{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:40:46Z","timestamp":1761946846777,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["20K16136","19K16505"],"award-info":[{"award-number":["20K16136","19K16505"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National University Heart Centre Singapore (NUHCS) Cardiovascular Research Institute","award":["NUHSRO\/2019\/082\/Core"],"award-info":[{"award-number":["NUHSRO\/2019\/082\/Core"]}]},{"name":"SCEPTRE CG Seed Grant","award":["NMRC\/CG\/M008\/2017"],"award-info":[{"award-number":["NMRC\/CG\/M008\/2017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00210-020-02047-1","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T19:26:26Z","timestamp":1610393186000},"page":"1103-1112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation"],"prefix":"10.1007","volume":"394","author":[{"given":"Ryuichi","family":"Kambayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Nunoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Hagiwara-Nagasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Izumi-Nakaseko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopalakrishnan","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric Chun Yong","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"2047_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00210-011-0599-9","volume":"383","author":"R Bogdan","year":"2011","unstructured":"Bogdan R, Goegelein H, Ruetten H (2011) Effect of dronedarone on Na+, Ca2+ and HCN channels. Naunyn Schmiedebergs Arch Pharmacol 383:347\u2013356","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2047_CR2","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0008-6363(98)00021-2","volume":"38","author":"RF Bosch","year":"1998","unstructured":"Bosch RF, Gaspo R, Busch AE, Lang HJ, Li GR, Nattel S (1998) Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 38:441\u2013450","journal-title":"Cardiovasc Res"},{"key":"2047_CR3","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1111\/j.1476-5381.1995.tb16397.x","volume":"116","author":"P Chatelain","year":"1995","unstructured":"Chatelain P, Meysmans L, Matt\u00e9azzi JR, Beaufort P, Clinet M (1995) Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the beta-adrenoceptor and adenylate cyclase in rat heart. Br J Pharmacol 116:1949\u20131956","journal-title":"Br J Pharmacol"},{"key":"2047_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/00005344-200302000-00007","volume":"41","author":"P Gautier","year":"2003","unstructured":"Gautier P, Guillemare E, Marion A, Bertrand JP, Tourneur Y, Nisato D (2003) Electrophysiologic characterization of dronedarone in guinea pig ventricular cells. J Cardiovasc Pharmacol 41:191\u2013202","journal-title":"J Cardiovasc Pharmacol"},{"key":"2047_CR5","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1097\/00005344-200012000-00017","volume":"36","author":"E Guillemare","year":"2000","unstructured":"Guillemare E, Marion A, Nisato D, Gautier P (2000) Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cells. J Cardiovasc Pharmacol 36:802\u2013805","journal-title":"J Cardiovasc Pharmacol"},{"key":"2047_CR6","doi-asserted-by":"publisher","unstructured":"Hagiwara-Nagasawa M, Kambayashi R, Goto A, Nunoi Y, Izumi-Nakaseko H, Chiba K, Wada T, Takei Y, Matsumoto A, Sugiyama A (2020) Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-020-01997-w","DOI":"10.1007\/s00210-020-01997-w"},{"key":"2047_CR7","first-page":"228","volume-title":"Basic & Clinical Pharmacology","author":"RD Harvey","year":"2018","unstructured":"Harvey RD, Grant AO (2018) Agents used in cardiac arrhythmias. In: Katzung BG (ed) Basic & Clinical Pharmacology, 14th edn. McGraw Hill Education, New York, pp 228\u2013253","edition":"14"},{"key":"2047_CR8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1056\/NEJMoa0803778","volume":"360","author":"SH Hohnloser","year":"2009","unstructured":"Hohnloser SH, Crijns HJ, van Eickels M, Gaudin C, Page RL, Torp-Pedersen C, Connolly SJ, ATHENA Investigators (2009) Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med 360:668\u2013678","journal-title":"N Engl J Med"},{"key":"2047_CR9","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1254\/jphs.09061SC","volume":"110","author":"H Iwasaki","year":"2009","unstructured":"Iwasaki H, Takahara A, Nakamura Y, Satoh Y, Nagai T, Shinkai N, Sugiyama A (2009) Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropahrmacological effects on atria of chronic atrioventricular block dogs. J Pharmacol Sci 110:410\u2013414","journal-title":"J Pharmacol Sci"},{"key":"2047_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1161\/01.RES.72.1.75","volume":"72","author":"NK Jurkiewicz","year":"1993","unstructured":"Jurkiewicz NK, Sanguinetti MC (1993) Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circ Res 72:75\u201383","journal-title":"Circ Res"},{"key":"2047_CR11","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1007\/s00380-020-01612-1","volume":"35","author":"R Kambayashi","year":"2020","unstructured":"Kambayashi R, Hagiwara-Nagasawa M, Ichikawa T, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Matsumoto A, Takahara A, Sugiyama A (2020a) Analysis of electropharmacological effects of AVE0118 on the atria of chronic atrioventricular block dogs: characterization of anti-atrial fibrillatory action by atrial repolarization-delaying agent. Heart Vessels 35:1316\u20131322","journal-title":"Heart Vessels"},{"key":"2047_CR12","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12012-019-09559-0","volume":"20","author":"R Kambayashi","year":"2020","unstructured":"Kambayashi R, Hagiwara-Nagasawa M, Kondo Y, Yeo ZJ, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Leow JWH, Venkatesan G, Matsumoto A, Chan ECY, Sugiyama A (2020b) How the deuteration of dronedarone can modify its cardiovascular profile: in vivo characterization of electropharmacological effects of poyendarone, a deuterated analogue of dronedarone. Cardiovasc Toxicol 20:339\u2013350","journal-title":"Cardiovasc Toxicol"},{"key":"2047_CR13","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","volume":"160","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG (2010) Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160:1577\u20131579","journal-title":"Br J Pharmacol"},{"key":"2047_CR14","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1056\/NEJMoa0800456","volume":"358","author":"L K\u00f8ber","year":"2008","unstructured":"K\u00f8ber L, Torp-Pedersen C, McMurray JJ, G\u00f8tzsche O, L\u00e9vy S, Crijns H, Amlie J, Carlsen J (2008) Increased mortality after dronedarone therapy for severe heart failure. N Engl J Med 358:2678\u20132687","journal-title":"N Engl J Med"},{"key":"2047_CR15","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","volume":"160","author":"J McGrath","year":"2010","unstructured":"McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C (2010) Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160:1573\u20131576","journal-title":"Br J Pharmacol"},{"key":"2047_CR16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s12012-017-9434-y","volume":"18","author":"Y Motokawa","year":"2018","unstructured":"Motokawa Y, Nakamura Y, Hagiwara-Nagasawa M, Goto A, Chiba K, Lubna NJ, Izumi-Nakaseko H, Ando K, Naito AT, Yamazaki H, Sugiyama A (2018) In vivo analysis of the anti-atrial fibrillatory, proarrhythmic and cardiodepressive profile of dronedarone as a guide for safety pharmacological evaluation of antiarrhythmic drugs. Cardiovasc Toxicol 18:242\u2013251","journal-title":"Cardiovasc Toxicol"},{"key":"2047_CR17","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1161\/CIRCULATIONAHA.109.858027","volume":"120","author":"C Patel","year":"2009","unstructured":"Patel C, Yan GX, Kowey PR (2009) Dronedarone. Circulation 120:636\u2013644","journal-title":"Circulation"},{"key":"2047_CR18","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","volume":"114","author":"MJ Shen","year":"2014","unstructured":"Shen MJ, Zipes DP (2014) Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res 114:1004\u20131021","journal-title":"Circ Res"},{"key":"2047_CR19","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/bjp.2008.240","volume":"154","author":"A Sugiyama","year":"2008","unstructured":"Sugiyama A (2008) Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. Br J Pharmacol 154:1528\u20131537","journal-title":"Br J Pharmacol"},{"key":"2047_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1254\/jjp.87.74","volume":"87","author":"A Sugiyama","year":"2001","unstructured":"Sugiyama A, Satoh Y, Hashimoto K (2001) Acute electropharmacological effects of intravenously administered amiodarone assessed in the in vivo canine model. Jpn J Pharmacol 87:74\u201382","journal-title":"Jpn J Pharmacol"},{"key":"2047_CR21","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1254\/jjp.88.341","volume":"88","author":"A Sugiyama","year":"2002","unstructured":"Sugiyama A, Ishida Y, Satoh Y, Aoki S, Hori M, Akie Y, Kobayashi Y, Hashimoto K (2002) Electrophysiological, anatomical and histological remodeling of the heart to AV block enhances susceptibility to arrhythmogenic effects of QT-prolonging drugs. Jpn J Pharmacol 88:341\u2013350","journal-title":"Jpn J Pharmacol"},{"key":"2047_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1254\/jphs.FP0060945","volume":"103","author":"K Wang","year":"2007","unstructured":"Wang K, Takahara A, Nakamura Y, Aonuma K, Matsumoto M, Sugiyama A (2007) In vivo electropharmacological effects of amiodarone and candesartan on atria of chronic atrioventricular block dogs. J Pharmacol Sci 103:207\u2013213","journal-title":"J Pharmacol Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-02047-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-020-02047-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-020-02047-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T09:08:05Z","timestamp":1623834485000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-020-02047-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2047"],"URL":"https:\/\/doi.org\/10.1007\/s00210-020-02047-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"type":"print","value":"0028-1298"},{"type":"electronic","value":"1432-1912"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"26 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experiments were approved by the Toho University Animal Care and User Committee (No. 19-52-396) and performed according to the Guideline for the Care and Use of Laboratory Animals of Toho University and ARRIVE guidelines (McGrath et al. ; Kilkenny et al. ).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}