotta","year":"2002","unstructured":"Bulotta A, Hui H, Anastasi E, Bertolotto C, Boros LG, Di Mario U, Perfetti R (2002) Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. J Mol Endocrinol 29:347\u2013360. https:\/\/doi.org\/10.1677\/jme.0.0290347","journal-title":"J Mol Endocrinol"},{"key":"2006_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S1262-3636(08)73398-6","volume":"34","author":"J Buteau","year":"2008","unstructured":"Buteau J (2008) GLP-1 receptor signaling: effects on pancreatic beta-cell proliferation and survival. Diabetes Metab 34:73\u201377. https:\/\/doi.org\/10.1016\/S1262-3636(08)73398-6","journal-title":"Diabetes Metab"},{"key":"2006_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/cbf.2792","volume":"30","author":"P Cassolla","year":"2012","unstructured":"Cassolla P, Moreira CCL, Liboni TF, Zaia CTBV, Borba-Murad GR, Bazotte RB, Souza HM (2012) Changes in blood metabolic parameters during the development of Walker-256 tumour-induced cachexia in rats are not caused by decreased food intake. Cell Biochem Funct 30:265\u2013270. https:\/\/doi.org\/10.1002\/cbf.2792","journal-title":"Cell Biochem Funct"},{"key":"2006_CR7","first-page":"503","volume":"12","author":"M Christensen","year":"2009","unstructured":"Christensen M, Knop FK, Holst JJ, Vilsboll T (2009) Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus. IDrugs 12:503\u2013513","journal-title":"IDrugs"},{"key":"2006_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1055\/s-2007-1004919","volume":"22","author":"R Curi","year":"1990","unstructured":"Curi R, Rocha MS, Vecchia MG, Carpinelli AR (1990) Inhibition of insulin secretion by rat mesenteric lymphocytes in incubated pancreatic islet cells. Horm Metab Res 22:356\u2013357. https:\/\/doi.org\/10.1055\/s-2007-1004919","journal-title":"Horm Metab Res"},{"key":"2006_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000477117","volume":"42","author":"CC Da Silva Franco","year":"2017","unstructured":"Da Silva Franco CC, Previate C, De Barros Machado KG, Piovan S, Miranda RA, Prates KV, Moreira VM, De Oliveira JC, Barella LF, Gomes RM, Francisco FA, Martins IP, Pavanello A, Ribeiro TA, T\u00f3folo LP, Malta A, De Souza AA, Alves VS, Da Silva Silveira S, Mar\u00e7al Natali MR, Fernando Besson JC, De Morais H, De Souza HM, De Sant Anna JR, Alves De Castro Prado MA, De Freitas Mathias PC (2017) Chronic glibenclamide treatment attenuates Walker-256 tumour growth in prediabetic obese rats. Cell Physiol Biochem 42:81\u201390. https:\/\/doi.org\/10.1159\/000477117","journal-title":"Cell Physiol Biochem"},{"key":"2006_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.lfs.2016.12.016","volume":"171","author":"F De Fatima Silva","year":"2017","unstructured":"De Fatima Silva F, Ortiz-Silva M, Souza WBG, Cassolla P, Graciano MFR, Zaia CTBV, Zaia D, Carpinelli AR, Da Silva FG, Souza HM (2017) Pioglitazone improves insulin sensitivity and reduces weight loss in Walker-256 tumor-bearing rats. Life Sci 171:68\u201374. https:\/\/doi.org\/10.1016\/j.lfs.2016.12.016","journal-title":"Life Sci"},{"key":"2006_CR11","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1139\/cjpp-2017-0171","volume":"96","author":"F De Fatima Silva","year":"2018","unstructured":"De Fatima Silva F, Ortiz-Silva M, Souza WBG, Cassolla P, Da Silva FG, Graciano MFR, Carpinelli AR, Souza HM (2018) Effects of metformin on insulin resistance and metabolic disorders in tumor-bearing rats with advanced cachexia. Can J Physiol Pharmacol 96:498\u2013505. https:\/\/doi.org\/10.1139\/cjpp-2017-0171","journal-title":"Can J Physiol Pharmacol"},{"key":"2006_CR12","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/MCO.0b013e328042ba90","volume":"10","author":"J Delarue","year":"2007","unstructured":"Delarue J, Magnan C (2007) Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care 10:142\u2013148. https:\/\/doi.org\/10.1097\/MCO.0b013e328042ba90","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2006_CR13","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1073\/pnas.84.10.3434","volume":"84","author":"DJ Drucker","year":"1987","unstructured":"Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF (1987) Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A 84:3434\u20133438. https:\/\/doi.org\/10.1073\/pnas.84.10.3434","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2006_CR14","doi-asserted-by":"publisher","first-page":"5149","DOI":"10.1210\/en.2003-0323","volume":"144","author":"L Farilla","year":"2003","unstructured":"Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R (2003) Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 144:5149\u20135158. https:\/\/doi.org\/10.1210\/en.2003-0323","journal-title":"Endocrinology"},{"key":"2006_CR15","doi-asserted-by":"publisher","first-page":"E1033","DOI":"10.1152\/ajpendo.1990.258.6.E1033","volume":"258","author":"LC Fernandes","year":"1990","unstructured":"Fernandes LC, Machado UF, Nogueira CR, Carpinelli AR, Curi R (1990) Insulin secretion in Walker 256 tumor cachexia. Am J Physiol Endocrinol Metab 258:E1033\u2013E1036. https:\/\/doi.org\/10.1152\/ajpendo.1990.258.6.E1033","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2006_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/cbf.679","volume":"14","author":"LC Fernandes","year":"1996","unstructured":"Fernandes LC, Mattozo CA, Machado UF, Rosa LF, Curi R (1996) Insulin treatment can abolish changes in glucose and glutamine metabolism of lymphocytes and macrophages caused by the implantation of the Walker 256 tumour. Cell Biochem Funct 14:187\u2013192. https:\/\/doi.org\/10.1002\/cbf.679","journal-title":"Cell Biochem Funct"},{"key":"2006_CR17","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1463-1326.2012.01560.x","volume":"14","author":"MS Fineman","year":"2012","unstructured":"Fineman MS, Cirincione BB, Maggs D, Diamant M (2012) GLP-1 based therapies: differential effects on fasting and postprandial glucose. Diabetes Obes Metab 14:675\u2013688. https:\/\/doi.org\/10.1111\/j.1463-1326.2012.01560.x","journal-title":"Diabetes Obes Metab"},{"key":"2006_CR18","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1517\/14656566.2013.838559","volume":"14","author":"T Forst","year":"2013","unstructured":"Forst T, Pf\u00fctzner A (2013) Pharmacological profile, efficacy and safety of lixisenatide in type 2 diabetes mellitus. Expert Opin Pharmacother 14:2281\u20132296. https:\/\/doi.org\/10.1517\/14656566.2013.838559","journal-title":"Expert Opin Pharmacother"},{"key":"2006_CR19","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/qjmed\/hci127","volume":"98","author":"JN Gordon","year":"2005","unstructured":"Gordon JN, Grenn SR, Goggin PM (2005) Cancer cachexia. Q J Med 98:779\u2013788. https:\/\/doi.org\/10.1093\/qjmed\/hci127","journal-title":"Q J Med"},{"key":"2006_CR20","first-page":"400","volume":"49","author":"G Haschke","year":"2006","unstructured":"Haschke G, Haag-Diergarten S, Werner U, Kramer W, Herling AW (2006) The GLP-1 receptor agonist AVE0010 preserves beta cell function and insulin secretion after a 6 week treatment in male obese Zucker diabetic fatty rats - an isolated perfused pancreas study. Diabetologia 49:400\u2013401","journal-title":"Diabetologia"},{"key":"2006_CR21","doi-asserted-by":"publisher","first-page":"T31","DOI":"10.1530\/JOE-13-0221","volume":"221","author":"C Holscher","year":"2014","unstructured":"Holscher C (2014) Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. J Endocrinol 221:T31\u2013T41. https:\/\/doi.org\/10.1530\/JOE-13-0221","journal-title":"J Endocrinol"},{"key":"2006_CR22","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","volume":"87","author":"JJ Holst","year":"2007","unstructured":"Holst JJ (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87:1409\u20131439. https:\/\/doi.org\/10.1152\/physrev.00034.2006","journal-title":"Physiol Rev"},{"key":"2006_CR23","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/361362a0","volume":"361","author":"GG Holz IV","year":"1993","unstructured":"Holz GG IV, K\u00fchtreiber WM, Habener JF (1993) Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 361:362\u2013365. https:\/\/doi.org\/10.1038\/361362a0","journal-title":"Nature"},{"key":"2006_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s12672-013-0163-9","volume":"5","author":"MA Honors","year":"2014","unstructured":"Honors MA, Kinzig KP (2014) Chronic Exendin-4 treatment prevents the development of cancer cachexia symptoms in male rats bearing the Yoshida sarcoma. Horm Cancer 5:33\u201341. https:\/\/doi.org\/10.1007\/s12672-013-0163-9","journal-title":"Horm Cancer"},{"key":"2006_CR25","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.ejim.2014.03.005","volume":"25","author":"A Lund","year":"2014","unstructured":"Lund A, Knop FK, Vilsb\u00f8ll T (2014) Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities. Eur J Inter Med 25:407\u2013414. https:\/\/doi.org\/10.1016\/j.ejim.2014.03.005","journal-title":"Eur J Inter Med"},{"key":"2006_CR26","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1007\/s001090000137","volume":"78","author":"G Mantovani","year":"2000","unstructured":"Mantovani G, Macci\u00f2 A, Mura L, Massa E, Mudu MC, Mulas C, Lusso MR, Madeddu C, Dess\u00ec A (2000) Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites. J Mol Med 78:554\u2013561. https:\/\/doi.org\/10.1007\/s001090000137","journal-title":"J Mol Med"},{"key":"2006_CR27","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.freeradbiomed.2007.10.047","volume":"44","author":"R Mastrocola","year":"2008","unstructured":"Mastrocola R, Reffo P, Penna F, Tomasinelli CE, Boccuzzi G, Baccino FM, Aragno M, Costelli P (2008) Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress. Free Radic Biol Med 44:584\u2013593. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.10.047","journal-title":"Free Radic Biol Med"},{"key":"2006_CR28","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/nrendo.2012.140","volume":"8","author":"JJ Meier","year":"2012","unstructured":"Meier JJ (2012) GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 8:728\u2013742. https:\/\/doi.org\/10.1038\/nrendo.2012.140","journal-title":"Nat Rev Endocrinol"},{"key":"2006_CR29","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1210\/endo.140.3.6550","volume":"140","author":"C Montrose-Rafizadeh","year":"1999","unstructured":"Montrose-Rafizadeh C, Avdonin P, Garant MJ, Rodgers BD, Kole S, Yang H, Levine MA, Schwindinger W, Bernier M (1999) Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. Endocrinology 140:1132\u20131140. https:\/\/doi.org\/10.1210\/endo.140.3.6550","journal-title":"Endocrinology"},{"key":"2006_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/B978-0-12-800101-1.00002-8","volume":"121","author":"P Nadkarni","year":"2014","unstructured":"Nadkarni P, Chepurny OG, Holz GG (2014) Regulation of glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci 121:23\u201365. https:\/\/doi.org\/10.1016\/B978-0-12-800101-1.00002-8","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2006_CR31","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1152\/ajpcell.1996.271.3.C804","volume":"271","author":"SR Neto","year":"1996","unstructured":"Neto SR, Zorn TM, Curi R, Carpinelli AR (1996) Impairment of insulin secretion in pancreatic islets isolated from Walker-256 tumor-bearing rats. Am J Phys Cell Phys 271:804\u2013809. https:\/\/doi.org\/10.1152\/ajpcell.1996.271.3.C804","journal-title":"Am J Phys Cell Phys"},{"key":"2006_CR32","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2147\/DMSO.S45379","volume":"6","author":"AB Petersen","year":"2013","unstructured":"Petersen AB, Christensen M (2013) Clinical potential of lixisenatide once daily treatment for type 2 diabetes mellitus. Diabetes Metab Syndr Obes 6:217\u2013231. https:\/\/doi.org\/10.2147\/DMSO.S45379","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2006_CR33","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jdiacomp.2014.01.012","volume":"28","author":"J Rosenstock","year":"2014","unstructured":"Rosenstock J, Hanefeld M, Shamanna P, Min KW, Boka G, Miossec P, Zhou T, Muehlen-Bartmer I, Ratner RE (2014) Beneficial effects of once-daily lixisenatide on overall and postprandial glycemic levels without significant excess of hypoglycemia in type 2 diabetes inadequately controlled on a sulfonylurea with or without metformin (GetGoal-S). J Diabetes Complicat 28:386\u2013392. https:\/\/doi.org\/10.1016\/j.jdiacomp.2014.01.012","journal-title":"J Diabetes Complicat"},{"key":"2006_CR34","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00109-017-1508-6","volume":"95","author":"M Shigeto","year":"2017","unstructured":"Shigeto M, Cha CY, Rorsman P, Kaku K (2017) A role of PLC\/PKC-dependent pathway in GLP-1-stimulated insulin secretion. J Mol Med 95:361\u2013368. https:\/\/doi.org\/10.1007\/s00109-017-1508-6","journal-title":"J Mol Med"},{"key":"2006_CR35","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.2337\/db10-0689","volume":"59","author":"KW Sloop","year":"2010","unstructured":"Sloop KW, Willard FS, Brenner MB, Ficorilli J, Valasek K, Showalter AD, Farb TB, Cao JX, Cox AL, Michael MD, Gutierrez Sanfeliciano SM, Tebbe MJ, Coghlan MJ (2010) Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes 59:3099\u20133107. https:\/\/doi.org\/10.2337\/db10-0689","journal-title":"Diabetes"},{"key":"2006_CR36","doi-asserted-by":"publisher","first-page":"741","DOI":"10.2337\/diabetes.49.5.741","volume":"49","author":"DA Stoffers","year":"2000","unstructured":"Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM (2000) Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741\u2013748. https:\/\/doi.org\/10.2337\/diabetes.49.5.741","journal-title":"Diabetes"},{"key":"2006_CR37","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/0003-9861(87)90405-x","volume":"255","author":"L Tessitore","year":"1987","unstructured":"Tessitore L, Bonelli G, Cecchini G, Amenta JS, Baccino FM (1987) Regulation of protein turnover versus growth state: ascites hepatoma as a model for studies both in the animal and in vitro. Arch Biochem Biophys 255:372\u2013384. https:\/\/doi.org\/10.1016\/0003-9861(87)90405-x","journal-title":"Arch Biochem Biophys"},{"key":"2006_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/bjc.1993.4","volume":"67","author":"L Tessitore","year":"1993","unstructured":"Tessitore L, Costelli P, Baccino FM (1993) Humoral mediation for cachexia in tumour-bearing rats. Br J Cancer 67:15\u201323. https:\/\/doi.org\/10.1038\/bjc.1993.4","journal-title":"Br J Cancer"},{"key":"2006_CR39","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1055\/s-2008-1042426","volume":"40","author":"D Tews","year":"2008","unstructured":"Tews D, Werner U, Eckel J (2008) Enhanced protection against cytokine- and fatty acid induced apoptosis in pancreatic beta cells by combined treatment with glucagon like peptide-1 receptor agonists and insulin analogues. Horm Metab Res 40:172\u2013180. https:\/\/doi.org\/10.1055\/s-2008-1042426","journal-title":"Horm Metab Res"},{"key":"2006_CR40","doi-asserted-by":"publisher","first-page":"8641","DOI":"10.1073\/pnas.89.18.8641","volume":"89","author":"B Thorens","year":"1992","unstructured":"Thorens B (1992) Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci U S A 89:8641\u20138645. https:\/\/doi.org\/10.1073\/pnas.89.18.8641","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2006_CR41","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1124\/jpet.103.051987","volume":"307","author":"C Thorkildsen","year":"2003","unstructured":"Thorkildsen C, Neve S, Larsen BD, Meier E, Petersen JS (2003) Glucagon-like peptide 1 receptor agonist ZP10A increases insulin mRNA expression and prevents diabetic progression in db\/db mice. J Pharmacol Exp Ther 307:490\u2013496. https:\/\/doi.org\/10.1124\/jpet.103.051987","journal-title":"J Pharmacol Exp Ther"},{"key":"2006_CR42","doi-asserted-by":"publisher","first-page":"243S","DOI":"10.1093\/jn\/129.1.243S","volume":"129","author":"MJ Tisdale","year":"1999","unstructured":"Tisdale MJ (1999) Wasting in cancer. J Nutr 129:243S\u2013246S. https:\/\/doi.org\/10.1093\/jn\/129.1.243S","journal-title":"J Nutr"},{"key":"2006_CR43","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1152\/physiol.00019.2005","volume":"20","author":"MJ Tisdale","year":"2005","unstructured":"Tisdale MJ (2005) Molecular pathways leading to cancer cachexia. Physiology 20:340\u2013348. https:\/\/doi.org\/10.1152\/physiol.00019.2005","journal-title":"Physiology"},{"key":"2006_CR44","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jdiacomp.2013.06.003","volume":"28","author":"U Werner","year":"2014","unstructured":"Werner U (2014) Effects of the GLP-1 receptor agonist lixisenatide on postprandial glucose and gastric emptying \u2013 preclinical evidence. J Diabetes Complicat 28:110\u2013114. https:\/\/doi.org\/10.1016\/j.jdiacomp.2013.06.003","journal-title":"J Diabetes Complicat"},{"key":"2006_CR45","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2337\/db07-1581","volume":"57","author":"U Werner","year":"2008","unstructured":"Werner U, Vandewalle B, Kerr Conte J, Pattou F, Pruniaux M, Herling AW (2008) The GLP-1 receptor agonist AVE0010 improves GSIS, prevents lipotoxicity-induced insulin depletion and preserves \u03b2-cell function in human pancreatic islets. Diabetes 57:3\u20134","journal-title":"Diabetes"},{"key":"2006_CR46","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.regpep.2010.05.008","volume":"164","author":"U Werner","year":"2010","unstructured":"Werner U, Haschke G, Herling AW, Kramer W (2010) Pharmacological profile of lixisenatide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Regul Pept 164:58\u201364. https:\/\/doi.org\/10.1016\/j.regpep.2010.05.008","journal-title":"Regul Pept"},{"key":"2006_CR47","first-page":"19","volume":"26","author":"G Wilcox","year":"2005","unstructured":"Wilcox G (2005) Insulin and insulin resistance. Clin Biochem Rev 26:19\u201339","journal-title":"Clin Biochem Rev"},{"key":"2006_CR48","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.2337\/diabetes.48.12.2270","volume":"48","author":"G Xu","year":"1999","unstructured":"Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270\u20132276. https:\/\/doi.org\/10.2337\/diabetes.48.12.2270","journal-title":"Diabetes"},{"key":"2006_CR49","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1172\/JCI104130","volume":"39","author":"RS Yalow","year":"1960","unstructured":"Yalow RS, Berson SA (1960) Immunoassay of endogenous plasma insulin in man. J Clin Invest 39:1157\u20131175. https:\/\/doi.org\/10.1172\/JCI104130","journal-title":"J Clin Invest"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-02006-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00210-020-02006-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-02006-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T10:05:54Z","timestamp":1617012354000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00210-020-02006-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,31]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["2006"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-02006-w","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"type":"print","value":"0028-1298"},{"type":"electronic","value":"1432-1912"}],"subject":[],"published":{"date-parts":[[2020,10,31]]},"assertion":[{"value":"23 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocols were approved by the Ethics Committee for Animal Use of the State University of Londrina (CEUA\/UEL, register number 09600).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}