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A paper by Huang et al. in this issue demonstrates that NAV2729, an inhibitor of ADP ribosylation factor 6, inhibits contraction of isolated blood vessels elicited by muscarinic receptor agonists, but not by \u03b1<jats:sub>1<\/jats:sub>-adrenoceptor agonists or KCl. Against this background, we discuss the role of ADP ribosylation factor 6 in cellular responses to G-protein-coupled receptor stimulation. While ADP ribosylation factor 6 apparently is the only promising molecular explanation for the relative resistance of smooth muscle contraction elicited by muscarinic agonists, the existing data are insufficient for a robust conclusion.<\/jats:p>","DOI":"10.1007\/s00210-022-02221-7","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T09:02:56Z","timestamp":1645088576000},"page":"381-386","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does coupling to ADP ribosylation factor 6 explain differences between muscarinic and other receptors in interaction with \u03b2-adrenoceptor-mediated smooth muscle relaxation?"],"prefix":"10.1007","volume":"395","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-4777","authenticated-orcid":false,"given":"Bet\u00fcl R.","family":"Erdogan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4161-8467","authenticated-orcid":false,"given":"Martin C.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"2221_CR1","doi-asserted-by":"publisher","first-page":"5262","DOI":"10.1128\/MCB.21.15.5262-5275.2001","volume":"21","author":"A Bose","year":"2001","unstructured":"Bose A, Cherniack AD, Langille SE, Nicoloro SM, Buxton JM, Park JG, Chawla A, Czech MP (2001) G\u03b111 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane. 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