{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:06:01Z","timestamp":1767139561880,"version":"build-2238731810"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007062","name":"Yangzhou University","doi-asserted-by":"publisher","award":["X20200782"],"award-info":[{"award-number":["X20200782"]}],"id":[{"id":"10.13039\/501100007062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00210-021-02076-4","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T05:59:46Z","timestamp":1616133586000},"page":"1579-1588","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibitory effects of aloperine on voltage-gated Na+ channels in rat ventricular myocytes"],"prefix":"10.1007","volume":"394","author":[{"given":"Meng-ting","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-ya","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-ru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-wei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan-tong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-zhou","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"2076_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/415213a","volume":"415","author":"E Marban","year":"2002","unstructured":"Marban E (2002) Cardiac channelopathies. Nature. 415:213\u2013218","journal-title":"Nature."},{"key":"2076_CR2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.healthpol.2008.09.003","volume":"90","author":"J Xu","year":"2009","unstructured":"Xu J, Yang Y (2009) Traditional Chinese medicine in the Chinese health care system. Health Policy 90:133\u2013139","journal-title":"Health Policy"},{"key":"2076_CR3","doi-asserted-by":"publisher","first-page":"112172","DOI":"10.1016\/j.jep.2019.112172","volume":"248","author":"R Wang","year":"2020","unstructured":"Wang R, Deng X, Gao Q, Wu X, Han L, Gao X, Zhao S, Chen W, Zhou R, Li Z, Bai C (2020a) Sophora alopecuroides L.: an ethnopharmacological, phytochemical, and pharmacological review. J Ethnopharmacol 248:112172","journal-title":"J Ethnopharmacol"},{"key":"2076_CR4","doi-asserted-by":"publisher","first-page":"111972","DOI":"10.1016\/j.ejmech.2019.111972","volume":"188","author":"Y Li","year":"2020","unstructured":"Li Y, Wang G, Liu J, Ouyang L (2020b) Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: bioactivities, structure-activity relationships and preliminary molecular mechanisms. Eur J Med Chem 188:111972","journal-title":"Eur J Med Chem"},{"issue":"2","key":"2076_CR5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/molecules25020411","volume":"25","author":"ZJ Rong","year":"2020","unstructured":"Rong ZJ, Hu GS, Lin SY, Yan T, Li N, Zhao Y, Jia JM, Wang AH (2020) Constituents from the seeds of Sophora Alopecuroides L. Molecules. 25(2):411","journal-title":"Molecules."},{"key":"2076_CR6","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.2174\/1389450120666190618125816","volume":"20","author":"HQ Wang","year":"2019","unstructured":"Wang HQ, Xia CB, Chen L, Zhao JJ, Tao WW, Zhang X, Wang JH, Gao XJ, Yong JJ, Duan JA (2019) Phytochemical information and biological activities of quinolizidine alkaloids in sophora: a comprehensive review. Curr Drug Targets 20:1572\u20131586","journal-title":"Curr Drug Targets"},{"key":"2076_CR7","doi-asserted-by":"publisher","first-page":"5518","DOI":"10.2174\/1381612821666151002112934","volume":"21","author":"M Perez","year":"2015","unstructured":"Perez M, Espadinha M, Santos-Maria MM (2015) Indolo[2,3-a] quinolizidines and derivatives: bioactivity and asymmetric synthesis. Curr Pharm Des 21:5518\u20135546","journal-title":"Curr Pharm Des"},{"key":"2076_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejphar.2009.02.013","volume":"607","author":"XL Zhao","year":"2009","unstructured":"Zhao XL, Gu DF, Qi ZP, Chen MH, Wei T, Li BX, Yang BF (2009) Comparative effects of sophocarpine and sophoridine on hERG K+ channel. Eur J Pharmacol 607:15\u201322","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"2076_CR9","doi-asserted-by":"publisher","first-page":"e0149618","DOI":"10.1371\/journal.pone.0149618","volume":"11","author":"MH Ho","year":"2016","unstructured":"Ho MH, Li H, Shawn GJ, Dong XH, Chen CH, Xie H (2016) Two ssmall molecules block oral epithelial cell invasion by Porphyromons gingivalis. PLoS One 11(2):e0149618","journal-title":"PLoS One"},{"key":"2076_CR10","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00432-020-03157-2","volume":"146","author":"T Muhammad","year":"2020","unstructured":"Muhammad T, Sakhawat A, Khan AA, Huang H, Khan HR, Huang YH, Wang J (2020) Aloperine in combination with therapeutic adenoviral vector synergistically suppressed the growth of non-small cell lung cancer. J Cancer Res Clin Oncol 146:861\u2013874","journal-title":"J Cancer Res Clin Oncol"},{"key":"2076_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13045-015-0120-x","volume":"8","author":"H Wang","year":"2015","unstructured":"Wang H, Yang S, Zhou H, Sun M, Du L, Wei M, Luo M, Huang J, Deng H, Feng Y, Huang J, Zhou Y (2015) Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms. J Hematol Oncol 8:26","journal-title":"J Hematol Oncol"},{"key":"2076_CR12","doi-asserted-by":"publisher","first-page":"173323","DOI":"10.1016\/j.ejphar.2020.173323","volume":"883","author":"XQ Lv","year":"2020","unstructured":"Lv XQ, Zou LL, Tan JL, Li H, Li JR, Liu NN, Dong B, Song DQ, Peng ZG (2020) Aloperine inhibits hepatitis C virus entry into cells by disturbing internalisation from endocytosis to the membrane fusion process. Eur J Pharmacol 883:173323","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"2076_CR13","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00011-019-01313-0","volume":"69","author":"Y Ye","year":"2020","unstructured":"Ye Y, Wang Y, Yang Y, Tao L (2020) Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4\/NF-\u03baB pathway. Inflamm Res 69(4):375\u2013383","journal-title":"Inflamm Res"},{"key":"2076_CR14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biopha.2018.09.008","volume":"108","author":"J Zhao","year":"2018","unstructured":"Zhao J, Zhang G, Li M, Luo QH, Yu L, Xu L (2018) Neuro-protective effects of aloperine in an Alzheimer\u2019s disease cellular model. Biomed Pharmacother 108:137\u2013143","journal-title":"Biomed Pharmacother"},{"key":"2076_CR15","doi-asserted-by":"crossref","first-page":"5180716","DOI":"10.1155\/2020\/5180716","volume":"2020","author":"BW Huang","year":"2020","unstructured":"Huang BW, Xiong JC, Zhao XY, Zheng YH, Zhu N (2020) Network pharmacology-based analysis of the pharmacological mechanisms of aloperine on cardiovascular disease. Evid Based Complement Alternat Med 2020:5180716","journal-title":"Evid Based Complement Alternat Med"},{"key":"2076_CR16","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000500761","volume":"104","author":"Q Mao","year":"2019","unstructured":"Mao Q, Guo FF, Liang XL, Wu YF, Lu YX (2019) Aloperine activates the PI3K\/Akt pathway and protects against coronary microembolisation-induced myocardial injury in rats. Pharmacology. 104:90\u201397","journal-title":"Pharmacology."},{"issue":"1","key":"2076_CR17","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1080\/21691401.2019.1699816","volume":"48","author":"WW Li","year":"2020","unstructured":"Li WW, Li YS, Zhao Y, Ren LN (2020a) The protective effects of aloperine against ox-LDL-induced endothelial dysfunction and inflammation in HUVECs. Artif Cells Nanomed Biotechnol 48(1):107\u2013115","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"2076_CR18","first-page":"3847","volume":"15","author":"SB Song","year":"2018","unstructured":"Song SB, Chen YM, Han F (2018) Aloperine activates the Nrf2-ARE pathway when ameliorating early brain injury in a subarachnoid hemorrhage model. Exp Ther Med 15:3847\u20133855","journal-title":"Exp Ther Med"},{"key":"2076_CR19","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3892\/etm.2016.3962","volume":"13","author":"DL Ren","year":"2017","unstructured":"Ren DL, Ma WS, Guo BZ (2017) Aloperine attenuates hydrogen peroxide-induced injury via anti-apoptotic activity and suppression of the nuclear factor-\u03baB signaling pathway. Exp Ther Med 13:315\u2013320","journal-title":"Exp Ther Med"},{"issue":"30","key":"2076_CR20","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1093\/eurheartj\/ehaa383","volume":"41","author":"D Chatterjee","year":"2020","unstructured":"Chatterjee D, Pieroni M, Fatah M, Charpentier F, Cunningham KS, Spears DA, Chatterjee D, Suna G, Bos JM, Ackerman MJ, Schulze-Bahr E, Dittmann S, Notarstefano PG, Bolognese L, Duru F, Saguner AM, Hamilton RM (2020) An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins. Eur Heart J 41(30):2878\u20132890","journal-title":"Eur Heart J"},{"issue":"42","key":"2076_CR21","doi-asserted-by":"publisher","first-page":"21236","DOI":"10.1073\/pnas.1907511116","volume":"116","author":"RW Manville","year":"2019","unstructured":"Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW (2019) KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines. Proc Natl Acad Sci U S A 116(42):21236\u201321245","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2076_CR22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ddmod.2009.07.003","volume":"6","author":"CF Kline","year":"2009","unstructured":"Kline CF, Mohler PJ (2009) From fifth business to protagonist: the complex roles of ion channel anchors in cardiac arrhythmia. Drug Discov Today Dis Model 6(3):63\u201369","journal-title":"Drug Discov Today Dis Model"},{"issue":"6","key":"2076_CR23","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.3892\/mmr.2014.2640","volume":"10","author":"BX Liu","year":"2014","unstructured":"Liu BX, Li S, Su Y, Xiong MT, Xu YW (2014) Comparative study of the protective effects of terfenadine and amiodarone on barium chloride\/aconitine-induced ventricular arrhythmias in rats: a potential role of terfenadine. Mol Med Rep 10(6):3217\u20133226","journal-title":"Mol Med Rep"},{"key":"2076_CR24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-1-4939-1096-0_19","volume":"1183","author":"R Guinamard","year":"2014","unstructured":"Guinamard R, Hof T, Sall\u00e9 L (2014) Current recordings at the single channel level in adult mammalian isolated cardiomyocytes. Methods Mol Biol 1183:291\u2013307","journal-title":"Methods Mol Biol"},{"issue":"5","key":"2076_CR25","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/15563650.2017.1291944","volume":"55","author":"JM Coulson","year":"2017","unstructured":"Coulson JM, Caparrotta TM, Thompson JP (2017) The management of ventricular dysrhythmia in aconite poisoning. Clin Toxicol (Phila) 55(5):313\u2013321","journal-title":"Clin Toxicol (Phila)"},{"key":"2076_CR26","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1161\/01.RES.81.5.727","volume":"81","author":"RM Shaw","year":"1997","unstructured":"Shaw RM, Rudy Y (1997) Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 81:727\u2013741","journal-title":"Circ Res"},{"key":"2076_CR27","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.1074\/jbc.RA117.000852","volume":"293","author":"S Molinarolo","year":"2018","unstructured":"Molinarolo S, Lee S, Leisle L (2018) Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel. J Biol Chem 293:4981\u20134992","journal-title":"J Biol Chem"},{"key":"2076_CR28","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1242\/jeb.205.5.575","volume":"205","author":"AL Goldin","year":"2002","unstructured":"Goldin AL (2002) Evolution of voltage-gated Na (+) channels. J Exp Biol 205:575\u2013584","journal-title":"J Exp Biol"},{"key":"2076_CR29","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.biopha.2017.08.126","volume":"95","author":"F Wu","year":"2017","unstructured":"Wu F, Yao WX, Yang JM (2017) Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A\/Rho kinsase pathway in rats. Biomed Pharmacother 95:1161\u20131168","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"2076_CR30","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1253\/circj.CJ-13-1586","volume":"78","author":"S Nergui","year":"2014","unstructured":"Nergui S, Fukumoto Y, Do EZ, Nakajima S, Shimizu T, Ikeda S, Elias-Al-Mamun M, Shimokawa H (2014) Role of endothelial nitric oxide synthase and collagen metabolism in right ventricular remodeling due to pulmonary hypertension. Circ J 78(6):1465\u20131474","journal-title":"Circ J"},{"key":"2076_CR31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0014-2999(98)00878-4","volume":"365","author":"HR Lu","year":"1999","unstructured":"Lu HR, Yang P, Remeysen P (1999) Ischemia\/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx. Eur J Pharmacol 365:233\u2013239","journal-title":"Eur J Pharmacol"},{"key":"2076_CR32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.yjmcc.2004.12.012","volume":"38","author":"CR Valdivia","year":"2005","unstructured":"Valdivia CR, Chu WW, Pu J (2005) Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol 38:475\u2013483","journal-title":"J Mol Cell Cardiol"},{"key":"2076_CR33","first-page":"822","volume":"7","author":"S Zhou","year":"2008","unstructured":"Zhou S, Li S, Liu Y, Liu X (2008) Sodium channel and its role in drug research progress. J Med Rep 7:822\u2013823","journal-title":"J Med Rep"},{"issue":"4","key":"2076_CR34","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.bbrc.2007.01.082","volume":"354","author":"M Fu","year":"2007","unstructured":"Fu M, Wu M, Wang JF (2007) Disruption of the entracelular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes. Biochem Biophys Res Commun 354(4):929\u2013936","journal-title":"Biochem Biophys Res Commun"},{"key":"2076_CR35","first-page":"1","volume":"0","author":"XC Wang","year":"2020","unstructured":"Wang XC, Jia QZ, Yu YL (2020b) Inhibition of the I and the activation of peak I contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs. Acta Pharmacol Sin 0:1\u20132","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2076_CR36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/00005344-199307000-00019","volume":"22","author":"HR Lu","year":"1993","unstructured":"Lu HR, De CF (1993) R 56 865, a Na+\/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo. J Cardiovasc Pharmacol 22(1):120\u2013125","journal-title":"J Cardiovasc Pharmacol"}],"updated-by":[{"DOI":"10.1007\/s00210-021-02138-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000}}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-021-02076-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-021-02076-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-021-02076-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T06:25:03Z","timestamp":1724653503000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-021-02076-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2076"],"URL":"https:\/\/doi.org\/10.1007\/s00210-021-02076-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]},"assertion":[{"value":"19 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00210-021-02138-7","URL":"https:\/\/doi.org\/10.1007\/s00210-021-02138-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of Yangzhou University Medical College approved the experimental protocols (Yangzhou, China).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}