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The leaves and flowers of this plant have been used for centuries in traditional medicine to treat various ailments such as cough, cold, diarrhoea, and constipation. Google Scholar, PubMed, Scopus, and Web of Science were used to search for relevant material on the phytochemical profiling and pharmacologic activities of\n                    <jats:italic>Malva sylvestris<\/jats:italic>\n                    . The techniques used in phytochemical profiling and the pharmacologic activity of each compound were extracted from the included studies, including in vitro, in vivo, and clinical studies. The phytochemical analysis of\n                    <jats:italic>Malva sylvestris<\/jats:italic>\n                    revealed that the leaves and flowers are the most commonly used parts of the plant and contain various bioactive compounds such as flavonoids, mucilages, terpenoids, phenol derivatives, coumarins, sterols, tannins, saponins, and alkaloids. These phytochemicals are responsible for the many pharmacological activities of\n                    <jats:italic>Malva sylvestris,<\/jats:italic>\n                    such as anti-inflammatory, antimicrobial, hepatoprotective, laxative, antiproliferative and antioxidant properties. This review has presented an overview of the antinociceptive and anti-inflammatory activities and the cytotoxic effects of\n                    <jats:italic>Malva sylvestris<\/jats:italic>\n                    on different types of cancer cells. It has also summarised the work on developing copper oxide nanoparticles using\n                    <jats:italic>Malva sylvestris<\/jats:italic>\n                    leaf extract and its potential use in food and medicine. This review aims to highlight the traditional uses, phytochemistry, pharmacological activities, and safety of\n                    <jats:italic>Malva sylvestris<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1007\/s00210-022-02329-w","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T10:18:15Z","timestamp":1669285095000},"page":"421-440","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The phytochemical profiling, pharmacological activities, and safety of malva sylvestris: a review"],"prefix":"10.1007","volume":"396","author":[{"given":"Gaber El-Saber","family":"Batiha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephano Tambo","family":"Tene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Oluwafemi","family":"Teibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem M.","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyerinde Samson","family":"Oluwatoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titilade Kehinde Ayandeyi","family":"Teibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al-kuraishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali I.","family":"Al-Garbee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"2329_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cbi.2008.05.003","volume":"174","author":"T Ak","year":"2008","unstructured":"Ak T, G\u00fcl\u00e7in \u0130 (2008) Antioxidant and radical scavenging properties of curcumin. 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