{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:37:49Z","timestamp":1759963069330,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s00210-022-02366-5","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T09:04:43Z","timestamp":1671613483000},"page":"963-972","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of uterine contractility by guanine-based purines in non-pregnant rats"],"prefix":"10.1007","volume":"396","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-6529","authenticated-orcid":false,"given":"Maria Grazia","family":"Zizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5118-9347","authenticated-orcid":false,"given":"Adele","family":"Cicio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1937-0637","authenticated-orcid":false,"given":"Rosa","family":"Serio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"2366_CR1","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/HUMUPD\/DMQ016","volume":"16","author":"HN Aguilar","year":"2010","unstructured":"Aguilar HN, Mitchell BF (2010) Physiological pathways and molecular mechanisms regulating uterine contractility. Hum Reprod Update 16:725\u2013744. https:\/\/doi.org\/10.1093\/HUMUPD\/DMQ016","journal-title":"Hum Reprod Update"},{"key":"2366_CR2","doi-asserted-by":"publisher","first-page":"29626","DOI":"10.1074\/JBC.273.45.29626","volume":"273","author":"LI Benowitz","year":"1998","unstructured":"Benowitz LI, Jing Y, Tabibiazar R et al (1998) Axon outgrowth is regulated by an intracellular purine-sensitive mechanism in retinal ganglion cells. J Biol Chem 273:29626\u201329634. https:\/\/doi.org\/10.1074\/JBC.273.45.29626","journal-title":"J Biol Chem"},{"key":"2366_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/S11302-013-9399-7","volume":"10","author":"G Burnstock","year":"2014","unstructured":"Burnstock G (2014) Purinergic signalling in the reproductive system in health and disease. Purinergic Signal 10:157. https:\/\/doi.org\/10.1007\/S11302-013-9399-7","journal-title":"Purinergic Signal"},{"key":"2366_CR4","doi-asserted-by":"publisher","first-page":"11049","DOI":"10.1073\/PNAS.94.20.11049","volume":"94","author":"M Chaud","year":"1997","unstructured":"Chaud M, Franchi AM, Rettori V et al (1997) Nitric oxide in the contractile action of bradykinin, oxytocin, and prostaglandin F2 \u03b1 in the estrogenized rat uterus. Proc Natl Acad Sci U S A 94:11049\u201311054. https:\/\/doi.org\/10.1073\/PNAS.94.20.11049","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2366_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/J.CECA.2006.03.008","volume":"40","author":"F Dabertrand","year":"2006","unstructured":"Dabertrand F, Morel JL, Sorrentino V et al (2006) Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells. Cell Calcium 40:11\u201321. https:\/\/doi.org\/10.1016\/J.CECA.2006.03.008","journal-title":"Cell Calcium"},{"key":"2366_CR6","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/JNC.12324","volume":"126","author":"T Dal-Cim","year":"2013","unstructured":"Dal-Cim T, Ludka FK, Martins WC et al (2013) Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions. J Neurochem 126:437\u2013450. https:\/\/doi.org\/10.1111\/JNC.12324","journal-title":"J Neurochem"},{"key":"2366_CR7","doi-asserted-by":"publisher","unstructured":"Di Liberto V, Mud\u00f2 G, Garozzo R, et al (2016) The guanine-based purinergic system: the tale of an orphan neuromodulation. Front Pharmacol 7:. https:\/\/doi.org\/10.3389\/FPHAR.2016.00158","DOI":"10.3389\/FPHAR.2016.00158"},{"key":"2366_CR8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1113\/JPHYSIOL.1989.SP017474","volume":"408","author":"T Fujiwara","year":"1989","unstructured":"Fujiwara T, Itoh T, Kubota Y, Kuriyama H (1989) Effects of guanosine nucleotides on skinned smooth muscle tissue of the rabbit mesenteric artery. J Physiol 408:535\u2013547. https:\/\/doi.org\/10.1113\/JPHYSIOL.1989.SP017474","journal-title":"J Physiol"},{"key":"2366_CR9","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1111\/J.1440-1681.1998.TB02257.X","volume":"25","author":"TA Gillman","year":"1998","unstructured":"Gillman TA, Pennefather JN (1998) Evidence for the presence of both P1 and P2 purinoceptors in the rat myometrium. Clin Exp Pharmacol Physiol 25:592\u2013599. https:\/\/doi.org\/10.1111\/J.1440-1681.1998.TB02257.X","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2366_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1124\/jpet.119.264143","volume":"372","author":"MC Michel","year":"2020","unstructured":"Michel MC, Murphy TJ, Motulsky HJ (2020) New author guidelines for displaying data and reporting data analysis and statistical methods in experimental biology. J Pharmacol Exp Ther 372:136\u2013147. https:\/\/doi.org\/10.1124\/jpet.119.264143","journal-title":"J Pharmacol Exp Ther"},{"key":"2366_CR11","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/S00210-014-1037-6","volume":"387","author":"HJ Motulsky","year":"2014","unstructured":"Motulsky HJ (2014) Common misconceptions about data analysis and statistics. Naunyn Schmiedebergs Arch Pharmacol 387:1017\u20131023. https:\/\/doi.org\/10.1007\/S00210-014-1037-6","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2366_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/J.NEUINT.2007.07.017","volume":"52","author":"SPB Oleskovicz","year":"2008","unstructured":"Oleskovicz SPB, Martins WC, Leal RB, Tasca CI (2008) Mechanism of guanosine-induced neuroprotection in rat hippocampal slices submitted to oxygen-glucose deprivation. Neurochem Int 52:411\u2013418. https:\/\/doi.org\/10.1016\/J.NEUINT.2007.07.017","journal-title":"Neurochem Int"},{"key":"2366_CR13","doi-asserted-by":"publisher","unstructured":"Rathbone M, Pilutti L, Caciagli F, Jiang S (2008) Neurotrophic effects of extracellular guanosine. 27:666\u2013672. https:\/\/doi.org\/10.1080\/15257770802143913","DOI":"10.1080\/15257770802143913"},{"key":"2366_CR14","doi-asserted-by":"publisher","unstructured":"Tasca CI, Lanznaster D, Oliveira KA, et al (2018) Neuromodulatory effects of guanine-based purines in health and disease. Front Cell Neurosci 12:. https:\/\/doi.org\/10.3389\/FNCEL.2018.00376","DOI":"10.3389\/FNCEL.2018.00376"},{"key":"2366_CR15","doi-asserted-by":"publisher","first-page":"5417","DOI":"10.1016\/J.BMC.2003.09.043","volume":"11","author":"U Traversa","year":"2003","unstructured":"Traversa U, Bombi G, Camaioni E et al (2003) Rat brain guanosine binding site. Biological studies and pseudo-receptor construction. Bioorg Med Chem 11:5417\u20135425. https:\/\/doi.org\/10.1016\/J.BMC.2003.09.043","journal-title":"Bioorg Med Chem"},{"key":"2366_CR16","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1016\/S0024-3205(00)80004-1","volume":"66","author":"MM Trujillo","year":"2000","unstructured":"Trujillo MM, Ausina P, Savineau JP et al (2000) Cellular mechanisms involved in iso-osmotic high K+ solutions-induced contraction of the estrogen-primed rat myometrium. Life Sci 66:2441\u20132453. https:\/\/doi.org\/10.1016\/S0024-3205(00)80004-1","journal-title":"Life Sci"},{"key":"2366_CR17","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/CMDC.201100100","volume":"6","author":"R Volpini","year":"2011","unstructured":"Volpini R, Marucci G, Buccioni M et al (2011) Evidence for the existence of a specific g protein-coupled receptor activated by guanosine. ChemMedChem 6:1074\u20131080. https:\/\/doi.org\/10.1002\/CMDC.201100100","journal-title":"ChemMedChem"},{"key":"2366_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/J.SEMCDB.2007.05.005","volume":"18","author":"S Wray","year":"2007","unstructured":"Wray S, Shmygol A (2007) Role of the calcium store in uterine contractility. Semin Cell Dev Biol 18:315\u2013320. https:\/\/doi.org\/10.1016\/J.SEMCDB.2007.05.005","journal-title":"Semin Cell Dev Biol"},{"key":"2366_CR19","doi-asserted-by":"publisher","unstructured":"Zizzo MG, Auteri M, Amato A, et al (2017) Angiotensin II type II receptors and colonic dysmotility in 2,4-dinitrofluorobenzenesulfonic acid-induced colitis in rats. Neurogastroenterol Motil 29:. https:\/\/doi.org\/10.1111\/nmo.13019","DOI":"10.1111\/nmo.13019"},{"key":"2366_CR20","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/S11302-013-9378-Z","volume":"9","author":"MG Zizzo","year":"2013","unstructured":"Zizzo MG, Mul\u00e8 F, Amato A et al (2013) Guanosine negatively modulates the gastric motor function in mouse. Purinergic Signal 9:655\u2013661. https:\/\/doi.org\/10.1007\/S11302-013-9378-Z","journal-title":"Purinergic Signal"},{"key":"2366_CR21","doi-asserted-by":"publisher","unstructured":"Zizzo MG, Mul\u00e8 F, Mastropaolo M, et al (2011) Can guanine-based purines be considered modulators of intestinal motility in rodents? Eur J Pharmacol 650:. https:\/\/doi.org\/10.1016\/j.ejphar.2010.09.062","DOI":"10.1016\/j.ejphar.2010.09.062"},{"key":"2366_CR22","doi-asserted-by":"publisher","unstructured":"Zizzo MG, Mul\u00e8 F, Mastropaolo M, Serio R (2010) D1 receptors play a major role in the dopamine modulation of mouse ileum contractility. Pharmacol Res 61:. https:\/\/doi.org\/10.1016\/j.phrs.2010.01.015","DOI":"10.1016\/j.phrs.2010.01.015"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02366-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-022-02366-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-022-02366-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T10:06:29Z","timestamp":1680775589000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-022-02366-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["2366"],"URL":"https:\/\/doi.org\/10.1007\/s00210-022-02366-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"type":"print","value":"0028-1298"},{"type":"electronic","value":"1432-1912"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"6 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal care was approved by the Animal Care and Use Ethics Committee of the University of Palermo and performed in accordance with national.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors authorize the submission and publication of this article <i>in<\/i><i>Naunyn\u2013Schmiedeberg\u2019s Archives of Pharmacology.<\/i>","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}