{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:37:08Z","timestamp":1774352228977,"version":"3.50.1"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Deanship of Research at Jordan University of Science and Technology","award":["369-2021"],"award-info":[{"award-number":["369-2021"]}]},{"name":"Deanship of Research at Jordan University of Science and Technology","award":["369-2021"],"award-info":[{"award-number":["369-2021"]}]},{"name":"Deanship of Research at Jordan University of Science and Technology","award":["369-2021"],"award-info":[{"award-number":["369-2021"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00210-022-02319-y","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T10:08:47Z","timestamp":1667642927000},"page":"337-351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The protective effect of rivaroxaban with or without aspirin on inflammation, oxidative stress, and platelet reactivity in isoproterenol-induced cardiac injury in rats"],"prefix":"10.1007","volume":"396","author":[{"given":"Nour N.","family":"Abedalqader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer M.","family":"Rababa\u2019h","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mera","family":"Ababneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"issue":"5","key":"2319_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.119.014941","volume":"9","author":"A Abbate","year":"2020","unstructured":"Abbate A, Trankle CR, Buckley LF, Lipinski MJ, Appleton D, Kadariya D, Canada JM, Carbone S, Roberts CS, Abouzaki N, Melchior R, Christopher S, Turlington J, Mueller G, Garnett J, Thomas C, Markley R, Wohlford GF, Puckett L, Van Tassell BW (2020) Interleukin-1 blockade inhibits the acute inflammatory response in patients with ST-segment-elevation myocardial infarction. J Am Heart Assoc 9(5):1\u20139. https:\/\/doi.org\/10.1161\/JAHA.119.014941","journal-title":"J Am Heart Assoc"},{"issue":"10","key":"2319_CR2","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1002\/ptr.6152","volume":"32","author":"P Allawadhi","year":"2018","unstructured":"Allawadhi P, Khurana A, Sayed N, Kumari P, Godugu C (2018) Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention. Phytother Res 32(10):1908\u20131932. https:\/\/doi.org\/10.1002\/ptr.6152","journal-title":"Phytother Res"},{"issue":"3","key":"2319_CR3","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.37506\/ijfmt.v15i3.15628","volume":"15","author":"BA Alyavi","year":"2021","unstructured":"Alyavi BA, Uzokov JK, Mukhitdinova O (2021) Antiplatelet therapy in coronary artery disease. Indian J Forensic Med Toxicol 15(3):2111\u20132115. https:\/\/doi.org\/10.37506\/ijfmt.v15i3.15628","journal-title":"Indian J Forensic Med Toxicol"},{"issue":"2","key":"2319_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1476-5381.1985.tb08920.x","volume":"86","author":"J Ambler","year":"1985","unstructured":"Ambler J, Butler KD, Ku EC, Maguire ED, Smith JR, Wallis RB (1985) CGS 12970: a novel, long acting thromboxane synthetase inhibitor. Br J Pharmacol 86(2):497\u2013504. https:\/\/doi.org\/10.1111\/j.1476-5381.1985.tb08920.x","journal-title":"Br J Pharmacol"},{"issue":"11","key":"2319_CR5","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1161\/ATVBAHA.110.213280","volume":"30","author":"S Antoniak","year":"2010","unstructured":"Antoniak S, Rojas M, Spring D, Bullard TA, Verrier ED, Blaxall BC, Mackman N, Pawlinski R (2010) Protease-activated receptor 2 deficiency reduces cardiac ischemia\/reperfusion injury. Arterioscler Thromb Vasc Biol 30(11):2136\u20132142. https:\/\/doi.org\/10.1161\/ATVBAHA.110.213280","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"2319_CR6","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/joim.12296","volume":"276","author":"L Badimon","year":"2014","unstructured":"Badimon L, Vilahur G (2014) Thrombosis formation on atherosclerotic lesions and plaque rupture. J Intern Med 276(6):618\u2013632. https:\/\/doi.org\/10.1111\/joim.12296","journal-title":"J Intern Med"},{"issue":"1","key":"2319_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/2048872612441582","volume":"1","author":"L Badimon","year":"2012","unstructured":"Badimon L, Padr\u00f3 T, Vilahur G (2012) Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease. Eur Heart J Acute Cardiovasc Care 1(1):60\u201374. https:\/\/doi.org\/10.1177\/2048872612441582","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2319_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2017.09.013","volume":"122","author":"C Bakogiannis","year":"2019","unstructured":"Bakogiannis C, Sachse M, Stamatelopoulos K, Stellos K (2019) Platelet-derived chemokines in inflammation and atherosclerosis. Cytokine 122:1\u201310. https:\/\/doi.org\/10.1016\/j.cyto.2017.09.013","journal-title":"Cytokine"},{"issue":"4","key":"2319_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s40292-019-00325-5","volume":"26","author":"M Barbarawi","year":"2019","unstructured":"Barbarawi M, Kheiri B, Zayed Y, Gakhal I, Al-Abdouh A, Barbarawi O, Rashdan L, Rizk F, Bachuwa G, Alkotob ML (2019) Aspirin efficacy in primary prevention: a meta-analysis of randomized controlled trials. High Blood Press Cardiovasc Prev 26(4):283\u2013291. https:\/\/doi.org\/10.1007\/s40292-019-00325-5","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"4","key":"2319_CR10","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/ph3041016","volume":"3","author":"G Barisione","year":"2010","unstructured":"Barisione G, Baroffio M, Crimi E, Brusasco V (2010) Beta-Adrenergic Agonists. Pharmaceuticals 3(4):1016\u20131044. https:\/\/doi.org\/10.3390\/ph3041016","journal-title":"Pharmaceuticals"},{"issue":"7","key":"2319_CR11","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1080\/17512433.2018.1495559","volume":"11","author":"V Barrios","year":"2018","unstructured":"Barrios V, Almendro-Delia M, Facila L, Garcia-Moll X, Mazon P, Camafort M, Mar\u00eda Cepeda J, Mediavilla Garcia JD, Pose Reino A, Suarez Fernandez C (2018) Rivaroxaban: searching the integral vascular protection. Expert Rev Clin Pharmacol 11(7):719\u2013728. https:\/\/doi.org\/10.1080\/17512433.2018.1495559","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"12","key":"2319_CR12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1161\/CIR.0000000000000558","volume":"137","author":"EJ Benjamin","year":"2018","unstructured":"Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, De Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jim\u00e9nez MC, Jordan LC, Judd SE, Lackland D, Muntner P (2018) Heart disease and stroke statistics - 2018 update: a report from the American Heart Association. Circulation 137(12):67\u2013492. https:\/\/doi.org\/10.1161\/CIR.0000000000000558","journal-title":"Circulation"},{"issue":"12","key":"2319_CR13","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","volume":"114","author":"JF Bentzon","year":"2014","unstructured":"Bentzon JF, Otsuka F, Virmani R, Falk E (2014) Mechanisms of plaque formation and rupture. Circ Res 114(12):1852\u20131866. https:\/\/doi.org\/10.1161\/CIRCRESAHA.114.302721","journal-title":"Circ Res"},{"issue":"2","key":"2319_CR14","first-page":"95","volume":"27","author":"GS Bodor","year":"2016","unstructured":"Bodor GS (2016) Biochemical markers of myocardial damage. J Int Fed Clin Chem Lab Med 27(2):95\u2013111","journal-title":"J Int Fed Clin Chem Lab Med"},{"issue":"3","key":"2319_CR15","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/cvr\/cvp066","volume":"82","author":"JI Borissoff","year":"2009","unstructured":"Borissoff JI, Spronk HM, Heeneman S, Ten Cate H (2009) Is thrombin a key player in the \u201ccoagulation-atherogenesis\u201d maze? Cardiovasc Res 82(3):392\u2013403. https:\/\/doi.org\/10.1093\/cvr\/cvp066","journal-title":"Cardiovasc Res"},{"issue":"8","key":"2319_CR16","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1161\/CIRCULATIONAHA.109.907121","volume":"122","author":"JI Borissoff","year":"2010","unstructured":"Borissoff JI, Heeneman S, Kilin\u00e7 E, Ka\u0161\u0161\u00e1k P, Van Oerle R, Winckers K, Govers-Riemslag JW, Hamuly\u00e1k K, Hackeng TM, Daemen MJ, Ten Cate H, Spronk HM (2010) Early atherosclerosis exhibits an enhanced procoagulant state. Circulation 122(8):821\u2013830. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.907121","journal-title":"Circulation"},{"issue":"2","key":"2319_CR17","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1161\/01.ATV.0000151279.35780.2d","volume":"25","author":"G Busch","year":"2005","unstructured":"Busch G, Seitz I, Steppich B, Hess S, Eckl R, Sch\u00f6mig A, Ott I (2005) Coagulation factor Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes implications in acute myocardial infarction. Atheroscler Thromb Vasc Biol 25(2):461\u2013466. https:\/\/doi.org\/10.1161\/01.ATV.0000151279.35780.2d","journal-title":"Atheroscler Thromb Vasc Biol"},{"key":"2319_CR18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bcp.2019.02.016","volume":"163","author":"V Cammisotto","year":"2019","unstructured":"Cammisotto V, Carnevale R, Nocella C, Stefanini L, Bartimoccia S, Coluccia A, Silvestri R, Pignatelli P, Pastori D, Violi F (2019) Nox2-mediated platelet activation by glycoprotein (GP) VI: effect of rivaroxaban alone and in combination with aspirin. Biochem Pharmacol 163:111\u2013118. https:\/\/doi.org\/10.1016\/j.bcp.2019.02.016","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"2319_CR19","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/s41569-018-0049-1","volume":"15","author":"D Capodanno","year":"2018","unstructured":"Capodanno D, Mehran R, Valgimigli M, Baber U, Windecker S, Vranckx P, Dangas G, Rollini F, Kimura T, Collet JP, Gibson CM, Steg PG, Lopes RD, Gwon HC, Storey RF, Franchi F, Bhatt DL, Serruys PW, Angiolillo DJ (2018) Aspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention. Nat Rev Cardiol 15(8):480\u2013496","journal-title":"Nat Rev Cardiol"},{"issue":"2\u20133","key":"2319_CR20","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/10715762.2020.1735632","volume":"54","author":"A Carretero","year":"2020","unstructured":"Carretero A, Gomez-Cabrera MC, Rios-Navarro C, Salvador-Pascual A, Bodi V, Vi\u00f1a J (2020) Early reductive stress and late onset overexpression of antioxidant enzymes in experimental myocardial infarction. Free Radical Res 54(2\u20133):173\u2013184. https:\/\/doi.org\/10.1080\/10715762.2020.1735632","journal-title":"Free Radical Res"},{"issue":"3","key":"2319_CR21","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1161\/CIRCRESAHA.118.313141","volume":"124","author":"M Coppens","year":"2019","unstructured":"Coppens M, Weitz JI, Eikelboom JW (2019) Synergy of dual pathway inhibition in chronic cardiovascular disease: lessons from the COMPASS trial. Circ Res 124(3):416\u2013425. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313141","journal-title":"Circ Res"},{"key":"2319_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2013.00324","volume":"4","author":"G Corbi","year":"2013","unstructured":"Corbi G, Conti V, Russomanno G, Longobardi G, Furgi G, Filippelli A, Ferrara N (2013) Adrenergic signaling and oxidative stress: a role for sirtuins? Front Physiol 4:1\u201314. https:\/\/doi.org\/10.3389\/fphys.2013.00324","journal-title":"Front Physiol"},{"issue":"12","key":"2319_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0240669","volume":"15","author":"A Daci","year":"2020","unstructured":"Daci A, Da Dalt L, Alaj R, Shurdhiqi S, Neziri B, Ferizi R, Norata GD, Krasniqi S (2020) Rivaroxaban improves vascular response in LPS-induced acute inflammation in experimental models. PLoS One 15(12):1\u201316. https:\/\/doi.org\/10.1371\/journal.pone.0240669","journal-title":"PLoS One"},{"issue":"1","key":"2319_CR24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.13005\/bpj\/1634","volume":"12","author":"K Dayana","year":"2019","unstructured":"Dayana K, Manasa MR (2019) Evaluation of the effect of ceftriaxone on lipid peroxidation and antioxidant levels in mice. Biomed Pharmacol J 12(1):245\u2013250. https:\/\/doi.org\/10.13005\/bpj\/1634","journal-title":"Biomed Pharmacol J"},{"issue":"3","key":"2319_CR25","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.thromres.2011.11.001","volume":"129","author":"E De Candia","year":"2012","unstructured":"De Candia E (2012) Mechanisms of platelet activation by thrombin: a short history. Thromb Res 129(3):250\u2013256. https:\/\/doi.org\/10.1016\/j.thromres.2011.11.001","journal-title":"Thromb Res"},{"issue":"1-2","key":"2319_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0049-3848(79)90064-1","volume":"15","author":"E Dejana","year":"1979","unstructured":"Dejana E, Callioni A, Quintana A (1979) Bleeding time in laboratory animals. II - a comparison of different assay conditions in rats. Thromb Res 15(1\u20132):191\u2013197","journal-title":"Thromb Res"},{"issue":"5","key":"2319_CR27","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1472-8206.2010.00836.x","volume":"24","author":"NS Dhalla","year":"2010","unstructured":"Dhalla NS, Adameova A, Kaur M (2010) Role of catecholamine oxidation in sudden cardiac death. Fundam Clin Pharmacol 24(5):539\u2013546. https:\/\/doi.org\/10.1111\/j.1472-8206.2010.00836.x","journal-title":"Fundam Clin Pharmacol"},{"issue":"14","key":"2319_CR28","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1056\/nejmoa1709118","volume":"377","author":"JW Eikelboom","year":"2017","unstructured":"Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O, Diaz R, Alings M, Lonn EM, Anand SS, Widimsky P, Hori M, Avezum A, Piegas LS, Branch KRH, Probstfield J, Bhatt DL, Zhu J, Liang Y, Yusuf S (2017) Rivaroxaban with or without aspirin in stable cardiovascular disease. N Engl J Med 377(14):1319\u20131330. https:\/\/doi.org\/10.1056\/nejmoa1709118","journal-title":"N Engl J Med"},{"issue":"6","key":"2319_CR29","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1515\/cclm-2013-0936","volume":"52","author":"T Eller","year":"2014","unstructured":"Eller T, Busse J, Dittrich M, Flieder T, Alban S, Knabbe C, Birschmann I (2014) Dabigatran, rivaroxaban, apixaban, argatroban and fondaparinux and their effects on coagulation POC and platelet function tests. Clin Chem Lab Med 52(6):835\u2013844. https:\/\/doi.org\/10.1515\/cclm-2013-0936","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"2319_CR30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/jcmm.15937","volume":"25","author":"E Forte","year":"2021","unstructured":"Forte E, Panahi M, Baxan N, Ng FS, Boyle JJ, Branca J, Bedard O, Muneer Hasham MG, Benson L, Harding SE, Rosenthal N, Sattler S (2021) Type 2 MI induced by a single high dose of isoproterenol in C57BL\/6 J mice triggers a persistent adaptive immune response against the heart. J Cell Mol Med 25(1):229\u2013243. https:\/\/doi.org\/10.1111\/jcmm.15937","journal-title":"J Cell Mol Med"},{"issue":"6","key":"2319_CR31","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1177\/1074248419861437","volume":"24","author":"E Fuentes","year":"2019","unstructured":"Fuentes E, Moore-Carrasco R, de Andrade Paes AM, Trostchansky A (2019) Role of platelet activation and oxidative stress in the evolution of myocardial infarction. J Cardiovasc Pharmacol Ther 24(6):509\u2013520. https:\/\/doi.org\/10.1177\/1074248419861437","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"6","key":"2319_CR32","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s00395-011-0196-6","volume":"106","author":"JB Garlie","year":"2011","unstructured":"Garlie JB, Hamid T, Gu Y, Ismahil MA, Chandrasekar B, Prabhu SD (2011) Tumor necrosis factor receptor 2 signaling limits \u03b2-adrenergic receptor-mediated cardiac hypertrophy in vivo. Basic Res Cardiol 106(6):1193\u20131205. https:\/\/doi.org\/10.1007\/s00395-011-0196-6","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"2319_CR33","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/ijlh.12528","volume":"38","author":"R Gosselin","year":"2016","unstructured":"Gosselin R, Grant RP, Adcock DM (2016) Comparison of the effect of the anti-Xa direct oral anticoagulants apixaban, edoxaban, and rivaroxaban on coagulation assays. Int J Lab Hematol 38(5):505\u2013513. https:\/\/doi.org\/10.1111\/ijlh.12528","journal-title":"Int J Lab Hematol"},{"issue":"11","key":"2319_CR34","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1177\/0091270007302952","volume":"47","author":"J Graff","year":"2007","unstructured":"Graff J, Von Hentig N, Misselwitz F, Kubitza D, Becka M, Breddin HK, Harder S (2007) Effects of the oral, direct factor Xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity. J Clin Pharmacol 47(11):1398\u20131407. https:\/\/doi.org\/10.1177\/0091270007302952","journal-title":"J Clin Pharmacol"},{"issue":"7","key":"2319_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0232507","volume":"15","author":"MK Grant","year":"2020","unstructured":"Grant MK, Abdelgawad IY, Lewis CA, Seelig D, Zordoky BN (2020) Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction. PLoS One 15(7):1\u201319. https:\/\/doi.org\/10.1371\/journal.pone.0232507","journal-title":"PLoS One"},{"issue":"2","key":"2319_CR36","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.atherosclerosis.2015.03.023","volume":"242","author":"T Hara","year":"2015","unstructured":"Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Nishimoto S, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M (2015) Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice. Atherosclerosis 242(2):639\u2013646. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2015.03.023","journal-title":"Atherosclerosis"},{"issue":"19\u201320","key":"2319_CR37","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.lfs.2011.07.025","volume":"89","author":"P Harding","year":"2011","unstructured":"Harding P, Murray DB (2011) The contribution of prostaglandins versus prostacyclin in ventricular remodeling during heart failure. Life Sci 89(19\u201320):671\u2013676. https:\/\/doi.org\/10.1016\/j.lfs.2011.07.025","journal-title":"Life Sci"},{"issue":"8","key":"2319_CR38","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1089\/jmf.2012.2191","volume":"15","author":"A Hussain Shaik","year":"2012","unstructured":"Hussain Shaik A, Rasool SN, Kareem MA, Krushna GS, Akhtar PM, Devi KL (2012) Maslinic acid protects against isoproterenol-induced cardiotoxicity in albino Wistar rats. J Med Food 15(8):741\u2013746. https:\/\/doi.org\/10.1089\/jmf.2012.2191","journal-title":"J Med Food"},{"issue":"1","key":"2319_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2155-9600.1000335","volume":"5","author":"MA Hussein","year":"2015","unstructured":"Hussein MA (2015) Cardioprotective effects of astaxanthin against isoproterenol-induced cardiotoxicity in rats. J Nutr Food Sci 5(1):1\u20136. https:\/\/doi.org\/10.4172\/2155-9600.1000335","journal-title":"J Nutr Food Sci"},{"issue":"8","key":"2319_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.119.012195","volume":"8","author":"H Ichikawa","year":"2019","unstructured":"Ichikawa H, Shimada M, Narita M, Narita I, Kimura Y, Tanaka M, Osanai T, Okumura K, Tomita H (2019) Rivaroxaban, a direct factor Xa inhibitor, ameliorates hypertensive renal damage through inhibition of the inflammatory response mediated by protease-activated receptor pathway. J Am Heart Assoc 8(8):1\u201314. https:\/\/doi.org\/10.1161\/JAHA.119.012195","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"2319_CR41","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s12012-019-09551-8","volume":"20","author":"F Imam","year":"2020","unstructured":"Imam F, Al-Harbi NO, Khan MR, Qamar W, Alharbi M, Alshamrani AA, Alhamami HN, Alsaleh NB, Alharbi KS (2020) Protective effect of RIVA against sunitinib-induced cardiotoxicity by inhibiting oxidative stress-mediated inflammation: probable role of TGF-\u03b2 and Smad signaling. Cardiovasc Toxicol 20(3):281\u2013290. https:\/\/doi.org\/10.1007\/s12012-019-09551-8","journal-title":"Cardiovasc Toxicol"},{"issue":"24","key":"2319_CR42","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1161\/CIRCULATIONAHA.111.066787","volume":"125","author":"F Jaffr\u00e9","year":"2012","unstructured":"Jaffr\u00e9 F, Friedman AE, Hu Z, Mackman N, Blaxall BC (2012) \u03b2-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125(24):2993\u20133003. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.066787","journal-title":"Circulation"},{"issue":"7","key":"2319_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11892-019-1161-2","volume":"19","author":"R Jagannathan","year":"2019","unstructured":"Jagannathan R, Patel SA, Ali MK, Narayan KM (2019) Global updates on cardiovascular disease mortality trends and attribution of traditional risk factors. Curr Diab Rep 19(7):1\u201312. https:\/\/doi.org\/10.1007\/s11892-019-1161-2","journal-title":"Curr Diab Rep"},{"issue":"5","key":"2319_CR44","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1007\/s11033-018-4297-2","volume":"45","author":"PG Jain","year":"2018","unstructured":"Jain PG, Mahajan UB, Shinde SD, Surana SJ (2018) Cardioprotective role of FA against isoproterenol induced cardiac toxicity. Mol Biol Rep 45(5):1357\u20131365. https:\/\/doi.org\/10.1007\/s11033-018-4297-2","journal-title":"Mol Biol Rep"},{"issue":"3","key":"2319_CR45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.amjcard.2008.11.017","volume":"103","author":"LK Jennings","year":"2009","unstructured":"Jennings LK (2009) Role of platelets in atherothrombosis. Am J Cardiol 103(3):4\u201310. https:\/\/doi.org\/10.1016\/j.amjcard.2008.11.017","journal-title":"Am J Cardiol"},{"issue":"5","key":"2319_CR46","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1097\/FJC.0000000000000622","volume":"72","author":"YM Jia","year":"2018","unstructured":"Jia YM, Gu TT, Ji JZ, Tai T, Zhang MR (2018) Aspirin attenuates the bioactivation of and platelet response to Vicagrel in mice. J Cardiovasc Pharmacol 72(5):252\u2013258","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"2319_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.119.013470","volume":"9","author":"X Jiang","year":"2020","unstructured":"Jiang X, Liu X, Liu X, Wu X, Jose PA, Liu M, Yang Z (2020) Low-dose aspirin treatment attenuates male rat salt-sensitive hypertension via platelet cyclooxygenase 1 and complement cascade pathway. J Am Heart Assoc 9(1):1\u201319. https:\/\/doi.org\/10.1161\/JAHA.119.013470","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"2319_CR48","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1007\/s00380-017-0962-y","volume":"32","author":"H Katoh","year":"2017","unstructured":"Katoh H, Nozue T, Michishita I (2017) Anti-inflammatory effect of factor-Xa inhibitors in Japanese patients with atrial fibrillation. Heart Vessels 32(9):1130\u20131136. https:\/\/doi.org\/10.1007\/s00380-017-0962-y","journal-title":"Heart Vessels"},{"issue":"10","key":"2319_CR49","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1056\/NEJMoa0807646","volume":"123","author":"K Kobiyama","year":"2018","unstructured":"Kobiyama K, Ley K (2018) Atherosclerosis: a chronic inflammatory disease with an autoimmune component. Circ Res 123(10):1118\u20131120. https:\/\/doi.org\/10.1056\/NEJMoa0807646","journal-title":"Circ Res"},{"issue":"8","key":"2319_CR50","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1161\/STROKEAHA","volume":"45","author":"S Kono","year":"2014","unstructured":"Kono S, Yamashita T, Deguchi K, Omote Y, Yunoki T, Sato K, Kurata T, Hishikawa N, Abe K (2014) Rivaroxaban and apixaban reduce hemorrhagic transformation after thrombolysis by protection of neurovascular unit in rat. Stroke 45(8):2404\u20132410. https:\/\/doi.org\/10.1161\/STROKEAHA","journal-title":"Stroke"},{"key":"2319_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/1656450","volume":"2016","author":"GA Kurian","year":"2016","unstructured":"Kurian GA, Rajagopal R, Vedantham S, Rajesh M (2016) The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: revisited. Oxid Med Cell Longev 2016:1\u201314. https:\/\/doi.org\/10.1155\/2016\/1656450","journal-title":"Oxid Med Cell Longev"},{"issue":"10159","key":"2319_CR52","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","volume":"392","author":"HH Kyu","year":"2018","unstructured":"Kyu HH, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, Abdollahpour I, Abdulkader RS, Abebe M, Abebe Z, Abil OZ, Aboyans V, Abrham AR, Abu-Raddad LJ, Abu-Rmeileh NM, Murray CJL (2018) Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159):1859\u20131922. https:\/\/doi.org\/10.1016\/S0140-6736(18)32335-3","journal-title":"Lancet"},{"issue":"2","key":"2319_CR53","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s12012-012-9196-5","volume":"13","author":"G Lalitha","year":"2013","unstructured":"Lalitha G, Poornima P, Archanah A, Padma VV (2013) Protective effect of neferine against isoproterenol-induced cardiac toxicity. Cardiovasc Toxicol 13(2):168\u2013179. https:\/\/doi.org\/10.1007\/s12012-012-9196-5","journal-title":"Cardiovasc Toxicol"},{"issue":"2","key":"2319_CR54","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1097\/MEG.0000000000001030","volume":"30","author":"A Licata","year":"2018","unstructured":"Licata A, Puccia F, Lombardo V, Serruto A, Minissale MG, Morreale I, Giannitrapani L, Soresi M, Montalto G, Almasio PL (2018) Rivaroxaban-induced hepatotoxicity: review of the literature and report of new cases. Eur J Gastroenterol Hepatol 30(2):226\u2013232. https:\/\/doi.org\/10.1097\/MEG.0000000000001030","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"2319_CR55","doi-asserted-by":"publisher","first-page":"273","DOI":"10.5142\/jgr.2013.37.273","volume":"37","author":"KH Lim","year":"2013","unstructured":"Lim KH, Ko D, Kim JH (2013) Cardioprotective potential of Korean red ginseng extract on isoproterenol-induced cardiac injury in rats. J Ginseng Res 37(3):273\u2013282. https:\/\/doi.org\/10.5142\/jgr.2013.37.273","journal-title":"J Ginseng Res"},{"issue":"11","key":"2319_CR56","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.4314\/tjpr.v17i11.12","volume":"17","author":"J Liu","year":"2018","unstructured":"Liu J, Chen L, Lu H (2018) Cardioprotective effect of salvianolic acid B against isoproterenol-induced inflammation and histological changes in a cardiotoxicity rat model. Trop J Pharm Res 17(11):2189\u20132197. https:\/\/doi.org\/10.4314\/tjpr.v17i11.12","journal-title":"Trop J Pharm Res"},{"issue":"10","key":"2319_CR57","doi-asserted-by":"publisher","first-page":"915","DOI":"10.5551\/jat.48405","volume":"26","author":"J Liu","year":"2019","unstructured":"Liu J, Nishida M, Inui H, Chang J, Zhu Y, Kanno K, Matsuda H, Sairyo M, Okada T, Nakaoka H, Ohama T, Masuda D, Koseki M, Yamashita S, Sakata Y (2019) Rivaroxaban suppresses the progression of ischemic cardiomyopathy in a murine model of diet-induced myocardial infarction. J Atheroscler Thromb 26(10):915\u2013930. https:\/\/doi.org\/10.5551\/jat.48405","journal-title":"J Atheroscler Thromb"},{"issue":"1","key":"2319_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.blre.2020.100694","volume":"45","author":"R Lordan","year":"2021","unstructured":"Lordan R, Tsoupras A, Zabetakis I (2021) Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: potential role of antiplatelet agents. Blood Rev 45(1):1\u201318. https:\/\/doi.org\/10.1016\/j.blre.2020.100694","journal-title":"Blood Rev"},{"issue":"1","key":"2319_CR59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00281-011-0281-9","volume":"34","author":"L Ma","year":"2012","unstructured":"Ma L, Dorling A (2012) The roles of thrombin and protease-activated receptors in inflammation. Semin Immunopathol 34(1):63\u201372. https:\/\/doi.org\/10.1007\/s00281-011-0281-9","journal-title":"Semin Immunopathol"},{"issue":"1","key":"2319_CR60","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.thromres.2019.02.014","volume":"176","author":"J Mabley","year":"2019","unstructured":"Mabley J, Patel JP, Sayed A, Arya R, Scutt G (2019) Direct oral anticoagulant (DOAC)-mediated vasodilation: role of nitric oxide. Thromb Res 176(1):36\u201338. https:\/\/doi.org\/10.1016\/j.thromres.2019.02.014","journal-title":"Thromb Res"},{"issue":"7","key":"2319_CR61","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/labinvest.2015.49","volume":"95","author":"G Maity","year":"2015","unstructured":"Maity G, De A, Das A, Banerjee S, Sarkar S, Banerjee SK (2015) Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition. Lab Invest 95(7):702\u2013717. https:\/\/doi.org\/10.1038\/labinvest.2015.49","journal-title":"Lab Invest"},{"issue":"1","key":"2319_CR62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.17305\/BJBMS.2019.4320","volume":"20","author":"A Milutinovi\u0107","year":"2020","unstructured":"Milutinovi\u0107 A, \u0160uput D, Zorc-Pleskovi\u010d R (2020) Pathogenesis of atherosclerosis in the tunica intima, media, and adventitia of coronary arteries: an updated review. Bosnian J Basic Med Sci 20(1):21\u201330. https:\/\/doi.org\/10.17305\/BJBMS.2019.4320","journal-title":"Bosnian J Basic Med Sci"},{"issue":"11","key":"2319_CR63","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1016\/S0735-1097(17)35422-0","volume":"69","author":"R Mitsuishi","year":"2017","unstructured":"Mitsuishi R, Imano H, Kato R, Ijiri Y, Yamaguchi T, Yoshiyama M, Hayashi T (2017) Rivaroxaban attenuates cardiac remodeling due to intermittent hypoxia by suppressing the synergistic effects of PAR-1 and PAR-2. J Am Coll Cardiol 69(11):2033. https:\/\/doi.org\/10.1016\/S0735-1097(17)35422-0","journal-title":"J Am Coll Cardiol"},{"issue":"38","key":"2319_CR64","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","volume":"34","author":"G Montalescot","year":"2013","unstructured":"Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, Ferreira JR, Gersh BJ, Gitt AK, Hulot JS, Marx N, Opie LH, Pfisterer M, Prescott E, Ruschitzka F, Yildirir A (2013) 2013 ESC guidelines on the management of stable coronary artery disease. Eur Heart J 34(38):2949\u20133003. https:\/\/doi.org\/10.1093\/eurheartj\/eht296","journal-title":"Eur Heart J"},{"issue":"3","key":"2319_CR65","doi-asserted-by":"publisher","first-page":"141","DOI":"10.5099\/aj190300141","volume":"11","author":"SM Moursi","year":"2019","unstructured":"Moursi SM, Ashour WM, Elbelbesy RM (2019) Vaspin improves experimental isoproterenol-induced heart failure in rats. Am J Biomed Sci 11(3):141\u2013151. https:\/\/doi.org\/10.5099\/aj190300141","journal-title":"Am J Biomed Sci"},{"issue":"3","key":"2319_CR66","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/jpi.12213","volume":"58","author":"D Mukherjee","year":"2015","unstructured":"Mukherjee D, Ghosh AK, Dutta M, Mitra E, Mallick S, Saha B, Reiter RJ, Bandyopadhyay D (2015) Mechanisms of isoproterenol-induced cardiac mitochondrial damage: protective actions of melatonin. J Pineal Res 58(3):275\u2013290. https:\/\/doi.org\/10.1111\/jpi.12213","journal-title":"J Pineal Res"},{"issue":"2","key":"2319_CR67","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.119.315453","volume":"125","author":"PT Murphy","year":"2019","unstructured":"Murphy PT, Grace S, Glavey S, Quinn J (2019) Rivaroxaban may increase platelet activation in vivo via thromboxane A2. Circ Res 125(2):e9. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.315453","journal-title":"Circ Res"},{"issue":"2","key":"2319_CR68","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1182\/blood-2002-12-3882","volume":"102","author":"B Nieswandt","year":"2003","unstructured":"Nieswandt B, Watson SP (2003) Platelet-collagen interaction: is GPVI the central receptor? Blood 102(2):449\u2013461. https:\/\/doi.org\/10.1182\/blood-2002-12-3882","journal-title":"Blood"},{"issue":"4","key":"2319_CR69","doi-asserted-by":"publisher","first-page":"513","DOI":"10.5606\/tgkdc.dergisi.2019.18061","volume":"27","author":"E \u00d6zbudak","year":"2019","unstructured":"\u00d6zbudak E, Ceyla Eraldemir FC, Ar\u0131kan AA, \u015eahin D, K\u0131r HM, Kurt T, Faruk G\u00fcla\u015ft\u0131 \u00d6F, Yavuz \u015e (2019) An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: an experimental study. Turk J Thorac Cardiovasc Surg 27(4):513\u2013520. https:\/\/doi.org\/10.5606\/tgkdc.dergisi.2019.18061","journal-title":"Turk J Thorac Cardiovasc Surg"},{"issue":"8","key":"2319_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0135228","volume":"10","author":"JY Park","year":"2015","unstructured":"Park JY, Lee S-H, Shin M-J, Hwang GS (2015) Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. PLoS One 10(8):1\u201315. https:\/\/doi.org\/10.1371\/journal.pone.0135228","journal-title":"PLoS One"},{"key":"2319_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2019.01244","volume":"10","author":"C Patrono","year":"2019","unstructured":"Patrono C, Rocca B (2019) Measurement of thromboxane biosynthesis in health and disease. Front Pharmacol 10:1\u201311. https:\/\/doi.org\/10.3389\/fphar.2019.01244","journal-title":"Front Pharmacol"},{"issue":"20","key":"2319_CR72","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1161\/CIRCULATIONAHA.107.692764","volume":"116","author":"R Pawlinski","year":"2007","unstructured":"Pawlinski R, Tencati M, Hampton CR, Shishido T, Bullard TA, Casey LM, Andrade-Gordon P, Kotzsch M, Spring D, Luther T, Abe J, Pohlman TH, Verrier ED, Blaxall BC, Mackman N (2007) Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation 116(20):2298\u20132306. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.692764","journal-title":"Circulation"},{"issue":"1","key":"2319_CR73","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nrd3185","volume":"10","author":"E Perzborn","year":"2011","unstructured":"Perzborn E, Roehrig S, Straub A, Kubitza D, Misselwitz F (2011) The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor. Nat Rev Drug Discovery 10(1):61\u201375. https:\/\/doi.org\/10.1038\/nrd3185","journal-title":"Nat Rev Drug Discovery"},{"issue":"6","key":"2319_CR74","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1177\/1074248415578172","volume":"20","author":"E Perzborn","year":"2015","unstructured":"Perzborn E, Heitmeier S, Laux V (2015) Effects of rivaroxaban on platelet activation and platelet-coagulation pathway interaction: in vitro and in vivo studies. J Cardiovasc Pharmacol Ther 20(6):554\u2013562. https:\/\/doi.org\/10.1177\/1074248415578172","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"4","key":"2319_CR75","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/CIRCRESAHA.119.315099","volume":"126","author":"T Petzold","year":"2020","unstructured":"Petzold T, Thienel M, Dannenberg L, Mourikis P, Helten C, Ayhan A, M\u2019Pembele R, Achilles A, Trojavky K, Konsek D, Zhang Z, Regenauer R, Pircher J, Ehrlich A, L\u00fcsebrink E, Nicolai L, Stocker TJ, Brandl R, R\u00f6schenthaler F, Polzin A (2020) Rivaroxaban reduces arterial thrombosis by inhibition of FXa-driven platelet activation via protease activated receptor-1. Circ Res 126(4):486\u2013500. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.315099","journal-title":"Circ Res"},{"issue":"12","key":"2319_CR76","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.jacbts.2021.10.015","volume":"6","author":"JJ Posma","year":"2021","unstructured":"Posma JJ, Sluimer JC (2021) Pleiotropic, cellular effects of rivaroxaban on autophagy explain atheroprotective effects. J Am Coll Cardiol 6(12):981\u2013983. https:\/\/doi.org\/10.1016\/j.jacbts.2021.10.015","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2319_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40360-021-00510-0","volume":"22","author":"CP Pullaiah","year":"2021","unstructured":"Pullaiah CP, Nelson VK, Rayapu S, GV NK, Kedam T (2021) Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence. BMC Pharmacol Toxicol 22(1):1\u201311. https:\/\/doi.org\/10.1186\/s40360-021-00510-0","journal-title":"BMC Pharmacol Toxicol"},{"issue":"7","key":"2319_CR78","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s12012-021-09645-2","volume":"21","author":"AM Rababa\u2019h","year":"2021","unstructured":"Rababa\u2019h AM, Alzoubi MA (2021) Origanum majorana L. extract protects against isoproterenol-induced cardiotoxicity in rats. Cardiovasc Toxicol 21(7):543\u2013552. https:\/\/doi.org\/10.1007\/s12012-021-09645-2","journal-title":"Cardiovasc Toxicol"},{"issue":"1","key":"2319_CR79","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/1573403X14666180111145207","volume":"14","author":"AM Rababa\u2019h","year":"2018","unstructured":"Rababa\u2019h AM, Guillory AN, Mustafa R, Hijjawi T (2018) Oxidative stress and cardiac remodeling: an updated edge. Curr Cardiol Rev 14(1):53\u201359. https:\/\/doi.org\/10.2174\/1573403X14666180111145207","journal-title":"Curr Cardiol Rev"},{"issue":"2","key":"2319_CR80","doi-asserted-by":"publisher","first-page":"28","DOI":"10.12983\/ijsrk-2016-p0028-0032","volume":"4","author":"A Rafeeq","year":"2016","unstructured":"Rafeeq A, Najam R, Hussain SJ (2016) Aspirin associated liver toxicity \u2013 the optimal dose of aspirin in liver insufficiency. Int J Sci Res Knowl 4(2):28\u201332. https:\/\/doi.org\/10.12983\/ijsrk-2016-p0028-0032","journal-title":"Int J Sci Res Knowl"},{"issue":"4","key":"2319_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13205-019-1677-9","volume":"9","author":"M Raish","year":"2019","unstructured":"Raish M, Ahmad A, Ansari MA, Alkharfy KM, Ahad A, Khan A, Ali N, Ganaie MA, Hamidaddin MA (2019) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats. 3 Biotech 9(4):1\u201311","journal-title":"3 Biotech"},{"issue":"1","key":"2319_CR82","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nrd3615","volume":"11","author":"R Ramachandran","year":"2012","unstructured":"Ramachandran R, Noorbakhsh F, DeFea K, Hollenberg MD (2012) Targeting proteinase-activated receptors: therapeutic potential and challenges. Nat Rev Drug Discovery 11(1):69\u201386. https:\/\/doi.org\/10.1038\/nrd3615","journal-title":"Nat Rev Drug Discovery"},{"issue":"4","key":"2319_CR83","first-page":"297","volume":"38","author":"N Rathore","year":"1998","unstructured":"Rathore N, John S, Kale M, Bhatnagar D (1998) Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat tissues. Indian J Physiol Pharmacol 38(4):297\u2013303","journal-title":"Indian J Physiol Pharmacol"},{"issue":"1","key":"2319_CR84","doi-asserted-by":"publisher","first-page":"130","DOI":"10.21037\/cdt-20-859","volume":"11","author":"BM Rocha","year":"2021","unstructured":"Rocha BM, da Cunha GJ, Aguiar CM (2021) A narrative review of low-dose rivaroxaban in patients with atherothrombotic cardiovascular disease: vascular protection beyond anticoagulation. Cardiovasc Diagn Ther 11(1):130\u2013141. https:\/\/doi.org\/10.21037\/cdt-20-859","journal-title":"Cardiovasc Diagn Ther"},{"issue":"10159","key":"2319_CR85","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","volume":"392","author":"GA Roth","year":"2018","unstructured":"Roth GA, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, Abdollahpour I, Abdulkader RS, Abebe HT, Abebe M, Abebe Z, Abejie AN, Abera SF, Abil OZ, Abraha HN, Murray CJL (2018) Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159):1736\u20131788. https:\/\/doi.org\/10.1016\/S0140-6736(18)32203-7","journal-title":"Lancet"},{"key":"2319_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/478039","volume":"2015","author":"M Sagor","year":"2015","unstructured":"Sagor M, Taher A, Tabassum N, Potol M, Alam M (2015) Xanthine oxidase inhibitor, allopurinol, prevented oxidative stress, fibrosis, and myocardial damage in isoproterenol induced aged rats. Oxid Med Cell Longev 2015:1\u20139. https:\/\/doi.org\/10.1155\/2015\/478039","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"2319_CR87","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1055\/a-1001-2154","volume":"69","author":"F Samiei","year":"2019","unstructured":"Samiei F, Sajjadi H, Jamshidzadeh A, Seydi E, Pourahmad J (2019) Contrasting role of concentration in rivaroxaban induced toxicity and oxidative stress in isolated kidney mitochondria. Drug Res 69(10):523\u2013527. https:\/\/doi.org\/10.1055\/a-1001-2154","journal-title":"Drug Res"},{"issue":"2","key":"2319_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01480545.2021.1894707","volume":"44","author":"G Sangeethadevi","year":"2021","unstructured":"Sangeethadevi G, Jansy Isabella RAR, Saravanan G, Ponmurugan P, Chandrasekaran P, Sengottuvelu S, Vadivukkarasi S (2021) Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin-A in isoproterenol-induced myocardial infarction in rats. Drug Chem Toxicol 44(2):1\u201312. https:\/\/doi.org\/10.1080\/01480545.2021.1894707","journal-title":"Drug Chem Toxicol"},{"issue":"8","key":"2319_CR89","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1080\/17512433.2019.1637732","volume":"12","author":"M Sanmart\u00edn","year":"2019","unstructured":"Sanmart\u00edn M, Bellmunt S, Cos\u00edn-Sales J, Garc\u00eda-Moll X, Riera-Mestre A, Almendro-Delia M, Luis Hern\u00e1ndez J, Lozano F, Maz\u00f3n P, Suarez Fern\u00e1ndez C (2019) Role of rivaroxaban in the prevention of atherosclerotic events. Expert Rev Clin Pharmacol 12(8):771\u2013780. https:\/\/doi.org\/10.1080\/17512433.2019.1637732","journal-title":"Expert Rev Clin Pharmacol"},{"key":"2319_CR90","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2014.12.010","volume":"80","author":"F Santilli","year":"2015","unstructured":"Santilli F, Lapenna D, La Barba S, Dav\u00ec G (2015) Oxidative stress-related mechanisms affecting response to aspirin in diabetes mellitus. Free Radical Biol Med 80:101\u2013110. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.12.010","journal-title":"Free Radical Biol Med"},{"key":"2319_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/09603271211064532","volume":"41","author":"D Shackebaei","year":"2022","unstructured":"Shackebaei D, Hesari M, Ramezani-Aliakbari S, Hoseinkhani Z, Ramezani-Aliakbari F (2022) Gallic acid protects against isoproterenol-induced cardiotoxicity in rats. Hum Exp Toxicol 41:1\u201310. https:\/\/doi.org\/10.1177\/09603271211064532","journal-title":"Hum Exp Toxicol"},{"issue":"5","key":"2319_CR92","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1177\/1076029617725602","volume":"24","author":"S Shahzad","year":"2018","unstructured":"Shahzad S, Hasan A, Faizy AF, Mateen S, Fatima N, Moin S (2018) Elevated DNA damage, oxidative stress, and impaired response defense system inflicted in patients with myocardial infarction. Clin Appl Thromb Hemost 24(5):780\u2013789. https:\/\/doi.org\/10.1177\/1076029617725602","journal-title":"Clin Appl Thromb Hemost"},{"issue":"6","key":"2319_CR93","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1160\/TH16-10-0745","volume":"117","author":"C Sindet-Pedersen","year":"2017","unstructured":"Sindet-Pedersen C, Pallisgaard JL, Staerk L, Gerds TA, Fosb\u00f8l EL, Torp-Pedersen C, Gislason G, Olesen JB (2017) Comparative safety and effectiveness of rivaroxaban versus VKAs in patients with venous thromboembolism: a Danish nationwide registry-based study. Thromb Haemost 117(6):1182\u20131191. https:\/\/doi.org\/10.1160\/TH16-10-0745","journal-title":"Thromb Haemost"},{"issue":"8","key":"2319_CR94","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41573-021-00198-1","volume":"20","author":"O Soehnlein","year":"2021","unstructured":"Soehnlein O, Libby P (2021) Targeting inflammation in atherosclerosis \u2014 from experimental insights to the clinic. Nat Rev Drug Discovery 20(8):589\u2013610. https:\/\/doi.org\/10.1038\/s41573-021-00198-1","journal-title":"Nat Rev Drug Discovery"},{"issue":"2","key":"2319_CR95","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1476-5381.2010.00705.x","volume":"160","author":"UJ Soh","year":"2010","unstructured":"Soh UJ, Dores MR, Chen B, Trejo J (2010) Signal transduction by protease-activated receptors. Br J Pharmacol 160(2):191\u2013203. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00705.x","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2319_CR96","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jep.2012.02.017","volume":"141","author":"Q Song","year":"2012","unstructured":"Song Q, Wang S, Zhao W (2012) Total steroidal alkaloids from Veratrum patulum L. Inhibit platelet aggregation, thrombi formation and decrease bleeding time in rats. J Ethnopharmacol 141(1):183\u2013186. https:\/\/doi.org\/10.1016\/j.jep.2012.02.017","journal-title":"J Ethnopharmacol"},{"key":"2319_CR97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/3610285","volume":"2020","author":"L Song","year":"2020","unstructured":"Song L, Srilakshmi M, Wu Y, Saleem TS (2020) Sulforaphane attenuates isoproterenol-induced myocardial injury in mice. Biomed Res Int 2020:1\u20137. https:\/\/doi.org\/10.1155\/2020\/3610285","journal-title":"Biomed Res Int"},{"issue":"1","key":"2319_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-9560-2-12","volume":"2","author":"HM Spronk","year":"2004","unstructured":"Spronk HM, Van Der Voort D, Ten Cate H (2004) Blood coagulation and the risk of atherothrombosis: a complex relationship. Thromb J 2(1):1\u201310. https:\/\/doi.org\/10.1186\/1477-9560-2-12","journal-title":"Thromb J"},{"issue":"3","key":"2319_CR99","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/cvr\/cvt343","volume":"101","author":"HM Spronk","year":"2014","unstructured":"Spronk HM, De Jong AM, Crijns HJ, Schotten U, Van Gelder IC, Ten Cate H (2014) Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants. Cardiovasc Res 101(3):344\u2013351. https:\/\/doi.org\/10.1093\/cvr\/cvt343","journal-title":"Cardiovasc Res"},{"issue":"5","key":"2319_CR100","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1007\/s00580-019-02955-6","volume":"28","author":"K Swapna","year":"2019","unstructured":"Swapna K, Sathibabu Uddandrao VV, Parim B, Ravindarnaik R, Suresh P, Ponnusamy P, Balakrishnan S, Vadivukkarasi S, Harishankar N, Reddy KP, Nivedha PR, Saravanan G (2019) Effects of asiatic acid, an active constituent in Centella asiatica (L.): restorative perspectives of streptozotocin-nicotinamide induced changes on lipid profile and lipid metabolic enzymes in diabetic rats. Comp Clin Pathol 28(5):1321\u20131329. https:\/\/doi.org\/10.1007\/s00580-019-02955-6","journal-title":"Comp Clin Pathol"},{"issue":"21","key":"2319_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms222111644","volume":"22","author":"M Szczuko","year":"2021","unstructured":"Szczuko M, Kozio\u0142 I, Kotlega D, Brodowski J, Drozd A (2021) The role of thromboxane in the course and treatment of ischemic stroke: review. Int J Mol Sci 22(21):1\u201315. https:\/\/doi.org\/10.3390\/ijms222111644","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2319_CR102","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2217\/fca-2019-0091","volume":"16","author":"U Tantry","year":"2020","unstructured":"Tantry U, Cummings C, MacKrell P, Gonze M, Ulloa K, Bafford R, Rout A, Sukhi A, Gurbel P (2020) Synergistic influence of rivaroxaban on inflammation and coagulation biomarkers in patients with coronary artery disease and peripheral artery disease on aspirin therapy. Future Cardiol 16(2):69\u201375. https:\/\/doi.org\/10.2217\/fca-2019-0091","journal-title":"Future Cardiol"},{"key":"2319_CR103","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.phrs.2016.04.001","volume":"107","author":"E Tarantino","year":"2016","unstructured":"Tarantino E, Amadio P, Squellerio I, Porro B, Sandrini L, Turnu L, Cavalca V, Tremoli E, Barbieri SS (2016) Role of thromboxane-dependent platelet activation in venous thrombosis: aspirin effects in mouse model. Pharmacol Res 107:415\u2013425. https:\/\/doi.org\/10.1016\/j.phrs.2016.04.001","journal-title":"Pharmacol Res"},{"issue":"4","key":"2319_CR104","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/jcpt.12288","volume":"40","author":"KB Tellor","year":"2015","unstructured":"Tellor KB, Patel S, Armbruster AL, Daly MW (2015) Evaluation of the appropriateness of dosing, indication and safety of rivaroxaban in a community hospital. J Clin Pharm Ther 40(4):447\u2013451. https:\/\/doi.org\/10.1111\/jcpt.12288","journal-title":"J Clin Pharm Ther"},{"issue":"3","key":"2319_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cpcardiol.2020.100553","volume":"46","author":"A Ujjawal","year":"2021","unstructured":"Ujjawal A, Gupta M, Ghosh RK, Jain V, Bandyopadhyay D, Qamar A, Aronow WS, Deedwania P, Kapadia S, Lavie CJ (2021) Aspirin for primary prevention of coronary artery disease. Curr Probl Cardiol 46(3):1\u201318. https:\/\/doi.org\/10.1016\/j.cpcardiol.2020.100553","journal-title":"Curr Probl Cardiol"},{"issue":"5","key":"2319_CR106","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1159\/000431361","volume":"24","author":"OG Utku","year":"2015","unstructured":"Utku OG, Karatay EA, Erdal H, Arhan M, Onal IK, Ibis M, Ekinci O, Yilmaz Demirtas C, Unal S (2015) Rivaroxaban induces mucosal healing in a rat model of trinitrobenzene sulfonic acid-induced colitis. Med Princ Pract 24(5):470\u2013476. https:\/\/doi.org\/10.1159\/000431361","journal-title":"Med Princ Pract"},{"issue":"1","key":"2319_CR107","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s11033-018-04575-9","volume":"46","author":"VK Verma","year":"2019","unstructured":"Verma VK, Malik S, Narayanan SP, Mutneja E, Sahu AK, Bhatia J, Arya DS (2019) Role of MAPK\/NF-\u03baB pathway in cardioprotective effect of Morin in isoproterenol induced myocardial injury in rats. Mol Biol Rep 46(1):1139\u20131148. https:\/\/doi.org\/10.1007\/s11033-018-04575-9","journal-title":"Mol Biol Rep"},{"key":"2319_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2020.173524","volume":"885","author":"VP Viswanadha","year":"2020","unstructured":"Viswanadha VP, Dhivya V, Beeraka NM, Huang CY, Gavryushova LV, Minyaeva NN, Chubarev VN, Mikhaleva LM, Tarasov VV, Aliev G (2020) The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity. Eur J Pharmacol 885:1\u201311. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173524","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"2319_CR109","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1097\/MBC.0000000000000509","volume":"27","author":"H Wan","year":"2016","unstructured":"Wan H, Yang Y, Zhu J, Wu S, Zhou Z, Huang B, Wang J, Shao X, Zhang H (2016) An in-vitro evaluation of direct thrombin inhibitor and factor Xa inhibitor on tissue factor-induced thrombin generation and platelet aggregation: a comparison of dabigatran and rivaroxaban. Blood Coag Fibrinol 27(8):882\u2013885. https:\/\/doi.org\/10.1097\/MBC.0000000000000509","journal-title":"Blood Coag Fibrinol"},{"issue":"2","key":"2319_CR110","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","volume":"124","author":"D Wolf","year":"2019","unstructured":"Wolf D, Ley K (2019) Immunity and inflammation in atherosclerosis. Circ Res 124(2):315\u2013327. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313591","journal-title":"Circ Res"},{"key":"2319_CR111","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.biopha.2017.08.009","volume":"94","author":"ZW Wong","year":"2017","unstructured":"Wong ZW, Thanikachalam PV, Ramamurthy S (2017) Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: a review. Biomed Pharmacother 94:1145\u20131166. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.009","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2319_CR112","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/eurheartj\/ehx261","volume":"39","author":"H Xiao","year":"2018","unstructured":"Xiao H, Li H, Wang JJ, Zhang JS, Shen J, An XB, Zhang CC, Wu JM, Song Y, Wang XY, Yu HY, Deng XN, Li ZJ, Xu M, Lu ZZ, Du J, Gao W, Zhang AH, Feng Y, Zhang YY (2018) IL-18 cleavage triggers cardiac inflammation and fibrosis upon \u03b2-Adrenergic insult. Eur Heart J 39(1):60\u201369. https:\/\/doi.org\/10.1093\/eurheartj\/ehx261","journal-title":"Eur Heart J"},{"issue":"5","key":"2319_CR113","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s12012-020-09574-6","volume":"20","author":"Q Xie","year":"2020","unstructured":"Xie Q, Li S, Gao Y, Jin L, Dai C, Song J (2020) Ergosterol attenuates isoproterenol-induced myocardial cardiotoxicity. Cardiovasc Toxicol 20(5):500\u2013506. https:\/\/doi.org\/10.1007\/s12012-020-09574-6","journal-title":"Cardiovasc Toxicol"},{"issue":"2","key":"2319_CR114","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1177\/0192623307313010","volume":"36","author":"J Zhang","year":"2008","unstructured":"Zhang J, Knapton A, Lipshultz SE, Weaver JL, Herman EH (2008) Isoproterenol-induced cardiotoxicity in Sprague-Dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury. Toxicol Pathol 36(2):277\u2013288. https:\/\/doi.org\/10.1177\/0192623307313010","journal-title":"Toxicol Pathol"},{"issue":"2","key":"2319_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/1755-5922.12241","volume":"35","author":"R Zhou","year":"2017","unstructured":"Zhou R, Ma P, Xiong A, Xu Y, Wang Y, Xu Q (2017) Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway. Cardiovasc Ther 35(2):1\u20138. https:\/\/doi.org\/10.1111\/1755-5922.12241","journal-title":"Cardiovasc Ther"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02319-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-022-02319-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02319-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T10:08:01Z","timestamp":1673345281000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-022-02319-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,5]]},"references-count":115,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["2319"],"URL":"https:\/\/doi.org\/10.1007\/s00210-022-02319-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,5]]},"assertion":[{"value":"26 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental procedures were performed in congruency with the regulations of the Animal Care and Use Committee (ACUC; ACUC approval No. 412\u20132021) at Jordan University of Science and Technology and in accordance with the concepts of laboratory animal care and use as involved in the European Community Guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}