{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:45:57Z","timestamp":1793072757745,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00210-021-02097-z","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T08:03:17Z","timestamp":1621324997000},"page":"1693-1701","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The salutary action of melatonin and betaine, given singly or concomitantly, on cisplatin-induced nephrotoxicity in mice"],"prefix":"10.1007","volume":"394","author":[{"given":"Mohammed","family":"Al Za\u2019abi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al Sabahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badreldin H.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"2097_CR1","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.fct.2006.01.013","volume":"44","author":"BH Ali","year":"2006","unstructured":"Ali BH, Al Moundhri MS (2006) Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food Chem Toxicol 44:1173\u20131183. https:\/\/doi.org\/10.1016\/j.fct.2006.01.013","journal-title":"Food Chem Toxicol"},{"key":"2097_CR2","doi-asserted-by":"publisher","first-page":"110761","DOI":"10.1016\/j.biopha.2020.110761","volume":"131","author":"BH Ali","year":"2020","unstructured":"Ali BH, Abdelrahman A, Al Suleimani Y, Manoj P, Ali H, Nemmar A, Al Za\u2019abi M, (2020a) Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats. Biomed Pharmacother 131:110761. https:\/\/doi.org\/10.1016\/j.biopha.2020.110761","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2097_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.33549\/physiolres.934142","volume":"69","author":"BH Ali","year":"2020","unstructured":"Ali BH, Al Salam S, Al Suleimani Y, Al Za\u2019abi M, Ashique M, Manoj P, Sudhadevi M, Al Tobi M, Nemmar A (2020b) Ameliorative effect of sesamin in cisplatin-induced nephrotoxicity in rats by suppressing inflammation, oxidative\/nitrosative stress, and cellular damage. Physiol Res 69(1):61\u201372. https:\/\/doi.org\/10.33549\/physiolres.934142","journal-title":"Physiol Res"},{"key":"2097_CR4","first-page":"28","volume":"7","author":"M Al Za\u2019abi","year":"2015","unstructured":"Al Za\u2019abi M, Al Busaidi M, Yasin J, Schupp N, Nemmar A, Ali BH (2015) Development of a new model for the induction of chronic kidney disease via intraperitoneal adenine administration, and the effect of treatment with gum acacia thereon. Am J Transl Res 7:28\u201338","journal-title":"Am J Transl Res"},{"key":"2097_CR5","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1159\/000488176","volume":"45","author":"M Al Za\u2019abi","year":"2018","unstructured":"Al Za\u2019abi M, Al Salam S, Al Suleimani Y, Manoj P, Nemmar A, Ali BH (2018) Gum acacia improves renal function and ameliorates systemic inflammation, oxidative and nitrosative stress in streptozotocin-induced diabetes in rats with adenine-induced chronic kidney disease. Cell Physiol Biochem 45:2293\u20132304. https:\/\/doi.org\/10.1159\/000488176","journal-title":"Cell Physiol Biochem"},{"key":"2097_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00210-020-01976-1","volume":"394","author":"M Al Za\u2019abi","year":"2021","unstructured":"Al Za\u2019abi M, Al Salam S, Al Suleimani Y, Ashique M, Manoj P, Nemmar A, Ali BH (2021) Effects of repeated increasing doses of cisplatin as models of acute kidney injury and chronic kidney disease in rats. Naunyn Schmiedebergs Arch Pharmacol 394:249\u2013259. https:\/\/doi.org\/10.1007\/s00210-020-01976-1","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2097_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/nep.13572","volume":"24","author":"F Armutcu","year":"2019","unstructured":"Armutcu F, Demircan K, Yildirim U, Namuslu M, Yagmurca M, Celik HT (2019) Hypoxia causes important changes of extracellular matrix biomarkers and ADAMTS proteinases in the adriamycininduced renal fibrosis model. Nephrology (carlton) 24:863\u2013875","journal-title":"Nephrology (carlton)"},{"key":"2097_CR8","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/antiox10020210","volume":"10","author":"MA Bonmati-Carrion","year":"2021","unstructured":"Bonmati-Carrion MA, Tomas-Loba A (2021) Melatonin and cancer: a polyhedral network where the source matters. Antioxidants (basel) 10:210. https:\/\/doi.org\/10.3390\/antiox10020210","journal-title":"Antioxidants (basel)"},{"key":"2097_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00228-019-02771-5","volume":"76","author":"AG Casanova","year":"2020","unstructured":"Casanova AG, Hern\u00e1ndez-S\u00e1nchez MT, L\u00f3pez-Hern\u00e1ndez FJ, Mart\u00ednez-Salgado C, Prieto M, Vicente-Vicente L, Morales AI (2020) Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity. Eur J Clin Pharmacol 76:23\u201333. https:\/\/doi.org\/10.1007\/s00228-019-02771-5","journal-title":"Eur J Clin Pharmacol"},{"key":"2097_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/ajcn\/80.3.539","volume":"80","author":"SA Craig","year":"2004","unstructured":"Craig SA (2004) Betaine in human nutrition. Am J Clin Nutr 80:539\u2013549. https:\/\/doi.org\/10.1093\/ajcn\/80.3.539","journal-title":"Am J Clin Nutr"},{"key":"2097_CR11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/jnc.12094","volume":"124","author":"GS Chai","year":"2013","unstructured":"Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS, Wang Q, Wang JZ, Liu GP (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124:388\u2013396. https:\/\/doi.org\/10.1111\/jnc.12094","journal-title":"J Neurochem"},{"key":"2097_CR12","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/biom10091211","volume":"10","author":"DM Chitimus","year":"2020","unstructured":"Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, Zagrean AM (2020) Melatonin\u2019s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules 10:1211. https:\/\/doi.org\/10.3390\/biom10091211","journal-title":"Biomolecules"},{"key":"2097_CR13","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3390\/antiox9060477","volume":"9","author":"G D'Angelo","year":"2020","unstructured":"D\u2019Angelo G, Chimenz R, Reiter RJ, Gitto E (2020) Use of melatonin in oxidative stress related neonatal diseases. Antioxidants (basel) 9:477. https:\/\/doi.org\/10.3390\/antiox9060477","journal-title":"Antioxidants (basel)"},{"key":"2097_CR14","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","volume":"740","author":"S Dasari","year":"2014","unstructured":"Dasari S, Tchounwou PB (2014) Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 740:364\u2013378. https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.025","journal-title":"Eur J Pharmacol"},{"key":"2097_CR15","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/ajcn\/87.2.424","volume":"87","author":"P Detopoulou","year":"2008","unstructured":"Detopoulou P, Panagiotakos DB, Antonopoulou S, Pitsavos C, Stefanadis C (2008) Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. Am J Clin Nutr 87:424\u2013430. https:\/\/doi.org\/10.1093\/ajcn\/87.2.424","journal-title":"Am J Clin Nutr"},{"key":"2097_CR16","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.fct.2018.05.032","volume":"118","author":"S Dutta","year":"2018","unstructured":"Dutta S, Saha S, Mahalanobish S, Sadhukhan P, Sil PC (2018) Melatonin attenuates arsenic induced nephropathy via the regulation of oxidative stress and inflammatory signaling cascades in mice. Food Chem Toxicol 118:303\u2013316. https:\/\/doi.org\/10.1016\/j.fct.2018.05.032","journal-title":"Food Chem Toxicol"},{"key":"2097_CR17","doi-asserted-by":"publisher","first-page":"1835195","DOI":"10.1155\/2017\/1835195","volume":"2017","author":"G Favero","year":"2017","unstructured":"Favero G, Franceschetti L, Bonomini F, Rodella LF, Rezzani R (2017) Melatonin as an anti-inflammatory agent modulating inflammasome activation. Int J Endocrinol 2017:1835195. https:\/\/doi.org\/10.1155\/2017\/1835195","journal-title":"Int J Endocrinol"},{"key":"2097_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.etp.2014.11.001","volume":"67","author":"H Hagar","year":"2015","unstructured":"Hagar H, Medany AE, Salam R, Medany GE, Nayal OA (2015) Betaine supplementation mitigates cisplatin-induced nephrotoxicity by abrogation of oxidative\/nitrosative stress and suppression of inflammation and apoptosis in rats. Exp Toxicol Pathol 67:133\u2013141. https:\/\/doi.org\/10.1016\/j.etp.2014.11.001","journal-title":"Exp Toxicol Pathol"},{"issue":"9","key":"2097_CR19","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1080\/17425255.2018.1513492","volume":"14","author":"H Haghi-Aminjan","year":"2018","unstructured":"Haghi-Aminjan H, Farhood B, Rahimifard M, Didari T, Baeeri M, Hassani S, Hosseini R, Abdollahi M (2018) The protective role of melatonin in chemotherapy-induced nephrotoxicity: a systematic review of non-clinical studies. Expert Opin Drug Metab Toxicol 14(9):937\u2013950. https:\/\/doi.org\/10.1080\/17425255.2018.1513492","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2097_CR20","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s40265-019-01182-1","volume":"79","author":"A Hamroun","year":"2019","unstructured":"Hamroun A, Lenain R, Bigna JJ, Speyer E, Bui L, Chamley P, Pottier N, Cauffiez C, Dewaeles E, Dhalluin X, Scherpereel A, Hazzan M, Maanaoui M, Glowacki F (2019) Prevention of cisplatin-induced acute kidney injury: a systematic review and meta-analysis. Drugs 79:1567\u20131582. https:\/\/doi.org\/10.1007\/s40265-019-01182-1","journal-title":"Drugs"},{"key":"2097_CR21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1034\/j.1600-079X.2001.300301.x","volume":"30","author":"M Hara","year":"2001","unstructured":"Hara M, Yoshida M, Nishijima H, Yokosuka M, Iigo M, Ohtani-Kaneko R, Shimada A, Hasegawa T, Akama Y, Hirata K (2001) Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats. J Pineal Res 30:129\u2013138","journal-title":"J Pineal Res"},{"key":"2097_CR22","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3390\/ijms20051223","volume":"20","author":"R Hardeland","year":"2019","unstructured":"Hardeland R (2019) Aging, melatonin, and the pro- and anti-inflammatory networks. Int J Mol Sci 20:1223. https:\/\/doi.org\/10.3390\/ijms20051223","journal-title":"Int J Mol Sci"},{"key":"2097_CR23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/cancers8020021","volume":"8","author":"J Hoek","year":"2016","unstructured":"Hoek J, Bloemendal KM, van der Velden LA, van Diessen JN, van Werkhoven E, Klop WM, Tesselaar ME (2016) Nephrotoxicity as a dose-limiting factor in a high-dose cisplatin-based chemoradiotherapy regimen for head and neck carcinomas. Cancers (basel) 8:21. https:\/\/doi.org\/10.3390\/cancers8020021","journal-title":"Cancers (basel)"},{"key":"2097_CR24","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1177\/37.3.2465335","volume":"37","author":"M Gascon-Barr\u00e9","year":"1989","unstructured":"Gascon-Barr\u00e9 M, Huet PM, Belgiorno J, Plourde V, Coulombe PA (1989) Estimation of collagen content of liver specimens. Variation among animals and among hepatic lobes in cirrhotic rats. J Histochem Cytochem 37:377\u2013381. https:\/\/doi.org\/10.1177\/37.3.2465335","journal-title":"J Histochem Cytochem"},{"key":"2097_CR25","doi-asserted-by":"publisher","first-page":"e00579","DOI":"10.1002\/mgg3.579","volume":"7","author":"MM Ghartavol","year":"2019","unstructured":"Ghartavol MM, Gholizadeh-Ghaleh Aziz S, Babaei G, Hossein Farjah G, Hassan Khadem Ansari M (2019) The protective impact of betaine on the tissue structure and renal function in isoproterenol-induced myocardial infarction in rat. Mol Genet Genomic Med 7:e00579","journal-title":"Mol Genet Genomic Med"},{"key":"2097_CR26","doi-asserted-by":"publisher","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","volume":"88","author":"S Ghosh","year":"2019","unstructured":"Ghosh S (2019) Cisplatin: the first metal based anticancer drug. Bioorg Chem 88:102925. https:\/\/doi.org\/10.1016\/j.bioorg.2019.102925","journal-title":"Bioorg Chem"},{"key":"2097_CR27","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s12192-019-01022-x","volume":"24","author":"F Kar","year":"2019","unstructured":"Kar F, Hacioglu C, Kacar S, Sahinturk V, Kanbak G (2019) Betaine suppresses cell proliferation by increasing oxidative stress-mediated apoptosis and inflammation in DU-145 human prostate cancer cell line. Cell Stress Chaperones 24:871\u2013881. https:\/\/doi.org\/10.1007\/s12192-019-01022-x (Epub 2019 Jul 31)","journal-title":"Cell Stress Chaperones"},{"key":"2097_CR28","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.bcp.2005.09.021","volume":"70","author":"KK Kharbanda","year":"2005","unstructured":"Kharbanda KK, Rogers DD 2nd, Mailliard ME, Siford GL, Barak AJ, Beckenhauer HC, Sorrell MF, Tuma DJ (2005) Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Biochem Pharmacol 70:1883\u20131890. https:\/\/doi.org\/10.1016\/j.bcp.2005.09.021","journal-title":"Biochem Pharmacol"},{"key":"2097_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1743-7075-10-7","volume":"10","author":"U Kilic","year":"2013","unstructured":"Kilic U, Kilic E, Tuzcu Z, Tuzcu M, Ozercan IH, Yilmaz O, Sahin F, Sahin K (2013) Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2\/HO-1 pathway. Nutr Metab (lond) 10:7","journal-title":"Nutr Metab (lond)"},{"key":"2097_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2119\/molmed.2008.00117","volume":"15","author":"A Korkmaz","year":"2009","unstructured":"Korkmaz A, Reiter RJ, Topal T, Manchester LC, Oter S, Tan DX (2009) Melatonin: an established antioxidant worthy of use in clinical trials. Mol Med 15:43\u201350. https:\/\/doi.org\/10.2119\/molmed.2008.00117","journal-title":"Mol Med"},{"key":"2097_CR31","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.clinbiochem.2010.03.009","volume":"43","author":"M Lever","year":"2010","unstructured":"Lever M, Slow S (2010) The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 43:732\u2013744. https:\/\/doi.org\/10.1016\/j.clinbiochem.2010.03.009","journal-title":"Clin Biochem"},{"key":"2097_CR32","first-page":"684","volume":"7","author":"Y Liu","year":"2011","unstructured":"Liu Y (2011) Cellular and molecular mechanisms of renal fibrosis. Nat Rev 7:684\u2013696","journal-title":"Nat Rev"},{"key":"2097_CR33","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1055\/s-0033-1360127","volume":"80","author":"YL Liu","year":"2014","unstructured":"Liu YL, Pan Y, Wang X, Fan CY, Zhu Q, Li JM, Wang SJ, Kong LD (2014) Betaine reduces serum uric acid levels and improves kidney function in hyperuricemic mice. Planta Med 80:39\u201347. https:\/\/doi.org\/10.1055\/s-0033-1360127","journal-title":"Planta Med"},{"key":"2097_CR34","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1177\/33.8.2410480","volume":"33","author":"A L\u00f3pez-De Le\u00f3n","year":"1985","unstructured":"L\u00f3pez-De Le\u00f3n A, Rojkind M (1985) A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 33:737\u2013743. https:\/\/doi.org\/10.1177\/33.8.2410480","journal-title":"J Histochem Cytochem"},{"key":"2097_CR35","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1089\/ten.tea.2011.0023","volume":"17","author":"ML Manni","year":"2011","unstructured":"Manni ML, Czajka CA, Oury TD, Gilbert TW (2011) Extracellular matrix powder protects against bleomycin-induced pulmonary fibrosis. Tissue Eng Part A 17:2795\u20132804. https:\/\/doi.org\/10.1089\/ten.tea.2011.0023","journal-title":"Tissue Eng Part A"},{"key":"2097_CR36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s40620-017-0392-z","volume":"31","author":"S Manohar","year":"2018","unstructured":"Manohar S, Leung N (2018) Cisplatin nephrotoxicity: a review of the literature. J Nephrol 31:15\u201325. https:\/\/doi.org\/10.1007\/s40620-017-0392-z","journal-title":"J Nephrol"},{"key":"2097_CR37","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jcm.2012.11.001","volume":"12","author":"MP McRae","year":"2013","unstructured":"McRae MP (2013) Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med 12:20\u201325. https:\/\/doi.org\/10.1016\/j.jcm.2012.11.001","journal-title":"J Chiropr Med"},{"key":"2097_CR38","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.3390\/toxins2112490","volume":"2","author":"RP Miller","year":"2010","unstructured":"Miller RP, Tadagavadi RK, Ramesh G, Reeves WB (2010) Mechanisms of Cisplatin Nephrotoxicity Toxins (basel) 2:2490\u20132518. https:\/\/doi.org\/10.3390\/toxins2112490","journal-title":"Mechanisms of Cisplatin Nephrotoxicity Toxins (basel)"},{"key":"2097_CR39","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1177\/1535370214564749","volume":"240","author":"A Nemmar","year":"2015","unstructured":"Nemmar A, Yuvaraju P, Beegam S, Ali BH (2015) Betaine (N, N, N-trimethylglycine) averts photochemically-induced thrombosis in pial microvessels in vivo and platelet aggregation in vitro. Exp Biol Med (maywood) 240:955\u2013960. https:\/\/doi.org\/10.1177\/1535370214564749","journal-title":"Exp Biol Med (maywood)"},{"key":"2097_CR40","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1159\/000464117","volume":"41","author":"A Nemmar","year":"2017","unstructured":"Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Oulhaj A, Ali BH (2017) Water-pipe smoke exposure-induced circulatory disturbances in mice, and the influence of betaine supplementation thereon. Cell Physiol Biochem 41:1098\u20131112. https:\/\/doi.org\/10.1159\/000464117","journal-title":"Cell Physiol Biochem"},{"key":"2097_CR41","doi-asserted-by":"publisher","unstructured":"Ozkok A, Edelstein\u00a0CL \u00a0(2014)\u00a0Pathophysiology of cisplatin-induced acute kidney injury. Biomed Res Int 2014:967826. https:\/\/doi.org\/10.1155\/2014\/967826.","DOI":"10.1155\/2014\/967826"},{"key":"2097_CR42","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/s0090-4295(03)00255-3","volume":"62","author":"F Ozturk","year":"2003","unstructured":"Ozturk F, Ucar M, Ozturk IC, Vardi N, Batcioglu K (2003) Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology 62:353\u2013356. https:\/\/doi.org\/10.1016\/s0090-4295(03)00255-3","journal-title":"Urology"},{"key":"2097_CR43","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.ki.5002786","volume":"73","author":"N Pabla","year":"2008","unstructured":"Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73:994\u20131007","journal-title":"Kidney Int"},{"key":"2097_CR44","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1177\/1534735404270936","volume":"3","author":"KN Prasad","year":"2004","unstructured":"Prasad KN (2004) Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. Integr Cancer Ther 3:310\u2013322. https:\/\/doi.org\/10.1177\/1534735404270936","journal-title":"Integr Cancer Ther"},{"key":"2097_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13813455.2020.1770799","volume":"10","author":"S Samanta","year":"2020","unstructured":"Samanta S (2020) Physiological and pharmacological perspectives of melatonin. Arch Physiol Biochem 10:1\u201322. https:\/\/doi.org\/10.1080\/13813455.2020.1770799","journal-title":"Arch Physiol Biochem"},{"key":"2097_CR46","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1097\/01.tp.0000295749.50525.bd","volume":"84","author":"A Servais","year":"2007","unstructured":"Servais A, Meas-Yedid V, Buchler M, Morelon E, Olivo-Marin JC, Lebranchu Y, Legendre C, Thervet E (2007) Quantification of interstitial fibrosis by image analysis on routine renal biopsy in patients receiving cyclosporine. Transplantation 84:1595\u20131601. https:\/\/doi.org\/10.1097\/01.tp.0000295749.50525.bd","journal-title":"Transplantation"},{"key":"2097_CR47","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12929-019-0518-9","volume":"26","author":"V Volarevic","year":"2019","unstructured":"Volarevic V, Djokovic B, Jankovic MG, Harrell R, Fellabaum C, Djonov V, Arsenijevic N (2019) Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity. J Biomed Sci 26:25","journal-title":"J Biomed Sci"},{"key":"2097_CR48","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.clnu.2018.01.042","volume":"38","author":"J Youn","year":"2019","unstructured":"Youn J, Cho E, Lee JE (2019) Association of choline and betaine levels with cancer incidence and survival: a meta-analysis. Clin Nutr 38:100\u2013109. https:\/\/doi.org\/10.1016\/j.clnu.2018.01.042","journal-title":"Clin Nutr"},{"key":"2097_CR49","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3389\/fimmu.2018.01070","volume":"9","author":"G Zhao","year":"2018","unstructured":"Zhao G, He F, Wu C, Li P, Li N, Deng J, Zhu G, Ren W, Peng Y (2018) Betaine in inflammation: mechanistic aspects and applications. Front Immunol 9:1070. https:\/\/doi.org\/10.3389\/fimmu.2018.01070","journal-title":"Front Immunol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-021-02097-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-021-02097-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-021-02097-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T07:03:39Z","timestamp":1626937419000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-021-02097-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["2097"],"URL":"https:\/\/doi.org\/10.1007\/s00210-021-02097-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"25 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was approved by the Animal Research Ethics Committee of the Sultan Qaboos University (SQU\/AEC\/2019\u201320\/11). Procedures involving animals and their care were carried out in conformity with international laws and policies (EEC Council directives 86\/609, OJL 358, December 12, 1987; NIH Guide for the Care and Use of Laboratory Animals, NIH Publications No. 85\u201323, 1985).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors read and agreed to publish this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}