{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:15:26Z","timestamp":1793261726926,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s00210-022-02295-3","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T11:02:58Z","timestamp":1663585378000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats"],"prefix":"10.1007","volume":"396","author":[{"given":"Seyed Sajad Hossieni","family":"Geshnigani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Mahdavinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Kalantar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layasadat","family":"Khorsandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-3074","authenticated-orcid":false,"given":"Hadi","family":"Kalantar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"2295_CR1","first-page":"1","volume":"2017","author":"MM Abdel-Daim","year":"2017","unstructured":"Abdel-Daim MM, Khalifa HA, Abushouk AI, Dkhil MA, Al-Quraishy SA (2017) Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury: a biochemical and histopathological study in mice. Oxidative Med Cell Longev 2017:1\u201310","journal-title":"Oxidative Med Cell Longev"},{"issue":"1","key":"2295_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1177\/0960327116689716","volume":"37","author":"R Abdelrahman","year":"2018","unstructured":"Abdelrahman R (2018) Protective effect of apocynin against gentamicin-induced nephrotoxicity in rats. Hum Exp Toxicol 37(1):27\u201337","journal-title":"Hum Exp Toxicol"},{"issue":"6","key":"2295_CR3","doi-asserted-by":"publisher","first-page":"996","DOI":"10.3109\/0886022X.2016.1165120","volume":"38","author":"M Adil","year":"2016","unstructured":"Adil M, Kandhare AD, Dalvi G, Ghosh P, Venkata S, Raygude KS, Bodhankar SL (2016) Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Ren Fail 38(6):996\u20131006","journal-title":"Ren Fail"},{"issue":"4","key":"2295_CR4","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1742-7843.2011.00728.x","volume":"109","author":"BH Ali","year":"2011","unstructured":"Ali BH, Al Za\u2019abi M, Blunden G, Nemmar A, (2011) Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research. Basic Clin Pharmacol Toxicol 109(4):225\u2013232","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"3","key":"2295_CR5","doi-asserted-by":"publisher","first-page":"e0122417","DOI":"10.1371\/journal.pone.0122417","volume":"10","author":"HH Arab","year":"2015","unstructured":"Arab HH, Salama SA, Omar HA, Arafa E-SA, Maghrabi IA (2015) Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions. PLoS ONE 10(3):e0122417","journal-title":"PLoS ONE"},{"issue":"6","key":"2295_CR6","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S1043-6618(03)00227-5","volume":"48","author":"A Ate\u015f\u015fahin","year":"2003","unstructured":"Ate\u015f\u015fahin A, Karahan I, Yilmaz S, \u00c7eriba\u015fi A, Princci I (2003) The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats. Pharmacol Res 48(6):637\u2013642","journal-title":"Pharmacol Res"},{"issue":"4","key":"2295_CR7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1177\/1470320312474853","volume":"15","author":"EH Bae","year":"2014","unstructured":"Bae EH, Kim IJ, Joo SY, Kim EY, Choi JS, Kim CS, Ma SK, Lee J, Kim SW (2014) Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats. J Renin-Angiotensin-Aldosterone Syst 15(4):348\u2013361","journal-title":"J Renin-Angiotensin-Aldosterone Syst"},{"issue":"3","key":"2295_CR8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.phrs.2010.04.004","volume":"62","author":"P Balakumar","year":"2010","unstructured":"Balakumar P, Rohilla A, Thangathirupathi A (2010) Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it? Pharmacol Res 62(3):179\u2013186","journal-title":"Pharmacol Res"},{"key":"2295_CR9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.etap.2017.06.026","volume":"54","author":"E Bami","year":"2017","unstructured":"Bami E, Ozakp\u0131nar OB, Ozdemir-Kumral ZN, K\u00f6roglu K, Ercan F, Cirakli Z, Sekerler T, Izzettin FV, Sancar M, Okuyan B (2017) Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats. Environ Toxicol Pharmacol 54:105\u2013111","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1\u20132","key":"2295_CR10","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1\u20132):248\u2013254","journal-title":"Anal Biochem"},{"key":"2295_CR11","doi-asserted-by":"crossref","unstructured":"Buege JA, Aust SD (1978) [30] Microsomal lipid peroxidation. In: Methods in enzymology, vol 52. Elsevier, pp 302\u2013310","DOI":"10.1016\/S0076-6879(78)52032-6"},{"issue":"7","key":"2295_CR12","doi-asserted-by":"publisher","first-page":"e12836","DOI":"10.1111\/jfbc.12836","volume":"43","author":"L Cao","year":"2019","unstructured":"Cao L, Zhi D, Han J, Kumar Sah S, Xie Y (2019) Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: involvement of antioxidative, anti-inflammatory and antiapoptotic pathway. J Food Biochem 43(7):e12836","journal-title":"J Food Biochem"},{"issue":"7","key":"2295_CR13","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.phymed.2013.02.007","volume":"20","author":"BC Chan","year":"2013","unstructured":"Chan BC, Ip M, Gong H, Lui S, See RH, Jolivalt C, Fung K, Leung P, Reiner NE, Lau CB (2013) Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220\/pUL5054 and inhibition of MRSA pyruvate kinase. Phytomedicine 20(7):611\u2013614","journal-title":"Phytomedicine"},{"issue":"2","key":"2295_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.niox.2010.12.001","volume":"24","author":"JS Christo","year":"2011","unstructured":"Christo JS, Rodrigues AM, Mouro MG, Cenedeze MA, de Jesus SM, Schor N, Higa EMS (2011) Nitric oxide (NO) is associated with gentamicin (GENTA) nephrotoxicity and the renal function recovery after suspension of GENTA treatment in rats. Nitric Oxide 24(2):77\u201383","journal-title":"Nitric Oxide"},{"key":"2295_CR15","unstructured":"Derakhshanfar A, Bidadkosh A, Kazeminia S (2007) Vitamin E protection against gentamicin-induced nephrotoxicity in rats: a biochemical and histopathologic study"},{"issue":"4","key":"2295_CR16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1080\/07315724.2019.1649218","volume":"39","author":"C Edeogu","year":"2020","unstructured":"Edeogu C, Kalu ME, Famurewa AC, Asogwa NT, Onyeji GN, Ikpemo KO (2020) Nephroprotective effect of Moringa oleifera seed oil on gentamicin-induced nephrotoxicity in rats: biochemical evaluation of antioxidant, anti-inflammatory, and antiapoptotic pathways. J Am Coll Nutr 39(4):307\u2013315","journal-title":"J Am Coll Nutr"},{"issue":"34","key":"2295_CR17","doi-asserted-by":"publisher","first-page":"35151","DOI":"10.1007\/s11356-019-06660-3","volume":"26","author":"AE Elhelaly","year":"2019","unstructured":"Elhelaly AE, AlBasher G, Alfarraj S, Almeer R, Bahbah EI, Fouda MM, Bung\u0103u SG, Aleya L, Abdel-Daim MM (2019) Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environ Sci Pollut Res 26(34):35151\u201335162","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"2295_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"2295_CR19","doi-asserted-by":"crossref","unstructured":"Erse\u00e7kin V, Mert H, \u0130rak K, Yildirim S, Mert N (2020) Nephroprotective effect of ferulic acid on gentamicin-induced nephrotoxicity in female rats. Drug Chem Toxicol 1\u20137","DOI":"10.1080\/01480545.2020.1759620"},{"issue":"5","key":"2295_CR20","first-page":"548","volume":"18","author":"R Ghaznavi","year":"2005","unstructured":"Ghaznavi R, Faghihi M, Kadkhodaee M, Shams S, Khastar H (2005) Effects of nitric oxide on gentamicin toxicity in isolated perfused rat kidneys. J Nephrol 18(5):548","journal-title":"J Nephrol"},{"issue":"2","key":"2295_CR21","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1124\/jpet.103.062216","volume":"309","author":"O Handa","year":"2004","unstructured":"Handa O, Naito Y, Takagi T, Shimozawa M, Kokura S, Yoshida N, Matsui H, Cepinskas G, Kvietys PR, Yoshikawa T (2004) Tumor necrosis factor-\u03b1-induced cytokine-induced neutrophil chemoattractant-1 (CINC-1) production by rat gastric epithelial cells: role of reactive oxygen species and nuclear factor-\u03baB. J Pharmacol Exp Ther 309(2):670\u2013676","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"2295_CR22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.15171\/jrip.2018.18","volume":"7","author":"A Hasanvand","year":"2018","unstructured":"Hasanvand A, Kharazmkia A, Mir S, Khorramabadi RM, Darabi S (2018) Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects. J Renal Inj Prev 7(2):73\u201377","journal-title":"J Renal Inj Prev"},{"key":"2295_CR23","unstructured":"Peake M, Whiting M (2006) Measurement of serum creatinine \u2013 current status and future goals. Clin Biochem Rev 27(4):173\u2013184"},{"issue":"1","key":"2295_CR24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S2095-4964(14)60001-7","volume":"12","author":"D Jain","year":"2014","unstructured":"Jain D, Bansal MK, Dalvi R, Upganlawar A, Somani R (2014) Protective effect of diosmin against diabetic neuropathy in experimental rats. J Integr Med 12(1):35\u201341","journal-title":"J Integr Med"},{"key":"2295_CR25","doi-asserted-by":"crossref","unstructured":"Kalantar H, Sabetkasaei M, Shahriari A, Haj Molla Hoseini M, Mansouri S, Kalantar M, Kalantari A, Khazaei Poul Y, Labibi F, Moini-Zanjani T (2016a) The effect of rapamycin on oxidative stress in MCF-7 and MDA MB-231 human breast cancer cell lines. Jundishapur J Nat Pharm Prod 11(3):e38177","DOI":"10.17795\/jjnpp-38177"},{"key":"2295_CR26","doi-asserted-by":"crossref","unstructured":"Kalantar M, Houshmand G, Kalantar H, Asadi M, Goudarzi M (2016b) Protective effect of hydroalcoholic extract of Lavandula officinalis L. on gentamicin induced nephrotoxicity in rats. J Babol Univ Med Sci 18(7):62\u201367","DOI":"10.15171\/PS.2017.04"},{"issue":"4","key":"2295_CR27","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.foodchem.2011.06.039","volume":"129","author":"SR Kang","year":"2011","unstructured":"Kang SR, Park KI, Park HS, Lee DH, Kim JA, Nagappan A, Kim EH, Lee WS, Shin SC, Park MK (2011) Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-\u03baB) and mitogen-activated protein kinase (MAPK) signalling pathways. Food Chem 129(4):1721\u20131728","journal-title":"Food Chem"},{"issue":"3","key":"2295_CR28","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.tox.2005.07.007","volume":"215","author":"\u0130 Karahan","year":"2005","unstructured":"Karahan \u0130, Ate\u015f\u015fahin A, Y\u0131lmaz S, \u00c7eriba\u015f\u0131 A, Sakin F (2005) Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology 215(3):198\u2013204","journal-title":"Toxicology"},{"issue":"1","key":"2295_CR29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1046\/j.0767-3981.2003.00211.x","volume":"18","author":"Y Karata\u015f","year":"2004","unstructured":"Karata\u015f Y, Se\u00e7ilmi\u015f MA, Karayaylal\u0131 \u0130, Doran F, B\u00fcy\u00fckaf\u015far K, \u015eingirik E, Sagl\u0131ker Y, Dikmen A (2004) Effect of tempol (4-hydroxy tempo) on gentamicin-induced nephrotoxicity in rats. Fundam Clin Pharmacol 18(1):79\u201383","journal-title":"Fundam Clin Pharmacol"},{"issue":"12","key":"2295_CR30","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1093\/ndt\/17.12.2122","volume":"17","author":"JD Kopple","year":"2002","unstructured":"Kopple JD, Ding H, Letoha A, Ivanyi B, Qing DPY, Dux L, Wang HY, Sonkodi S (2002) l-carnitine ameliorates gentamicin-induced renal injury in rats. Nephrol Dial Transplant 17(12):2122\u20132131","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"2295_CR31","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s003940050054","volume":"38","author":"S Kuntz","year":"1999","unstructured":"Kuntz S, Wenzel U, Daniel H (1999) Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr 38(3):133\u2013142","journal-title":"Eur J Nutr"},{"issue":"1","key":"2295_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/ki.2010.337","volume":"79","author":"JM Lopez-Novoa","year":"2011","unstructured":"Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ (2011) New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int 79(1):33\u201345","journal-title":"Kidney Int"},{"issue":"4","key":"2295_CR33","doi-asserted-by":"publisher","first-page":"151929","DOI":"10.1016\/j.imbio.2020.151929","volume":"225","author":"J Michalski","year":"2020","unstructured":"Michalski J, Deinzer A, Stich L, Zinser E, Steinkasserer A, Knippertz I (2020) Quercetin induces an immunoregulatory phenotype in maturing human dendritic cells. Immunobiology 225(4):151929","journal-title":"Immunobiology"},{"issue":"1","key":"2295_CR34","first-page":"17","volume":"72","author":"I Narita","year":"1995","unstructured":"Narita I, Border WA, Ketteler M, Noble NA (1995) Nitric oxide mediates immunologic injury to kidney mesangium in experimental glomerulonephritis. Lab Inv: a J Tech Methods Pathol 72(1):17\u201324","journal-title":"Lab Inv: a J Tech Methods Pathol"},{"issue":"3","key":"2295_CR35","doi-asserted-by":"publisher","first-page":"331","DOI":"10.5799\/ahinjs.01.2015.03.0545","volume":"6","author":"O \u00d6zcan","year":"2015","unstructured":"\u00d6zcan O, Erdal H, \u00c7ak\u0131rca G, Y\u00f6nden Z (2015) Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest 6(3):331\u2013336","journal-title":"J Clin Exp Invest"},{"issue":"1","key":"2295_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-43201-x","volume":"9","author":"AC Pushkaran","year":"2019","unstructured":"Pushkaran AC, Vinod V, Vanuopadath M, Nair SS, Nair SV, Vasudevan AK, Biswas R, Mohan CG (2019) Combination of repurposed drug diosmin with amoxicillin-clavulanic acid causes synergistic inhibition of mycobacterial growth. Sci Rep 9(1):1\u201314","journal-title":"Sci Rep"},{"issue":"1\u20133","key":"2295_CR37","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ejphar.2013.08.031","volume":"718","author":"SS Queenthy","year":"2013","unstructured":"Queenthy SS, John B (2013) Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol 718(1\u20133):213\u2013218","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"2295_CR38","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10787-012-0122-z","volume":"20","author":"KS Raygude","year":"2012","unstructured":"Raygude KS, Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL (2012) Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology 20(6):331\u2013341","journal-title":"Inflammopharmacology"},{"issue":"3\u20134","key":"2295_CR39","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1159\/000436975","volume":"96","author":"S Samarghandian","year":"2015","unstructured":"Samarghandian S, Azimi-Nezhad M, Mehrad-Majd H, Mirhafez SR (2015) Thymoquinone ameliorates acute renal failure in gentamicin-treated adult male rats. Pharmacology 96(3\u20134):112\u2013117","journal-title":"Pharmacology"},{"issue":"7","key":"2295_CR40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.5567\/pharmacologia.2015.273.281","volume":"6","author":"A Sarkar","year":"2015","unstructured":"Sarkar A, Sengupta A, Mukhrjee A, Guru A, Patil A, Kandhare AD, Bodhankar SL (2015) Antiulcer potential of morin in acetic acid-induced gastric ulcer via modulation of endogenous biomarkers in laboratory animals. Pharmacologia 6(7):273\u2013281","journal-title":"Pharmacologia"},{"key":"2295_CR41","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ejphar.2014.04.026","volume":"736","author":"O Senthamizhselvan","year":"2014","unstructured":"Senthamizhselvan O, Manivannan J, Silambarasan T, Raja B (2014) Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia\/reperfusion. Eur J Pharmacol 736:131\u2013137","journal-title":"Eur J Pharmacol"},{"key":"2295_CR42","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.biopha.2018.09.127","volume":"108","author":"S Shabani","year":"2018","unstructured":"Shabani S, Mirshekar MA (2018) Diosmin is neuroprotective in a rat model of scopolamine-induced cognitive impairment. Biomed Pharmacother 108:1376\u20131383","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2295_CR43","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1177\/0960327117694075","volume":"37","author":"A Shalkami","year":"2018","unstructured":"Shalkami A, Hassan M, Bakr A (2018) Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis. Hum Exp Toxicol 37(1):78\u201386","journal-title":"Hum Exp Toxicol"},{"issue":"1","key":"2295_CR44","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.cbi.2011.10.003","volume":"195","author":"S Srinivasan","year":"2012","unstructured":"Srinivasan S, Pari L (2012) Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Chem Biol Interact 195(1):43\u201351","journal-title":"Chem Biol Interact"},{"issue":"1","key":"2295_CR45","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1681\/ASN.V121114","volume":"12","author":"DP Sundin","year":"2001","unstructured":"Sundin DP, Sandoval R, Molitoris BA (2001) Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. J Am Soc Nephrol 12(1):114\u2013123","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"2295_CR46","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.toxlet.2013.04.004","volume":"220","author":"M Tahir","year":"2013","unstructured":"Tahir M, Rehman MU, Lateef A, Khan AQ, Khan R, Qamar W, O\u2019Hamiza O, Ali F, Hasan SK, Sultana S (2013a) Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicol Lett 220(3):205\u2013218","journal-title":"Toxicol Lett"},{"issue":"2","key":"2295_CR47","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.alcohol.2012.12.010","volume":"47","author":"M Tahir","year":"2013","unstructured":"Tahir M, Rehman MU, Lateef A, Khan R, Khan AQ, Qamar W, Ali F, O\u2019Hamiza O, Sultana S (2013b) Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-\u03b1 and NF-\u03baB activation. Alcohol 47(2):131\u2013139","journal-title":"Alcohol"},{"issue":"3","key":"2295_CR48","first-page":"922","volume":"252","author":"WR Tracey","year":"1990","unstructured":"Tracey WR, Linden J, Peach MJ, Johns RA (1990) Comparison of spectrophotometric and biological assays for nitric oxide (NO) and endothelium-derived relaxing factor (EDRF): nonspecificity of the diazotization reaction for NO and failure to detect EDRF. J Pharmacol Exp Ther 252(3):922\u2013928","journal-title":"J Pharmacol Exp Ther"},{"key":"2295_CR49","doi-asserted-by":"crossref","unstructured":"Randall S, Edson MD, Christine L (1999) The aminoglycosides. Mayo Clin Proc 74(5):519\u2013528","DOI":"10.1016\/S0025-6196(11)65134-3"},{"issue":"4","key":"2295_CR50","first-page":"28","volume":"12","author":"M Ural","year":"2004","unstructured":"Ural M, \u00d6zg\u00fcner M, \u015eenal D, S\u00fct\u00e7\u00fc R, Deliba\u015f N (2004) Effects of Vitamin C, Vitamin E and verapamil on cyclosporin induced nephrotoxicity in rats: a light microscobic study. Med J S\u00fcleyman Demirel Univ Fac Med 12(4):28\u201335","journal-title":"Med J S\u00fcleyman Demirel Univ Fac Med"},{"issue":"1","key":"2295_CR51","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","volume":"39","author":"M Valko","year":"2007","unstructured":"Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44\u201384","journal-title":"Int J Biochem Cell Biol"},{"key":"2295_CR52","first-page":"55","volume":"1","author":"A Yas\u0131m","year":"2011","unstructured":"Yas\u0131m A, \u00d6zba\u011f D, K\u0131l\u0131n\u00e7 M, \u00c7\u0131ral\u0131k H, Toru \u0130 (2011) The effect of diosmin-hesperidin combination treatment on the lipid profile and oxidativeantioxidative system in high-cholesterol diet-fed rats. T\u00fcrk G\u00f6\u011f\u00fcs Kalp Damar Cerrahisi Dergisi 1:55\u201361","journal-title":"T\u00fcrk G\u00f6\u011f\u00fcs Kalp Damar Cerrahisi Dergisi"},{"issue":"5","key":"2295_CR53","doi-asserted-by":"publisher","first-page":"152007","DOI":"10.1016\/j.imbio.2020.152007","volume":"225","author":"B Zhu","year":"2020","unstructured":"Zhu B, Wu G, Wang C, Xiao Y, Jin J, Wang K, Jiang Y, Sun Y, Ben D, Xia Z (2020) Soluble cluster of differentiation 74 regulates lung inflammation through the nuclear factor-\u03baB signaling pathway. Immunobiology 225(5):152007","journal-title":"Immunobiology"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02295-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-022-02295-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02295-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T07:04:27Z","timestamp":1671779067000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-022-02295-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["2295"],"URL":"https:\/\/doi.org\/10.1007\/s00210-022-02295-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,19]]},"assertion":[{"value":"11 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were done following the principles for the care and use of laboratory animals in research and confirmed by the Ethics Committee of Ahvaz Jundishapur University of Medical Sciences. (Ethics code: IR.AJUMS.ABHC.REC.1397.062). The study is reported in accordance with ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consented to the publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}