{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:40:01Z","timestamp":1763480401652,"version":"3.37.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Vali-e-Asr Reproductive Health Research Center of Tehran University of Medical Sciences, Iran.","award":["94-03-39-30352"],"award-info":[{"award-number":["94-03-39-30352"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00210-021-02071-9","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T16:03:01Z","timestamp":1615219381000},"page":"1487-1495","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of oral melatonin supplementation on MT-ATP6 gene expression and IVF outcomes in Iranian infertile couples: a nonrandomized controlled trial"],"prefix":"10.1007","volume":"394","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-0290","authenticated-orcid":false,"given":"Fatemeh Sadat","family":"Hosseini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Shamsipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Yazdekhasti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firoozeh","family":"Akbari-Asbagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Shahraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hamid","family":"Aghaee-Bakhtiari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"2071_CR1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S1472-6483(10)61174-1","volume":"11","author":"A Agarwal","year":"2005","unstructured":"Agarwal A, Gupta S, Sharma R (2005a) Oxidative stress and its implications in female infertility - a clinician's perspective. Reprod BioMed Online 11:641\u2013650","journal-title":"Reprod BioMed Online"},{"key":"2071_CR2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1477-7827-3-28","volume":"3","author":"A Agarwal","year":"2005","unstructured":"Agarwal A, Gupta S, Sharma RK (2005b) Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 3:28","journal-title":"Reprod Biol Endocrinol"},{"key":"2071_CR3","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.1007\/s13277-015-3057-3","volume":"36","author":"SH Aghaee-Bakhtiari","year":"2015","unstructured":"Aghaee-Bakhtiari SH, Arefian E, Naderi M, Noorbakhsh F, Nodouzi V, Asgari M, Fard-Esfahani P, Mahdian R, Soleimani M (2015) MAPK and JAK\/STAT pathways targeted by miR-23a and miR-23b in prostate cancer: computational and in vitro approaches. Tumour Biol 36:4203\u20134212","journal-title":"Tumour Biol"},{"key":"2071_CR4","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/mrd.22871","volume":"84","author":"RJ Aitken","year":"2017","unstructured":"Aitken RJ (2017) Reactive oxygen species as mediators of sperm capacitation and pathological damage. Mol Reprod Dev 84:1039\u20131052","journal-title":"Mol Reprod Dev"},{"key":"2071_CR5","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.2164\/jandrol.112.016535","volume":"33","author":"RJ Aitken","year":"2012","unstructured":"Aitken RJ, Jones KT, Robertson SA (2012) Reactive oxygen species and sperm function--in sickness and in health. J Androl 33:1096\u20131106","journal-title":"J Androl"},{"issue":"1","key":"2071_CR6","first-page":"5","volume":"4","author":"T Baczkowski","year":"2004","unstructured":"Baczkowski T, Kurzawa R, Glabowski W (2004) Methods of embryo scoring in in vitro fertilization. Reprod Biol 4(1):5\u201322","journal-title":"Reprod Biol"},{"key":"2071_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/09513590.2011.589925","volume":"28","author":"AS Batioglu","year":"2012","unstructured":"Batioglu AS, Sahin U, Gurlek B, Ozturk N, Unsal E (2012) The efficacy of melatonin administration on oocyte quality. Gynecol Endocrinol 28:91\u201393","journal-title":"Gynecol Endocrinol"},{"key":"2071_CR8","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1210\/jcem-64-4-865","volume":"64","author":"A Brzezinski","year":"1987","unstructured":"Brzezinski A, Seibel MM, Lynch HJ, Deng M-H, Wurtman RJ (1987) Melatonin in human preovulatory follicular fluid. The Journal of Clinical Endocrinology & Metabolism 64:865\u2013867","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"2071_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00404-013-2801-4","volume":"288","author":"SJ Chen","year":"2013","unstructured":"Chen SJ, Allam JP, Duan YG, Haidl G (2013) Influence of reactive oxygen species on human sperm functions and fertilizing capacity including therapeutical approaches. Arch Gynecol Obstet 288:191\u2013199","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"2071_CR10","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/mrd.21295","volume":"78","author":"M El-Raey","year":"2011","unstructured":"El-Raey M, Geshi M, Somfai T, Kaneda M, Hirako M, Abdel-Ghaffar AE, Sosa GA, El-Roos ME, Nagai T (2011) Evidence of melatonin synthesis in the cumulus oocyte complexes and its role in enhancing oocyte maturation in vitro in cattle. Mol Reprod Dev 78(4):250\u2013262","journal-title":"Mol Reprod Dev"},{"issue":"9","key":"2071_CR11","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s10815-011-9604-y","volume":"28","author":"OG Eryilmaz","year":"2011","unstructured":"Eryilmaz OG, Devran A, Sarikaya E, Aksakal FN, Mollamahmutoglu L, Cicek N (2011) Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J Assist Reprod Genet 28(9):815\u2013820","journal-title":"J Assist Reprod Genet"},{"key":"2071_CR12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13048-014-0098-y","volume":"7","author":"S Fernando","year":"2014","unstructured":"Fernando S, Rombauts L (2014) Melatonin: shedding light on infertility?--a review of the recent literature. J Ovarian Res 7:98","journal-title":"J Ovarian Res"},{"key":"2071_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1385\/ENDO:27:2:119","volume":"27","author":"R Hardeland","year":"2005","unstructured":"Hardeland R (2005) Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 27:119\u2013130","journal-title":"Endocrine"},{"key":"2071_CR14","doi-asserted-by":"crossref","unstructured":"He C, Wang J, Zhang Z, Yang M, Li Y, Tian X, Ma T, Tao J, Zhu K, Song Y, Ji P, Liu G (2016) Mitochondria synthesize melatonin to ameliorate its function and improve mice oocyte's quality under in vitro conditions. Int J Mol Sci 17","DOI":"10.3390\/ijms17060939"},{"issue":"Suppl 1","key":"2071_CR15","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.fertnstert.2003.11.013","volume":"81","author":"RH Hsieh","year":"2004","unstructured":"Hsieh RH, Au HK, Yeh TS, Chang SJ, Cheng YF, Tzeng CR (2004) Decreased expression of mitochondrial genes in human unfertilized oocytes and arrested embryos. Fertil Steril 81(Suppl 1):912\u2013918","journal-title":"Fertil Steril"},{"key":"2071_CR16","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1093\/molehr\/5.5.402","volume":"5","author":"MT Itoh","year":"1999","unstructured":"Itoh MT, Ishizuka B, Kuribayashi Y, Amemiya A, Sumi Y (1999) Melatonin, its precursors, and synthesizing enzyme activities in the human ovary. Mol Hum Reprod 5:402\u2013408","journal-title":"Mol Hum Reprod"},{"key":"2071_CR17","first-page":"12","volume":"56","author":"EB Johnston-MacAnanny","year":"2011","unstructured":"Johnston-MacAnanny EB, DiLuigi AJ, Engmann LL, Maier DB, Benadiva CA, Nulsen JC (2011) Selection of first in vitro fertilization cycle stimulation protocol for good prognosis patients: gonadotropin releasing hormone antagonist versus agonist protocols. J Reprod Med 56:12\u201316","journal-title":"J Reprod Med"},{"key":"2071_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1477-7827-8-21","volume":"8","author":"RM Kamel","year":"2010","unstructured":"Kamel RM (2010) Management of the infertile couple: an evidence-based protocol. Reprod Biol Endocrinol 8:21","journal-title":"Reprod Biol Endocrinol"},{"key":"2071_CR19","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1210\/jc.2007-2616","volume":"93","author":"AJ Koppers","year":"2008","unstructured":"Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ (2008) Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. J Clin Endocrinol Metab 93:3199\u20133207","journal-title":"J Clin Endocrinol Metab"},{"key":"2071_CR20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0891-5849(98)00216-0","volume":"26","author":"AJ Kowaltowski","year":"1999","unstructured":"Kowaltowski AJ, Vercesi AE (1999) Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med 26:463\u2013471","journal-title":"Free Radic Biol Med"},{"key":"2071_CR21","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/S0015-0282(00)00486-6","volume":"73","author":"SH Lee","year":"2000","unstructured":"Lee SH, Han JH, Cho SW, Cha KE, Park SE, Cha KY (2000) Mitochondrial ATPase 6 gene expression in unfertilized oocytes and cleavage-stage embryos. Fertil Steril 73:1001\u20131005","journal-title":"Fertil Steril"},{"key":"2071_CR22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1016-8478(23)13725-3","volume":"15","author":"SH Lee","year":"2003","unstructured":"Lee SH, Lee S, Jun HS, Jeong HJ, Cha WT, Cho YS, Kim JH, Ku SY, Cha KY (2003) Expression of the mitochondrial ATPase6 gene and Tfam in Down syndrome. Mol Cell 15:181\u2013185","journal-title":"Mol Cell"},{"key":"2071_CR23","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.lfs.2004.03.003","volume":"75","author":"J Leon","year":"2004","unstructured":"Leon J, Acuna-Castroviejo D, Sainz RM, Mayo JC, Tan DX, Reiter RJ (2004) Melatonin and mitochondrial function. Life Sci 75:765\u2013790","journal-title":"Life Sci"},{"key":"2071_CR24","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/bja\/aes577","volume":"110","author":"DA Lowes","year":"2013","unstructured":"Lowes DA, Webster NR, Murphy MP, Galley HF (2013) Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. Br J Anaesth 110:472\u2013480","journal-title":"Br J Anaesth"},{"key":"2071_CR25","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1007\/PL00012498","volume":"59","author":"JC Mayo","year":"2002","unstructured":"Mayo JC, Sainz RM, Antoli I, Herrera F, Martin V, Rodriguez C (2002) Melatonin regulation of antioxidant enzyme gene expression. Cell Mol Life Sci 59:1706\u20131713","journal-title":"Cell Mol Life Sci"},{"key":"2071_CR26","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S1701-2163(16)32246-0","volume":"28","author":"JK Min","year":"2006","unstructured":"Min JK, Claman P, Hughes E (2006) Guidelines for the number of embryos to transfer following in vitro fertilization. J Obstet Gynaecol Can 28:799\u2013813","journal-title":"J Obstet Gynaecol Can"},{"key":"2071_CR27","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3109\/09513590.2013.879856","volume":"30","author":"T Nishihara","year":"2014","unstructured":"Nishihara T, Hashimoto S, Ito K, Nakaoka Y, Matsumoto K, Hosoi Y, Morimoto Y (2014) Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer. Gynecol Endocrinol 30:359\u2013362","journal-title":"Gynecol Endocrinol"},{"key":"2071_CR28","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/mrd.1080280408","volume":"28","author":"Y Noda","year":"1991","unstructured":"Noda Y, Matsumoto H, Umaoka Y, Tatsumi K, Kishi J, Mori T (1991) Involvement of superoxide radicals in the mouse two-cell block. Mol Reprod Dev 28:356\u2013360","journal-title":"Mol Reprod Dev"},{"key":"2071_CR29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3109\/09513590.2015.1101444","volume":"32","author":"A Pacchiarotti","year":"2016","unstructured":"Pacchiarotti A, Carlomagno G, Antonini G, Pacchiarotti A (2016) Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecol Endocrinol 32:69\u201373","journal-title":"Gynecol Endocrinol"},{"key":"2071_CR30","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0015-0282(16)57603-1","volume":"63","author":"GD Palermo","year":"1995","unstructured":"Palermo GD, Cohen J, Alikani M, Adler A, Rosenwaks Z (1995) Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility. Fertil Steril 63:1231\u20131240","journal-title":"Fertil Steril"},{"key":"2071_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113671","volume":"9","author":"GD Palermo","year":"2014","unstructured":"Palermo GD, Neri QV, Schlegel PN, Rosenwaks Z (2014) Intracytoplasmic sperm injection (ICSI) in extreme cases of male infertility. PLoS One 9:e113671","journal-title":"PLoS One"},{"key":"2071_CR32","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1365-2605.2011.01218.x","volume":"35","author":"P Piomboni","year":"2012","unstructured":"Piomboni P, Focarelli R, Stendardi A, Ferramosca A, Zara V (2012) The role of mitochondria in energy production for human sperm motility. Int J Androl 35:109\u2013124","journal-title":"Int J Androl"},{"key":"2071_CR33","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.18388\/abp.2003_3637","volume":"50","author":"RJ Reiter","year":"2003","unstructured":"Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z (2003) Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol 50:1129\u20131146","journal-title":"Acta Biochim Pol"},{"key":"2071_CR34","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1095\/biolreprod.108.075655","volume":"81","author":"RJ Reiter","year":"2009","unstructured":"Reiter RJ, Tan D-X, Manchester LC, Paredes SD, Mayo JC, Sainz RM (2009) Melatonin and reproduction revisited. Biol Reprod 81:445\u2013456","journal-title":"Biol Reprod"},{"key":"2071_CR35","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12360","volume":"61","author":"RJ Reiter","year":"2016","unstructured":"Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L (2016) Melatonin as an antioxidant: under promises but over delivers. J Pineal Res 61:253\u2013278","journal-title":"J Pineal Res"},{"key":"2071_CR36","first-page":"555","volume":"14","author":"P Rizzo","year":"2010","unstructured":"Rizzo P, Raffone E, Benedetto V (2010) Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci 14:555\u2013561","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2071_CR37","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1210\/jcem-71-2-493","volume":"71","author":"L R\u00f6nnberg","year":"1990","unstructured":"R\u00f6nnberg L, Kauppila A, Lepp\u00e4luoto J, Martikainen H, Vakkuri O (1990) Circadian and seasonal variation in human preovulatory follicular fluid melatonin concentration. The Journal of Clinical Endocrinology & Metabolism 71:493\u2013496","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"154\u2013161","key":"2071_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.09.036","volume":"101","author":"LM Seko","year":"2014","unstructured":"Seko LM, Moroni RM, Leitao VM, Teixeira DM, Nastri CO, Martins WP (2014) Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials. Fertil Steril 101(154\u2013161):e154","journal-title":"Fertil Steril"},{"key":"2071_CR39","first-page":"1747","volume":"80","author":"Y Shang-Mian","year":"1995","unstructured":"Shang-Mian Y, Niles P, Younglai V (1995) Melatonin receptors on human granulose cell membranes. J Clin Endocrinol Metab 80:1747\u20131749","journal-title":"J Clin Endocrinol Metab"},{"key":"2071_CR40","doi-asserted-by":"publisher","first-page":"499","DOI":"10.15296\/ijwhr.2018.82","volume":"6","author":"M Shokoohi","year":"2018","unstructured":"Shokoohi M, Madarek EOS, Khaki A, Shoorei H, Khaki AA, Soltani M, Ainehchi N (2018) Investigating the effects of onion juice on male fertility factors and pregnancy rate after testicular torsion\/detorsion by intrauterine insemination method. International Journal of Women's Health and Reproduction Sciences 6:499\u2013505","journal-title":"International Journal of Women's Health and Reproduction Sciences"},{"key":"2071_CR41","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1600-079X.2007.00524.x","volume":"44","author":"H Tamura","year":"2008","unstructured":"Tamura H, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Shimamura K (2008) Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res 44:280\u2013287","journal-title":"J Pineal Res"},{"key":"2071_CR42","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.fertnstert.2008.05.016","volume":"92","author":"H Tamura","year":"2009","unstructured":"Tamura H, Nakamura Y, Korkmaz A, Manchester LC, Tan D-X, Sugino N, Reiter RJ (2009) Melatonin and the ovary: physiological and pathophysiological implications. Fertil Steril 92:328\u2013343","journal-title":"Fertil Steril"},{"key":"2071_CR43","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1757-2215-5-5","volume":"5","author":"H Tamura","year":"2012","unstructured":"Tamura H, Takasaki A, Taketani T, Tanabe M, Kizuka F, Lee L, Tamura I, Maekawa R, Aasada H, Yamagata Y, Sugino N (2012) The role of melatonin as an antioxidant in the follicle. J Ovarian Res 5:5","journal-title":"J Ovarian Res"},{"key":"2071_CR44","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3109\/09513590.2011.564687","volume":"27","author":"V Unfer","year":"2011","unstructured":"Unfer V, Raffone E, Rizzo P, Buffo S (2011) Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. Gynecol Endocrinol 27:857\u2013861","journal-title":"Gynecol Endocrinol"},{"key":"2071_CR45","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.1210\/jcem.86.10.7912","volume":"86","author":"MM Woo","year":"2001","unstructured":"Woo MM, Tai C-J, Kang SK, Nathwani PS, Pang SF, Leung PC (2001) Direct action of melatonin in human granulosa-luteal cells. The Journal of Clinical Endocrinology & Metabolism 86:4789\u20134797","journal-title":"The Journal of Clinical Endocrinology & Metabolism"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-021-02071-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-021-02071-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-021-02071-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T16:59:23Z","timestamp":1724605163000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-021-02071-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2071"],"URL":"https:\/\/doi.org\/10.1007\/s00210-021-02071-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"type":"print","value":"0028-1298"},{"type":"electronic","value":"1432-1912"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"13 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}