{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:47:16Z","timestamp":1784580436875,"version":"3.55.0"},"reference-count":144,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00210-022-02273-9","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T08:05:06Z","timestamp":1658736306000},"page":"1189-1207","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of rosmarinic acid against myocardial infarction in maternally separated rats"],"prefix":"10.1007","volume":"395","author":[{"given":"Himanshu","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindita","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Shivavedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-5633","authenticated-orcid":false,"given":"Prasanta Kumar","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"2273_CR1","doi-asserted-by":"crossref","unstructured":"Abelaira HM, Rosa T, De Moura AB, Andrade NM, Martinello NS, Maciel LR, Botelho ME M, Borba LA, Chede BC, Arent CO (2022) Combination of electroconvulsive stimulation with ketamine or escitalopram protects the brain against inflammation and oxidative stress induced by maternal deprivation and is critical for associated behaviors in male and female rats. Mol Neurobiol 1\u201324","DOI":"10.1007\/s12035-021-02718-x"},{"key":"2273_CR2","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.tiv.2017.01.016","volume":"40","author":"AG Adomako-Bonsu","year":"2017","unstructured":"Adomako-Bonsu AG, Chan SL, Pratten M, Fry JR (2017) Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: importance of physico-chemical characteristics. Toxicol in Vitro 40:248\u2013255","journal-title":"Toxicol in Vitro"},{"key":"2273_CR3","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.psyneuen.2006.12.013","volume":"32","author":"B Aisa","year":"2007","unstructured":"Aisa B, Tordera R, Lasheras B, Del R\u00edo J, Ram\u00edrez MJ (2007) Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 32:256\u2013266","journal-title":"Psychoneuroendocrinology"},{"key":"2273_CR4","first-page":"33","volume":"2","author":"HS Alnahdi","year":"2012","unstructured":"Alnahdi HS (2012) Effect of Rosmarinus officinalis extract on some cardiac enzymes of streptozotocin-induced diabetic rats.\u00a0J Health Sci\u00a02:33\u201337","journal-title":"Journal of Health Sciences"},{"key":"2273_CR5","unstructured":"Al-Sereiti M, Abu-Amer K & Sena P (1999)&nbsp;Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials."},{"key":"2273_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.physbeh.2016.04.052","volume":"163","author":"S Amiri","year":"2016","unstructured":"Amiri S, Amini-Khoei H, Mohammadi-Asl A, Alijanpour S, Haj-Mirzaian A, Rahimi-Balaei M, Razmi A, Olson CO, Rastegar M, Mehdizadeh M (2016) Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse. Physiol Behav 163:107\u2013114","journal-title":"Physiol Behav"},{"key":"2273_CR7","first-page":"509","volume":"15","author":"A Arabameri","year":"2017","unstructured":"Arabameri A, Sameni H, Bandegi A (2017) The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress.\u00a0Int\u00a0J Reprod\u00a0Biomed\u00a015:509","journal-title":"International Journal of Reproductive BioMedicine"},{"key":"2273_CR8","doi-asserted-by":"publisher","first-page":"107436","DOI":"10.1016\/j.intimp.2021.107436","volume":"93","author":"M Arabi","year":"2021","unstructured":"Arabi M, Nasab SH, Lorigooini Z, Boroujeni SN, Mortazavi SM, Anjomshoa M, Amini-Khoei H (2021) Auraptene exerts protective effects on maternal separation stress-induced changes in behavior, hippocampus, heart and serum of mice. Int Immunopharmacol 93:107436","journal-title":"Int Immunopharmacol"},{"key":"2273_CR9","first-page":"1296","volume":"280","author":"H Arakawa","year":"1997","unstructured":"Arakawa H, Kodama H, Matsuoka N, Yamaguchi I (1997) Stress increases plasma enzyme activity in rats: differential effects of adrenergic and cholinergic blockades. J Pharmacol Exp Ther 280:1296\u20131303","journal-title":"J Pharmacol Exp Ther"},{"key":"2273_CR10","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1093\/scan\/nsu073","volume":"10","author":"L Banihashemi","year":"2015","unstructured":"Banihashemi L, Sheu LK, Midei AJ, Gianaros PJ (2015) Childhood physical abuse predicts stressor-evoked activity within central visceral control regions.\u00a0Soc Cogn Affect Neurosci\u00a010:474\u2013485","journal-title":"Social Cognitive and Affective Neuroscience"},{"key":"2273_CR11","doi-asserted-by":"publisher","DOI":"10.4324\/9781351309004","volume-title":"Mothers in prison","author":"PJ Baunach","year":"2020","unstructured":"Baunach PJ (2020) Mothers in prison. Routledge"},{"key":"2273_CR12","doi-asserted-by":"publisher","first-page":"112545","DOI":"10.1016\/j.biopha.2021.112545","volume":"146","author":"T Behl","year":"2022","unstructured":"Behl T, Rana T, Alotaibi GH, Shamsuzzaman M, Naqvi M, Sehgal A, Singh S, Sharma N, Almoshari Y, Abdellatif AA (2022) Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression. Biomed Pharmacother 146:112545","journal-title":"Biomed Pharmacother"},{"key":"2273_CR13","doi-asserted-by":"publisher","first-page":"174361","DOI":"10.1016\/j.ejphar.2021.174361","volume":"908","author":"A Bhattacharjee","year":"2021","unstructured":"Bhattacharjee A, Prajapati SK, Krishnamurthy S (2021) Supplementation of taurine improves ionic homeostasis and mitochondrial function in the rats exhibiting post-traumatic stress disorder-like symptoms. Eur J Pharmacol 908:174361","journal-title":"Eur J Pharmacol"},{"key":"2273_CR14","doi-asserted-by":"crossref","unstructured":"Bian Y, Yang L, Wang Z, Wang Q, Zeng L, Xu G (2015) Repeated three-hour maternal separation induces depression-like behavior and affects the expression of hippocampal plasticity-related proteins in C57BL\/6N mice. Neural Plast 2015:627837","DOI":"10.1155\/2015\/627837"},{"key":"2273_CR15","unstructured":"Bugajski J, Turon M, Gadek-Michalska A & Borycz J (1991)&nbsp;Catecholaminergic regulation of the hypothalamic-pituitary-adrenocortical activity.\u00a0J Physiol Pharmacol\u00a042"},{"key":"2273_CR16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fpsyt.2019.00160","volume":"10","author":"K Cao","year":"2019","unstructured":"Cao K, Shen C, Yuan Y, Bai S, Yang L, Guo L, Zhang R, Shi Y (2019) SiNiSan ameliorates the depression-like behavior of rats that experienced maternal separation through 5-HT1A receptor\/CREB\/BDNF pathway. Front Psych 10:160","journal-title":"Front Psych"},{"key":"2273_CR17","doi-asserted-by":"crossref","unstructured":"Caruso G, Grasso M, Fidilio A, Torrisi SA, Musso N, Geraci F, Tropea MR, Privitera A, Tascedda F & Puzzo D (2021) &nbsp;Antioxidant activity of fluoxetine and vortioxetine in a non-transgenic animal model of Alzheimer\u2019s disease.\u00a0Front Pharmacol\u00a012","DOI":"10.3389\/fphar.2021.809541"},{"key":"2273_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0006-8993(95)01469-1","volume":"712","author":"P Celada","year":"1996","unstructured":"Celada P, Siuciak JA, Tran TM, Altar CA, Tepper JM (1996) Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphe serotonergic neurons. Brain Res 712:293\u2013298","journal-title":"Brain Res"},{"key":"2273_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.11.017","volume":"90","author":"O Chen","year":"2016","unstructured":"Chen O, Ye Z, Cao Z, Manaenko A, Ning K, Zhai X, Zhang R, Zhang T, Chen X, Liu W (2016) Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free Radical Biol Med 90:1\u201311","journal-title":"Free Radical Biol Med"},{"key":"2273_CR20","doi-asserted-by":"publisher","first-page":"5909","DOI":"10.1021\/jf0257042","volume":"50","author":"KN Chidambara Murthy","year":"2002","unstructured":"Chidambara Murthy KN, Singh RP, Jayaprakasha GK (2002) Antioxidant activities of grape (Vitis vinifera) pomace extracts. J Agric Food Chem 50:5909\u20135914","journal-title":"J Agric Food Chem"},{"key":"2273_CR21","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1177\/0960327120916821","volume":"39","author":"I Cinar","year":"2020","unstructured":"Cinar I, Halici Z, Dincer B, Sirin B, Cadirci E (2020) The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction. Hum Exp Toxicol 39:1005\u20131018","journal-title":"Hum Exp Toxicol"},{"key":"2273_CR22","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jpeds.2012.07.045","volume":"162","author":"L Cohen","year":"2013","unstructured":"Cohen L, Brown J, Haukness H, Walsh L, Robinson JK (2013) Sun protection counseling by pediatricians has little effect on parent and child sun protection behavior. J Pediatr 162:381\u2013386","journal-title":"J Pediatr"},{"key":"2273_CR23","doi-asserted-by":"publisher","first-page":"105060","DOI":"10.1016\/j.psyneuen.2020.105060","volume":"124","author":"GK Crombie","year":"2021","unstructured":"Crombie GK, Palliser HK, Shaw JC, Hodgson DM, Walker DW, Hirst JJ (2021) Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period. Psychoneuroendocrinology 124:105060","journal-title":"Psychoneuroendocrinology"},{"key":"2273_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1023\/B:MEBR.0000027412.19664.b3","volume":"19","author":"W Daniels","year":"2004","unstructured":"Daniels W, Pietersen C, Carstens M, Stein D (2004) Maternal separation in rats leads to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor. Metab Brain Dis 19:3\u201314","journal-title":"Metab Brain Dis"},{"key":"2273_CR25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1177\/1077559505275116","volume":"10","author":"MD De Bellis","year":"2005","unstructured":"De Bellis MD (2005) The psychobiology of neglect. Child Maltreat 10:150\u2013172","journal-title":"Child Maltreat"},{"key":"2273_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1161\/01.CIR.101.1.33","volume":"101","author":"S Dieterich","year":"2000","unstructured":"Dieterich S, Bieligk U, Beulich K, Hasenfuss G, Prestle J (2000) Gene expression of antioxidative enzymes in the human heart: increased expression of catalase in the end-stage failing heart. Circulation 101:33\u201339","journal-title":"Circulation"},{"key":"2273_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-27604-x","volume":"13","author":"L Dion-Albert","year":"2022","unstructured":"Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Daigle B, Parise LF, Cathomas F, Samba N, Hudson N (2022) Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Nat Commun 13:1\u201318","journal-title":"Nat Commun"},{"key":"2273_CR28","doi-asserted-by":"publisher","first-page":"104673","DOI":"10.1016\/j.psyneuen.2020.104673","volume":"116","author":"F Donoso","year":"2020","unstructured":"Donoso F, Egerton S, Bastiaanssen TF, Fitzgerald P, Gite S, Fouhy F, Ross RP, Stanton C, Dinan TG, Cryan JF (2020) Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat. Psychoneuroendocrinology 116:104673","journal-title":"Psychoneuroendocrinology"},{"key":"2273_CR29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1176\/ajp.156.3.379","volume":"156","author":"N Draijer","year":"1999","unstructured":"Draijer N, Langeland W (1999) Childhood trauma and perceived parental dysfunction in the etiology of dissociative symptoms in psychiatric inpatients. Am J Psychiatry 156:379\u2013385","journal-title":"Am J Psychiatry"},{"key":"2273_CR30","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1111\/j.1749-6632.2000.tb05426.x","volume":"917","author":"AJ Dunn","year":"2000","unstructured":"Dunn AJ (2000) Cytokine activation of the HPA axis. Ann N Y Acad Sci 917:608\u2013617","journal-title":"Ann N Y Acad Sci"},{"key":"2273_CR31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"2273_CR32","doi-asserted-by":"publisher","first-page":"110139","DOI":"10.1016\/j.pnpbp.2020.110139","volume":"105","author":"GN Erjavec","year":"2021","unstructured":"Erjavec GN, Sagud M, Perkovic MN, Strac DS, Konjevod M, Tudor L, Uzun S, Pivac N (2021) Depression: biological markers and treatment. Prog Neuropsychopharmacol Biol Psychiatry 105:110139","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2273_CR33","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/s12031-012-9790-9","volume":"48","author":"S Fargali","year":"2012","unstructured":"Fargali S, Sadahiro M, Jiang C, Frick AL, Indall T, Cogliani V, Welagen J, Lin W-J, Salton SR (2012) Role of neurotrophins in the development and function of neural circuits that regulate energy homeostasis. J Mol Neurosci 48:654\u2013659","journal-title":"J Mol Neurosci"},{"key":"2273_CR34","doi-asserted-by":"publisher","first-page":"R259","DOI":"10.1152\/ajpregu.00317.2002","volume":"284","author":"RB Felder","year":"2003","unstructured":"Felder RB, Francis J, Zhang Z-H, Wei S-G, Weiss RM, Johnson AK (2003) Heart failure and the brain: new perspectives. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 284:R259\u2013R276","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"2273_CR35","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0014-2999(92)90123-L","volume":"214","author":"A Flugy","year":"1992","unstructured":"Flugy A, Gagliano M, Cannizzaro C, Novara V, Cannizzaro G (1992) Antidepressant and anxiolytic effects of alprazolam versus the conventional. antidepressant desipramine and the anxiolytic diazepam in the forced swim test in rats. Eur J Pharmacol 214:233\u2013238","journal-title":"Eur J Pharmacol"},{"key":"2273_CR36","first-page":"1517","volume":"317","author":"MJ Friedrich","year":"2017","unstructured":"Friedrich MJ (2017) Depression is the leading cause of disability around the world. JAMA 317:1517\u20131517","journal-title":"JAMA"},{"key":"2273_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jflm.2014.09.011","volume":"28","author":"PS Ghormade","year":"2014","unstructured":"Ghormade PS, Kumar NB, Tingne CV, Keoliya AN (2014) Distribution & diagnostic efficacy of cardiac markers CK-MB & LDH in pericardial fluid for postmortem diagnosis of ischemic heart disease. J Forensic Leg Med 28:42\u201346","journal-title":"J Forensic Leg Med"},{"key":"2273_CR38","doi-asserted-by":"publisher","first-page":"4581","DOI":"10.1021\/jf000404a","volume":"48","author":"MI Gil","year":"2000","unstructured":"Gil MI, Tom\u00e1s-Barber\u00e1n FA, Hess-Pierce B, Holcroft DM, Kader AA (2000) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48:4581\u20134589","journal-title":"J Agric Food Chem"},{"key":"2273_CR39","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/0887-8994(96)00153-1","volume":"15","author":"EE Gilles","year":"1996","unstructured":"Gilles EE, Schultz L, Baram TZ (1996) Abnormal corticosterone regulation in an immature rat model of continuous chronic stress. Pediatr Neurol 15:114\u2013119","journal-title":"Pediatr Neurol"},{"key":"2273_CR40","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00406-005-0578-6","volume":"255","author":"AS Gonul","year":"2005","unstructured":"Gonul AS, Akdeniz F, Taneli F, Donat O, Eker \u00c7, Vahip S (2005) Effect of treatment on serum brain\u2013derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 255:381\u2013386","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2273_CR41","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/cvr\/cvp090","volume":"83","author":"R Granata","year":"2009","unstructured":"Granata R, Trovato L, Gallo MP, Destefanis S, Settanni F, Scarlatti F, Brero A, Ramella R, Volante M, Isgaard J (2009) Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia\u2013reperfusion injury in rat heart. Cardiovasc Res 83:303\u2013312","journal-title":"Cardiovasc Res"},{"key":"2273_CR42","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1037\/pha0000310","volume":"28","author":"T Hanania","year":"2020","unstructured":"Hanania T, Manfredi P, Inturrisi C, Vitolo OV (2020) The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats. Exp Clin Psychopharmacol 28:196","journal-title":"Exp Clin Psychopharmacol"},{"key":"2273_CR43","doi-asserted-by":"publisher","first-page":"536","DOI":"10.7150\/ijbs.10754","volume":"11","author":"P Hang","year":"2015","unstructured":"Hang P, Zhao J, Cai B, Tian S, Huang W, Guo J, Sun C, Li Y, Du Z (2015) Brain-derived neurotrophic factor regulates TRPC3\/6 channels and protects against myocardial infarction in rodents. Int J Biol Sci 11:536","journal-title":"Int J Biol Sci"},{"key":"2273_CR44","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/gbb.12277","volume":"15","author":"A Harris","year":"2016","unstructured":"Harris A, Lennen RJ, Brydges N, Jansen M, Pernet C, Whalley H, Marshall I, Baker S, Basso A, Day M (2016) The role of brain-derived neurotrophic factor in learned fear processing: an awake rat fMRI study. Genes Brain Behav 15:221\u2013230","journal-title":"Genes Brain Behav"},{"key":"2273_CR45","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/dev.420270804","volume":"27","author":"MA Hofer","year":"1994","unstructured":"Hofer MA, Brunelli SA, Shair HN (1994) Potentiation of isolation-induced vocalization by brief exposure of rat pups to maternal cues. Dev Psychobiol: the J Int Soc Dev Psychobiol 27:503\u2013517","journal-title":"Dev Psychobiol: the J Int Soc Dev Psychobiol"},{"key":"2273_CR46","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/SHK.0b013e318278ae36","volume":"39","author":"O Huet","year":"2013","unstructured":"Huet O, Laemmel E, Fu Y, Dupic L, Aprico A, Andrews KL, Moore SL, Harrois A, Meikle PL, Vicaut E (2013) Interleukin 10 antioxidant effect decreases leukocytes\/endothelial interaction induced by tumor necrosis factor \u03b1. Shock 39:83\u201388","journal-title":"Shock"},{"key":"2273_CR47","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.phymed.2010.08.011","volume":"18","author":"NF Idayu","year":"2011","unstructured":"Idayu NF, Hidayat MT, Moklas M, Sharida F, Raudzah AN, Shamima A, Apryani E (2011) Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. Phytomedicine 18:402\u2013407","journal-title":"Phytomedicine"},{"key":"2273_CR48","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"O Ighodaro","year":"2018","unstructured":"Ighodaro O, Akinloye O (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med 54:287\u2013293","journal-title":"Alexandria J Med"},{"key":"2273_CR49","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1248\/bpb.31.1376","volume":"31","author":"N Ito","year":"2008","unstructured":"Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T (2008) Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. Biol Pharm Bull 31:1376\u20131380","journal-title":"Biol Pharm Bull"},{"key":"2273_CR50","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1080\/10715762.2017.1390227","volume":"51","author":"S Javidanpour","year":"2017","unstructured":"Javidanpour S, Dianat M, Badavi M, Mard SA (2017) The cardioprotective effect of rosmarinic acid on acute myocardial infarction and genes involved in Ca2+ homeostasis. Free Radical Res 51:911\u2013923","journal-title":"Free Radical Res"},{"key":"2273_CR51","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1007\/s11064-013-1088-y","volume":"38","author":"X Jin","year":"2013","unstructured":"Jin X, Liu P, Yang F, Zhang Y-H, Miao D (2013) Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochem Res 38:1828\u20131837","journal-title":"Neurochem Res"},{"key":"2273_CR52","doi-asserted-by":"crossref","unstructured":"Jugdutt BI & Jugdutt BA (2019)&nbsp;Role of oxidative stress in myocardial ischemia and infarction. Oxidative Stress in Heart Diseases. Springer","DOI":"10.1007\/978-981-13-8273-4_14"},{"key":"2273_CR53","doi-asserted-by":"publisher","first-page":"379","DOI":"10.4093\/dmj.2020.0008","volume":"45","author":"I Jung","year":"2021","unstructured":"Jung I, Kwon H, Park SE, Han K-D, Park Y-G, Kim Y-H, Rhee E-J, Lee W-Y (2021) Increased risk of cardiovascular disease and mortality in patients with diabetes and coexisting depression: a nationwide population-based cohort study. Diabetes Metab J 45:379\u2013389","journal-title":"Diabetes Metab J"},{"key":"2273_CR54","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0304-3940(02)00529-3","volume":"328","author":"F Karege","year":"2002","unstructured":"Karege F, Schwald M, Cisse M (2002) Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328:261\u2013264","journal-title":"Neurosci Lett"},{"key":"2273_CR55","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.repbio.2019.10.003","volume":"19","author":"K Khodamoradi","year":"2019","unstructured":"Khodamoradi K, Amini-Khoei H, Khosravizadeh Z, Hosseini SR, Dehpour AR, Hassanzadeh G (2019) Oxidative stress, inflammatory reactions and apoptosis mediated the negative effect of chronic stress induced by maternal separation on the reproductive system in male mice. Reprod Biol 19:340\u2013348","journal-title":"Reprod Biol"},{"key":"2273_CR56","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S0022-3999(02)00309-4","volume":"53","author":"JK Kiecolt-Glaser","year":"2002","unstructured":"Kiecolt-Glaser JK, Glaser R (2002) Depression and immune function: central pathways to morbidity and mortality. J Psychosom Res 53:873\u2013876","journal-title":"J Psychosom Res"},{"key":"2273_CR57","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.bbi.2005.09.003","volume":"20","author":"N Koldzic-Zivanovic","year":"2006","unstructured":"Koldzic-Zivanovic N, Tu H, Juelich TL, Rady PL, Tyring SK, Hudnall SD, Smith EM, Hughes TK (2006) Regulation of adrenal glucocorticoid synthesis by interleukin-10: a preponderance of IL-10 receptor in the adrenal zona fasciculata. Brain Behav Immun 20:460\u2013468","journal-title":"Brain Behav Immun"},{"key":"2273_CR58","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","volume":"104","author":"P Krishnamurthy","year":"2009","unstructured":"Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, Kishore R (2009) IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res 104:e9\u2013e18","journal-title":"Circ Res"},{"key":"2273_CR59","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.biopha.2017.08.109","volume":"95","author":"M Kumar","year":"2017","unstructured":"Kumar M, Nayak PK (2017) Psychological sequelae of myocardial infarction. Biomed Pharmacother 95:487\u2013496","journal-title":"Biomed Pharmacother"},{"key":"2273_CR60","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00011-016-0944-z","volume":"65","author":"M Kumar","year":"2016","unstructured":"Kumar M, Kasala ER, Bodduluru LN, Dahiya V, Lahkar M (2016) Baicalein protects isoproterenol induced myocardial ischemic injury in male Wistar rats by mitigating oxidative stress and inflammation. Inflamm Res 65:613\u2013622","journal-title":"Inflamm Res"},{"key":"2273_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jbt.21832","volume":"31","author":"M Kumar","year":"2017","unstructured":"Kumar M, Kasala ER, Bodduluru LN, Kumar V, Lahkar M (2017) Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol-induced acute myocardial injury in rats. J Biochem Mol Toxicol 31:1\u20138","journal-title":"J Biochem Mol Toxicol"},{"key":"2273_CR62","doi-asserted-by":"crossref","unstructured":"K\u00fcpeli Akkol E, G\u00fcra\u011fa\u00e7 Dereli FT & Ilhan M (2019)&nbsp;Assessment of antidepressant effect of the aerial parts of micromeria myrtifolia Boiss. & Hohen on mice. Molecules\u00a024:1869","DOI":"10.3390\/molecules24101869"},{"key":"2273_CR63","first-page":"613","volume":"65","author":"S Kwiecien","year":"2014","unstructured":"Kwiecien S, Jasnos K, Magierowski M, Sliwowski Z, Pajdo R, Brzozowski B, Mach T, Wojcik D, Brzozowski T (2014) Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress-induced gastric injury. J Physiol Pharmacol 65:613\u2013622","journal-title":"J Physiol Pharmacol"},{"key":"2273_CR64","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.psyneuen.2004.12.004","volume":"30","author":"CO Ladd","year":"2005","unstructured":"Ladd CO, Thrivikraman K, Huot RL, Plotsky PM (2005) Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling-maternal separation as neonates. Psychoneuroendocrinology 30:520\u2013533","journal-title":"Psychoneuroendocrinology"},{"key":"2273_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2891-7-2","volume":"7","author":"SE Lakhan","year":"2008","unstructured":"Lakhan SE, Vieira KF (2008) Nutritional therapies for mental disorders. Nutr J 7:1\u20138","journal-title":"Nutr J"},{"key":"2273_CR66","doi-asserted-by":"publisher","first-page":"231","DOI":"10.4306\/pi.2010.7.4.231","volume":"7","author":"B-H Lee","year":"2010","unstructured":"Lee B-H, Kim Y-K (2010) The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investig 7:231","journal-title":"Psychiatry Investig"},{"key":"2273_CR67","doi-asserted-by":"crossref","unstructured":"Leenen FH (2007) &nbsp;Brain mechanisms contributing to sympathetic hyperactivity and heart failure. Am Heart Assoc","DOI":"10.1161\/CIRCRESAHA.107.158261"},{"key":"2273_CR68","doi-asserted-by":"crossref","unstructured":"Lehnen AM, Rodrigues B, Irigoyen MC, De Angelis K, Schaan BDA (2013) Cardiovascular changes in animal models of metabolic syndrome. J Diabetes Res 2013:761314","DOI":"10.1155\/2013\/761314"},{"key":"2273_CR69","doi-asserted-by":"publisher","first-page":"763","DOI":"10.2147\/DDDT.S75863","volume":"9","author":"J Liang","year":"2015","unstructured":"Liang J, Yuan X, Shi S, Wang F, Chen Y, Qu C, Chen J, Hu D, Yang B (2015) Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression. Drug Des Dev Ther 9:763","journal-title":"Drug Des Dev Ther"},{"key":"2273_CR70","doi-asserted-by":"publisher","unstructured":"Lin D, Wang L, Yan S, Zhang Q, Zhang JH, Shao A (2019) The role of oxidative stress in common risk factors and mechanisms of cardio-cerebrovascular ischemia and depression. Oxidative Med Cell Longev.\u00a0https:\/\/doi.org\/10.1155\/2019\/2491927","DOI":"10.1155\/2019\/2491927"},{"key":"2273_CR71","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.psyneuen.2016.11.031","volume":"76","author":"D Lindqvist","year":"2017","unstructured":"Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L (2017) Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology 76:197\u2013205","journal-title":"Psychoneuroendocrinology"},{"key":"2273_CR72","doi-asserted-by":"crossref","unstructured":"Lippi G, Montagnana M, Favaloro EJ & Franchini M (2009) Mental depression and cardiovascular disease: a multifaceted, bidirectional association. Seminars in thrombosis and hemostasis &nbsp;\u00a9 Thieme Medical Publishers 325\u2013336","DOI":"10.1055\/s-0029-1222611"},{"key":"2273_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/hm.hm_12_21","volume":"5","author":"M Liu","year":"2021","unstructured":"Liu M (2021) Spotlight on the relationship between heart disease and mental stress. Heart and Mind 5:1","journal-title":"Heart and Mind"},{"key":"2273_CR74","doi-asserted-by":"publisher","first-page":"113172","DOI":"10.1016\/j.psychres.2020.113172","volume":"290","author":"CH Liu","year":"2020","unstructured":"Liu CH, Zhang E, Wong GTF, Hyun S (2020) Factors associated with depression, anxiety, and PTSD symptomatology during the COVID-19 pandemic: clinical implications for US young adult mental health. Psychiatry Res 290:113172","journal-title":"Psychiatry Res"},{"issue":"18","key":"2273_CR75","first-page":"193","volume":"1973\u20132006","author":"KB Livezey","year":"1990","unstructured":"Livezey KB (1990) Toward the reduction of marking-induced abandonment of newborn ungulates. Wildl Soc Bull 1973\u20132006(18):193\u2013203","journal-title":"Wildl Soc Bull"},{"key":"2273_CR76","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1097\/PSY.0b013e3181ba18ed","volume":"71","author":"CA Low","year":"2009","unstructured":"Low CA, Salomon K, Matthews KA (2009) Chronic life stress, cardiovascular reactivity, and subclinical cardiovascular disease in adolescents. Psychosom Med 71:927","journal-title":"Psychosom Med"},{"key":"2273_CR77","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neures.2008.01.011","volume":"61","author":"L Marais","year":"2008","unstructured":"Marais L, Van Rensburg SJ, Van Zyl JM, Stein DJ, Daniels WM (2008) Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neurosci Res 61:106\u2013112","journal-title":"Neurosci Res"},{"key":"2273_CR78","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1152\/ajplegacy.1971.221.3.896","volume":"221","author":"HY Meltzer","year":"1971","unstructured":"Meltzer HY (1971) Plasma creatine phosphokinase activity, hypothermia, and stress. American Journal of Physiology-Legacy Content 221:896\u2013901","journal-title":"American Journal of Physiology-Legacy Content"},{"key":"2273_CR79","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4172\/2168-9652.1000210","volume":"5","author":"E Metias","year":"2016","unstructured":"Metias E, Aboelmaaty N, Hussein A, Abdallah E, Abdelaziz A (2016) Modulation of ECG, myocardial oxidative stress markers and connexion 43 expression by ascorbic acid and ferulic acid in isoproterenol-induced myocardial infarction in rats. Biochem Physiol 5:2","journal-title":"Biochem Physiol"},{"key":"2273_CR80","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1742-7843.2004.pto940405.x","volume":"94","author":"I Mohanty","year":"2004","unstructured":"Mohanty I, Arya DS, Dinda A, Talwar KK, Joshi S, Gupta SK (2004) Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction. Basic Clin Pharmacol Toxicol 94:184\u2013190","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2273_CR81","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, De Waal Malefyt R, Coffman RL, O\u2019garra, A. (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683\u2013765","journal-title":"Annu Rev Immunol"},{"key":"2273_CR82","doi-asserted-by":"crossref","unstructured":"Moris D, Spartalis M, Spartalis E, Karachaliou G-S, Karaolanis GI, Tsourouflis G, Tsilimigras DI, Tzatzaki E & Theocharis S (2017) &nbsp;The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox.\u00a0Ann\u00a0Transl\u00a0Med\u00a05","DOI":"10.21037\/atm.2017.06.27"},{"key":"2273_CR83","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.neubiorev.2016.07.018","volume":"74","author":"MO Murphy","year":"2017","unstructured":"Murphy MO, Cohn DM, Loria AS (2017) Developmental origins of cardiovascular disease: impact of early life stress in humans and rodents. Neurosci Biobehav Rev 74:453\u2013465","journal-title":"Neurosci Biobehav Rev"},{"key":"2273_CR84","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/aps.2016.142","volume":"38","author":"B-B Ning","year":"2017","unstructured":"Ning B-B, Zhang Y, Wu D-D, Cui J-G, Liu L, Wang P-W, Wang W-J, Zhu W-L, Chen Y, Zhang T (2017) Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice. Acta Pharmacol Sin 38:331\u2013341","journal-title":"Acta Pharmacol Sin"},{"key":"2273_CR85","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2<227::AID-JNR8>3.0.CO;2-E","volume":"57","author":"A Nitta","year":"1999","unstructured":"Nitta A, Ohmiya M, Sometani A, Itoh M, Nomoto H, Furukawa Y, Furukawa S (1999) Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone. J Neurosci Res 57:227\u2013235","journal-title":"J Neurosci Res"},{"key":"2273_CR86","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1080\/13880209.2019.1702704","volume":"58","author":"A Nouri","year":"2020","unstructured":"Nouri A, Hashemzadeh F, Soltani A, Saghaei E, Amini-Khoei H (2020) Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress. Pharm Biol 58:64\u201371","journal-title":"Pharm Biol"},{"key":"2273_CR87","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1161\/ATVBAHA.112.248930","volume":"32","author":"S Okada","year":"2012","unstructured":"Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y (2012) Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system\u2013mediated pathway. Arterioscler Thromb Vasc Biol 32:1902\u20131909","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2273_CR88","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00213-010-2010-9","volume":"214","author":"SM O\u2019mahony","year":"2011","unstructured":"O\u2019mahony SM, Hyland NP, Dinan TG, Cryan JF (2011) Maternal separation as a model of brain\u2013gut axis dysfunction. Psychopharmacology 214:71\u201388","journal-title":"Psychopharmacology"},{"key":"2273_CR89","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/S0006-2952(03)00425-8","volume":"66","author":"\u0160 Ozgov\u00e1","year":"2003","unstructured":"Ozgov\u00e1 \u0160, He\u0159m\u00e1nek J, GUT, I. (2003) Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-, Fe-ascorbate-and Fe-microsomal systems. Biochem Pharmacol 66:1127\u20131137","journal-title":"Biochem Pharmacol"},{"key":"2273_CR90","unstructured":"Ozougwu JC (2016) The role of reactive oxygen species and antioxidants in oxidative stress. Int J Res 1"},{"key":"2273_CR91","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","volume":"31","author":"CM Pariante","year":"2008","unstructured":"Pariante CM, Lightman SL (2008) The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31:464\u2013468","journal-title":"Trends Neurosci"},{"key":"2273_CR92","doi-asserted-by":"publisher","unstructured":"Park SU, Uddin R, Xu H, Kim YK, Lee SY (2008) Biotechnological applications for rosmarinic acid production in plant. Afr J Biotechnol 7.\u00a0https:\/\/doi.org\/10.4314\/AJB.V7I25.59707","DOI":"10.4314\/AJB.V7I25.59707"},{"key":"2273_CR93","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/pcn.12609","volume":"72","author":"SW Park","year":"2018","unstructured":"Park SW, Seo MK, Lee JG, Hien LT, Kim YH (2018) Effects of maternal separation and antidepressant drug on epigenetic regulation of the brain-derived neurotrophic factor exon I promoter in the adult rat hippocampus. Psychiatry Clin Neurosci 72:255\u2013265","journal-title":"Psychiatry Clin Neurosci"},{"issue":"10","key":"2273_CR94","first-page":"1","volume":"2013","author":"C Parrish","year":"2017","unstructured":"Parrish C, Surkan P, Martins S, Gattaz F, Andrade L, Viana M (2017) Childhood adversity and adult onset of hypertension and heart disease in S\u00e3o Paulo. Brazil Centers Dis Control Prev 2013(10):1\u20135","journal-title":"Brazil Centers Dis Control Prev"},{"key":"2273_CR95","doi-asserted-by":"publisher","first-page":"S58","DOI":"10.1016\/j.amjcard.2008.02.010","volume":"101","author":"FJ Pashkow","year":"2008","unstructured":"Pashkow FJ, Watumull DG, Campbell CL (2008) Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Am J Cardiol 101:S58\u2013S68","journal-title":"Am J Cardiol"},{"key":"2273_CR96","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ejphar.2010.06.065","volume":"644","author":"V Patel","year":"2010","unstructured":"Patel V, Upaganlawar A, Zalawadia R, Balaraman R (2010) Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: a biochemical, electrocardiographic and histoarchitectural evaluation. Eur J Pharmacol 644:160\u2013168","journal-title":"Eur J Pharmacol"},{"key":"2273_CR97","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.3390\/plants10081648","volume":"10","author":"T Pattananandecha","year":"2021","unstructured":"Pattananandecha T, Apichai S, Julsrigival J, Ungsurungsie M, Samuhasaneetoo S, Chulasiri P, Kwankhao P, Pitiporn S, Ogata F, Kawasaki N (2021) Antioxidant activity and anti-photoaging effects on UVA-irradiated human fibroblasts of rosmarinic acid enriched extract prepared from Thunbergia laurifolia leaves. Plants 10:1648","journal-title":"Plants"},{"key":"2273_CR98","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ajem.2006.07.013","volume":"25","author":"WF Peacock","year":"2007","unstructured":"Peacock WF, Hollander JE, Smalling RW, Bresler MJ (2007) Reperfusion strategies in the emergency treatment of ST-segment elevation myocardial infarction. Am J Emerg Med 25:353\u2013366","journal-title":"Am J Emerg Med"},{"key":"2273_CR99","doi-asserted-by":"publisher","first-page":"e011866","DOI":"10.1161\/JAHA.118.011866","volume":"8","author":"P Pimple","year":"2019","unstructured":"Pimple P, Lima BB, Hammadah M, Wilmot K, Ramadan R, Levantsevych O, Sullivan S, Kim JH, Kaseer B, Shah AJ (2019) Psychological distress and subsequent cardiovascular events in individuals with coronary artery disease. J Am Heart Assoc 8:e011866","journal-title":"J Am Heart Assoc"},{"key":"2273_CR100","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","volume":"47","author":"RD Porsolt","year":"1978","unstructured":"Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379\u2013391","journal-title":"Eur J Pharmacol"},{"key":"2273_CR101","first-page":"219","volume":"2","author":"K Rahman","year":"2007","unstructured":"Rahman K (2007) Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging 2:219","journal-title":"Clin Interv Aging"},{"issue":"9","key":"2273_CR102","first-page":"1","volume":"3","author":"M Raish","year":"2019","unstructured":"Raish M, Ahmad A, Ansari MA, Alkharfy KM, Ahad A, Khan A, Ali N, Ganaie MA, Hamidaddin MAA (2019) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats. Biotech 3(9):1\u201311","journal-title":"Biotech"},{"key":"2273_CR103","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbr.2012.11.044","volume":"242","author":"GZ R\u00e9us","year":"2013","unstructured":"R\u00e9us GZ, Dos Santos MAB, Abelaira HM, Ribeiro KF, Petronilho F, Vuolo F, Colpo GD, Pfaffenseller B, Kapczinski F, Dal-Pizzol F (2013) Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats. Behav Brain Res 242:40\u201346","journal-title":"Behav Brain Res"},{"key":"2273_CR104","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/dmrr.2732","volume":"32","author":"GZ Reus","year":"2016","unstructured":"Reus GZ, Dos Santos MAB, Abelaira HM, Titus SE, Carlessi AS, Matias BI, Bruchchen L, Florentino D, Vieira A, Petronilho F (2016) Antioxidant treatment ameliorates experimental diabetes-induced depressive-like behaviour and reduces oxidative stress in brain and pancreas. Diabetes Metab Res Rev 32:278\u2013288","journal-title":"Diabetes Metab Res Rev"},{"key":"2273_CR105","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.biopsych.2003.12.011","volume":"55","author":"M Roceri","year":"2004","unstructured":"Roceri M, Cirulli F, Pessina C, Peretto P, Racagni G, Riva MA (2004) Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions. Biol Psychiat 55:708\u2013714","journal-title":"Biol Psychiat"},{"key":"2273_CR106","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/bcpt.12335","volume":"116","author":"J Rocha","year":"2015","unstructured":"Rocha J, Eduardo-Figueira M, Barateiro A, Fernandes A, Brites D, Bronze R, Duarte CM, Serra AT, Pinto R, Freitas M (2015) Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. Basic Clin Pharmacol Toxicol 116:398\u2013413","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2273_CR107","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1161\/CIRCRESAHA.113.300268","volume":"113","author":"VL Roger","year":"2013","unstructured":"Roger VL (2013) Epidemiology of heart failure. Circ Res 113:646\u2013659","journal-title":"Circ Res"},{"key":"2273_CR108","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0166-4328(00)00364-8","volume":"120","author":"A Russo-Neustadt","year":"2001","unstructured":"Russo-Neustadt A, Ha T, Ramirez R, Kesslak JP (2001) Physical activity\u2013antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav Brain Res 120:87\u201395","journal-title":"Behav Brain Res"},{"key":"2273_CR109","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.brainres.2009.08.006","volume":"1295","author":"V Ryu","year":"2009","unstructured":"Ryu V, Yoo SB, Kang D-W, Lee J-H, Jahng JW (2009) Post-weaning isolation promotes food intake and body weight gain in rats that experienced neonatal maternal separation. Brain Res 1295:127\u2013134","journal-title":"Brain Res"},{"key":"2273_CR110","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbr.2005.12.001","volume":"169","author":"JCB S\u00e1enz","year":"2006","unstructured":"S\u00e1enz JCB, Villagra OR, Tr\u00edas JF (2006) Factor analysis of forced swimming test, sucrose preference test and open field test on enriched, social and isolated reared rats. Behav Brain Res 169:57\u201365","journal-title":"Behav Brain Res"},{"key":"2273_CR111","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11010-014-2092-5","volume":"394","author":"BD Sahu","year":"2014","unstructured":"Sahu BD, Putcha UK, Kuncha M, Rachamalla SS, Sistla R (2014) Carnosic acid promotes myocardial antioxidant response and prevents isoproterenol-induced myocardial oxidative stress and apoptosis in mice. Mol Cell Biochem 394:163\u2013176","journal-title":"Mol Cell Biochem"},{"key":"2273_CR112","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1017\/S0954579401003029","volume":"13","author":"MM Sanchez","year":"2001","unstructured":"Sanchez MM, Ladd CO, Plotsky PM (2001) Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models. Dev Psychopathol 13:419\u2013449","journal-title":"Dev Psychopathol"},{"key":"2273_CR113","doi-asserted-by":"publisher","first-page":"101337","DOI":"10.1016\/j.jddst.2019.101337","volume":"54","author":"V Sharma","year":"2019","unstructured":"Sharma V, Dewangan HK, Maurya L, Vats K, Verma H (2019) Rational design and in-vivo estimation of Ivabradine Hydrochloride loaded nanoparticles for management of stable angina. J Drug\u00a0Deliv\u00a0Sci\u00a0Technol\u00a054:101337","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"2273_CR114","doi-asserted-by":"publisher","first-page":"114164","DOI":"10.1016\/j.jep.2021.114164","volume":"275","author":"F Shen","year":"2021","unstructured":"Shen F, Song Z, Xie P, Li L, Wang B, Peng D, Zhu G (2021) Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage. J Ethnopharmacol 275:114164","journal-title":"J Ethnopharmacol"},{"key":"2273_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2017.08.019","volume":"1674","author":"N Shivavedi","year":"2017","unstructured":"Shivavedi N, Kumar M, Tej GNVC, Nayak PK (2017) Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. Brain Res 1674:1\u20139","journal-title":"Brain Res"},{"key":"2273_CR116","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0006-8993(95)01289-3","volume":"710","author":"JA Siuciak","year":"1996","unstructured":"Siuciak JA, Boylan C, Fritsche M, Altar CA, Lindsay RM (1996) BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res 710:11\u201320","journal-title":"Brain Res"},{"key":"2273_CR117","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/00006842-200011000-00007","volume":"62","author":"JJ Strik","year":"2000","unstructured":"Strik JJ, Honig A, Lousberg R, Lousberg AH, Cheriex EC, Tuynman-Qua HG, Kuijpers PM, Wellens H, Van Praag H (2000) Efficacy and safety of fluoxetine in the treatment of patients with major depression after first myocardial infarction: findings from a double-blind, placebo-controlled trial. Psychosom Med 62:783\u2013789","journal-title":"Psychosom Med"},{"key":"2273_CR118","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1042\/CS20080042","volume":"116","author":"C Stumpf","year":"2009","unstructured":"Stumpf C, Petzi S, Seybold K, Wasmeier G, Arnold M, Raaz D, Yilmaz A, Daniel WG, Garlichs CD (2009) Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction. Clin Sci 116:45\u201352","journal-title":"Clin Sci"},{"key":"2273_CR119","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1037\/0033-2909.131.2.260","volume":"131","author":"J Suls","year":"2005","unstructured":"Suls J, Bunde J (2005) Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions. Psychol Bull 131:260","journal-title":"Psychol Bull"},{"key":"2273_CR120","doi-asserted-by":"publisher","unstructured":"Su L-J, Zhang J-H, Gomez H, Murugan R, Hong X, Xu D, Jiang F, Peng Z-Y (2019) Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxidative Med Cell Longev.\u00a0https:\/\/doi.org\/10.1155\/2019\/5080843","DOI":"10.1155\/2019\/5080843"},{"key":"2273_CR121","first-page":"22063","volume":"8","author":"S-J Sun","year":"2015","unstructured":"Sun S-J, Wu X-P, Song H-L, Li G-Q (2015) Baicalin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation, oxidative stress and P38MAPK pathway in rat. Int J Clin Exp Med 8:22063","journal-title":"Int J Clin Exp Med"},{"key":"2273_CR122","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1007\/s00330-009-1385-7","volume":"19","author":"Z Szucs-Farkas","year":"2009","unstructured":"Szucs-Farkas Z, Strautz T, Patak MA, Kurmann L, Vock P, Schindera ST (2009) Is body weight the most appropriate criterion to select patients eligible for low-dose pulmonary CT angiography? Analysis of objective and subjective image quality at 80 kVp in 100 patients. Eur Radiol 19:1914\u20131922","journal-title":"Eur Radiol"},{"key":"2273_CR123","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0033-0620(86)90027-7","volume":"28","author":"JA Thompson","year":"1986","unstructured":"Thompson JA, Hess ML (1986) The oxygen free radical system: a fundamental mechanism in the production of myocardial necrosis. Prog Cardiovasc Dis 28:449\u2013462","journal-title":"Prog Cardiovasc Dis"},{"key":"2273_CR124","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","volume":"72","author":"K Thygesen","year":"2018","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD, Infarction, E. G. O. B. O. T. J. E. S. O. C. A. C. O. C. A. H. A. W. H. F. T. F. F. T. U. D. O. M (2018) Fourth universal definition of myocardial infarction (2018). J Am Coll Cardiol 72:2231\u20132264","journal-title":"J Am Coll Cardiol"},{"key":"2273_CR125","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0014-4800(80)90006-4","volume":"33","author":"GL Todd","year":"1980","unstructured":"Todd GL, Cullan GE, Cullan GM (1980) Isoproterenol-induced myocardial necrosis and membrane permeability alterations in the isolated perfused rabbit heart. Exp Mol Pathol 33:43\u201354","journal-title":"Exp Mol Pathol"},{"key":"2273_CR126","doi-asserted-by":"publisher","first-page":"110","DOI":"10.5455\/msm.2019.31.110-114","volume":"31","author":"AS Trajanovska","year":"2019","unstructured":"Trajanovska AS, Kostov J, Perevska Z (2019) Depression in survivors of acute myocardial infarction. Materia Socio-Medica 31:110","journal-title":"Materia Socio-Medica"},{"key":"2273_CR127","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3109\/10253890.2011.639414","volume":"15","author":"M Trombini","year":"2012","unstructured":"Trombini M, Hulshof H, Graiani G, Carnevali L, Meerlo P, Quaini F, Sgoifo A (2012) Early maternal separation has mild effects on cardiac autonomic balance and heart structure in adult male rats. Stress 15:457\u2013470","journal-title":"Stress"},{"key":"2273_CR128","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1093\/eurheartj\/ehy913","volume":"41","author":"V Vaccarino","year":"2020","unstructured":"Vaccarino V, Badimon L, Bremner JD, Cenko E, Cubedo J, Dorobantu M, Duncker DJ, Koller A, Manfrini O, Milicic D (2020) Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. Eur Heart J 41:1687\u20131696","journal-title":"Eur Heart J"},{"key":"2273_CR129","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1016\/j.jnutbio.2013.07.004","volume":"24","author":"LM Varela","year":"2013","unstructured":"Varela LM, Ortega-Gomez A, Lopez S, Abia R, Muriana FJ, Bermudez B (2013) The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein\/apoB48 receptor axis in human monocyte\/macrophage cells. J Nutr Biochem 24:2031\u20132039","journal-title":"J Nutr Biochem"},{"key":"2273_CR130","doi-asserted-by":"publisher","unstructured":"Verma H, Shivavedi N, Tej GNVC, Kumar M, Nayak PK (2022) Prophylactic administration of rosmarinic acid ameliorates depression-associated cardiac abnormalities in Wistar rats: Evidence of serotonergic, oxidative, and inflammatory pathways. J Biochem Mol Toxicol. https:\/\/doi.org\/10.1002\/jbt.23160","DOI":"10.1002\/jbt.23160"},{"key":"2273_CR131","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/S1734-1140(13)71505-6","volume":"65","author":"J Vetulani","year":"2013","unstructured":"Vetulani J (2013) Early maternal separation: a rodent model of depression and a prevailing human condition. Pharmacol Rep 65:1451\u20131461","journal-title":"Pharmacol Rep"},{"key":"2273_CR132","doi-asserted-by":"publisher","first-page":"e58488","DOI":"10.1371\/journal.pone.0058488","volume":"8","author":"JL Voorhees","year":"2013","unstructured":"Voorhees JL, Tarr AJ, Wohleb ES, Godbout JP, Mo X, Sheridan JF, Eubank TD, Marsh CB (2013) Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10. PLoS ONE 8:e58488","journal-title":"PLoS ONE"},{"key":"2273_CR133","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s00380-014-0607-3","volume":"31","author":"C Wan","year":"2016","unstructured":"Wan C, Chen Y, Yin P, Han D, Xu X, He S, Liu M, Hou X, Liu F, Xu J (2016) Transport stress induces apoptosis in rat myocardial tissue via activation of the mitogen-activated protein kinase signaling pathways. Heart Vessels 31:212\u2013221","journal-title":"Heart Vessels"},{"key":"2273_CR134","doi-asserted-by":"publisher","unstructured":"Wigger DC, Gr\u00f6ger N, Lesse A, Krause S, Merz T, G\u00fcndel H, Braun K, Mccook O. Radermacher P, Bock J (2020) Maternal separation induces long-term alterations in the cardiac oxytocin receptor and cystathionine \u03b3-lyase expression in mice. Oxidative Med Cell Longev.\u00a0https:\/\/doi.org\/10.1155\/2020\/4309605","DOI":"10.1155\/2020\/4309605"},{"key":"2273_CR135","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s12603-017-0985-1","volume":"22","author":"M Wleklik","year":"2018","unstructured":"Wleklik M, Uchmanowicz I, Jankowska-Pola\u0144ska B, Andreae C, Regulska-Ilow B (2018) The role of nutritional status in elderly patients with heart failure. J Nutr Health Aging 22:581\u2013588","journal-title":"J Nutr Health Aging"},{"key":"2273_CR136","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-01922-1","volume":"17","author":"RJ Worthen","year":"2020","unstructured":"Worthen RJ, Garzon Zighelboim SS, Torres Jaramillo CS, Beurel E (2020) Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice. J Neuroinflammation 17:1\u201316","journal-title":"J Neuroinflammation"},{"key":"2273_CR137","first-page":"1253","volume":"17","author":"BJ Yao","year":"2018","unstructured":"Yao BJ, He XQ, Lin YH, Dai WJ (2018) Cardioprotective effects of anisodamine against myocardial ischemia\/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis. Mol Med Rep 17:1253\u20131260","journal-title":"Mol Med Rep"},{"key":"2273_CR138","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbr.2019.01.008","volume":"362","author":"Y Ye","year":"2019","unstructured":"Ye Y, Yao S, Wang R, Fang Z, Zhong K, Nie L, Zhang Q (2019) PI3K\/Akt\/NF-\u03baB signaling pathway regulates behaviors in adolescent female rats following with neonatal maternal deprivation and chronic mild stress. Behav Brain Res 362:199\u2013207","journal-title":"Behav Brain Res"},{"key":"2273_CR139","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.psyneuen.2012.08.013","volume":"38","author":"SB Yoo","year":"2013","unstructured":"Yoo SB, Kim B-T, Kim JY, Ryu V, Kang D-W, Lee J-H, Jahng JW (2013) Adolescence fluoxetine increases serotonergic activity in the raphe-hippocampus axis and improves depression-like behaviors in female rats that experienced neonatal maternal separation. Psychoneuroendocrinology 38:777\u2013788","journal-title":"Psychoneuroendocrinology"},{"key":"2273_CR140","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1161\/CIRCRESAHA.107.148940","volume":"101","author":"Y Yu","year":"2007","unstructured":"Yu Y, Zhang Z-H, Wei S-G, Chu Y, Weiss RM, Heistad DD, Felder RB (2007) Central gene transfer of interleukin-10 reduces hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction. Circ Res 101:304\u2013312","journal-title":"Circ Res"},{"key":"2273_CR141","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1161\/01.CIR.102.3.344","volume":"102","author":"M Zaugg","year":"2000","unstructured":"Zaugg M, Xu W, Lucchinetti E, Shafiq SA, Jamali NZ, Siddiqui M (2000) \u03b2-Adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes. Circulation 102:344\u2013350","journal-title":"Circulation"},{"key":"2273_CR142","doi-asserted-by":"crossref","unstructured":"Zeldetz V, Natanel D, Boyko M, Zlotnik A, Shiyntum HN, Grinshpun J, Frank D, KUTS R, Brotfain E & Peiser J (2018)&nbsp;A new method for inducing a depression-like behavior in rats. JoVE (Journal of Visualized Experiments)\u00a0e57137","DOI":"10.3791\/57137"},{"key":"2273_CR143","doi-asserted-by":"publisher","first-page":"e69934","DOI":"10.1371\/journal.pone.0069934","volume":"8","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Zhu X, Bai M, Zhang L, Xue L, Yi J (2013) Maternal deprivation enhances behavioral vulnerability to stress associated with miR-504 expression in nucleus accumbens of rats. PLoS ONE 8:e69934","journal-title":"PLoS ONE"},{"key":"2273_CR144","doi-asserted-by":"publisher","first-page":"172953","DOI":"10.1016\/j.pbb.2020.172953","volume":"196","author":"L Zhou","year":"2020","unstructured":"Zhou L, Wu Z, Wang G, Xiao L, Wang H, Sun L, Xie Y (2020) Long-term maternal separation potentiates depressive-like behaviours and neuroinflammation in adult male C57\/BL6J mice. Pharmacol Biochem Behav 196:172953","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02273-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-022-02273-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02273-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T03:30:28Z","timestamp":1663039828000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-022-02273-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":144,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["2273"],"URL":"https:\/\/doi.org\/10.1007\/s00210-022-02273-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,25]]},"assertion":[{"value":"4 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human participants were not involved in any studies in this manuscript. All work had done with the approval from the Central Animal Ethical Committee of Banaras Hindu University, India, and conducted with care using the guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animal (CPCSEA), government of India.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have read and approved the final manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Immunoblot data"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}