{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:23:15Z","timestamp":1776860595327,"version":"3.51.2"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00210-022-02242-2","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T01:03:37Z","timestamp":1650330217000},"page":"827-837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Isobolographic analysis of the antidepressant interaction in two-drug combinations of citalopram, bupropion, and scopolamine in mice"],"prefix":"10.1007","volume":"395","author":[{"given":"Mohammad-Hossein","family":"Mohammadi-Mahdiabadi-Hasani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohaddeseh","family":"Ebrahimi-Ghiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Khakpai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad-Reza","family":"Zarrindast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"2242_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4088\/pcc.v02n0301","volume":"2","author":"JC Ballenger","year":"2000","unstructured":"Ballenger JC (2000) Anxiety and depression: optimizing treatments. Prim Care Companion J Clin Psychiatry 2:71\u201379. https:\/\/doi.org\/10.4088\/pcc.v02n0301","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"2242_CR2","first-page":"241","volume":"25","author":"K Bezchlibnyk-Butler","year":"2000","unstructured":"Bezchlibnyk-Butler K, Aleksic I, Kennedy SH (2000) Citalopram\u2013a review of pharmacological and clinical effects. J Psychiatry Neurosci 25:241\u2013254","journal-title":"J Psychiatry Neurosci"},{"key":"2242_CR3","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.pnpbp.2004.06.005","volume":"28","author":"MC Carrasco","year":"2004","unstructured":"Carrasco MC, Vicens P, Vidal J, Redolat R (2004) Effects of acute administration of bupropion on behavior in the elevated plus-maze test by NMRI mice. Prog Neuropsychopharmacol Biol Psychiatry 28:1135\u20131141. https:\/\/doi.org\/10.1016\/j.pnpbp.2004.06.005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2242_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/bs.apha.2020.04.002","volume":"89","author":"WC Drevets","year":"2020","unstructured":"Drevets WC, Bhattacharya A, Furey ML (2020) The antidepressant efficacy of the muscarinic antagonist scopolamine: past findings and future directions. Adv Pharmacol 89:357\u2013386. https:\/\/doi.org\/10.1016\/bs.apha.2020.04.002","journal-title":"Adv Pharmacol"},{"key":"2242_CR5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.biopsych.2009.11.021","volume":"67","author":"WC Drevets","year":"2010","unstructured":"Drevets WC, Furey ML (2010) Replication of scopolamine\u2019s antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial. Biol Psychiatry 67:432\u2013438. https:\/\/doi.org\/10.1016\/j.biopsych.2009.11.021","journal-title":"Biol Psychiatry"},{"key":"2242_CR6","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/j.1527-3458.2006.00178.x","volume":"12","author":"LP Dwoskin","year":"2006","unstructured":"Dwoskin LP, Rauhut AS, King-Pospisil KA, Bardo MT (2006) Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent. CNS Drug Rev 12:178\u2013207. https:\/\/doi.org\/10.1111\/j.1527-3458.2006.00178.x","journal-title":"CNS Drug Rev"},{"key":"2242_CR7","doi-asserted-by":"publisher","first-page":"113034","DOI":"10.1016\/j.physbeh.2020.113034","volume":"224","author":"M Ebrahimi-Ghiri","year":"2020","unstructured":"Ebrahimi-Ghiri M, Khakpai F, Zarrindast M-R (2020a) Combined treatment of scopolamine and group III mGluR antagonist, CPPG, exerts antidepressant activity without affecting anxiety-related behaviors. Physiol Behav 224:113034. https:\/\/doi.org\/10.1016\/j.physbeh.2020.113034","journal-title":"Physiol Behav"},{"key":"2242_CR8","doi-asserted-by":"publisher","first-page":"112604","DOI":"10.1016\/j.bbr.2020.112604","volume":"386","author":"M Ebrahimi-Ghiri","year":"2020","unstructured":"Ebrahimi-Ghiri M, Mohammadi-Mahdiabadi-Hasani MH, Nasehi M, Zarrindast MR (2020b) Better antidepressant efficacy of mecamylamine in combination with L-NAME than with L-arginine. Behav Brain Res 386:112604. https:\/\/doi.org\/10.1016\/j.bbr.2020.112604","journal-title":"Behav Brain Res"},{"key":"2242_CR9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1001\/2013.jamapsychiatry.60","volume":"70","author":"ML Furey","year":"2013","unstructured":"Furey ML, Drevets WC, Hoffman EM et al (2013) Potential of pretreatment neural activity in the visual cortex during emotional processing to predict treatment response to scopolamine in major depressive disorder. JAMA Psychiat 70:280\u2013290. https:\/\/doi.org\/10.1001\/2013.jamapsychiatry.60","journal-title":"JAMA Psychiat"},{"key":"2242_CR10","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/npp.2008.141","volume":"34","author":"C Grillon","year":"2009","unstructured":"Grillon C, Chavis C, Covington MF, Pine DS (2009) Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: a fear-potentiated startle study. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 34:964\u2013971. https:\/\/doi.org\/10.1038\/npp.2008.141","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"2242_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/sj.npp.1301204","volume":"32","author":"C Grillon","year":"2007","unstructured":"Grillon C, Levenson J, Pine DS (2007) A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 32:225\u2013231. https:\/\/doi.org\/10.1038\/sj.npp.1301204","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"2242_CR12","first-page":"260","volume":"15","author":"M Hern\u00e1ndez-Lozano","year":"2010","unstructured":"Hern\u00e1ndez-Lozano M, Guti\u00e9rrez-Garc\u00eda AG, Contreras CM, Alc\u00e1ntara-L\u00f3pez MG (2010) Effects of bupropion on depression, anxiety and smoking cessation. Arch Neurociencias 15:260\u2013266","journal-title":"Arch Neurociencias"},{"key":"2242_CR13","unstructured":"Horgan D, Dodd S (2011) Combination antidepressants - use by GPs and psychiatrists. Aust Fam Physician 40:397\u2013400"},{"key":"2242_CR14","unstructured":"Huecker MR, Smiley A, Saadabadi A (2021) Bupropion. Treasure Island (FL)"},{"key":"2242_CR15","doi-asserted-by":"publisher","first-page":"111","DOI":"10.31887\/DCNS.2015.17.2\/dionescu","volume":"17","author":"DF Ionescu","year":"2015","unstructured":"Ionescu DF, Rosenbaum JF, Alpert JE (2015) Pharmacological approaches to the challenge of treatment-resistant depression. Dialogues Clin Neurosci 17:111\u2013126. https:\/\/doi.org\/10.31887\/DCNS.2015.17.2\/dionescu","journal-title":"Dialogues Clin Neurosci"},{"key":"2242_CR16","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.3892\/mmr.2017.6174","volume":"15","author":"N Jia","year":"2017","unstructured":"Jia N, Zuo X, Guo C et al (2017) Synergistic antinociceptive effects of alfentanil and propofol in the formalin test. Mol Med Rep 15:1893\u20131899. https:\/\/doi.org\/10.3892\/mmr.2017.6174","journal-title":"Mol Med Rep"},{"key":"2242_CR17","doi-asserted-by":"publisher","first-page":"8631","DOI":"10.1038\/s41598-017-08953-4","volume":"7","author":"Z-L Jin","year":"2017","unstructured":"Jin Z-L, Chen X-F, Ran Y-H et al (2017) Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Sci Rep 7:8631. https:\/\/doi.org\/10.1038\/s41598-017-08953-4","journal-title":"Sci Rep"},{"key":"2242_CR18","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1176\/appi.neuropsych.11110325","volume":"24","author":"D Karaiskos","year":"2012","unstructured":"Karaiskos D, Tzavellas E, Spengos K et al (2012) Duloxetine versus citalopram and sertraline in the treatment of poststroke depression, anxiety, and fatigue. J Neuropsychiatry Clin Neurosci 24:349\u2013353. https:\/\/doi.org\/10.1176\/appi.neuropsych.11110325","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"2242_CR19","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/0091-3057(82)90055-7","volume":"16","author":"RJ Katz","year":"1982","unstructured":"Katz RJ, Sibel M (1982) Animal model of depression: tests of three structurally and pharmacologically novel antidepressant compounds. Pharmacol Biochem Behav 16:973\u2013977. https:\/\/doi.org\/10.1016\/0091-3057(82)90055-7","journal-title":"Pharmacol Biochem Behav"},{"key":"2242_CR20","doi-asserted-by":"publisher","first-page":"e13608","DOI":"10.1111\/jfbc.13608","volume":"45","author":"D Kaur","year":"2021","unstructured":"Kaur D, Shri R, Kamboj A (2021) Bioactivity-directed isolation, characterization, and quantification of an anxiolytic flavonoid from Brassica oleracea L. J Food Biochem 45:e13608. https:\/\/doi.org\/10.1111\/jfbc.13608","journal-title":"J Food Biochem"},{"key":"2242_CR21","doi-asserted-by":"publisher","first-page":"532","DOI":"10.4088\/jcp.v58n1204","volume":"58","author":"RJ Kavoussi","year":"1997","unstructured":"Kavoussi RJ, Segraves RT, Hughes AR et al (1997) Double-blind comparison of bupropion sustained release and sertraline in depressed outpatients. J Clin Psychiatry 58:532\u2013537. https:\/\/doi.org\/10.4088\/jcp.v58n1204","journal-title":"J Clin Psychiatry"},{"key":"2242_CR22","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.4088\/JCP.12m07706","volume":"73","author":"D Khajavi","year":"2012","unstructured":"Khajavi D, Farokhnia M, Modabbernia A et al (2012) Oral scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry 73:1428\u20131433. https:\/\/doi.org\/10.4088\/JCP.12m07706","journal-title":"J Clin Psychiatry"},{"key":"2242_CR23","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.neubiorev.2010.04.001","volume":"34","author":"I Klinkenberg","year":"2010","unstructured":"Klinkenberg I, Blokland A (2010) The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev 34:1307\u20131350. https:\/\/doi.org\/10.1016\/j.neubiorev.2010.04.001","journal-title":"Neurosci Biobehav Rev"},{"key":"2242_CR24","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.pbb.2013.03.019","volume":"107","author":"NR Kotagale","year":"2013","unstructured":"Kotagale NR, Tripathi SJ, Aglawe MM et al (2013) Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test. Pharmacol Biochem Behav 107:42\u201347. https:\/\/doi.org\/10.1016\/j.pbb.2013.03.019","journal-title":"Pharmacol Biochem Behav"},{"key":"2242_CR25","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4088\/JCP.v65n0308","volume":"65","author":"RW Lam","year":"2004","unstructured":"Lam RW, Hossie H, Solomons K, Yatham LN (2004) Citalopram and bupropion-SR: combining versus switching in patients with treatment-resistant depression. J Clin Psychiatry 65:337\u2013340","journal-title":"J Clin Psychiatry"},{"key":"2242_CR26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1176\/appi.ajp.162.1.146","volume":"162","author":"EJ Lenze","year":"2005","unstructured":"Lenze EJ, Mulsant BH, Shear MK et al (2005) Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial. Am J Psychiatry 162:146\u2013150. https:\/\/doi.org\/10.1176\/appi.ajp.162.1.146","journal-title":"Am J Psychiatry"},{"key":"2242_CR27","doi-asserted-by":"publisher","first-page":"492","DOI":"10.2174\/1871527316666170309142646","volume":"16","author":"AE Martin","year":"2017","unstructured":"Martin AE, Schober DA, Nikolayev A et al (2017) Further evaluation of mechanisms associated with the antidepressantlike signature of scopolamine in mice. CNS Neurol Disord Drug Targets 16:492\u2013500. https:\/\/doi.org\/10.2174\/1871527316666170309142646","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2242_CR28","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1055\/s-2007-1014505","volume":"23","author":"P Martin","year":"1990","unstructured":"Martin P, Massol J, Colin JN et al (1990) Antidepressant profile of bupropion and three metabolites in mice. Pharmacopsychiatry 23:187\u2013194. https:\/\/doi.org\/10.1055\/s-2007-1014505","journal-title":"Pharmacopsychiatry"},{"key":"2242_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000028269","volume":"58","author":"V Matto","year":"1999","unstructured":"Matto V, Allikmets L (1999) Acute and chronic citalopram treatment differently modulates rat exploratory behavior in the exploration box test: no evidence for increased anxiety or changes in the [3H]raclopride binding. Pharmacology 58:59\u201369. https:\/\/doi.org\/10.1159\/000028269","journal-title":"Pharmacology"},{"key":"2242_CR30","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1176\/jnp.16.3.315","volume":"16","author":"M Menza","year":"2004","unstructured":"Menza M, Marin H, Kaufman K et al (2004) Citalopram treatment of depression in Parkinson\u2019s disease: the impact on anxiety, disability, and cognition. J Neuropsychiatry Clin Neurosci 16:315\u2013319. https:\/\/doi.org\/10.1176\/jnp.16.3.315","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"2242_CR31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.pnpbp.2018.07.013","volume":"88","author":"A Misrani","year":"2019","unstructured":"Misrani A, Tabassum S, Chen X et al (2019) Differential effects of citalopram on sleep-deprivation-induced depressive-like behavior and memory impairments in mice. Prog Neuropsychopharmacol Biol Psychiatry 88:102\u2013111. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.07.013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2242_CR32","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1017\/S1461145709990630","volume":"13","author":"C Mombereau","year":"2010","unstructured":"Mombereau C, Gur TL, Onksen J, Blendy JA (2010) Differential effects of acute and repeated citalopram in mouse models of anxiety and depression. Int J Neuropsychopharmacol 13:321\u2013334. https:\/\/doi.org\/10.1017\/S1461145709990630","journal-title":"Int J Neuropsychopharmacol"},{"key":"2242_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-05294-0","author":"M Nasehi","year":"2019","unstructured":"Nasehi M, Mohammadi-Mahdiabadi-Hasani M-H, Ebrahimi-Ghiri M, Zarrindast M-R (2019) Additive interaction between scopolamine and nitric oxide agents on immobility in the forced swim test but not exploratory activity in the hole-board. Psychopharmacology. https:\/\/doi.org\/10.1007\/s00213-019-05294-0","journal-title":"Psychopharmacology"},{"key":"2242_CR34","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1192\/bjp.157.6.894","volume":"157","author":"AL Nyth","year":"1990","unstructured":"Nyth AL, Gottfries CG (1990) The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders. A Nordic multicentre study. Br J Psychiatry 157:894\u2013901. https:\/\/doi.org\/10.1192\/bjp.157.6.894","journal-title":"Br J Psychiatry"},{"key":"2242_CR35","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/clinchem\/40.2.288","volume":"40","author":"MJ Owens","year":"1994","unstructured":"Owens MJ, Nemeroff CB (1994) Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40:288\u2013295","journal-title":"Clin Chem"},{"key":"2242_CR36","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1177\/2045125316629071","volume":"6","author":"K Patel","year":"2016","unstructured":"Patel K, Allen S, Haque MN et al (2016) Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant. Ther Adv Psychopharmacol 6:99\u2013144. https:\/\/doi.org\/10.1177\/2045125316629071","journal-title":"Ther Adv Psychopharmacol"},{"key":"2242_CR37","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1152\/japplphysiol.01058.2002","volume":"95","author":"MF Piacentini","year":"2003","unstructured":"Piacentini MF, Clinckers R, Meeusen R et al (2003) Effect of bupropion on hippocampal neurotransmitters and on peripheral hormonal concentrations in the rat. J Appl Physiol 95:652\u2013656. https:\/\/doi.org\/10.1152\/japplphysiol.01058.2002","journal-title":"J Appl Physiol"},{"key":"2242_CR38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0893-133X(99)00092-5","volume":"22","author":"F Pollier","year":"2000","unstructured":"Pollier F, Sarre S, Aguerre S et al (2000) Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 22:64\u201376. https:\/\/doi.org\/10.1016\/S0893-133X(99)00092-5","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"2242_CR39","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s00213-004-1965-9","volume":"177","author":"R Redolat","year":"2005","unstructured":"Redolat R, G\u00f3mez MC, Vicens P, Carrasco MC (2005) Bupropion effects on aggressiveness and anxiety in OF1 male mice. Psychopharmacology 177:418\u2013427. https:\/\/doi.org\/10.1007\/s00213-004-1965-9","journal-title":"Psychopharmacology"},{"key":"2242_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/s0166-4328(03)00034-2","volume":"143","author":"N Ripoll","year":"2003","unstructured":"Ripoll N, David DJP, Dailly E et al (2003) Antidepressant-like effects in various mice strains in the tail suspension test. Behav Brain Res 143:193\u2013200. https:\/\/doi.org\/10.1016\/s0166-4328(03)00034-2","journal-title":"Behav Brain Res"},{"key":"2242_CR41","doi-asserted-by":"publisher","first-page":"388","DOI":"10.4103\/0253-7613.161260","volume":"47","author":"P Singh","year":"2015","unstructured":"Singh P, Singh TG (2015) Modulation of muscarinic system with serotonin-norepinephrine reuptake inhibitor antidepressant attenuates depression in mice. Indian J Pharmacol 47:388\u2013393. https:\/\/doi.org\/10.4103\/0253-7613.161260","journal-title":"Indian J Pharmacol"},{"key":"2242_CR42","doi-asserted-by":"publisher","first-page":"473","DOI":"10.4088\/jcp.v64n0419","volume":"64","author":"CN Soares","year":"2003","unstructured":"Soares CN, Poitras JR, Prouty J et al (2003) Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms. J Clin Psychiatry 64:473\u2013479. https:\/\/doi.org\/10.4088\/jcp.v64n0419","journal-title":"J Clin Psychiatry"},{"key":"2242_CR43","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4088\/pcc.v06n0403","volume":"6","author":"SM Stahl","year":"2004","unstructured":"Stahl SM, Pradko JF, Haight BR et al (2004) A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor. Prim Care Companion J Clin Psychiatry 6:159\u2013166. https:\/\/doi.org\/10.4088\/pcc.v06n0403","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"2242_CR44","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1006\/bulm.1997.0009","volume":"60","author":"J S\u00fchnel","year":"1998","unstructured":"S\u00fchnel J (1998) Parallel dose-response curves in combination experiments. Bull Math Biol 60:197\u2013213. https:\/\/doi.org\/10.1006\/bulm.1997.0009","journal-title":"Bull Math Biol"},{"key":"2242_CR45","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","volume":"163","author":"MH Trivedi","year":"2006","unstructured":"Trivedi MH, Rush AJ, Wisniewski SR et al (2006) Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 163:28\u201340. https:\/\/doi.org\/10.1176\/appi.ajp.163.1.28","journal-title":"Am J Psychiatry"},{"key":"2242_CR46","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.indcrop.2015.01.025","volume":"67","author":"S Wang","year":"2015","unstructured":"Wang S, Wang D, Liu Z (2015) Synergistic, additive and antagonistic effects of Potentilla fruticosa combined with EGb761 on antioxidant capacities and the possible mechanism. Ind Crops Prod 67:227\u2013238. https:\/\/doi.org\/10.1016\/j.indcrop.2015.01.025","journal-title":"Ind Crops Prod"},{"key":"2242_CR47","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s40263-016-0314-y","volume":"30","author":"M Zimmerman","year":"2016","unstructured":"Zimmerman M, Multach M, Walsh E et al (2016) Problems in the descriptions of the psychiatric inclusion and exclusion criteria in publications of antidepressant efficacy trials: a qualitative review and recommendations for improved clarity. CNS Drugs 30:185\u2013191. https:\/\/doi.org\/10.1007\/s40263-016-0314-y","journal-title":"CNS Drugs"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02242-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-022-02242-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02242-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:21:22Z","timestamp":1655079682000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-022-02242-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["2242"],"URL":"https:\/\/doi.org\/10.1007\/s00210-022-02242-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1329278\/v1","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"assertion":[{"value":"9 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted under experimental protocols approved by the Animal Care and Research Ethics Committee of Tehran University of Medical Sciences, Tehran, Iran. Housing and experimental procedures were conducted under the Guide for the Care and Use of Laboratory Animals (National Institutes of Health Publication No. 85\u201323, revised 2010).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}